Digital Commons Network^™

Overlooked Ionic Contribution Of A Chiral Dopant In Cholesteric Liquid Crystals, Hassanein Shaban, Po-Chang Wu, Yi-Fei Jia, Wei Lee

Basic Science Engineering

This study focuses on the ionic contribution by a chiral dopant added into a nematic host for preparing cholesteric liquid crystals (CLCs). Chiral structures were designated by individually incorporating two enantiomers, R5011 and S5011, into the nematic E44 to construct right- and left-handed CLCs, respectively. Characterized by the space-charge polarization, the dielectric spectra of the CLCs were investigated in the low-frequency regime, where f ≤ 1 kHz. The role of the individual chiral dopant, R5011 or S5011, at concentrations of 0–4.0 wt.% in altering the ionic properties of the CLC material was analyzed by deducing the electrical conductivity, ion density, …

Social Isolation And Loneliness Prevention Among Rural Older Adults Aging-In-Place: A Needs Assessment, Jodi L. Southerland, Shimin Zheng, Kayla Dodson, Erin Mauck, Juanita-Dawne R. Bacsu, Monique J. Brown Ph.D., Mph, Jeremy Holloway, Steffi M. Kim, Ayse Malatyali, Matthew Lee Smith

Faculty Publications

Introduction: The adverse effects of social isolation and loneliness (SI/L) have been documented among older adults in rural communities and contribute to poor health outcomes, premature disability and mortality, and increased burden on the healthcare system. The identification of factors contributing to SI/L among older adults can build the foundation for rural policymakers and leaders to allocate resources and develop tailored strategies more efficiently. The purpose of this article is to describe findings from a needs assessment designed to understand local factors that contribute to SI/L among rural older adults in a county in Northeast Tennessee. Findings from the needs …

Topography Of The 410 And 660 Km Discontinuities Beneath The Tibetan Plateau And Adjacent Areas, Zexin Miao, Stephen S. Gao, Muchen Sun, Kelly H. Liu

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

To investigate the three-dimensional spatial distribution of subducted oceanic slab segments and their consequential effect on the thermal and hydrous composition of the mantle transition zone (MTZ) beneath the entire Tibetan Plateau, we conducted a comprehensive analysis of approximately 655,000 P-to-s receiver functions (RFs), obtained from 735 broadband seismic stations. These RFs were utilized to delineate the 410 km (d410) and 660 km (d660) seismic discontinuities, which represent the upper and lower boundaries of the MTZ, respectively. The RFs were grouped within circular bins with a radius of 1 degree and stacked to image the discontinuities. The mean apparent depths …

United States Centers For Disease Control And Prevention Scientific Integrity Policy

Copyright, Fair Use, Scholarly Communication, etc.

US CDC SIP

Ethical Leadership Case Collection: The Offer: Bribery Over Recruitment, May Phuu Thwel, Natalie Castelan Marquez, Zena Musleh

GHEA21 Open Educational Resources

The Ethical Leadership Case Collection is the product of the Network Collaborative Course entitled Ethical Leadership. The course explores approaches to ethical leadership not just in the abstract, but as a discipline that is focused on action. The course is grounded in students’ perspectives on the ethical and leadership challenges they face in their own lives and communities. As an approach to thinking through ethical leadership, the course is structured around the concerns explored in Dr. Mary Gentile's Giving Voice to Values framework. Students developed case studies of their own.

Path Following Control And Simulation Analysis Of Multi-Articulated Vehicles, Yu Zhao, Caijin Yang, Tanming Wang, Jing Xu, Shuai Zhou

Journal of System Simulation

Abstract: The structure of multi-articulated vehicle body limits the flexibility of the vehicle and causes the deviation of the rear vehicle. Taking the ideal articulation angle as the control target, a feedforward plus feedback path following control method is proposed, which realizes the precise path following of rear vehicle bodies by minimizing the deviation between the ideal articulation angle and the actual articulation angle. According to the geometric position relationship between the vehicle and the desired path, the traditional calculation method of the ideal articulation angle is improved from two perspectives of application range and error accumulation. Based on the …

Improved Foggy Pedestrian And Vehicle Detection Algorithm Based On Yolov5, Tong Su, Ying Wang, Qiyang Deng, Zhaobin Li

Journal of System Simulation

Abstract: Due to the poor environment perception of car in bad weather, the detection ability on dynamic targets is significantly reduced, and thus the problems such as low accuracy and poor robustness of the deep learning-based target detection network will occur when detecting pedestrians and vehicles in foggy days. A YOLOv5-SGE foggy detection network is proposed on the basis of the combination of image dehazing DehazeNet and the improved YOLOv5. The adaptive calculation of anchor frame is realized by canceling the initial anchor frame of YOLOv5, and the anchor frame suitable for the current dataset is generated. A three-dimensional weighted …

Peer-To-Peer Energy-Carbon Management Method Of Multiple Integrated Energy Systems Considering Multi-Agent Interaction Strategy, Yudong Wang, Junjie Hu

Journal of System Simulation

Abstract: To explore a new energy management model of P2P transaction of electricity, heat and carbon among IES with the participation of ESP, a P2P energy-carbon management method of IES considering multi-agent interaction strategy is proposed. A two-layer energy management framework with the multiagent participation of involving ESP and IES is established. A two-layer electricity-heat-carbon energy management model is constructed in which the upper model is constructed based on reinforcement learning framework to optimize the energy management strategy between ESP and IES cooperative alliance and the lower model is based on Nash negotiation game theory to optimize the cooperative operation …

A Taking By Any Other Name: Why Exclusionary Zoning Should Be Classified As A Per Se Taking, Matthew J. Ruppel

Seattle University Law Review Online

The housing affordability crisis in U.S. cities, particularly on the West Coast, has been well publicized in recent years, and the search for solutions has drawn together allies from across the ideological spectrum. While various cities and states have rolled out many types of reforms, there remains a widespread regulatory failure preventing the adaptation of cities to modern demands. A primary culprit is exclusionary zoning: plot-by-plot designation of which types of structures can be built on a piece of property— particularly which types of structures are absolutely prohibited from being built—and the broad definitional standards to which those structures must …

Knowledge Discovery Of Patients Reviews On Breast Cancer Drugs: Segmentation Of Side Effects Using Machine Learning Techniques, Mehrbakhsh Nilashi, Hossein Ahmadi, Rabab Ali Abumalloh, Mesfer Alrizq, Abdullah Alghamdi, Sultan Alyami

School of Nursing and Midwifery

Breast cancer stands as the most frequently diagnosed life-threatening cancer among women worldwide. Understanding patients' drug experiences is essential to improving treatment strategies and outcomes. In this research, we conduct knowledge discovery on breast cancer drugs using patients’ reviews. A new machine learning approach is developed by employing clustering, text mining and regression techniques. We first use Latent Dirichlet Allocation (LDA) technique to discover the main aspects of patients' experiences from the patients’ reviews on breast cancer drugs. We also use Expectation-Maximization (EM) algorithm to segment the data based on patients’ overall satisfaction. We then use the Forward Entry Regression …

Development And Validation Of A Machine Learning Model To Predict Myocardial Blood Flow And Clinical Outcomes From Patients’ Electrocardiogram, Fares Alahdab, Maliazurina Binti Saad, Ahmed Ibrahim Ahmed, Qasem Al Tashi, Muhammad Aminu, Yushui Han, Jonathan B Moody, Venkatesh L Murthy, Jia Wu, Mouaz H Al-Mallah

Faculty, Staff and Student Publications

We develop a machine learning (ML) model using electrocardiography (ECG) to predict myocardial blood flow reserve (MFR) and assess its prognostic value for major adverse cardiovascular events (MACEs). Using 3,639 ECG-positron emission tomography (PET) and 17,649 ECG-single-photon emission computed tomography (SPECT) data pairs, the ML model is trained with a swarm intelligence approach and support vector regression (SVR). The model achieves a receiver-operator curve (ROC) area under the curve (AUC) of 0.83, with a sensitivity and specificity of 0.75. An ECG-MFR value below 2 is significantly associated with MACE, with hazard ratios (HRs) of 3.85 and 3.70 in the discovery …

Preparation Of Wound Dressings Using Levan From Lactobacillus Gasseri And Polyvinyl Alcohol Polymer, Jehan Abdul Sattar Salman, Shaimaa Ms Zainulabdeen

Muthanna Medical Journal

Levan had been extracted, purified, and characterized from Lactobacillus gasseri. Levan characterization had been carried out using "thin-layer chromatography (TLC)", 1HNuclear-MagneticsResonances (HNMR), and Fouriere-transforms infrared spectroscopies (FTIR). Characterization demonstrated that pure levan is a homopolysaccharide with just fructose and atypical for carbohydrate bond area of 868 cm-1. The maximum water solubility index (WSI) percentage was 90% at a conc. of 100 mg/5 ml, while the highest water holding capacity value had been 252 at a conc. of 50 mg/5 ml. The wound dressings were prepared using purified levan from L.gasseri and its blend with polyvinyl alcohol (PVA) polymer, and the …

Design, Fabrication And Performance Evaluation Of Parabolic And Enhanced Solar Box Cookers In Isimani, Tanzania, Margaret E Samiji, Nuru R Mlyuka

Tanzania Journal of Science

Clean cooking energy is a global priority, especially in developing countries where firewood and charcoal remain the primary cooking fuels. Solar cooking is an attractive alternative in these countries since it is eco-friendly and utilises freely available solar radiation. Utilisation of solar cookers however is still very low mainly due to the perceived complexity and lack of confidence in the available solar cooker models. In this work, the enhanced box and parabolic solar cookers were designed, fabricated and tested taking into consideration standard solar cookers and local cooking requirements. The enhanced box solar cooker was designed with booster mirrors making …

Essays On Information Technology In Healthcare, Gleb Zavadskiy

USF Tampa Graduate Theses and Dissertations

Information technologies (IT) and information systems (IS) have profound significance across various sectors of society, including healthcare, business, education, government, and beyond. First, IT facilitates instant communication globally through email, messaging apps, video conferencing, and social media, revolutionizing how individuals and organizations interact, collaborate, and share information (Hacker et al. 2020; Tang and Hew 2020).

Secondly, the Internet and digital libraries provide worldwide access to vast amounts of information, what makes knowledge and education available to everyone, empowering individuals to learn and stay informed on diverse topics (Haleem et al. 2022). Another aspect of IT systems in various industries is …

Yap1 Status Defines Two Intrinsic Subtypes Of Lcnec With Distinct Molecular Features And Therapeutic Vulnerabilities, C Allison Stewart, Lixia Diao, Yuanxin Xi, Runsheng Wang, Kavya Ramkumar, Alejandra G Serrano, Azusa Tanimoto, B Leticia Rodriguez, Benjamin B Morris, Li Shen, Bingnan Zhang, Yan Yang, Samera H Hamad, Robert J Cardnell, Alberto Duarte, Moushumi Sahu, Veronica Y Novegil, Bernard E Weissman, Michael Frumovitz, Neda Kalhor, Luisa Solis Soto, Pedro Da Rocha, Natalie Vokes, Don L Gibbons, Jing Wang, John V Heymach, Bonnie Glisson, Lauren Averett Byers, Carl M Gay

Faculty, Staff and Student Publications

Purpose: Large cell neuroendocrine carcinoma (LCNEC) is a high-grade neuroendocrine malignancy that, like small cell lung cancer (SCLC), is associated with the absence of druggable oncogenic drivers and dismal prognosis. In contrast to SCLC, however, there is little evidence to guide optimal treatment strategies, which are often adapted from SCLC and non-small cell lung cancer approaches.

Experimental design: To better define the biology of LCNEC, we analyzed cell line and patient genomic data and performed IHC and single-cell RNA sequencing of core needle biopsies from patients with LCNEC and preclinical models.

Results: In this study, we demonstrate that the presence …

Cdk12 Loss Drives Prostate Cancer Progression, Transcription-Replication Conflicts, And Synthetic Lethality With Paralog Cdk13, Jean Ching-Yi Tien, Jie Luo, Yu Chang, Yuping Zhang, Yunhui Cheng, Xiaoju Wang, Jianzhang Yang, Rahul Mannan, Somnath Mahapatra, Palak Shah, Xiao-Ming Wang, Abigail J Todd, Sanjana Eyunni, Caleb Cheng, Ryan J Rebernick, Lanbo Xiao, Yi Bao, James Neiswender, Rachel Brough, Stephen J Pettitt, Xuhong Cao, Stephanie J Miner, Licheng Zhou, Yi-Mi Wu, Estefania Labanca, Yuzhuo Wang, Abhijit Parolia, Marcin Cieslik, Dan R Robinson, Zhen Wang, Felix Y Feng, Jonathan Chou, Christopher J Lord, Ke Ding, Arul M Chinnaiyan

Faculty, Staff and Student Publications

Biallelic loss of cyclin-dependent kinase 12 (CDK12) defines a metastatic castration-resistant prostate cancer (mCRPC) subtype. It remains unclear, however, whether CDK12 loss drives prostate cancer (PCa) development or uncovers pharmacologic vulnerabilities. Here, we show Cdk12 ablation in murine prostate epithelium is sufficient to induce preneoplastic lesions with lymphocytic infiltration. In allograft-based CRISPR screening, Cdk12 loss associates positively with Trp53 inactivation but negatively with Pten inactivation. Moreover, concurrent Cdk12/Trp53 ablation promotes proliferation of prostate-derived organoids, while Cdk12 knockout in Pten-null mice abrogates prostate tumor growth. In syngeneic systems, Cdk12/Trp53-null allografts exhibit luminal morphology and immune checkpoint blockade sensitivity. Mechanistically, Cdk12 inactivation …

Microwave-Assisted Hydrothermal Synthesis Of Photocatalytic Truncated-Bipyramidal Tio2/Ti3cn Heterostructures Derived From Ti3cn Mxene, Muhammad Abiyyu Kenichi Purbayanto, Madhurya Chandel, Dominika Bury, Anna Wójcik, Dorota Moszczyńska, Anika Tabassum, Vadym Mochalin, Michael Naguib, Agnieszka Maria Jastrzębska

Chemistry Faculty Research & Creative Works

TiO₂/MXene heterostructure has garnered significant interest as a photocatalyst due to its large surface area and efficient charge carrier separation at the interface. However, current synthesis methods produce TiO₂ without clear crystal faceting and often require complicated postprocessing step, limiting its practical applications. We demonstrate a facile and controlled microwave-assisted hydrothermal synthesis for transforming multilayered Ti₃CN MXene to a truncated-bipyramidal TiO₂/Ti₃CN heterostructure. The resulting TiO₂ nanocrystals at the Ti₃CN surface exhibited crystalline anatase truncated bipyramids, exposing {001} and {101} facets. We further tailored an indirect optical band gap …

Influence Of Mindfulness On Online Information Searching Strategies Of The University Of Ibadan Undergraduate Students, Abiola Moses Akinwale Mr

Library Philosophy and Practice (e-journal)

The objective of the study was to determine the impact of mindfulness on online information search strategies of undergraduate students at the University of Ibadan. The study assessed the level of online information search strategies, and mindfulness dimension, aiming at identifying the relationship between the independent variable (mindfulness dimension) on online information search strategies. The study was conducted on undergraduate students of the University of Ibadan.

The research adopted a correlational research survey design, with a total population of 11,812 students across seven faculties that were purposively determined, and a sample of 387 using Yamane (1967) sampling formula. The data …

Poshuouinge — City At The Center, All Roads Lead To Poshu, Alice Ruth Gomez

Architecture and Planning ETDs

Poshuouinge was situated in the center of not only the space of the Lower Río Chama Valley, but in the center of the time the Valley was inhabited by Tewa ancestors between the 12th and 16th centuries. Its architecture ends the Coalition Period (AD 1200-1325) and begins the the Classic (AD 1325-1600), a time of population growth and prosperity, trade expansion and diversity, all due to major agricultural innovations unique to the Valley. The new style architecture lent itself to fewer restrictions for neighbors and visitors, and was replicated in some fashion in the Valley’s other nine largest communities. Poshuouinge’s …

First-In-Human Clinical Outcomes With Ng-350a, An Anti-Cd40 Expressing Tumor-Selective Vector Designed To Remodel Immunosuppressive Tumor Microenvironments, Aung Naing, Danny Khalil, Oliver Rosen, D Ross Camidge, Tom Lillie, Rui-Ru Ji, Andrea Stacey, Matthew Thomas, Lee Rosen

Faculty, Staff and Student Publications

Background: Tumor-selective oncolytic viral vectors are promising anticancer therapeutics; however, challenges with dosing and potency in advanced/metastatic cancers have limited efficacy and usage. NG-350A is a next-generation blood-stable adenoviral vector engineered to express an agonist anti-cluster of differentiation (CD)40 antibody without affecting tumor-selectivity and oncolytic potency.

Methods: Intravenous and intratumoral (IT) administration of NG-350A was assessed in a phase Ia/Ib study in patients with metastatic/advanced epithelial tumors (NCT03852511). Dose-escalation was performed separately for intravenous (four dose levels available, each with infusions on Days 1, 3 and 5 of a 57-day treatment period) and IT (single injection on D1 …

Magnetoelectrics For Implantable Bioelectronics: Progress To Date, Fatima Alrashdan, Kaiyuan Yang, Jacob T Robinson

Faculty, Staff and Students Publications

The coupling of magnetic and electric properties manifested in magnetoelectric (ME) materials has unlocked numerous possibilities for advancing technologies like energy harvesting, memory devices, and medical technologies. Due to this unique coupling, the magnetic properties of these materials can be tuned by an electric field; conversely, their electric polarization can be manipulated through a magnetic field. Over the past seven years, our lab work has focused on leveraging these materials to engineer implantable bioelectronics for various neuromodulation applications. One of the main challenges for bioelectronics is to design miniaturized solutions that can be delivered with minimally invasive procedures and yet …

Sall4 And Gata4 Induce Cardiac Fibroblast Transition Towards A Partially Multipotent State With Cardiogenic Potential, Hong Gao, Saliha Pathan, Beverly R E A Dixon, Aarthi Pugazenthi, Megumi Mathison, Tamer M A Mohamed, Todd K Rosengart, Jianchang Yang

Faculty, Staff and Students Publications

Cardiac cellular fate transition holds remarkable promise for the treatment of ischemic heart disease. We report that overexpressing two transcription factors, Sall4 and Gata4, which play distinct and overlapping roles in both pluripotent stem cell reprogramming and embryonic heart development, induces a fraction of stem-like cells in rodent cardiac fibroblasts that exhibit unlimited ex vivo expandability with clonogenicity. Transcriptomic and phenotypic analyses reveal that around 32 ± 6.4% of the expanding cells express Nkx2.5, while 13 ± 3.6% express Oct4. Activated signaling pathways like PI3K/Akt, Hippo, Wnt, and multiple epigenetic modification enzymes are also detected. Under suitable conditions, these cells …

Electric Potential Energy Optimized 3d Radial Sampling Trajectories For Mri, Christopher Huynh, Datta Singh Goolaub, Christopher K Macgowan

Faculty, Staff and Students Publications

A novel method for creating “golden” 3D center-out radial MRI sampling trajectories was developed and analyzed. This method, called ELECTRO (ELECTRic potential energy Optimized), uses repulsive forces to minimize electric potential energy. An objective function , the electric potential energies of all subsets of consecutive readouts in a 3D radial trajectory, and its reduced form were minimized using a multi-stage optimization strategy. A metric called normalized mean nearest neighbor angular distance (NMNA) was proposed for describing distributions of points on a sphere. ELECTRO and other relevant golden trajectories were compared in silico using NMNA and point spread function analysis. Consecutive …

Stereo Vision Relative Navigation Of Airborne Vehicles, Scott L. Nykl, Brian Woolley, John Pecarina

AFIT Patents

An automated aerial formation (AAF) system includes an imaging device mounted on an imaging first aircraft that receives reflected energy from an imaged second aircraft. A controller is communicatively coupled to the imaging device and a flight control system of one of the first and the second aircraft. The controller generates a three-dimensional (3D) point cloud based on the reflected energy and identifies a target 3D model in the 3D point cloud. The controller rotates and scales one of a pre-defined 3D model and the target 3D model to find a 3D point registration between the target 3D model and …

Invertebrate Pests, Plant Pathogens, And Beneficial Organisms In Extensive Natural Grassland, J G. Watts, L W. Burgess, E W. Huddleston

IGC Proceedings (1977-2023)

After many decades of research on their control, insects and weeds still arc a major factor in semi-arid grassland ranching. Much has been learned concerning their biology, habits and chemical control but penetrating study of the microbial world surrounding them is quite recent. Plant pathogens are credited with little damage to semi­arid grasslands. Potentially, their most important role may be one of toxigensis among grazing animals after unusual weather that promotes exceptional increase of any one or a combination of several indigenous toxigenic fungi on senescing grasses. Objective cost-benefit consideration of pest and disease control was limited in past decades …

The Daily Gamecock: October 2024, University Of South Carolina, Office Of Student Media

October

No abstract provided.

2024 October 14 - University Council Agenda And Minutes, University Council, East Tennessee State University

University Council Agendas and Minutes

No abstract provided.

Indigenous Science Network Bulletin - November 2024

Indigenous Science Network

Board Chair, Liz McKinley has written an inspiring editorial that reflects on her journey as a Maori science educator working across all levels in a career spanning over 40 years. Liz also touches on one of the long running controversies that seems unavoidable in this space, that of the value and credibility of allowing non-western cultural knowledge into science curricula and pedagogy. The program of the second biennial Turtle Island Indigenous Science Conference, held at the University of Regina in Canada is available. This issue also contains three items written specifically for us. The first is a summary of the …

A Deep Autoencoder For Electric Double Layer Capacitance Prediction In Electrochemical Sensors, Mason Mcgarrity, Feng Zhao

Electrical and Computer Engineering Faculty Research & Creative Works

This study explores the application of a deep autoencoder neural network to accurately predict the electric double layer capacitance from real-world parameters in binary, asymmetric electrolytes under low concentration conditions. By utilizing a modest simulation-based dataset of just 250 samples, the deep autoencoder neural network model developed in this study effectively predicted the capacitance by learning the critical features and relationships of the electric double layer model and encoding this learned representation into a low-dimensional latent space. From the latent variables, the decoder block of the neural network learned to effectively recreate the high-dimensional input. To enhance the model's robustness, …

Cross-Track Seabed Imaging And Buried Object Detection With A Multibeam Sonar, Charles W. Holland, Samuel Pinson, Daniel L. Orange, Cody R. Henderson

Electrical and Computer Engineering Faculty Publications and Presentations

What lies underneath the ocean floor is of interest to a wide variety of disciplines. The focus here is imaging the upper tens of meters of material beneath the seafloor. The sub-bottom profiler is a valuable tool to that end, producing a 2-D image in depth below the seafloor and along the track of the ship. Geoscientists and engineers are frequently interested in not only the subseabed beneath the ship but also either side or cross-track of the ship. We show an approach to cross-track imaging using a low-frequency multibeam sub-bottom profiler. The main result is the detection of a …