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In A Moment: The Texture Of Transformative Experience, Amanda F. Mina Oct 2024

In A Moment: The Texture Of Transformative Experience, Amanda F. Mina

Journal of Conscious Evolution

This paper analyzes the personal narrative of a shocking event. The context of the event is established and the event itself is reflected upon as an experience of time dilation. This moment is examined through Welch’s (2010) elements of deepening time: repetition, attention, and intention, aligning the phenomenon with elements of Gebser’s (1985) integral structure of consciousness to place the experience within the movement toward the integral. Connections identified through the experience offer support for the idea that transcendent experiences of time are possible outside of the event itself and may lend themselves to personal transformation and point toward a …

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Executive Committee - Agenda, 10/15/2024, Academic Senate Oct 2024

Executive Committee - Agenda, 10/15/2024, Academic Senate

Academic Senate Agendas

No abstract provided.

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Exploring The Impact Of Lighting Sources On Walking Behavior In Obstructed Walkways Among Older Adults, Yue Luo, Yuhao Chen, Gaojian Huang, Boyi Hu Oct 2024

Exploring The Impact Of Lighting Sources On Walking Behavior In Obstructed Walkways Among Older Adults, Yue Luo, Yuhao Chen, Gaojian Huang, Boyi Hu

Faculty Research, Scholarly, and Creative Activity

The pandemic has reinforced older adults' reliance on their homes and the concept of “aging in place”. Changes like reduced physical strength and cognitive deficit, however, have heightened the challenge of simple tasks like obstacle crossing among older adults, let alone when older adults cannot perceive the surroundings well during the nighttime. The study is, therefore, to evaluate the impact of lighting on older adults' obstacle-crossing behavior during the nighttime. Twenty-seven older adults (81 ± 6 yrs., 171 ± 12 cm, 75 ± 20 kg, 14 females) were recruited. Participants were asked to cross over the obstacle in a dark …

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A (Sub)Field Guide To Quality Control In Hippocampal Subfield Segmentation On High-Resolution T2-Weighted Mri, Kelsey L. Canada, Negar Mazloum-Farzaghi, Gustaf Rådman, Jenna N. Adams, Arnold Bakker, Hannah Baumeister, David Berron, Martina Bocchetta, Valerie A. Carr, Marshall A. Dalton, Robin De Flores, Attila Keresztes, Renaud La Joie, Susanne G. Mueller, Naftali Raz, Tales Santini, Thomas Shaw, Craig E.L. Stark, Tammy T. Tran Oct 2024

A (Sub)Field Guide To Quality Control In Hippocampal Subfield Segmentation On High-Resolution T2-Weighted Mri, Kelsey L. Canada, Negar Mazloum-Farzaghi, Gustaf Rådman, Jenna N. Adams, Arnold Bakker, Hannah Baumeister, David Berron, Martina Bocchetta, Valerie A. Carr, Marshall A. Dalton, Robin De Flores, Attila Keresztes, Renaud La Joie, Susanne G. Mueller, Naftali Raz, Tales Santini, Thomas Shaw, Craig E.L. Stark, Tammy T. Tran

Faculty Research, Scholarly, and Creative Activity

Inquiries into properties of brain structure and function have progressed due to developments in magnetic resonance imaging (MRI). To sustain progress in investigating and quantifying neuroanatomical details in vivo, the reliability and validity of brain measurements are paramount. Quality control (QC) is a set of procedures for mitigating errors and ensuring the validity and reliability of brain measurements. Despite its importance, there is little guidance on best QC practices and reporting procedures. The study of hippocampal subfields in vivo is a critical case for QC because of their small size, inter-dependent boundary definitions, and common artifacts in the MRI data …

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Surface-Enhanced Raman Spectroscopy For Point-Of-Care Bioanalysis: From Lab To Field, Vineeth Puravankara, Aravind Manjeri, Young Ho Kim, Yasutaka Kitahama Oct 2024

Surface-Enhanced Raman Spectroscopy For Point-Of-Care Bioanalysis: From Lab To Field, Vineeth Puravankara, Aravind Manjeri, Young Ho Kim, Yasutaka Kitahama

Open Access archive

In the ever-evolving landscape of biomedical diagnostics, the early diagnosis of a disease is important for not only a patient but also the public health of a country. In this regard, the detection of pathogens as well as the analysis of biomarkers from body fluids, for preventive healthcare at a very low concentration have been the subject of intense research lately. Despite the availability of numerous analytical tools, detecting trace concentrations of analyte with high specificity remains a formidable challenge. Driven by the advances in micro-nanofabrication tools, photonics, and nanotechnologies, a variety of optical techniques that utilize nanostructures or nanoparticles …

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Adaptive Tracking Control For Omnidirectional Vehicle Based On Characteristic Modeling, Lei Cheng, Haoyou Wang, Xinjie Chen Oct 2024

Adaptive Tracking Control For Omnidirectional Vehicle Based On Characteristic Modeling, Lei Cheng, Haoyou Wang, Xinjie Chen

Journal of System Simulation

Abstract: Aiming at the stable and high-precision tracking control of omnidirectional mobile vehicles affected by their own characteristics and external disturbances, an adaptive tracking control approach for omnidirectional vehicles based on characteristic modeling is designed. The characteristic model is established by integrating the model properties into the characteristic parameters, and the characteristic parameters are estimated online by using the projected gradient method. A full coefficient adaptive control law based on the characteristic model is designed, and the stability of the proposed control method is analyzed by using Lyapunov theory. The effectiveness and rationality of the proposed adaptive control scheme are …

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Comparison Of Outlier Detection Approaches For Compressive Strength Of Cement-Based Mortars, Nara Cangussu, Paula Milheiro-Oliveira, Ana Mafalda Matos, Farhad Aslani, Lino Maia Oct 2024

Comparison Of Outlier Detection Approaches For Compressive Strength Of Cement-Based Mortars, Nara Cangussu, Paula Milheiro-Oliveira, Ana Mafalda Matos, Farhad Aslani, Lino Maia

Research outputs 2022 to 2026

EN 196-1 states that the compressive strength result of testing of standard mortar specimens corresponds to the average of the six individual measurements. If one of the six individual measurements varies more than ±10 % from the average, it must be excluded, and a new average is calculated with the five remaining values. This methodology might be interesting for quality control or characterization of cement; however, it may not be the best approach for research or scientific purposes. Applying EN 196-1 to non-standard cement-based mortars with multiple and even unconventional supplementary cementitious materials may induce even more variation in the …

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Wormhole Attack Mitigation In Wireless Network Using Propagation Delay, Harry May, Travis Atkison Oct 2024

Wormhole Attack Mitigation In Wireless Network Using Propagation Delay, Harry May, Travis Atkison

Journal of Cybersecurity Education, Research and Practice

This paper presents a novel approach for mitigating wormhole attacks on wireless networks using propagation delay timing. The wormhole attack is a persistent security threat that threatens the integrity of network communications, potentially leading to data theft or other malicious activities. While various methods exist for combating wormhole attacks, our approach offers advantages that set it apart. Our approach involves a combination of proactive and reactive measures, harnessing box plot analysis and weighting factor techniques to identify and isolate outlier node links effectively. Unlike traditional methods, our solution not only detects outlier links but also defines dynamic weighting factors, providing …

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Nonlinear Model Predictive Control Of Heaving Wave Energy Converter With Nonlinear Froude–Krylov Forces, Tania Demonte Gonzalez, Enrico Anderlini, Houssein Yassin, Gordon Parker Oct 2024

Nonlinear Model Predictive Control Of Heaving Wave Energy Converter With Nonlinear Froude–Krylov Forces, Tania Demonte Gonzalez, Enrico Anderlini, Houssein Yassin, Gordon Parker

Michigan Tech Publications

Wave energy holds significant promise as a renewable energy source due to the consistent and predictable nature of ocean waves. However, optimizing wave energy devices is essential for achieving competitive viability in the energy market. This paper presents the application of a nonlinear model predictive controller (MPC) to enhance the energy extraction of a heaving point absorber. The wave energy converter (WEC) model accounts for the nonlinear dynamics and static Froude–Krylov forces, which are essential in accurately representing the system’s behavior. The nonlinear MPC is tested under irregular wave conditions within the power production region, where constraints on displacement and …

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Development And Evaluation Of A Colorimetric Lamp Based-Assay Targeting The Bacteroides Hf183 Marker For Tracking Sewage Pollution In Environmental Waters, Mariah C.A. Do Nascimento, Wendy J.M. Smith, Metasebia Gebrewold, Yawen Liu, Stuart L. Simpson, Aaron Bivins, Paula Rahal, Warish Ahmed Oct 2024

Development And Evaluation Of A Colorimetric Lamp Based-Assay Targeting The Bacteroides Hf183 Marker For Tracking Sewage Pollution In Environmental Waters, Mariah C.A. Do Nascimento, Wendy J.M. Smith, Metasebia Gebrewold, Yawen Liu, Stuart L. Simpson, Aaron Bivins, Paula Rahal, Warish Ahmed

Faculty Publications

Surface waters are vulnerable to contamination by human and animal feces, posing risks to human health due to potential exposure to enteric pathogens. This research developed a colorimetric loop-mediated isothermal amplification (cLAMP) assay to detect sewage associated Bacteroides dorei HF183/BacR287 (HF183) marker in wastewater and environmental water samples. The host sensitivity and host specificity of the assay were evaluated, and their performance was compared to the Bacteroides HF183 qPCR assay using control materials (gBlocks), environmental water samples seeded with untreated sewage, and ambient environmental water samples. In serial dilutions of control materials, qPCR produced quantifiable data across all dilutions, while …

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Asphalt Binder Laboratory Short-Term Aging - Phase Ii, Farzad Yazdipanah, Ahmad Muhammad, Zahra Kamali Khanghah, Mahdieh Khedmati, Jamilla Teixeira, Mohammad Ghashami, Hamzeh Haghshenas Oct 2024

Asphalt Binder Laboratory Short-Term Aging - Phase Ii, Farzad Yazdipanah, Ahmad Muhammad, Zahra Kamali Khanghah, Mahdieh Khedmati, Jamilla Teixeira, Mohammad Ghashami, Hamzeh Haghshenas

Nebraska Department of Transportation: Research Reports

This study examined the effectiveness of laboratory short-term aging processes for warm mix asphalt (WMA) binders using response surface methodology (RSM) with various combinations of aging parameters: time, temperature, airflow, and binder weight. The research aimed to enhance understanding of aging parameter efficacy and propose a modified laboratory short-term aging protocol that accurately simulates plant short-term aging in WMA binders. Additionally, the study explored the potential of thermal simulation techniques to model the heat transfer within asphalt mixtures during the compaction procedure. To achieve these goals, three WMA mixtures produced at 135 ºC were collected from plants, and their asphalt …

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Ole Miss Partners With Texas A&M, Virginia Tech For Novel Ai Study, Clara Turnage Oct 2024

Ole Miss Partners With Texas A&M, Virginia Tech For Novel Ai Study, Clara Turnage

University of Mississippi News

OXFORD, Miss. – Colleges and universities across the globe are grappling with artificial intelligence without a consensus on how best to approach one of the fastest-growing technologies of the era.

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Science, Technology, And Magic In The Witcher: A Medievalist Spin On Modern Monsters, By Kristine Larsen, Amber Lehning Oct 2024

Science, Technology, And Magic In The Witcher: A Medievalist Spin On Modern Monsters, By Kristine Larsen, Amber Lehning

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

This article critiques Kristine Larsen’s Science, Technology, and Magic in THE WITCHER: A Medievalist Spin on Modern Monsters. Larsen’s wide-ranging discussion views the Witcherverse through several critical lenses and explores the ways this modern myth speaks to some important questions of ethics, science, and philosophy. The review evaluates Larsen’s coverage of the full expanse of the transmedia Witcher phenomenon.

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Modeling Method Of Blue Army Warship Formation Air Defense Command And Control For System-Of-Systems Simulation, Shikang Chen, Zhimin Wang, Biao Liang, Kunren Gu, Keman Song, Yuan Gao Oct 2024

Modeling Method Of Blue Army Warship Formation Air Defense Command And Control For System-Of-Systems Simulation, Shikang Chen, Zhimin Wang, Biao Liang, Kunren Gu, Keman Song, Yuan Gao

Journal of System Simulation

Abstract: The command and control of warship formation air defense is a key link for the blue army's sea to air combat tasks and the modeling of air defense for warship formation is an important component of simulation modeling of blue army's maritime combat system. Based on the background of system-of-systems simulation, the air defense command and control modeling for blue army is designed. Through a modular modeling method, functional module including asset management and plan, unified situation generation, command decision are designed. According to blue army's command and control logic, these modules are integrated and the air defense command …

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Two-Level Optimal Dispatch Of Power System Based On Load-Storage Carbon Flow Model, Yang Yu, Yuxing Xia, Wentao Lu, Mai Liu, Shixu Gao, Dongyang Chen Oct 2024

Two-Level Optimal Dispatch Of Power System Based On Load-Storage Carbon Flow Model, Yang Yu, Yuxing Xia, Wentao Lu, Mai Liu, Shixu Gao, Dongyang Chen

Journal of System Simulation

Abstract: In order to reduce the output of high energy consuming units on the power generation side, increase the absorption capacity of wind power, and consider the flexible resource allocation such as load and energy storage, a two-level economic low-carbon optimal scheduling method for power systems based on a carbon storage and discharge model is proposed. Based on the carbon emission flow theory of power system, a model for load and energy storage equipment is established; A demand response model based on the electricity carbon coupling price is established on the load side, and in view of the limitation on …

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Chaotic-Encode Quantum Pso Algorithm For Flexible Job-Shop Scheduling Problem, Yuanxing Xu, Mengjian Zhang, Deguang Wang Oct 2024

Chaotic-Encode Quantum Pso Algorithm For Flexible Job-Shop Scheduling Problem, Yuanxing Xu, Mengjian Zhang, Deguang Wang

Journal of System Simulation

Abstract: To solve the flexible job-shop scheduling problem (FJSP), a chaotic-encode quantum PSO (CQPSO) algorithm is proposed. Aiming at the premature convergence of particles to local optimum in standard QPSO, the methods for computing the adaptive contraction-expansion coefficient and mean best position using fitness values of associated particles are proposed to improve the global search ability of QPSO. Through chaotic boundary variation strategy, the probability of a large number of particles gathering at the boundary is reduced and the population diversity is increased to enhance the ability of searching the optimal solution. According to the iterative property of QPSO, a …

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Multi-Strategy Partheno-Genetic Algorithm Based On Dynamic Reduction Mechanism For Solving Cvrp Problem, Jiajun Chen, Dailun Tan Oct 2024

Multi-Strategy Partheno-Genetic Algorithm Based On Dynamic Reduction Mechanism For Solving Cvrp Problem, Jiajun Chen, Dailun Tan

Journal of System Simulation

Abstract: Aiming at the problems of premature, slow convergence and low accuracy of traditional genetic algorithm in solving capacitated vehicle routing problem,a multi-strategy partheno-genetic algorithm based on dynamic reduction mechanism is proposed. The algorithm divides the optimization space based on similar individuals, and uses simulated annealing criterion to eliminate or update the lowest category subspace, which constitutes the reduction and movement mechanism of the optimization space. Based on parthenogenetic algorithm,a variety of genetic evolution strategies including intra-group, inter-group, global search, disturbance and jump strategy are designed Based on the three penalty factors of individual development, population evolution and overall convergence, …

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Unmanned Vehicle Path Planning And Tracking Control Based On Improved Artificial Potential Field Method, Minghao Guo, Peng Ji, Haiwei Huang Oct 2024

Unmanned Vehicle Path Planning And Tracking Control Based On Improved Artificial Potential Field Method, Minghao Guo, Peng Ji, Haiwei Huang

Journal of System Simulation

Abstract: A path planning algorithm based on improved artificial potential field method and a tracking control strategy based on model predictive controller are proposed for the unmanned vehicle avoiding dynamic obstacles in the complex scene of lane changing and overtaking. The theory of safety ellipse and the concept of prediction distance are introduced to adjust the influence region of potential field. By adding velocity potential field to change potential field function, the problem of vehicle avoiding dynamic obstacles is solved. Based on the linear three-degree-of-freedom vehicle dynamics model, a model prediction controller including potential field environment is established. The effectiveness …

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Representing Middle-Earth: Tolkien, Form, And Ideology, By Robert T. Tally, Jr, Norbert Schürer Oct 2024

Representing Middle-Earth: Tolkien, Form, And Ideology, By Robert T. Tally, Jr, Norbert Schürer

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

No abstract provided.

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Spatial And Temporal Variations Of Seismic Azimuthal Anisotropy Following The 2019 Ridgecrest Earthquake Sequence In Southern California, Yan Jia, Stephen S. Gao, Kelly H. Liu Oct 2024

Spatial And Temporal Variations Of Seismic Azimuthal Anisotropy Following The 2019 Ridgecrest Earthquake Sequence In Southern California, Yan Jia, Stephen S. Gao, Kelly H. Liu

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

To investigate the spatial and temporal variations of seismic azimuthal anisotropy in the vicinity of the conjugate fault network activated by the 4 July 2019 (UTC) M6.4 foreshock and the 6 July 2019 M7.1 mainshock in Ridgecrest, California, a total of 1,470 shear wave splitting measurements were obtained from local events recorded by five seismic stations over the period of July 2019 to January 2020. The results suggest a strong asymmetry in anisotropy forming mechanisms across the NW-SE striking Eastern Little Lake Fault, which is the main fault of the area. In the area located to the northeast of the …

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Search Technology For Aircraft Debris Integrating Data Augmentation And Deep Learning Algorithm, Zhe Yang, Yinghan Cui, Lingxi Guo, Jiaxin Li, Xusheng Wu Oct 2024

Search Technology For Aircraft Debris Integrating Data Augmentation And Deep Learning Algorithm, Zhe Yang, Yinghan Cui, Lingxi Guo, Jiaxin Li, Xusheng Wu

Journal of System Simulation

Abstract: The reliable recovery of aircraft debris is of great significance for the complete acquisition of flight test data and the subsequent research and development of models. To ensure the safety of flight tests,the landing area of aircraft experiments is generally an unmanned area,and the actual landing point of the aircraft often deviates from the theoretical landing point. The characteristics of the debris target are complex and the dispersion area is large, making it difficult to search for aircraft debris solely by manpower. Aiming at the difficult problem of aircraft debris recovery in the landing area, through on UAV platforms …

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Research On Flexible Operational Optimization Of Cchp System Based On Intelligent Fusion Algorithm, Zhe Bao, Xiaofang Zhang, Wei Li, Ye Xu, Xu Wang Oct 2024

Research On Flexible Operational Optimization Of Cchp System Based On Intelligent Fusion Algorithm, Zhe Bao, Xiaofang Zhang, Wei Li, Ye Xu, Xu Wang

Journal of System Simulation

Abstract: To further improve the accuracy of gas turbine simulation models, based on the construction of a gas turbine mechanism simulation model and BP simulation model, through model substitution technology and BP neural network algorithm three intelligent fusion simulation models for gas turbines, and two intelligent fusion simulation models for parallel gas turbines are constructed respectively as well as the combination of, by comparing the simulated results of the above models with the actual operating data, the simulation model with the best performance was selected. Using the intelligent fusion simulation model of the gas turbine as the output constraint, a …

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A Method For Battlefield Situation Information Ontology Construction Based On Top-Down And Bottom-Up Integration, Cong Zhou, Sihang Zhou, Jian Huang, Dong Wang Oct 2024

A Method For Battlefield Situation Information Ontology Construction Based On Top-Down And Bottom-Up Integration, Cong Zhou, Sihang Zhou, Jian Huang, Dong Wang

Journal of System Simulation

Abstract: The construction of the unified expression model of battlefield situational information is challenging due to the complexity of data sources and the significant differences in data structures and expression methods. Ontologies, as semantic conceptual models, are often used to describe concepts, relationships, and attributes within knowledge domains. An ontology construction method for the battlefield situational information domain based on a top-down and bottom-top integration is proposed. The top-down method is used to construct the upper ontology, in which a conceptual hierarchy model with a clear top-down structure is designed to establish the hierarchical relationships and semantic associations. A bottom-up …

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Research On Digital Twin Technology Of Coal Mine Tunneling Machine System, Xingwang Cai, Yaoqiang Pei, Jihua Yang, Ruifeng Pang Oct 2024

Research On Digital Twin Technology Of Coal Mine Tunneling Machine System, Xingwang Cai, Yaoqiang Pei, Jihua Yang, Ruifeng Pang

Journal of System Simulation

Abstract: Aiming at the problems in coal mine tunneling operations, including complex geological structures, harsh on-site conditions, low automation of excavation equipment, and frequent safety incidents, a digital twin solution is proposed. PLC as hardware core, MQTT protocol, and EMQX as foundation, through the integration of IoT, internet, digital twins, and virtual reality technologies, the mapping rules for parameter matrices and a fault cause analysis table are established, which realize the functions such as data collection, processing during excavation, data mapping between equipment and twin models, data storage, process simulation, remote control, intelligent fault detection, and early warning, and significantly …

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Antibiofilm Activity Of Pdms/Tio2 Against Candida Glabrata Through Inhibited Hydrophobic Recovery, Khoi Nguyen Nguyen, Leena Sao, Kevin Kyllo, Danitza Hernandez, Samantha Salomon, Kalp Shah, Dahyun Oh, Katy C. Kao Oct 2024

Antibiofilm Activity Of Pdms/Tio2 Against Candida Glabrata Through Inhibited Hydrophobic Recovery, Khoi Nguyen Nguyen, Leena Sao, Kevin Kyllo, Danitza Hernandez, Samantha Salomon, Kalp Shah, Dahyun Oh, Katy C. Kao

Faculty Research, Scholarly, and Creative Activity

Coatings with antibiofilm properties are desirable for biomedical applications. Titanium dioxide (TiO2) has been explored as an antimicrobial agent in materials development primarily due to it being an excellent photocatalyst. Candida glabrata (C. glabrata) is an emerging human fungal pathogen with known high resistance to oxidative stress. Here, we fabricated a polydimethylsiloxane/titanium dioxide (PDMS/TiO2) nanocomposite coating and tested its antibiofilm activities against C. glabrata. The resulting nanocomposite exhibited >50% reduction in C. glabrata biofilm formation with 2.5 wt % TiO2 loading, even in the dark. Through ROS detection and surface characterization, the antibiofilm activity was attributed to the synergistic interaction …

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Cover And Contents Oct 2024

Cover And Contents

Turkish Journal of Biology

No abstract provided.

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Correction Of Griscelli Syndrome Type 2 Causing Mutations In The Rab27a Gene With Crispr/Cas9, Özgür Doğuş Erol, Şi̇mal Şenocak, Burcu Özçi̇men, Gülen Güney Esken, Hasan Basri̇ Kiliç, Yusuf Çeti̇n Kocaefe, Niek Peter Van Til, Fatima Aerts Kaya Oct 2024

Correction Of Griscelli Syndrome Type 2 Causing Mutations In The Rab27a Gene With Crispr/Cas9, Özgür Doğuş Erol, Şi̇mal Şenocak, Burcu Özçi̇men, Gülen Güney Esken, Hasan Basri̇ Kiliç, Yusuf Çeti̇n Kocaefe, Niek Peter Van Til, Fatima Aerts Kaya

Turkish Journal of Biology

Background/aimGriscelli Syndrome Type 2 (GS-2) is a rare, inherited immune deficiency caused by a mutation in the RAB27A gene. Current treatment consists of hematopoietic stem cell transplantation. Lack of suitable donors warrants the development of alternative treatment strategies, including gene therapy. The development of mutation-specific CRISPR/Cas9 gene editing technology has opened the way for custom designed gene correction of patient-derived stem cells. Here, we aimed to custom design CRISPR/Cas9 constructs and test their efficiency of homology directed repair (HDR) on the correction of exon 3 and exon 7 mutations in the RAB27A gene of GS-2 patient-derived mesenchymal stem cells (MSCs) …

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Delivery Of Bikdd Proapoptotic Gene In Peptide-18 Targeted Poly(2-Oxazoline)-Dope Nanoliposomes For Breast Cancer Models, Zeynep Büşra Bolat, Ayça Ece Nezi̇r, Ongun Mehmet Saka, Itir Ebru Zemheri̇, Sevgi̇ Gülyüz, Umut Uğur Özköse, Özgür Yilmaz, Asuman Bozkir, Di̇lek Telci̇, Fi̇kretti̇n Şahi̇n Oct 2024

Delivery Of Bikdd Proapoptotic Gene In Peptide-18 Targeted Poly(2-Oxazoline)-Dope Nanoliposomes For Breast Cancer Models, Zeynep Büşra Bolat, Ayça Ece Nezi̇r, Ongun Mehmet Saka, Itir Ebru Zemheri̇, Sevgi̇ Gülyüz, Umut Uğur Özköse, Özgür Yilmaz, Asuman Bozkir, Di̇lek Telci̇, Fi̇kretti̇n Şahi̇n

Turkish Journal of Biology

Breast cancer is the most common cancer type and the major cause of death in females worldwide. For effective breast cancer treatment, systems with promising delivery of anticancer agents is an important strategy. Peptide 18 (P18), a tumor homing peptide, shows high binding affinity towards breast cancer cells. Nanoliposomes are known to have enhanced accumulation ability in tumors with longer systemic circulation. Poly (2-ethyl-2-oxazoline) (PEtOx) polymers conjugated with DOPE were used to prepare PEtOx-DOPE nanoliposomes. BikDD is a mutant form of Bik gene, a member of the BH3-only proapoptotic genes, mimics the constitutively phosphorylated form of the gene. To the …

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Pterostilbene Suppresses Head And Neck Cancer Cell Proliferation Via Induction Of Apoptosis, Tali̇h Özdaş, Si̇bel Özdaş, İpek Canatar, Erdem Kaypak Oct 2024

Pterostilbene Suppresses Head And Neck Cancer Cell Proliferation Via Induction Of Apoptosis, Tali̇h Özdaş, Si̇bel Özdaş, İpek Canatar, Erdem Kaypak

Turkish Journal of Biology

Background/aim: Head and neck cancer (HNC) is one of the most prevalent causes of death worldwide, and the discovery of anticancer agents for its prevention is very important. Pterostilbene (PS) is a trans-stilbene reported to be beneficial in managing various cancers. The objective of the study was to evaluate the cytotoxic, anti-proliferative, pro-apoptotic and anti-migrative effect of PS on HEp-2, SCC-90, SCC-9, FaDu and Detroit-551 cell lines. Materials and Methods: MTT and live/dead assays were employed to assess cell-viability, while cell migration test was performed to evaluate wound healing capacity. The mRNA, protein and intracellular expression level of CASP-3, BAX …

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Optical Imaging And Gene Transfection Potential Of Linear Polyethylenimine Coated Ag2s Near-Infrared Quantum Dots, Altay Savalan Oct 2024

Optical Imaging And Gene Transfection Potential Of Linear Polyethylenimine Coated Ag2s Near-Infrared Quantum Dots, Altay Savalan

Turkish Journal of Biology

Background/aimApplication of biocompatible heavy metal free and cationic Ag2S NIR QDs, which are highly luminesce in the medical range (700-900 nm), as a non-viral gene delivery system paves the way to overcome the auto-fluorescence and easily track the delivery of the genes in real time as it happens.Materials and methodsHere, the newly developed small and colloidally stable 2-mercaptopropionic acid (MPA)-capped Ag2S aqueous quantum dots electrostatically complexed with linear polyethyleneimine (LPEI) (Ag2S@2MPA/LPEI) was investigated for the first time both as a strong fluorescent probe and as a non-viral gene delivery vector for the highest tracking of the system and delivery of …

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