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Single Nanobubble Formation On Au Nanoelectrodes And Au@Ws2 Nanoelectrodes: Voltammetric Analysis And Electrocatalysis, Xian-Zhun Luo, Xiao-Hu Chen, Yong-Xin Li Oct 2024

Single Nanobubble Formation On Au Nanoelectrodes And Au@Ws2 Nanoelectrodes: Voltammetric Analysis And Electrocatalysis, Xian-Zhun Luo, Xiao-Hu Chen, Yong-Xin Li

Journal of Electrochemistry

Taking advantage of the extremely small size of the gold nanodisk electrode, the single hydrogen nanobubble generated on the surface of the nanoelectrode was studied to evaluate its hydrogen evolution performance. It was found that compared with the bare gold nanodisk electrode, the bubble formation potential of the gold nanodisk electrode modified with tungsten disulfide quantum dots (WS2 QDs) on the surface was more positive, indicating that its hydrogen evolution activity was higher. Microdynamic model analysis shows that the average standard rate constant of the rate-determining step of the hydrogen evolution reaction of gold nanoelectrodes modified with WS2 …


Platinum Nanoparticle-Based Collision Electrochemistry For Rapid Detection Of Breast Cancer Mcf-7 Cells, Fu-Xing Qin, Ming-Ke Li, Hui-Long Zhou, Wei Wen, Xiu-Hua Zhang, Sheng-Fu Wang, Zhen Wu Oct 2024

Platinum Nanoparticle-Based Collision Electrochemistry For Rapid Detection Of Breast Cancer Mcf-7 Cells, Fu-Xing Qin, Ming-Ke Li, Hui-Long Zhou, Wei Wen, Xiu-Hua Zhang, Sheng-Fu Wang, Zhen Wu

Journal of Electrochemistry

Cancer metastasis is the leading cause of death in cancer patients worldwide and one of the major challenges in treating cancer. Circulating tumor cells (CTCs) play a pivotal role in cancer metastasis. However, the content of CTCs in peripheral blood is minimal, so the detection of CTCs in real samples is extremely challenging. Therefore, efficient enrichment and early detection of CTCs are essential to achieve timely diagnosis of diseases. In this work, we constructed an innovative and sensitive single-nanoparticle collision electrochemistry (SNCE) biosensor for the detection of MCF-7 cells (human breast cancer cells) by immunomagnetic separation technique and liposome signal …


Highly Sensitive Detection Of Strontium Ions Using Metal-Organic Frameworks Functionalized Solid-State Nanochannels, Xu-Gang Wang, Zheng-Xu He, De-Fang Ding, Xue-Qin Luo, Li Dai, Wei-Qi Zhang, Qun Ma, Yu Huang, Fan Xia Oct 2024

Highly Sensitive Detection Of Strontium Ions Using Metal-Organic Frameworks Functionalized Solid-State Nanochannels, Xu-Gang Wang, Zheng-Xu He, De-Fang Ding, Xue-Qin Luo, Li Dai, Wei-Qi Zhang, Qun Ma, Yu Huang, Fan Xia

Journal of Electrochemistry

Strontium-90, a highly radioactive isotope, accumulates within the food chain and skeletal structure, posing significant risks to human health. There is a critical need for a sensitive detection strategy for Strontium-90 in complex environmental samples. Here, solid-state nanochannels, modified with metal-organic frameworks (MOF) and specific aptamers, were engineered for highly sensitive detection of strontium ion (Sr2+). The synergistic effect between the reduced effective diameter of the nanochannels due to MOF and the specific binding of Sr2+ by aptamers amplifies the difference in ionic current signals, enhancing detection sensitivity significantly. The MOF-modified nanochannels exhibit highly sensitive detection of …


The Adviser Of Journal Of Electrochemistry Professor Christian Amatore Received The Chinese Government Friendship Award, Editorial Office Of J.Electrochem. Oct 2024

The Adviser Of Journal Of Electrochemistry Professor Christian Amatore Received The Chinese Government Friendship Award, Editorial Office Of J.Electrochem.

Journal of Electrochemistry

No abstract provided.


The Role Of Cybersecurity In Bioinformatics For Aviation And Aerospace Safety, Sharon L. Burton Oct 2024

The Role Of Cybersecurity In Bioinformatics For Aviation And Aerospace Safety, Sharon L. Burton

Publications

The intersection of bioinformatics and cybersecurity is critical to ensuring the privacy, integrity, and safety of biological data [1]. Bioinformatics is an interdisciplinary field that embodies the cyber age through its reliance on sophisticated algorithms, cloud computing, and secure data management practices, reflecting the profound digital transformation across various scientific disciplines [2].


Optimizing In-Situ Upgrading Of Heavy Crude Oil Via Catalytic Aquathermolysis Using A Novel Graphene Oxide-Copper Zinc Ferrite Nanocomposite As A Catalyst, Attia Attia, Ahmed Ashraf Soliman Eng., Mostafa Aboul-Fetouh Prof., Sayed Gomaa Prof., Tarek Aboul-Fotouh Prof. Oct 2024

Optimizing In-Situ Upgrading Of Heavy Crude Oil Via Catalytic Aquathermolysis Using A Novel Graphene Oxide-Copper Zinc Ferrite Nanocomposite As A Catalyst, Attia Attia, Ahmed Ashraf Soliman Eng., Mostafa Aboul-Fetouh Prof., Sayed Gomaa Prof., Tarek Aboul-Fotouh Prof.

Petroleum Engineering and Gas

Unconventional resources, such as heavy oil, are increasingly being explored and exploited due to the declining availability of conventional petroleum resources. Heavy crude oil poses challenges in production, transportation, and refining, due to its high viscosity, low API gravity, and elevated sulfur and metal content. Improving the quality of heavy oil can be achieved through the application of steam injection, which lowers the oil’s viscosity and enhances its flow. However, steam injection alone falls short of meeting the growing demand for higher-quality petroleum products. Catalytic upgrading is therefore being investigated as a viable solution to improve heavy oil quality. This …


Assessing The Effectiveness Of Chatbots In Providing Personalized Academic Advising And Support To Higher Education Students: A Narrative Literature Review, Manal Dawood Oct 2024

Assessing The Effectiveness Of Chatbots In Providing Personalized Academic Advising And Support To Higher Education Students: A Narrative Literature Review, Manal Dawood

All Works

Academic advising is essential for university and college students to achieve success since it provides guidance in many aspects of their academic journey. According to Drake (2011), having a solid relationship with an academic advisor is necessary for students to succeed in university settings. Students often have questions about university policies, processes, and resources, and they seek assistance from their academic advisors, who may be lecturers or other staff members. However, these demands can sometimes overwhelm the advisors. Although modern technology has reduced these demands (Ghonmein et al., 2023), advisors continue to face challenging tasks. Artificial Intelligence (AI) conversational agents …


Bipolar Ionization Did Not Reduce Airborne Bacteria In A Lecture Hall, David A. Kormos, Nishit J. Shetty, Elliott T. Gall, Aaron J. Prussin, Amy Pruden, Linsey C. Marr Oct 2024

Bipolar Ionization Did Not Reduce Airborne Bacteria In A Lecture Hall, David A. Kormos, Nishit J. Shetty, Elliott T. Gall, Aaron J. Prussin, Amy Pruden, Linsey C. Marr

Mechanical and Materials Engineering Faculty Publications and Presentations

Ionization treatment of indoor air has attracted attention for its potential to inactivate airborne pathogens and reduce disease transmission, yet its real-world effectiveness remains unverified. We evaluated the impact of an in-duct, bipolar ionization system on airborne particles, including culturable bacteria, in a lecture hall. The ionizer was off with variable fan speed for 1 week, on with variable fan speed for a second week, and on with high and constant fan speed for a third week. We measured ion concentrations and aerosol particle concentrations, and we collected bioaerosol samples for analysis of 16S rRNA gene copies representing total bacteria …


Engineered Cas9 Variants Bypass Keap1-Mediated Degradation In Human Cells And Enhance Epigenome Editing Efficiency, Jianfeng Chen, Siyuan Su, Adrian Pickar-Oliver, Anna M Chiarella, Quentin Hahn, Dennis Goldfarb, Erica W Cloer, George W Small, Smaran Sivashankar, Dale A Ramsden, Michael B Major, Nathaniel A Hathaway, Charles A Gersbach, Pengda Liu Oct 2024

Engineered Cas9 Variants Bypass Keap1-Mediated Degradation In Human Cells And Enhance Epigenome Editing Efficiency, Jianfeng Chen, Siyuan Su, Adrian Pickar-Oliver, Anna M Chiarella, Quentin Hahn, Dennis Goldfarb, Erica W Cloer, George W Small, Smaran Sivashankar, Dale A Ramsden, Michael B Major, Nathaniel A Hathaway, Charles A Gersbach, Pengda Liu

2020-Current year OA Pubs

As a potent and convenient genome-editing tool, Cas9 has been widely used in biomedical research and evaluated in treating human diseases. Numerous engineered variants of Cas9, dCas9 and other related prokaryotic endonucleases have been identified. However, as these bacterial enzymes are not naturally present in mammalian cells, whether and how bacterial Cas9 proteins are recognized and regulated by mammalian hosts remain poorly understood. Here, we identify Keap1 as a mammalian endogenous E3 ligase that targets Cas9/dCas9/Fanzor for ubiquitination and degradation in an 'ETGE'-like degron-dependent manner. Cas9-'ETGE'-like degron mutants evading Keap1 recognition display enhanced gene editing ability in cells. dCas9-'ETGE'-like degron …


Targeting Trem2 Signaling Shows Limited Impact On Cerebrovascular Calcification, Sucheta Sridhar, Yingyue Zhou, Adiljan Ibrahim, Sergio Bertazzo, Tania Wyss, Amanda Swain, Upasana Maheshwari, Sheng-Fu Huang, Marco Colonna, Annika Keller Oct 2024

Targeting Trem2 Signaling Shows Limited Impact On Cerebrovascular Calcification, Sucheta Sridhar, Yingyue Zhou, Adiljan Ibrahim, Sergio Bertazzo, Tania Wyss, Amanda Swain, Upasana Maheshwari, Sheng-Fu Huang, Marco Colonna, Annika Keller

2020-Current year OA Pubs

Brain calcification, the ectopic mineral deposits of calcium phosphate, is a frequent radiological finding and a diagnostic criterion for primary familial brain calcification. We previously showed that microglia curtail the growth of small vessel calcification via the triggering receptor expressed in myeloid 2 (TREM2) in the


Joint Modeling Of Degradation Signals And Time-To-Event Data For The Prediction Of Remaining Useful Life, Sebastian Brumm, Erik Linstead, Junde Chen, Narayanaswamy Balakrishnan, Yuxin Wen Oct 2024

Joint Modeling Of Degradation Signals And Time-To-Event Data For The Prediction Of Remaining Useful Life, Sebastian Brumm, Erik Linstead, Junde Chen, Narayanaswamy Balakrishnan, Yuxin Wen

Engineering Faculty Articles and Research

Accurate prediction of remaining useful life (RUL) for in-service systems plays an important role in ensuring efficient operation of industrial equipment and in preventing unexpected equipment failures. In this paper, we present a prognostic framework for real-time RUL prediction based on joint modeling of both degradation signals and time-to-event data. The proposed model employs a change point-based general path model to capture signal non-linearity and Neural network (NN) based Cox model to link the time-to-event data with the estimated degradation trend. An empirical two-step scheme for hyperparameter estimation is proposed to enhance prognostic accuracy. Furthermore, an efficient Bayesian model updating …


Exploring The Interconnectivity Between Soilless Substrate Hydraulic Properties And Plant Root Morphology, Kristopher S. Criscione Oct 2024

Exploring The Interconnectivity Between Soilless Substrate Hydraulic Properties And Plant Root Morphology, Kristopher S. Criscione

LSU Doctoral Dissertations

Horticultural container production heavily relies upon porous soilless substrates to mass produce specialty crops. Soilless substrates are responsible for continuously maintaining optimal water, mineral nutrients, and air balances to promote healthy root growth and support productive shoot yield (foliage or fruit). Increasing evidence of substrate research continues to highlight the strong relationships associated with root development and substrate physiochemical properties. Despite the importance of the root system for overall plant health, most horticultural research to-date has focused on shoot development. Research tends to report total root biomass as the primary root-growth metric; however, this results in several developmental features becoming …


Evidencing The Challenges Of Care Delivery For People With Intellectual Disability And Epilepsy In England By Using The Step Together Toolkit, Rohit Shankar, Georgia Page, Bridie Kent Oct 2024

Evidencing The Challenges Of Care Delivery For People With Intellectual Disability And Epilepsy In England By Using The Step Together Toolkit, Rohit Shankar, Georgia Page, Bridie Kent

Peninsula Medical School

BackgroundPeople with intellectual disability (PwID) and epilepsy have increased premature and potentially preventable mortality. This is related to a lack of equitable access to appropriate care. The Step Together guidance and toolkit, developed with patient, clinical, charity and commissioning stakeholders, allows evaluation and benchmarking of essential epilepsy service provision for PwID in eight key domains, at a care system level.AimsTo evaluate care provisions for adult PwID and epilepsy at a system level in the 11 integrated care systems (ICSs) of the Midlands, the largest NHS England region (population: approximately 11 million), using the Step Together toolkitMethodPost training, each ICS undertook …


Goodbye With Tears! Deep Condolences To Academician Zhao-Wu Tian!, Editorial Office Of J.Electrochem. Oct 2024

Goodbye With Tears! Deep Condolences To Academician Zhao-Wu Tian!, Editorial Office Of J.Electrochem.

Journal of Electrochemistry

No abstract provided.


Journal Of Electrochemistry Is Selected To Entering Ici Journals Master List, Editorial Office Of J.Electrochem. Oct 2024

Journal Of Electrochemistry Is Selected To Entering Ici Journals Master List, Editorial Office Of J.Electrochem.

Journal of Electrochemistry

No abstract provided.


Multi-Modal Contextual Search For Enterprise Content, Adam Sabra, Rekha Gopikrishnan, Altanai Bisht, Hazim Dahir, Karthik Babu Harichandra Babu, Savita Kini Oct 2024

Multi-Modal Contextual Search For Enterprise Content, Adam Sabra, Rekha Gopikrishnan, Altanai Bisht, Hazim Dahir, Karthik Babu Harichandra Babu, Savita Kini

Defensive Publications Series

A multi-modal contextual search system is proposed herein that may revolutionize multimedia content retrieval in collaborative environments. Unlike traditional keyword-based searches, the proposed system employs advanced artificial intelligence (AI) techniques to directly search within audio and video files in order to retrieve content, overcoming transcription limitations. By leveraging neural-encoder inspired embedding systems and AI-powered audio search without transcription, the proposed system ensures swift and accurate access to crucial information, enhancing productivity and knowledge dissemination. With enhanced features such as audio metadata extraction and semantic matching, the innovative solution proposed herein offers a comprehensive and contextually relevant search experience tailored for …


Volume 46-2 Complete Issue, Lawrence Handley Oct 2024

Volume 46-2 Complete Issue, Lawrence Handley

The Geographical Bulletin

Volume 46-2 Complete Issue


In Memoriamc. Nicholas Raphael (1937–2004), Robert M. Ward, Carl F. Ojala Oct 2024

In Memoriamc. Nicholas Raphael (1937–2004), Robert M. Ward, Carl F. Ojala

The Geographical Bulletin

February 21, 2004 was a sad day for all of us acquainted with C. Nicholas Raphael. On that morning, at age 66, he passed away suddenly, leaving a community he loved and one which loved him. Nick had been our dear friend and colleague for more than three decades. He will be remembered by many in the geographical profession as the editor of Gamma Theta Upsilon’s The Geographical Bulletin, a position he proudly occupied since 1987. Nick began a productive and fruitful life as the son of R. George and Angela Raphael on September 3, 1937, in Detroit, Michigan. He …


Volume 47-2 Complete Issue, Steven M. Schnell Oct 2024

Volume 47-2 Complete Issue, Steven M. Schnell

The Geographical Bulletin

Volume 47-2 Complete Issue


Adapting To Drought And Floods In The Semi-Arid Landscape Of Santa Cruz County, Arizona, Cynthia L. Sorrensen Oct 2024

Adapting To Drought And Floods In The Semi-Arid Landscape Of Santa Cruz County, Arizona, Cynthia L. Sorrensen

The Geographical Bulletin

This paper analyzes the actions of key interest groups and major institutional regulatory agreements that influence land use change and water demand in Santa Cruz County, Arizona, in order to better understand the capacity of residents in the county to adapt to hydroclimatic hazards (drought and flooding). We found that there are strong special interest groups working in the region to ensure their own livelihoods and interests. At times, the actions of these groups enhance the adaptive capacity of the county, but their actions can also conflict with each other, producing a less-clear outcome for adaptation. We also note that …


Geographer At Work: Frank Salmon, Gis Manager, Leon Yacher Oct 2024

Geographer At Work: Frank Salmon, Gis Manager, Leon Yacher

The Geographical Bulletin

Frank Salmon remembers to the day when he decided Geography was going to be his career. Frank had just taken his seat before his first Geography final exam at Gateway Community Technical College when the professor announced to the class that “any of you who liked this course and want to pursue this as a major at Southern Connecticut State, I will guarantee that you will have a career when you graduate.” Not that Frank really needed this persuasion; he had loved Geography since he was a child. This first Geography class simply articulated for him what he now believes …


Water Woes: Structure And Agency Influences On Adaptive Capacity In Southwest Kansas, Rorik Ford Peterson Oct 2024

Water Woes: Structure And Agency Influences On Adaptive Capacity In Southwest Kansas, Rorik Ford Peterson

The Geographical Bulletin

Concerns over the continual reduction of available groundwater in southwest Kansas have been increasing. This concern is compounded by the high dependence on irrigated agriculture and the related agribusiness industry, which is a staple to the regional economy and employs a large labor force. Future climate variation may enhance the sensitivity of the region to limited water availability. Through archival research and interviews, this study examines the impact of both structural forces (such as policy makers and legal bodies) and individual agents (local farmers, ranchers, and other citizens) on the capacity of southwest Kansas to adapt to climate variation. Although …


A Veteran Mental Health Approach Sustaining Identity Post-Military Life: A Comprehensive Overview, Darren Sosa, Lindsay Gietzen Oct 2024

A Veteran Mental Health Approach Sustaining Identity Post-Military Life: A Comprehensive Overview, Darren Sosa, Lindsay Gietzen

Pacific Journal of Health

Veterans and their mental health face readjustment challenges based on veteran identity, intersectionality, and experiences from their time serving in the military. This comprehensive overview and PRISMA analysis investigate the current evidence-based practices of veterans' identity and intersectionality. Specifically, psychoeducation and evidence-based practices for veterans readjusting back into their communities. A gap identified in this research’s findings calls for suggestions for future research on the veteran population and intersectionality. No specific psychoeducation or evidence-based practices tailored for identity readjustment or veteran intersectionality were found. This research constructs a tailored framework of suggestions for current and future evidence-based practices for the …


Lived Experiences Of Low-Income African American Burn Survivors In Greater Washington, Dc, Angela White Oct 2024

Lived Experiences Of Low-Income African American Burn Survivors In Greater Washington, Dc, Angela White

Walden Dissertations and Doctoral Studies

Burn injuries are wounds that affect the skin and other organic tissue, categorized according to the mechanism of injury and brought on by heat, electricity, chemicals, fire, or flames. In the United States, researchers have shown that race and other healthcare inequalities lead to increased burn injuries among African Americans but have yet to explore their lived experiences after sustaining these injuries. This phenomenological study explored perceptions and understanding of the manifestation of burn injuries of seven African American burn survivors. Participants were recruited in health services public waiting areas, community storefronts, mailers, and on Facebook. Data were collected via …


Design Of End Bent Piles For Downdrag, Tanna Frye Oct 2024

Design Of End Bent Piles For Downdrag, Tanna Frye

USF Tampa Graduate Theses and Dissertations

Embankments are commonly used for bridge approaches, with mechanically stabilized earth (MSE) walls being the preferred choice in Florida. However, the construction of embankments leads to the settlement of the underlying soil, regardless of soil type. When piles are driven before embankment construction, the initial settlement of the original soil creates relative movement between the pile and the surrounding soil, introducing frictional forces. When the existing soils move downward relative to the pile, a downward-oriented side shear known as downdrag is introduced. While downdrag is addressed in current codes and textbooks, it is often only briefly mentioned and primarily in …


Multiscale & Multiphysics Model Of Damage In Lithium-Ion Batteries, Edris Akbari Oct 2024

Multiscale & Multiphysics Model Of Damage In Lithium-Ion Batteries, Edris Akbari

LSU Doctoral Dissertations

The demand for safer and more reliable lithium-ion batteries (LIBs) in electric vehicles has increased significantly, especially in addressing mechanical failures like internal short circuits (ISCs), which can lead to thermal runaway. This research investigates the mechanical behavior and damage mechanisms in lithium-ion pouch cells through a multiscale and multiphysics approach, focusing on Lithium Nickel Manganese Cobalt Oxide (NMC) and Lithium Iron Phosphate (LFP) batteries.

The study involved quasi-static and dynamic mechanical tests, including indentation and high-speed penetration, to evaluate stress-strain responses and fracture behaviors. Anisotropic mechanical properties were measured for individual battery components (anode, cathode, separator, and shell) using …


Assessing The Impact Of Ai Assisted Software Development And User Experience Of A College Football Simulation Game: A Study Of Player And Industry Professional Perspectives, Augustus J. Scarlato Iii Oct 2024

Assessing The Impact Of Ai Assisted Software Development And User Experience Of A College Football Simulation Game: A Study Of Player And Industry Professional Perspectives, Augustus J. Scarlato Iii

USF Tampa Graduate Theses and Dissertations

This research examines the use of Artificial Intelligence (AI) in the design of video games, specifically the development of a college football simulation game. This study documents the creation of an alpha version college simulation game assisted by Open AI’s Chat GPT 4.0 API, to potentially improve game development, gameplay realism, and user interaction. The study then assesses how both student players and industry professionals perceive AI-enhanced gaming, emphasizing the usability, gameplay experience, and overall quality of the game using a Likert scale survey. The analysis also highlights differences in perceptions between students and industry professionals, with the latter group …


Relationship Between Enrollment, Retention, Alumni Giving, And Financial Health At Historically Black Colleges And Universities, Kenneth Mercury Oct 2024

Relationship Between Enrollment, Retention, Alumni Giving, And Financial Health At Historically Black Colleges And Universities, Kenneth Mercury

Walden Dissertations and Doctoral Studies

Decreasing financial health damages an organization’s reputation and economic viability to survive. Historically Black Colleges and Universities (HBCUs) leaders must strive to improve their financial health to protect their institution’s reputation and risk of closure. Grounded in strategic enrollment management theory, the purpose of this quantitative ex-post facto study was to examine the relationship between student enrollment, student retention, alumni giving, and financial health of HBCUs. The participants were 101 HBCUs collected from the National Center for Education Statistics and the Voluntary Support of Education databases, from 2020 to 2022. The results of the multiple linear regression analysis showed that …


Predicting Attendance At Southeastern U.S.A Musement Parks Using Accessibility- And Amenity-Based Models, James Andrew Mccall, Joe Weber Oct 2024

Predicting Attendance At Southeastern U.S.A Musement Parks Using Accessibility- And Amenity-Based Models, James Andrew Mccall, Joe Weber

The Geographical Bulletin

This research examines the extent to which traditional geographic concepts of proximity can explain attendance to amusement parks in the Southeastern United States. Accessibility models were calculated for nineteen parks using both miles and driving times as measures of distance from population centers. Results show only weak relationships between attendance and distance from population. To test whether other factors are more important predictors of attendance, regression analysis was carried out using variables describing amenities and characteristics of the parks. The results show that a high level of explanation for attendance to parks is provided by ticket price, parking cost, the …


Ten Challenges And Opportunities In Computational Immuno-Oncology, Riyue Bao, Alan Hutson, Anant Madabhushi, Vanessa D Jonsson, Spencer R Rosario, Elana J Fertig, Lyndsay Harris, Jennifer Altreuter, Qingrong Chen, James Dignam, Andrew J Gentles, Edgar Gonzalez-Kozlova, Sacha Gnjatic, Erika Kim, Mark Long, Martin Morgan, Eytan Ruppin, David Van Valen, Hong Zhang, Natalie Vokes, Daoud Meerzaman, Song Liu, Eliezer M Van Allen, Yi Xing Oct 2024

Ten Challenges And Opportunities In Computational Immuno-Oncology, Riyue Bao, Alan Hutson, Anant Madabhushi, Vanessa D Jonsson, Spencer R Rosario, Elana J Fertig, Lyndsay Harris, Jennifer Altreuter, Qingrong Chen, James Dignam, Andrew J Gentles, Edgar Gonzalez-Kozlova, Sacha Gnjatic, Erika Kim, Mark Long, Martin Morgan, Eytan Ruppin, David Van Valen, Hong Zhang, Natalie Vokes, Daoud Meerzaman, Song Liu, Eliezer M Van Allen, Yi Xing

Faculty, Staff and Student Publications

Immuno-oncology has transformed the treatment of cancer, with several immunotherapies becoming the standard treatment across histologies. Despite these advancements, the majority of patients do not experience durable clinical benefits, highlighting the imperative for ongoing advancement in immuno-oncology. Computational immuno-oncology emerges as a forefront discipline that draws on biomedical data science and intersects with oncology, immunology, and clinical research, with the overarching goal to accelerate the development of effective and safe immuno-oncology treatments from the laboratory to the clinic. In this review, we outline 10 critical challenges and opportunities in computational immuno-oncology, emphasizing the importance of robust computational strategies and interdisciplinary …