Development Of A Mediation Model Of Pain Cognition In Adult Patients With Sickle Cell Disease, Daniel M. Sop

Theses and Dissertations

Pain is a hallmark of Sickle Cell Disease (SCD), a genetic hemoglobinopathy characterized by chronic hemolytic anemia, vaso-occlusion, and organ damage. While acute vaso-occlusive crises (VOC) have been extensively studied, the mechanisms underlying chronic pain and its interplay with brain function remain unclear. This dissertation investigates the relationships between cerebral blood flow (CBF), fluid cognition, and pain sensitivity in adults with SCD, utilizing advanced imaging techniques and validated assessment tools.

Arterial spin labeling (ASL) and functional magnetic resonance imaging (fMRI) were employed to measure CBF and brain activity, respectively. Pain sensitivity was assessed using the Pain Sensitivity Questionnaire (PSQ), and …

Development, Synthesis And Characterization Of Advanced Low- Cobalt And High-Nickel Cathode Materials For Lithium-Ion Batteries, Arjun Patel

Theses and Dissertations

This dissertation focuses on the improvement of structural and electrochemical stability of active materials for lithium-ion batteries. It explores the modification strategies to mitigate the issues related to Ni-rich cathode materials, along with the continuous production of cathode precursors using a slug flow reactor to improve the quality of the product.

The First part of the dissertation examines the effect of substitution of cobalt with aluminum and iron on the electrochemical stability of Ni-rich lithium nickel cobalt manganese oxide (NCM) materials. This study investigates how Al and Fe doping work and how they impact the performance and stability of these …

Immersive Medical Practice And Clinical Training: Virtual And Mixed Reality In Pharmacy And Orthopedic Surgery, Silas Semprini De Toledo Contaifer

Theses and Dissertations

Extended‑reality (XR) technologies including virtual reality (VR) and mixed reality (MR) offer new ways to improve training and surgical precision. This thesis evaluates their educational and clinical impact through two complementary studies.

Specific Aim 1 compared an immersive 360° video VR module with conventional training for teaching USP < 797> sterile‑compounding skills to second‑year PharmD students (N = 36). VR trainees raised their knowledge from 6.14 ± 1.55 to 8.69 ± 1.07, yet the overall post‑test advantage versus control was not statistically significant (U = 71.50, p = 0.21). Item‑level McNemar testing showed significant VR‑exclusive gains on three critical questions (K5, K6, …

Food Waste Renaissance: From The Table, For The Table, Yasamin Shaikhi

Theses and Dissertations

What if waste could be seen as a valuable resource rather than a burden? Food Waste Renaissance (FWR) explores innovative ways to transform excess food and byproducts into sustainable design materials. In Qatar, where food waste constitutes approximately 60% of urban waste, FWR promotes a shift in perception rather than attempting to resolve large-scale waste management issues. By fostering a culture where surplus becomes a resource, it inspires individuals, designers, and communities to embrace and contribute to a circular economy. FWR examines rice and date byproducts as biodegradable raw materials for lamps, bringing material from the table back to the …

Civic Conservation Workshop: A User Manual For Creating A Makerspace Dedicated To Historic Preservation, Building Repair, And Civic Engagement, Madeleine Bean

Theses and Dissertations

Research Abstract:

Democracy depends on citizens’ participation at all levels, from local to national; moreover, engagement in one’s community is directly correlated with greater reported feelings of happiness and trust (Cox et al., 2021). This research examines how makerspaces can act as civic hubs that promote inclusive community interaction, facilitate the exchange of cultural and skills-based knowledge, encourage civic discourse, and serve as sites for political engagement through the provision of tools and resources that focus on historic home repair/preservation and craft-based trades. Specifically, this study proposes the development and design of a preservation-focused makerspace in Jackson Ward, a historically …

The Bacteriostatic, Regenerative, And Immunomodulatory Properties Of Extracellular Matrix Particles For Lung Injury, Keera P. Rhoads

Theses and Dissertations

Acute respiratory distress syndrome (ARDS) is a prevalent, life-threatening lung condition, affecting nearly 200,000 Americans annually, with a 40% international mortality rate. There is no cure for ARDS, and current pharmacological treatments have limited effectiveness. Symptoms can be mitigated with mechanical ventilation, though this often leads to ventilator-induced lung injuries (VILI) and puts critically ill patients at risk of infections, including ventilator-associated pneumonia (VAP). A promising therapeutic is the extracellular matrix (ECM), a complex network of structural proteins and bioactive molecules that has been shown to have anti-inflammatory properties and prevent fibrosis. We aim to utilize the regenerative and immunomodulatory …

Hafnium Oxide-Based Nanoheterostructures For Catalytic Radiosensitization And Enhanced X-Ray Radiotherapy, Marlen Dariela Calix Quezada

Theses and Dissertations

Orthovoltage X-ray beams are attractive for surface and intra-operative radiotherapy. Yet, their clinical utility is constrained by rapid attenuation and the limited dose that can be delivered without harming healthy tissue. High-Z hafnium oxide (HfO₂) nanoparticles can boost local energy deposition through the photoelectric effect, while catalytic surface defects accelerate water radiolysis. Harnessing both mechanisms in a single nano-heterostructure could enable potent radiosensitization at diagnostic-range energies.

This thesis develops and evaluates HfO₂-based nanoheterostructures, both bare and Au-decorated, as catalytic radiosensitizers.

Two types of HfO₂ were evaluated, one was synthesized following a specific route and the …

An Exploration Of The Relationship Between School Counselor Access And Latine Students’ College-Going Behaviors, Kristen Tuxbury

Theses and Dissertations

This study examined the relationships between school counselor access and Latine students’ college-going behaviors using data from the High School Longitudinal Study of 2009 (HSLS:09). The study was guided by critical race theory and Yosso’s community cultural wealth model (2005). Binary logistic regression models, Chi-square tests of independence, and descriptive statistics were used to explore the associations between school counselor access, Latine student college-going behaviors, and caregiver expectations. The findings show stronger associations between caregiver expectations and Latine student college-going behaviors than school counselor access. Additionally, findings provide evidence that experiences of oppression are likely barriers to Bachelor’s degree programs …

Dynamic Expression Of Transposable Elements Contributes To Molecular And Behavioral Adaptations To Cocaine, Gabriella M. Silva

Theses and Dissertations

The comorbidity of substance use disorder (SUDs) — specifically cocaine use disorder (CUD)— with anxiety and social deficit disorders complicates effective long-term treatment. More research is needed to understand the brain-region and cell type-specific mechanisms underlying these disorders to better address treatment gaps. This dissertation investigates the role of the transcription factor of interest ZFP189, a Krüppel-associated box (KRAB) zinc finger protein (ZFP), in governing pro-social behavior and the development of CUD across interconnected brain regions. We show that ZFP189 directly regulates transposable elements (TEs), repetitive DNA sequences capable of mobilizing and reinserting into the genome, which leads to subsequent …

Leveraging Distributed Semantics From Deep Learning Architectures For Literature-Based Discovery, Clint A. Cuffy

Theses and Dissertations

Literature-based discovery (LBD) is a scientific process that introduces methods to automatically identify novel insights between non-interacting sets of literature. To date, numerous statistical and machine learning-based methods have been applied in the biomedical domain to find treatments for diseases such as Raynaud's disease, Parkinson's disease, and Multiple Sclerosis. However, the lack of standardized practices and creation of bespoke methodologies produces a scenario where the adoption of LBD remains challenging in real-world systems. Our work addresses these concerns through the improvement of five critical areas: 1) error propagation within LBD's a priori dependent tasks, 2) exploring the integration of modern …

Rehabilitation In Stroke-Related Flexor Synergy, Shawn J. Dirocco

Theses and Dissertations

Upper extremity abnormal flexor synergy caused by stroke can impair individuals by coupling upper extremity muscles with deltoid activation. Previous studies have shown that reduction in deltoid loading can decrease flexor synergy. Robotic rehabilitation has the ability to allow for reduced deltoid loading while assisting or constraining joints along the arm to increase rehabilitation outcomes. The effects of higher degree of freedom low impedance robotics needs to be tested to learn how various parameters affect flexor synergy in comparison to end point robotics. During the first experiment, we tested 16 chronic stroke patients with flexor synergy problems in 3 tasks. …

The Impact Of Using Artificial Intelligence (Ai) On Employer Branding, Doaa Ayoub, Sherine Fathy El-Fekey, Malak Walid

Business Administration

Artificial Intelligence (AI) is revolutionizing Human Resource Management, enhancing efficiency, accuracy, and strategic capabilities as companies want to stay competitive in the global market. In recent years, AI has transformed numerous facets of business operations, especially in the development of employers’ branding strategies. Additionally, one-third (36%) of HR professionals anticipate a high use of AI in the next two years, while 61% expect at least moderate use within a year. AI enhances employers’ branding - fostering a work culture that attracts and retains top talent in the global market. Furthermore, the contribution of AI in improving employers’ branding strategies has …

Comparative Study Of Single Imputation Techniques For The Prediction Of Missing Dairy Data, Ahmed M. Gad Prof, Ahmed Abdelhakim Ahmed Mr, Eman Manaa Prof, Basant Shafik Dr, Sakr Mostafa Prof

Business Administration

Dairy farm records are a crucial component of effective livestock business management. Record analysis allows a farm’s owner to make informed decisions. Incomplete records are less useful for data analysis, so it's important to handle missing values correctly. This study compares different imputation methods for handling missing values in a dataset of dairy records comprising 997 records collected from 234 cows between 2012 and 2022. The dataset was screened against records with missing values and then deleted, resulting in 858 observations from 200 animals. There were missing values in two variables, with a missing percentage of 13.9%: days in milk …

Towards Understanding Thermal Management In Unsteady Boundary Layer Flow With Ac/Dc Electric Fields, Sara Abdelsalam, M. A. Dagher, Y. A. Elmaboud, A. I. Abdellateef

Basic Science Engineering

Unsteady boundary layer flow induced by alternating current (AC) or direct current (DC) electric field through a porous layer is investigated numerically. The finite difference method based on Crank-Nicolson is applied to solve the nonlinear system. The governing equations are built with fractional shear stress and the Cattaneo heat flux model, and time fractional derivatives are computed using the Caputo fractional derivative. The numerical results are presented to demonstrate the effects of varying parameters on momentum and thermal boundary layer. The results reveal that the time delay in the velocity profile occurs for larger values of both the velocity fractional …

Semi Analytical Solution Ofmhd And Heat Transfer Of Couple Stress Fluid Over A Stretching Sheet With Radiation In Porousmedium, Sara Abdelsalam, M. Khairy, W. Abbas, A.M. Megahed, M.S. Emam

Basic Science Engineering

This comprehensive research examines the dynamics of magnetohydrodynamic (MHD) flow and heat transfer within a couple stress fluid. The investigation specifically focuses on the fluid’s behavior over a vertical stretching sheet embedded within a porous medium, providing valuable insights into the complex interactions between fluid mechanics, thermal transport, and magnetic fields. This study accounts for the significant impact of heat generation and thermal radiation, crucial factors for enhancing heat transfer efficiency in various industrial and technological contexts. The research employs mathematical techniques to simplify complex partial differential equations (PDEs) governing fluid flow and heat transfer. Specifically, suitable similarity transformations are …

A Finite Difference Analysis Of Electroosmotic Flow Of A Two-Layer Jeffrey Fluid In A Vertical Porous Nanochannel, Y. Abdelmaboud, M. A. Elkot, Sara Abdelsalam

Basic Science Engineering

In this paper, we discuss the unsteady two-layer electroosmotic flow (EOF) of the Jeffrey fluid in a vertical porous nanochannel, taking into account the effect of the heat transfer and alternating current (AC) electric fields. In this model, the two layers have different densities and viscosities. The finite difference method is used to solve the governing equations of electrical potential, velocity, and temperature. The results show that the Debye-Hückel parameter is significant in managing electroosmotic flow (EOF) because it affects the electrical double layer (EDL) compression and velocity gradients on the wall. The higher the radiation parameter, the lower the …

Numerical Simulation Via Homotopy Perturbation Approach Of A Dissipative Squeezed Carreau Fluid Flow Due To A Sensor Surface, Sara Abdelsalam, W. Abbas, A.M. Megahed, H. M.H. Sadek, M.S. Emam

Basic Science Engineering

This study rigorously examines the interplay between viscous dissipation, magnetic effects, and thermal radiation on the flow behavior of a non-Newtonian Carreau squeezed fluid passing by a sensor surface within a micro cantilever channel, aiming to deepen our understanding of heat transport processes in complex fluid dynamics scenarios. The primary objective is to elucidate how physical operational parameters influence both the velocity of fluid flow and its temperature distribution, utilizing a comprehensive numerical approach. Employing a combination of mathematical modeling techniques, including similarity transformation, this investigation transforms complex partial differential equations into more manageable ordinary ones, subsequently solving them using …

Integrating Medical Plastic Waste Pyrolysis And Circular Economy For Environmental Sustainability, Attia Attia, Mohamed Bassyouni Prof., Reem Nasser Eng., Moataz El-Bagoury Eng., Islam Shaker Eng., Yasser Elhenawy Prof., Dina Aboelela Dr.

Biochemical Engineering

A critical assessment of pyrolysis technologies and reactor designs was discussed, highlighting various reactor configurations. This study explored the influence of catalysts, temperature, heating rate, and residence time on the pyrolysis process, and addressed their effects on product distribution and composition. Safety considerations and strategies for mitigating the potential environmental impacts of pyrolysis were presented. Comparative analyses of the environmental impacts of traditional waste disposal methods versus pyrolysis-based approaches provided insights into the potential reduction of greenhouse gas emissions and other pollutants. The circular economy approach was explored in the context of medical plastic waste pyrolysis. The potential for closing …

The Work And Lives Of Agricultural Workers, Cynthia Caron

Sustainability and Social Justice

In 2022, the World Bank estimated that roughly 27% of Sri Lankans worked in the agriculture sector. This chapter focuses on the lives of agricultural workers who cultivate their own farms or work as temporary labourers. It provides an overview of the factors that influence their agricultural livelihoods including but not limited to the structure of the country's agricultural economy and wages. The chapter discusses the risks and uncertainties that climate change, government policies, and agrochemical use present to workers and how they adapt. The chapter's final focus is the incorporation of workers including women into commercial agriculture and export-oriented …

The Cell-Fate Decision Of Dental Follicle Stem Cells (Dfscs) With Porcine Corneal Extracellular Matrix (Ecm), Chung-Hsing Li, Kuan-Ming Lin, Yong-Ren Chen, Ming-Hua Ho

Journal of Dental Sciences

Abstract Background/purpose Extracellular matrix (ECM) may be useful as a natural scaffold for tissue engineering. Since dental follicle stem cells (DFSCs) share a similar embryonic origin with corneal keratocytes and endothelial cells and possess the ability to proliferate and differentiate, in this study, we investigate the potential of DFSCs to differentiate into corneal cells under the supercritical carbon dioxide (SC–CO2) decellularized porcine corneal ECM culture stimulation. Materials and methods DFSCs were seeded onto the SC-CO2 decellularized porcine corneal ECM and the surrounding culture dish for 21 days. Cell morphology, reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and immunofluorescence staining were used …

Al Assisted Inventing And Its Impact On The Patent System, Ben Gross

Cardozo Arts & Entertainment Law Journal

The note examines the challenges posed by AI-assisted inventing to the patent system, particularly focusing on the "black box" nature of AI, which obscures the inventive process and complicates patent requirements such as inventorship and disclosure.

Antitrust And Console Gaming: Preventing Macrocompanies With Microtransactions, Cameron Brody

Cardozo Arts & Entertainment Law Journal

The note examines antitrust concerns in the console gaming industry, focusing on corporate consolidation and the impact of microtransactions. It argues that traditional antitrust strategies, such as foreclosure arguments, have proven ineffective in addressing these issues. The analysis suggests that microtransactions, particularly their role in exploiting consumers and consolidating market power, should be a focal point for new antitrust enforcement strategies. Regulators are urged to consider the broader implications of microtransactions on market structure and consumer welfare to develop innovative approaches to antitrust law.

Spotify's Dj Algo: An Analysis Of Copyright Infringement Risks In A.I.- Powered Music Curation, Eddie Halwani

Cardozo Arts & Entertainment Law Journal

The note examines the legal and policy implications of Spotify's AI-powered music curation, arguing that while its use of copyrighted material may constitute copyright infringement, it qualifies as fair use under the transformative and non-expressive purposes doctrine. However, the analysis highlights the need for economic reforms to ensure equitable compensation for rights holders and sustainable innovation.

Extending Revised Lewis Gear Root Bending Stress Model To Addendum Modified Cylindrical Gears, Edward E. Osakue

Faculty Publications

This paper presents a new revised Lewis gear bending root stress model for both standard profile and profile-shifted cylindrical gears. The three parameters that are used to extend the root bending stress capacity of standard profile gears to profile-shifted gears are the profile shift radius factor, the profile shift load factor, and the modified Lewis stress factor. These three parameters are functions of the profile shift factor. The new bending capacity model is used to estimate the bending stresses for some standard profile gears with nominal helix angles between 0o to 41.41o and compared with estimates of AGMA model. The …

A Bevel Gear Root Bending Stress Model, Edward E. Osakue, Rasoul Saneifard

Faculty Publications

A reversed Lewis root bending stress capacity model for bevel gears is presented. The model is developed from first principle based on the Tredgold’s approximation of a bevel gear. The approximation conceptually transforms a bevel gear into a spur gear. The load distribution of the bevel gear facewidth is assumed to be triangular so that the stress at the gear is constant over the facewidth. Six design cases of root bending stress computations from different references are done using the new and AGMA models. The stress estimates from the new and AGMA models were compared. The stress deviations associated with …

Evaluating The Implementation Of Social Determinants Of Health Screening In An Interdisciplinary Clinic, Taylor M. Adams

DNP Projects

Background: Social Determinants of Health (SDOH), including food, housing, interpersonal violence, and transportation are non-medical problems that can influence health outcomes (World Health Organization, 2020). Low-income minorities and public-payer groups are at considerable higher risk for social needs. Collaboration within the community can improve health outcomes (Sulley et al., 2021). A literature review revealed limited evidence of screening in dental clinic settings. Failure to identify and address SDOH needs in this population can lead to poorer health outcomes.

Purpose: The purpose of this quality improvement project was to implement and evaluate social determinants of health screening and evaluate the …

Evaluating The Outcomes Of An Educational Intervention For Providers And Two-Week Home Blood Pressure Monitoring In Adults, Michelle Ann Schuler

DNP Projects

Abstract

Background: Approximately 1.28 billion adults worldwide have hypertension (HTN), which greatly increases the risk of morbidity and premature death. Home blood pressure monitoring (HBPM) has been shown to increase efficacy of treatment decisions, but is underused in primary care. About 46% of adults are unaware that they have hypertension and only about 21% of those who have been diagnosed have it controlled.

Purpose: The purpose of this project is to evaluate a previous practice improvement project and improve the HBPM process for sustainability.

Methods This HBPM study utilized a retrospective study design combined with a practice improvement project …

Transit-Oriented Development On Aquidneck Island: Considering The Costs And Benefits Of Restoring Passenger Rail Between Fall River, Massachusetts, And Newport, Rhode Island, Maeve M. Newton

Pell Scholars and Senior Theses

This thesis considers the costs and benefits of restoring historic infrastructure as transit-oriented development on Aquidneck Island, and its potential to bridge social and economic gaps between the urban communities of Newport, Rhode Island, and Fall River, Massachusetts. There is a direct need for more robust public transportation on Aquidneck Island along with environmentally friendly planning initiatives, and reinstating the Newport Secondary Rail Line for passenger rail service to the new Fall River MBTA station is one important way for historic preservation to be utilized for the improvement of sustainability and socioeconomic equity in the region. Original research will be …

Zoysiagrass Tolerance To Selective Herbicides For The Removal Of Bermudagrass And The Distribution Of The Annual Bluegrass Weevil (Listronotus Maculicollis) In Kentucky, Kenneth D. Clayton

Theses and Dissertations--Plant and Soil Sciences

Bermudagrass (Cynodon dactylon) may be a problematic weed within zoysiagrass (Zoysia spp.) swards across its entire range. The objective of this study was to determine the efficacy of the herbicide safener metcamifen + trifloxysulfuron-sodium, in conjunction with fluazifop-P-butyl, at removing bermudagrass from zoysiagrass and how varying levels of treatment affected bermudagrass control and zoysiagrass tolerance. Field studies tested rates of metcamifen + trifloxysulfuron-sodium applied with fluazifop-P-butyl compared to treatments of fluazifop alone and fenoxaprop with triclopyr. All treatments controlled bermudagrass, and treatments with the herbicide safener remained under the 20% injury threshold for zoysiagrass for ≤ to 15 days compared …

Giving Props To Soil Property Predictive Models: Utilizing Mir To Predict Soil Health Properties, Diala M. Abboud

Theses and Dissertations--Plant and Soil Sciences

Soil health is critical to sustaining life on Earth, influencing plant growth, agricultural productivity, water quality, and overall ecosystem sustainability. In response to climate change and intensifying land use, the need to improve our understanding of soil health has become increasingly urgent. The application of mid-infrared (MIR) spectroscopy coupled with statistical modeling has emerged as a promising, cost-effective approach to predict soil health parameters, offering a quicker alternative to traditional wet chemistry analyses. MIR methods have been successfully applied to predict various soil health properties, such as bulk density (BD), cation exchange capacity (CEC), base saturation (BS), electrical conductivity (EC), …