Digital Commons Network^™

Integrative Computational Modeling Of Distinct Binding Mechanisms For Broadly Neutralizing Antibodies Targeting Sars-Cov-2 Spike Omicron Variants: Balance Of Evolutionary And Dynamic Adaptability In Shaping Molecular Determinants Of Immune Escape, Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

In this study, we conducted a comprehensive analysis of the interactions between the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein and four neutralizing antibodies—S309, S304, CYFN1006, and VIR-7229. Using integrative computational modeling that combined all-atom molecular dynamics (MD) simulations, mutational scanning, and MM-GBSA binding free energy calculations, we elucidated the structural, energetic, and dynamic determinants of antibody binding. Our findings reveal distinct dynamic binding mechanisms and evolutionary adaptation driving the broad neutralization effect of these antibodies. We show that S309 targets conserved residues near the ACE2 interface, leveraging synergistic van der Waals and electrostatic interactions, while S304 focuses on …

Customer Attractiveness In Public Procurement - One Size Does Not Fit All, Kati Loijas, Aki Jaaskelainen, Elina Karttunen, Frederik G. S. Vos

Business Faculty Publications and Presentations

Purpose:

The purpose of this study is to provide new insights into the differences between the attractiveness drivers in different types of public procurement (i.e. efficient, technological, adapted and experimental). Design/methodology/approach This study used a qualitative multiple-case study design. The study examined eight public procurement cases by interviewing the representatives of 18 suppliers and, through cross-case analysis, formulated a framework of customer attractiveness drivers for different types of public procurement. Findings This study reveals differences in customer attractiveness drivers between efficient, technological, adapted and experimental public procurement. This study finds that economic and market growth drivers are only sufficient for …

Current Paradigm And Futuristic Vision On New-Onset Diabetes And Pancreatic Cancer Research, Russell Moreland Iii, Abigail Arredondo, Anupam Dhasmana, Swati Dhasmana, Shabia Shabir, Asfia Siddiqua, Bonny Bannerjee, Murali Yallapu, Stephen Behrman, Subhash Chauhan, Sheema Khan

School of Medicine Publications

New-onset diabetes (NOD) has emerged as a potential early indicator of pancreatic cancer (PC), necessitating a refined clinical approach for risk assessment and early detection. This study discusses critical gaps in understanding the NOD-PC relationship and proposes a multifaceted approach to enhance early detection and risk assessment. We present a comprehensive clinical workflow for evaluating NOD patients, incorporating biomarker discovery, genetic screening, and AI-driven imaging to improve PC risk stratification. While existing models consider metabolic factors, they often overlook germline genetic predispositions that may influence disease development. We propose integrating germline genetic testing to identify individuals carrying pathogenic variants in …

Stomatal Distribution And Post-Fire Recovery: Intra-And Interspecific Variation In Plants Of The Pyrogenic Florida Scrub, Genevieve Triplett, Aaron S. David

Faculty Publications

Premise

Amphistomy, the presence of stomata on both leaf surfaces, can increase photosynthesis yet is uncommon across vascular plants. The relative infrequency of amphistomy is often attributed to high costs, such as transpirational water loss. The Florida scrub—a hot, dry, shrub-dominated habitat—historically has experienced frequent fire, yet decades of anthropogenic suppression coupled with the reintroduction of prescribed burns has led to varied fire regimes. In this study, we investigated the links between amphistomy and fire with regard to the presence of the trait across species in this pyrogenic habitat and within-species variation before and after experimental fire and across a …

The Tax Adviser, Volume 14, Number 5, May 1983, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.

Professional Corporations And The Affiliated Service Group, Stephen M. Howard

Tax Adviser

No abstract provided.

How Atlanta's Use Of Eminent Domain Displace Low-Income Peoplestown Residents, Babafemi Fatade

Tennessee Journal of Race, Gender, & Social Justice

No abstract provided.

Tennessee Journal Of Race, Gender, And Social Justice Vol. 14, Iss.2 (Full Publication), Editor In Chief

Tennessee Journal of Race, Gender, & Social Justice

No abstract provided.

Polyrelativity, Frederic Gilles Sourgens

Pepperdine Law Review

Energy transition has a governance problem. And much of the literature fails to address this problem. That is, it discusses who should make energy transition decisions (the President, Congress, state governments, etc.). But this perspective misses the core substantive problem: how should we share the benefits and burdens of transition? Without answering this energy transition “how” question, any answer to “who” risks appearing as arbitrary decision-making. In this Article, I am the first to submit that we can solve this “how” question using the property-law doctrine of correlative rights. Energy-transition governance is what political economists call “polycentric.” It requires different …

Washington Report: Aicpa Comments On Modified Proposed Circular 230 Regulations, Kenneth F. Thomas, William R. Stromsem

Tax Adviser

No abstract provided.

Tax Contingency Audit Workpapers: 1981-1982 Developments, Observations And Proposals, William T. Diss, Robert E. Hanson

Tax Adviser

No abstract provided.

Analysis Of Heavy Metal Pollution In E-Waste Dumpsites From Two Local Government Areas In Ogun State, South Western Nigeria, Adetoro T. Talabi, Timothy W. David, Abayomi E. Ajetunmobi, Rasaki K. Odunaike, Shamsideen K. Alausa

Sultan Qaboos University Journal For Science

Dumping sites in general have been noted to be sources of pollution in the environment and e-waste dumping sites are not exempted. A study on the pollution of heavy metals in two local government areas (LGAs) in Ogun State, was investigated. As, Cd, Co, Cr, Cu, Fe, Ni, Pb, and Zn were detected. Cd, Cu were detected in two areas. While Fe, Pb in four areas, and Zn concentrations were above the World Health Organisation permissible limit. Analysis indicates that the contaminant factor (CF) varies from low to severe at both LGAs; however, CF of Cd is severe in all …

Intuitive Gesture-Based Intent Specification For Search Workflows, Gulmohar Khan, Ramprasad Sedouram

Defensive Publications Series

Many search applications support multimodal search where results in different modalities are delivered. In some contexts, search results may also include AI-generated content that is responsive to a user query. However, current user interfaces for search do not enable a user to easily specify their intent, e.g., web results vs. generative results; text-only, image-only, video-only results, etc. This disclosure describes an intuitive, gesture-based user interface that enables users to specify their search intent when initiating a search. The gesture may be performed with reference to a user interface element such as a call-to-action button, a virtual keyboard, a dropdown menu, …

Vision Ai-Enabled External Monitor Brightness Adjustment, Hp Inc

Defensive Publications Series

Modern computing environments increasingly incorporate multiple external monitors, enhancing productivity and workflow. However, adjusting monitor brightness remains cumbersome due to inconvenient physical buttons and inconsistent software settings across different devices. This invention introduces an intelligent brightness control system, utilizing Vision AI technology and software, allowing users to adjust external display brightness simply by looking at the monitor and pressing a hot key on their laptop keyboard.

Enabling Calibration Of A Second Monitor From A Calibrated Primary Monitor, Hp Inc

Defensive Publications Series

This disclosure relates to the field of computer displays (monitors) with application of Video & Color components to better meet Color Critical User needs.

Monitors can be designed to either be Color Calibrated or not, depending on the User needs for color accuracy in their field of work.

In order to be color calibrated, a specialized color pipeline needs to be part of the overall monitor design, in order to correct for the imperfections of the Panel or of any of its components (color filters, LEDs, materials, Quantum dots, etc.) used.

Color calibrated high performance displays are usually full-featured premium …

An Innovative Constraint-Induced Movement Therapy (Cimt) Program Design And Case Study To Address Upper Extremity Use And Spatial Inattention, Mark Blanchard, Ingrid A. Franc, Payton Nisby, Michelle Arceneaux, Kathleen Chapiesky, Genevieve Ducros, Austin Brannon

Journal of Interprofessional Practice and Collaboration

Introduction: Common consequences of stroke include decreased upper extremity function and spatial inattention, both of which cause difficulties in occupational performance in activities of daily living. Constraint-Induced Movement Therapy (CIMT) is an intervention that has been utilized to improve these consequences of stroke.

Methods: This single case study describes the design and results of a two-week modified CIMT (mCIMT) program that used an enhanced visual and auditory feedback system, the Flint Rehab FitMi device, to address both upper extremity function and left spatial inattention in one participant. Left spatial awareness was encouraged during mCIMT activities by striking targeted pucks placed …

External Data Retrieval: The Effect Of Prompt Techniques And Inference Parameters On Llms Performance, Hp Inc

Defensive Publications Series

In this work, we explore the development of a software application using Large Language Models (LLMs) to retrieve data from public GitHub repositories. The reliance on external sources can increase susceptibility to failures due to various factors, which are discussed in the following sections of this paper. Decoding strategies and prompt engineering are addressed to improve the coherence of LLM responses. We conducted experiments demonstrating how prompt techniques and inference parameters, such as temperature and top-p, affect model accuracy. The goal is to develop an application that extracts data from GitHub and generates outputs in natural language, enhancing user comprehension. …

Inkjet Printed 3d Magnetic And Dielectric Polymer Composites With Tailored Properties, Hp Inc

Defensive Publications Series

The use of multi jet fusion (MJF) 3D-printing technology with magnetic nanoparticle inks and a novel pore-producing ink together with voxel-scale engineering techniques and predictive modeling provides an approach for designing and printing novel polymer nanocomposites and metamaterials with tailored physical and functional properties.

Reassessing Policy Responses To Irregular Migration In Receiving Democracies: A Process-Tracing Analysis Of Transactional Migration Governance, Otoniel Ramos

Student Research

This policy brief analyzes the growing use of transactional migration agreements (TMAs) by receiving democracies—bilateral arrangements that exchange financial or diplomatic concessions for the external enforcement of migration control. While politically expedient, TMAs often generate long-term strategic liabilities: they reduce state control over enforcement outcomes, expose receiving states to coercive leverage by partner states, and weaken normative commitments to transparency and rights protection. Using analytic process tracing and formal modeling, this paper identifies four recurring mechanisms by which TMAs evolve into systems of asymmetric dependence. It then evaluates three alternative policy frameworks—Exit Doctrine, Legal Category Reform, and a Structured Conditionality …

Commencement: Conferral Of Baccalaureate Degrees May 21, 2025, New Jersey Institute Of Technology

Commencement Programs

Program for the commencement conferral of Baccalaureate degrees. The ceremony took place on Wednesday, May 21, 2025.

Influence Of Acid-Catalyzed Dehydration And Pressure On Woody Biomass Carbonization: Exploring Carbon Yield, Heteroatom Functionalities, And Biochar Atomistic Structure, Valentina Sierra, Robert J. Macias, Jonathan P. Mathews, Vincent Carré, Sébastien L Eclerc, Alice Budai, Farid Chejne, Jimena Castro-Gutierrez, Vanessa Fierro, Manuel Garcia-Perez

Bio-Char IV

Please click Additional Files below to see the full abstract

Biochar As A Multi-Tasking Agent In Agricultural Mulch Films: From End-Of- Life Management To Processing Additive, Yvan Hernandez, Harshal Kansara, Ibrahim Cisse, Thomas Trabold, Carlos Diaz Acosta

Bio-Char IV

Please click Additional Files below to see the full abstract

Biochar As Biofertilizer For The Cultivation Of Strawberries, Silvia Fiore, Ilaria Orlandella, Marco Piras, Elena Belcore, Kyra Nancie Smith, Franco Berruti

Bio-Char IV

Please click Additional Files below to see the full abstract

Leveraging Reduced Order Models And High-Fidelity Simulations For Efficient Multifidelity Uncertainty Quantification Of Thermal Systems, Jakob G. Bates

Theses and Dissertations

Simulation-led design is becoming an important part of thermal systems design. Simulations of thermal systems continue to improve in their fidelity, but this comes with an increased computational cost. Additionally, uncertainty in simulation inputs, such as thermophysical properties, leads to uncertainty in simulation outputs. For simulations to be used rigorously for simulation-led design, this uncertainty must be quantified. Performing uncertainty quantification on thermal simulations is made difficult by their many uncertain parameters and high computational cost. Multifidelity uncertainty quantification is a set of methods that reduce the cost of uncertainty quantification by leveraging high-fidelity, high-cost simulations with low-fidelity, low-cost simulations. …

The Future Of The Us Marine Seafloor And Subseafloor Sampling Capabilities, Future 2024 Pi-Team, Olga Libman‐Roshal

Department of Earth and Environmental Studies Faculty Scholarship and Creative Works

Recent changes in US oceanographic assets are impacting scientists' ability to access seafloor and sub-seafloor materials and thus constraining progress on science critical for societal needs. Here we identify national infrastructure needs to address critical science questions. This commentary reports on community-driven discussions that took place during the 3-day FUTURE of US Seafloor Sampling Capabilities 2024 Workshop, which used an “all-hands-on-deck” approach to assess seafloor and sub-seafloor sampling requirements of a broad range of scientific objectives, focusing on capabilities that could be supported through the US Academic Research Fleet (US-ARF) now or in the near future. Cross-cutting issues identified …

Development Of Stem-Based Virtual Microscope Module In Fundamental Geology Course, Bigharta Bekti Susetyo, Dipo Caesario, Yulia Hanoselina, Helfia Edial, Intan Lestari Mulyaning Tyas, Ahmad Syauqi Hidayatillah, Alfyananda Kurnia Putra, Salem Amer Sayma

Jurnal Pendidikan Geografi: Kajian, Teori, dan Praktek dalam Bidang Pendidikan dan Ilmu Geografi

This research aims to develop a STEM-based virtual microscope module. It follows a 4D development model, comprising define, design, develop, and disseminate stages. Interview were employed as the primary data collection techniques. The data analysis techniques utilized both descriptive and quantitative methods. The feasibility of developed module validated by expert validators in material content, language, and learning design. Field testing was conducted with Geography Education Study Program students from Class of 2023 in the Fundamental Geology Course. The STEM-based virtual microscope module was deemed suitable for learning activities, receiving validation scores in the "good" category with minor revisions required. Student …

Analyzing Land Cover And Use In Bichi, Kano, Nigeria With Google Earth Data, Kabiru Abdullahi Abdulhamid, Adi Wibowo, Muhammad Junaid

Jurnal Pendidikan Geografi: Kajian, Teori, dan Praktek dalam Bidang Pendidikan dan Ilmu Geografi

The research investigates land cover and land use change trends in Bichi, Kano State, Nigeria, between 2003 and 2023, with a focus on the impacts of agricultural expansion and urbanization. Google Earth Pro's high-resolution satellite imagery was used to assess trends in agricultural land, forest cover, and settlement areas. The findings reveal a drastic reduction in agricultural land from 60 hectares in 2003 to 40 hectares in 2023 and the decline of forest cover from 30 hectares to 20 hectares. On the other hand, built-up settlement areas increased from 10 hectares to 40 hectares. All these processes have resulted in …

Exploring Models Of Reflective Practice To Aid The Understanding Of Pilgrimage Experience, Chris Hall

International Journal of Religious Tourism and Pilgrimage

This paper explores the use of models of reflective practice to aid reflection and sense making for a walking pilgrimage experience and analyses the challenges of using such a model in this context. The paper then examines whether Greenia’s definition of pilgrimage experience can be used as a model to aid reflection. This is subsequently applied to a 5-day walking pilgrimage experience and its effectiveness assessed.

Harnessing Eco-Friendly Practices And Transforming Communities Through Social Entrepreneurship: Exploring The Shri Mata Vaishno Devi Shrine Mode, Iqra Sajad Khan Scholar, Ashaq Hussain Najar Dr, Manik Arora Dr

International Journal of Religious Tourism and Pilgrimage

This study examines the influence of religious tourism on regional development, with a specific focus on eco-friendly practices and social entrepreneurship. Religious pilgrimages play a significant role in stimulating the tourism sector, hence, creating economic prospects on a global scale. Nevertheless, the extent of scholarly investigation about the impact of implementing eco-friendly practices on nearby communities, particularly within the context of religious pilgrimage destinations, remains minimal. The primary objective of this research centres on the Shri Mata Vaishno Devi shrine located in Jammu and Kashmir renowned for its widespread praise and profound cultural importance. A qualitative methodology was employed to …

School-Based Mental Health Practice: The Impact Of Physical Activity On Depression, Nafees Alam, Joy Krug

Social Work Faculty Publications

The relationship between physical and mental health has long been theorized to be profoundly important in understanding human behavior and development. This article aims specifically to highlight the state of existing research about the relationship between physical activity and the state of depression. Studies across the nation, summarized here, have found that healthy physical activity levels generally correlate with health within the mental and emotional arenas. Despite the abundance of existing literature on this topic, research remains scarce on the longitudinal effects of physical activity beginning with pre-puberty children into adulthood. Physical activity is a relatively cheap and non-harmful lifestyle …