Digital Commons Network^™

Biophysical Properties Of Trophoblast Placental Plasma Membrane, Nelly-Raissa Setchie-Tchato

Theses - ALL

The lack of experimental research on a woman’s placenta due to ethical restrictions has led to little to no research on the biophysical changes at the molecular level that a woman undergoes during pregnancy. This research aims to understand biophysical changes in placental trophoblast cells that facilitate diffusion between maternal and fetal blood during the first and third trimesters. It is challenging to comprehend the function of the placental trophoblast lipid membrane in regulating molecular transport between the mother and placental trophoblast cells due to inadequate in vitro models. For this reason, we utilized recent findings on the lipid compositions …

Discovering The Kinetic Behaviors Of Zeolites Of Mordenite, Ferrierite, Faujasite, Beta, Weixuan Huang

Theses - ALL

Fossil fuels have played a significant role in the development of nations. However, they have also given rise to various societal problems. In this context, Gamma-Valerolactone (GVL) emerges as a potential solution as a fuel additive and feedstock for the production of gasoline, jet fuel, and other products. GVL can undergo decarboxylation reactions facilitated by zeolite catalysts. Surprisingly, it has been observed that reactions taking place on different zeolites, despite having similar Brønsted acid site densities, exhibit distinct simulated initial rates. This research aims to compare the initial rate trends of mordenite and its poisoned derivatives with those of the …

Biophysical Properties Of Trophoblast Placental Plasma Membrane, Nelly-Raissa Setchie-Tchato

Theses - ALL

The lack of experimental research on a woman’s placenta due to ethical restrictions has led to little to no research on the biophysical changes at the molecular level that a woman undergoes during pregnancy. This research aims to understand biophysical changes in placental trophoblast cells that facilitate diffusion between maternal and fetal blood during the first and third trimesters. It is challenging to comprehend the function of the placental trophoblast lipid membrane in regulating molecular transport between the mother and placental trophoblast cells due to inadequate in vitro models. For this reason, we utilized recent findings on the lipid compositions …

Discovering The Kinetic Behaviors Of Zeolites Of Mordenite, Ferrierite, Faujasite, Beta, Weixuan Huang

Theses - ALL

Fossil fuels have played a significant role in the development of nations. However, they have also given rise to various societal problems. In this context, Gamma-Valerolactone (GVL) emerges as a potential solution as a fuel additive and feedstock for the production of gasoline, jet fuel, and other products. GVL can undergo decarboxylation reactions facilitated by zeolite catalysts. Surprisingly, it has been observed that reactions taking place on different zeolites, despite having similar Brønsted acid site densities, exhibit distinct simulated initial rates. This research aims to compare the initial rate trends of mordenite and its poisoned derivatives with those of the …

Revolutionising Health Care: Exploring The Latest Advances In Medical Sciences, Gehendra Mahara, Cuihong Tian, Xiaojia Xu, Wei Wang

Research outputs 2022 to 2026

Recent years have seen a revolution in the domain of medical science, with ground-breaking discoveries changing health care as we once knew it [1]. These advances have considerably improved disease diagnosis, treatment, and management, improving patient outcomes and quality of life [2–5]. . . .

Reduced Racial Disparity As A Result Of Survival Improvement In Prostate Cancer, Chao Cheng

Faculty, Staff and Students Publications

Prostate cancer is a cancer type associated with a high level of racial and socioeconomic disparities as reported by many previous studies. However, the changes in these disparities in the past two decades have not been systematically studied. In this study, we investigated the Surveillance Epidemiology End Results (SEER) data for prostate cancer patients diagnosed during 2004-2018. African Americans and Asians showed significantly better and worse cancer-specific survival (CSS), respectively, compared to non-Hispanic white individuals after adjusting for confounding factors such as age and cancer stage. Importantly, the data indicated that racial disparities fluctuated and reached the highest level during …

Framing, Emotions, Salience: The Future Of Ai As Seen By Redditors, Ayse Ocal

Dissertations - ALL

With today’s advanced technological improvements, the usage of various Artificial intelligence (AI) applications is still growing. This dissertation seeks to uncover how the future of AI is perceived by the social media users through the lens of technological frames and how these perceptions shape users’ emotions, attitudes, and the level of engagement stemming from salience of the frames. This shaping process is considered a type of social influence. The concept of technological frame is defined briefly as the interpretations, assumptions, expectations, and knowledge that people have about technology. Prior research suggests frames affect emotions and attitudes, and emotions and attitudes …

Shp2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors To Re-Treatment With Targeted Therapy, Shirish Gadgeel, Micaela B Reddy, Allison S Harney, Mohamed Elsayed, Adam W Cook, Christina E Wong, Ronald J Hinklin, Yutong Jiang, Eric N Brown, Nickolas A Neitzel, Ellen R Laird, Wen-I Wu, Anurag Singh, Ping Wei, Keith A Ching, John J Gaudino, Patrice A Lee, Dylan P Hartley

Faculty, Staff and Student Publications

Rationally targeted therapies have transformed cancer treatment, but many patients develop resistance through bypass signaling pathway activation. PF-07284892 (ARRY-558) is an allosteric SHP2 inhibitor designed to overcome bypass-signaling-mediated resistance when combined with inhibitors of various oncogenic drivers. Activity in this setting was confirmed in diverse tumor models. Patients with ALK fusion–positive lung cancer, BRAF^V600E-mutant colorectal cancer, KRAS^G12D-mutant ovarian cancer, and ROS1 fusion–positive pancreatic cancer who previously developed targeted therapy resistance were treated with PF-07284892 on the first dose level of a first-in-human clinical trial. After progression on PF-07284892 monotherapy, a novel study design allowed the addition …

Developing A New Three-Dimensional Finite-Difference Explicit In Time Solver Package For Modflow, Babak Azari

Electronic Theses and Dissertations Archive

Integrating existing surface water (SW) and groundwater (GW) models like SWAT, MODFLOW, and HEC-RAS has been explored to simulate the complexities of SW-GW interactions. Still, challenges arise from temporal and spatial scale disparities. To tackle the temporal scale issue, this study introduces the novel explicit solver (EXP1) for MODFLOW 2005, enabling daily GW modeling similar to SWAT and HEC-RAS by reducing runtime and computational burden. The proposed solver incorporates a stability criterion to assess the stability of the proposed solver. The study compared the EXP1 solver to the widely used Preconditioned Conjugate Gradient (PCG) solver in three scenarios: a 1D …

Discovery Of Gamma Rays From The Quiescent Sun With Hawc, A. Albert, R. Alfaro, C. Alvarez, J. C. Arteaga-Velázquez, D. Avila Rojas, H. A. Ayala Solares, R. Babu, E. Belmont-Moreno, C. Brisbois, K. S. Caballero-Mora, T. Capistrán, A. Carramiñana, S. Casanova, O. Chaparro-Amaro, U. Cotti, J. Cotzomi, S. Coutiño De León, E. De La Fuente, R. Diaz Hernandez, B. L. Dingus, M. A. Duvernois, M. Durocher, J. C. Diaz-Velez, R. W. Ellsworth, K. Engel, C. Espinoza, K. L. Fan, K. Fang, M. Fernandez Alonso, H. Fleischhack, N. Fraija, J. A. Garcia-Gonzalez, F. Garfias, M. M. Gonzalez, J. A. Goodman, J. P. Harding, S. Hernandez, J. Hinton, D. Huang, F. Hueyotl-Zahuantitla, P. Huntemeyer, A. Iriarte, V. Joshi, S. Kaufmann, J. Lee, J. T. Linnemann, A. L. Longinotti, G. Luis-Raya, K. Malone, O. Martinez, J. Martinez-Castro, J. A. Matthews, P. Miranda-Romagnoli, J. A. Morales-Soto, E. Moreno, M. Mostafa, A. Nayerhoda, L. Nellen, M. U. Nisa, R. Noriega-Papaqui, L. Olivera-Nieto, N. Omodei, Y. Perez Araujo, E. G. Perez-Perez, C. D. Rho, D. Rosa-Gonzalez, E. Ruiz-Velasco, H. Salazar, D. Salazar-Galeggos, A. Sandoval, M. Schneider, J. Serna-Franco, A. J. Smith, Y. Son, R. W. Springer, O. Tibolla, K. Tollefson, I. Torres, R. Torres-Escobedo, R. Turner, F. Urena-Mena, E. Varela, J. Villasenor, Xiaojie Wang, I. J. Watson, E. Willox, S. Yun-Carcamo, H. Zhou, C. De Leon

Physics Faculty Research & Creative Works

We report the first detection of a TeV γ-ray flux from the solar disk (6.3σ), based on 6.1 years of data from the High-Altitude Water Cherenkov (HAWC) observatory. The 0.5-2.6 TeV spectrum is well fit by a power law, dN/dE=A(E/1 TeV)-γ, with A=(1.6±0.3)x10-12 TeV-1 cm-2 s-1 and γ=3.62±0.14. The flux shows a strong indication of anticorrelation with solar activity. These results extend the bright, hard GeV emission from the disk observed with Fermi-LAT, seemingly due to hadronic Galactic cosmic rays showering on nuclei in the solar atmosphere. However, current theoretical models are unable to explain the details of how solar …

Conserved Temporal Processing Principles In Olfactory Systems, Doris Ling

McKelvey School of Engineering Graduate Student Theses & Dissertations

Olfaction is a primitive sensory modality used by animals to perform basic functions such as searching for food or mates. Olfactory cues are highly temporally dynamic and therefore time is an important encoding dimension in this sensory modality. How olfactory information is encoded by the temporal patterns of neural responses remains a fundamental question in the field of sensory neuroscience. Furthermore, it is not understood whether different organisms employ similar neural encoding principles. In this work, I investigated how neural activity is patterned over time in the primary olfactory system of the American bird locust (Schisctocerca americana). Previous studies have …

Translating Deep Learning Into Scientific Domains: Case Studies In Bioactivation, Quantum Chemistry, And Clinical Studies, Kathryn Sarullo

McKelvey School of Engineering Graduate Student Theses & Dissertations

Artificial intelligence has made substantial progress in resolving key issues in a variety of scientific and technical domains, particularly in cross-disciplinary sciences. Deep learning is becoming ubiquitous, particularly in biology, healthcare, and drug discovery. Deep learning techniques offer chances to advance science with the potential to significantly outperform state-of-the-art approaches in many scientific fields. There are, however, notable challenges. Each discipline in which deep learning could be applied has a unique manner of communicating concepts, which we describe as interpretability, critical for use in science, both in industry and academia. Interpretability can be defined as decisions made during visualization generation …

Neighborhood- And Finer-Scale Spatial Variations In Environmental Noise And Air Pollution, Maryssa Loehr

McKelvey School of Engineering Graduate Student Theses & Dissertations

The urban environment contains both air pollution and noise pollution from various sources. For noise pollution, sources include biogenic emissions such as insect chorus and anthropogenic emissions such as highway traffic and airplane flyovers. Numerous studies link exposure to noise with increased health risks through mechanisms such as disruption of sleep and introduction of external stress factors. It is not clear whether biogenic and anthropogenic noise have differential impacts. Ultrafine particulate matter (UFP) contribute to adverse health outcomes such as asthma, obstructive pulmonary disease, cardiovascular disease, and lung cancer. Ambient UFP is currently not regulated in the United States with …

Potential Of Mirnas In Plasma Extracellular Vesicle For The Stratification Of Prostate Cancer In A South African Population, Dada Oluwaseyi Temilola, Martha Wium, Juliano Paccez, Azola Samkele Salukazana, Hasan H. Otu, Giuseppina M. Carbone, Lisa Kaestner, Stefano Cacciatore, Luiz Fernando Zerbini

Department of Electrical and Computer Engineering: Faculty Publications

Prostate cancer (PCa) is the most common cause of cancer death among African men. The analysis of microRNAs (miRNAs) in plasma extracellular vesicles (EVs) can be utilized as a non-invasive tool for the diagnosis of PCa. In this study, we used small RNA sequencing to profile miRNAs cargo in plasma EVs from South African PCa patients. We evaluated the differential expression of miRNAs between low and high Gleason scores in the plasma EVs of South African patients and in the prostatic tissue from data available in the Cancer Genome Atlas (TCGA) Data Portal. We identified 7 miRNAs differently expressed in …

Technical Report: A Framework For Confusion Mitigation In Task-Oriented Interactions, Na Li, Robert J. Ross

Articles

Confusion is a mental state that can be triggered in task-oriented interactions and which can if left unattended lead to boredom, frustration, or disengagement from the task at hand. Since previous work has demonstrated that confusion can be detected in embodied situated interactions from visual and auditory cues, in this technique report, we propose appropriate interaction structures which should be used to mitigate confusion. We motivate and describe this dialogue mechanism through an information state-style policy with examples, and also outline the approach we are taking to integrate such a meta-conversational goal alongside core task-oriented considerations in modern data driven …

The At-Hook Is An Evolutionarily Conserved Auto-Regulatory Domain Of Swi/Snf Required For Cell Lineage Priming, Dhurjhoti Saha, Solomon Hailu, Arjan Hada, Junwoo Lee, Jie Luo, Yuan-Chi Lin, Jim Persinger, Abhinav Jain, Bin Liu, Yue Lu, Payel Sen, Blaine Bartholomew

Faculty, Staff and Student Publications

The SWI/SNF ATP-dependent chromatin remodeler is a master regulator of the epigenome, controlling pluripotency and differentiation. Towards the C-terminus of the catalytic subunit of SWI/SNF is a motif called the AT-hook that is evolutionary conserved. The AT-hook is present in many chromatin modifiers and generally thought to help anchor them to DNA. We observe however that the AT-hook regulates the intrinsic DNA-stimulated ATPase activity aside from promoting SWI/SNF recruitment to DNA or nucleosomes by increasing the reaction velocity a factor of 13 with no accompanying change in substrate affinity (K

An Ontology-Based Approach For Harmonization And Cross-Cohort Query Of Alzheimer’S Disease Data Resources, Paul E Schulz

Faculty, Staff and Student Publications

BACKGROUND: In the United States, the National Alzheimer's Coordinating Center (NACC) and the Alzheimer's Disease Neuroimaging Initiative (ADNI) are two major data sharing resources for Alzheimer's Disease (AD) research. NACC and ADNI strive to make their data more FAIR (findable, interoperable, accessible and reusable) for the broader research community. However, there is limited work harmonizing and supporting cross-cohort interoperability of the two resources.

METHOD: In this paper, we leverage an ontology-based approach to harmonize data elements in the two resources and develop a web-based query system to search patient cohorts across the two resources. We first mapped data elements across …

Spatial Transcriptomics Of Intraductal Papillary Mucinous Neoplasms Of The Pancreas Identifies Nkx6-2 As A Driver Of Gastric Differentiation And Indolent Biological Potential, Marta Sans, Yuki Makino, Jimin Min, Kimal I Rajapakshe, Michele Yip-Schneider, Mark W Hurd, Javier A Gomez, Fredrik I Thege, Johannes F Fahrmann, Robert A Wolff, Michael P Kim, Paola A Guerrero, Anirban Maitra

Faculty, Staff and Student Publications

Intraductal Papillary Mucinous Neoplasms (IPMNs) of the pancreas are bona fide precursor lesions of pancreatic ductal adenocarcinoma (PDAC). The most common subtype of IPMNs harbor a gastric foveolar-type epithelium, and these low-grade mucinous neoplasms are harbingers of IPMNs with high-grade dysplasia and cancer. The molecular underpinning of gastric differentiation in IPMNs is unknown, although identifying drivers of this indolent phenotype might enable opportunities for intercepting progression to high-grade IPMN and cancer. We conducted spatial transcriptomics on a cohort of IPMNs, followed by orthogonal and cross species validation studies, which established the transcription factor NKX6-2 as a key determinant of gastric …

Cost-Free Diagnosis Of High Side Switch By Means Of A Multifunctional Pin Of An Fpga Without Modifying The Pca Design, Hp Inc

Defensive Publications Series

The distribution of electric power in certain printing devices may be done through a Power and Mechatronics PCA by means of an electronic switch based on a P-MOS circuit. This document explains how to use an FPGA pin with a multifunctional configuration to allow the diagnosis of the high-side PMOS switch without the need of additional components or modification of the PCA design. The problem and consequences of the current design are commented as well as the solution proposed to mitigate possible harmful scenarios. Finally, the series of advantages that this proposal brings are listed.

Resilient Leadership: Bridging The Research Divide And 4th Industrial Revolution In Creating Sustainable Pathways For Strengthening Research, Shirlene Neerputh

Proceedings of the IATUL Conferences

Library services have strengthened in responding relevance towards new realities facing research-led universities in the 21st century. The dawn of the digital era ushers in new technologies, augmented realities, research practices and culture, announcing the birth of resilient leadership. How can Library Leaders respond to bridge the research divide and build the 4th industrial revolution (IR) in universities? Academic libraries re-aligned post COVID 19, to fulfil the mandates of the research-intensive university goals: Enhancing the student experience; Supporting learning and teaching; Enhancing research and innovation. In connecting possibilities of the research-led universities, academic library services have strengthened its digital services …

Correlation Between Altmetric Score And Citation: A Study Based On 1000 Highly Cited Cancer Scientific Outputs, Mohammad Ahmadian, Hossein Vakilimofard, Hamzeh Mazaherilaghab

Proceedings of the IATUL Conferences

Objective: In recent years, indicators based on social media have been introduced as a complementary and expeditious tool along with scientometric indicators to evaluate scientific outputs. The aim of this study was to comprehensively analyze the altmetric indices on 1000 titles of the most cited articles in the field of cancer, which is one of the most vital issues in the medical community and is the second leading cause of death after CVDs. Material and Methods: The present study was descriptive and performed using altmetric indices. Bibliographic information of the research sample was extracted from the Scopus citation database. Data …

From Scratch To Launch; Leveraging University Of Miami Libraries’ Research Information Management System To Cultivate University-Wide Partnerships And Support Faculty Research Dissemination And Impact, Kineret Ben Knaan, Elizabeth Gushee, Angela Clark

Proceedings of the IATUL Conferences

Since 2017, the University of Miami Libraries (UML) has engaged with key stakeholders and institutional leaders to adapt and build a centralized, sustainable Research Information Management System (RIMS) helping to curate, manage, and promote institutional research output. This paper details the development and rollout of Esploro by Ex Libris (locally branded Scholarship@Miami), the Institutional Repository (IR), and the RIM system for the University of Miami (UM). The UML Esploro Implementation team leveraged Esploro’s Artificial intelligence and Machine Learning features to train the system to automatically capture and fetch relevant scholarly outputs produced by researchers affiliated with UM. Further, we consider …

Marketing And Promotion Of Library & Information Services And Products In The Higher Education Institutions In Uae, Durai Murugan Mari Muthu, Zafar Khan

Proceedings of the IATUL Conferences

There are different marketing strategies available to promote the library resources, services, products, and facilities. Some of the strategy primarily applied in libraries includes community surveys, innovations, publicity and public relations, advertising, communication skills, staff training and innovation, networking and pricing. The study focuses on different types of promotional activities and strategies applied by the surveyed libraries to enhance the utilization of library resources and services. Furthermore, the study tries to understand the attitude of librarians towards strategies of library products and services in the higher education institution of UAE. The study is primarily descriptive in nature with survey type …

The Youtube Social Capital - Library Users Finding A Place And Space On Youtube, Lindall Adams

Proceedings of the IATUL Conferences

The library is a source of social capital. Several studies have examined how library spaces, services, and programs generate social capital. In this manner, the physical library became the third space, following the first and second spaces of home and work. However, during the global lockdown, the third space closed its doors and redirected its attention to social media platforms. While libraries have been engaged in Web 2.0 endeavours since the early 2000s, maintaining social network presence has not been an option. Libraries were given the opportunity to reengage with social media as a result of the pandemic, and new …

Conceptual Framework Of Information Retrieval System In The Field Of Gastroenterology And Hepatology, Masoud Mohammadi, Fatemeh Sheikhshoaei

Proceedings of the IATUL Conferences

Background and aims: Optimal information retrieval is one of the components of achieving evidence-based medicine. This study aimed to present the Conceptual framework of information retrieval system in the field of Gastroenterology and hepatology. Methods: Based on the previous two studies, the characteristics of the optimal information retrieval system from the perspective of gastroenterologists and hepatologists and the most important approaches and technologies used in the design of information retrieval systems in medical sciences have been used in designing the proposed conceptual framework. Results: The conceptual framework of the information retrieval system in the gastroenterology and hepatology was presented in …

The Effects Of Postural Education Or Corrective Exercise On The Craniovertebral Angle In Young Adults With Forward Head Posture: A Randomized Controlled Trial, David A. Titcomb, Bridget F. Melton, Theresa Miyashita, Helen W. Bland

International Journal of Exercise Science

International Journal of Exercise Science 16(1): 954-973, 2023. The purpose of this study was to compare the effects of three different intervention strategies, postural education (PE) and two corrective exercise programs (CEPs), on the craniovertebral angle (CVA) in young adults with forward head posture (FHP). A prospective four-arm parallel randomized controlled trial with repeated measures was performed. Seventy-nine healthy young adults (55 women, 24 men; mean age: 20.08 ± 2.19 years) with FHP were randomized into four groups: PE group, self-myofascial release + stretching group (SMRS), self-myofascial release + stretching + strengthening group (SMRSS), and a control group (CG). Participant …

Increasing Trunk Mass Evokes Lower Extremity Biomechanical Plasticity During Stair Descent, Alexis Nelson, Hailey Fong, Alex Carnall, Melissa J. Puppa, Derek Beeler, Cris Stickley, William M. Mihalko, Douglas W. Powell

International Journal of Exercise Science

International Journal of Exercise Science 16(1): 942-953, 2023. The purpose of this study was to investigate the influence of simulated changes in body mass on lower extremity joint work and relative joint contributions during stair descent. Ten healthy recreationally active college-age participants performed five stair descent trials in each of five loading conditions: no added load and with an additional 5%, 10%, 15% and 20% of their body weight. Three-dimensional ankle, knee and hip joint powers were calculated using a six degree-of-freedom model in Visual3D (C-Motion Inc., Germantown, MD, USA). Sagittal plane joint work was calculated as the joint power …

Evanescent - Issue 4

Evanescent

Evanescent: A Journal of Literary Medicine is the journal of the Eakins Writing Project, which also sponsors the Drs. Theresa and Charles Yeo Writing Prize. The Eakins Writing Project is supported by the Jefferson Center for Injury Research and Prevention, located in the Department of Surgery of Thomas Jefferson University, Philadelphia.

Contents:

• Editorial Statement
• Compassion & Empathy
• The Anonymity & Randomness of Violence
• Souls Shot Portrait Gallery #1
• Fear, Safety & Helplessness
• Loss of Control & Accountability
• Souls Shot Portrait Gallery #2
• Reflection & Call to Action
• Afterword
• Winners of the 2022 Drs. Theresa and Charles Yeo Writing Prize

Novel Epoxy-Based Biocidal Composite Material Filled With Polylactide-Capsulated Copper (I) Oxide Particles, Maxim Danilaev, Safaa.M.R.H. Hussein, Elena Bobina, Sergey Karandashov, Vladimir Kuklin, Mikhail Klabu-Kov, Hong Quan Le, Ekaterina Mironskaya, Galina Yakovleva, Olga Ilinskaya

Karbala International Journal of Modern Science

To maintain performance of polymer composite materials (PCM) in tropical climate, it is necessary and relevant to deal with biodegradation among other factors. Increasing strength and improvement of biodegradation resistance of polymer composites simultaneously is a critical practical challenge. State-of-the-art methods of polymer composites production do not provide a possibility to address both issues at the same time. In this study, it is the first time when a method to increase strength of ED-20 epoxy-based polymer composite and improve its biodegradation resistance simultaneously is applied. In this study, the authors applied for the first time polylactide-capsulated copper oxide particles to …

Volksdrogen: The Third Reich Powered By Methamphetamine, Madison Isenberg

Senior Projects

Leading up to and during the Second World War, the Nazified German Government wanted to perpetuate the belief that due to their exceptional strength spread through various forms of propaganda the “Aryan Race” was undefeatable. Unfortunately, this testament, and the propaganda that supported it, is still used by some to substantiate their claims that the Nazis devised the “master race”. The source of their strength has remained largely unresearched, so what was the factor that allowed the German home and war front to possess large amounts of energy to aid in their fight against the Allied forces? Initially, from whisperings …