Digital Commons Network^™

How Smoking Became A Moral Issue: A Complex Systems Perspective On Moralization, Matthew Vanaman

Dissertations, Theses, and Capstone Projects

When something is morally wrong, it is in the moral domain; when something becomes morally wrong, it is moralized. But how do we know when something is in the moral domain, and how can we tell whether something is becoming moralized? The empirical study of morality, or a given person’s judgment of what constitutes moral virtue or vice, has historically approached these questions through one of three theoretical perspectives: cognitivism, which argues that people primarily or mostly use effortful thought to judge right from wrong; emotivism, which sees these judgments as flowing from emotion; and dual-process models, which …

Avoiding Success: How Does Fear Of Success Impact Today's Workforce?, Bradley E. Gray

Dissertations, Theses, and Capstone Projects

Fear of success refers to the anxiety experienced by individuals as they come close to accomplishing a goal, ambivalent and even paralyzed over choosing to accept or avoid success. Success fearers are more likely to avoid success, choosing to forego their goal to avoid the assumed negative repercussions that will accompany the success (Canavan, 1989). Though interest in fear of success has waned since its introduction in the 1970’s, evidence of fear of success still exists today. However, original theories of fear of success cannot explain its impact on both men and women, and little is known about how it …

The Archival Impulse: English Family Record Keeping And Archives, Ca. 1450–1700, Maura Kenny

Dissertations, Theses, and Capstone Projects

England in the fifteenth through seventeenth centuries witnessed a proliferation of documents arising from a growth in literacy and an expansion of state administrative offices. Scholarship on the archival history of this period has grown recently but it has focused mainly on institutional and state archives. Very little has been written about family or personal archives and the uses made of them. Based on modern archival theory and extensive archival research, this dissertation seeks to fill this gap by addressing the creation of family records and archives as a whole, exploring early modern English families as a “community of records.” …

Posthuman Lessons For Writing And Well-Being: Reparative Practices, Anna A. Larsson

Dissertations, Theses, and Capstone Projects

The influence of post-humanist interdisciplinary theories on Writing Studies has displaced its conventional preoccupation with the cultivation and management of subjects via First-Year Writing (FYC), to productive but at times artificially divisive ends. This project aims at an inclusive, anti-racist first-year writing ecology through theories of networked consciousness and digital “making.” I reread and recuperate earlier variants of posthumanist writing theory and draw from feminist materialism and mindfulness studies to establish a vision of well-being that I call networked reparative practices. To bring the abstract into the tangible, an often-valued endeavor in a field historically defined by teaching, I introduce …

Out-Of-Distribution Generalization Of Deep Learning To Illuminate Dark Protein Functional Space, Tian Cai

Dissertations, Theses, and Capstone Projects

Dark protein illumination is a fundamental challenge in drug discovery where majority human proteins are understudied, i.e. with only known protein sequence but no known small molecule binder. It's a major road block to enable drug discovery paradigm shift from single-targeted which looks to identify a single target and design drug to regulate the single target to multi-targeted in a Systems Pharmacology perspective. Diseases such as Alzheimer's and Opioid-Use-Disorder plaguing millions of patients call for effective multi-targeted approach involving dark proteins. Using limited protein data to predict dark protein property requires deep learning systems with OOD generalization capacity. Out-of-Distribution (OOD) …

The Role Of Nuclear Quantum Effects In Supercooled Water And Amorphous Ice, Ali H. Eltareb

Dissertations, Theses, and Capstone Projects

Water is one of the most important substances on Earth and plays a fundamental role in numerous scientific and engineering applications. Interestingly, water behaves much differently than other liquids. For example, water shows an anomalous density maximum at 277 K, the solid phase (ice) is less denser than the liquid, and its thermodynamic response functions, such as the specific heat C_P and isothermal compressibility κ_T, also increase anomalously upon cooling. In the glassy state, water can exist in two different forms, low-density and high-density amorphous ice (LDA and HDA). While water has been scrutinized for many centuries, …

Construction And Performance Optimization Of Bioconjugated Nanosensors For Early Detection Of Breast Cancer And Pro-Inflammatory Diseases, Pooja Gaikwad

Dissertations, Theses, and Capstone Projects

In recent years, nanosensors have emerged as a tool with strong potential in medical diagnostics. Single-walled carbon nanotube (SWCNT) based optical nanosensors have notably garnered interest due to the unique characteristics of their near-infrared fluorescence emission, including tissue transparency, photostability, and various chiralities with discrete absorption and fluorescence emission bands. Additionally, the optoelectronic properties of SWCNT are sensitive to the surrounding environment, which makes them suitable for in vitro and in vivo biosensing. Single-stranded (ss) DNA-wrapped SWCNTs have been reported as optical nanosensors for cancers and metabolic diseases. Breast cancer and cardiovascular diseases are the most common causes of death …

Nursing Perspectives On Intimate Partner Violence Screening In The Emergency Department, Justin Cabrera

Dissertations, Theses, and Capstone Projects

Using descriptive and quality descriptive (QD) analysis, emergency department nurses from around the country completed a modified version of the Physician Readiness to Manage Intimate Partner Violence Survey (PREMIS) tool to gain insight on their attitudes, knowledge, and preparedness about working with patient survivors of intimate partner violence (IPV) regarding their willingness to and comfort in engaging in IPV screening practices. In total, 1,523 responses were received from emergency department nurses currently or formerly in practice.

Findings show that there was no correlation between emergency department nurses’ education and training on IPV and willingness and comfort with IPV screening with …

Quantifying Temperature-, Pressure-, And Nuclear Quantum Effects On Hydrophobic And Hydrophilic Water-Mediated Interactions, Justin T. Engstler

Dissertations, Theses, and Capstone Projects

Water-mediated interactions (WMIs) are responsible for diverse processes in aqueous solutions, including protein folding and nanoparticle aggregation. WMI may be affected by changes in temperature and pressure, and hence, they can alter chemical/physical processes that occur in aqueous environments. Traditionally, attention has been focused on hydrophobic interactions while, in comparison, the role of hydrophilic and hybrid (hydrophobic–hydrophilic) interactions have been mostly overlooked. Here, we study the role of T and P on the WMI between nanoscale (i) hydrophobic–hydrophobic, (ii) hydrophilic–hydrophilic, and (iii) hydrophilic–hydrophobic pairs of (hydroxylated/non-hydroxylated) graphene-based surfaces. We find that hydrophobic, hydrophilic, and hybrid interactions are all sensitive to …

Nonlinear Processes In Room Temperature Exciton-Polaritons, Prathmesh Deshmukh

Dissertations, Theses, and Capstone Projects

Strong light-matter coupling in solid state systems is an intriguing process that allows one to exploit the advantages of both light and matter. In this context, microcavities have become essential platforms for studying the strong coupling regime, where hybrid light-matter states known as exciton-polaritons form, leading to enhanced light matter interaction, modified material properties, and novel quantum phenomena. In this thesis, we explore the phenomenology of exciton-polaritons in strained TMD microcavities, 2D perovskites, fluorescent proteins and organic dyes encompassing thermalization, polariton lasing, and the observation of nonlinear effects.

Transition metal dichalcogenides (TMDs) have emerged as a remarkable class of two- …

Doc/U/Ment: Affinities In 20th And 21st-Century Documental Poetics, Katherine Payne

Dissertations, Theses, and Capstone Projects

This dissertation presents, analyzes, and builds on the existing literary genealogy of documental poetry. In 2020 Michael Leong proposed the term documental poetry to describe the turn toward source materials in 21^st-century North American poetry, seen in longform research-based poems that explicitly incorporate documentation and seek to intervene in cultural memory. Using Ludwig Wittgenstein’s concept of family resemblance, I argue that there are clear affinities between 21^st-century poets and their 20^th-century literary forerunners, also that an expansion of the scope of documental poetics is needed. The three nodes of connection I examine are works …

Theorizing Racial Democracy, Teófilo De Souza Carmo Reis

Dissertations, Theses, and Capstone Projects

The critical philosophy of race has shown recent growth, but it tends to focus too much on the United States. This leaves many race-related concepts and phenomena from other parts of the world underexplored. I help to fill this gap by exploring the idea of "racial democracy" in Brazil, which is a form of racial ignorance that is prevalent in that country. Specifically, I am interested in the epistemic aspects of this mechanism of creating and propagating racial ignorance.

To achieve this goal, I begin by introducing Charles Mills' concept of white ignorance and other influential works in social epistemology. …

Rotation Period Distributions And Light Curve Morphologies Of Low Mass Stars And Young Associations, Mark Popinchalk

Dissertations, Theses, and Capstone Projects

This dissertation is centered around the rotation periods of low-mass stars and association of young stars. Rotation periods are a link to the age of the star, as they lose angular momentum over time. To understand how this angular momentum evolves requires understanding the rotation period distributions of a range of stellar types and ages. Traditionally, M dwarf stars and young stars were challenging to describe due to their intrinsic faintness and dispersed sky positions respectively. I approached this subject from several directions.

Centrality Effects On Heavy-Flavor Quark Production And Invariant Yield In Phenix Proton–Gold Collisions At Center-Of-Mass Energy 200 Gev, And Assembly, Testing, Calibration, And Installation Of The Sphenix Hadronic Calorimeters, Daniel Richford

Dissertations, Theses, and Capstone Projects

Hadrons created in heavy-ion collisions interact with the open color-charge of the quark-gluon plasma through their constituent quarks. The medium imparts substantial modifications to heavy-flavor hadrons' momentum spectra. For collisions of small systems, the centrality of those collisions affects both the production of heavy-quarks and the medium modifications that the heavy-quarks experience. This analysis uses the PHENIX detector at the Relativistic Heavy Ion Collider, which collected data from proton--gold collisions in 2015, with a trigger to preference the collection of the five-percent most-central collisions. This analysis uses the distance-of-closest-approach of electron tracks to study semileptonic decays from charm and bottom …

Tunable Linear And Nonlinear Metasurfaces Based On Hybrid Gold-Graphene Plasmons, Matthew Feinstein

Dissertations, Theses, and Capstone Projects

Optical Metasurfaces are planar structures that are patterned with subwavelength structures and are very thin compared to the wavelength of light. Despite their thinness, these structured materials can strongly interact with incident light to effect the functionalities of conventional optical components, such as rotation of the polarization state, beam steering, lensing, spectral filtering, and holography, to name a few. Metasurfaces can also facilitate nonlinear optical effects, such as the mixing of beams at different frequencies to generate a beam at a new frequency.

The ability to alter the behavior of a metasurface during operation is highly desired for applications such …

Structural Basis Of Signal Transduction Within Environmental Sensing Pas Regulated Ser/Thr Kinases, Roksana Azad

Dissertations, Theses, and Capstone Projects

To sense environmental cues, nature has evolved molecular switches that are widely used across life. This process often relies on environmentally controlled PPIs (Protein-Protein Interactions) within a sensory domain that senses various stimuli and alters the functional activities of downstream effectors. This study focused on the superfamily of PAS (Per-ARNT-Sim) environmental sensory domains and their roles in regulating two Ser/Thr Kinases (STKs). PAS domains achieve their regulatory control by internally binding small molecule ligands/cofactors (e.g., O₂ binding to heme …

Improving Collagen-Mimetic Fibrils To Study Fibrillogenesis And Effects Of Disease-Causing Mutations On Fibrillogenesis, Faizunnahar Dewan

Dissertations, Theses, and Capstone Projects

Collagen, the most abundant protein in the human body, serves as the scaffold of connective tissue and has biomaterial applications to promote wound healing. The need to study collagen further stems from a disease perspective, as mutations in collagen lead to numerous connective tissue diseases. While collagen has been explored extensively at the triple helix level, much remains undiscovered regarding its function at the fibril level due to the lack of an effective collagen model system. Using tandemly repeating “sequence units” that contain sequences from native collagen, our lab has previously developed fibril-forming collagen-mimetic peptides (FCMPs), which provide tools to …

Development Of Chemical Probes For Two Pro-Metastatic Enzymes: Cysteine Cathepsins And Nek2 Kinase, Ashif I. Bhuiyan

Dissertations, Theses, and Capstone Projects

Proteases, specifically cysteine proteases, are crucial for the survival and growth of living organisms. They hydrolyze proteins and use different mechanisms to function. Cysteine proteases are classified into three types: papain, caspase, and picornaviridae. The papain class, with 11 cysteine cathepsins, regulates essential physiological functions, and abnormal expression is linked to various diseases. Our research aims to develop small molecules that inhibit cathepsins B and L to develop probes for functional proteomics.

The centrosome is critical for proper cell division and is regulated by multiple kinases, including Nek2. Nek2 is highly concentrated at the centrosome in vertebrates and plays a …

Settling Into Inequality: Resettled Afghans In The Washington Dc Metro Area, Harry Frey

Dissertations, Theses, and Capstone Projects

Since the Taliban returned to power in Afghanistan in August of 2021, nearly 90,000 Afghans who had fled their country have been resettled in the United States, constituting one of the largest groups of refugee arrivals in the U.S. in recent history. Working from a database I created from the administrative records of a non-profit refugee aid group, I use data and spatial analysis to examine the demographics of Afghans resettled in the DC metro area, the characteristics of the census tracts and counties in which they have been resettled, and their access to public transportation. I find that the …

Memory, Violence, And Detours: Strategies Of Resistance To Epidermal Invisibility Within The French Republic, Claudine E. David

Dissertations, Theses, and Capstone Projects

The subjection of black citizens in France and their invisibility in the (post)colonial space has been marked by segregation in peripheral urban zones, with a hardening of policing methods and controls based on racial appearanc. I argue that monumental representation in public space is not neutral but participates in the promotion of a specific ideology. I show thé ellipses in French patrimonial monumental glorification, including the appropriation of the memory of revolutionary heroes such as Louis Delgrès and Toussaint Louverture, concomitant with the occultation of many other black figures. I argue that representation matters, that France must repair this asymmetrical …

Between Two Messiahs: An Ethnography Of Settler-Colonizers In The West Bank, Amir Reicher

Dissertations, Theses, and Capstone Projects

This dissertation is a study of settler-colonialism. Based on fieldwork among Jewish settlers in the West Bank, it analyzes from an anthropological perspective how a settler-colonial process takes place. Officially, since the signing of the Oslo Accords, with few exceptions, Israel ceased to build new settlements in the West Bank. But, on the ground, from the 1990s onwards, the West Bank hinterland was scattered with over 150 illegal outposts, strategically constructed to appropriate as much land as possible. Often established on remote hilltops, the illegal outposts are the central tool today in appropriating Palestinian land, and the “outpost people” who …

The Relationship Between “Black Lives Matter” Movement Protests And Police Arrests In New York City, Chicago, And Los Angeles: An Empirical Analysis, Lukas Louwagie

Dissertations, Theses, and Capstone Projects

The summer of 2020 marked a boiling point of protest and frustration at long-criticized police behavior in the United States. The events that summer revealed the “Black Lives Matter” (BLM) movement as something that could not be ignored and was capable of drawing national support and attention across many dividing lines (Mitchell 2020). Today, it seems evident that the BLM movement has had a substantial impact on modern political discourse—yet its impact on police behavior and reform, the primary target of the movement, is murky. Police departments across the nation are pushing back against calls to defund and reform their …

Recursive Functional Learning In Nonfluent Aphasia, Gerald C. Imaezue

Dissertations, Theses, and Capstone Projects

People with nonfluent aphasia (PWNA) require feedback from an external agent as well self-feedback to facilitate performance of language production tasks. The extent to which PWNA can use self-feedback alone to improve their task performance is unknown. In addition, it is argued that self-feedback may reinforce or minimize performance errors over time. To test whether either is the case, we introduce an original learning mechanism, recursive functional learning, which uses self-feedback loops to optimize recursively multiple subsystems (cognitive and linguistic subsystems) that PWNA engage during task performance. We used this mechanism to underpin a novel automated procedure we developed, recursive …

Sonorous Movement: Cellistic Corporealities In Works By Helmut Lachenmann, Simon Steen-Andersen, And Johan Svensson, John Popham

Dissertations, Theses, and Capstone Projects

In Sonorous Movement: Cellistic Corporealities in Works by Lachenmann, Steen-Andersen, and Svensson, I analyze three compositions that foreground the cellist-body, its physical gestures, and instrumental interactions: Helmut Lachemann’s Pression für einen Cellisten (1969/2010), Simon Steen-Andersen’s Study for String Instrument #3 (2011), and Johan Svensson’s marionette for string instrument, electro-mechanical devices and lights (2018). These works center sound production and the performing body as sites of ontological and creative exploration. Their physical gestures serve multiple sensorial functions, heightening the visual and kinesthetic dimensions of a traditionally aurally oriented practice. For each work, I develop a corresponding analytical method based on …

Burnout And Depression In Teachers And Members Of Other Occupational Groups: A Systematic Review And Meta-Analyses On Potentially Overlapping Conditions, Gail Swingler

Dissertations, Theses, and Capstone Projects

Burnout has long been recognized as a workplace issue among teachers, and other occupational groups. Burnout has potentially been increasing during the Covid-19 pandemic. Researchers tend to regard burnout as a distinct syndrome comprising emotional exhaustion (EE), depersonalization (DP), and reduced personal accomplishment (rPA). Recent evidence suggests that burnout (as a tripartite syndrome) lacks discriminant validity vis-à-vis depression. The overlap between burnout and depression was examined through two meta-analytic studies.

The first study (K = 13) examined the relationship between burnout and depression in teachers with burnout assessed using the MBI. The findings indicated that exhaustion (EE), and depression …

Characterization And Modulation Of The Emergent Material Properties Of Biomolecular Condensates, Alfredo Vidal Ceballos

Dissertations, Theses, and Capstone Projects

The discovery of membraneless organelles has revolutionized the field of cell biology and our understanding of cell compartmentalization. These organelles lack a distinct phospholipid bilayer and interact with the cytoplasm mediated by a liquid-liquid interface. The emergent properties and characterization of these organelles are essential for decoding the mechanisms underlying their function and dysfunction. In this thesis, we focus on two reconstituted in-vitro model systems of protein condensates and advance current methodology in order to address these fundamental questions. The first model system examined is the neuronal granule protein Fragile X Mental Retardation Protein (FMRP), an RNA-binding protein, that aids …

Ways Of Silence And Other Absences In The Music Of George Crumb, Jean-Patrick Besingrand

Dissertations, Theses, and Capstone Projects

The music of American composer George Crumb (1929-2022) is undeniably singular in the musical landscape. His aesthetic is often characterized by his exploration of timbre, his graphic scores, his use of quotation, his theatricality, and his interest in unusual instruments. This study proposes to take a different approach to Crumb’s aesthetic through the spectrum of silences and other absences. The concept of silence will be broken down and reconstructed through the Japanese concept of ma (間) and of empty spaces. Multiple types of silences and absences will be considered throughout this dissertation, expanding thus the concept of silence not only …

Magnetically-Driven Therapeutic Agents Delivery System Using Iron Oxide Nanocages And Enhancement Of Exosome Secretion, A Potential Biological Drug Delivery Carrier, Min A Kang

Dissertations, Theses, and Capstone Projects

Nano-scale particles have attracted research attention due to their differences in properties such as penetration, circulation, and toxicity compared to bulk materials. This thesis mainly focused on using 20 nm iron oxide nanoparticles as siRNA delivery carriers under the alternating magnetic field and the development of a method to amplify the secretion of 150 nm exosomes from the cells, which could potentially use as a biological drug carrier.

Chapter 2 discusses a magnetically driven nanoparticle therapeutic agent delivery system, which efficiently modified the gene expression post-transcriptionally. In this work, we examined whether the caged-shaped 20nm iron oxide nanoparticles (IO-nanocages) can …

Quality Management And Oversight Of Texas Forensic Science Service Providers, Sarah P. Chu

Dissertations, Theses, and Capstone Projects

Forensic science oversight in the U.S. largely relies upon voluntary third-party forensic laboratory accreditation programs. Without a national system of regulation and given the highly fragmented local systems of control, few forensic science service providers (FSSPs) are subject to regulatory oversight beyond their third-party accreditors. Texas is unique in its establishment of a robust statewide oversight system and a strong governmental culture of transparency, permitting this study of forensic quality management. This study consisted of two parts. The first part of this dissertation characterized and analyzed quality incident reports (QIRs) published by the Texas Department of Public Safety Crime Laboratory …

Synthesis And Characterization Of Polymer-Based Complex Nanomaterials, Prashun G. Roy

Dissertations, Theses, and Capstone Projects

The original research work in this dissertation is about the use of polymers in two significantly important areas. One involves creating mesoporous silica materials with various morphologies using a mixed Pluronic surfactant system made up of two poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) surfactants, one of which contains long hydrophilic (PEO) blocks and the other has a significantly higher proportion of hydrophobic PPO . In addition, a glucose responsive core-shell type microgel was also developed for shifting the glucose responsive volume phase transition by using polymeric nanomaterials.

Chapter 1 of the dissertation discussed some historical background of synthesis and uses of …