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Test Problem Generation And Metaheuristic Selection For The Multidemand Multidimensional Knapsack Problem, Matthew E. Scherer

Theses and Dissertations

This work focuses on instance generation methods for the multi-demand multidimensional knapsack problem (MDMKP). Specifically, instance space analysis (ISA) is used to characterize the landscape of existing instances and validate the novelty of new instances generated with a novel problem generation method, the primal problem instance generator (PPIG). The instance generator is capable of producing feasible, diverse, and challenging instances by directly controlling the problem features. PPIG contributes to the previous collections of instances and is validated through instance space analysis. The research presents an in-depth empirical evaluation of existing solution procedures for the MDMKP. The portfolio of metaheuristics examined …

Tailoring Strontium-Promoted Alumina-Zirconia Supported Ni-Catalysts For Enhanced Co2 Utilization Via Dry Reforming Of Methane: Sr Loading Effects And Process Optimization, Ahmed Al-Fatesh, Maher Alrashed, Radwa El-Salamony, Mai H. Roushdy, Saba Alwan, Ahmed Osman, Mohamed Bayazed, Anis Fakeeha, Ahmed Ibrahim, Rawesh Kumar

Chemical Engineering

An urgent need exists in the dry reforming of methane (DRM) community for a cost-effective and high performance catalyst system to facilitate the industrial production of H2-rich syngas. In this study, we propose a catalyst composed of a 10 wt% ZrO2-90 wt% Al2O3 support, Ni as active sites, and a strontium promoter, which offers a promising solution. Characterization of the 5NixSr/10Zr+Al catalyst series (x = 0–4 wt%) was conducted using XRD, surface area and porosity analysis, and TPR, TPO, TPD techniques, revealing the stability of metallic Ni derived from the reduction of "moderately interacted NiO-species" under oxidizing-reducing conditions. Incorporating 3 …

Identifying Sources Of Antibiotic Resistance Genes In The Environment Using The Microbial Find, Inform, And Test Framework, Corinne Wiesner-Friedman, Rachelle E. Beattie, Jill R. Stewart, Krassimira R. Hristova, Marc L. Serre

Biological Sciences Faculty Research and Publications

Introduction: Antimicrobial resistance (AMR) is an increasing public health concern for humans, animals, and the environment. However, the contributions of spatially distributed sources of AMR in the environment are not well defined.

Methods: To identify the sources of environmental AMR, the novel microbial Find, Inform, and Test (FIT) model was applied to a panel of five antibiotic resistance-associated genes (ARGs), namely, erm(B), tet(W), qnrA, sul1, and intI1, quantified from riverbed sediment and surface water from a mixed-use region.

Results: A one standard deviation increase in the modeled contributions of elevated AMR from bovine sources or land-applied waste sources [land application …

Gross Hematuria And Lower Urinary Tract Symptoms Associated With Military Burn Pits Exposures In Us Veterans Deployed To Iraq And Afghanistan, Mosammat M. Perveen, Henry E. Mayo-Malasky, Mary F. Lee-Wong, Julie M. Tomaska, Edward Forsyth, Amy Gravely, Mark A. Klein, Janeen H. Trembley, Tammy A. Butterick, Robert A. Promisloff, Pamela K. Ginex, Paul Barach, Anthony M. Szema

College of Population Health Faculty Papers

OBJECTIVE: The aim of the study is to describe rates of hematuria and other lower urinary tract symptoms, including self-reported cancer rates, among veterans postburn pits emissions exposure during deployment to Iraq and Afghanistan.

METHODS: US post-9/11 veterans with burn pits emissions exposure confirmed via DD214 forms in the Burn Pits360.org Registry were sent a modified survey. Data were deidentified and anonymously coded.

RESULTS: Twenty-nine percent of the 155 respondents exposed to burn pits self-reported seeing blood in their urine. The average index score of our modified American Urological Association Symptom Index Survey was 12.25 (SD, 7.48). High rates of …

A Bkbx Frankenstein

Theatre and Performance Studies Programs

Made for adventurous audience members ages 12+, the show remixes and riffs on the themes found in Mary Shelley's gothic horror classic: technology, creation, and modern monsters. Stitching together a mix of favorite restaged repertoire with a new cast and fresh interstitials, "A BKBX Frankenstein" is a contemporary delight on an ancient form of storytelling.

Self-Assessment Tool (Sat) For Improving How Higher Education Institutions And Stem Units Address Sexual Harassment By Faculty And Administrators, Susan Saab Fortney, Theresa Morris

Faculty Scholarship

Based on their systematic review of studies related to sexual harassment and higher education, researchers describe sexual harassment as an epidemic in higher education that constitutes one of the major challenges to an inclusive work and study environment. Persons involved in addressing sexual harassment recognize the extremely high institutional and individual costs associated with dealing with sexual harassment. Rather than reacting to sexual harassment that occurs, this Self-Assessment Tool assists institutions in examining and improving how they prevent and address sexual harassment.

The tool focuses on issues related to sexual harassment by faculty, administrators, and persons in supervisory positions, including …

Comparison Of Thickness Between Thermoformed And Printed Orthodontic Aligners, Omar Souman

Loma Linda University Electronic Theses, Dissertations & Projects

Introduction: The fabrication of thermoformed orthodontic aligners involves processes that irreversibly alter material properties, resulting in aligners that exhibit high variation in thickness. The non-uniform thickness can lead to unpredictable forces that can adversely affect orthodontic tooth movement. With recent technological advancements enabling the printing of orthodontic aligners, it is of clinical interest to investigate their variation of thickness.

Purpose: This study utilized Micro-Computed Tomography (Micro-CT) and Geomagic Control X metrology software to compare the thickness of thermoformed and direct printed aligners.

Materials and Methods: Intraoral scans of 13 orthodontic patients were used to generate standard tessellation …

Biomolecule-Functionalized Nanoformulations For Prostate Cancer Theranostics, Fnu Pranav, Partha Laskar, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu

School of Medicine Publications

Highlights

• Nanomaterials for prostate cancer therapy and their current clinical trial status.

• Strategies for conjugating different biomolecules with nanomaterials.

• Biofunctionalized nanosystems used for the detection of different prostate-specific biomarkers and direct visualization of tumor cells.

• Biofunctionalized nanosystems used for the targeted delivery of drugs and biomacromolecules.

• Design and synthesis of biomimetic nanomaterials especially exosomes and viral particle functionalized nanomaterials against prostate cancer.

Abstract

Background

Even with the advancement in the areas of cancer nanotechnology, prostate cancer still poses a major threat to men’s health. Nanomaterials and nanomaterial-derived theranostic systems have been explored for diagnosis, imaging, and therapy for different types …

Colonial Investments: The Global Coordinates Of The English Political Imaginary, 1628–1668, Nathan D. Nikolic

Dissertations, Theses, and Capstone Projects

The main question my dissertation attempts to address is: what role did the expansion of English colonial trades play in the transformation of English society and government between the Petition of Right and the early years of the Restoration (1628-1668)? My thesis is that during this period, colonial expansion rose to the level of a general national interest and that many early seventeenth-century texts index the complexities and tensions of this development. As a small but very organized group of merchants, peers, and MPs mobilized the military and financial technologies of colonization to support Parliament’s war against Charles I, their …

This Little Light Of Mine: The History Of The Amalgamated Nursery School, Kimberly F. Vanderbilt

Dissertations, Theses, and Capstone Projects

This research focuses on the history of one small nursery school to analyze the factors that influenced the school: the labor unionists founders, the changing neighborhoods of the Bronx, the Progressive Education Movement and the Women's Leadership Movements that helped define and support the school. Recent policy changes have had impact on this school and on all early childhood programs in New York City.

Fifteenth-Century Sienese Art In Its International Setting: A Case Study Of Cross-Cultural Exchange In Italy And Beyond, Maria Lucca

Dissertations, Theses, and Capstone Projects

Scholars often frame the Republic of Siena as isolationist and inward-looking, yet from its beginning in 1262 the city-state was internationally vital, sending artists to work in foreign cities and calling upon foreign artists to do significant work in Siena. Although Siena temporarily retreated from this internationalism to a period of relative cultural autonomy in the mid-Trecento, in the early Quattrocento it re-opened the gates of its medieval walled city to artistic interchange between Sienese and Florentine sculptors, setting in motion the dramatic shift that occurred in the mid-Quattrocento. Sienese sculptors embraced the Renaissance artistic humanism flourishing in Florence and …

Complexity Of Verification In Self-Assembly With Prebuilt Assemblies, David Caballero, Timothy Gomez, Robert Schweller, Tim Wylie

Computer Science Faculty Publications

We analyze the complexity of two fundamental verification problems within a generalization of the two-handed tile self-assembly model (2HAM) where initial system assemblies are not restricted to be singleton tiles, but may be larger prebuilt assemblies. Within this model we consider the producibility problem, which asks if a given tile system builds, or produces, a given assembly, and the unique assembly verification (UAV) problem, which asks if a given system uniquely produces a given assembly. We show that producibility is NP-complete and UAV is coNPNP -complete even when the initial assembly size and temperature threshold are both bounded by a …

Stromal-Derived Nrg1 Enables Oncogenic Kras Bypass In Pancreas Cancer, Jincheng Han, Jiaqian Xu, Yonghong Liu, Shaoheng Liang, Kyle A Labella, Denise J Spring, Ronald A Depinho

Faculty, Staff and Student Publications

Activating KRAS mutations (KRAS*) in pancreatic ductal adenocarcinoma (PDAC) drive anabolic metabolism and support tumor maintenance. KRAS* inhibitors show initial antitumor activity followed by recurrence due to cancer cell-intrinsic and immune-mediated paracrine mechanisms. Here, we explored the potential role of cancer-associated fibroblasts (CAFs) in enabling KRAS* bypass and identified CAF-derived NRG1 activation of cancer cell ERBB2 and ERBB3 receptor tyrosine kinases as a mechanism by which KRAS*-independent growth is supported. Genetic extinction or pharmacological inhibition of KRAS* resulted in up-regulation of ERBB2 and ERBB3 expression in human and murine models, which prompted cancer cell utilization of CAF-derived NRG1 as a …

Carm1 Arginine Methyltransferase As A Therapeutic Target For Cancer, Margarida Santos, Jee Won Hwang, Mark T Bedford

Faculty, Staff and Student Publications

Coactivator-associated arginine methyltransferase 1 (CARM1) is an arginine methyltransferase that posttranslationally modifies proteins that regulate multiple levels of RNA production and processing. Its substrates include histones, transcription factors, coregulators of transcription, and splicing factors. CARM1 is overexpressed in many different cancer types, and often promotes transcription factor programs that are co-opted as drivers of the transformed cell state, a process known as transcription factor addiction. Targeting these oncogenic transcription factor pathways is difficult but could be addressed by removing the activity of the key coactivators on which they rely. CARM1 is ubiquitously expressed, and its KO is less detrimental in …

Gut Oncomicrobiome Signatures (Goms) As Next-Generation Biomarkers For Cancer Immunotherapy, Andrew Maltez Thomas, Marine Fidelle, Bertrand Routy, Guido Kroemer, Jennifer A Wargo, Laurence Zitvogel

Faculty, Staff and Student Publications

Oncogenesis is associated with intestinal dysbiosis, and stool shotgun metagenomic sequencing in individuals with this condition might constitute a non-invasive approach for the early diagnosis of several cancer types. The prognostic relevance of antibiotic intake and gut microbiota composition urged investigators to develop tools for the detection of intestinal dysbiosis to enable patient stratification and microbiota-centred clinical interventions. Moreover, since the advent of immune-checkpoint inhibitors (ICIs) in oncology, the identification of biomarkers for predicting their efficacy before starting treatment has been an unmet medical need. Many previous studies addressing this question, including a meta-analysis described herein, have led to the …

Inorganic Fertilizer Use And Its Association With Rice Yield Gaps In Sub-Saharan Africa, Jean-Martial Johnson, Ali Ibrahim, Elliott Ronald Dossou-Yovo, Kalimuthu Senthilkumar, Yasuhiro Tsujimoto, Kazuki Saito

Faculty, Staff and Student Publications

Where and which countries should receive higher priority for improving inorganic fertilizer use in rice fields in sub-Saharan Africa (SSA)? This study addressed this question by assessing the spatial variation in fertilizer use and its association with rice yield and yield gap in 24 SSA countries through a systematic literature review of peer-reviewed papers, theses, and grey literature published between 1995 and 2021. The results showed a large variation in N, P, and K fertilizer application rates and rice yield and an opportunity for narrowing the yield gap by increasing N and P rates, especially in irrigated rice systems. We …

Going Circular: History, Present, And Future Of Circrnas In Cancer, Giuseppina Pisignano, David C Michael, Tanvi H Visal, Radu Pirlog, Michael Ladomery

Faculty, Staff and Student Publications

To date, thousands of highly abundant and conserved single-stranded RNA molecules shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional molecules that have been shown to regulate gene expression transcriptionally and post-transcriptionally and exhibit distinct tissue- and development-specific expression patterns associated with a variety of normal and disease conditions, including cancer pathogenesis. Over the past years, due to their intrinsic stability and resistance to ribonucleases, particular attention has been drawn to their use as reliable diagnostic and prognostic biomarkers in cancer diagnosis, treatment, and prevention. However, there are some critical caveats to their utility in the clinic. Their …

Autotaxin Suppresses Cytotoxic T Cells Via Lpar5 To Promote Anti-Pd-1 Resistance In Non-Small Cell Lung Cancer, Jessica M Konen, B Leticia Rodriguez, Haoyi Wu, Jared J Fradette, Laura Gibson, Jing Wang, Ignacio I Wistuba, Jianjun Zhang, Don L Gibbons

Faculty, Staff and Student Publications

Non-small cell lung cancers that harbor concurrent KRAS and TP53 (KP) mutations are immunologically warm tumors with partial responsiveness to anti-PD-(L)1 blockade; however, most patients observe little or no durable clinical benefit. To identify novel tumor-driven resistance mechanisms, we developed a panel of KP murine lung cancer models with intrinsic resistance to anti-PD-1 and queried differential gene expression between these tumors and anti-PD-1-sensitive tumors. We found that the enzyme autotaxin (ATX), and the metabolite it produces, lysophosphatidic acid (LPA), were significantly upregulated in resistant tumors and that ATX directly modulated antitumor immunity, with its expression negatively correlating with total and …

Spatially-Aware Clustering Improves Ajcc-8 Risk Stratification Performance In Oropharyngeal Carcinomas, Guadalupe Canahuate, Andrew Wentzel, Abdallah S R Mohamed, Lisanne V Van Dijk, David M Vock, Hesham Elhalawani, G Elisabeta Marai

Faculty, Staff and Student Publications

OBJECTIVE: Evaluate the effectiveness of machine learning tools that incorporate spatial information such as disease location and lymph node metastatic patterns-of-spread, for prediction of survival and toxicity in HPV+ oropharyngeal cancer (OPC).

MATERIALS & METHODS: 675 HPV+ OPC patients that were treated at MD Anderson Cancer Center between 2005 and 2013 with curative intent IMRT were retrospectively collected under IRB approval. Risk stratifications incorporating patient radiometric data and lymph node metastasis patterns via an anatomically-adjacent representation with hierarchical clustering were identified. These clusterings were combined into a 3-level patient stratification and included along with other known clinical features in a …

Efficient Targeted Learning Of Heterogeneous Treatment Effects For Multiple Subgroups, Waverly Wei, Maya Petersen, Mark J Van Der Laan, Zeyu Zheng, Chong Wu

Faculty, Staff and Student Publications

In biomedical science, analyzing treatment effect heterogeneity plays an essential role in assisting personalized medicine. The main goals of analyzing treatment effect heterogeneity include estimating treatment effects in clinically relevant subgroups and predicting whether a patient subpopulation might benefit from a particular treatment. Conventional approaches often evaluate the subgroup treatment effects via parametric modeling and can thus be susceptible to model mis-specifications. In this paper, we take a model-free semiparametric perspective and aim to efficiently evaluate the heterogeneous treatment effects of multiple subgroups simultaneously under the one-step targeted maximum-likelihood estimation (TMLE) framework. When the number of subgroups is large, we …

Microfluidic Paper-Based Device Coupled With 3d Printed Imaging Box For Colorimetric Detection In Resource-Limited Settings, Vijay Vaishampayan, Oinam Robita Chanu, Balasubramanian Sivasamy, Muthamilselvi Ponnuchamy, Varshini Karthik, Lohith Srinivas Thotakura, Venkatesan Dhananjeyan, Ashish Kapoor

Faculty, Staff and Student Publications

Rapid and effective methods for the detection of analytes such as water contaminants, food adulterants and biomolecules are essential for the protection of public health and environmental protection. Most of the currently established analytical techniques need sophisticated equipment, centralized testing facilities, costly operations, and trained personnel. Such limitations make them inaccessible to the general populace, particularly in regions with limited resources. The emergence of microfluidic devices offers a promising alternative to overcome several such constraints. This work describes a protocol for fabricating a low-cost, open-source paper-based microfluidic device using easily available tools and materials for colorimetric detection of analytes. The …

Obesity And Renal Cell Carcinoma: Biological Mechanisms And Perspectives, Neha Venkatesh, Alberto Martini, Jennifer L Mcquade, Pavlos Msaouel, Andrew W Hahn

Faculty, Staff and Student Publications

Obesity, defined by body mass index (BMI), is an established risk factor for specific renal cell carcinoma (RCC) subtypes such as clear cell RCC, the most common RCC histology. Many studies have identified an association between obesity and improved survival after diagnosis of RCC, a potential "obesity paradox." Clinically, there is uncertainty whether improved outcomes observed after diagnosis are driven by stage, type of treatment received, or artifacts of longitudinal changes in weight and body composition. The biological mechanisms underlying obesity's influence on RCC are not fully established, but multiomic and mechanistic studies suggest an impact on tumor metabolism, particularly …

Accounting For Temporal Variability In Functional Magnetic Resonance Imaging Improves Prediction Of Intelligence, Yang Li, Xin Ma, Raj Sunderraman, Shihao Ji, Suprateek Kundu

Faculty, Staff and Student Publications

Neuroimaging-based prediction methods for intelligence have seen a rapid development. Among different neuroimaging modalities, prediction using functional connectivity (FC) has shown great promise. Most literature has focused on prediction using static FC, with limited investigations on the merits of such analysis compared to prediction using dynamic FC or region-level functional magnetic resonance imaging (fMRI) times series that encode temporal variability. To account for the temporal dynamics in fMRI, we propose a bi-directional long short-term memory (bi-LSTM) approach that incorporates feature selection mechanism. The proposed pipeline is implemented via an efficient algorithm and applied for predicting intelligence using region-level time series …

Interleukin-10 In Cancer Immunotherapy: From Bench To Bedside, Mohamad Adham Salkeni, Aung Naing

Faculty, Staff and Student Publications

Interleukin (IL)-10 was one of the first cytokines to be recognized. However, its functionality in promoting antitumor immunity was described more recently. Context- and concentration-dependent biological effects are the hallmarks of the pleiotropic role of IL-10. Despite reducing tumor-promoting inflammation, IL-10 may have a role in rejuvenating exhausted tumor-resident T cells. Contrary to the assumption that IL-10 produces an immunosuppressive tumor microenvironment (TME), it promotes activation of tumor-resident CD8+ T cells, which aids tumor rejection. Emerging data from published early-Phase trials have shown mixed results in different tumor types. In this review, we summarize the biological effects of IL-10 and …

Quantitative Longitudinal Mapping Of Radiation-Treated Prostate Cancer Using Mr Fingerprinting With Radial Acquisition And Subspace Reconstruction, Victoria Y Yu, Ricardo Otazo, Can Wu, Ergys Subashi, Manuel Baumann, Mariya Doneva, Daniel Shasha, Michael Zelefsky, Laura Cervino, Ouri Cohen

Faculty, Staff and Student Publications

MR fingerprinting (MRF) enables fast multiparametric quantitative imaging with a single acquisition and has been shown to improve diagnosis of prostate cancer. However, most prostate MRF studies were performed with spiral acquisitions that are sensitive to B0 inhomogeneities and consequent blurring. In this work, a radial MRF acquisition with a novel subspace reconstruction technique was developed to enable fast T1/T2 mapping in the prostate in under 4 min. The subspace reconstruction exploits the extensive temporal correlations in the MRF dictionary to pre-compute a low dimensional space for the solution and thus reduce the number of radial spokes to accelerate the …

Grand Strategy At The End Of History: Chinese Strategic Thought In The 21st Century And Its Western Perceptions, Daniel A. Rogers

Dissertations, Theses, and Capstone Projects

Too often does the study of grand strategy, especially as it is conducted by academics based in the United States, take on an ethnocentric perspective which would lead American audiences to believe it is their country alone which possesses a coherent grand strategy that seeks to secure the national interest and nothing more. This chauvinistic approach not only leaves the majority of the world out of the conversation of grand strategy, but also results in the characterizing of the strategic approaches of non-Western states as disruptors of the foreign policy goals of the United States. The People’s Republic of China …

Kinetics Of Photochemical And Mechanochemical Organic Reactions On Surface, Yerzhan Zholdassov

Dissertations, Theses, and Capstone Projects

Solvents used in traditional chemical processes account for a large percentage of reaction mass and waste and can pose significant environmental and health risks. The environmentally friendly nature of mechanochemistry, in addition to other benefits, makes it a promising approach for sustainable chemistry over traditional solvent-based methods. However, it is still not a widely adopted method for performing chemical reactions on an industrial scale. This is partially due to the significant challenge associated with understanding the reaction kinetics under mechanochemical conditions. Many variations of scanning probe lithography (SPL) techniques are able to manipulate the organic molecules with precise control over …

Body Check: Transgressive Body Politics Of Gina Pane, Orlan, And Deborah De Robertis, Avant-Garde Performance Artists In France, 1960s–Present, Patricia Anne Winter

Dissertations, Theses, and Capstone Projects

In the 1960s, when Gina Pane and Orlan were trying to gain a foothold in the art world, it was very much a man’s world. This created obstacles for them, yet, at the same time, being relegated to the margins, they were free to experiment and were less visible as objects of the gaze.

The point of departure of my study is the realization that a woman’s body is what most defines her identity (Alcoff, Bordo, Butler, Gonzenbach, Mulvey, Spelman, Suleiman). The female body is the material site from which I discuss how, and to what ends, women avant-garde performance …

How Smoking Became A Moral Issue: A Complex Systems Perspective On Moralization, Matthew Vanaman

Dissertations, Theses, and Capstone Projects

When something is morally wrong, it is in the moral domain; when something becomes morally wrong, it is moralized. But how do we know when something is in the moral domain, and how can we tell whether something is becoming moralized? The empirical study of morality, or a given person’s judgment of what constitutes moral virtue or vice, has historically approached these questions through one of three theoretical perspectives: cognitivism, which argues that people primarily or mostly use effortful thought to judge right from wrong; emotivism, which sees these judgments as flowing from emotion; and dual-process models, which …

Avoiding Success: How Does Fear Of Success Impact Today's Workforce?, Bradley E. Gray

Dissertations, Theses, and Capstone Projects

Fear of success refers to the anxiety experienced by individuals as they come close to accomplishing a goal, ambivalent and even paralyzed over choosing to accept or avoid success. Success fearers are more likely to avoid success, choosing to forego their goal to avoid the assumed negative repercussions that will accompany the success (Canavan, 1989). Though interest in fear of success has waned since its introduction in the 1970’s, evidence of fear of success still exists today. However, original theories of fear of success cannot explain its impact on both men and women, and little is known about how it …