Digital Commons Network^™

Coordinating The Telematic Music Performance Experience With Telemidi: Synchronising Nodes, Enhancing Musicality, And Delivering Simultaneity, Matthew Clive Bray

Theses: Doctorates and Masters

The practice of Telematic Music Performance (TMP), a subset of Network Music Performance (NMP), enables geographically remote musicians to engage in real-time musical interplay, typically occurring over a Wide Area Network (WAN: the Internet). However, the transmission of data between remote collaborators introduces millisecond latencies that obstruct the nuance of traditional human-to-human musical intercourse, and consequentially, the music generated by TMP often lacks rudimentary degrees of syncopation. Reducing network latency has been a critical focal point for research in this field, wherein effective networks support low-latency, multi-modal data transmission to enhance sensations of immersion and telepresence for participants; the sense …

Neoliberal Shifts And Strategies Of Religious Adaptation In Post-War Sri Lanka, Orlando Woods

Research Collection School of Social Sciences

Neoliberal shifts have brought about a centring of market logics, and a new focus on the individual as consumer. Some religious groups are better able to adapt to these shifts than others, which reveals the changing role of religion in people’s daily lives. This paper explores how the adaptive strategies of religious groups in response to neoliberalisation can trigger a reimagination of the role and value of religion in/to society. I illustrate these ideas through a comparative exploration of how Buddhist elites and evangelical Christians engage with theology, tradition, and the market in Sri Lanka. Whilst Buddhist elites struggle to …

Introducing Business School Research And Positive Impact, Howard Thomas

Research Collection Lee Kong Chian School Of Business

Typically, there are three main priorities, and dimensions, which interact with each other as business schools frame their visions and missions of enhancing management knowledge and producing distinctive management theories and insights. First, the processes of knowledge generation and development to produce high quality, often multi-disciplinary research outputs involving academic faculty, doctoral students and ‘tri-sector’ participants. Second, knowledge dissemination in teaching and learning activities enabling the growth of quality education at undergraduate and postgraduate levels and thus contributing to student intellectual growth and societal socio-economic development and advancement. Third, knowledge transfer through ‘tri-sector’ collaboration, engagement and practice enhancements that is …

Town Of Dunbarton, New Hampshire For The Fiscal Year Ending December 31, 2023., Dunbarton Town Representatives

Dunbarton, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Stress Biology: Complexity And Multifariousness In Health And Disease, Emily M. Sontag

Biological Sciences Faculty Research and Publications

Preserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms alike. To counteract an imbalance in cellular homeostasis transcriptional programs evolved, called the heat shock response, unfolded protein response, and integrated stress response, that act cell-autonomously in most cells but in multicellular organisms are subjected to cell-nonautonomous regulation. These transcriptional programs downregulate the expression of most genes but increase the expression of heat shock genes, including genes encoding molecular chaperones and proteases, proteins involved in the repair of stress-induced damage to macromolecules and cellular structures. …

Ai Is A Viable Alternative To High Throughput Screening: A 318-Target Study, Martin St. Maurice

Biological Sciences Faculty Research and Publications

High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, …

Importance Of Conserved Hydrophobic Pocket Region In Yeast Mitoribosomal Ml44 Protein For Mitotranslation And Transcript Preference, Jodie M. Box, Margo E. Higgins, Rosemary A. Stuart

Biological Sciences Faculty Research and Publications

The mitochondrial ribosome (mitoribosome) is responsible for the synthesis of key oxidative phosphorylation subunits encoded by the mitochondrial genome. Defects in mitoribosomal function therefore can have serious consequences for the bioenergetic capacity of the cell. Mutation of the conserved mitoribosomal mL44 protein has been directly linked to childhood cardiomyopathy and progressive neurophysiology issues. To further explore the functional significance of the mL44 protein in supporting mitochondrial protein synthesis, we have performed a mutagenesis study of the yeast mL44 homolog, the MrpL3/mL44 protein. We specifically investigated the conserved hydrophobic pocket region of the MrpL3/mL44 protein, where the known disease-related residue …

Developmental Patterns Underlying Variation In Form And Function Exhibited By House Gecko Toe Pads, Aaron H. Griffing, Tony Gamble, Ashmika Behere, Timothy E. Higham, Greta M. Keller, John Resener, Thomas J. Sanger

Biological Sciences Faculty Research and Publications

Adhesive toe pads have evolved numerous times over lizard evolutionary history, most notably in geckos. Despite significant variation in adult toe pad morphology across independent origins of toe pads, early developmental patterns of toe pad morphogenesis are similar among distantly related species. In these distant phylogenetic comparisons, toe pad variation is achieved during the later stages of development. We aimed to understand how toe pad variation is generated among species sharing a single evolutionary origin of toe pads (house geckos—Hemidactylus). We investigated toe pad functional variation and developmental patterns in three species of Hemidactylus, ranging from highly …

Bacillus Subtilis-Derived Peptides Disrupt Quorum Sensing And Biofilm Assembly In Multidrug-Resistant Staphylococcus Aureus, Kyle R. Leistikow, Daniel S. May, Won Se Suh, Gabriel Vargas Asensio, Adam J. Schaenzer, Cameron R. Currie, Krassimira R. Hristova

Biological Sciences Faculty Research and Publications

Multidrug-resistant Staphylococcus aureus is one of the most clinically important pathogens in the world, with infections leading to high rates of morbidity and mortality in both humans and animals. The ability of S. aureus to form biofilms protects cells from antibiotics and promotes the transfer of antibiotic resistance genes; therefore, new strategies aimed at inhibiting biofilm growth are urgently needed. Probiotic species, including Bacillus subtilis, are gaining interest as potential therapies against S. aureus for their ability to reduce S. aureus colonization and virulence. Here, we search for strains and microbially derived compounds with strong antibiofilm activity against multidrug-resistant S. …

Midline Brain Structures In Adult Niemann-Pick Type C Disease: A Cross-Sectional Study, Mark Walterfang, Tsutomu Takahashi, Maria A. Di Biase, Vanessa L. Cropley, Daiki Sasabayashi, Michio Suzuki, Dennis Velakoulis, Christos Pantelis

Research outputs 2022 to 2026

Objective: A range of neuropathological changes occur in the brains of individuals with adult Niemann-Pick type C disease (NPC), a recessive disorder of cholesterol trafficking that results in accumulation of cholesterol and gangliosides in lysosomes, particularly in neurons. One of the most significant regions of grey matter loss occurs in the thalami, which abut the midline. What is not known is whether these are neurodevelopmental in origin well prior to symptomatic onset. We aimed to examine other markers of midline developmental anomalies in adults with NPC. Method: We examined the size of adhesio interthalamica (AI) and cavum septum pellucidum (CSP) …

Until You're In The Chair And Executing Your Role, You Don't Know: A Qualitative Study Of The Needs And Perspectives Of People With Stroke-Related Communication Disabilities When Returning To Vocational Activity, Lucette Lanyon, Ciara Shiggins, Caroline Baker, Serena Alves Stein, Sophie O'Keefe, Emma J. Schneider, Erin Godecke, Kathryn Radford, Natasha A. Lannin

Research outputs 2022 to 2026

Background: People with communication disability after stroke experience low rates of return to vocational roles. Vocational rehabilitation is recommended; however, there are no clear guidelines informing vocational rehabilitation for people with communication disability. Understanding the needs and experiences of this population is critical to improving vocational stroke rehabilitation outcomes. Aims: This study aimed to: (1) investigate the experience of vocational rehabilitation for people with communication disability after stroke, (2) identify gaps and, (3) provide preliminary recommendations for tailored service delivery. Methods: Seven participants with an identified communication impairment following stroke were recruited from a larger clinical trial of early vocational …

A Regime Of Statutes: Building A Modern President In Gilded Age America (1873-1921), Andrea Scoseria Katz

Scholarship@WashULaw

At a time when the Supreme Court is turning its sights on the administrative state and enhancing the profile and powers of the president, it is worth recalling that behind our national complex of agencies lies a constitutional settlement that has structured government for approximately one hundred and thirty years. Its roots lie in the period from 1873-1921, and its defining values are interbranch cooperation, delegated problem-solving authority, and administrative expertise. This Article proposes to tell its story.

A century and a half ago, America was just healing from its Civil War wounds when a host of new problems descended: …

Less Discriminatory Algorithms, Pauline Kim, Emily Black, John Logan Koepke, Solon Barocas, Mingwei Hsu

Scholarship@WashULaw

Entities that use algorithmic systems in traditional civil rights domains like housing, employment, and credit should have a duty to search for and implement less discriminatory algorithms (LDAs). Why? Work in computer science has established that, contrary to conventional wisdom, for a given prediction problem there are almost always multiple possible models with equivalent performance—a phenomenon termed model multiplicity. Critically for our purposes, different models of equivalent performance can produce different predictions for the same individual, and, in aggregate, exhibit different levels of impacts across demographic groups. As a result, when an algorithmic system displays a disparate impact, model multiplicity …

Lawyering In The Age Of Artificial Intelligence, Jonathan H. Choi, Monahan Amy, Daniel Schwarcz

Scholarship@WashULaw

We conducted the first randomized controlled trial to study the effect of AI assistance on human legal analysis. We randomly assigned law school students to complete realistic legal tasks either with or without the assistance of GPT-4, tracking how long the students took on each task and blind-grading the results. We found that access to GPT-4 only slightly and inconsistently improved the quality of participants’ legal analysis but induced large and consistent increases in speed. AI assistance improved the quality of output unevenly—where it was useful at all, the lowest-skilled participants saw the largest improvements. On the other hand, AI …

Independence Through Judicialization: The Politics Surrounding Administrative Adjudicators 1929-1949, Lawrence J. Liu

Scholarship@WashULaw

One front in today’s battle to define the scope of the administrative state concerns the authority, status, and future of its 10,000-plus administrative adjudicators. Decisions by federal courts and the executive branch to increase the dependence of administrative adjudicators on the executive have sparked strong reactions from observers, with many advocating for measures to increase adjudicator “independence.” But who should administrative adjudicators be independent of, which ought to be independent, and why? Calls for administrative adjudicator independence are not new. This Article draws on primary documents produced by private actors, congressional decisionmakers, and federal executive agents to present a political …

A Proposed Technique Using Machine Learning For The Prediction Of Diabetes Disease Through A Mobile App, M. Samir Abou El-Seoud

Computer Science

With the increasing prevalence of diabetes in Saudi Arabia, there is a critical need for early detection and prediction of the disease to prevent long-term health complications. This study addresses this need by using machine learning (ML) techniques applied to the Pima Indians dataset and private diabetes datasets through the implementation of a computerized system for predicting diabetes. In contrast to prior research, this study employs a semi-supervised model combined with strong gradient boosting, effectively predicting diabetes-related features of the dataset. Additionally, researchers employ the SMOTE technique to deal with the problem of imbalanced classes. Ten ML classification techniques, including …

Redistributing Justice, Benjamin Levin, Kate Levine

Scholarship@WashULaw

This article surfaces an obstacle to decarceration hiding in plain sight: progressives’ continued support for the carceral system. Despite increasingly prevalent critiques of criminal law from progressives, there hardly is a consensus on the left in opposition to the carceral state. Many left-leaning academics and activists who may critique the criminal system writ large remain enthusiastic about criminal law in certain areas—often areas where defendants are imagined as powerful and victims as particularly vulnerable. In this article, we offer a novel theory for what animates the seemingly conflicted attitude among progressives toward criminal punishment—the hope that the criminal system can …

Against Engagement, Neil M. Richards, Woodrow Hartzog

Scholarship@WashULaw

In this Article, we focus on a key dimension of commercial surveillance by data-intensive digital platforms that is too often treated as a supporting cast member instead of a star of the show: the concept of engagement. Engagement is, simply put, a measure of time, attention, and other interactions with a service. The economic logic of engagement is simple: more engagement equals more ads watched equals more revenue. Engagement is a lucrative digital business model, but it is problematic in several ways that lurk beneath the happy sloganeering of a “free” internet.

Our goal in this Article is to isolate …

Antitrust, Amazon, And Algorithmic Auditing, Jens Frankenreiter, Abhisek Dash, Abhijnan Chakraborty, Saptarshi Ghosh, Animesh Mukherjee, Stefan Bechtold, Krishna P. Gummadi

Scholarship@WashULaw

In digital markets, antitrust law and special regulations aim to ensure that markets remain competitive despite the dominating role that digital platforms play today in everyone's life. Unlike traditional markets, market participant behavior is easily observable in these markets. We present a series of empirical investigations into the extent to which Amazon engages in practices that are typically described as self-preferencing. We discuss how the computer science tools used in this paper can be used in a regulatory environment that is based on algorithmic auditing and requires regulating digital markets at scale.

Sticky Charters? The Surprisingly Tepid Embrace Of Officer-Protecting Waivers In Delaware, Jens Frankenreiter, Eric L. Talley

Scholarship@WashULaw

This article investigates the reaction to a much-heralded 2022 legal reform in Delaware that permitted a corporation’s charter to exculpate its officers from monetary exposure for breaching their fiduciary duty of care. To isolate reactions to this statutory reform, we make extensive use of generative AI tools to identify and interpret charter amendments that introduce officer-facing waivers. We find a surprisingly tepid rate of uptake among Delaware corporations through the end of the first post-reform year, notwithstanding widespread predictions that corporate entities would quickly storm the exculpation exits once permitted to do so.

Our study makes two contributions to the …

Sex & Startups, Jens Frankenreiter, Talia B. Gillis, Eric L. Talley

Scholarship@WashULaw

Venture capital is widely perceived to have a gender problem. Both founders seeking capital and the investors themselves are overwhelmingly male, fomenting concerns about how—and how fairly—the VC sector distributes its economic gains. Although gender disparities in funding are well documented, we still know little about whether the governance of VC-backed startups similarly manifests gender imbalances. This knowledge gap is critical, since VC investments often carry strings attached, in the form of cash flow and control rights that can vary substantially from deal to deal.

This study unveils a first-of-its-kind dataset that offers detailed insights into the governance of VC-backed …

The Use Of Variable Coil Pitch Of Helical Tube On The Hydro-Thermal Performance Improvement, Shayan Pourhemmati, Hussein A. Mohammed, Abdellah Shafieian

Research outputs 2022 to 2026

The use of helical tubes in heat transfer appliances is desirable due to their better heat transfer characteristics, but the higher pressure drop decreases the overall performance. The variation of pitch design of a helical tube is proposed to alleviate this situation so that the pitch number does not remain constant in the total tube length. A total of six variable pitch numbers with three different diameters are proposed and investigated on the thermal and fluid characteristics. To better understand the helical tube efficiency, PEC (performance evaluation criteria) is selected as a performance indicator in the present work and simulations …

Microbes Of Biotechnological Importance In Acidic Saline Lakes In The Yilgarn Craton, Western Australia, Katelyn Boase, Talitha Santini, Elizabeth Watkin

Research outputs 2022 to 2026

Acidic salt lakes are environments that harbor an array of biologically challenging conditions. Through 16S rRNA, 18S rRNA, and ITS amplicon sequencing of eight such lakes across the Yilgarn Craton of Western Australia, we aim to understand the microbial ecology of these lakes with a focus on iron- and sulfur-oxidizing and reducing microorganisms that have theoretical application in biomining industries. In spite of the biological challenges to life in these lakes, the microbial communities were highly diverse. Redundancy analysis of soil samples revealed sulfur, ammonium, organic carbon, and potassium were significant diversities of the microbial community composition. The most abundant …

Cellular Structure Mediated Dislocation Regulation In Additively Manufactured Refractory High Entropy Alloy, Changxi Liu, Lechun Xie, Lai-Chang Zhang, Liqiang Wang

Research outputs 2022 to 2026

A Ti1.5Nb1Ta0.5Zr1Mo0.5 (TNTZM) refractory high entropy alloy (HEA) with a cellular structure was successfully fabricated by laser powder bed fusion (L-PBF). Compression testing and cyclic deformation testing results revealed that, in the cellular structure, the cell walls could store dislocations. Furthermore, the local chemical order (LCO) plays a crucial role in controlling dislocations within the cell wall region. The LCO not only facilitates dislocation slip but also generates additional lattice distortion upon stress-induced LCO destruction to enable dislocation pinning. This work offers novel insights into the microstructure of additively manufactured refractory HEAs and uncovers a distinct dislocation regulation mechanism.

The Association Between Plasma Igg N-Glycosylation And Neonatal Hypoxic–Ischemic Encephalopathy: A Case-Control Study, Liangao Wang, Xinxia Lu, Meng Wang, Xuezhen Zhao, Peirui Li, Haitao Zhang, Qingtang Meng, Yujing Zhang, Yingjie Wang, Wei Wang, Long Ji, Haifeng Hou, Dong Li

Research outputs 2022 to 2026

Introduction: Hypoxic-ischemic encephalopathy (HIE) is one of severe neonatal brain injuries, resulting from inflammation and the immune response after perinatal hypoxia and ischemia. IgG N-glycosylation plays a crucial role in various inflammatory diseases through mediating the balance between anti-inflammatory and pro-inflammatory responses. This study aimed to explore the effect of IgG N-glycosylation on the development of HIE. Methods: This case-control study included 53 HIE patients and 57 control neonates. An ultrahigh-performance liquid chromatography (UPLC) method was used to determine the features of the plasma IgG N-glycans, by which 24 initial glycan peaks (GPs) were quantified. Multivariate logistic regression was used …

Blind Source Separation And Denoising Of Underwater Acoustic Signals, Ruba Zaheer, Iftekhar Ahmad, Quoc Viet Phung, Daryoush Habibi

Research outputs 2022 to 2026

Due to the addition of new underwater vessels and other natural noise contributors, the underwater environment is becoming congested and noisy. Undersea monitoring sonobuoys receive multiple mixed acoustic signals from different vessels that need to be separated and identified in the presence of underwater noise (UWN). It is extremely challenging to separate highly correlated acoustic signals from a noisy mixture without prior knowledge of mixing process and propagation channel. Also, in many cases, the separated signals from the noisy mixture doesn’t accurately describe the correct signal. This study proposes a novel multi-stage method to separate underwater acoustic source signals from …

Grain Boundary Engineering: An Emerging Pathway Toward Efficient Electrocatalysis, Xiaomin Xu, Yijun Zhong, Magdalena Wajrak, Tejas Bhatelia, San Ping Jiang, Zongping Shao

Research outputs 2022 to 2026

Electrochemical transformation processes involving carbon, hydrogen, oxygen, nitrogen, and small-molecule chemistries represent a promising means to store renewable energy sources in the form of chemical energy. However, their widespread deployment is hindered by a lack of efficient, selective, durable, and affordable electrocatalysts. Recently, grain boundary (GB) engineering as one category of defect engineering, has emerged as a viable and powerful pathway to achieve improved electrocatalytic performances. This review presents a timely and comprehensive overview of recent advances in GB engineering for efficient electrocatalysis. The beneficial effects of introducing GBs into electrocatalysts are discussed, followed by an overview of the synthesis …

Role Of Supply Chain Management In Improving Competitive Advantage Of Indonesian Small And Medium Enterprises, Hotlan Siagian, Sautma Ronni Basana, Zeplin Jiwa Husada Tarigan, Maya Novitasari, Ferry Jie

Research outputs 2022 to 2026

Global competition has forced companies, including small and medium enterprises (SMEs), to improve their competitive advantage. Supply chain management practices are the ways to improve the competitive advantage, particularly in the global competition context. However, there is still doubt SMEs can compete globally, considering they face limited resources, skilled workforce, and business networks. Therefore, this study aims to examine the influence of supply chain management practices, covering cross-functional integration, partnership, responsiveness, and resilience. Moreover, this study has examined which practices dominate in improving competitive advantage. The quantitative study involved 445 SMEs located in East Java, Indonesia. The respondents are supervisors …

Work-Integrated Learning In The Humanities, Arts And Social Sciences: Where To From Here?, Denise Jackson, Elizabeth Cook

Research outputs 2022 to 2026

Amidst increasing pressures on Humanities, Arts, and Social Sciences (HASS) disciplines regarding graduate career readiness, this study examines HASS student participation in work-integrated learning (WIL) and its impacts on employability and short-term employment outcomes, using data from the Australian Graduate Outcomes Survey from 2020 to 2023. The research examined the extent of participation across WIL types (work-based, non-workplace and global) and its influence on graduates’ perceived employability and employment outcomes (full-time employment and perceived overqualification), while investigating demographic differences using descriptive analysis and logistic regression models. Results indicated rising WIL participation yet identified disparities by activity type and among student …

Conceptualising Project Environmental Impact Assessment For Enhancement: No Net Loss, Net Gain, Offsetting And Nature Positive, Angus Morrison-Saunders, Luis Sánchez

Research outputs 2022 to 2026

With declining biodiversity worldwide, the need for development proposals to deliver positive, not negative, environmental outcomes is clear. Arguably, this is a long-standing goal of environmental impact assessment (EIA). This article explores the extent to which current project EIA practice can achieve enhancement, no net loss or a net gain of biodiversity and Nature Positive goals. Using reflexivity, a conceptual approach is applied to policies and examples from practice. The environmental enhancement goal of EIA is explained. The mitigation hierarchy is applied to a hypothetical mining example for accomplishing no net loss/net gain of biodiversity through offsets. Nature Positive is …