Digital Commons Network^™

Alexander Hamilton And Administrative Law: How America's First Great Public Administrator Informs And Challenges Our Understanding Of Contemporary Administrative Law, Rodger D. Citron

Cleveland State Law Review

Alexander Hamilton’s recognition and reputation have soared since the premiere of "Hamilton," Lin-Manuel Miranda’s musical about him in 2015. For lawyers, Hamilton’s work on the Federalist Papers and service as the nation’s first Treasury Secretary likely stand out more than other aspects of his extraordinary life. Politics and economics were fundamental concerns addressed by the Framers in a number of ways, including what we now refer to as administrative law—the laws and procedures that guide government departments (or, as we say today, agencies). Indeed, "Hamilton" reminds us that questions of administration and administrative law have been with us since the …

Concealing More Than Your Affairs: A Deep Dive Into The World Of Cryptocurrency And Its Future Influence On Family Law In Ohio, Milica Prica

Cleveland State Law Review

This Note dives into the world of cryptocurrency and family law in Ohio. With its current popularity and dramatic fluctuations, cryptocurrency has created a new legal issue in the family law practice. Specifically, this Note focuses on the concealability of Bitcoin and how that influences division of property, spousal support, and child support in Ohio divorce proceedings and settlements. To tackle this issue, this Note begins with the history of Bitcoin, its value since the beginning, as well as the reason for its fluctuations. This Note also looks into what makes Bitcoin and other cryptocurrency forms so concealable. This Note …

From Models To Mannequins: The Oxymoronic Equation Of International Labor Law Standards In The World Of Fashion, Namrata Bhowmik, Naman Anand

Cleveland State Law Review

Fashion law is an emerging field that addresses the legal issues that arise in the fashion industry. With the rapid growth and globalization of the fashion industry, there is an increasing need for specialized legal guidance in this area. Fashion law encompasses a wide range of legal issues, including intellectual property, contract law, employment law, international trade law, and environmental law.

One of the main drivers behind the need for fashion law is the rise of counterfeiting and intellectual property theft in the fashion industry. With the proliferation of ecommerce and social media, it has become easier than ever for …

Enhancing Student Leadership Skills Through Project-Based Learning In The Postgraduate Research Experience, Enung Hasanah, M Ikhsan Al Ghazi, M. Ikhwan Al Badar, Fauzia Fauzia M.A.

The Qualitative Report

Project-based learning (PjBL) is one of the learning models recognized by education experts as an effective method of achieving learning objectives in developing process skills; however, few studies have examined its potential for fostering leadership skills. This study aims to investigate postgraduate teacher students' experiences with project-based learning as a means of developing students leadership skills. The research involved 24 postgraduate students and utilized a qualitative approach to data collection and analysis. The findings reveal that while some aspects of project-based learning were perceived as straightforward, other steps were deemed challenging, particularly those that involved higher order thinking skill and …

Examining Immigrant Experiences In Asset Building: Implications For Asset-Based Policies, Yingying Zeng

Brown School Graduate Student Theses and Dissertations

The economic integration of immigrants has long interested researchers and policymakers, with late but now growing attention on their asset- and wealth-building. Current research on immigrants’ asset building has largely focused on their individual-level characteristics, and not much on opportunities and constraints related to policy arrangements. This dissertation addresses the selection, adaptation, and impacts of immigration, with a goal to expand knowledge about asset-based social welfare policy in light of immigrants’ experiences. This investigation leverages two nationally representative datasets, the New Immigrant Survey and the National Longitudinal Survey of Youth (1997), to understand immigrants’ asset accumulation and intergenerational wealth mobility. …

A Prediction Of Young's Modulus For Tin Containing Phosphate Glasses Using Quantitative Structural Information, Tatsuki Shimizu, Akira Saitoh, Uwe Hoppe, Grégory Tricot, Richard K. Brow

Materials Science and Engineering Faculty Research & Creative Works

A Rigid Unit Packing Fraction (RUPF) Model Was Used to Better Understand the Influence of Local Structural Units on the Young's Elastic Modulus (E) of Binary and Ternary Tin Phosphate Glasses. Quantitative Analyses of the Units that Constitute the Glass Structure, Obtained from X-Ray/neutron Diffraction and 31P MAS-NMR Spectroscopy, Were Used to Calculate Polyhedral Packing Fractions that, with Tabulated Bond Dissociation Energies, Were Used to Predict E based on a Modification of the Makashima-Mackenzie Relationship, Which Uses Ion Sizes to Calculate Packing Fractions. Predictions based on the RUPF Model Are Better Than Those based on Ion Sizes, and Extending the …

The Effect Of Demographic Imbalance On Crime, Maher Bhadri

Theses

This study investigates demographic imbalance on crimes in the UAE by analyzing a record of crimes from 2020 to 2022 using descriptive and inferential statistics. The findings reveal gender, marital status, and age imbalance among crime offenders in the UAE. Males, married individuals, and individuals in their 30s are more prevalent in committing crimes. Certain countries, accused individuals, and certain types of crimes are also more frequent in the UAE. Policymakers and law enforcement agencies can use these insights to develop targeted interventions to reduce crime rates in the country. Future studies should investigate the underlying causes of these imbalances …

A Novel Mrna Delivery Strategy Employing Adenovirus Piggyback Mrna Binders Via Catcher/Tag Molecular Glue, Kexin Geng

McKelvey School of Engineering Graduate Student Theses & Dissertations

mRNA-based therapeutics open a new era for the prevention and treatment of a wide range of diseases. However, existing mRNA delivery vehicles have limited repertoires for dendritic cell targeting and intranasal administration which are two paramount delivery pathways of significant advantages for treating cancer and infectious respiratory diseases. Adenovirus (Ad) with well-deciphered viral genomes and intensive-studied structure biology has been developed for DCs-targeted cancer vaccines and intranasal COVID vaccines. In light of these virtues, Ad presents as the “off-the-shelf” tool possessing well-defined manufacturable capabilities and translatable feasibility that perfectly complements the current limitations of mRNA delivery. In this study, we …

Reflectance Quantitative Polarized Light Imaging For Microstructural Evaluation Of Musculoskeletal Soft Tissues, Leanne Elizabeth Iannucci

McKelvey School of Engineering Graduate Student Theses & Dissertations

Musculoskeletal soft tissue injury is common and can lead to debilitating pain, loss of tissue function, and overall decrease in quality of life. Proper biomechanical function of musculoskeletal soft tissues is dictated by their hierarchically organized collagenous extracellular matrices, which are disrupted in periods of disease or injury. To best understand dynamic structure-function relationships of these tissues in normal and pathological conditions, it is imperative to be able to visualize collagen microstructure using a quantitative, high spatiotemporal resolution imaging modality. The innate birefringence associated with collagen fibers permits the use of biomedical polarimetry techniques to probe collagen in a specific …

Two-Dimensional Field Effect Transistor, Yimeng Li

McKelvey School of Engineering Graduate Student Theses & Dissertations

As silicon-based field-effect transistors (FETs) approach their physical limits with channel lengths approaching 5 nm, the search for new semiconductor materials that can surpass this limit has become urgent. Two-dimensional layered semiconductor nanomaterials, represented by graphene, have emerged as promising candidates due to their unique physical, mechanical, and chemical properties. Unlike traditional silicon-based FETs, two dimensional (2D) layered nanomaterials are held together by van der Waals forces between layers, with no dangling bonds on the material surface, which can effectively address the short-channel effect issue faced by traditional silicon-based FETs. However, unlike traditional silicon-based FETs, which have matured fabrication systems, …

Advancements In Magnetic Resonance Image Guided Radiotherapy, Austen Curcuru

McKelvey School of Engineering Graduate Student Theses & Dissertations

Magnetic resonance image guided radiation therapy (MRgRT) devices are a recently developed technology that integrate the excellent soft tissue contrast and real-time imaging capabilities of MRI with a medical linear accelerator (Linac). This provides an unprecedented ability to guide and adapt radiation therapy treatments based on real-time cine imaging. However, the merging of these technologies has come with unique challenges. MRI lacks the geometric fidelity of computed tomography (CT). Spatial inaccuracies in MRI can result from magnetic field (B0) or center frequency variations, gradient-induced eddy currents, and magnetic field gradient imperfections (e.g., nonlinearities, poor calibration, concomitant fields, and unsatisfactory electronic …

An Investigation Of Peripheral Nerve Imaging Methods And Therapeutic Electrical Stimulation Parameters, Nathan Kennedy Birenbaum

McKelvey School of Engineering Graduate Student Theses & Dissertations

Treatment of peripheral nerve injuries depends on an accurate diagnosis of their severity to inform treatment options. Current clinical practice often necessitates delayed electrodiagnostics or surgical exploration of the injury site to determine whether surgical repair is necessary. This delays patient treatment, increases the time that muscle is denervated, and may impose an unnecessary surgery if surgical repair is not ultimately required. While imaging techniques such as diffusion tensor imaging enable visualization of healthy nerve tissue, the inflammation and axonal loss present in injured nerve obfuscates diffusion signals and confounds quantification of injury severity. Diffusion basis spectrum imaging uses multiple …

Mapping, Modifying, And Stimulating Skeletal Nerves To Explore Their Regulatory Role In Bone Metabolism, Alec Thomas Beeve

McKelvey School of Engineering Graduate Student Theses & Dissertations

The skeleton is innervated by sensory and sympathetic nerves, which are known facilitators of pain and vasoregulation. Recent studies suggest that nerves in bone play an additional direct role in regulating bone metabolism through local release of neuropeptides near bone cells; however, this remains controversial. The overall hypothesis of this thesis is that skeletal nerves are therapeutic targets for increasing bone mass and enhancing bone health. To address the feasibility of nerve-targeted skeletal therapeutics, the work in this thesis explores mapping, modification, and stimulation of nerves in bone and the subsequent effects on bone formation and metabolism.Bone is innervated by …

Synthetic Biology Approaches For Genome-Wide Regulatory Response Characterization, Yichao Han

McKelvey School of Engineering Graduate Student Theses & Dissertations

Bacteria can survive and adapt to various environments by changing their gene expression. This process is controlled by both transcription factors and shared cellular resources. Elucidating the regulatory responses in bacteria at the genome scale is crucial for biomedical and biotechnology applications. To date, even for the best-characterized bacterium, Escherichia coli, the regulatory interactions of more than 60% of operons are still unclear. In this thesis, I described two synthetic biology methods that allow the perturbation of key component concentrations and the measurement of gene expression response systematically. I characterized two types of regulatory processes: transcriptional regulation and shared resource …

Numerical Simulation, Turbulence Modeling And Active Flow Control Of High Lift Aerodynamic Flows, Karsten Hendrickson

McKelvey School of Engineering Graduate Student Theses & Dissertations

The accurate predictions of 3D high lift flows have proven to be a significant challenge for Computational Fluid Dynamics (CFD) using the Reynolds-Averaged Navier-Stokes (RANS) equations with a turbulence model. While RANS methods typically require less computational resources than Scale Resolving Simulation (SRS) methods, they generally struggle to accurately predict flow separation and the complex interactions that occur between the fuselage, different elements of the wing, the engine nacelle, and the accompanying support hardware. As a result, significant effort has been put in improving the accurate prediction of these flows with the goal of developing better computational methodologies and turbulence …

Mechanisms Of Kcnq1-Calmodulin Channel Complex Activation To Dual Open States, Po Wei Kang

McKelvey School of Engineering Graduate Student Theses & Dissertations

Voltage-gated potassium channels (KV) facilitate cellular excitability essential for cardiac contraction and neuronal spiking. In response to changes in the membrane potential, KV channels conduct transmembrane K+ flux to terminate action potentials. Myriad drugs target KV channels to achieve therapeutic goals such as anti-arrhythmic and anti-convulsant effects. Owing to their physiological significance, KV channels are exquisitely regulated by a cohort of auxiliary proteins and signaling molecules. The KCNQ1 or KV7.1 voltage-gated potassium channel stands out as an archetype in this regard. Modulators such as the KCNE subunit family, membrane lipid PIP2, and calmodulin (CaM) enable KCNQ1 to conduct phenotypically distinct …

Moment And Heuristic Approaches To Control And Stabilization Of Dynamic Populations, Xin Ning

McKelvey School of Engineering Graduate Student Theses & Dissertations

Large-scale dynamic population systems are prevalent in diverse domains at different scales from cell to society. Robust control of such ensemble systems, consisting of a vast collection of isolated or interconnected, nearly identical dynamical units is compelling to enable many cutting-edge applications, such as nuclear magnetic resonance spectroscopy and imaging in quantum control, pinning control in complex networks, and neural stimulation in brain medicine. Dynamic network systems, which consist of coupled dynamical systems, are also frequently investigated for emerging problems in finance, social science, public health, and more. In this thesis, moment-based and heuristic approaches are proposed for systems-theoretic analysis …

Developing Genetic Tools For Engineered Probiotics, Matthew Brooks Amrofell

McKelvey School of Engineering Graduate Student Theses & Dissertations

The gut microbiome is increasingly understood to play a key role in human health. Commensal gut microbes influence immunity, pathogen colonization, digestion, and brain chemistry, to name a few impacts on host physiology. As such, efforts to diagnose and treat diseases through manipulation of the microbiome are becoming more commonplace. To date, these efforts revolve around introducing defined native consortia or a single engineered strain. Engineered strains, compared to consortia, offer the advantages of known mechanisms of action, more predictable pharmacokinetics and pharmacodynamics, and easier manufacturing, among others. Safe and effective engineered strains should sense and respond to the gut …

Security Analysis Of Hidden Analog-Domain Vulnerabilities In Digital Electronic Systems: A Deep Dive Into Power Delivery Networks, Huifeng Zhu

McKelvey School of Engineering Graduate Student Theses & Dissertations

The Power Delivery Network (PDN) is an essential universal sub-system for any electronic system to operate correctly. Modern electronic systems are growing exponentially in their functionalities and complexity, and so does the sophistication of the PDNs they must depend on. Consequently, these complex PDNs create many pathways for unintended interactions and expose the system to numerous power side-channel attacks. Recent works have shown that many such vulnerabilities can be exploited remotely, making them especially potent security threats to modern electronic devices with ubiquitous connectivity. However, facing emerging PDN-based attacks, both attackers and defenders tend to treat PDN as a black …

Novel Bites, Fatima Elkabti

Arts & Sciences Graduate Student Theses and Dissertations

No abstract provided.

Painless Hylomorphism: A Deflationary Metaphysics Of Form, Graham Renz

Arts & Sciences Graduate Student Theses and Dissertations

This dissertation develops and defends a deflationary or minimalist version of hylomorphism, the Aristotelian view according to which objects are composites of matter and form. According to hylomorphists, a house has various material components—bricks and timbers—and a special, non-material or formal component that makes the bricks and timbers to be a house. Hylomorphism is intuitively appealing and explanatorily powerful, but its primary posit—form—is hard to get a firm grip on. Because of this, contemporary hylomorphists have proffered myriad accounts of form. Forms might be structures, relations, principles of unity, inherent character-grounders, abstract offices, functions, emergent powers, configurational states, activities, processes, …

Socrates The Expert, Jeremy Samuel Henry

Arts & Sciences Graduate Student Theses and Dissertations

I argue that an account of recognizing experts can be drawn from the dialogues of Plato in which Socrates is engaged in the activities he describes in the Apology, that he is an expert in recognizing experts, and that this supports his argument that no one can be an expert in ethics. I also show that his account contains a decision procedure for recognizing experts and a view about the nature of expertise (from which that procedure is derived) that is very plausible for his purpose.

Musical And Spiritual Meaning In The Franciscan Works Of Franz Liszt, Jorge Luis Modolell

Arts & Sciences Graduate Student Theses and Dissertations

Liszt’s relationship to St. Francis of Assisi was an integral part of the composer’s identity. His devotion to the saint, cultivated from an early age, served as a constant source of spiritual guidance that only grew stronger over time. Texts by St. Francis and anecdotes from the saint’s life provided the artistic incentive for a number of important works, which form the core of the present study. By examining several of these works together, with full analyses and within a broader cultural framework, this dissertation aims to arrive at a true understanding of the messages Liszt took from this figure …

The “Dread Sex Cases:” Community, Citizenship, And The Regulation Of Adult Theaters In The 1970s, Erin Barry

Arts & Sciences Graduate Student Theses and Dissertations

Through an innovative examination of scale (local, state, and national regulatory structures), space (the location of theaters, the spatial arrangements inside them) and place (the cities and suburbs in which these battles took place), my dissertation on the regulation of adult theaters in the 1970s raises compelling questions about sexuality, space and the various levels at which citizenship is enacted and policed. I utilize three Supreme Court cases, Paris Adult Theater v. Slaton, which dealt with consent and the application of community standards, Erznoznik v. Jacksonville, which addressed bans on nudity and pornography at drive-in theaters, and Young v. American …

Essays In Sovereign Default And Central Banking, Andrea Paloschi

Arts & Sciences Graduate Student Theses and Dissertations

The recent phenomenon of debt redemption is posing new challenges in emerging economies, whichare typically characterized by high levels of sovereign default risk. How do sovereign default risk and sovereign debt affect central bank independence? And how does this affect reserve accumulation in these countries? In the first chapter of this dissertation I study how business cycle fluctuations affect sovereign debt and sovereign default risk and how the de facto central bank independence is endogenously determines in emerging economies. I build a sovereign default model in which, period-by- period, the fiscal authority determines the degree of independence of the monetary …

Development Of A Multispectral Vis-Swir Imaging Modality For Cutaneous Water Assessment, Quinlan Mcgrath

McKelvey School of Engineering Graduate Student Theses & Dissertations

Inflammatory skin diseases are estimated to impact 20% of the global population and are the fourth leading cause of nonfatal disability worldwide. Diagnosis and management are predominantly based on clinician visual assessment of disease related changes in skin morphology. The qualitative nature of this method can result in misdiagnosis and underdiagnoses of treatable diseases. There persists systematic undertreatment of skin of color patients given the more subtle presentation of erythema against pigmented skin. There exists a clinical need for a quantitative and objective inflammation assessment tool that meets the needs of a diverse patient population. The accumulation of interstitial fluid …

Anillin And Dunk: The Conserved And Non-Conserved Players Regulating Myosin Dynamics In Drosophila Cleavage, Jiayang Chen

Dartmouth College Ph.D Dissertations

Cleavage is a common process during early embryogenesis. Similar to conventional cytokinesis, Drosophila cellularization, a unique form of cleavage, requires precise regulation of non-muscle myosin II ("myosin") at cleavage furrows, where myosin forms an interconnected basal array before reorganizing into individual cytokinetic rings. However, how myosin is regulated through both conserved and cellularization-specific mechanisms during this special form of cytokinesis remains unclear.

In my first project, I investigated the molecular mechanisms by which the cellularization-specific zygotic gene dunk regulates myosin at the basal array. I identified anillin (Scraps in Drosophila), a conserved scaffolding protein in cytokinesis, as the primary …

A Peeling Art, Terry Rim

Bachelor of Fine Arts Senior Papers

Action is greater than words, interaction is greater than viewing, and experience is greater than theory. So I came up with a way to make my art into an act of criticism toward consumerism. My art resembles colorful Pop Art on the surface but follows the defiant spirit of Dadaism at the core. It reveals the content full of dark humor and cynicism once the viewer “peels off” the appealing surface by interacting with it. The four artworks analyzed in the paper — Hole, The Twelephone and Alarming Alarm, Self-Destructive Ashtray, and Heavenly Cow — are designed …

On The Six-Cornered Snowflake, Jackson Hescock

Bachelor of Fine Arts Senior Papers

On the Six-Cornered Snowflake, named after Johannes Kepler’s 1611 essay on geometrically covering surfaces, is both the title of both my final thesis work and essay. Beginning with an inquiry into the nature of hand-made object as intrinsically valuable, my earlier sculptural work surrounding quilting is broken down and considered as a form of reverence for the American object. This is partly achieved through a comparison to traditional Japanese packing techniques and how my own assembly mirrors and converses with the graceful and sensitive packing of Japanese hand-made goods. Early 20^th-century flight experiments are also hand-made objects of …

Identification And Characterization Of Targets Of Metastasis In High-Grade Serous Ovarian Cancer, Emilee Nicole Kotnik

Arts & Sciences Graduate Student Theses and Dissertations

High-Grade Serous Ovarian Cancer (HGSC) is a highly metastatic cancer with the majority of patients presenting in advanced stages. Currently there are limited targeted treatment options for patients, especially for women with high metastatic tumor burdens. In order to improve patient outcomes, we have aimed to identify and characterize novel targets of metastasis utilizing sequencing from patient tumors and a functional genomic screen. First, we identified genetic alterations of metastasis and short survival by characterizing the genomic and transcriptomic alterations of primary and metastatic tumors in HGSC patients from 23 short-term survivors (overall survival (OS)5 years). We compared somatic mutations, …