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Moore’S Paradox, The First-Person, And Self-Knowledge, Matthew Warren

Graduate Theses and Dissertations

This thesis argues that Wittgenstein’s remarks on Moore’s paradox can be useful in resolving several debates concerning self-knowledge, particularly as that knowledge is manifested in avowals of belief, taking the form of sentences like “I believe that P”. Usually, sentences like these are taken to have a special first-person authority, epistemically privileged in comparison to their third-person counterparts ("He believes that P") and yet free from any reliance on evidence or observation in order to be made justifiably. It is also assumed that these avowals are functioning uniformly as reports on the speaker's mental state. Often, accounts of self-knowledge are …

Table Of Contents - Cardozo Law Review, Volume 45, Issue 6

Cardozo Law Review

No abstract provided.

Bridging The Gap: Ai And The Hidden Structure Of Consciousness, Emily Barnes, James Hutson

Faculty Scholarship

The quest to develop Artificial Intelligence (AI) systems that possess human-like consciousness necessitates a deep dive into both theoretical and practical aspects underpinning this ambitious goal. This article builds on initial philosophical explorations of AI consciousness by examining the intricate and often hidden structures that may facilitate conscious experiences in AI. Drawing from concepts in cognitive science and neuroscience, the article elucidates how AI systems can be designed to replicate the structural and functional aspects of human consciousness. The discussion includes the Hierarchy of Spatial Belongings proposed by Forti (2024), frameworks like the Integrated Information Theory (IIT), and models linking …

Regrounding The Unworldly: Carnap’S Politically Engaged Logical Pluralism, Noah Friedman-Biglin

Faculty Research, Scholarly, and Creative Activity

Recent discussions of logical pluralism trace its origins to Rudolf Carnap’s principle of tolerance; indeed, the principle is seen as one of Carnap’s lasting philosophical contributions. In this paper, I will argue that Carnap’s reasons for adopting this principle are not purely logical, but are rather founded in the Vienna Circle’s manifesto—a programmatic document that brings the Circle’s philosophical work together with a program of social change. Building on work by Uebel, Romizi, and others, I argue that we must understand the principle in light of Carnap’s role in writing the manifesto, and thus as integrated into the larger philosophical …

Building Resilience To Contagious Diseases In High Contact Services: An Investigation Of Customers’ Willingness To Dine-In At Restaurants In The Era Of Covid, Hongli Ye

All Dissertations

High customer contact services play a crucial role in our economy, providing essential interactions and experiences that drive numerous industries. However, the COVID-19 pandemic has posed significant challenges to these sectors due to their inherent characteristics, requiring close and frequent interactions. To rebound from the disruptions caused by such a contagious disease, service providers must adopt innovative strategies. Thus, this dissertation addresses the dynamic nature of building resilience strategies in high-contact services, which are affected by contagious diseases. In doing so, we propose an integrative framework that outlines essential new service resilience components, based on the CDC guidelines, to conventional …

The Role Of Kinases Signaling In Organogenesis, Fatemeh Nasehi

All Dissertations

Kinases are crucial regulators of organ development and differentiation. This thesis investi- gates the roles of TAK1, TGFbeta-Activate Kinase 1 (TAK1/Map3K7), and Akt3 kinases in skeletal, cardiac muscle, and cartilage. TAK1 is pivotal for the differentiation of various organ systems, including sinoatrial node and cartilage, and is responsible for phosphorylat- ing a diverse array of downstream kinases. We identified several novel proteins, including phospho-Akts, that are upregulated in response to TAK1 activation. We discovered severe Dilated Cardiomyopathy (DCM) and cartilage defects in Akt3 mutant mice. Although this mouse mutant has been studied for over two decades, we are the first …

How Far Does The Apple Fall? Intergenerational Processes Underlying The Attainment Of Decent Work And Implications For Occupational Health And Well-Being, Baylor A. Graham

All Dissertations

Despite decades of progress spurred by the Decent Work Agenda (International Labor Organization, 1999), efforts to improve working conditions, ensure fair wages, and establish health and well-being as fundamental standards in employment practices continue to be sorely needed. The burden of inadequate decent work has demonstrated profound effects on individual health and well-being. However, the effects of inadequate decent work are rarely investigated over long periods of time and are entirely unexplored in relation to effects on children as they age and enter the workforce themselves. Accordingly, this dissertation investigated the intergenerational effects of decent work, extending beyond the immediate …

Artificial Intelligence Integration, Concerns, Benefits, And The Need For Ethical Policies For Community Foundations And Nonprofit Organizations, Venera Balidemaj

All Dissertations

This study describes the nature and extent of Artificial Intelligence (AI) integration in philanthropic organizations and assesses the capacity and readiness of nonprofits in adopting AI for philanthropic use. Additionally, the study explores the nature and extent of perceived concerns, risks, and benefits of AI use in philanthropy and describes the current state of and need for ethical guidance. Specifically, 31 community foundation leaders and 11 nonprofit organization leaders in the United States completed an online survey. Results indicate that organizations report low readiness for AI integration as well as concerns about confidentiality and bias in the data upon which …

Improving Academic Attitudes And Motivation Using Literacy Learning In A Rural Literacy Intervention Classroom, Dannie Wilson

All Dissertations

This qualitative study focuses on the importance of reading picture books aloud to improve students' social skills capacity by utilizing literacy and social skills in a rural setting. It is designed to address a problem of practice: the need for striving third, fourth, and fifth-grade students to gain and maintain motivation and positive attitudes toward learning. An overarching research question guided this study: “How does teaching interpersonal skills affect literacy learning attitudes and motivation in a rural fringe school?” The goal was to investigate strategies through improvement science. A short Plan-Do-Study-Act cycle was used as the structure for the research …

Optimization Strategies For Political Redistricting, Blake Splitter

All Dissertations

Political redistricting has remained a hot-button issue in the United States for several decades. Every ten years, most states need to redraw their districts to account for changing populations. Sometimes, these district plans can be drawn with the malevolent intention of aiding one political party over another. This dissertation summarizes four distinct methods of drawing these districts using computer algorithms while keeping several objectives in mind. We test these approaches on the case study state of South Carolina, since it provides a sufficiently challenging problem for us to test various algorithms. We find that many of these approaches improve upon …

No Longer Unseen Or Unheard: Exploring The Connectedness Of Campus Climate With Multiracial Students’ Experiences At Historically White Institutions In The United States, Christian Barrientos

All Dissertations

This qualitative research study will illustrate the link(s) between Multiracial students and their perceptions of campus climate at historically White institutions and how that impacts their sense of belonging. Existing bodies of literature and research have focused more extensively on monoracial students of color than Multiracial students. As a result, there is a formidable gap in the literature about how Multiracial students navigate their racial identity at historically White institutions and how multiracial students perceive campus climate based on their experienced sense of belonging. The use of Kellogg and Liddell (2012) will serve as a guide for this research study. …

Some Experiments In Additive Number Theory, Yunan Wang

All Dissertations

This dissertation explores fundamental conjectures in number theory, focusing on the distribution patterns of representation functions in prime pairs. The work concentrates on twin primes, cousin primes, and primes separated by six units, offering a fresh heuristic interpretation of the Hardy-Littlewood correction factor. The analysis progresses to investigate the partition function for prime pairs in the form $(p, p+k)$, specifically for $k = 2, 4, 6$. The study culminates in the derivation of a general formula for prime pairs $(p, p+d)$, where $d$ is an even integer. Drawing on the insights gleaned from examining the correction factor, this dissertation proposes …

Essays In Industrial Organization And Regulation, Micah D. Thomas

All Dissertations

This dissertation is comprised of two essays; in the first, I develop a model to show that when there is a sufficiently large segment of uninformed consumers and an existing norm regarding the advertising of bundled good prices that price obfuscation through base good advertisements can be both: (1) profit maximizing, and (2) result in an equilibrium where only some firms obfuscate. I provide the first empirical evidence of this setting by estimating the increase in prices charged by retail gasoline stations, finding a statistically and economically significant obfuscating premium of 5-7 cents per gallon. I also provide evidence of …

8th Circuit Panel Vacates Preliminary Injunction Against Iowa Lgbtq School Censorship Law, Arthur S. Leonard

Other Publications

No abstract provided.

9th Circuit Panel Affirms Dismissal Of Constitutional Challenge To Title Ix Religious Institution Exemption Provision And Regulations, Arthur S. Leonard

Other Publications

No abstract provided.

Automatic Uncovering Of Patient Primary Concerns In Portal Messages Using A Fusion Framework Of Pretrained Language Models, Yang Ren, Yuqi Wu, Jungwei W. Fan, Aditya Khurana, Sunyang Fu, Dezhi Wu, Hongfang Liu, Ming Huang

Publications

Objectives: The surge in patient portal messages (PPMs) with increasing needs and workloads for efficient PPM triage in healthcare settings has spurred the exploration of AI-driven solutions to streamline the healthcare workflow processes, ensuring timely responses to patients to satisfy their healthcare needs. However, there has been less focus on isolating and understanding patient primary concerns in PPMs-a practice which holds the potential to yield more nuanced insights and enhances the quality of healthcare delivery and patient-centered care. Materials and Methods: We propose a fusion framework to leverage pretrained language models (LMs) with different language advantages via a Convolution Neural …

High-Dose Intravenous Vitamin C Combined With Docetaxel In Men With Metastatic Castration-Resistant Prostate Cancer: A Randomized Placebo-Controlled Phase Ii Trial, Channing Paller, Marianna Zahurak, Adel Mandl, Nicole Metri, Aliya Lalji, Elisabeth Heath, William Kelly, Christopher Hoimes, Pedro Barata, Jason Taksey, Dominique Garrison, Kartick Patra, Ginger Milne, Nicole Anders, Julie Nauroth, Jennifer Durham, Catherine Marshall, Mark Markowski, Mario Eisenberger, Emmanuel Antonarakis, Michael Carducci, Samuel Denmeade, Mark Levine

Department of Medicine Faculty Papers

UNLABELLED: High-dose intravenous vitamin C (HDIVC) administered to produce pharmacologic concentrations shows promise in preclinical models and small clinical trials, but larger prospective randomized trials are lacking. We evaluated the clinical benefit of combining HDIVC with docetaxel in patients with progressive metastatic castration-resistant prostate cancer (mCRPC). In this double-blind, placebo-controlled phase II trial, 47 patients were randomized 2:1 to receive docetaxel (75 mg/m2 i.v.) with either HDIVC (1 g/kg) or placebo. Coprimary endpoints were PSA50 response and adverse event rates. Secondary endpoints included overall survival, radiographic progression-free survival, and quality of life measured using the Functional Assessment of Cancer Therapy-Prostate …

Moral Disengagement And The Tendency To Engage In Academic Dishonesty In Prelicensure Nursing Students, Sarah Guimaraes

Electronic Theses and Dissertations

Despite decades of research, academic dishonesty remains a significant concern in nursing education. The connection of academic dishonesty to dishonest clinical practice presents a moral imperative for nurse researchers to find new facets of understanding these phenomena. Literature regarding moral disengagement in health care is minimal and is even less prevalent in the context of nursing education. The purpose of this study was to determine the effects of moral disengagement on prelicensure nursing students’ tendencies to engage in academic dishonesty in their last or next to last semester of a nursing program. A correlational design via survey method was used. …

Racial Discrimination Increases The Risk For Nonremitting Posttraumatic Stress Disorder Symptoms In Traumatically Injured Black Individuals Living In The United States, Lucas Torres, Timothy J. Geier, Carissa W. Tomas, Claire M. Bird, Sydney Clare Timmer-Murillo, Christine L. Larson, Terri A. Deroon-Cassini

Psychology Faculty Research and Publications

Traumatic, life-threatening events are experienced commonly among the general U.S. population, yet Black individuals in the United States (i.e., Black Americans) exhibit higher prevalence rates of posttraumatic stress disorder (PTSD) and more severe symptoms than other populations. Although empirical research has noted a range of symptom patterns that follow traumatic injury, minimal work has examined the role of racial discrimination in relation to PTSD symptom trajectories. The current study assessed racial discrimination and PTSD symptom trajectories at 6 months postinjury across two separate samples of traumatically injured Black Americans (i.e. emergency department (ED)–discharged and hospitalized). Identified PTSD symptom trajectories largely …

Complement C3ar Signaling: Immune And Metabolic Modulation And Its Impact On Alzheimer’S Disease, Manasee Gedam, Hui Zheng

Center on Aging Staff Publications

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia among the elderly population. Despite its widespread prevalence, our comprehension of the intricate mechanisms governing the pathogenesis of the disease remains incomplete, posing a challenge for the development of efficient therapies. Pathologically characterized by the presence of amyloid β plaques and neurofibrillary tau tangles, AD is also accompanied by the hyperactivation of glial cells and the immune system. The complement cascade, the evolutionarily conserved innate immune pathway, has emerged as a significant contributor to AD. This review focuses on one of the complement components, the …

Sequential Inhibition Of Parp And Bet As A Rational Therapeutic Strategy For Glioblastoma, Shengfan Huang, Shan Zhu, Haiwang Gao, Zixiang Yu, Xiaotong Yan, Zhennan Tao, Yuxiang Dai, Zhe Zhang, Xi Chen, Feng Wang, Francois X Claret, Moshe Elkabets, Ning Ji, Yuxu Zhong, Dexin Kong

Faculty, Staff and Student Publications

PARP inhibitors (PARPi) hold substantial promise in treating glioblastoma (GBM). However, the adverse effects have restricted their broad application. Through unbiased transcriptomic and proteomic sequencing, it is discovered that the BET inhibitor (BETi) Birabresib profoundly alters the processes of DNA replication and cell cycle progression in GBM cells, beyond the previously reported impact of BET inhibition on homologous recombination repair. Through in vitro experiments using established GBM cell lines and patient-derived primary GBM cells, as well as in vivo orthotopic transplantation tumor experiments in zebrafish and nude mice, it is demonstrated that the concurrent administration of PARPi and BETi can …

Automatic Uncovering Of Patient Primary Concerns In Portal Messages Using A Fusion Framework Of Pretrained Language Modelsautomatic Uncovering Of Patient Primary Concerns In Portal Messages Using A Fusion Framework Of Pretrained Language Models, Sunyang Fu, Dezhi Wu, Hongfang Liu, Ming Huang

Faculty, Staff and Student Publications

OBJECTIVES: The surge in patient portal messages (PPMs) with increasing needs and workloads for efficient PPM triage in healthcare settings has spurred the exploration of AI-driven solutions to streamline the healthcare workflow processes, ensuring timely responses to patients to satisfy their healthcare needs. However, there has been less focus on isolating and understanding patient primary concerns in PPMs-a practice which holds the potential to yield more nuanced insights and enhances the quality of healthcare delivery and patient-centered care.

MATERIALS AND METHODS: We propose a fusion framework to leverage pretrained language models (LMs) with different language advantages via a Convolution Neural …

Artificial Intelligence In Fusion Protein Three-Dimensional Structure Prediction: Review And Perspective

Faculty, Staff and Student Publications

Recent advancements in artificial intelligence (AI) have accelerated the prediction of unknown protein structures. However, accurately predicting the three-dimensional (3D) structures of fusion proteins remains a difficult task because the current AI-based protein structure predictions are focused on the WT proteins rather than on the newly fused proteins in nature. Following the central dogma of biology, fusion proteins are translated from fusion transcripts, which are made by transcribing the fusion genes between two different loci through the chromosomal rearrangements in cancer. Accurately predicting the 3D structures of fusion proteins is important for understanding the functional roles and mechanisms of action …

Patient-Centered Clinical Decision Support Challenges And Opportunities Identified From Workflow Execution Models, Nicole A Gauthreaux, James Swiger, Edwin A Lomotan, Prashila Dullabh

Faculty, Staff and Student Publications

OBJECTIVE: To use workflow execution models to highlight new considerations for patient-centered clinical decision support policies (PC CDS), processes, procedures, technology, and expertise required to support new workflows.

METHODS: To generate and refine models, we used (1) targeted literature reviews; (2) key informant interviews with 6 external PC CDS experts; (3) model refinement based on authors' experience; and (4) validation of the models by a 26-member steering committee.

RESULTS AND DISCUSSION: We identified 7 major issues that provide significant challenges and opportunities for healthcare systems, researchers, administrators, and health IT and app developers. Overcoming these challenges presents opportunities for new …

Interagency Collaboration And The School-To-Prison Pipeline: Perspectives Of Public High School And Juvenile Detention Facility Administrators, Michael A. Allen Ii

Education Doctoral

The academic plight of Black and brown youth who enter the United States juvenile justice system is well-documented. Their likelihood of graduating from high school decreases, while the likelihood of dropping out and being further involved with the justice system increases. Although many factors contribute to this conundrum, this study explored the relationship between the public education system and the juvenile justice system. Using an adaptive leadership theoretical framework, this transcendental phenomenological study sought to ascertain the perspectives of administrators working in public high schools as well as those working in juvenile detention facilities across New York State. Through semi-structured, …

2024 August, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for August of 2024.

Digitally Connected, Evolutionarily Wired: An Evolutionary Mismatch Perspective On Digital Work, Mark Van Vugt, Stephen M. Colarelli, Norman P. Li

Research Collection School of Social Sciences

This paper makes the case for an evolutionary mismatch between digital work and the way human ancestors engaged in work. Psychological adaptations for producing things that early humans needed to survive and thrive, such as cognitive mechanisms for obtaining and processing food, toolmaking, and learning valuable working skills, evolved in the context of small networks of hunter–gatherers. These adaptations are central to understanding the significance of work in human evolution. Evolutionary mismatches operate when novel environments cue ancestral adaptations in ways that no longer provide adaptive benefits. We argue that digital work, although efficient and productive, is misaligned with some …

Factors Impacting Treatment Decisions In Caregivers Of Autistic Children, Tiffany Harris

Dissertations

Caregivers of autistic children are not only tasked with deciding upon various treatment options for their children’s symptoms but must also navigate the initial crisis that is experienced after receiving a diagnosis of ASD for their children (Blancher, 1984; Ellis, 1989). Leventhal’s Common Sense Model of Self-Regulation (the CSM; Leventhal et al., 1980) is a theoretical framework developed to understand the self-regulatory processes involved in adapting to and managing health threats and posits that cognitive and emotional illness perceptions influence illness outcomes through coping behaviors. This is the first study to examine all major components of the CSM (i.e., cognitive …

Elucidation Of Molecular Mechanisms Underlying Tumor Necrosis Factor (Tnf) Release From Mast Cells, Tolulope Eunice Ayo

Dissertations

Mast cells are one of the major producers of tumor necrosis factor-alpha (TNF), and mast cell-derived TNF (MC-TNF) is associated with pathological conditions such as rheumatoid arthritis, inflammatory bowel diseases, and allergic asthma. However, the molecular machinery underlying TNF release from mast cells has been unclear, despite the conserved nature of exocytosis. To delineate the exocytic machinery required for TNF release from mast cells, we systematically dissected the exocytic fusion machinery (e.g., Munc13, Munc18, and VAMP families) expressed in mast cells, using a combination of CRISPR-dependent knockout, RNA interference, confocal microscopy, lentiviral rescue experiments, and cell-based assays. Out of the …

Evaluation Of Roadway Reconfigurations In Louisville, Kentucky, William Staats, Adam Kirk

Kentucky Transportation Center Research Report

In 2009, Louisville Metro Public Works undertook its first roadway reconfiguration project, converting a section of Eastern Parkway (US 60A) from a four-lane undivided road to a three-lane section with a two-way left-turn lane and one travel lane in each direction. Since this initial project, Louisville Metro Public Works and the Kentucky Transportation Cabinet (KYTC) have completed 40 roadway reconfigurations to reduce the number of through lanes and reassign existing right-of-way to other roadway users. Additionally, the agencies have 25 more planned or proposed reconfiguration projects. This report documents the safety and operational performance of reconfigured roads. Across all projects, …