Digital Commons Network^™

Sars-Cov-2 Neurotropism: Understanding Effects At The Blood-Brain Barrier And Hematogenous Neuroinvasiveness, Taylor E. Martinez

USF Tampa Graduate Theses and Dissertations

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, has provisional counts of over 110 million documented cases and 1.218 million deaths (as of February 2024) in the United States since January 2020. SARS-CoV-2 is an airborne respiratory virus that primarily infects the lungs via the ACE2 receptor but has well-documented secondary target organs including the kidneys, the gastrointestinal tract, the heart, and the skin. SARS-CoV-2 also infects the brain, but the hematogenous route of viral entry to brain is still not fully characterized. Understanding how SARS-CoV-2 traverses the blood-brain barrier (BBB) as well as how it …

Admission And Discharge Practices Among Assisted Living Communities: The Role Of State Regulations And Organizational Characteristics, Cassandra L. Hua, Lindsey Smith, Sheryl Zimmerman, Gauri Gadkari, Paula Carder, Philip D. Sloane, Christopher J. Wretman, Kali S. Thomas

Institute on Aging Publications

A better understanding of factors associated with assisted living admission and discharge practices can help identify communities that are more likely to allow residents to age in place. This study examined how state regulations and assisted living organizational characteristics relate to community admission and discharge practices for bathing, getting out of bed, and feeding.

Navigating The Nexus: Competition Law, Data Privacy, And Regulatory Challenges In The Digital Economy, Aalaa Tarek El Gohary

Theses and Dissertations

Competition law and data privacy meet at a crucial point in the growing digital economy, making it essential to delve into their intricate relationship. This thesis investigates how competition law and data protection law interact within the digital market. It examines how data protection regulations influence market dynamics and competition, and how competition law affects data processing and individual rights during the digital transformation. By thoroughly exploring key themes, such as historical context, current challenges, and regulatory responses, this research aims to shed light on the changing regulatory landscape and its impact on future frameworks in the digital era. The …

High And Low: Abortion In The Press In The Late Nineteenth Century And Early Twentieth Century, Lawrence M. Friedman, Hutchinson Fann

Cleveland State Law Review

This Article analyzes the newspaper coverage of abortion in the late nineteenth century and early twentieth century. While coverage of abortion was spotty before the Civil War, we find that a great many articles on abortion appeared after 1850 and for the rest of the century. But by the early twentieth century, although abortion remained a common practice, newspaper coverage of the issue shrank almost to nothing. We examine why this rise and fall in abortion coverage occurred, and what these changes in press coverage tell us about the role of abortion in politics and culture.

Contract Law, Equality And The State, Orit Gan

Cleveland State Law Review

There is a rich and diverse literature on contract law and equality, discussing whether contract law should advance social equality and if so how should contract law achieve that. However, this literature has yet to address the State’s role in combating social inequality through contract law. Filling this void this Article discusses three strategies the State can and should adopt in promoting social equality, by enforcing contracts, applying contract law doctrines, and regulating and legislating laws as background rules. After mapping these three state powers the Article further explores three test cases: enforcing nonmarital agreements, applying contract defenses in consumer …

Courting Oblivion Part I: How To Predicate An Act Of Oblivion On The Right To Move On, Joshua J. Schroeder

Cleveland State Law Review

This is the opener of the three-part Courting Oblivion series on the legal concept of oblivion, meaning legal forgetfulness, letting go of the past, or forgiveness, usually to predicate a second chance, a restart, or even an era of reconstruction. This Article opens the Courting Oblivion series by demonstrating how blind-deaf concepts of justice are fundamentally ignorant of the rights and powers of oblivion. The series’ second and third parts will explain more about how acts of oblivion can secure governmental legitimacy and why oblivion needs to be enacted for whistleblowers generally.

This Article defines the legal concept of oblivion …

Washington V. Glucksberg’S Original Meaning, Marc Spindelman

Cleveland State Law Review

This Article elaborates and defends Washington v. Glucksberg’s original meaning both on its own terms and against accounts of Glucksberg that depict it as having announced and followed a strict test of history and tradition as its basic approach to Fourteenth Amendment substantive due process rights.

The nominal occasion for the present return to Glucksberg and its original meaning is the Supreme Court’s decision in Dobbs v. Jackson Women’s Health Organization. Dobbs famously insists that Glucksberg supplies it with the authoritative grounds in the Court’s Fourteenth Amendment substantive due process jurisprudence for its own history-and-tradition-based approach to Roe v. …

Missed Exits: Causal Mechanisms Influencing Militarized Interstate Dispute Escalation In Latin America, Colton Arciniaga

Undergraduate Theses, Capstones, and Recitals

Research on militarized interstate disputes (MIDs) and the reasons for their escalation to interstate war is sparse at the global level and the regional level in Latin America. This thesis contributes new research on militarized interstate dispute escalation in Latin America. In this project, I ask: how do differences in conflict escalation indicators between states affect whether a Latin American country will participate in a Militarized Interstate Dispute that escalates to the use of force? To answer this question, I conduct a case study utilizing the most similar cases analysis approach to compare the cases of the 1995 MID between …

Axion Dark Matter With Not Quite Black Hole Domination, Ufuk Aydemi̇r

Turkish Journal of Physics

No abstract provided.

#Disgusted: Identifying Potential Sub-Factors Of Moral Disgust Through Reflexive Thematic Analysis Of Tweets, Ryan Statton, Alison Bacon, Jaysan Charlesford, Sylvia Terbeck

School of Psychology

Social media provides an untapped resource for exploring Moral Disgust. We therefore drew on ‘tweets’ about Moral Disgust (k=526) to better conceptualise the situations, people, and concepts users found Disgusting. Our Reflexive Thematic Analysis identified two themes and accompanying subthemes: Hierarchical Disgust and Third-Party Disgust. Hierarchical Disgust was constructed from expressions of Disgust directed to power structures, abuses of power, and leaders, whereas Third-Party Disgust comprised expressions directed at negative outcomes for others, often in the form of discrimination or harm. Both themes served as a form of group protection through out-group distancing and normative in-group policing. Importantly, this research …

Development Of Biochemical And Cellular Probes To Study Ripk1 Target Engagement, Xin Yu, Hanfeng Lin, Feng Li, Jin Wang, Dong Lu

Faculty, Staff and Students Publications

RIPK1 inhibitors have emerged as promising candidates for treating diverse diseases, including inflammatory diseases, autoimmune disorders, Alzheimer’s disease, and cancer. However, the previously reported binding assays have limited sensitivity and stability, impeding high-throughput screening and robust characterization of the RIPK1 inhibitors. To address this challenge, we introduced two probes, T2-BDP-FL and T3-BDP-FL, derived from distinct RIPK1 inhibitors with different binding modes to establish time-resolved fluorescence resonance energy transfer (TR-FRET) displacement assays. Employing our TR-FRET displacement assays, we quantified the biochemical binding affinities of a series of RIPK1 inhibitors with diverse structural and binding modes for human RIPK1. Consistent results were …

Ikzf1 And Ubr4 Gene Variants Drive Autoimmunity And Th2 Polarization In Igg4-Related Disease, Qingxiang Liu, Yanyan Zheng, Ines Sturmlechner, Abhinav Jain, Maryam Own, Qiankun Yang, Huimin Zhang, Filippo Pinto E Vairo, Karen Cerosaletti, Jane H Buckner, Kenneth J Warrington, Matthew J Koster, Cornelia M Weyand, Jörg J Goronzy

Faculty, Staff and Student Publications

IgG4-related disease (IgG4-RD) is a systemic immune-mediated fibroinflammatory disease whose pathomechanisms remain poorly understood. Here, we identified gene variants in familial IgG4-RD and determined their functional consequences. All 3 affected members of the family shared variants of the transcription factor IKAROS, encoded by IKZF1, and the E3 ubiquitin ligase UBR4. The IKAROS variant increased binding to the FYN promoter, resulting in higher transcription of FYN in T cells. The UBR4 variant prevented the lysosomal degradation of the phosphatase CD45. In the presence of elevated FYN, CD45 functioned as a positive regulatory loop, lowering the threshold for T cell activation. Consequently, …

An Analysis Of A Pilot Program: Oral Fluid Testing Of Drugged Drivers In Michigan, Amber L. Libby

Walden Dissertations and Doctoral Studies

Law enforcement officers are charged with the responsibility of interpreting complicated social situations of the public every day. Adding difficulty is rapid cannabis legalization across the United States, including Michigan; encompassed in medicinal legalization in 2008 and recreational legalization in 2018, which has brought with it many changes, affecting economic, social, safety, and criminal elements. Michigan has seen an approximate 45% increase in traffic crashes with drivers who tested positive for cannabis over a five-year time frame (2013 – 2018). The purpose of this quantitative correlational study was to determine the accuracy of roadside oral fluid testing introduced in Michigan …

Strategies For Human Capital Development In An Oil And Gas Organization, David Ebamije Akpieyi

Walden Dissertations and Doctoral Studies

Some oil and gas (O&G) leaders lack strategies to promote human capital development (HCD) training to increase employees’ productivity in their organizations, impacting their overall productivity. Therefore, O&G organizational leaders need to take deliberate steps to monitor and improve their human capital productivity continuously. Grounded in human capital theory, the purpose of this qualitative pragmatic inquiry was to explore strategies O&G leaders use to promote HCD training. The participants comprised six business leaders from O&G multinational organizations who successfully implemented strategies to promote HCD training to increase employees’ productivity. Data were collected using semistructured interviews and analyzed through thematic analysis. …

An Analysis Of A Pilot Program: Oral Fluid Testing Of Drugged Drivers In Michigan, Amber L. Libby

Walden Dissertations and Doctoral Studies

Law enforcement officers are charged with the responsibility of interpreting complicated social situations of the public every day. Adding difficulty is rapid cannabis legalization across the United States, including Michigan; encompassed in medicinal legalization in 2008 and recreational legalization in 2018, which has brought with it many changes, affecting economic, social, safety, and criminal elements. Michigan has seen an approximate 45% increase in traffic crashes with drivers who tested positive for cannabis over a five-year time frame (2013 – 2018). The purpose of this quantitative correlational study was to determine the accuracy of roadside oral fluid testing introduced in Michigan …

Strategies For Human Capital Development In An Oil And Gas Organization, David Ebamije Akpieyi

Walden Dissertations and Doctoral Studies

Some oil and gas (O&G) leaders lack strategies to promote human capital development (HCD) training to increase employees’ productivity in their organizations, impacting their overall productivity. Therefore, O&G organizational leaders need to take deliberate steps to monitor and improve their human capital productivity continuously. Grounded in human capital theory, the purpose of this qualitative pragmatic inquiry was to explore strategies O&G leaders use to promote HCD training. The participants comprised six business leaders from O&G multinational organizations who successfully implemented strategies to promote HCD training to increase employees’ productivity. Data were collected using semistructured interviews and analyzed through thematic analysis. …

An Investigation Of Quaternary Metal Chalcogenide Semiconductors Possessing Intrinsically Low Thermal Conductivity, Oluwagbemiga P. Ojo

USF Tampa Graduate Theses and Dissertations

Inorganic materials with unique physical properties are vital components of modern technology, from electronic devices to energy storage and conversion systems. Recent advancements in materials research and development have garnered significant interest, particularly in the realm of sustainable energy applications like thermoelectrics and photovoltaics. The development of novel materials with enhanced electronic and thermal properties has emerged as a focal point in advancing these critical applications. Furthermore, low thermal conductivity materials are sought after for technologically significant applications such as thermal barrier coatings, rewriteable data storage utilizing phase change materials and thermoelectrics. However, the current efficiency levels of materials used …

Redefining Arctic Boundaries In A Changing Climate: Interdisciplinary Perspectives On Governance Strategies, Llucia Mascorda-Cabre

School of Biological and Marine Sciences

The Arctic rapidly transforms due to global warming and increased human activities, triggering complex changes at unprecedented speeds that challenge conventional institutional responses. We analyse these changes through the lenses of social, political, and environmental boundaries and investigate their impacts on both inhabitants' livelihoods and the region's political framework. Employing an interdisciplinary approach, we highlight the complexities of understanding the interplay among global, regional, and local dynamics in an era where human and non-human aspects are entwined. Our analysis concentrates on three areas: definition of the Arctic; legal disputes concerning the waters around the Svalbard Archipelago; evolving natural hazards and …

2024-06-13 Emails From The Non-Tenure Track Ad Hoc Committee, Morehead State University. Faculty Senate.

Faculty Senate Records

Emails from the Non-Tenure Track Ad Hoc Committee and Faculty Senate President from June 6 to June 13, 2024.

Neuroinflammation And Gut Barrier Function Post Traumatic Brain Injury, Anne Sullivan

Master's Theses

Traumatic Brain Injury (TBI) is a major cause of morbidity and mortality that afflicts millions of people in the United States annually. TBI mice had significantly increased expression of the pro-inflammatory cytokines and decreased expression of tight junction proteins CLDN5, CLDN12, and OCLD in brain lesion tissue. TBI mice exhibited a significant accumulation of FITC in the middle and distal part of the small intestine compared to sham mice. TBI mice exhibited an increase in pathogenic bacteria Enterobacteriaceae and a decrease in beneficial bacteria lactobacillus. TBI mice exhibited a trend toward an increase in permeability compared to no treatment. These …

Around The Center, 1992 February, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Around the Center", an employee newsletter. This issue has staffing and departmental updates, patient letters, and features on the hospital's food production team and on drunk driving.

واقع حريّة الرأيّ والتعبير عبر الإنترنت (دراسة حالة الأردن), Oraib Hani Momani

Journal of the Association of Arab Universities for Research in Higher Education مجلة اتحاد الجامعات العربية للبحوث في التعليم العالي

هدف المقال استعراض واقع حريّة الرأي والتعبير عبر الانترنت في الأردن. ولتحقيق هذا الهدف. تم استخدام المنهج الوصفي التحليلي، والمنهج القانوني، ومنهج دراسة الحالة. وقد توصّلت الدراسة إلى أن حريّة الرأي وحريّة التعبير ترتبط بالأخرى وهما انعكاس لبعضهما، إذ إنّ ما يحمله الفرد من أفكار ومعتقدات وآراء ينعكس عمليّاً على أرض الواقع من خلال ممارسته لحقّه في التعبير. وما يُميّز الحق في حريّة الرأي والتعبير عبر الإنترنت هو أنّه تتم ممارسته في البيئة الرقميّة، وذلك إمّا من خلال تلقّي الأفكار أو المعتقدات أو الآراء عبر الشبكة العنكبوتيّة، أو التعبير عن الأفكار أو الآراء أو المعتقدات التي يحملها الفرد بأيّ وسيلةٍ …

ضمانات المتهم في مرحلة التحقيق الأولي وفق التشريع الأردني, Qusai Mahmoud Seliman Al Qutishat

Journal of the Association of Arab Universities for Research in Higher Education مجلة اتحاد الجامعات العربية للبحوث في التعليم العالي

هدف المقال التعرف على ضمانات المتهم في مرحلة التحقيق الأولي وفق التشريع الأردني، وبينت المقصود بالمتهم وشروطه والفرق بين المتهم والمشتبه به والظنين، ومفهوم التحقيق الأولي وأهميته واختلافه عن التحقيق الابتدائي، وماهي مهام واختصاصات الضابطة العدلية وفق التشريع الأردني، وتوضيح ضمانات المتهم في مرحلة التحقيق الأولي وفق التشريع الأردني. وخلصت الدراسة إلى نتائج عدة منها أنه يجوز لأفراد الأمن العام القيام بالطرق المشروعة بأي عمل من شأنه جمع المعلومات والإيضاحات وجمع الأدلة المثبتة لوقوع الجريمة ونسبتها إلى فاعلها، وأن ضمانات المتهم وسائل منحها القانون كحماية للمشتكى عليه من أي اعتداء أو ضرر يهدده، سواء في جسده أو حياته الخاصة أو …

Factors Associated With Digestive System Cancer Screening In Texas., Stella Green

Walden Dissertations and Doctoral Studies

Walden University College of Health Sciences and Public Policy This is to certify that the doctoral study by Stella Green has been found to be complete and satisfactory in all respects, and that any and all revisions required by the review committee have been made. Review Committee Dr. Shanna Barnett, Committee Chairperson, Public Health Faculty Dr. Simone Salandy, Committee Member, Public Health Faculty Chief Academic Officer and Provost Sue Subocz, Ph.D. Walden University 2024 The specific research problem in this study was that despite the high prevalence of digestive system cancer, screening for digestive system cancer has not been optimized, …

Factors Associated With Digestive System Cancer Screening In Texas., Stella Green

Walden Dissertations and Doctoral Studies

The specific research problem in this study was that despite the high prevalence of digestive system cancer, screening for digestive system cancer has not been optimized, thus compromising early diagnosis and treatment. Early detection and treatment of digestive system cancer can generate better patient outcomes and enhance quality of life. The purpose of this quantitative correlation study guided by the social ecological model was to examine whether demographic factors (age, sex, race/ethnicity, marital status), socioeconomic status (education level, employment status, income level), and health behaviors (physical activity, tobacco use, healthcare coverage) are associated with receiving digestive cancer screening in Texas. …

A Trna Modification Pattern That Facilitates Interpretation Of The Genetic Code, Isao Masuda, Ya-Ming Hou

Department of Biochemistry and Molecular Biology Faculty Papers

Interpretation of the genetic code from triplets of nucleotides to amino acids is fundamental to life. This interpretation is achieved by cellular tRNAs, each reading a triplet codon through its complementary anticodon (positions 34–36) while delivering the amino acid charged to its 3′-end. This amino acid is then incorporated into the growing polypeptide chain during protein synthesis on the ribosome. The quality and versatility of the interpretation is ensured not only by the codon-anticodon pairing, but also by the post-transcriptional modifications at positions 34 and 37 of each tRNA, corresponding to the wobble nucleotide at the first position of the …

Woosah! Minoritized Student Affairs Professionals: Navigating Racial Battle Fatigue At A Predominately White Institution, Julius J. Grayson

Theses and Dissertations

Using an interpretative phenomenological analysis this study explored the rich experiences of seven racially minoritized student affairs professionals (RMSAPs) who experienced racial battle fatigue (RBF) and the impact it had on their health at a predominantly white institution (PWI). Social psychological research has identified both blatant and subtle forms of racial discrimination have adverse which lead to deleterious mental health outcomes for racially minoritized individuals. The findings indicated that these racially minoritized student affairs professionals were experiencing racial microaggressions and racial battle fatigue at their predominately white institution. In order to reclaim their wellness, participants shared the strategies they used …

Exploring Culturally Responsive Instruction In Advanced Placement Science: Perspectives From Teachers Of Underrepresented Students, Nathan Frey

Theses and Dissertations

The study investigated teacher perceptions on the influence of culturally responsive instruction in advanced placement (AP) science courses, focusing on teachers of underrepresented student populations. The study explored how teachers viewed these educational strategies to support diverse student groups and bridge opportunity gaps prevalent in AP science education. Through narrative analysis, the research considered teachers' perceptions and implementations of culturally responsive practices and the engagement of underrepresented students in AP science. This exploration interpreted the potential of culturally responsive pedagogy to enhance student outcomes, participation, and interest in science, contributing to a more equitable and inclusive AP science experience while …

Usa V. Yaroslav Churuk

2024 Decisions

USDC for the Eastern District of Pennsylvania

Usa V. Robert Brown

2024 Decisions

USDC for the Middle District of Pennsylvania