Digital Commons Network^™

Artificial Intelligence In Pharmaceutical Care: Transforming Drug Discovery, Development, And Patient-Care Delivery, Abdulrahman G. Alharbi, Abdulrahman A. Aljabri

Saudi Medical Journal

The integration of artificial intelligence (AI) into pharmaceutical care represents a paradigm shift in healthcare delivery, offering unprecedented opportunities to revolutionize medication management, accelerate drug development, and enhance patient outcomes. This comprehensive review synthesized evidence from global literature (2021–2025) examining AI applications across drug discovery and development, clinical trials optimization, medication therapy management, and pharmacy operations. The AI demonstrated prediction accuracies of 86–98% in drug discovery, 80% improvement in clinical trial recruitment efficiency, and 32.7% increase in medication adherence over standard care. The global AI drug discovery market, valued at \$1.5 billion (2023), is projected to reach \$11.8 billion by …

Healthcare-Associated Infection Causes And Mitigation Strategies: A Systematic Review, Mohammad Irfan, Nahed Alquwez

Saudi Medical Journal

Objective: To describe the landscape of healthcare-associated infections (HAI) and, in particular, to pay attention to the types of infection that are usually seen, the most common infectious agents involved and the effective prevention strategies. Methods: A detailed search was performed using Google and PubMed, and studies that exclusively addressed healthcare associated infections or their mitigation. Studies published since 2000 were included. Data from individual articles were extracted and categorized by study focus, type of infection, causes and contributing factors, and documented mitigation strategies. Editorials, reviews, case studies, meta-analyses, and systematic reviews were excluded. Results: The analysis showed that infections …

Dual-Pathway System For Low-Latency Pii Redaction In Generative Image Modification, Mira Leung

Defensive Publications Series

Some personally identifiable information (PII) redaction methods for generative image applications can have high latency and computational costs, which may limit their use in interactive contexts. A dual-pathway architecture may be used to process image modification requests. A synchronous, low-latency pathway can detect and obfuscate potential PII before a generative model concurrently inpaints the obfuscated areas and applies user modifications. Simultaneously, an asynchronous, offline pathway can generate a more thoroughly redacted version of the source image and store it for future use. This hybrid approach can provide a low-latency response suitable for on-demand image generation, while progressively creating higher-quality redacted …

The Role Of The Nlrp3 Inflammasome In Preeclampsia And Implantation Failure: A Molecular Review, Ari Budi Suryawinata, Mariel Tania Darmayani, Listyani Suhargo

Chulalongkorn Medical Journal

The NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a critical multiprotein complex of the innate immune system that functions as a molecular sensor for a wide array of danger signals. While its activation is essential for host defense and tissue homeostasis, its dysregulation is increasingly implicated in the pathophysiology of numerous inflammatory disorders. This review article synthesizes the current molecular understanding of the NLRP3 inflammasome, focusing on its dual role in health and disease. We first provide a concise overview of the canonical two-step mechanism of NLRP3 activation and the intricate molecular checkpoints including genetic factors, post-translational …

A Person For All Seasons: The Remarkable Leadership Of Mother Cabrini And Why It Matters Today, Emilio F. Iodice

The Journal of Values-Based Leadership

The history of organizational management is often written in the bold, sweeping strokes of industrial barons or the calculated maneuvers of political statesmen. Yet at the turn of the twentieth century, one of the most sophisticated examples of global institutional scaling was orchestrated by a woman who stood barely five feet tall, held no formal political title, and suffered from debilitating physical frailty. Frances Xavier Cabrini (1850–1917) did not merely practice charity; she engineered a global revolution of care. Over a twenty-eight-year executive career, she founded sixty-seven schools, orphanages, and hospitals across three continents, thereby transforming the social landscape of …

The Ethical Shadow: A Jungian Inquiry Into The Paradoxes Of Authentic Leadership, S. Eissa Hashemi

The Journal of Values-Based Leadership

This paper examines the “authenticity paradox” in leadership through the lens of Jungian psychology, moving beyond traditional behavioral frameworks to explore the depth of the leader’s psyche. Drawing on Shaw’s (2023) pillars of authenticity — self, followers, and context — the study investigates how leaders navigate conflicting existential and relational demands. By utilizing the concept of individuation, the paper analyzes the tension between the “unified self” and the “fluid self,” particularly as it relates to Mostafa Malekian’s (2021) five dimensions of self-alignment. The research highlights a “central clash” within the cultural context, where collective archetypes and cultural complexes impose idealized …

The Philosophical Aspect Of Spirituality And Entrepreneurial Leadership In The Indian Knowledge System, Nidhi Kaushal

The Journal of Values-Based Leadership

Entrepreneurs have an obligation to conserve their literature, art, and culture in any format because it helps to fortify their cultural heritage and memories. In the context of entrepreneurship, a useful and insightful examination of the ancient Indian knowledge framework has proposed the growth of culture-based enterprises, which reflects the magnificent integration of human values with traditional wisdom-based work ethics. The nature of today's modern entrepreneurship is an adjusted specification based on innovative context, which is different from the ancient fundamental policies and practices. This study introduces cultural entrepreneurship and its originality through the traditional and indigenous art and skill …

Moral Identity, Joseph P. Hester

The Journal of Values-Based Leadership

Foundationally, our communal awareness offers a complexity of meaning, but don’t be deterred, it also provides an avenue for understanding ethics, suggesting a definition of “humanity” as “community.”

Ethics: The Connective Tissue Of Human Life, Joseph P. Hester

The Journal of Values-Based Leadership

America needs to take a deep breath and reconsider the purposes of democracy, but more, infuse some modicum of commonsense into political decision-making. How many unnecessary wars and homeland killings must we endure and how many lies must we listen to as Trump filibusters his way onto the world’s stage? Seeking lucidity in Trump’s actions may be a stretch and even many of his supporters are asking for explanations, values’ consistency, and Constitutional clarity. I could go on, but this comment sets the tone for this editorial comment.

Summer/Fall 2026

The Journal of Values-Based Leadership

No abstract provided.

Report Of The Ada Delegation, M. Joan Gillespie Dds

Virginia Dental Journal

No abstract provided.

Board Of Directors Actions In Brief - November 11, 2011

Virginia Dental Journal

No abstract provided.

State And Federal Poster Requirements, Garland Gentry Dds

Virginia Dental Journal

No abstract provided.

Advanced Hybrid-Green Ultrasound–Infrared–Microwave Trifolium Repens Essential Oil Isolation With Multi-Target Ethnomedicine Bioactivity Against Neuropathy, Inflammation And Multidrug-Resistant Infection, Sara Al Ayoubi, Ibrahim Abdelwahab, Maha Aboul-Ela, Abdalla El- Lakany, Karim Raafat

Journal of Food and Drug Analysis

Trifolium repens (white clover) is rich in bioactive volatiles with therapeutic potential. This study developed an advanced hybrid ultrasound–infrared–microwave hydro-distillation (UIMHD) method for efficient essential oil (EO) isolation and investigated its active sesquiterpene, pseudoionone, for multi-mechanistic neuroprotection in diabetic neuropathy (DN). The optimized UIMHD system synergistically combined ultrasound cavitation, infrared heating, and microwave hydro-distillation, enhancing yield and reducing time versus conventional extraction. Gas chromatography–mass spectrometry (GC–MS) profiling identified pseudoionone as the dominant constituent. Pharmacological evaluations were performed in alloxan-induced diabetic mice to assess antidiabetic, anti-inflammatory, neuroprotective, and anticonvulsant activities. Cytokine modulation (TNF-α, IL-6, IL-10), oxidative stress markers (CAT, GSH, TBARS), …

Spatial Distribution: Effect Of Oxygen Availability On Gut Microbiota Adhesion And Colonization, Ruixue Ding, Xiaotong Sun, Yinan Wang, Binbin Tu, Yue Liang, Qi Lin, Fuqiang Zhao

Journal of Food and Drug Analysis

The gut microbiota plays a crucial role in host digestion and immune regulation; however, most existing research relies on fecal sampling, leaving uncertainty regarding whether fecal microbiota can accurately reflect the symbiotic microbial components at distinct gut sites. To address this gap, this study employed 16S rRNA gene sequencing to systematically analyze the microbial composition of three spatial compartments in the rat colon: luminal contents, mucus layer, and epithelial tissue. The results revealed notable differences in microbial communities across the three compartments. The luminal contents, which were closely associated with the fecal microbiota, exhibited high microbial abundance, encompassing gram-positive bacteria, …

The Protective Potential Of Intestinal Bifidobacterium-Derived Extracellular Vesicles With Unique Lipid Composition Against Blue Light-Induced Damage In Retinal Cells, Wei-Hsuan Hsu, Pin-Hsuan Su, Hao-Yuan Chien, Tzu-Ming Pan, Bao-Hong Lee

Journal of Food and Drug Analysis

Bifidobacterium longum is a probiotic that resides in the intestine, and extracellular vesicles (EVs) released by microorganisms have garnered attention in recent years for their role in regulating host health. This study found that triacylglycerol, cholesteryl esters, and free fatty acid (18:0 and 16:0) are primarily composed of lipids in B. longum-derived EVs by lipidomics assay. Such lipid composition facilitates the entry of EVs into ARPE-19 cells and protects the cells from oxidative death induced by blue light exposure. Transcriptomic analysis revealed that treatment with B. longum-derived EVs can regulate phosphoinositide 3-kinase and mTOR, thereby enhancing the survival …

The Evolution Of Desi-Msi: A Comprehensive Look At Preprocessing And Quantification Strategies For Metabolomics, Cheng-Hung Yang, Hung-Yao Ho, Chen-Yu Chang, Mei-Ling Cheng

Journal of Food and Drug Analysis

Mass spectrometry imaging (MSI) has become an indispensable tool in metabolomics for visualizing the spatial distribution of biomolecules within tissues. Due to its direct, ambient analysis capability, desorption electrospray ionization (DESI-MSI) has evolved from a rapid screening tool into a precise and reliable quantitative platform. We delve into its technical principles and particularly review the criticality of sample preprocessing, highlighting the paradigm shift from a "no-preprocessing" approach to one of "optimized preprocessing." The paper details how factors like sample preservation, choice of embedding agents, washing, drying, and on-tissue chemical derivatization all impact data quality. We also discuss how the addition …

An On-Vessel Signal Discrimination Layer For Bandwidth-Constrained Maritime Decision Support, Dev Mohanty

Defensive Publications Series

The DeepBlue protocol sentry is an on-vessel signal-discrimination independent layer that filters high-frequency NMEA telemetry streams into compact, information-dense feature vectors. Unlike AIS broadcasts, rather than transmitting all raw sensor data (which is bandwidth-expensive and mostly redundant), it:

1. Normalizes raw NMEA sentences across GPS, propulsion, environmental sensors
2. Derives features (fuel consumption, course/speed changes, propulsion efficiency drift, loitering detection) over rolling 1-5 min windows
3. Scores materiality — only flags features that deviate from the vessel's own baseline
4. Assembles vectors of tens-to-hundreds bytes for transmission over satellite/mesh uplinks

The key insight: filter redundancy at source before transmission, not downstream. It's a …

System, Method, And Computer Program Product For Processing Documents Into Hierarchical Data Structures For Retrieval-Augmented Generation, Komal Mahto

Defensive Publications Series

ABSTRACT

Systems, methods, and computer program products are provided for processing documents. The system includes at least one processor configured to segment a document into a plurality of segments, construct a hierarchical data structure comprising a plurality of nodes representing the plurality of segments, each node of the plurality of nodes comprising hierarchical metadata, in response to determining at least one first node of the plurality of nodes exceeds a token limit, split the at least one first node into a first subset of nodes based on a semantic analysis of text represented by the at least one first node, …

Loci ∞ — Infinity Memory Middleware With Temporal Compression And Universal Cross-Platform Injection, Arko Sanyal

Defensive Publications Series

We disclose LOCI ∞, a universal memory middleware system for cross-platform AI memory synchronization. LOCI extracts entity knowledge from conversations on any LLM platform, stores it in a user-owned typed dual-stream profile (informational stream: heat-decaying associative entities; quantifiable stream: exact typed facts with zero-hallucination retrieval), and injects relevant context back into any LLM platform at any point during or between sessions. The system implements hardware-aware storage tiering mapped to entity semantic salience scores (VRAM/RAM/NVMe), graph-neighbor heat propagation via spreading activation, generation-time confidence-gated correction, keystroke-level predictive context prewarm, and a privacy-locked population memory layer using federated learning with differential privacy. A …

Touch Input For Passive Fingernail Displays Via Hub-Side Capacitive Sensing Over A Shared Power-And-Data Jewelry Conductor, Benny Goldstein

Defensive Publications Series

A wearable system adds touch input to artificial-fingernail displays while keeping the nail itself passive: no battery, no wireless transceiver, and, in the preferred embodiment, no touch-sensing circuitry on the nail. Each nail unit carries an electronic display and a transparent touch electrode. Operating power and image data reach the nail over a single decorative conductor - fine insulated wire concealed in a hollow jewelry chain - from a body-worn hub, such as a finger ring or bracelet, housing the battery, controller, and Bluetooth radio. The same conductor also carries the touch-sense signal: the hub measures the capacitance of the …

No One’S Child: Regulatory Gaps And The Wellbeing Of High School International Students (Hsis) In Homestays In Ontario, Canada, Patricia Quan

Critical Internationalization Studies Review

No abstract provided.

The Arching Analysis Of Rigid Inclusion System Using Cohesive Fill For Load Transform Platform, Ramy Mohammed Mohammed Khalil, Amr F. Elhakim

HBRC Journal

Rigid Inclusion System (RIS) is one of the economic systems for improving highly compressible soil by increasing the bearing capacity of foundation soil and reducing settlements. This system consists of a load transform platform (LTP) with or without geosynthetic reinforcement (GR) membrane resting on an arrangement of piles. The LTP redistributes the fill embankment load so that a higher percentage of load is transferred to pile by arching that leads to a reduction in the settlement of the foundation soil. Many analytical, numerical and experimental studies to model arching within LTP using cohesionless fill are summarized. This paper presents an …

Undermining The Responsibility For Climate Change: An Overview And Forecast, Robert Agnew, Jennifer Agnew

International Journal on Responsibility

This paper first examines the extent to which individuals feel responsible for addressing climate change. It next provides an overview of the factors undermining responsibility. Such factors include the efforts of the fossil fuel industry and its allies to deny climate change, the political division surrounding climate change, a range of structural and social constraints, certain features of climate change, and selected individual values and traits. The core part of the paper then asks whether the responsibility for addressing climate change will increase as the effects of climate change become more common and severe. While there is some reason to …

Bibliometric Analysis Of Applications And Research Trends On Whole Milk In Food Science, Nautus Stivano Dalle, Juni Sumarmono

Jurnal Ilmu Ternak Universitas Padjadjaran

This study maps the scientific landscape and research trends on whole milk in food science using a bibliometric approach. Data were collected from Google Scholar via Publish or Perish 8 (2020–2025) using the keyword "whole milk," yielding 291 documents after applying inclusion criteria. Descriptive and visual analyses were performed using VOSviewer and the Bibliometrix package to identify publication trends, collaboration networks, and dominant themes through co-authorship and keyword co-occurrence analyses. Results revealed fluctuating publication patterns, peaking in 2021 (60 articles) and declining in 2025 (41 articles). Keyword mapping identified four major clusters: microbiological characterization and probiotic potential, milk bioactive and …

Physicochemical, Organoleptic, And Antioxidant Functional Characteristics Of Dangke Whey Protein Ice Cream Fortified With Butterfly Pea Flower Extract, Muh. Achyar Ardat, Raden Hilman Wirayudha, Ekajayanti Kining, Zakiah Wulandari, Irma Isnafia Arief

Jurnal Ilmu Ternak Universitas Padjadjaran

This study aims to develop a functional ice cream based on dangke whey pro‐ tein with the addition of butterfly pea flower extract. Four formulations were pre‐ pared by varying milk and whey proportions: P1 (100% milk), P2 (60% milk + 40% whey), P3 (40% milk + 60% whey), and P4 (100% whey), with 5% butterfly pea ex‐ tract added to each treatment. The results showed that higher whey substitution decreased pH and overrun values but prolonged the melting resistance of ice cream. Moisture content increased with whey proportion, whereas ash content remained relatively constant across treatments. Protein and fat …

Consumer Preferences And The Impact Of Halal Labeling On Beef Purchasing Decisions In Modern Market Segments, I Putu Gede Didik Widiarta, Amalina Nur Wahyuningtyas, Andi Nurmasytha, I Gede Arie Mahendra Putra

Jurnal Ilmu Ternak Universitas Padjadjaran

Global demand for halal-certified products is rapidly increasing, underscoring the importance of understanding consumer preferences and the impact of halal labelling on purchasing decisions. This study examines the relationship between halal labelling, consumer trust, and purchasing behaviour of beef in modern markets in East Kalimantan, Indonesia. A quantitative survey was conducted with 400 respondents from diverse demographic backgrounds. The results show that 75% of consumers prefer halal-certified beef, with 80% perceiving halal labels as indicators of superior product quality and safety. Logistic regression analysis revealed that consumers who trust halal labels are 2.5 times more likely to purchase halal-certified beef …

Open Neighbourhood Edge Degree And Metric Descriptors Qspr And Multi Criteria Analysis Of Chemicals And Antiviral Drugs, Gayathri A Ms

Theses and Dissertations

Chemical Graph theory offers powerful computational methods for evaluating chemical structures, significantly impacting cheminformatics and drug analysis. It provides a robust mathematical framework to represent, model, and analyse molecular systems through topological indices and graph invariants. These indices serve as effective numerical descriptors, encapsulating significant structural information that enhances the prediction of physicochemical and biological properties. This thesis utilizes mathematical modeling, algorithmic computation, and decision making process to derive extensive insights to drug discovery and molecular analysis.

The thesis introduces a new class of topological indices ONE1, ONE2, ONE3, ONE4, ONE5,ONE6 and ONE7 based on open-neighbourhood-edge-degree and it evaluates the …

Veronica Serpas-Joya V. Attorney General United States Of America

2026 Decisions

Agency

Director Review Analysis, Brandon Theiss, Daniel Golub

Chicago-Kent Journal of Intellectual Property

No abstract provided.