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Articles 39781 - 39810 of 1183539
Full-Text Articles in Entire DC Network
Otolaryngology Practitioner Attitudes Toward Human Papillomavirus Vaccination In Academic Otolaryngology Clinics, Dante J. Merlino, Katelyn S. Rourk, George B. Sankar, Adam J. Luginbuhl, Brian J. Boyce, Michelle M. Chen, Eric M. Dowling, Michael C. Topf, Raymond L. Chai, Karthik Rajasekaran, Eric J. Moore, Daniel L. Price, George Saieed, Kathryn M. Van Abel
Otolaryngology Practitioner Attitudes Toward Human Papillomavirus Vaccination In Academic Otolaryngology Clinics, Dante J. Merlino, Katelyn S. Rourk, George B. Sankar, Adam J. Luginbuhl, Brian J. Boyce, Michelle M. Chen, Eric M. Dowling, Michael C. Topf, Raymond L. Chai, Karthik Rajasekaran, Eric J. Moore, Daniel L. Price, George Saieed, Kathryn M. Van Abel
Department of Otolaryngology - Head and Neck Surgery Faculty Papers
Despite the existence of a highly effective and safe vaccine against human papillomavirus (HPV) infection, vaccination rates remain low. The most prevalent HPV-associated malignancy in the United States is oropharyngeal cancer, but otolaryngology practitioners do not offer the HPV vaccine, and their feelings around offering HPV vaccination have not been evaluated. A 43-question survey, including a twelve-question knowledge quiz, was sent to otolaryngology practitioners at seven academic institutions. Twelve questions comprised a knowledge quiz testing practitioner understanding of HPV, while the remainder of the questions evaluated comfort with and likelihood of recommending vaccination. Of the 442 practitioners who were sent …
Thrombocytopenia In Sepsis, Alireza Setarehaseman, Robert W. Maitta
Thrombocytopenia In Sepsis, Alireza Setarehaseman, Robert W. Maitta
Faculty Scholarship
Platelets, traditionally known for their role in hemostasis, have emerged as key players in immune response and inflammation. Sepsis, a life-threatening condition characterized by systemic inflammation, often presents with thrombocytopenia, which at times, can be significant. Platelets contribute to the inflammatory response by interacting with leukocytes, endothelial cells, and the innate immune system. However, excessive platelet activation and consumption can lead to thrombocytopenia and exacerbate the severity of sepsis. Understanding the multifaceted roles of platelets in sepsis is crucial for developing effective therapeutic strategies. Targeting platelet-mediated inflammatory responses and promoting platelet production may offer potential avenues for improving outcomes in …
The Economics Of Large Language Models: Token Allocation, Fine-Tuning, And Optimal Pricing, Dirk Bergemann, Alessandro Bonatti, Alex Smolin
The Economics Of Large Language Models: Token Allocation, Fine-Tuning, And Optimal Pricing, Dirk Bergemann, Alessandro Bonatti, Alex Smolin
Cowles Foundation Discussion Papers
We develop an economic framework to analyze the optimal pricing and product design of Large Language Models (LLM). Our framework captures several key features of LLMs: variable operational costs of processing input and output tokens; the ability to customize models through fine-tuning; and high-dimensional user heterogeneity in terms of task requirements and error sensitivity. In our model, a monopolistic seller offers multiple versions of LLMs through a menu of products. The optimal pricing structure depends on whether token allocation across tasks is contractible and whether users face scale constraints. Users with similar aggregate value-scale characteristics choose similar levels of fine-tuning …
Mbnl Overexpression Rescues Cardiac Phenotypes In A Myotonic Dystrophy Type 1 Heart Mouse Model, Rong-Chi Hu, Yi Zhang, Larissa Nitschke, Sara J Johnson, Ayrea E Hurley, William R Lagor, Zheng Xia, Thomas A Cooper
Mbnl Overexpression Rescues Cardiac Phenotypes In A Myotonic Dystrophy Type 1 Heart Mouse Model, Rong-Chi Hu, Yi Zhang, Larissa Nitschke, Sara J Johnson, Ayrea E Hurley, William R Lagor, Zheng Xia, Thomas A Cooper
Faculty, Staff and Students Publications
Myotonic dystrophy type 1 (DM1) is an autosomal dominant disease caused by a CTG repeat expansion in the dystrophia myotonica protein kinase (DMPK) gene. The expanded CUG repeat RNA (CUGexp RNA) transcribed from the mutant allele sequesters the muscleblind-like (MBNL) family of RNA-binding proteins, causing their loss of function and disrupting regulated pre-mRNA processing. We used a DM1 heart mouse model that inducibly expresses CUGexp RNA to test the contribution of MBNL loss to DM1 cardiac abnormalities and explored MBNL restoration as a potential therapy. AAV9-mediated overexpression of MBNL1 and/or MBNL2 significantly rescued DM1 cardiac phenotypes including conduction delays, contractile …
Scientific Evidence: Impact On A Jury, Thomas B. Scavone
Scientific Evidence: Impact On A Jury, Thomas B. Scavone
Walden Dissertations and Doctoral Studies
The goal of this qualitative study was to better understand the impact of scientific evidence ‘s influence on a jury’s verdict. The presence of scientific evidence has the potential to convict the defendant or overturn a guilty verdict as seen in cases involving the innocence project. The theoretical framework for this qualitative study was Gerbner’s Cultivation Theory which postulates heavy exposure to television has the potential to influence the individual’s perception of the world. The researcher implemented an exploratory research design using purposive sampling. A total of 68 participants (prior jurors) applied for the study, 66 from an advertisement placed …
Engineered Immunomodulatory Extracellular Vesicles From Epithelial Cells With The Capacity For Stimulation Of Innate And Adaptive Immunity In Cancer And Autoimmunity, Xin Luo, Fernanda G Kugeratski, Dara P Dowlatshahi, Hikaru Sugimoto, Kent A Arian, Yibo Fan, Li Huang, Danielle Wills, Sergio Lilla, Kelly Hodge, Sara R Zanivan, Valerie S Lebleu, Kathleen M Mcandrews, Raghu Kalluri
Engineered Immunomodulatory Extracellular Vesicles From Epithelial Cells With The Capacity For Stimulation Of Innate And Adaptive Immunity In Cancer And Autoimmunity, Xin Luo, Fernanda G Kugeratski, Dara P Dowlatshahi, Hikaru Sugimoto, Kent A Arian, Yibo Fan, Li Huang, Danielle Wills, Sergio Lilla, Kelly Hodge, Sara R Zanivan, Valerie S Lebleu, Kathleen M Mcandrews, Raghu Kalluri
Faculty, Staff and Student Publications
Extracellular vesicles (EVs) are generated by all cells. Systemic administration of allogenic EVs derived from epithelial and mesenchymal cells have been shown to be safe, despite carrying an array of functional molecules, including thousands of proteins. To address whether epithelial cells derived EVs can be modified to acquire the capacity to induce immune response, we engineered 293T EVs to harbor the immunomodulatory molecules CD80, OX40L and PD-L1. We demonstrated abundant levels of these proteins on the engineered cells and EVs. Functionally, the engineered EVs efficiently elicited positive and negative co-stimulation of human and murine T cells. In the setting of …
Use Of Synthetic Water-Soluble Kcc2 To Modulate Chloride Homeostasis In Cultured Dopamine-Neuron-Like Cells, Mason Terry, Andrew Payne, Dario Mizrachi
Use Of Synthetic Water-Soluble Kcc2 To Modulate Chloride Homeostasis In Cultured Dopamine-Neuron-Like Cells, Mason Terry, Andrew Payne, Dario Mizrachi
Annual Research Symposium
No abstract provided.
Staff Attitude, Library Policies And Service Delivery In University Libraries In Ogun State, Nigeria, Ilori Edeole Maria Mrs, Owolabi Ruth O Dr, Oden Abigail N. Mrs, Ogungbade Aderonke A. Mrs
Staff Attitude, Library Policies And Service Delivery In University Libraries In Ogun State, Nigeria, Ilori Edeole Maria Mrs, Owolabi Ruth O Dr, Oden Abigail N. Mrs, Ogungbade Aderonke A. Mrs
Library Philosophy and Practice (e-journal)
University library services aim to meet the information needs of the university community, fostering learning and research. Quality service, particularly in tangible aspects and reliability, leads to user satisfaction. Staff attitude significantly impacts library service utilization, as does library policy, which guides library operations. The study adopted survey research design. The study population comprised 80,247 university library users in Ogun State, Nigeria. A sample size of 1,513 was determined using the Krejcie and Morgan (1970) method. Universities were stratified into federal, state, and private categories, and respondents were purposively selected. The findings indicate high-quality service delivery in university libraries in …
Complete Issue - Mend (Spring 2025), Mend Journal
Juneteeth, Sonny Cochran
Characterization Of 1,8-Cineole (Eucalyptol) From Myrtle And Its Potential Antibacterial And Antioxidant Activities*, Humera Khan
Characterization Of 1,8-Cineole (Eucalyptol) From Myrtle And Its Potential Antibacterial And Antioxidant Activities*, Humera Khan
Karbala International Journal of Modern Science
1,8-Cineole is a naturally occurring chemical molecule predominantly found in fragrant plants, particularly Myrtle. Its aroma is distinctive and has been the subject of numerous investigations due to its various biological actions. This study examines the characterization of 1,8-Cineole derived from Myrtle and investigates its antibacterial and antioxidant properties. This study seeks to compare 1,8-Cineole with antibiotics like Amoxicillin and Tetracycline, and moreover, to investigate its antioxidant capabilities against diverse bacterial strains (both Gram-positive and Gram-negative). 1,8-Cineole exhibits the most effective antibacterial properties, demonstrating an inhibition zone of 12.00 mm against Staphylococcus aureus and 10.00 mm against Pseudomonas aeruginosa. …
Shifting The Paradigm With Wednesday Addams: An Intersectional Analysis Of The First (Autistic) Female Latinx Detective, Camille Bassett, Jason Gilmore
Shifting The Paradigm With Wednesday Addams: An Intersectional Analysis Of The First (Autistic) Female Latinx Detective, Camille Bassett, Jason Gilmore
Communication Studies and Philosophy Student Research
For centuries, Autistic people have been portrayed in media through two dehumanizing stereotypes, the robot and the superhuman savant. Together, the robot and the superhuman savant combine into one of the most popular hybrid stereotypes to appear in media: the detective. Past detectives have been almost exclusively white male characters, a longstanding pattern that erases Autistic women and people of color, among others. In 2022, however, Netflix’s spinoff series of The Addams Family, Wednesday, brought to the screen the first-ever female Latinx detective. This study is a thematic analysis of Wednesday as a character, the autism …
Curricular Changes Proposed For 2025-2027 Morris Catalog, Curriculum Committee
Curricular Changes Proposed For 2025-2027 Morris Catalog, Curriculum Committee
Curriculum Committee Reports
No abstract provided.
The Joy Of Embodied Learning, Leslie Bayers
The Joy Of Embodied Learning, Leslie Bayers
Academic Affairs Faculty and Staff Books and Book Chapters
The science of embodied cognition has established that thinking involves dynamic exchanges between the body and the brain and webs of interaction between humans and their environments. While learning draws on these connected ecosystems, persistent notions of the brain as separate from and hierarchically managing the body—an enduring legacy of Cartesian dualism—perpetuate static teaching and learning mindsets. Disregard for the body’s role in learning fuels disengagement, isolation, and inequity. This chapter weaves key findings from embodied learning research together with scenes from the author’s own academic journey to illustrate how leveraging brain–body connections can foster educational well-being. The author shares …
A Comparison Study Of Senior And Junior Deck Officers’ Interpretations Of The International Regulations For The Prevention Of Collisions At Sea, Ian Heffernan, Tom O'Mahony
A Comparison Study Of Senior And Junior Deck Officers’ Interpretations Of The International Regulations For The Prevention Of Collisions At Sea, Ian Heffernan, Tom O'Mahony
Articles
The International Regulations for the Prevention of Collisions at Sea (IRPCS) provide a comprehensive set of instructions for watchkeeping officers to follow and prevent collisions at sea. This study compares how six newly qualified deck officers and six Master Mariners, who were all trained at the same college, applied the IRPCS. Individual, semi-structured interviews were used to uncover how the 12 participants applied and interpreted the rules for three authentic scenarios. Phenomenography was used to capture the qualitatively different means by which participants interpreted the IRPCS. For basic collision avoidance situations, the results indicated little difference between the cohorts' ability …
Casar Public Lecture: Will Trump End The Ukraine War?, The Prince Alwaleed Center For American Studies And Research Casar
Casar Public Lecture: Will Trump End The Ukraine War?, The Prince Alwaleed Center For American Studies And Research Casar
Performances, Events, and Presentations
Trump wants to become the world’s Peace Maker, the Master of the Art of Making Deals. He promised to end this war in 24 hours. Yet the real question is whether Putin wants to end the war, or whether he is ready for a deal ? If so, then what kind of a deal? Could it be that Putin might have a different deal in mind than the deal Trump is willing to offer?? So what happens then??? The lecture deliberated about the possible answers to this very question from several perspectives, analyzing the impact on Egypt, the region & …
Million-Dollar Mysteries: Recent Complex Patent Cases Lost To Rule 36, Dennis D. Crouch
Million-Dollar Mysteries: Recent Complex Patent Cases Lost To Rule 36, Dennis D. Crouch
Faculty Publications
This article examines the Federal Circuit's continued use of Rule 36 summary affirmances to dispose of complex patent cases without written opinions. Through analysis of eight recent Rule 36 cases decided in early 2025, the author demonstrates that sophisticated legal issues involving millions of dollars are being summarily affirmed despite presenting novel and important questions of patent law. The cases discussed involve design patent evidentiary standards, jury trial rights for hybrid legal-equitable claims, analogous art determinations, claim construction, written description requirements, and PTAB procedural issues. The author argues that while the court may be avoiding difficult cases with complex factual …
Tedor Davido V. Secretary Pennsylvania Department Of Corrections
Tedor Davido V. Secretary Pennsylvania Department Of Corrections
2025 Decisions
USDC for the Eastern District of Pennsylvania
The International Law Commission's Seventy-Fifth (2024) Session: Immunity Of State Officials From Foreign Criminal Jurisdiction And Other Topics, Charles C. Jalloh
The International Law Commission's Seventy-Fifth (2024) Session: Immunity Of State Officials From Foreign Criminal Jurisdiction And Other Topics, Charles C. Jalloh
Articles
The International Law Commission (Commission or ILC) held its seventy-fifth session at its seat in Geneva from April 15 to May 31 and from July 1 to August 2, 2024. The Commission was chaired by Mr. Marcelo Vázquez-Bermúdez (Ecuador), and for the first time since its establishment in 1945, elected a majority of three females out of the five officers elected to its bureau annually. The Commission celebrated its seventy-fifth anniversary and progressed its work on the topics in the program of work despite the shortening of the twelve-week General Assembly approved session to ten weeks due to the liquidity …
Against Moralizing Nature: Latin American Romanticism And The Aporias Of The Ecocritical Turn, Claudio Aguayo-Borquez
Against Moralizing Nature: Latin American Romanticism And The Aporias Of The Ecocritical Turn, Claudio Aguayo-Borquez
Modern Languages Faculty Publications
This article argues that the ecocritical turn in literary criticism reproduces the dualisms it seeks to avoid, especially the contradiction between nature and culture. At the same time, ecocriticism risks the veneration of Nature already practiced and promoted within the Romantic tradition in the global epoch of primitive accumulation during the 19th century. To sustain this argument, this article follows three main steps. In the first place, it establishes a characterization of Romanticism's attitude towards Nature, defining it as the literaturization of Nature, following Abrams' notion of supernatural naturalism and Jean Luc-Nancy and Philippe Lacoue-Labarthe's definition of Romanticism as the …
February 10 Elections, Census & Redistricting Update, Jeffrey M. Wice
February 10 Elections, Census & Redistricting Update, Jeffrey M. Wice
Elections, Census & Redistricting Updates
No abstract provided.
Student Affairs Minutes 02/10/2025, Student Affairs Committee
Student Affairs Minutes 02/10/2025, Student Affairs Committee
Student Affairs Committee
No abstract provided.
George Pitsilides V. William Barr
George Pitsilides V. William Barr
2025 Decisions
USDC for the Middle District of Pennsylvania
Crow's Nest, February 10, 2025, Crow's Nest Staff
Crow's Nest, February 10, 2025, Crow's Nest Staff
Crow's Nest
The February 10, 2025, issue of Crow's Nest.
The Free Press Vol. 56, Issue 9, 02-10-2025, Chris Tiner, Cayley Bowman
The Free Press Vol. 56, Issue 9, 02-10-2025, Chris Tiner, Cayley Bowman
Free Press, The
ICE Infographic--Criminology club is back--Letters from the Editors--America: A New Era--The Guy Who Didn't Like Musicals--Lost Poems by Jim Morrison--Patriots Blow It Big Time--Blockbuster NBA Trade
Sixth Amended Disclosure Statement
Sixth Amended Disclosure Statement
Catholic Dioceses in Bankruptcy
No abstract provided.
Committee's Response To Survivor Statements
Committee's Response To Survivor Statements
Catholic Dioceses in Bankruptcy
No abstract provided.
Violence Among Nigeria’S Female And Predictors Of Help-Seeking Behavior Using Technology, Abayomi Karunwi
Violence Among Nigeria’S Female And Predictors Of Help-Seeking Behavior Using Technology, Abayomi Karunwi
Walden Dissertations and Doctoral Studies
The decision-making autonomy of female intimate partner violence (IPV) survivors to make financial transactions is a stronger predictor of help-seeking behavior that is not yet fully explored. Despite the plausibility of using the mobile phone for financial transactions, it is yet to be explored as a predictor of help-seeking behavior after IPV events through digital financial inclusion. The dataset from the 2018 Nigerian Demographic Health Survey was used to explore if digital financial inclusion could predict help-seeking behavior instead of the severity of abuse among ever-partnered Nigerian female IPV survivors (aged 15 to 49 years) who use their mobile phones …