Digital Commons Network^™

Restoration Of The Tumor Suppressor Function Of Y220c-Mutant P53 By Rezatapopt, A Small-Molecule Reactivator, Anna M Puzio-Kuter, Lizhong Xu, Mary Kate Mcbrayer, Romyr Dominique, Hongju H Li, Bruce J Fahr, Alyssa M Brown, Amy E Wiebesiek, Brandon M Russo, Chris L Mulligan, Hong Yang, Josh Battaglia, Kimberly A Robell, Dafydd H Thomas, Kuo-Sen Huang, Alexander Solovyov, Benjamin D Greenbaum, Jonathan D Oliner, Thomas W Davis, Melissa L Dumble, Melissa L Johnson, Shunbin Xiong, Peirong Yang, Guillermina Lozano, Marc M Fellous, Binh T Vu, Alison M Schram, Arnold J Levine, Masha V Poyurovsky

Faculty, Staff and Student Publications

Restoration of the tumor suppressor function of tumor-associated p53 mutants, including the Y220C substitution, has posed a significant challenge for therapeutic discovery. In this study, we describe rezatapopt (PC14586), part of a series of compounds designed to reactivate the p53 Y220C mutant. These compounds restore p53 tumor suppressor function by correcting its conformation and enabling it to bind DNA and activate downstream target genes, thus inducing antiproliferative changes in tumor cells. Our findings are supported by biochemical and structural analysis, in vitro and in vivo transcriptomics, and functional data, revealing the recovery of multiple aspects of the wild-type p53 program. …

A Century Of Servant Leadership: Jimmy Carter, Jeffrey H. Coats

Servant Leadership: Theory & Practice

This paper describes the servant leadership characteristics of Jimmy and Rosalyn Carter.

Maghrebi Identity & Integration In France: Colonial Legacies And Contemporary Realities, Mariam Gohar

SUURJ: Seattle University Undergraduate Research Journal

Historical ties between France and the Maghreb continue to shape and inform the experiences of the Maghrebi population in contemporary French society. There is an extensive Maghrebi population in France as a result of France’s colonial history in the region and subsequent migration. The Maghrebi populations face structural and social barriers in French society, including employment and education disparities, spatial segregation, and social Otherization. Maghrebi communities are only one example of France’s structural discrimination against non-European populations. This work aims to unpack the historical, political, and economic factors that resulted in French colonization of the Maghreb and relate these to …

Reframing Fat: Identifying Compulsory Thinness And The Role Of Discourse And Media In Its Perpetuation, Anabella Vucci

SUURJ: Seattle University Undergraduate Research Journal

Drawing on Judith Butler’s framework of compulsory heterosexuality, as well as Robert McRuer’s use of this framework in his own theory of compulsory able-bodiedness, this paper critiques the notion that thinness is merely a beauty standard. Rather, this paper argues that thinness is a marker of superiority that requires the subordination of fat individuals and is upheld by the historically informed, albeit fabricated, narrative that being thin is right. This paper asserts that thinness is compulsory—required from all bodies that are held to an unattainable standard of perfect thinness. Further, this paper examines the role that media play in the …

Speech By Hh The Aga Khan At The Inauguration Of The Aga Khan University's Faculty Of Health Sciences And Of The Aga Khan University Hospital, Karachi

Inaugural addresses and related documents

No abstract provided.

First Convocation Address By Hh Ghulam Ishaq Khan, President Islamic Republic Of Pakistan

Speeches from convocations, inaugurations, and major events

No abstract provided.

Siliciclastic Cave Or Diamond Mine? Multiapproach Investigation In Igatu Village, Chapada Diamantina, Northeastern Brazil, Raphael Parra, Ricardo G. F. De A. Pereira, Leonardo F. Vieira, Rubson P. Maia

International Journal of Speleology

The territory around Igatu, as that of many villages in southeastern Chapada Diamantina (Bahia, Brazil), was deeply modified by diamond mine activity. Caves were special targets for miners, since they can act as diamond-bearing sediment traps, and the Canal da Fumaça Cave was one of the most important and rich of them. The question that arises is whether the formation is a natural cave or an artificial diamond mine. In order to answer this question, we developed speleological and geological studies with detailed cave surveys, remote sensing and field measurements for structural analysis, optical and electronic microscope for petrographic characterization, …

Developing Full Performance Interpreters: Cultivating Interdisciplinary Mindsets And Skillsets To Engage Audiences In Climate Change, Women's History, And Other Contested Heritage Topics, Delia A. Lister

Dissertations

Heritage sites immerse visitors in places where the impacts of climate change are readily apparent. They are also powerful places to elevate untold stories of women and girls. Heritage site interpreters interact daily with audiences who bring diverse lived experiences, different levels of subject matter knowledge, and multiple perspectives on climate change and the role of women in history. Every visitor interaction has a set of meanings, values, and narratives that visitors knowingly or unknowingly espouse. To interpret contested heritage topics, such as climate change and women’s history, interpreters must cultivate interdisciplinary mindsets and skillsets. The purpose of this basic …

In Re: Darrell Hubbard

2025 Decisions

USDC for the District of New Jersey

Michael Coniker V. Jeffrey Monfortoh

2025 Decisions

USDC for the Western District of Pennsylvania

Jason Samaritano V. State Of New Jersey

2025 Decisions

USDC for the District of New Jersey

Usa V. Jason Weigand

2025 Decisions

USDC for the Eastern District of Pennsylvania

Accessibility To Public Spaces: Intersections Between The Courts And The Houseless Community, Margaret Maxey

Dissertations and Theses

In an attempt to answer the question of what role the judiciary played in affecting access to public spaces from the 1960's to 2024, this thesis identifies an accumulation of patterns relating to the courts' role in accessibility of public parks and their amenities over this time period. The data supplied for this question is drawn from scholars focusing on judicial decisions and political theory relating to public spaces, including those mentioned above. The result of this study will include a close examination of the role the judiciary holds as a cornerstone institution in not only our democracy, but in …

Prescribed Fire Leads A Pine Flatwoods Specialist Tree Frog To Seek Local Refugia, Ian Biazzo, Pedro F. Quintana-Ascencio

Faculty Publications

Pine savannas of the southeastern United States evolved with frequent low-intensity wildfires. Today, land managers use prescribed fires to restore this ecological process while also controlling vegetative fuel accumulation. Given the ubiquitous application of this management tool, studies should consider impacts on target and nontarget taxa in these systems. During fires, animal populations persist in the landscape when individuals emigrate to unburned areas or seek refugia within the burn zone; otherwise, they experience local extirpation. We examined the effect of prescribed fires on a pine flatwoods specialist frog, the pinewoods treefrog Dryophytes femoralis, in a frequently burned pine landscape. …

June 2 Elections, Census & Redistricting Update, Jeffrey M. Wice

Elections, Census & Redistricting Updates

No abstract provided.

The Supernatural Shadow Of The Philosophic Fallacy: A Critical Examination Of John Dew-Ey’S Experience And Nature, Danica Jenck

Center for Dewey Studies Essay Award

In Experience and Nature, John Dewey asserts the existence of the philosophic fallacy. He describes the philosophic fallacy as understanding reality through abstractions rather than material causes that are situated in experience. However, Dewey’s writings on moral and religious development, particularly his criticisms of the supernatural, puts his philosophic fallacy into question. I argue that Dewey’s rejection of the supernatural is a mistake that limits his ability to clearly articulate his metaphysical project, demonstrating that Dewey’s rejection of supernatural experience commits the philosophic fallacy and is based in a Eurocentric tendency that can be escaped by challenging Eurocentric metaphysical …

Arts-Based Sustainability: From New York To Malawi, Martha B. Lerski

Publications and Research

Recognizing that libraries serve multiple constituencies and subject areas, this chapter documents and advocates for development of transdisciplinary arts-based research (ABR) and culture-related projects linked to environmental challenges. Libraries contribute collections and spaces, as well as the research of library and information scientists. Libraries are currently among invisible contributors to sustainability planning and services. The chapter will link this invisibility to the value of what visual arts refer to as negative space elements in subjects ranging from traditional ecological knowledge to environmental science. Library collections, projects, and research contribute to education for sustainable development (ESD) as required to achieve the …

What Are “Wartime Authorities” And When Can The President Use Them? An Expert Q&A, Tess Bridgeman, Rebecca Ingber, Scott Roehm

Online Publications

The first several months of President Donald Trump’s second administration have been marred by the chaotic and often unlawful use, or threatened use, of wartime and terrorism-related authorities for what are essentially domestic immigration or criminal law enforcement purposes. This is not the first time a president has sought to push the boundaries of his wartime powers, or outright claimed those he did not have, but it may well be the most extreme. Indeed, Trump’s reliance on wartime authorities in contexts entirely divorced from armed conflict, or even the threat of force against the United States, puts the country on …

Innate Lymphoid Cells In Inflammatory Bowel Disease, Xin Yao, Kaiming Ma, Yangzhuangzhuang Zhu, Siyan Cao

2020-Current year OA Pubs

Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a chronic inflammatory disorder of the gastrointestinal tract with rising incidence and an unclear etiology. Innate lymphoid cells (ILCs) have recently emerged as key regulators of mucosal immunity and tissue homeostasis and are increasingly implicated in IBD. Unlike adaptive lymphocytes, ILCs do not require antigen recognition and clonal expansion to respond rapidly to environmental cues and shape immune responses. In a healthy gut, ILCs maintain intestinal homeostasis by guarding the epithelial barrier, protecting against pathogens, and mounting proper responses to external insults. However, their altered differentiation, proliferation, recruitment, activation, …

Estimated Burden Of Coccidioidomycosis, Samantha L Williams, Andrej Spec, Et Al.

2020-Current year OA Pubs

IMPORTANCE: Coccidioidomycosis is an underrecognized fungal infection that can cause serious illness and constitutes a considerable public health burden. The number of cases is likely substantially higher than the nationally reported total, as surveillance does not capture patients who do not seek medical care or who are undiagnosed or misdiagnosed. Coccidioidomycosis is not reportable in all states, and cases not reported to public health entities are likewise missed. A systematic estimate of coccidioidomycosis burden is needed to raise awareness and inform public health interventions and policy.

OBJECTIVE: To assess the annual burden of symptomatic coccidioidomycosis in the US.

DESIGN, SETTING, …

Climatologist Mann's Defamation Suit Victory: Can It Resolve The Crisis Of Expertise, David S. Caudill

Faculty Publications

When a jury awarded one million dollars in punitive damages to climatologist Michael Mann, in his defamation suit against writer Mark Steyn (who accused Mann of scientific fraud), it was newsworthy, even surprising, because opinions regarding scientific matters are rarely actionable. And yet it was not seen as a groundbreaking event in terms of legal doctrine, since the outcome was easily justifiable— Steyn’s accusation was provably false. However, even if the Constitutional contours of defamation law did not change, the Mann verdict has far-reaching implications for a major contemporary social phenomenon, namely the so-called crisis of expertise, a term identifying …

Investigating The Obstacles Of K-12 Saudi Teachers In The Use Of Educational ‎Technology ‎, Mohammed Albaqami

Tennessee State University Alumni Theses and Dissertations

The purpose of this study was to investigate the obstacles that K-12 teachers in general education schools in the Kingdom of Saudi Arabia face when implementing technology into their classrooms. This study was conducted within the city of Riyadh, Saudi Arabia. The purpose of the current study is to identify the degree of use of educational technology by teachers in K-12 schools, in addition to investigating teachers' perceptions about the obstacles using educational technology in K-12 schools in relation to the teachers, administration, and technology. The questions of this study were, therefore, “What is the degree of use of educational …

Faculty Adoption And Awareness Of Online Education Technologies And 360° Video, Carrie Elizabeth Cook

Tennessee State University Alumni Theses and Dissertations

This study explored faculty perceptions of distance education and the potential integration of immersive 360° video technology in higher education. To understand how faculty use online learning and a specific form of immersive learning, the Technology Acceptance Model (TAM) served as the theoretical foundation for this study. This study employed a descriptive research design to assess faculty attitudes, and surveys conducted with a researcher adapted version of a proven instrument were conducted with Tennessee State University (TSU) faculty. The findings of this study revealed that faculty perceptions of distance education were influenced by concerns about engagement, technological barriers, and comparisons …

Investigating The Obstacles Of K-12 Saudi Teachers In The Use Of Educational ‎Technology ‎, Mohammed Albaqami

Tennessee State University Alumni Theses and Dissertations

The purpose of this study was to investigate the obstacles that K-12 teachers in general education schools in the Kingdom of Saudi Arabia face when implementing technology into their classrooms. This study was conducted within the city of Riyadh, Saudi Arabia. The purpose of the current study is to identify the degree of use of educational technology by teachers in K-12 schools, in addition to investigating teachers' perceptions about the obstacles using educational technology in K-12 schools in relation to the teachers, administration, and technology. The questions of this study were, therefore, “What is the degree of use of educational …

Measuring Emotional Intelligence With The Msceit 2: Theory, Rationale, And Initial Findings, John D. Mayer, David R. Caruso, Peter Salovey, Iris Y. Lin, Braden J. Hansma, Joanna Solomon, Gill Sitarenios, Manolo Romero Escobar

UNH Personality Lab

Introduction: The model of emotional intelligence as an ability has evolved since its introduction 35 years ago. The revised model includes that emotional intelligence (EI) is a broad intelligence within the Cattell-Horn-Carroll (CHC) model of intelligence, and that more areas of problem solving are involved than originally detailed. An argument is made here that veridical scoring of EI test responses is a sound procedure relative to scoring keys based on expert consensus or a single emotion theory. To the degree that EI fits present-day theories of intelligence (i.e., the CHC model), any subsidiary factors of EI reasoning should correlate highly …

Gomez V. Gomez

All Decisions

The court denied the tenant's motion for a stay and undertaking pending an interlocutory appeal of an order denying dismissal of a holdover petition. The court clarified that CPLR 5519(a)(6) automatic stays only apply to judgments or orders requiring enforcement, such as an eviction. Since the appealed order merely denied dismissal and transferred the case to trial, not directing any specific enforcement action against the tenant, an automatic stay was not warranted.

Hudson Shore Associates Limited Partnership, Haven On The Hudson Llc, Kenneth Levinson, And Hudson Valley Property Owners Association Et Al. V. State Of New York, New York State Division Of Housing And Community Renewal, Village Of Nyack, New York, And City Of Poughkeepsie, New York

All Decisions

Landlords challenged New York's Vacancy Provisions, alleging Fourth Amendment violations for warrantless searches of rent rolls and Fourteenth Amendment due process violations concerning vacancy calculations. The court affirmed dismissal, holding that Article 78 proceedings provide sufficient pre-compliance review for record demands, and the low risk of coercion mitigates Fourth Amendment concerns. Due process was satisfied by opportunities for landlords to contest vacancy calculations through public hearings and subsequent Article 78 review, ensuring constitutional muster.

Bedford 203 Lp V. Santana

All Decisions

In a nuisance holdover case, the court partially granted the tenant's motion to dismiss, specifically dismissing allegations that the tenant's behavior "annoyed" other tenants, as the lease required a notice to cure for such conduct, which the landlord failed to provide. However, the court allowed the remaining nuisance allegations to stand, finding no notice to cure was required for conduct impacting building staff or the landlord's guests. The court also permitted the landlord to amend the petition to correctly reflect the apartment's regulatory status as part of the NYC 15/15 Project Based Program, finding no prejudice to the tenant.

Social-Emotional Learning (Sel) Support Through Social Work Case Management In K-12 Schools, Dina Michelle Garrett-Parker

Walden Dissertations and Doctoral Studies

Existing research revealed that K-12, school-based social work clinicians were utilized in various ways to support students' social-emotional learning (SEL) needs in public K-12 schools in the United States. However, there was a gap in knowledge about the unique approaches K-12 school-based social work clinicians employed to address the SEL needs of non-at-risk students. This basic qualitative study explored how K-12 school-based social work clinicians used empowerment case management practices to address the SEL needs of non-at-risk students. The theoretical framework grounding this study was empowerment theory. Using purposive sampling, semistructured interviews were conducted with five K-12 school-based social work …

Max Weber Vs Émile Durkheim: Pertarungan Paradigma Dalam Sosiologi Hukum Di Indonesia, Ilham Yuli Isdiyanto

Jurnal Hukum & Pembangunan

This study compares the thoughts of Max Weber and Emile Durkheim in the field of sociology of law and their relevance to the development of law in Indonesia. Weber emphasizes formal rational law through a positivistic approach, highlighting individual rationality in shaping social structures. In contrast, Durkheim views law as a tool of social solidarity rooted in morality and collective norms. This study employs a normative method integrated with hermeneutic philosophy, delving into the meaning of legal concepts through an in-depth interpretation of doctrines, theories, and legal literature. A descriptive-narrative analysis is conducted to understand the historical, social, and philosophical …