Digital Commons Network^™

The Quest For Algorithmic Justice In The Workplace: The Equal Employment Opportunity Commission And Other Federal Responses To Ai, Technology, And Enhanced Dangers Of Employment Discrimination, David Lopez

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

Severe Asthma Questionnaire (Saq) And Asthma Control Questionnaire (Acq) As Early Predictors Of Biologic Response In Severe Asthma, Drew Davies, Joseph W. Lanario, Michael E. Hyland, Matthew Masoli

Peninsula Medical School

Background: Biologic therapy in asthma can be life-changing and affect health-related quality of life, but symptoms are rarely used in the assessment of response. Aim: To examine the change in health-related quality of life and asthma control between starting a biologic and assessment of biologic response, assessing whether this change can provide early prediction of eventual clinical response at 12 months. Methods: A service evaluation of severe asthmatics initiating a biologic at the Royal Devon NHS trust between 2019 and 22. Health-Related Quality of Life (Severe Asthma Questionnaire) and asthma control (Asthma Control Questionnaire-6) was captured at baseline, 8 weeks, …

Executive Watch: Zick On Executive Orders And Official Orthodoxies, Timothy Zick

Popular Media

During his first term as president, Donald Trump signaled that he was not committed to pluralism and expressive liberty when it came to matters like patriotism, public protest, and other forms of dissent. During his second term, Trump has issued multiple executive orders that attempt to impose official orthodoxies or understandings regarding race, gender, patriotism, and other subjects.

As we have seen, these edicts are not merely symbolic. The executive orders call for agency actions and criminal investigations, and place hundreds of millions of dollars in federal funding at risk. The orders have affected what universities teach, which immigrants can …

Redefining Roles In Displacement: The Asylum Journey Of Sudanese Women In Faisal, Cairo, Majeda Abdin Mahasneh

Theses and Dissertations

This study examines how Sudanese refugee women, who arrived in Faisal, Cairo, after April 2023 experience gender-based violence (GBV). The research investigates the types of GBV these women encountered during their journey from Sudan to Cairo, how their gender roles changed in the asylum context, and their vision for the future regarding safety and support. A qualitative approach was employed, using in-depth interviews with four Sudanese refugee women, complemented by field notes and observations made during visits to the Faisal neighborhood. The analysis focused on the personal stories shared by the women, highlighting the various forms of violence they experienced, …

Afghanistan: An Analysis Of U.S. Foreign Policy’S Effect On Afghan Terrorism Rates, Katelyn E. Tinsley Foust

Honors Theses

While the term ‘terrorism’ was first coined and widely used in the late 1700s regarding the French Reign of Terror, its popularity has grown dramatically around the globe in the last few decades. Advancements in things like technology and news reporting have made these attacks more popular and have given terrorists an easier outlet to be recognized around the world. One such area we hear about often is the Middle East and the Levant. Countries like Afghanistan, Iraq, Syria, Israel, and more, are routinely discussed in our news cycles here in the United States, especially since the terrorist attacks on …

Beyond Victory And Settlement: Rethinking War Termination Through Post-Conflict Conditions, Emery C. Thigpen

Honors Theses

This thesis examines how different war termination types—decisive military victory, negotiated settlement, and ceasefire—shape long-term political stability through the mechanisms of enforcement, political inclusion, and economic recovery. While much of the existing literature focuses on civil wars, this study applies those insights to interstate conflicts, arguing that stability depends not on how wars end, but on whether post-war structures support compliance, legitimacy, and economic resilience. The central claim is that post-war peace is more likely to endure when enforcement mechanisms deter spoilers, inclusive political frameworks prevent renewed grievances, and economic recovery restores state capacity and legitimacy. Using a most similar …

A Search For Transcriptional Cofactors Of Gcm/Repo Involved In Determining Glia Cell Fate In Drosophila Melanogaster, Nivedha Kosalram

Honors Theses

In Drosophila melanogaster, the mechanism influencing the differentiation of glia and neurons is directed by a key transcription factor known as glial cells missing (gcm). gcm is a crucial regulator of cell fate decision, functioning as a binary switch to direct glial fate in gcm- positive cells and neuronal fate in gcm-negative cells (Jones, et.al, 1995; Hosoya, et.al, 1995; and Vincent, et.al, 1996). In addition to directing gliogenesis, gcm and its homolog gcm2 facilitate the determination of macrophages and tendon cells, highlighting that gcm acts with supplementary factors to induce various signaling pathways in different contexts (Jones, 2005; Johnson, et …

Economic Development In Cartersville, Ms: A Case Study Of A Non-Profit Organization's Community Development Projects, Mckenzie B. Perkins

Honors Theses

The Mississippi Delta Region has long faced significant economic, educational, and health challenges and a steady population decline since the 1940s. In response, community development projects have emerged as powerful tools to promote health, well-being, and social mobility. This thesis investigates the impact of community development initiatives in Cartersville, MS, focusing on the dental clinic, educational programs, and the economic development center established by a non-profit organization. Through the lens of community development theories, the research explores how community leadership, particularly partnerships between EverHope Ministries and Cartersville leaders, is pivotal in addressing health disparities in historically marginalized populations. By engaging …

A Local Assessment Of Glp-1 Use For Weight Loss: An Interview Study, Maci Bradley

Honors Theses

Glucagon-like peptide-1 (GLP-1) receptor agonists are a novel class of medications used primarily for the treatment of type 2 diabetes, as well as for chronic weight management. The first GLP-1 medication, exenatide, was FDA-approved in April of 2005 for glycemic control, however, it was not until December of 2014 when liraglutide became the first GLP-1 FDA-approved for weight loss. There are now eight FDA-approved GLP-1s, only two of which are approved for weight loss. GLP-1 use has become increasingly popular in recent years, even extending to the college-aged population. The purpose of this study is to examine the trends in …

Building Community Through Food And Health: Student Initiatives To Address Food Insecurity In Mississippi, Sarah E. Sawaya

Honors Theses

This thesis explores food insecurity in Oxford and Lafayette County, Mississippi, within the broader context of state, national, and global challenges. Over a four-year period, student-led and community organizations collaborated to design programs that addressed both food access and chronic illness prevention through education, outreach, and direct service. Community input was gathered through health screenings, campus engagement, and informal interviews with residents, which guided the development of practical tools like recipe kits, QR code-based cookbooks, and on-site health education. These efforts were rooted in local partnerships and shaped by the lived experiences of those most affected. This project demonstrates that …

Have Modern Total Knee Arthroplasty Implant Improvements Affected Revision Rates? A Registry Review Of Modern Implants And Their Predecessors, Alan D. Lam, John Hobbs, Nihir Parikh, David Pipa, Arjun Saxena, Andrew Star

Student Publications

Introduction

Total knee arthroplasty (TKA) is a common orthopaedic procedure used to alleviate pain and restore mobility in patients with knee pain. Substantial resources are committed to updating and refining new knee implant designs to improve outcomes. The aim of this study was to compare revision rates and failure modes between newer implants and their older counterparts.

Methods

A systematic literature review of national registries was conducted to identify predecessor and successor implant designs from four manufacturers. Individual implant revision data points for each implant design across the registries were compared between generations by manufacturer. Reported revision rates of TKA …

A Subset Of Senescent Myofibroblasts Orchestrates Immunosuppression In Pancreatic Cancer., Jad Belle

Arts & Sciences Graduate Student Theses and Dissertations

Pancreatic Ductal Adenocarcinoma (PDAC) is the most lethal solid malignancy with a 12% 5-year survival rate. Most tumors are detected at metastatic stages that are extremely resistant to therapy. PDAC recalcitrance is driven by a unique tumor microenvironment (TME) comprising dense collagenous fibrosis embedded with an abundance of cancer associated fibroblasts (CAFs) and infiltrating leukocytes. Preclinical studies have indicated that PDAC CAFs can have both pro- and anti-tumorigenic effects. This is likely owed to CAF phenotypic heterogeneity which was recently uncovered by single cell transcriptomics. Three major CAF subpopulations have been identified in mouse and human PDAC thus far: myofibroblastic …

Developing Organizational Leaders’ Personal Mastery Through Emotional Intelligence Training In The Workplace: An Interpretive Phenomenological Analysis, Billie Bruce Relyea

Walden Dissertations and Doctoral Studies

Mayer and Salovey, seminal researchers of emotional intelligence (EI), indicated that the ability measures of EI are still evolving, and the mental abilities involved in EI remain to be determined. Organizational leaders should understand this intention as the key to developing EI and personal mastery, resting firmly upon attaining accurate self-awareness as a prerequisite for human behavior. The purpose of this interpretive phenomenological analysis was to gain an understanding of the socially constructed realities of the lived experiences of organizational leaders and organizational development specialists who have completed Ennea International’s 5 Lens Development Platform (5LDP). Bandura’s social cognitive theory grounded …

A Voting Obstacle Course: Improving And Codifying New Hampshire Absentee Voting, Jessica Mcgloin

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

Exposing Lived Experiences: Eudora Welty's Intersectional Approach To Writing And Photography, Caroline Mccutchen

Honors Theses

This thesis examines how Eudora Welty employs an intersectional approach in her writing and photography to represent the complex identities of elderly Black women in the American South during the Great Depression. Using intersectionality as a framework, this project analyzes how Welty’s work acknowledges the overlapping forces of race, gender, age, and class that shape her subjects’ lived experiences. While documenting adversity, Welty also highlights resilience, agency, and communal empowerment. The study focuses on Welty’s literary works “A Worn Path,” “Ida M’Toy,” “A Pageant of Birds,” and “Cindy and the Joyful Noise,” alongside her Depression-era photographs from One Time, One …

Artificial Intelligence For Lawyers And Law Students: Crutch, Craft, Or Catalyst?, David S. Kemp

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

From Factory Floors To Courtroom Doors: The New Jersey Law Revision Commission Review Of An Exception And A Defense To The Exclusive Remedy Of The New Jersey Workers’ Compensation Act, Whitney G. Schlimbach, Carol Disla-Roa

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

Quantitative Ai Risk Assessments: Opportunities And Challenges, David Piorkowski, Michael Hind, John Richards

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

The Ttp As An Effective Response To Sffa, Michael Asante-Appiah

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

002nd Amendment: License To Abuse While Armed? The Intersection Of Intimate Partner Violence And Second Amendment Rights, Laura Burkett

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

Discovery Of Novel, Potent, And Orally Bioavailable Smarca2 Proteolysis-Targeting Chimeras With Synergistic Antitumor Activity In Combination With Kirsten Rat Sarcoma Viral Oncogene Homologue G12c Inhibitors, Sasikumar Kotagiri, Yawen Wang, Yanyan Han, Xiaobing Liang, Nicholas Blazanin, Hira Mazhar, Manu Sebastian, Phuong Kieu Nguyen, Yongying Jiang, Yonathan Lissanu

Faculty, Staff and Student Publications

Cancer genomic studies have identified frequent mutations in subunits of the SWI/SNF chromatin remodeling complex, including SMARCA4 in nonsmall cell lung cancer with a frequency of up to 33% in advanced-stage disease, making it the most frequently mutated complex. We and others have identified SMARCA2 to be synthetic lethal to SMARCA4, indicating that SMARCA2 is a high-value therapeutic target. Here, we disclose the discovery and characterization of potent, selective, and orally bioavailable cereblon-based SMARCA2 PROTACs. Biochemically, we showed that YDR1 and YD54 are potent SMARCA2 degraders. Further, we showed the antitumor growth inhibitory activity of YDR1 and YD54 in SMARCA4 …

Metabolic Reprogramming Driven By Ant2 Deficiency Augments T Cell Function And Anti-Tumor Immunity In Mice, Omri Yosef, Leonor Cohen-Daniel, Oded Shamriz, Zahala Bar-On, Wajeeh Salaymeh, Amijai Saragovi, Ifat Abramovich, Bella Agranovich, Veronika Lutz, Joseph Tam, Anna Permyakova, Eyal Gottlieb, Magdalena Huber, Michael Berger

Faculty, Staff and Student Publications

T cell activation requires a substantial increase in NAD+ production, often exceeding the capacity of oxidative phosphorylation (OXPHOS). To investigate how T cells adapt to this metabolic challenge, we generate T cell-specific ADP/ATP translocase-2 knockout (Ant2-/-) mice. Loss of Ant2, a crucial protein mediating ADP/ATP exchange between mitochondria and cytoplasm, induces OXPHOS restriction by limiting ATP synthase activity, thereby impeding NAD+ regeneration. Interestingly, Ant2-/- naïve T cells exhibit enhanced activation, proliferation and effector functions compared to wild-type controls. Metabolic profiling reveals that these T cells adopt an activated-like metabolic program with increased mitobiogenesis and anabolism. Lastly, pharmacological inhibition of ANT …

Doctors Playing Lawyers: Lessons For Professional Regulation In Crisis, Rebecca H. Allensworth

Vanderbilt Law School Faculty Publications

When someone gets in legal trouble in America, their case is almost invariably decided by a lawyer (a judge), lay people (a jury), or a combination of the two. Professional discipline, however, is a giant unexplained exception. In professional discipline matters, accusations of dangerous or incompetent practice are decided, usually in the first instance but always in the last, by state licensing boards composed of other members of the accused’s profession. These licensing boards wield immense power as labor regulatory institutions, covering ten times as many American workers as the minimum wage and more workers than private and public sector …

African American Men’S Perception Of Fear Of A Deadly Encounter With Police During Traffic Stops In Detroit, Delshawn King

Walden Dissertations and Doctoral Studies

This qualitative, phenomenological study is an examination of the fear of deadly encounters during traffic stops as experienced by seven African American men in Detroit. This fear is rooted in the historical context of slavery, where laws permitted the use of force to control African Americans. Using the critical race theory framework, the impact of traffic stops on African American men was explored, including how these encounters contribute to fear, psychological distress, and potential escalation of violence in interactions with law enforcement. The study shows that the fear of police encounters significantly impacts the psychological well-being, trust, and security of …

Disrupting Nrf2-Driven Cancer Biology Through One-Carbon Metabolism Inhibition, Julius Chembo

Arts & Sciences Graduate Student Theses and Dissertations

Cancer remains a leading cause of mortality worldwide, with treatment resistance and recurrence posing major barriers to long-term survival. Despite advancements in targeted therapies, many cancers develop resistance to chemotherapy, radiation, and immunotherapy, significantly limiting their effectiveness. One key driver of therapeutic resistance is nuclear factor erythroid 2-related factor 2 (NFE2L2/NRF2), a transcription factor that regulates antioxidant responses and drug detoxification. While NRF2 protects normal cells from oxidative stress, its aberrant activation in cancer promotes tumor progression, metabolic reprogramming, and resistance to standard treatments. Alarmingly, NRF2 hyperactivation is implicated in some of the most aggressive and refractory malignancies, yet no …

Induced Cd8a Identifies Enhanced Human Nk Cell Il-15-Induced Proliferation And Metabolism And Modulates Nk Cell Activation, Celia Cubitt

Arts & Sciences Graduate Student Theses and Dissertations

Natural Killer (NK) cells are cytotoxic innate lymphoid cells that play an important role in the surveillance and elimination of virally-infected and malignantly-transformed cells. These primary effector functions are achieved by producing cytokines and chemokines which activate and recruit additional immune effectors, as well as direct cytotoxic killing via perforin and granzymes. NK cell function is tightly regulated by a balance of germ-line encoded activating, inhibitory, co-stimulatory, and cytokine receptors expressed at the cell surface. Through these activating and inhibitory receptors, NK cells recognize and kill targets without prior sensitization through the loss of self-identifying molecules such as major histocompatibility …

Mechanisms Of Mll-Rearranged Infant Leukemogenesis, Jonny Mendoza-Castrejon

Arts & Sciences Graduate Student Theses and Dissertations

Infant leukemias arise as either B cell acute lymphoblastic leukemia (B-ALL) or acute myeloid leukemia (AML) and are primarily driven by MLL/KMT2A-rearrangements (MLLr). Prior work has shown that MLLr transform fetal/neonatal hematopoietic progenitors more efficiently than adult progenitors. However, the genetics and epidemiology of MLLr leukemias present an important paradox. MLLr arise during late gestation under conditions that would seemingly favor leukemic transformation (i.e., fetal/neonatal progenitors have high proliferation rates and self-renewal). Furthermore, MLLr infant leukemias require very few cooperating mutations for transformation. Yet congenital leukemias are 10-fold less common than infant leukemias and >100-fold less common than childhood leukemias …

Oxycodone Self-Administration Modulates Ventral Pallidal Neuron Activity And Plasticity, Jessica Tooley

Arts & Sciences Graduate Student Theses and Dissertations

Opioid use disorder is an urgent public health crisis in the United States. Over 800,000 Americans have died from opioid-related overdoses since 2000. Nearly 30% of people who misuse opioids begin with prescription oral opioids, such as oxycodone, and continue misusing to avoid the immediate aversive state of withdrawal and the persistent dysphoria associated with protracted abstinence from opioids. The persistency of these dysphoric symptoms increases the risk of relapse even after long periods of abstinence. Treatment for opioid use disorder currently consists of pharmacological opioid treatment to reduce withdrawal symptoms and behavioral counseling. However, these strategies have significant real-world …

Police Questioning In Hospitals: Custodial Interrogation Or Not?, Jessica Wisowaty

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

Reverse Engineering Of Binary Programs Using Graph Attention Networks, Sai Nikhila Kanigiri

Master's Theses

Understanding the functionality and behavior of binary code is essential for many software engineering tasks, including malware analysis, vulnerability detection, and program optimization. However, automating this process is challenging due to the complexity of machine code and the significant manual effort required from experienced software engineers. In this paper, we present BinGAT (Reverse Engineering of Binary Programs using Graph Attention Networks), a method for classifying binary programs into algorithmic categories using Graph Attention Neural Networks (GNNs) based on their Control-Flow Graphs (CFGs). Given a binary program, BinGAT extracts its CFG through static analysis and transforms the assembly instructions within each …