Digital Commons Network^™

Effect Of Amino Acid Derivatives And Polyphenol Supplementation On Skeletal Muscle Growth In-Vitro And In-Vivo, Gabriella C. Iheanacho

All Theses

Background

Satellite cells (SCs) are myogenic precursor cells that play a crucial role in muscle growth, and their activity can be influenced by nutrient supplementation. Muscle growth can also be stimulated using growth-promoting hormones; however, there are no approved growth hormones for use in sheep in the United States (Qaid & Abdoun, 2022). This limitation highlights a need to identify alternative compounds that would serve as nutrient supplements to enhance muscle growth and thereby improve meat production. Amino acid derivatives such as guanidinoacetic acid (GAA) and 5-hydroxytryptophan (5-HTP), along with the polyphenol quercetin, are naturally derived compounds that have shown …

A Generalizable And Privacy-Preserving Framework For Anomaly Detection In Heterogeneous Iot Environments, Mahshid Rezakhani

All Theses

With the rapid growth of Internet of Things (IoT) devices across various sectors, detecting anomalies in such systems has become increasingly challenging. IoT environments produce diverse and evolving data streams, often lacking labeled examples, which limits the effectiveness of traditional machine learning models. These models typically require frequent retraining and struggle to adapt to new deployment conditions. This thesis proposes a flexible, privacy-aware framework for anomaly detection in multivariate time series data generated by heterogeneous IoT systems. The approach integrates a long short-term memory variational autoencoder (LSTM-VAE) with contrastive learning and adversarial adaptation, enabling the model to generalize across domains, …

Criminal Behavior Responses To Changing Penalties: Estimating The Impact Of Felony Theft Threshold Changes, Ezra R. Simmons

All Theses

This study estimates how criminal behavior changes in response to shifts in felony theft thresholds, contributing to broader evidence on the deterrent effects of criminal penalties. Using detailed incident-level crime reports, this study applies econometric techniques to evaluate how offenders responded to reduced penalties. Analyzed within is California’s Proposition 47, which raised the felony threshold for theft-related offenses from $450 to $950. The results show a significant increase in low-level shoplifting (approximately 21%) and more substantial rises (approximately 24% to 30%) in crimes within the threshold overlap ($450 to $950). Additionally, the value stolen in crimes below the $450 threshold …

A Comparative Study Of Land Use Regulations And Impact On Coastal Estuaries, Mabel W. Dadzie

All Theses

The study presents a mixed method and longitudinal assessment of land cover change, estuarine land loss, and policy implemented to address the past and anticipated estuarine losses in the Cooper River and North and South Santee watershed over the past twenty years. This study uses National Land Cover Dataset from 2001 to 2021, NOAA’s SLR projection data and planning documents from 1990 to 2025 to examine policy evolution among ten major themes. The results illustrate significant changes in land cover, notably the transition of wetlands, agriculture, and forests to developed land, as well as an evident spike in the integration …

The Effect Of Tort Liability For Prescribed Burns On Wildfire Severity: Evidence From Georgia’S 2000 Policy Reform, John Patrick Phillips

All Theses

This paper aims to estimate the effect of Georgia’s shift in its prescribed fire tort liability standard from simple negligence to gross negligence on the area burned by wildfires on privately owned land. In response to wildfire damage, some states in the Southeast relaxed their liability standards, aiming to promote more prescribed burns and to better control future wildfires. Using the variation of these policy changes, I construct difference-in-difference models to estimate the treatment effect of Georgia’s policy change in July 2000, using counties in North and South Carolina as the control group. I stagger my regressions, adding covariates and …

Exploring Commuter Cyclists' Experiences Commuting In And Around Clemson University, Trevor S. Romans

All Theses

Climate change is a global issue, and high rates of automobile usage contribute to substantial social, environmental, and economic issues. One potential partial solution is creating bicycle-friendly communities. Research suggests that bicycle use leads to benefits in physical health, environmental sustainability, economic savings, and social justice. Research supports the roles of infrastructure development, safety policies, and other transportation planning initiatives in increasing bicycling, but less research has been completed about what is needed to develop bicycle-friendly communities. While physical infrastructure affects willingness to commute by bicycle, research suggests that understanding psychological factors and other behavioral aspects is also important for …

Foreword, Madhav Khosla, Jedediah Britton-Purdy

Faculty Scholarship

What is the rule of law, and why does it matter? Scholars have tended to pose this question as a conceptual one: does organizing power and authority by means of law imply certain moral commitments, ways that power should be shaped and constrained?

What Is The Distribution Of National Historical Parks?, Randall K. Johnson

Southern Illinois University Law Journal

In an increasingly polarized nation, which no longer can reach any consensus about what is meant by the term “common good,” it might be wise to extend additional protections to national monuments from executive branch interference. But prior to doing so, the U.S. Congress may want to undertake some additional research work. Such research could build on the existing charge of the National Park Service as well as other interested parties. By doing so, Congress gains insight into whether and how this federal legislature should make greater use of the national historical parks designations.

This article explains, at least in …

Teacher Leadership In Social Studies: The Search For Meaning And Identity, Zachary F. Lawson

Dissertations

This qualitative research study brings together social studies education and teacher leadership. Social studies lacks study in the teacher leader literature. This study aimed to understand whether the disciplinary nature of social studies education influenced the enactment of teacher leadership. This study sought an answer to the central research question: What does it mean to be a social studies teacher leader? Using a hermeneutic phenomenology research design, data were collected through semi-structured interviews across two groups of participants. Seven social studies teacher leaders made up one group, and five social studies teachers without leadership roles comprised the other. Findings indicated …

Tree-Based Differential Item Functioning Detection Methods: Exploring Their Performance In Diverse Measurement Scenarios, Nana Amma Berko Asamoah

Graduate Theses and Dissertations

Despite the availability of numerous methods for detecting differential item functioning (DIF), the continued development and evaluation of innovative, data-driven approaches remains essential. Tree-based methods, in particular, represent a significant advancement in DIF detection. Unlike some traditional techniques, they can simultaneously screen multiple variables for DIF without discretizing continuous variables, and do not require the pre-specification of focal and reference groups; capabilities that are especially valuable in today’s diverse and multifaceted assessment contexts. However, research systematically examining the performance of these methods under realistic measurement conditions is limited. This dissertation, in three simulation studies, critically examines the robustness and practical …

A Grounded Theory Investigation Of The Experiences Of Rehabilitation Administrators, Counselors, And Supervisors Providing Services To Women With Disabilities Experiencing Intimate Partner Violence, Dana Posey

Graduate Theses and Dissertations

Abstract There is a noticeable gap in the literature as it relates to how rehabilitation and disability service providers have worked with women with disabilities who have experienced intimate partner violence. To address the dearth of knowledge, a qualitative grounded theory study was conducted with 12 rehabilitation administrators, counselors, and supervisors regarding their experiences providing services to women with disabilities who have been in or are in an intimate partner violence relationship. Semi-structured interviews were administered, recorded, and transcribed verbatim in an ongoing manner throughout the process. As data was collected, it was analyzed using NVIVO 15, which is a …

The Case Against Finean Essentialism, Miles Thibodeaux

Graduate Theses and Dissertations

In this thesis, I survey, critique, and add to recent arguments against Finean Essentialism: the view that all de re modal facts are metaphysically explained by essences. Arguments against Finean Essentialism generally fall into two categories: (a) Finean Essentialism risks contradicting commonly held views or suppositions, or (b) Finean Essentialism involves an explanatory gap, vicious circularity, or a vicious regress. While the details of the arguments within each category differ significantly, it is useful to group them in this way given the relevant implications they have for one another. I will argue that the proposed critiques from category (a) are …

Effect Of Marination And Storage Time On The Properties And Meat Quality Of Broiler Breast, Mayra Mabel Herrera Rivera

Graduate Theses and Dissertations

Abstract The poultry industry has implemented numerous methods, as marination and aging, to improve meat quality and satisfy consumer demands. Three experiments were developed to assess the effects of vacuum tumble marination and aging on the proteins of chicken breast. These experiments utilized 0.75 % sodium chloride, 0.45 % phosphate, and water in a marinade. In experiment one, 270 fillets were allocated into six treatment groups, each comprising 45 fillets. Six days of storage time were used, marinating and storing the fillets in each group at a temperature of 4°C. Following each day of storage period, the fillets underwent a …

Cultural Vibrations: Student Power, International Exchange, And Black America In Mai 1968, Noah Micheal Roberts

Graduate Theses and Dissertations

Abstract This thesis examines the prominence of Black Americans in the 68’ student movement in France. May 68’ incorporated a diverse and global network of social movements and political organizations, and had a notable connection to the American student movement. Black Americans had formed a large expatriate community in France which overlapped with many of the transnational connections forged by the student movements of 68’. This community was extremely notable in the French public sphere for popular works of literature and music, but its political contributions have been minimized or understudied. By utilizing student accounts, state and organizational records, and …

Evidence On The Quality Of Segment Profit/Loss Disclosures And Its Determinants, Hiba A. Abu Sammour

Graduate Theses and Dissertations

Investors have recently indicated that disclosed descriptions of segment profit/loss measures are useful, but insufficient. Clear and detailed descriptions are essential for helping investors understand the segment profit/loss measure employed, especially since these measures may not align with measures from the consolidated income statement under the “management approach.” To better understand investors’ concerns, I hand-collect data from segment profit/loss disclosures and develop a measure that captures a dimension of disclosure quality specific to this setting: the extent to which segment profit/loss disclosures effectively describe the segment profit/loss measure employed. The measure considers the level of detail provided and the ease …

Host-Virus Interaction Dynamics Using Sulfolobus Spindle-Shaped Virus And Host Sulfolobales System, Yeasin Ahmed

Graduate Theses and Dissertations

The Sulfolobus Spindle-shaped virus (SSV) is among the most studied archaeal viruses, particularly in extreme environments. This virus predominantly infects multiple Crenarchaea from the Sulfolobaceae family. These hosts thrive in extreme environmental conditions, such as sulfuric hot springs, with a pH of 2 to 4 and a temperature of 76-80˚C. Sulfolobales exhibit a wide geographical distribution across volcanic hot springs. The Sulfolobus Spindle-shaped Virus (SSV), encompassing strains such as SSV1 and SSV8, employs a non-lytic replication strategy in hosts belonging to the order Sulfolobales. The SSV-Sulfolobales system can be cultured in liquid and gellan gum solid media. A comprehensive study …

How To Do Things With Little Talking Tubes: Nonideal Speech Acts In The Digital Age, Anthony Holdier

Graduate Theses and Dissertations

In this work, I develop a view about what it means to share a social or conversational context with others, as well as what is normatively entailed by doing so. Working from a broadly Austinian perspective about the moral foundations of language use and how we use words to position ourselves within social space, as well as from a generally Stalnakerian social ontology (demarcating groups by dint of aligned or overlapping sets of commitments), I present three papers demonstrating how nonidealized, ordinary language philosophy can make sense of complex, real-world phenomena. Through analyses of heretical utterances, context collapse, and chatbot …

Child Abuse In Colonial America, Brian Allen

Graduate Masters Theses

Child Abuse in Colonial America is an investigation of the extent to which colonial societies were aware of child abuse and how they responded. Historians often assert that awareness of the problem did not exist in America until the mid-nineteenth century; however, the evidence uncovered suggests that cases of child abuse were recognized during the colonial period and that the societal responses differed widely. Historians of childhood document myriad social, economic, political, religious, and other cultural influences that dictate how children were treated at different times and locations, and this framework is used to interpret why the responses to child …

Cannibalizing The Starving: Poverty And Disability In The Late 19th And Early 20th Century America, Cole M. Hayes

Graduate Masters Theses

Cannibalizing the Starving analyzes how the American ruling class and their institutions perceptually disabled people in poverty alongside the repercussions of this disablement within the late 19^th and early 20^th century. This thesis deploys an anarchist framework of understanding hierarchies, the state, and violence is utilized alongside critical disability studies to understand how disability was socially constructed in the context of poverty. Further, much of the framing involved is from the context of labor or those who could not or did not labor. At the heart of the issue is understanding seemingly innocuous language used to denigrate those …

On The Adaptation Of Latent Dynamics Models, Ryan Missel

Theses

Predicting future states of high-dimensional, partially observed dynamical systems - such as cardiac electrical propagation - is crucial for advancing fields like healthcare and physics. While univariate time-series forecasting is well-explored, high-dimensional time-series forecasting presents unresolved challenges. These challenges include the computational burden of processing high-dimensional data and the difficulty of accessing the system’s underlying dynamics directly. Classical optimization and analytical approaches become impractical as the dimensionality increases, leading to a growing interest in data-driven deep learning models, particularly those based on latent dynamics functions. Latent dynamics models provide an efficient way to map high-dimensional observations into lower-dimensional latent spaces, …

Link Between Adverse Childhood Experiences And Parenting Styles Of African American Fathers, Tatianna P. Johnson

Dissertations

African American fathers may be more susceptible than fathers of other races to having a negative parenting style due to their high levels of adverse childhood experiences (ACEs). ACEs are traumatic experiences during childhood that can affect a person’s mental and physical health, income and adult parenting style. African American adults tend to have experienced multiple levels of ACEs at a higher rate than White and Asian adults (Maguire-Jack et al., 2021). ACEs can lead to adults experiencing higher levels of alcoholism, depression, health-related issues, mental illness, substance use, and academic problems. The purpose of this cross-sectional study was to …

Autophagy Regulates Müller Glial Cell Inflammatory Activation, Teresa A Doggett, Zhenqing Zhou, Sohini Rebba, Jacqueline Unsinger, Philip A Ruzycki, Thomas A Ferguson

2020-Current year OA Pubs

PURPOSE: We tested whether Müller cells utilize autophagy to support immune privilege in the eye.

METHODS: The essential autophagy gene Atg5 was deleted in retinal Müller cells. Inflammation was induced by intravitreal injection of lipopolysaccharide (LPS) that was monitored by hematoxylin and eosin (H&E) staining, immunofluorescent confocal microscopy, and flow cytometry. Single-cell RNA sequencing was performed on retinal Müller cells isolated from control and Atg5-deficient mice. Markers of Müller cell gliosis were assessed, and cytokine production in the eye was measured. Small interfering RNA knockdown techniques were used to examine LPS-induced inflammatory pathways in culture.

RESULTS: We observed increased and …

The Importance Of Imperfect Pre-Clinical Models In Adolescent Idiopathic Scoliosis, Diane S Sepich, Ryan S Gray, Nadav Ahituv, Christina A Gurnett, Jonathan J Rios, Lila Solnica-Krezel, Carol A Wise

2020-Current year OA Pubs

Adolescent idiopathic scoliosis (AIS) is a twisting spinal deformity that occurs in otherwise healthy children at the time of rapid pre-pubescent growth. AIS affects ∼3% of children worldwide and is the most common musculoskeletal diagnosis in pediatric populations, posing a significant physiological, psychosocial and financial burden to patients. Genetic predisposition is a clear and major contributor to AIS, and insights from genomic discoveries are inspiring translational studies ultimately aimed at developing novel diagnostics and therapies. Pre-clinical animal models of AIS are now essential to validate human genetic findings, understand gene-by-environment interactions, and speed etiologic and therapeutic discovery. In this Perspective, …

Human Thalamocortical Structural Connectivity Develops In Line With A Hierarchical Axis Of Cortical Plasticity, Valerie J Sydnor, Deanna M Barch, Et Al.

2020-Current year OA Pubs

Human cortical development follows a hierarchical, sensorimotor-to-association sequence. The brain's capacity to enact this sequence indicates that it relies on unknown mechanisms to regulate regional differences in the timing of cortical maturation. Given evidence from animal systems that thalamic axons mechanistically regulate periods of cortical plasticity, here we evaluate in humans whether the development of structural connections between the thalamus and cortex aligns with cortical maturational heterochronicity. By deriving a new tractography atlas of human thalamic connections and applying it to diffusion data from three youth samples (8-23 years; total n = 2,676), we demonstrate that thalamocortical connectivity matures in …

The Role Of Cleavage And Polyadenylation Spcific Factor 6 (Cpsf6) In Hematopoiesis, Fengxi Ye

Dissertations and Theses (Open Access)

Cleavage and polyadenylation specific factor 6 (Cpsf6) translocation is frequently reported in APLL, which is Acute Promyelocytic Leukemia (APL)-like acute myeloid leukemia (AML) and other types of blood diseases associated with abnormal hematopoiesis. CPSF6 is a subunit of the Cleavage Factor I mammalian (CFIm) complex, which regulates post-transcriptional alternative polyadenylation (APA) of pre-mRNAs. Previous research indicated that Cpsf6 plays an essential role in alternative polyadenylation, development, and tumorigenesis. However, the role of Cpsf6 in hematopoiesis is unknown. Given its roles in APA, development and cancer, we hypothesize that Cpsf6 plays a critical role in hematopoiesis and that its …

An Examination Of Legal Status, Law Enforcement Perception, And Crime Victimization And Reporting Among Hispanic Immigrants, Guadalupe C. Cabrera

Electronic Theses and Dissertations

This study relied on in-depth interviews with naturalized citizens and lawful permanent resident Hispanic immigrants to explore their perceptions of law enforcement and experiences with crime victimization and reporting. Past literature has explained that the absence of legal status may deter crime reporting. We added to this body of work by investigating relationships among legal status, trust, and reporting behaviors. This study finds that direct experiences with law enforcement and acquired knowledge may be a better indicator of law enforcement trust and crime reporting compared to legal status. While most participants expressed trust in law enforcement, others felt neutral due …

Empathetic Differentiated Instruction In Deaf Education: Examining Influencing Factors And Experienced Educator Practices, Laura A. Blackburn

STEMPS Master's Level Projects and Papers

This mixed-methods study investigated how experienced K–12 deaf educators implement empathetic, differentiated instruction (EDI) to support the academic and linguistic needs of deaf students who use American Sign Language (ASL) as their language of learning. Guided by Tracey and Baaki’s instructional design empathy model and grounded in constructivism, the study explored how teachers navigated the tension between standardized, English (sound-based) curriculum demands and the need to make instructional decisions aligned with signed language modalities and responsive to students’ real-time learning needs.

A custom electronic survey was distributed to a national sample of experienced educators, with 19 respondents completing Likert-scale items, …

Low-Level Polarimetric Signatures Of Supercells During Ef3+ Tornado Production, Anthony Noah Began

Department of Earth and Atmospheric Sciences: Dissertations, Theses, and Student Research

Most EF3+ tornadoes are produced by supercells. Understanding of microscale features surrounding intense tornado production remains limited. This research aims to determine commonalities in low-level microphysical processes during intense tornado production via polarimetric radar signature assessment with a Python-based algorithm. Polarimetric variables hypothesized to reflect low-level wind profiles such as the differential reflectivity (Z_DR) arc and the Z_DR–K_DP (specific differential phase) separation vector will be investigated. Supercells which produced EF3+ tornadoes will be examined since these tornadoes pose the highest threat. From 2010 to 2024, the United States recorded approximately 19,100 tornadoes which resulted in …

Educating The New Generation Of Food Scientists Through Innovative Learning Experiences, Karen Andrea Nieto Flores

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Food science provides an opportunity to engage high school students in Science, Technology, Engineering, and Mathematics (STEM) by connecting classroom concepts to real-world applications. Despite the field’s relevance to public health, food safety, sustainability, and innovation, food science remains largely absent from high school curricula, and few students recognize it as a viable STEM pathway. This research addressed this gap by evaluating immersive summer camp experiences and teacher-focused curriculum review as strategies to increase food science awareness and interest among students and educators. A literature review traced the historical development and current landscape of K–12 food science education, identifying barriers …

Functional Genomics Of Phosphatidylcholine Biosynthesis In Saccharomyces Cerevisiae, Amanda Marie Maliva

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Phosphatidylcholine (PtdCho) is a prominent structural building block of cell and organelle membranes in animal, plant, and fungal cells and some bacteria. Due to its abundant nature in the plasma membrane and intracellular organelle membranes in eukaryotes, the biosynthesis of PtdCho must remain regulated to preserve the correct membrane lipid composition. Dysregulations in PtdCho metabolism can lead to mitochondrial dysfunction, cell death, and the development of diseases including cancer, atherosclerosis, and hepatic diseases. Knowledge of PtdCho has remained limited to the genes involved in its three biosynthetic pathways (Kennedy (K), methylation (M), and acyltransferase (A)), despite the growing realization of …