Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Law (362217)
- Social and Behavioral Sciences (129548)
- Arts and Humanities (102067)
- Education (62286)
- Medicine and Health Sciences (39974)
-
- History (35342)
- Life Sciences (35219)
- Constitutional Law (35073)
- Physical Sciences and Mathematics (32521)
- Business (29873)
- Engineering (26605)
- Sociology (24332)
- Communication (22997)
- International Law (22846)
- Religion (21826)
- Criminal Law (20658)
- Higher Education (20094)
- Public Affairs, Public Policy and Public Administration (17591)
- Political Science (17364)
- United States History (15474)
- Psychology (14038)
- Courts (12599)
- Intellectual Property Law (12268)
- Civil Rights and Discrimination (11992)
- Library and Information Science (11553)
- State and Local Government Law (11277)
- Accounting (11247)
- Journalism Studies (11101)
- Environmental Law (10864)
- Comparative and Foreign Law (10809)
- Institution
-
- University of New Mexico (37078)
- Brigham Young University Law School (30174)
- Villanova University Charles Widger School of Law (28406)
- University of Mississippi (21448)
- University of South Florida (19005)
-
- University of Nebraska - Lincoln (18996)
- University of Colorado Law School (16871)
- University of Michigan Law School (16370)
- University of Montana (16148)
- Fordham Law School (13084)
- UC Law SF (12002)
- University of New Hampshire (11538)
- University of Kentucky (11452)
- University of Chicago Law School (10185)
- Southern Methodist University (10150)
- Brigham Young University (9886)
- San Jose State University (9636)
- Louisiana State University (9547)
- Duke Law (9477)
- University of Central Florida (9392)
- UIdaho Law (9228)
- University of Denver (9122)
- William & Mary Law School (9048)
- University of South Carolina (9044)
- Eastern Illinois University (9010)
- University of North Dakota (8916)
- City University of New York (CUNY) (8665)
- Murray State University (8351)
- Maurer School of Law: Indiana University (8092)
- Yeshiva University, Cardozo School of Law (7817)
- Keyword
-
- Newspaper (16162)
- Student newspaper (7470)
- Education (7062)
- History (6824)
- Newspapers (6049)
-
- EIU (5441)
- United States (5397)
- Law (5294)
- Spartan Daily (4490)
- Latin America (4437)
- Humans (4177)
- Bowling Green State University (4051)
- Spanish (4022)
- Pennsylvania (3891)
- Constitutional law (3890)
- University of New Mexico (3841)
- Eastern Illinois University (3831)
- Higher education (3814)
- UNM (3794)
- LADB (3792)
- LAII (3792)
- Latin American and Iberian Institute (3792)
- Daily Eastern News (3758)
- BG News (3696)
- Collegeville (3643)
- Politics (3322)
- Supreme Court (3268)
- N.M. (3259)
- Student newspapers (3187)
- Periodicals (3185)
- Publication Year
-
- 2026 (22500)
- 2025 (30283)
- 2024 (32625)
- 2023 (29164)
- 2022 (32305)
-
- 2021 (32034)
- 2020 (31202)
- 2019 (30715)
- 2018 (31159)
- 2017 (32216)
- 2016 (32922)
- 2015 (32854)
- 2014 (31677)
- 2013 (31567)
- 2012 (33106)
- 2011 (27179)
- 2010 (25837)
- 2009 (24424)
- 2008 (22487)
- 2007 (20263)
- 2006 (20512)
- 2005 (18672)
- 2004 (17680)
- 2003 (15805)
- 2002 (14547)
- 2001 (14533)
- 2000 (13868)
- 1999 (12631)
- 1998 (12790)
- 1992 (12437)
- Publication
-
- Theses and Dissertations (18294)
- Faculty Scholarship (15916)
- Faculty Publications (12443)
- Electronic Theses and Dissertations (10296)
- Articles (10053)
-
- Michigan Law Review (8430)
- Dissertations (7321)
- Idaho Supreme Court Records & Briefs, All (5567)
- Utah Court of Appeals Briefs (1996–2006) (5390)
- Utah Court of Appeals Briefs (through 1995) (5275)
- Walden Dissertations and Doctoral Studies (5177)
- Santa Fe New Mexican, 1883-1913 (5005)
- Utah Supreme Court Briefs (1965 –) (4915)
- Daily Mississippian (all digitized issues) (4788)
- North Carolina Law Review (4554)
- Spartan Daily (School of Journalism and Mass Communications) (4297)
- Fordham Law Review (4280)
- Theses (4250)
- Louisiana Law Review (4178)
- Journal of Criminal Law and Criminology (4145)
- Masters Theses (4116)
- St. John's Law Review (4050)
- Session Laws 2001-Present (4038)
- Montana Kaimin, 1898-present (4027)
- Master's Theses (3979)
- University of Chicago Law Review (3957)
- Denver Law Review (3842)
- BG News (Student Newspaper) (3712)
- Indiana Law Journal (3615)
- Faculty Articles (3483)
- Publication Type
Articles 31921 - 31950 of 1192942
Full-Text Articles in Entire DC Network
Whose Art Is It Anyway? Guidelines For Returning Cultural Property Removed Prior To World War Ii, Amy Bitterman
Whose Art Is It Anyway? Guidelines For Returning Cultural Property Removed Prior To World War Ii, Amy Bitterman
Buffalo Law Review
No abstract provided.
Regulating Algorithmic Accountability In Financial Advising: Rethinking The Sec’S Ai Proposal, Chen Wang
Regulating Algorithmic Accountability In Financial Advising: Rethinking The Sec’S Ai Proposal, Chen Wang
Buffalo Law Review
As artificial intelligence increasingly reshapes financial advising, the SEC has proposed new rules requiring brokerdealers and investment advisers to eliminate or neutralize conflicts of interest arising from AI use. This Article critically assesses the proposal’s scope, rationale, and feasibility, contending that its sweeping definitions and prescriptive mandates risk overregulation and conflict with the SEC’s longstanding disclosure-based regulatory approach. Drawing on case law, fiduciary duties, Regulation Best Interest, and existing antifraud provisions, this Article argues that the current legal framework, grounded in disclosure and informed consent, remains sufficient to manage AI related conflicts. It cautions against imposing categorical conflict elimination requirements …
Climbing Mount Laurel: Federal Land Use And Zoning Policy As The Bipartisan Solution To The Affordable Housing Crisis, Nina Stockman
Climbing Mount Laurel: Federal Land Use And Zoning Policy As The Bipartisan Solution To The Affordable Housing Crisis, Nina Stockman
Buffalo Law Review
No abstract provided.
Shale Investment Dashboard In Ohio Q1 And Q2 2024, Andrew R. Thomas, Mark Henning, Samuel Owusu-Agyemang
Shale Investment Dashboard In Ohio Q1 And Q2 2024, Andrew R. Thomas, Mark Henning, Samuel Owusu-Agyemang
All Maxine Goodman Levin School of Urban Affairs Publications
This report presents findings from an investigation into shale-related investment in Ohio, looking at up, mid, and downstream activities. The investment estimates are for January through June of 2024. The report also includes an estimate of cumulative investment into shale in Ohio from 2012 through June 2024. Prior biannual investments are included in previously posted reports that are available from Cleveland State University.
Alternative Therapeutics For Human Breast Cancer: Nutraceutical Underpinnings, In Vitro Metabolomic Profiling, Treatment Efficacy, And Contextual Ethical Implications, Aubrey A. Mattingly
Alternative Therapeutics For Human Breast Cancer: Nutraceutical Underpinnings, In Vitro Metabolomic Profiling, Treatment Efficacy, And Contextual Ethical Implications, Aubrey A. Mattingly
All Dissertations
Breast cancer remains one of the most prevalent diseases worldwide, yet therapeutic equity is still lacking. Standard treatments including surgery, radiotherapy, chemotherapy, and long-term hormone therapy. These approaches are often accompanied by significant side effects. While newer methods such as immunotherapy and targeted therapies have emerged, chemotherapy protocols and incorporation have remained largely unchanged in the past decades. In this context, nutraceuticals represent an alternative or adjuvant to therapy worthy of exploration. The reviewed literature highlights the anti-carcinogenic activity in selected nutraceuticals, marjoram, thyme and persimmon, considering their phytochemical constituents and secondary metabolites. Metabolomic profiling using the Biolog Phenotype Mammalian …
Coding Manual: Analyzing Semistructured Interview Data For Master Narratives, Jayson Seaman, Cindy Hartman, Andrew D. Coppens
Coding Manual: Analyzing Semistructured Interview Data For Master Narratives, Jayson Seaman, Cindy Hartman, Andrew D. Coppens
Faculty Publications
This coding manual accompanies a methodological reorientation in narrative identity research, one that challenges the field’s prevailing “protagonist bias” — the assumption that first-person autobiographical accounts are the primary or most valid source for identifying cultural master narratives as psychological resources. While much psychological research has centered on how individuals narrate their own lives, this approach can obscure the ways that broader cultural narratives are circulated, reinforced, and contested through discourse beyond the self. This method provides researchers with a systematic approach for identifying how master narratives operate across multiple narrative levels, often outside of biographical storytelling.
Social And Economic Gradients Of Resource Transfer Behavior In Gorongosa, Mozambique, Karl J. Mertens
Social And Economic Gradients Of Resource Transfer Behavior In Gorongosa, Mozambique, Karl J. Mertens
Boise State University Theses and Dissertations
Why do people who experience the same environmental and social conditions vary so much in their resource transfer behavior? This dissertation addresses that question through examination of behavioral variation in subsistence horticulturalists in the dry tropical forest bufer conservation area of Gorongosa National Park in Mozambique. In this region of moderate and acute food shortages at both household and regional levels, individuals face similar challenges of addressing social and resource uncertainty yet respond with marked behavioral variation that cannot be explained solely by diferences in wealth, kinship, or reciprocity patterns.
Using a Behavioral Reaction Norms (Dingemanse et al., 2010) (BRN) …
Aging Effect On Effective Connectivity Within The Prefrontal-Motor Network And Postural-Related Muscle Responses During Dual-Task Paradigms, Jiahao Pan
Boise State University Theses and Dissertations
Falls are a significant global public issue for older adults, leading to severe health and social impacts. To understand the underlying mechanism of increased fall risk with aging, loss of postural automaticity has been suggested as increased prefrontal cortex and motor cortices activation, as well as worse balance performance in response to the secondary cognitive task. However, the interaction within these cortical regions and its effects on postural-related muscle responses are poorly understood. This dissertation investigated age-related changes in effective connectivity within the prefrontal-motor network, postural related lower limb muscle response, and biomechanical characteristics in response to the secondary cognitive …
“I Wish These Damned People Would Stay Put”: The Political Ambivalence Of Us Archaeologists In Guatemala, 1931–1956, Fernando Armstrong-Fumero
“I Wish These Damned People Would Stay Put”: The Political Ambivalence Of Us Archaeologists In Guatemala, 1931–1956, Fernando Armstrong-Fumero
Anthropology: Faculty Publications
This article traces the history of how two generations of US archaeologists navigated their relationship with the Guatemalan government, from the Jorge Ubico dictatorship in the 1930s through the democratic opening of the 1940s and 1950s and the subsequent CIA-sponsored coup. Critiques of modern archaeology have focused on the discipline’s history of ideological and material collusion with different projects of US and European imperialism in the Global South. While the archaeologists discussed here benefited from US hegemony in the region, their own correspondence reflects an ambivalent relationship to formal frameworks of international law and a desire to function as autonomous …
How Do Homeschool Parents In South Carolina Select Curriculum And Make Pedagogical Choices To Support Their Children’S Early Reading Development?, Lauretta O. Osho
How Do Homeschool Parents In South Carolina Select Curriculum And Make Pedagogical Choices To Support Their Children’S Early Reading Development?, Lauretta O. Osho
All Dissertations
Early Childhood Education (ECE) is a period of growth and development for young children as they begin their educational journey. The need for a high-quality early childhood learning experience is necessary for the child’s holistic development, without which children may grow up with learning challenges that could negatively impact their adult life. Each child's early learning experience must begin with a good and deliberate reading foundation. Therefore, understanding the best methods of instilling strong reading skills in children from an early age sets the foundation for lifelong learning and success.
Homeschooling is the practice of educating, instructing, and tutoring children …
An Exploration Of Factors Influencing Sophomore-Year Persistence At A Regional Institution In Southern Appalachia, Jonathan W. Mitchell
An Exploration Of Factors Influencing Sophomore-Year Persistence At A Regional Institution In Southern Appalachia, Jonathan W. Mitchell
Electronic Theses and Dissertations
The purpose of this qualitative and interpretative phenomenological study was to explore factors that participants identified as playing roles in their persistence through their sophomore years at a regional university located within Southern Appalachia. Research on second-year retention efforts is far lacking compared to first-year retention efforts. Reflecting the heavy emphasis placed on the first year, there is also more research on first-year retention. However, students can feel a sharp decline in support entering sophomore year, making that just as critical of a transition. Student retention has been emphasized in higher education since its inception, as an institution’s goal in …
Making Sense Of Myc In Skeletal Muscle, Ronald G. Jones, Sebastian Edman, Nathan Serrano, Yuan Wen, John J. Mccarthy, Christopher S. Fry, Ferdinand Von Walden, Kevin A. Murach
Making Sense Of Myc In Skeletal Muscle, Ronald G. Jones, Sebastian Edman, Nathan Serrano, Yuan Wen, John J. Mccarthy, Christopher S. Fry, Ferdinand Von Walden, Kevin A. Murach
Physiology Faculty Publications
No abstract provided.
The Lived Experiences Of Fathers With Postpartum Depression: A Qualitative Study, Rachael Elizabeth Schmitz
The Lived Experiences Of Fathers With Postpartum Depression: A Qualitative Study, Rachael Elizabeth Schmitz
Nursing and Health Sciences
Background:
Although parents may joyfully anticipate the birth of a child, it's impossible for them to know ahead of time just how profoundly their lives will change. Postpartum depression (PPD) can result. While there is a substantial body of research regarding maternal PPD, paternal PPD has received far less attention and is neither adequately understood nor diagnosed. This is exacerbated by outdated but persistent sociocultural masculinity norms and the stigmas around mental health issues.
Purpose:
This study sought to explore the lived experiences of new fathers with PPD in order to provide greater insight into their experiences.
Methods:
This qualitative …
Autonomous, Yet Anchored: Exploring The Interplay Of Self-Reliance And Personal Spirituality On Employee Outcomes, Alexander Schad
Autonomous, Yet Anchored: Exploring The Interplay Of Self-Reliance And Personal Spirituality On Employee Outcomes, Alexander Schad
All Dissertations
The modern workplace increasingly requires employees to function autonomously while managing limited psychological resources, presenting a tension between the benefits of self-reliance and its potential costs to well-being. This dissertation examined how self-reliance simultaneously influences task persistence and emotional exhaustion, and explores whether personal spirituality moderates these relationships. Drawing on the Strength Model of Self-Control (SMSC), I develop and test a theoretical framework investigating the relationships between self-reliance, work overload, task persistence, emotional exhaustion, and workplace spirituality.
Through a time-lagged field study with 453 working professionals across three measurement waves, I found that self-reliance positively predicted task persistence, supporting the …
Student Handbook 2025-2026, Saint Mary's College Of California
Student Handbook 2025-2026, Saint Mary's College Of California
Student Handbook
No abstract provided.
Self-Poled P(Vdf-Trfe) Based Composites For Energy Harvesting And Wearable Sensor Applications, Lavanya Muthusamy
Self-Poled P(Vdf-Trfe) Based Composites For Energy Harvesting And Wearable Sensor Applications, Lavanya Muthusamy
All Dissertations
The growing demand for flexible, low-power, and self-powered wearable electronic systems has accelerated research interest in polymer-based sensors and energy harvesting technologies. Among piezoelectric polymer materials, Poly(vinylidene fluoride-trifluoro ethylene) [P(VDF-TrFE)], over the years, has garnered significant attention due to its unique piezoelectric properties, high dielectric constant, mechanical flexibility, thermal stability, chemical resistance, biocompatibility and compatibility with scalable fabrication processes. Despite its advantages, conventional P(VDF-TrFE)-based devices often require external poling and face limitations in integration with low-cost, flexible substrates. To overcome these limitations, this research study explores the nanofiller approach, along with facile fabrication processes, and structural design strategies aimed at …
27th Annual Open Government Summit: Your Guide To The Access To Public Records Act & Open Meetings Act (Powerpoint Slides) 08-01-2025, Attorney General State Of Rhode Island
27th Annual Open Government Summit: Your Guide To The Access To Public Records Act & Open Meetings Act (Powerpoint Slides) 08-01-2025, Attorney General State Of Rhode Island
School of Law Conferences, Lectures & Events
No abstract provided.
27th Annual Open Government Summit: Your Guide To The Access To Public Records Act & Open Meetings Act 08-01-2025, Attorney General State Of Rhode Island
27th Annual Open Government Summit: Your Guide To The Access To Public Records Act & Open Meetings Act 08-01-2025, Attorney General State Of Rhode Island
School of Law Conferences, Lectures & Events
No abstract provided.
Madam President: Navigating The Journey Of Black Women To Executive Leadership In Higher Education, Tressi Daymon
Madam President: Navigating The Journey Of Black Women To Executive Leadership In Higher Education, Tressi Daymon
Education Doctoral
The purpose of this phenomenological qualitative study is to examine the leadership trajectories of Black women in senior executive roles in higher education, with a focus on the barriers and supports that have shaped their careers. Semi-structured interviews gathered perspectives on their lived experiences, capturing both the challenges they faced and the strategies used in their journeys. These strategies included networking, skill-building, advocacy, and resilience, reflecting how these women navigated and overcame the unique leadership challenges they faced. Black feminist theory and intersectionality provided the theoretical framework to explore how race and gender biases uniquely affected their leadership journeys. Data …
Comparative Analysis Of E-Government Adoption And Implementation In Selected Countries In Africa, The Americas, Europe, Asia, And Oceania., Anthony O. Emukah
Comparative Analysis Of E-Government Adoption And Implementation In Selected Countries In Africa, The Americas, Europe, Asia, And Oceania., Anthony O. Emukah
LSU New Orleans Theses and Dissertations
No abstract provided.
Analysis Of The Scleroderma / Systemic Sclerosis Etiopathology Using The University Of California At Davis (Ucd)-Ssc Chicken Line, Angeline E. Rodriguez
Analysis Of The Scleroderma / Systemic Sclerosis Etiopathology Using The University Of California At Davis (Ucd)-Ssc Chicken Line, Angeline E. Rodriguez
Graduate Theses and Dissertations
Scleroderma/Systemic Sclerosis (SSc) is a multifaceted autoimmune disorder affecting approximately 300,000 people in the United States. Main features include vasculitis, immune dysfunction (innate and adaptive), autoantibody production, perivascular leukocyte infiltration, and extensive tissue fibrosis. The University of California, Davis (UCD) SSc chicken line was shown to exhibit all clinical and biological manifestations of human SSc. One early and distinctive clinical sign in both humans and UCD-SSc chickens is Raynaud’s phenomenon (RP), characterized by decreased blood flow in extremities and skin lesions. RP-like lesions develop in combs of UCD-SSc chickens within one- to two-weeks post-hatch, progressing from erythema and edema to …
Issue 2 - Arete Newsletter - 2025, Liberty University
Caste Formalism: The Law And Politics Of Equality In India, Madhav Khosla, Pratap Bhanu Mehta
Caste Formalism: The Law And Politics Of Equality In India, Madhav Khosla, Pratap Bhanu Mehta
Faculty Scholarship
In modern constitutional democracies, achieving equality has long been a challenge. In recent years, theorists have focused on understanding the meaning of discrimination and determining when and how discrimination becomes problematic. One critical issue that has long animated discussions on both the general guarantee of equality and the specific goals of anti-discrimination law is the relationship between individuals and groups. If a constitutional order aims to take equality seriously, how should it address the experiences of specific groups historically subjected to discrimination? Indeed, questions of equality and discrimination often converge around the issue of affirmative action, sometimes at the expense …
Correcting Antitrust Monopsony Theory And Addressing Anticompetitive Conduct In Low-Skill Labor Markets, Grimes, Warren
Correcting Antitrust Monopsony Theory And Addressing Anticompetitive Conduct In Low-Skill Labor Markets, Grimes, Warren
Santa Clara Law Review
Addressing growing income inequality in the United States should begin with the plight of low-skilled workers, many subject to below subsistence income and stressful and dangerous working conditions. Antitrust cannot offer a comprehensive solution to this problem. It can, however, meaningfully contribute to a solution in two ways. The first is to adjust the classic definition of monopsony to address the special conditions that apply to unskilled labor markets and to clear away obstacles to meritorious antitrust claims. Under classic theory, a monopsonist lowers input prices causing some input providers to stop supplying. That premise, while it may hold for …
Factors Associated With Farm Service Agency Direct Farm Ownership Loan Delinquency, Mohammad Ismile Hossain
Factors Associated With Farm Service Agency Direct Farm Ownership Loan Delinquency, Mohammad Ismile Hossain
Graduate Theses and Dissertations
This thesis investigates the factors associated with loan defaults in the USDA's Direct Farm Ownership (FO) loan program, emphasizing factors that affect how long it takes to default. This study uses a Cox Proportional Hazards model on a dataset of more than 47,000 loan records originated during 2011-2020 to identify loan characteristics, financial factors, and geographic settings related to the likelihood and timing of delinquency, which is defined as being 90 days past due. Recent research has focused on differences in loan outcomes based on demographics. This study, on the other hand, focuses on loan size, interest rates and terms, …
Using Inquiry Classroom Experiences To Correct Student Misconceptions In Elementary Science: An Action Research Study, Hope A. Ellison
Using Inquiry Classroom Experiences To Correct Student Misconceptions In Elementary Science: An Action Research Study, Hope A. Ellison
Master's Theses
Misconceptions in elementary science education can significantly hinder students' ability to construct accurate and lasting conceptual understandings. Grounded in the constructivist learning theory, this quasi-experimental study investigates how inquiry-based instruction influences the identification and correction of third-grade students’ misconceptions in science, specifically in the domains of energy, force, and matter. Using a pre- and post-test design, along with data derived from daily teacher field notes, the research was conducted with a sample of fifteen third-grade students at a public elementary school in Mississippi. The results, discussed in the methods section, revealed a statistically significant improvement in students’ conceptual understanding following …
Trust Across Difference In Radical Social Movement Organizations: The Case Of The Student Nonviolent Coordinating Committee, Kerstin Miller
Trust Across Difference In Radical Social Movement Organizations: The Case Of The Student Nonviolent Coordinating Committee, Kerstin Miller
Master's Theses
Social movement literature does not properly address trust between activists as a foundation of social movement organizations. This thesis aims to fill that gap by examining how trust within the Student Nonviolent Coordinating Committee, a radical civil rights organization in the sixties, was built and broken over the course of the decade. I drew on first-hand accounts written by SNCC activists to find patterns in how they thought about trust building and trust breaking in their own organization. I found that trust was built primarily through sustained interaction between activists, and that trust in the organization led to activists being …
Multicenter Span Trial Of Fasudil In Ischemic Stroke, Takahiko Imai, Andreia Lopes De Morais, Xuyan Jin, Tao Qin, Jessica Lamb, Karisma A Nagarkatti, Mu-Hsun Chen, Ligia S B Boisserand, Rakesh B Patel, Mariia Kumskova, Anjali Chauhan, Krishnan M Dhandapani, Mohammad B Khan, Pradip K Kamat, Yanrong Shi, Suyi Cao, Basavaraju G Sanganahalli, Joseph B Mandeville, Patrick D Lyden, David C Hess, Enrique C Leira, Anil K Chauhan, Jaroslaw Aronowski, Louise D Mccullough, Raymond C Koehler, Lauren H Sansing, Márcio A Diniz, Cenk Ayata
Multicenter Span Trial Of Fasudil In Ischemic Stroke, Takahiko Imai, Andreia Lopes De Morais, Xuyan Jin, Tao Qin, Jessica Lamb, Karisma A Nagarkatti, Mu-Hsun Chen, Ligia S B Boisserand, Rakesh B Patel, Mariia Kumskova, Anjali Chauhan, Krishnan M Dhandapani, Mohammad B Khan, Pradip K Kamat, Yanrong Shi, Suyi Cao, Basavaraju G Sanganahalli, Joseph B Mandeville, Patrick D Lyden, David C Hess, Enrique C Leira, Anil K Chauhan, Jaroslaw Aronowski, Louise D Mccullough, Raymond C Koehler, Lauren H Sansing, Márcio A Diniz, Cenk Ayata
Children’s Nutrition Research Center Staff Publications
Background: The SPAN (Stroke Preclinical Assessment Network) is a confirmatory multicenter trial network to test cerebroprotective interventions in experimental acute stroke. In a first-of-its-kind trial, SPAN tested 6 interventions in a rodent model of transient focal ischemic stroke. Here, we report the efficacy of fasudil, an isoform-nonselective rho-associated kinase inhibitor, on primary and secondary outcomes in the SPAN trial.
Methods: Fasudil was administered at 10 mg/kg intraperitoneally every 12 hours for 6 doses starting 5 minutes before reperfusion in a 60-minute endovascular filament middle cerebral artery occlusion model. The active treatment arm (n=345) was compared with the pooled intraperitoneal and …
Human Salivary Gland Stem/Progenitor Cells For Tissue Engineering, Sars-Cov-2 Susceptibility, And Neurointegration, Caitlynn Barrows
Human Salivary Gland Stem/Progenitor Cells For Tissue Engineering, Sars-Cov-2 Susceptibility, And Neurointegration, Caitlynn Barrows
Dissertations and Theses (Open Access)
Salivary glands and the saliva they secrete are important for digestion, chewing, and maintaining oral health. Reduced saliva production leads to a decreased quality of life for patients experiencing hyposalivation as a result of disease or injury, thus a large effort has been dedicated to developing materials and medium to recapitulate the structure of the gland for regenerative medicine. In doing so, we have come closer to developing a more complex model to study disease. These models, however, do not yet fully recapitulate the gland. In this dissertation, we describe a new cell source that can be used to develop …
Clonal Phenotype Mapping Reveals Genomic Alterations Underlying Tumor Immunosuppression During Immunotherapy, Er-Yen Yen
Clonal Phenotype Mapping Reveals Genomic Alterations Underlying Tumor Immunosuppression During Immunotherapy, Er-Yen Yen
Dissertations and Theses (Open Access)
Tumors are dynamic ecosystems that evolve under selective pressures, shaping their ability to either elicit or evade immune responses. In pancreatic ductal adenocarcinoma (PDAC), where immunotherapy has yet to become an effective treatment option, we investigated the role of intratumoral heterogeneity in influencing immune interactions. Using orthotopic clonal replica tumors, we tracked clonal dynamics in response to anti-PD1 therapy and found that while treatment had limited impact on overall tumor volume, it induced profound shifts in clonal composition. Spatial lineage analysis of treatment-naïve tumors revealed that clones with distinct immunotherapy sensitivities occupy unique tumor microenvironments, a pattern that remained stable …