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Mapping The Evidence Base Of Kidney, Prostate And Urinary Tract Tumours To Inform The Who Classification Of Tumours, Sophie Gruber, Karolina Worf, Inga Trulson, Laura Knoblauch, Tobias Gruber, Kirstina Schwamborn, Fiona Campbell, Richard Colling, Alex Inskip, Elena Plans-Beriso, Oana M. Craciun, Magdalena Chechlińska, Magdalena Kowalewska, Kateryna Maslova, Puay Hoon Tan, Harshima Wijesinghe, Ian A. Cree, Dilani Lokuhetty, Blanca Iciar Indave Ruiz, Stefan Holdenrieder Jun 2026

Mapping The Evidence Base Of Kidney, Prostate And Urinary Tract Tumours To Inform The Who Classification Of Tumours, Sophie Gruber, Karolina Worf, Inga Trulson, Laura Knoblauch, Tobias Gruber, Kirstina Schwamborn, Fiona Campbell, Richard Colling, Alex Inskip, Elena Plans-Beriso, Oana M. Craciun, Magdalena Chechlińska, Magdalena Kowalewska, Kateryna Maslova, Puay Hoon Tan, Harshima Wijesinghe, Ian A. Cree, Dilani Lokuhetty, Blanca Iciar Indave Ruiz, Stefan Holdenrieder

Peninsula Medical School

BackgroundThe project ‘World Health Organization (WHO) Classification of Tumours (WCT): a Living Evidence Gap Map by Tumour Type’ applies the Evidence and Gap Map (EGM) methodology to systematically synthesise evidence to support iterative refinements of the WCT. As part of this work, we created the first EGM for the WCT of Urinary and Male Genital Tumors, covering clear cell renal cell carcinoma, non-clear cell renal cell carcinoma, glandular neoplasms of the prostate and urothelial tumours.MethodsSystematic searches in PubMed and Ovid Embase were conducted and harmonised to a 2020 to 2024 publication time period. Following title and abstract screening, reviewers coded …

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Towards Balanced Legislation For Achieving Development And Attracting Investments In Syria: A Comparative Study, Maisoon Abdulwahab Al-Masri, Jaffar Al-Khair, Ebaa Hendy Jun 2026

Towards Balanced Legislation For Achieving Development And Attracting Investments In Syria: A Comparative Study, Maisoon Abdulwahab Al-Masri, Jaffar Al-Khair, Ebaa Hendy

Sultan Qaboos University Legal Studies Journal

Law constitutes a fundamental instrument for regulating economic activity and establishing a stable and secure investment environment that enhances investor’s confidence and encourages the inflow of capital. The importance of this framework is particularly pronounced in Syria, where the post-conflict reconstruction phase represents a strategic challenge requiring investment volumes that exceed domestic capacity, thereby rendering foreign financing an urgent necessity. In this context, Investment Law No. 18 of 2021 and Presidential Decree No. 114 of 2025 constitute a pivotal step toward simplifying procedures, expanding investment incentives, and strengthening investor protection in line with international standards, while also underscoring the effectiveness …

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Glucose-Lowering Effects Of Epigallocatechin Gallate And Metformin In Diabetic Zebrafish Models: A Systematic Review And Meta-Analysis, Dinda Ayu Permatasari, Abdul Khairul Rizki Purba, Maftuchah Rochmanti, Rizky Alvian Adi Kurniawan, Shilvi Haliza Pratiwi Jun 2026

Glucose-Lowering Effects Of Epigallocatechin Gallate And Metformin In Diabetic Zebrafish Models: A Systematic Review And Meta-Analysis, Dinda Ayu Permatasari, Abdul Khairul Rizki Purba, Maftuchah Rochmanti, Rizky Alvian Adi Kurniawan, Shilvi Haliza Pratiwi

Folia Medica Indonesiana

Metformin is widely recognized as an effective glucose-lowering agent for type 2 diabetes mellitus, while epigallocatechin gallate (EGCG) has exhibited promising antidiabetic and antioxidant properties in experimental settings. This systematic review and meta-analysis aimed to assess the impact of EGCG and metformin on blood glucose concentrations in diabetic zebrafish models and to synthesize the related metabolic and mechanistic findings. The protocol was registered with PROSPERO (CRD420261461237) and the review was conducted in accordance with PRISMA 2020 guidelines. Comprehensive searches were performed in PubMed/MEDLINE, Scopus, Web of Science, and Embase for in vivo zebrafish studies published from January 2010 to August …

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Barley Virtual Water Determinants In Iraq: An Econometric Analysis Study For The Period (1990–2023), Muna Jabbar Rahim, Basim H. Al-Badri Jun 2026

Barley Virtual Water Determinants In Iraq: An Econometric Analysis Study For The Period (1990–2023), Muna Jabbar Rahim, Basim H. Al-Badri

Journal of Economics and Administrative Sciences

The paper aims to analyze the determinants of virtual water use for barley crops in Iraq over the period (1990–2023), in light of increasing water challenges and declining inflows of the Tigris and Euphrates Rivers. The research adopts a descriptive and econometric analytical approach, employing the Autoregressive Distributed Lag (ARDL) model to examine the relationship between imported virtual water quantity (VW) as the dependent variable and a set of independent variables, including agricultural GDP, blue water, the water self-sufficiency ratio, and the degree of agricultural trade openness. The results of the Bounds Test indicate the existence of a long-run equilibrium …

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The Impact Of Technological Empowerment On The Strategic Readiness Of Private Universities: The Mediating Role Of Digital Transformation, Rami Fouad Ahmed Al-Sheikhli, Mustafa Mahmoud Al-Somaidaee Jun 2026

The Impact Of Technological Empowerment On The Strategic Readiness Of Private Universities: The Mediating Role Of Digital Transformation, Rami Fouad Ahmed Al-Sheikhli, Mustafa Mahmoud Al-Somaidaee

Journal of Economics and Administrative Sciences

In the context of the Fourth Industrial Revolution, technological empowerment has become a strategic and existential necessity for organizations striving for growth and continued competitiveness, particularly private universities, which face significant challenges in comprehensive digital transformation. Literature reveals the absence of an integrated model linking the three research variables (technological empowerment, strategic readiness, and digital transformation). This paper aimed to examine the mediating role of digital transformation in the impact of technological empowerment on strategic readiness in Iraqi private universities. The study has employed a descriptive analytical approach, utilizing a questionnaire as the primary data collection tool. The questionnaire was …

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Natural Radioactivity And Radiological Hazards In Sediments From The Lindi Coast, Indian Ocean, Tanzania, Viator Mujuni, Innocent J. Lugendo Jun 2026

Natural Radioactivity And Radiological Hazards In Sediments From The Lindi Coast, Indian Ocean, Tanzania, Viator Mujuni, Innocent J. Lugendo

Tanzania Journal of Science

The Lindi coast of the Indian Ocean, located in southeastern Tanzania, supports rich biodiversity and has recently experienced rapid growth in socio-economic activities such as fishing, mining, and oil and gas exploration. These activities may enhance levels of natural radioactivity in coastal sediments, potentially increasing radiation exposure to local populations. Therefore, monitoring radioactivity levels and estimating associated radiation doses in this region is important. In this study, thirty-six sediment samples were collected from twelve locations along the Lindi coast and analysed for naturally occurring radionuclides using high-purity germanium (HPGe) gamma-ray spectrometry. The activity concentrations of 226Ra, 232Th, and …

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Anthropology 230 "Culture And Crime": Syllabus, Assignments And Brightspace Quiz Files, Eliza Darling Jun 2026

Anthropology 230 "Culture And Crime": Syllabus, Assignments And Brightspace Quiz Files, Eliza Darling

Open Educational Resources

As part of a project to convert online asynchronous sections in John Jay’s fully online program to OER, Dr. Eliza Darling compiled all of her materials for a 200-level anthropology course, “Culture and Crime,” into a single PDF that can be easily converted to other file types. The assignments and lessons make frequent use of open pedagogical principles. Dr. Darling has also included 14 quizzes as ZIP files that can be imported directly into any LMS, including Brightspace, Canvas, and Blackboard. Because these quizzes are already packaged for LMS import, instructors can add them directly to a course shell without …

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Syarat Usia Presiden Dan Wakil Presiden Dalam Perspektif Konstitusi Dan Konstitusionalisme: Makna Dan Kriteria, Ardhes Blandhivay Leuanan, Mei Susanto Jun 2026

Syarat Usia Presiden Dan Wakil Presiden Dalam Perspektif Konstitusi Dan Konstitusionalisme: Makna Dan Kriteria, Ardhes Blandhivay Leuanan, Mei Susanto

Jurnal Konstitusi & Demokrasi

In order to investigate the inconsistent interpretations of the Constitutional Court regarding the age requirements for presidential and vice-presidential candidates, this study will analyze the dynamics of determining age requirements from the perspective of the 1945 Constitution and the principles of constitutionalism. A socio-legal approach is used in the normative research method to analyze the Constitutional Court's decisions in light of the social and political factors that shaped them. According to the results, Constitutional Court Ruling No. 90/PUU-XXI/2023 marks a turning point in the evolution of Indonesian constitutional law. Initially, there was no strict interpretation of the age limits for …

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Penolakan Penghapusan Kolom Agama Pada Kartu Tanda Penduduk: Krítík Terhadap Putusan Mahkamah Konstitusi Nomor 146/Puu-Xxii/2024, Krisna Bagas Purwopangestu, Nicholas Gerard Felix Simeone Jun 2026

Penolakan Penghapusan Kolom Agama Pada Kartu Tanda Penduduk: Krítík Terhadap Putusan Mahkamah Konstitusi Nomor 146/Puu-Xxii/2024, Krisna Bagas Purwopangestu, Nicholas Gerard Felix Simeone

Jurnal Konstitusi & Demokrasi

This article examines the Constítutíonal Court (MK) Decisíon No. 146/PUU–XXII/2024 which rejected the request to delete the religion column on the Identity Card (KTP). The Decision affirms that every Indonesian citizen must declare their religion or belief in God as expected by Pancasila and the constitutional mandate. The Constitutional Court stated that “not having a religion or belief in God cannot be considered as freedom of religion”. The Constitutional Court Decision has revived the dispute on the urgency of including religion identity on the KTP, especially about the relation between administrative requirements, the legal system of Indonesia, and protection of …

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Reorientasi Kebijakan Pelindungan Anak Terhadap Adiksi Internet Dalam Perspektif Pemenuhan Hak Konstitusional Di Indonesia, I Kadek Agus Aditya Firmantara, Bagus Hermanto Jun 2026

Reorientasi Kebijakan Pelindungan Anak Terhadap Adiksi Internet Dalam Perspektif Pemenuhan Hak Konstitusional Di Indonesia, I Kadek Agus Aditya Firmantara, Bagus Hermanto

Jurnal Konstitusi & Demokrasi

This article examines the paradigm shift in child protection policy in the digital environment through Government Regulation Number 17 of 2025 concerning the Governance of Electronic System Providers for Child Protection (PP TUNAS) from the perspective of fulfilling children's constitutional rights in Indonesia. The study is motivated by the increasing use of the internet by children, which not only exposes them to risks such as harmful content, sexual exploitation, and misuse of personal data, but also creates the risk of internet addiction that may adversely affect children's health, education, and overall development. Despite these concerns, internet addiction has not been …

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ความรับผิดทางอาญาของนิติบุคคลในประเทศฝรั่งเศส: วิวัฒนาการและความสำคัญทางหลักกฎหมายของแนวคิด “Personnes Morales” (Corporate Criminal Liability In France: The Evolution And Jurisprudential Significance Of The Personnes Morales Concept), Rose Charmette Jun 2026

ความรับผิดทางอาญาของนิติบุคคลในประเทศฝรั่งเศส: วิวัฒนาการและความสำคัญทางหลักกฎหมายของแนวคิด “Personnes Morales” (Corporate Criminal Liability In France: The Evolution And Jurisprudential Significance Of The Personnes Morales Concept), Rose Charmette

Chulalongkorn University Law Journal

บทความนี้ศึกษาวิวัฒนาการของความรับผิดทางอาญาของนิติบุคคลในประเทศฝรั่งเศสผ่านแนวคิด personnes morales ซึ่งบัญญัติไว้ในมาตรา 121-2 แห่งประมวลกฎหมายอาญาฝรั่งเศส โดยศึกษาแนวคิดนี้ภายใต้กรอบของความรับผิดของนิติบุคคลต่ออาชญากรรมร้ายแรง โดยเฉพาะอย่างยิ่งในบริบทของกฎหมายอาญาระหว่างประเทศ ซึ่งโดยหลักแล้วกำหนดความรับผิดแก่บุคคลธรรมดาเท่านั้น คำถามวิจัยหลักของการศึกษานี้คือ แนวคิด personnes morales ของฝรั่งเศสช่วยอุดช่องว่างของความรับผิดทางอาญาในกรณีที่นิติบุคคลได้เข้ามามีส่วนร่วมในการกระทำความผิดอาญาร้ายแรงตามธรรมนูญกรุงโรมได้หรือไม่ และแนวคิดนี้สามารถนำมาใช้กับความรับผิดทางอาญาระหว่างประเทศได้เพียงใด บทความได้วิเคราะห์คดีสำคัญ เช่น คดีอื้อฉาวทางเภสัชกรรม Mediator คดี Lafarge S.A. ในซีเรีย และคำพิพากษา Association Sportive ซึ่งตัดสินโดยศาลอาญาของฝรั่งเศส โดยที่ศาลได้วางหลักเกี่ยวกับเจตนาของนิติบุคคล (corporate mens rea) ผสมผสานกับความรับผิดโดยอาศัยการเป็นตัวแทนและความรับผิดโดยอิสระขององค์กร รวมถึงวิธีที่ศาลฝรั่งเศสบังคับใช้บทลงโทษกับนิติบุคคลได้อย่างมีประสิทธิภาพ นอกจากนี้ ยังมีการอ้างอิงเปรียบเทียบกับสหราชอาณาจักรและสวีเดนเพื่อแสดงให้เห็นแนวทางทางเลือกอื่น ๆ และเน้นย้ำว่าระบบฝรั่งเศสมีส่วนช่วยในการพัฒนาแนวคิดความรับผิดทางอาญาของนิติบุคคลอย่างไร ท้ายที่สุด บทความนี้ชี้ให้เห็นว่าหลักคำสอนของ personnes morales ไม่เพียงแต่เป็นกรอบแนวคิดเชิงปฏิบัติเท่านั้น แต่ยังเป็นแนวทางเชิงทฤษฎีที่สามารถแก้ไขปัญหาช่องว่างของความรับผิดในกฎหมายอาญาระหว่างประเทศได้และเสนอข้อคิดสำคัญสำหรับการปฏิรูปในอนาคตเพื่อเสริมสร้างความรับผิดชอบของภาคธุรกิจในระดับข้ามเขตอำนาจศาล

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การบังคับใช้กฎหมายว่าด้วยหนี้ในทางปฏิบัติให้เสร็จสิ้นครบถ้วนตามกระบวนการแห่งกฎหมายวิธีพิจารณาความแพ่ง (Practical Enforcement Of The Law Of Obligations: Ensuring Complete Execution Under The Civil Procedure Law), Jutaporn Chaidejsuriya Jun 2026

การบังคับใช้กฎหมายว่าด้วยหนี้ในทางปฏิบัติให้เสร็จสิ้นครบถ้วนตามกระบวนการแห่งกฎหมายวิธีพิจารณาความแพ่ง (Practical Enforcement Of The Law Of Obligations: Ensuring Complete Execution Under The Civil Procedure Law), Jutaporn Chaidejsuriya

Chulalongkorn University Law Journal

บทความวิจัยนี้มุ่งศึกษาความสัมพันธ์ระหว่างหลักกฎหมายว่าด้วยหนี้ตามประมวลกฎหมายแพ่งและพาณิชย์ กับหลักเกณฑ์การเสนอคดีตามประมวลกฎหมายวิธีพิจารณาความแพ่ง อันเป็นกลไกสำคัญในการบังคับใช้สิทธิของเจ้าหนี้ในทางปฏิบัติ เนื่องจาก “หนี้” เป็นบุคคลสิทธิ เจ้าหนี้จึงไม่อาจบังคับชำระหนี้ได้ด้วยตนเอง แต่ต้องเสนอคดีต่อศาลเพื่อบังคับให้ชำระหนี้ การวิจัยนี้เป็นการวิจัยเชิงหลักกฎหมาย (Doctrinal Legal Research) โดยวิเคราะห์ประเด็นสำคัญเกี่ยวกับหนี้ 7 ประการ ได้แก่ การบอกกล่าวลูกหนี้กับอำนาจฟ้อง การบังคับชำระหนี้ การเรียกดอกเบี้ยกรณีลูกหนี้ผิดนัด การใช้สิทธิเรียกร้องของลูกหนี้ การโอนสิทธิเรียกร้อง การเพิกถอนการฉ้อฉล และอายุความบังคับจำนอง ทั้งนี้ ผู้วิจัยได้จำแนกบทบัญญัติว่าด้วยหนี้ออกเป็น 3 ประเภท ได้แก่ (1) บทบัญญัติที่มีเนื้อหาไม่ครอบคลุมเกี่ยวกับการเสนอคดี (2) บทบัญญัติที่กำหนดวิธีไว้แต่ไม่ครบถ้วนหรือมีปัญหาในการตีความ และ (3) บทบัญญัติที่ไม่สอดคล้องกับกฎหมายวิธีพิจารณาความแพ่ง แล้วนำมาวิเคราะห์เชื่อมโยงกับบทบัญญัติในประมวลกฎหมายวิธีพิจารณาความแพ่ง รวมถึงศึกษาจากตำราและแนวคำพิพากษาศาลฎีกา ผลการศึกษาพบว่า การบังคับใช้กฎหมายว่าด้วยหนี้ให้มีประสิทธิภาพ จำเป็นต้องตีความและบังคับใช้สอดคล้องกับกฎหมายวิธีพิจารณาความแพ่ง ซึ่งผลลัพธ์ของงานวิจัยนี้จะช่วยลดปัญหาทางปฏิบัติและเสริมสร้างความเข้าใจที่ถูกต้องแก่ผู้ศึกษากฎหมายและผู้ปฏิบัติงานในคดีแพ่ง

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Institutionalizing Public Consultation In Thai Health Legislation: Lessons From Ria And Pls Practices, Stithorn Thananithichot, Wichuda Satidporn, Chompunoot Tangthavorn Jun 2026

Institutionalizing Public Consultation In Thai Health Legislation: Lessons From Ria And Pls Practices, Stithorn Thananithichot, Wichuda Satidporn, Chompunoot Tangthavorn

Asia-Pacific Social Science Review

Public consultation is increasingly recognized as a cornerstone of democratic governance, yet its institutionalization in middle-income democracies such as Thailand remains uneven. Although the 2017 Constitution and the 2019 Act on Legislative Drafting and Legal Evaluation mandate participatory processes through Regulatory Impact Assessment (RIA) and Post-Legislative Scrutiny (PLS), implementation has often remained procedural rather than substantive. This study examines how consultation practices operate within Thailand’s public health legislation, a policy domain characterized by significant distributive and ethical implications. Using a qualitative comparative case study design, the research analyzes three legislative processes: the National Health Security Act B.E. 2545 (2002), the …

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Framing China In Conflict Reporting: A Critical Discourse Analysis Of Transitivity In Chinese And Western Media, Tingting Geng, Hongmei Tang Jun 2026

Framing China In Conflict Reporting: A Critical Discourse Analysis Of Transitivity In Chinese And Western Media, Tingting Geng, Hongmei Tang

Journal of English and Applied Linguistics

This study employs a corpus-based critical discourse analysis (CDA) grounded in Halliday’s transitivity framework to investigate how China’s diplomatic stance is discursively constructed within conflict reporting. Focusing on media coverage of the Russian-Ukrainian War and the Palestinian-Israeli Conflict (2023), the study investigates how Chinese and Western mainstream media depict China’s stance. Based on a self-built corpus of 153 news reports and analyzed via AntConc, the study quantitatively and qualitatively identifies distinct patterns in the use of transitivity processes across the two corpora. The research reveals that Chinese media highlight the outlook for future peace-building initiatives, portraying China as a country …

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Distributed Leadership, Innovation, And Organizational Performance In Private Higher Education: A Multilevel Analysis, Ali Mujahidin, Indrianawati Usman, Yetti Dwi Lestari Jun 2026

Distributed Leadership, Innovation, And Organizational Performance In Private Higher Education: A Multilevel Analysis, Ali Mujahidin, Indrianawati Usman, Yetti Dwi Lestari

Asia-Pacific Social Science Review

This research intends to analyze the relationships among distributed leadership, innovation, and organizational performance through knowledge management practices. A quantitative approach with an explanatory design was employed in this research. Data was collected through surveys involving middle management and faculty members in educational studies programs at private universities. Using the Multilevel Structural Equation Model (MSEM), data analysis was conducted with distributed leadership variables as individual variables and knowledge management practices, exploratory innovation, exploitation innovation, and organizational performance as team variables. This study involved 71 education study programs in 30 universities, with 71 heads of study programs and 158 lecturers, so …

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A Case Study Of Sport And Racism In Australia: A Qualitative Document Analysis, Vegneskumar Maniam, Kristy O’Neill Jun 2026

A Case Study Of Sport And Racism In Australia: A Qualitative Document Analysis, Vegneskumar Maniam, Kristy O’Neill

Asia-Pacific Social Science Review

Australia is well known as a ‘sporting nation’ with outstanding elite sporting achievements and grassroots-level sports participation. The reality for Australia’s First Nations people and those from Culturally and Linguistically Diverse (CALD) backgrounds, however, tends to differ from the mainstream Australian population. One of the contributing factors being argued within this paper is the prevalence of historical and contemporary racism in Australian sport. This study focuses on four of Australia’s most popular community-participation sports, including Australian Rules Football (ARF), Cricket, Netball, and Swimming. Using a Qualitative Document Analysis method, this research investigates both primary and secondary sources for instances of …

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Context-Specific Legitimacy In English Language Teaching: Rethinking Nativeness In The Korean Efl Context, Kenn Arcenal, Teri An Joy G. Magpale Jun 2026

Context-Specific Legitimacy In English Language Teaching: Rethinking Nativeness In The Korean Efl Context, Kenn Arcenal, Teri An Joy G. Magpale

Journal of English and Applied Linguistics

Although non-native English-speaking teachers now make up the majority of the global ELT workforce, perceived nativeness continues to function as an enduring filter in hiring and evaluation. This perspective paper examines how that filter operates unevenly across the institutional sectors of South Korea’s EFL labor market, arguing that Filipino English Teachers (FETs) face a distributive rather than a uniformly ideological inequity, with the biggest disadvantage concentrated in commercially driven private academies. Drawing on two companion studies of FETs working across Korean academic sectors (Magpale & Arcenal, 2025, in press) and integrating more recent scholarship on native-speakerism with comparative evidence from …

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Visual Narratives Of Singapore-Johor Relations Through The 1961 And 1962 Water Agreement, Mohd Firdaus Abdullah, Arba’Iyah Mohd Noor, Ismail Ali, Azian Tahir, Meri Anad Jun 2026

Visual Narratives Of Singapore-Johor Relations Through The 1961 And 1962 Water Agreement, Mohd Firdaus Abdullah, Arba’Iyah Mohd Noor, Ismail Ali, Azian Tahir, Meri Anad

Asia-Pacific Social Science Review

The issue of the Water Agreement between Johor and Singapore has been widely focused among scholars, both in the country and abroad. Various approaches have been used to analyze this issue, including historical perspectives, politics, international affairs, news, academic articles, government policies, and other documentation sources. However, the visual dimension that plays an important role in analyzing power tensions and diplomatic relations related to the 1961 and 1962 Water Treaty is often neglected, even though it has great potential to provide a deeper perspective on this issue. This research focuses on three main videos, namely Singapore lays pipes to draw …

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Full Issue (Volume 5, Issue 1): Critical Discourses, Pedagogical Innovations, And Sociocultural Perspectives In Applied Linguistics Jun 2026

Full Issue (Volume 5, Issue 1): Critical Discourses, Pedagogical Innovations, And Sociocultural Perspectives In Applied Linguistics

Journal of English and Applied Linguistics

Abstract not applicable.

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Creative Constructions In Asian And World Englishes - And What They Teach Us, Edgar W. Schneider Jun 2026

Creative Constructions In Asian And World Englishes - And What They Teach Us, Edgar W. Schneider

Journal of English and Applied Linguistics

"Creative constructions" are defined as patterns which deviate slightly but noticeably from grammatical, fully licensed structures in English (and are therefore sometimes branded as "wrong"), inviting specific cognitive associations to make sense of them. It is argued that such structures offer a window into the nature of the cognitive manipulation of linguistic innovations and change. The concept is related to creativity in literature and lingua franca English, and it is surveyed theoretically by asking how established grammatical theories (like traditional grammar, structuralism or generativism) or more recent approaches to the nature of grammar (usage-based linguistics, construction grammar, and complex systems …

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Crispr/Cas9-Based Genome Editing: Understanding Differences In Dna Repair Pathways, Profiles, And Outcomes, Samuel Effah, Shirley Barrera, Nahia Urturi Ortiz, Will Dampier, Michael Nonnemacher, Brian Wigdahl Jun 2026

Crispr/Cas9-Based Genome Editing: Understanding Differences In Dna Repair Pathways, Profiles, And Outcomes, Samuel Effah, Shirley Barrera, Nahia Urturi Ortiz, Will Dampier, Michael Nonnemacher, Brian Wigdahl

Kimmel Cancer Center Faculty Papers

Over a decade of advances in Clustered Regularly Interspersed Short Palindromic Repeats (CRISPR) and CRISPR-associated protein 9 (Cas9)-based technologies have culminated in the first-ever FDA-approved CRISPR/Cas-based therapy. Aside from this approved therapy for sickle cell anemia, several CRISPR/Cas-based therapies are currently under development or testing for a range of chronic diseases, including viral diseases like human immunodeficiency virus type 1 (HIV-1) infection, genetic diseases like familial hypercholesterolemia, and cancer. The success of these therapies hinges on the effective delivery of CRISPR/Cas9 components to target regions, efficient Cas endonuclease editing, repair profiles generated, and their resulting outcomes. Here, we discuss the …

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A Mathematical Model For Managing Diphtheria Outbreaks In Nigeria Via Vaccination, Enhanced Surveillance, Effective Quarantine, And Social Distancing Measures, Hycienth Ortser Orapine, Nyiutya Cephas Ine, Dekera Jacob Washachi, Ali Audu Baidu, Lubem Matthew Kwaghkor Jun 2026

A Mathematical Model For Managing Diphtheria Outbreaks In Nigeria Via Vaccination, Enhanced Surveillance, Effective Quarantine, And Social Distancing Measures, Hycienth Ortser Orapine, Nyiutya Cephas Ine, Dekera Jacob Washachi, Ali Audu Baidu, Lubem Matthew Kwaghkor

Mathematical Modelling and Numerical Simulation with Applications

Diphtheria is a highly infectious respiratory and skin disease that poses a significant threat to global public health. In Nigeria, children and adults with low immunity remain at high risk due to recurring annual outbreaks in the last decade, with a death rate of as high as 68.8\%. This paper presents a deterministic compartmental model to evaluate the effectiveness of interventions implemented by the Nigerian government. The model's mathematical and epidemiological validity is established through proofs of non-negativity and boundedness. The basic reproduction number ($R_0$) is derived, and stability analysis confirms that the diphtheria-free equilibrium is locally and globally asymptotically …

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Can Climate Risk Disclosure Improve The Carbon Performance Of High-Carbon Enterprises? Empirical Evidence From China, An Zeng Jun 2026

Can Climate Risk Disclosure Improve The Carbon Performance Of High-Carbon Enterprises? Empirical Evidence From China, An Zeng

Double Helix Methodology

With growing global concern over climate risk, high-carbon enterprises are assuming an increasingly critical role in strengthening climate resilience and fostering low-carbon development. However, how climate risk disclosure shapes their carbon performance—specifically through what mechanisms and pathways—remains a pivotal yet underexplored question. To address this gap, this study constructs a panel dataset comprising Chinese listed high-carbon companies over the period 2006–2022 and employs a two-way fixed-effects econometric model to assess how climate risk disclosure affects carbon performance while investigating the underlying mediating channel. The empirical results provide robust evidence that enhanced climate risk disclosure improves the carbon performance of high-carbon …

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Enhancement Of Gas Turbine Efficiency By Using Recuperator And Intercooler Systems, Mohammed Saad Kamil Jun 2026

Enhancement Of Gas Turbine Efficiency By Using Recuperator And Intercooler Systems, Mohammed Saad Kamil

Al-Esraa University College Journal for Engineering Sciences

High power density and operational flexibility make gas turbines an indispensable part of contemporary energy conversion systems. However, in the simple cycle configuration, the thermal efficiency is generally low because the exhaust heat loss is large and the compression work is high. The current investigation is focused on enhancing the thermal efficiency of a gas turbine by the introduction of two augmentation schemes, namely a recuperator and an intercooler. A numerical and thermal simulation study was carried out to model the gas turbine cycle based on the first and second laws of thermodynamics. Simplicity and Modified cycles Performance of simple …

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Spatial Estimation For Gas Flaring And Natural Gas Waste From Oil Production Using Remote Sensing And Gis Techniques, Hisham M. Jawad Al Sharaa Jun 2026

Spatial Estimation For Gas Flaring And Natural Gas Waste From Oil Production Using Remote Sensing And Gis Techniques, Hisham M. Jawad Al Sharaa

Al-Esraa University College Journal for Engineering Sciences

This study aims to provide a comprehensive geospatial gas flaring intensity and emission doses analysis throughout oil production areas in Iraq based on remote sensing and GIS-based interpolation methods. Satellite image and spatial data were combined to create a map of flaring locations, refinery locations, and associated CO2-equivalent emissions. The results show that there is a clear spatial variation in the intensity of the emissions ranging from northern regions towards the oil fields in the south near Basra, Rumaila and West Qurna, where refinery density and high flaring activities are observed. Interpolation modelling suggests that the majority of …

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Ai-Enhanced Heat Transfer Optimization In Magnetic Bio-Nanofluids, Hasan Attyah Shaboot Jun 2026

Ai-Enhanced Heat Transfer Optimization In Magnetic Bio-Nanofluids, Hasan Attyah Shaboot

Al-Esraa University College Journal for Engineering Sciences

This study presents a hybrid Artificial Intelligence–Computational Fluid Dynamics (AI-CFD) framework for optimizing heat transfer in magnetic bio-nanofluids subjected to external magnetic fields. Magnetic bio-nanofluids, composed of biocompatible base fluids containing superparamagnetic nanoparticles, exhibit tunable thermal and flow behavior, making them promising for biomedical and micro-cooling applications. Conventional optimization methods based on experiments or brute-force CFD are computationally expensive and limited in exploring the full design space. To overcome these challenges, an Artificial Neural Network (ANN) surrogate model was developed to predict two key performance indicators, the Nusselt number and the friction factor, with high accuracy (R2 > 0.997). The …

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Quality Of Life Indicators In Historic Urban Spaces: A Case Study Of Al-Mustansiriya Madrasa, Baghdad / Iraq, Israa H. Karam Ali, Shireen I. Khazaal Jun 2026

Quality Of Life Indicators In Historic Urban Spaces: A Case Study Of Al-Mustansiriya Madrasa, Baghdad / Iraq, Israa H. Karam Ali, Shireen I. Khazaal

Al-Esraa University College Journal for Engineering Sciences

Historic urban spaces play a central role in shaping social interaction, environmental comfort, and collective identity in cities with deep cultural heritage. Despite this importance, empirical assessments of their performance in terms of Quality of Life (QoL) from the perspective of contemporary users remain limited, particularly in the context of Baghdad. This study examines Quality of Life indicators within a historic urban space through a case study of Al-Mustansiriya Madrasa, one of Baghdad's most prominent historic educational complexes. A descriptive–analytical approach was adopted, integrating a structured questionnaire survey, systematic on-site observation, and spatial analysis based on Space Syntax techniques. The …

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The Pivotal Role Of Artificial Intelligence In Optimizing Pharmaceutical Formulation And Delivery, Ali Khidher Abbas, Mustafa M. Noori, Ibtihal Abdulkadhim Dakhil, Mohammed Hussain Al-Mayahy Jun 2026

The Pivotal Role Of Artificial Intelligence In Optimizing Pharmaceutical Formulation And Delivery, Ali Khidher Abbas, Mustafa M. Noori, Ibtihal Abdulkadhim Dakhil, Mohammed Hussain Al-Mayahy

Al-Esraa University College Journal for Medical Sciences

Artificial intelligence (AI) has emerged as a transformative technological paradigm within the pharmaceutical sciences, offering innovative and forward-looking solutions to surmount the inherent limitations associated with conventional drug development, formulation design, and therapeutic delivery systems. Traditional pharmaceutical methodologies frequently entail protracted development timelines, extensive experimental procedures, and substantial financial expenditures, particularly within the domains of formulation optimization and drug delivery design. The integration of AI-driven technologies – encompassing machine learning (ML), deep learning (DL), artificial neural networks (ANNs), and predictive analytics – has considerably accelerated pharmaceutical research by refining decision-making processes, alleviating experimental burden, and enhancing formulation efficiency. The present …

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Clinical Significance Of Liver Enzyme Biomarkers In Chronic Statin Users, Muayad Khaleel Ibrahim, Saad Mahmoud Saeed Jun 2026

Clinical Significance Of Liver Enzyme Biomarkers In Chronic Statin Users, Muayad Khaleel Ibrahim, Saad Mahmoud Saeed

Al-Esraa University College Journal for Medical Sciences

It is possible that statins, by their dual capacity to modulate (both stimulate and suppress) immune responses, could play a role in influencing the course of autoimmune diseases. Consequently, our investigation was designed to explore how statins impact both the innate and adaptive branches of the immune system, as well as their effect on the crucial mechanism of self-tolerance. This was achieved through the comprehensive measurement of various antibody profiles, specifically including the detection and quantification of autoantibodies, such as antinuclear antibodies and Creatinine kinase, Aldolase, HMGCR antibody, Albumin and Bilirubin and Alanine transaminase, Aspartate aminotransferase, Our investigation employed a …

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Optimization Of Bearing Design In Centrifugal Pumps Using Finite Element And Experimental Methods: Application At South Refineries Company, Basra, Mohammed Hasab Naser Al-Mtasher Jun 2026

Optimization Of Bearing Design In Centrifugal Pumps Using Finite Element And Experimental Methods: Application At South Refineries Company, Basra, Mohammed Hasab Naser Al-Mtasher

Al-Esraa University College Journal for Engineering Sciences

In the study, nonlinear vibration and thermo-mechanical characteristics of centrifugal pump bearings utilized in the cooling tower system of South Refineries Company (Basra) were properly examined using a combined experimental and numerical method. The intent of the study was to learn the impact of misalignment, the nature of the lubrication film, and thermal gradients on the stability of the operation of these bearings and their service life under realistic industry environment conditions. Finite element model (FEM) was constructed and tested on the basis of real field data obtained at the working pumps that allowed realistic distribution of stress and temperature. …

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