Digital Commons Network^™

Plasma Proteome Correlations With Liver Stiffness In Pediatric Cholestasis Implicate Epithelial To Mesenchymal Transition, Benjamin L Shneider, Rupa S Kanchi, Sandra L Grimm, Sridevi Devaraj, Juliet Emamaullee, Jeremy Schraw, Philip J Lupo, Jorge A Bezerra, Kathleen M Loomes, John C Magee, Ronald J Sokol, Kasper S Wang, Alyssa Kriegmeier, Evelyn Hsu, Jean P Molleston, Philip Rosenthal, Rohit Kohli, Saul J Karpen, Simon P Horslen, M Kyle Jensen, Arianna Barbetta, Cristian Coarfa

Faculty, Staff and Students Publications

Background: Pediatric cholestatic liver diseases can be characterized by rapidly progressive fibrosis. A multicenter cross-sectional analysis of vibration-controlled elastography in biliary atresia (BA), alpha-1 antitrypsin deficiency (A1AT), and Alagille syndrome (ALGS) was leveraged to interrogate the plasma proteome relative to liver stiffness measurements (LSM).

Methods: Slow off-rate modified aptamer scanning profiling of >7000 proteins in plasma from 187 children with BA (n=93), A1AT (n=31), ALGS (n=46), and healthy pediatric controls (n=17) was performed, and correlations with LSM were undertaken.

Results: There was an abundance of LSM correlated proteins (BA n=2720, A1AT n=694, ALGS n=5968). Interestingly, a distinct plasma proteome was …

Improving The Accessibility Of Speech For Deaf And Hard-Of-Hearing Individuals Through Affective Captions, Caluã De Lacerda Pataca

Theses

Captions have traditionally served as a bridge between the spoken word and its written representation, helping make speech accessible to Deaf and Hard-of-Hearing (DHH) individuals. It is worth considering, however, how much from speech is left out by this ’bridging’ between sound and visuals. This dissertation describes a research project that has, over six studies, looked at this very issue. We first examined whether there is an issue here at all. What does the experience of DHH individuals with captioning systems tell us about these systems’ shortcomings? For one, we found, captions are felt as monotonous and ambiguous. While communication …

Transcript Diversity In Aging: Cryptic Transcription And Splicing, Brenna S Mccauley, Nicholas Nikoloutsos, Weiwei Dang

Faculty, Staff and Students Publications

Increased transcript diversity, which is caused in part by alternative splicing and cryptic transcription, is an underappreciated aspect of age-associated transcriptome remodeling. Recent work has revealed that structurally novel transcripts increase during aging in many tissues. Genes with cryptic and alternatively spliced transcripts with age are enriched for functional categories relevant to tissue function and aging, and have been implicated in cognitive decline, decreased muscle strength, reduced oocyte quality, immune aging, altered stem cell properties, and senescence. Indeed, there is emerging evidence that alternatively spliced transcripts and elevated cryptic transcription directly contribute to aging phenotypes in multiple tissues. The full …

Predicting Major Depression Among Diverse Online Gamers: The Role Of Internet Addiction And Spirituality, Lindsay Lundeen, John R. Mccall

Counseling, Leadership, and Research Methods Faculty Publications and Presentations

This study analyzed whether religious or spiritual affiliation and therapy enrollment protect against symptoms meeting Major Depressive Disorder criteria beyond demographic, Internet addiction, and described therapy enrollment. Findings illustrated one risk factor and one protective factor associated with experiencing symptoms that meet Major Depressive Disorder criteria: impairments and dysfunctional self-regulation increased participant probability and risk, while religious or spiritual affiliation decreased the probability of and protected participants from depressive symptoms. The findings underscore the complexities of Internet addiction and depression symptoms among a population of diverse online gamers, highlighting a critical need for tailored counseling interventions.

Improving Regulatory Notice, Joshua Ulan Galperin, E. Donald Elliott

Elisabeth Haub School of Law Faculty Publications

Effective notice of law is the cornerstone of any legal system, and yet many federal administrative agencies do not give small businesses, NGOs, and interested citizens notice of the vast amount of new or modified law they produce. They merely publish the text in the Federal Register, which works tolerably well for larger enterprises but not their smaller competitors and citizens' groups. Despite these facts, few scholars have explored how agencies provide notice of the law. Even fewer have proposed ways that agencies could improve the methods they use for giving more effective notice of significant regulatory changes and thereby …

Noise Law, Joshua Ulan Galperin

Elisabeth Haub School of Law Faculty Publications

The rumble of traffic, the drone of air conditioners, the blast of construction equipment. These are the mundane sources of noise pollution that we all experience but rarely think about. Or, if we do think about noise pollution, we don't think of it as a central piece of federal environmental law. This Article, however, demonstrates that noise law is, or was, central to American environmental law, and it offers insights into how environmental protection and administrative governance work today.

In the 1970s, during the height of environmental activism and policymaking, lawmakers recognized noise as a serious pollutant alongside issues we …

The Uniform Commercial Code Survey: Introduction, Jennifer S. Martin, Colin P. Marks, Wayne Barnes

Faculty Scholarship

The survey that follows highlights the most important developments of 2024 dealing with domestic and international sales of goods, personal property leases, payments, letters of credit, documents of title, investment securities, and secured transactions. Along with the usual descriptions of interesting judicial decisions highlighted in the survey, there has also been legislative progress. The 2022 Amendments to the Uniform Commercial Code ("U.C.C.") (the "2022 Amendments")' have been adopted in thirty-one states plus the District of Colombia and introduced in six states.

Drive-By Mediation And Other Opportunistic Distortions Of Process, Nancy A. Welsh

Faculty Scholarship

Many states in the United States, along with many nations, have implemented special benefits and privileges to encourage parties’ use of mediation to assist their communication, negotiation, and ultimate resolution of disputes. This is despite how loosely mediation is defined. This Article discusses how vague definitions, paired with special benefits and privileges, are incentivizing both the opportunistic distortion of mediation and the use of mediation for improper purposes. In Texas, for example, judges are extraordinarily limited in their ability to disapprove parents’ mediated child custody agreements—even if there is reason to worry that an agreement is contrary to the best …

The Gamification Of Banking, Colleen Baker, Christopher K. Odinet

Faculty Scholarship

Gamification is coming to banking. This phenomenon is already gain-ing ground in advertising, healthcare, manufacturing, and, more recently, with the GameStop and AMC meme stock saga in securities trading. The idea behind gamification is to make transactions seem fun, playful, and even casino-like in order to elicit habit-forming, addictive-like effects with consumers. This Article argues that the rise of financial technology (“fintech”) firms and their ever-growing business relationships with incumbent financial institutions has created the necessary conditions for gamification to take hold in the banking sector. In order to explore this observation, we undertake a study of current examples of …

Judicial Enforcement Of Evidence Law, G. Alexander Nunn

Faculty Scholarship

The truth matters. At least it should. In the courtroom, truth can serve as the cornerstone of justice, liberating the innocent, vindicating victims, and holding the guilty to account. Indeed, truth is such a normative imperative that an entire legal discipline now focuses on fostering its discovery at trial—evidence law. By regulating both the reliability of proof and the rationality of cognitive inferences, evidence law seeks to help factfinders discern truth and reach an accurate verdict. And given the importance of that role, one might naturally assume that the strict enforcement of evidence law would be a legal mandate of …

The Sec Proposed Cybersecurity Infrastructure Rules And New Disclosure Requirements, Neal F. Newman, Lawrence J. Trautman, Brian Elzweig

Faculty Scholarship

In addition to regulation of securities market issuers, the Securities & Exchange Commission (SEC) is also responsible for regulation of those entities that provide the networks, either electronic or physical, that enable the functioning of our securities markets. On February 9, 2022, the Commission published a Release for Cybersecurity Risk Management for Investment Advisers, Registered Investment Companies, and Business Development Companies containing proposals that, if adopted, would establish a new cybersecurity incident reporting and disclosure regime and require registered investment advisers (“advisers”) and investment companies (“funds”) to implement policies and procedures designed to address cyber risks. The comment period for …

Serious Games And Complex Thinking: A Study On Gender Differences And Study Discipline In University Students, María Soledad Ramírez‑Montoya, Carolina Alcantar-Nieblas, Leonardo David Glasserman-Morales

Artículos científicos

Serious games are a fundamental tool to promote learning in a playful way and to develop a wide range of cognitive skills such as complex thinking. In this study we sought to first analyze the perceived achievement of complex thinking sub-competencies by majors, and we also aimed to investigate mean differences in the group of students coming from computer science and engineering related majors and by gender of the participants in complex thinking subcompetencies. 417 learners were part of this study, of which 65.7% were male and 34.3% were female. It was found that medical students perceived higher achievement in …

Environmental Bankers: States Are Billing Fossil Fuel Companies For Extreme Weather Disasters, Kelly A. Adam

William & Mary Environmental Law and Policy Review

For decades, common law has been the pathway to remediation for environmental tragedies. Victims of traditional environmental harms can pursue justice through legal challenges like nuisance, negligence, and violations of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). However, climate change–induced natural disasters have led to the normalization of the “Act of God” exception; a policy provision commonly used in insurance law that excludes coverage for damage caused by unforeseeable natural disasters. Even so, real cities suffer the consequences of the real harm, whether insurance accepts it or not; so, who bears the burden of funding the recovery?

Maryland, …

The Lone Dissent, Grant Christensen, Anne Mullins

Washington and Lee Law Review

What can be learned when a Supreme Court Justice decides to write a lone dissent? There exists a powerful set of incentives for Supreme Court opinions to achieve consensus. Although closely divided cases grab news headlines, unanimous opinions are actually the most commonly issued judicial alignment, and cases in which a single Justice dissents are the most unlikely. Despite voluminous academic discussion of judicial behavior, no legal scholarship has focused on the lone dissent. This Article is designed to insert consideration of lone dissenting opinions into the broader discussion of judicial behavior.

Looking at the set of Supreme Court opinions …

Look What You Made Me Do, Russell M. Gold

Washington and Lee Law Review

We have understood for centuries that crime is both the product of social forces and individual choice. We know now that crime is affected by economic deprivation, addiction, trauma, and mental health issues. But American criminal legal processes hide this reality by coercing defendants into expressing a profoundly simple narrative: crime is solely individual choice to do wrong. This coerced narrative finds defendants during a plea colloquy standing up in court saying that they are pleading guilty because they are guilty and for no other reason. A defendant who goes off-script to tell the judge that they have been repeatedly …

Double Dosing: How Brand-Name Pharmaceutical Manufacturers Manipulate Patent Rules To Extend Market Exclusivity, Elizabeth Hertzberg

Washington and Lee Law Review

A robust patent system is important for spurring innovation, but it is not without risk. Because a patent owner has exclusivity over the patented subject matter for a specific term, there is incentive to extend that monopoly however possible. Identical subject matter is unpatentable, but obvious variants of an existing patent may be allowed if the applicant agrees to the same expiration date for both patents. This agreement is called a terminal disclaimer. While patents tied together with terminal disclaimers may not necessarily lead to unjust patent term extensions, an army of terminal disclaimers directed at one invention presents a …

The College Voice, Vol. 62, No. 7 [October 1, 2025], Connecticut College

2025-2026

No abstract provided.

From Disruption To Renewal: Harnessing Divine Interruptions And Strategic Leadership For Transforming Church Culture, Ryan Johnson

Great Commission Research Journal

Church revitalization is a field that addresses refreshing the church’s mission and vision by leaders who assess internal and external factors affecting the congregation’s current state. However, researchers in organizational culture argue that refreshed strategies will be ineffective without also addressing underlying cultural issues. This essay addresses the need for and the process of transforming church culture during the revitalization process. Pastors and leaders bring about cultural change by disrupting the status quo. This disruptive leadership is achieved through two approaches. First, leaders proactively and incrementally disrupt the status quo to influence cultural change through faithful pastoral practices. Secondly, leaders …

A Brief History Of The American Society For Church Growth And Great Commission Research Network, Gary Mcintosh

Great Commission Research Journal

This article surveys the 40‑year history of the Great Commission Research Network, originally founded in 1985 as the American Society for Church Growth. It traces the Society’s origins in the vision of C. Peter Wagner, its early development alongside emerging academic and consulting roles in the Church Growth Movement, and its subsequent evolution through changing leadership, themes, and institutional partnerships. The narrative outlines major milestones, including organizational restructuring, name changes, expanding conference formats, and increasing collaboration with seminaries, denominations, and the Society for Church Consulting. Across four decades, the Society has produced significant research, cultivated key leaders, supported academic scholarship, …

Population Health And Systems Science: Medical Student Feedback On A Novel Approach That Follows A National Curricular Framework, Jeffrey Levin, Gary Beck Dallaghan, Chaynee Atwood, Vanessa Casanova, Cynthia Ball, Theresa Byrd, Emmanuel Elueze, Michael Kennedy, Dalia Nessim, Peter Pendegrass, Yordanos Tiruneh

School of Medicine Faculty Publications and Presentations

Introduction: Population Health and System Science, a longitudinal course at a new medical school in northeast Texas, incorporates case-based learning and experiential field visits during an 18-month pre-clerkship phase. The course integrates content from public and population health, preventive medicine disciplines, and health administration and leadership. Materials and Methods: A cross-sectional survey assessed student self-reports on achievement of session objectives and introduction to national core curricular, cross-cutting, and systems thinking domains. Results: Of 36 students, 33 responded. Most rated objectives favorably. Open-ended responses highlighted relevance to future practice and requested more content on biostatistics, epidemiology, health equity, and healthcare economics, …

(Si15-010) On Perturbations Of Gabor Frames, Jamkhongam Touthang

Applications and Applied Mathematics: An International Journal (AAM)

Stability plays a crucial role in frame theory and its applications. The present paper studies the interaction between Gabor frames and perturbations, presenting perturbation results related to small changes of the frame parameters and the window functions both in regular and irregular settings. Examples are provided for illustration. Additionally, the paper briefly discusses algorithms pertinent to Gabor frames under perturbations and highlights challenging areas in the field.

The Walking Moai Hypothesis: Archaeological Evidence, Experimental Validation, And Response To Critics, Carl P. Lipo, Terry L. Hunt

Anthropology Datasets

The transport of Rapa Nui's (Easter Island) monumental moai statues has been debated for over a century. Based on a systematic analysis of 962 moai, with a focus on 62 road statues, combined with 3D modeling and experimental trials, we demonstrate that these multi-ton megaliths were designed for transport vertically in a controlled "walking" motion facilitated by their carved shapes. Our evidence includes distinctive morphological features of road moai (wide, D-shaped bases and forward lean), archaeological road characteristics (4.5m wide, concave cross-sections), non-random breakage patterns, and successful experimental validation using a precisely-scaled 4.35 metric ton replica based on road …

Une Com Research And Scholarship Fall Forum October 2025, Une Com Research & Scholarship

Osteopathic Student Research Symposia

Program including abstracts from the University of New England College of Osteopathic Medicine’s 2025 Research and Scholarship Fall Forum.

Supplemental content: List of award winners.

Population Genomics And Status Of The Flattened Musk Turtle (Sternotherus Depressus) In The Locust Fork Of The Black Warrior River, Seamus C. O'Brien

Theses

Alabama is home to some of the highest freshwater endemism in the world and ranks near the top in numbers of endangered and extinct species. One of these endangered species is the Flattened Musk Turtle (FMT), only found in the Black Warrior River Drainage of Alabama above the Fall Line. The FMT is listed as “Threatened” by the United State Fish and Wildlife Service under the Endangered Species Act and is considered Critically Endangered by the International Union for the Conservation of Nature due to drastic declines in populations since the 1980s. Declines have been attributed to several factors, including …

In The Hull Of The Uss Disregard: An Analysis Of Secretary Of State Cordell Hull’S Execution Of Foreign Policy In East Asia And The Precipitation Of Armed Conflict Between Japan And The United States, Eric B. Hawkins

Theses

The political career of Cordell Hull was motivated primarily by trade policy and the courting of Central America through the negotiation of reciprocal trade treaties that helped stabilize, for the most part, the entire Western Hemisphere. He was an obvious choice for Roosevelt’s cabinet to address economic instability. But why was he chosen for Secretary of State? The Open Door Policy, adopted by many Western nations in East Asia during the early 20th century, was a petri dish primed for the growth of political strife and international conflict. With the warnings from Hull’s predecessor, Henry Stimson, placed on the back …

Independent- October 2025, Leslie Lozada

The Independent (1988-present)

No abstract provided.

Alfred Russel Wallace Notes 38. Alfred Russel Wallace's "Revolt Of Democracy": A Critical Analysis Of Early 20th Century Labor Theory And Its Contemporary Relevance, James Williams, Charles H. Smith Editor

Faculty/Staff Personal Papers

This article examines Alfred Russel Wallace’s political treatise The Revolt of Democracy (1913), analyzing his theoretical framework for addressing labor unrest and economic inequality in early 20th-century Britain. Wallace's work presents a comprehensive critique of competitive capitalism and proposes systematic government intervention to address structural poverty. Through close textual analysis and comparison with contemporary UK labor conditions, this study evaluates the enduring relevance of Wallace's economic theories and policy prescriptions. The analysis reveals significant continuities between early 20th-century and contemporary debates about living wages, government employment standards, and wealth redistribution, while highlighting both the prescience and limitations of Wallace’s analytical …

Student Perceptions Of Standards-Based Grading In High School Biology, Scott Bohlman

Master's Theses & Capstone Projects

Standards-based grading (SBG) redefines the reporting of student achievement by focusing on proficiency in explicitly defined learning standards rather than the accumulation of points. Although SBG has the potential to improve student learning, variation in implementation can create student confusion and hinder effectiveness. This inquiry-based research project investigated student perceptions of SBG in high school biology classrooms at Cedar Falls High School in Iowa to determine whether the system helps students gain the necessary skills and accurately measures their academic ability. The researcher utilized a mixed-methods approach, collecting quantitative data through surveys of 23 high school biology students and qualitative …

Improving Teacher Expectations For Students With Disabilities, Noah Kullmann

Master's Theses & Capstone Projects

Disability labels for students are indicators that are made known to classroom teachers before the beginning of the year and have the possibility to impact what a teacher might expect from a specific student. The purpose of this study was to better understand how disability labels impact the expectations that teachers have for students, and how providing training to teachers by informing them about the characteristics of a disability or research-based practices to use when teaching students with a specific disability impacts their initial expectations. The researcher administered five different surveys to a group of 31 high school and middle …

Can Bilateralism Endure? The 2023-25 Gaza War And The Abraham Accords Framework, Eli Sperling, Elizabeth Trumpfheller

Journal of Strategic Security

The Abraham Accords, signed in 2020, marked a significant shift in Middle Eastern geopolitics by normalizing relations between Israel and several Arab states: the UAE, Bahrain, and Morocco. These agreements emphasized novel types of Arab-Israeli economic partnerships, security cooperation, and public diplomacy, representing a shift from earlier Israeli peace deals with Egypt (1979) and Jordan (1994), which did not see significant growth in the states’ bilateral cooperation and coordination, particularly in non-security areas. And despite the unprecedented October 2023 Hamas attack on Israel and the ensuing Gaza and Lebanon wars, which intensified regional tensions and sparked widespread anti-Israel protests, the …