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University Of San Diego Magazine Fall 2025, Publications Department Oct 2025

University Of San Diego Magazine Fall 2025, Publications Department

University of San Diego Magazine (1992- )

Beauty, Goodness and Truth; Dear Toreros; Around Alcalá Park; At The Edge of It All; Faith In Action; Torero Spotlight; Torero Athletics; Toreros Making Waves; In Memoriam; Leading With Love


What Can Trends In Emergency Department Visits Tell Us About Child Mental Health?, Han Choi, Adriana Corredor-Waldron, Janet Currie, Chris Felton Oct 2025

What Can Trends In Emergency Department Visits Tell Us About Child Mental Health?, Han Choi, Adriana Corredor-Waldron, Janet Currie, Chris Felton

Cowles Foundation Discussion Papers

Increases in mental health diagnoses and suicidal behaviors in Emergency Departments are often cited as evidence of an accelerating child mental health crisis. We ask whether trends in ED visits provide an accurate picture of changes in U.S. child mental health. These measures have been profoundly affected by changing conventions about screening, defining, and coding of mental illness. We conclude that child mental health has been deteriorating, but not by the startling magnitudes suggested by jumps and trends in some measures such as suicidal ideation. Although reported suicidal behaviors rose 228% from 2006–2021, the true rise in mental health disorders …


Concussion Knowledge, Attitudes, And Behaviors: A Comparison Study Of Youth Athletes And Their Parents, Summer D Ott, Sukhnandan K Cheema, Holden Axel, Seema S Aggarwal, Natalie R Parks, Nikhil Gattu, Philip Schatz Oct 2025

Concussion Knowledge, Attitudes, And Behaviors: A Comparison Study Of Youth Athletes And Their Parents, Summer D Ott, Sukhnandan K Cheema, Holden Axel, Seema S Aggarwal, Natalie R Parks, Nikhil Gattu, Philip Schatz

Faculty, Staff and Student Publications

Objective: Given the rising participation in high school athletics and the concerning trend of underreporting concussions, this study aims to identify and compare factors influencing sports-related concussion (SRC) awareness and reporting among youth athletes to their parents.'

Methods: Surveys were completed by 239 student-athletes (ages 13-19) and their parents, using a modified Rosenbaum Concussion Knowledge and Attitudes Survey-Student Version (RoCKAS-ST) and demographic questionnaires. Statistical analyses, including paired sample t-tests, ANOVAs, and Spearman's correlations, compared knowledge and attitudes between groups and examined demographic influences.

Results: Parents showed significantly higher concussion knowledge (CKI: t(230) = 5.18, p < .001) and safer attitudes (CAI: t(230) = 10.62, p < .001) than their children. Knowledge scores varied significantly by race and socioeconomic status, with White parents scoring higher than Hispanic and African American parents (F(3,224) = 8.97, p < .001). Child knowledge scores also differed by race (F(4,223) = 3.73, p = .006) …


Morphometric Analysis Of Spina Bifida After Fetal Repair Shows New Subtypes With Associated Outcomes, L K Mann, S Pandiri, N Agarwal, H Northrup, K S Au, E Grundberg, E P Bergh, M T Austin, R Patel, B Miller, S Zhu, J S Feinberg, D Lai, K Tsao, S A Fletcher, R Papanna Oct 2025

Morphometric Analysis Of Spina Bifida After Fetal Repair Shows New Subtypes With Associated Outcomes, L K Mann, S Pandiri, N Agarwal, H Northrup, K S Au, E Grundberg, E P Bergh, M T Austin, R Patel, B Miller, S Zhu, J S Feinberg, D Lai, K Tsao, S A Fletcher, R Papanna

Faculty, Staff and Student Publications

Objectives: The binary classification of spina bifida lesions as myelomeningocele (with sac) or myeloschisis (without sac) belies a spectrum of morphologies. This study aimed to characterize types of spina bifida lesion and correlate them with preoperative presentation and postoperative outcome.

Methods: This was a secondary analysis of a prospective cohort of patients referred for fetal spina bifida who underwent fetoscopic repair between 2020 and 2023 at a single center. We evaluated lesion morphology on high-resolution intraoperative images and videos to categorize lesions based on placode exposure and nerve root stretching. The reproducibility of lesion classification was assessed using the Kappa …


​​​Creating A Resident And Fellow Scholarly Activity Tracking Tool In A Large Academic Health System: A Dissertation In Practice​, Elyse Anne Wieszczecinski Oct 2025

​​​Creating A Resident And Fellow Scholarly Activity Tracking Tool In A Large Academic Health System: A Dissertation In Practice​, Elyse Anne Wieszczecinski

Theses and Dissertations

Documenting and reviewing resident and fellow scholarly activity within a sponsoring institution can be a laborious task. With multiple lines of information coming from a wide variety of sources, this problem of practice implemented the Information Systems Success Model to help develop a database by which this information can be collected in a way that is efficient while maintaining the need for a user-friendly product. While other healthcare entities have also incorporated this model into their scholarly activity collection, these are still individual needs of the sponsoring institution and its constituents to consider when adapting the strategy. Using an improvement …


Coefficients Of The Characteristic Polynomial Of A Hypergraph And Their Combinatorial Properties, Utku Okur Oct 2025

Coefficients Of The Characteristic Polynomial Of A Hypergraph And Their Combinatorial Properties, Utku Okur

Theses and Dissertations

We investigate the combinatorial properties of the characteristic polynomial $\phi_\mathcal{H}\ev{t}$ of a hypergraph $\mathcal{H}$, in particular, its coefficients. Due to a classical result of Jacobi, the generating function of closed walks at a vertex $u$ in a graph $G$ is determined by the rational function $\phi_{G-u}(t) / \phi_G(t)$. The connection between closed walks of $G$ and its characteristic polynomial has a known elegant proof via an application of Viennot's Heaps of Pieces framework, where cycles are taken as pieces and the concurrence relation is sharing a vertex. Here, we prove a bijection between heaps with a unique maximal piece containing …


Ai-Driven Autonomous Manufacturing: A Novel Taxonomy, Vision-Guided Planning, And Diversity-Aware Active Learning Frameworks, Ibrahim Yousif Oct 2025

Ai-Driven Autonomous Manufacturing: A Novel Taxonomy, Vision-Guided Planning, And Diversity-Aware Active Learning Frameworks, Ibrahim Yousif

Theses and Dissertations

Manufacturers face two opposing challenges: the escalating demand for customized products and the pressure to reduce lead times. Current manufacturing equipment, although reliable, operates at the limits of its technology and lacks adaptability to dynamic environments. This trade-off has been described as the optimal degree of automation, a threshold beyond which further automation incurs more cost than benefit. Smart manufacturing has introduced adaptive, data-driven systems, but many deployments still lack the contextual adaptability and autonomous decision-making required to handle unplanned disruptions. This underscores the need for intelligent, autonomous systems capable of real-time adaptation without costly reconfiguration, minimizing human intervention during …


Hearing The Difference: Just Intonation Techniques Utilizing Distortion Product Otoacoustic Emissions In Viola Performance, Calj Green Umezono Oct 2025

Hearing The Difference: Just Intonation Techniques Utilizing Distortion Product Otoacoustic Emissions In Viola Performance, Calj Green Umezono

Theses and Dissertations

Difference tones, also known as distortion product otoacoustic emissions, are the result of active phenomena in the human cochlea during the conversion of sound waves into bioelectrical signals. Difference tones make it possible to explore alternative musical tuning systems beyond the twelve-tone, equally tempered regime. Musicians have investigated difference tones since the 18th Century in Euro-American musical contexts, but their application has so far been limited in scope. Advances in science, technology, and music theory from the late 19th Century through the early 21st Century have given present-day violists the opportunity to more fully understand the virtues of difference tones …


Machine-Learning-Assisted Discovery Of Lattice Dynamics Signatures Of Sodium Superionic Conductors, Ogheneyoma Maxwell Aghoghovbia Oct 2025

Machine-Learning-Assisted Discovery Of Lattice Dynamics Signatures Of Sodium Superionic Conductors, Ogheneyoma Maxwell Aghoghovbia

Theses and Dissertations

Sodium superionic conductors are key to the development of all-solid-state sodium batteries. Discovery of new superionic conductors has traditionally relied on insights from material defect chemistry and the transition/hopping theory, while the role of lattice vibrations, i.e., phonons, remains underexplored. We identify key lattice dynamics signatures that govern ionic conductivity by analyzing the phonon mean squared displacement (MSD) of Na+ ions. By high-throughput screening of a dataset of 3903 Na-containing structures, we establish a strong positive correlation between phonon MSD and diffusion coefficients, providing a quantitative correlation between lattice dynamics and ion transport. To accelerate this discovery, we incorporate …


From Seapower To Shining Seapower, Michael Lee Oct 2025

From Seapower To Shining Seapower, Michael Lee

Publications and Research

The liberal world order is dead: the United States has abandoned both the domestic and international institutional commitments that enabled it to function. How can liberal democracy survive in an increasingly hostile world? How can liberal democracies grow powerful enough to defend themselves without becoming the empires they fear? I argue that seapowers have historically represented a distinct kind of hegemon, that is more amenable to international cooperation, and democracy at home. Moreover, the transition from declining seapowers to rising ones has played a vital role in preserving a space for more liberal states (relative to their historical context), such …


Contracting Around Treaties, Aaron Simowitz Oct 2025

Contracting Around Treaties, Aaron Simowitz

Vanderbilt Journal of Transnational Law

No abstract provided.


Self-Defense Without Overreach: How Status Of Forces Agreements Address The Legal Gaps In Article 51, Alexis Shaw Oct 2025

Self-Defense Without Overreach: How Status Of Forces Agreements Address The Legal Gaps In Article 51, Alexis Shaw

Vanderbilt Journal of Transnational Law

No abstract provided.


Killing The Wto, Katayoon Beshkardana Oct 2025

Killing The Wto, Katayoon Beshkardana

Vanderbilt Journal of Transnational Law

No abstract provided.


Tides And Crossroads: The Gender Era Of The Inter-American Court Of Human Rights, Rosa Celorio Oct 2025

Tides And Crossroads: The Gender Era Of The Inter-American Court Of Human Rights, Rosa Celorio

Vanderbilt Journal of Transnational Law

No abstract provided.


Multiscale Geometric Analysis In Endovascular Therapies: Ex Vivo, In Silico Approaches, Dima Hussein Ali Bani Hani Oct 2025

Multiscale Geometric Analysis In Endovascular Therapies: Ex Vivo, In Silico Approaches, Dima Hussein Ali Bani Hani

Theses and Dissertations

In this work, we address a persistent global challenge of vascular disease, specifically peripheral artery disease (PAD), and arteriovenous fistula (AVF) complications in patients with end-stage kidney disease (ESKD). The important role of vascular geometry in disease intervention plans and the development of endovascular therapeutic strategies (e.g., Drug-coated balloon (DCBs)) is critical in addressing these challenges.

This study evaluates the feasibility of co-delivery of paclitaxel (PTX) and valsartan (VAL) using urea-based coatings in DCB, analyzes the coating morphology and microstructural changes to improve therapeutic results. A computational finite element model was developed to complement experimental work, simulate tissue-coating interactions, compute …


The Church As An Ecological And Cultural Anchor: Examining Its Role In Gifted Education, Advanced Academic Access, And Educational Equity, Matrissa Bennett Oct 2025

The Church As An Ecological And Cultural Anchor: Examining Its Role In Gifted Education, Advanced Academic Access, And Educational Equity, Matrissa Bennett

Theses and Dissertations

This action research study examines the role of the Black church as an ecological and cultural anchor in addressing the inequities of gifted education and expanding access to advanced academic opportunities for Black students. The study is grounded in Bronfenbrenner’s ecological systems theory, critical race theory, and racial and ethnical socialization, and it explores how the Black church can support student development, empower parental advocacy, and partner with schools to promote educational equity. Conducted at Mountain Valley Baptist Church in South Carolina, the interventions included student mentoring, goal setting sessions, academic enrichment, emotional support initiatives, a parent workshop, and a …


A Qualitative Study Exploring Teachers’ Beliefs And Practices Supporting African American Male Readers, Rhonda Douglas Sumter Oct 2025

A Qualitative Study Exploring Teachers’ Beliefs And Practices Supporting African American Male Readers, Rhonda Douglas Sumter

Theses and Dissertations

Despite decades of educational reform, African American male students continue to experience persistent disparities in reading achievement. This qualitative case study explores the beliefs and pedagogical practices of three elementary educators identified as effective in supporting the reading development of African American males. Drawing on the frameworks of Culturally Relevant Pedagogy (Ladson-Billings, 1995) and Critical Race Theory (Delgado & Stefancic, 2012), the study seeks to illuminate how educators affirm students’ identities, maintain rigorous expectations, and create responsive learning environments that foster academic success.

Data sources included in-depth teacher interviews and classroom observations. Thematic analysis revealed three interconnected practices across cases: …


Investigating Connections Among Cognitive Coaching, Student Agency And Achievement In Ninth Grade Algebra 1, Terri Renee Rathburn Oct 2025

Investigating Connections Among Cognitive Coaching, Student Agency And Achievement In Ninth Grade Algebra 1, Terri Renee Rathburn

Theses and Dissertations

This convergent parallel mixed-methods action research study explored the application of Cognitive Coaching as a student-centered intervention to promote agency and academic achievement in a ninth-grade Algebra 1 classroom. Grounded in Bandura’s Social Cognitive Theory and informed by self-regulated learning and agentic engagement frameworks, the study investigated how structured coaching conversations supported students’ intentionality, forethought, self-reactiveness, and self-reflectiveness.

Findings indicate that students who engaged in coaching demonstrated measurable growth in self-reported agency and thematic analysis of coaching transcripts revealed shifts from passive compliance to proactive engagement. While achievement results on the Algebra 1 end of course assessment did not reveal …


The Role Of Language Ideologies In Saudi Elementary English Education: Efl Teacher’S Perspectives And Experiences, Ghanem Saad S Alghuwainem Oct 2025

The Role Of Language Ideologies In Saudi Elementary English Education: Efl Teacher’S Perspectives And Experiences, Ghanem Saad S Alghuwainem

Theses and Dissertations

This dissertation examines how Saudi elementary English teachers understand and enact language ideologies in a period of rapid educational change and national reform. Using a comparative case study of five teachers in Al-Ahsa, the study triangulates semi-structured interviews, classroom audio recordings, and teaching materials to compare stated beliefs with observable practice. The analysis is guided by the theories of English hegemony and language and gender ideology, which together illuminate how global linguistic hierarchies are localized through teachers’ beliefs and practices. Findings reveal that teachers occupy an ideologically complex position as they balance the national push for English proficiency under Vision …


Morphometric Analysis Of Spina Bifida After Fetal Repair Shows New Subtypes With Associated Outcomes., L K Mann, S Pandiri, N Agarwal, H Northrup, K S Au, Elin Grundberg, E P Bergh, M T Austin, R Patel, B Miller, S Zhu, J S Feinberg, D Lai, K Tsao, S A Fletcher, R Papanna Oct 2025

Morphometric Analysis Of Spina Bifida After Fetal Repair Shows New Subtypes With Associated Outcomes., L K Mann, S Pandiri, N Agarwal, H Northrup, K S Au, Elin Grundberg, E P Bergh, M T Austin, R Patel, B Miller, S Zhu, J S Feinberg, D Lai, K Tsao, S A Fletcher, R Papanna

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVES: The binary classification of spina bifida lesions as myelomeningocele (with sac) or myeloschisis (without sac) belies a spectrum of morphologies. This study aimed to characterize types of spina bifida lesion and correlate them with preoperative presentation and postoperative outcome.

METHODS: This was a secondary analysis of a prospective cohort of patients referred for fetal spina bifida who underwent fetoscopic repair between 2020 and 2023 at a single center. We evaluated lesion morphology on high-resolution intraoperative images and videos to categorize lesions based on placode exposure and nerve root stretching. The reproducibility of lesion classification was assessed using the Kappa …


Association Between Weight Stigma Experiences In Healthcare And Self-Reported Healthcare Avoidance In A National Sample., Kathleen M. Robinson, Aaron M. Scherer, Alithea N. Zorn, Michelle A. Mengeling, Helena Laroche Oct 2025

Association Between Weight Stigma Experiences In Healthcare And Self-Reported Healthcare Avoidance In A National Sample., Kathleen M. Robinson, Aaron M. Scherer, Alithea N. Zorn, Michelle A. Mengeling, Helena Laroche

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVES: Although weight stigma in healthcare is common, existing measures may not capture the full range of patients' weight stigma experiences in clinical practice. We aimed to examine how physical examination by healthcare providers, communication, and the built environment perpetuate weight stigma and impact healthcare avoidance. Items from the previously developed Weight Stigma in Healthcare Inventory (WSHCI) were tested to assess weight stigma experiences and assess association with healthcare avoidance.

METHODS: Two sample groups, identified through ResearchMatch and a Qualtrics survey panel, completed the WSHCI online. We analyzed the association between individual items and healthcare avoidance, and between a summation …


Gender Trends In Professional Advancement Among Academic Pediatric Neurologists., Juliet K. Knowles, Angela L. Hewitt, Prathyusha Teeyagura, Bren Botzheim, Derek Boothroyd, Ria Pal, Chrisoula Cheronis, Shermila Pia, Rebecca Macrae, Christine Shrock, Taelor Hancock, Rayann Solidum, Jaclyn Peraino, Amy Hill, Laura Owlett, Sara N. Moss, Catherine Tran, Daniel A. Castillo, Mark S. Wainwright, Renée A. Shellhaas, Nomazulu Dlamini, Mustafa Sahin, Rose N. Gelineau-Morel, Joshua L. Bonkowsky Oct 2025

Gender Trends In Professional Advancement Among Academic Pediatric Neurologists., Juliet K. Knowles, Angela L. Hewitt, Prathyusha Teeyagura, Bren Botzheim, Derek Boothroyd, Ria Pal, Chrisoula Cheronis, Shermila Pia, Rebecca Macrae, Christine Shrock, Taelor Hancock, Rayann Solidum, Jaclyn Peraino, Amy Hill, Laura Owlett, Sara N. Moss, Catherine Tran, Daniel A. Castillo, Mark S. Wainwright, Renée A. Shellhaas, Nomazulu Dlamini, Mustafa Sahin, Rose N. Gelineau-Morel, Joshua L. Bonkowsky

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.


Postcolonial Policies And Practices Towards Language In Algeria And Côte D’Ivoire, Charlotte Anne Dutcher , '26 Oct 2025

Postcolonial Policies And Practices Towards Language In Algeria And Côte D’Ivoire, Charlotte Anne Dutcher , '26

Senior Theses, Projects, and Awards

This thesis discusses language policies and practices in Algeria and Côte d’Ivoire. These two countries were both colonized by France in the 19th century, and under their rule, French was enforced as an official language across French colonies. After their respective decolonizations in the mid-20th century, Algeria and Côte d’Ivoire diverged in their language policies. Côte d’Ivoire kept French as an official language, and Algeria instead chose Arabic, pursuing a national policy of Arabization. This thesis aims to analyze the factors contributing to these differing policies, while also addressing the language practices, and how they vary from the policies. To …


Between Opposite And Unity: A Cross-Linguistic Study Of Contranyms In Classical Chinese, German, And English, Che Lu , '26 Oct 2025

Between Opposite And Unity: A Cross-Linguistic Study Of Contranyms In Classical Chinese, German, And English, Che Lu , '26

Senior Theses, Projects, and Awards

This thesis aims to contribute to the study of contranyms — a special kind of polysemy where one word, character, or even morpheme, has two contradictory meanings — from a comparative perspective by examining representative examples in Classical Chinese, English, and German, with a brief consideration of the absence of such phenomena in Modern Chinese. With the help of Natural Semantic Metalanguage (NSM) and Hegelian dialectics, this study will analyze how such words encode semantic dialectics and the evolution of meaning.

The selection of these three languages reflects their distinct typologies and approaches to meaning formation. Classical Chinese, as an …


Molecular And Genetic Landscapes Of Retina And Brain Microglia In Neurodegenerative Diseases, Khang Ma, Rinki Ratnapriya Oct 2025

Molecular And Genetic Landscapes Of Retina And Brain Microglia In Neurodegenerative Diseases, Khang Ma, Rinki Ratnapriya

Faculty, Staff and Students Publications

Microglia-driven dysregulation has emerged as a significant underlying mechanism in many neurodegenerative diseases, such as age-related macular degeneration (AMD) and Alzheimer's disease (AD). Although both brain and retinal microglia originate from the yolk sac, it is uncertain whether they share molecular similarities or genetic and molecular foundations related to neurodegenerative diseases. In this study, we examine the transcriptomic and epigenetic profiles of retina and brain microglia through integrative analyses of single-nucleus RNA sequencing (snRNA-seq) and single-nucleus ATAC sequencing (snATAC-seq) from 97 independent human samples across 11 different studies. Our findings reveal that retina and brain microglia share similar expression and …


Protein Kinase Rock1 Activates Mitochondrial Fission Linking To Oxidative Stress And Muscle Atrophy, Meijun Si, Jihong Chen, Rizhen Yu, Hongchun Lin, Feng Li, Sungyun Jung, Sandhya S Thomas, Farhard R Danesh, Yanlin Wang, Hui Peng, Zhaoyong Hu Oct 2025

Protein Kinase Rock1 Activates Mitochondrial Fission Linking To Oxidative Stress And Muscle Atrophy, Meijun Si, Jihong Chen, Rizhen Yu, Hongchun Lin, Feng Li, Sungyun Jung, Sandhya S Thomas, Farhard R Danesh, Yanlin Wang, Hui Peng, Zhaoyong Hu

Faculty, Staff and Students Publications

Introduction: Chronic kidney disease (CKD) is associated with protein-energy wasting, characterized by a reduction in muscle mass and strength. Although mitochondrial dysfunction and oxidative stress are implicated in the pathogenesis of muscle wasting, underlying mechanisms remain unclear.

Methods: Here, we used transcriptomic analysis, metabolomics analyses, and mouse gene manipulation to investigate the effects of mitochondrial plasticity and oxidative stress on muscle wasting the subtotal nephrectomy mouse models of CKD. The mice with CKD were age- and sex-matched to sham-operated controls.

Results: Through these approaches, Rho-associated kinase ROCK1 emerged as a key molecule responsible for the observed mitochondrial fission and oxidative …


Private Law Without Precedent, Danielle D’Onfro Oct 2025

Private Law Without Precedent, Danielle D’Onfro

Vanderbilt Law Review

A common-law system assumes that judges regularly issue new opinions that clarify and update the law over time. At the same time, our federal system assumes that state courts will do the bulk of judicial lawmaking, especially in private law. And, with a few exceptions, our broader legal system assumes that state private law has allocated entitlements and obligations into a coherent system. None of these assumptions has been true for a long time. This Article offers a comprehensive account of when and why these assumptions about the proper functioning of private law fail. It then uses this account to …


Plasma Proteome Correlations With Liver Stiffness In Pediatric Cholestasis Implicate Epithelial To Mesenchymal Transition, Benjamin L Shneider, Rupa S Kanchi, Sandra L Grimm, Sridevi Devaraj, Juliet Emamaullee, Jeremy Schraw, Philip J Lupo, Jorge A Bezerra, Kathleen M Loomes, John C Magee, Ronald J Sokol, Kasper S Wang, Alyssa Kriegmeier, Evelyn Hsu, Jean P Molleston, Philip Rosenthal, Rohit Kohli, Saul J Karpen, Simon P Horslen, M Kyle Jensen, Arianna Barbetta, Cristian Coarfa Oct 2025

Plasma Proteome Correlations With Liver Stiffness In Pediatric Cholestasis Implicate Epithelial To Mesenchymal Transition, Benjamin L Shneider, Rupa S Kanchi, Sandra L Grimm, Sridevi Devaraj, Juliet Emamaullee, Jeremy Schraw, Philip J Lupo, Jorge A Bezerra, Kathleen M Loomes, John C Magee, Ronald J Sokol, Kasper S Wang, Alyssa Kriegmeier, Evelyn Hsu, Jean P Molleston, Philip Rosenthal, Rohit Kohli, Saul J Karpen, Simon P Horslen, M Kyle Jensen, Arianna Barbetta, Cristian Coarfa

Faculty, Staff and Students Publications

Background: Pediatric cholestatic liver diseases can be characterized by rapidly progressive fibrosis. A multicenter cross-sectional analysis of vibration-controlled elastography in biliary atresia (BA), alpha-1 antitrypsin deficiency (A1AT), and Alagille syndrome (ALGS) was leveraged to interrogate the plasma proteome relative to liver stiffness measurements (LSM).

Methods: Slow off-rate modified aptamer scanning profiling of >7000 proteins in plasma from 187 children with BA (n=93), A1AT (n=31), ALGS (n=46), and healthy pediatric controls (n=17) was performed, and correlations with LSM were undertaken.

Results: There was an abundance of LSM correlated proteins (BA n=2720, A1AT n=694, ALGS n=5968). Interestingly, a distinct plasma proteome was …


Defining The Field Of Law And Macroeconomics: A Framework From International Monetary Law, Nikita Aggarwal, Adam Feibelman Oct 2025

Defining The Field Of Law And Macroeconomics: A Framework From International Monetary Law, Nikita Aggarwal, Adam Feibelman

Articles

This Article proposes an analytical framework for defining the contours of the emerging field of law and macroeconomics drawing on the International Monetary Fund's principle of "macro-criticality." Such a framework can help steer scholarly debate toward a clearer understanding of the relationship between law and the economy and inform policymaking within that domain. In its native context, the macro-criticality principle limits the IMF's jurisdiction to policy areas that are critical for member countries' domestic and external stability. The IMF's approach distinguishes between a core set of macrocritical policies and other non-core policies that are contextually macrocritical. Over time, the IMF …


Transcript Diversity In Aging: Cryptic Transcription And Splicing, Brenna S Mccauley, Nicholas Nikoloutsos, Weiwei Dang Oct 2025

Transcript Diversity In Aging: Cryptic Transcription And Splicing, Brenna S Mccauley, Nicholas Nikoloutsos, Weiwei Dang

Faculty, Staff and Students Publications

Increased transcript diversity, which is caused in part by alternative splicing and cryptic transcription, is an underappreciated aspect of age-associated transcriptome remodeling. Recent work has revealed that structurally novel transcripts increase during aging in many tissues. Genes with cryptic and alternatively spliced transcripts with age are enriched for functional categories relevant to tissue function and aging, and have been implicated in cognitive decline, decreased muscle strength, reduced oocyte quality, immune aging, altered stem cell properties, and senescence. Indeed, there is emerging evidence that alternatively spliced transcripts and elevated cryptic transcription directly contribute to aging phenotypes in multiple tissues. The full …