Digital Commons Network^™

Associations Of Blood Pressure Level And Variability With Cortical Thickness: A Cross-Sectional Analysis From The Maracaibo Aging Study, Romeo De Leon, Shana Garza, Silvia Mejia-Arango, Kristina Vatcheva, Sokratis Charisis, Claudia L. Satizabal, Luis J. Mena, Joseph H. Lee, Joseph D. Terwilliger, Eron Manusov

School of Medicine Publications

Background: Although high blood pressure (BP) level and variability are associated with Alzheimer's Disease (AD), their relationship with cortical thickness in brain regions that are associated with AD is unclear. Furthermore, the role of 24-hour BP has not been examined. We investigated the associations of office and ambulatory BP measures with cortical thickness in brain regions implicated in AD.

Methods: We performed a cross sectional analysis of 304 participants without dementia from a population-based study with office and 24-hour BP and magnetic resonance imaging (MRI) data. We considered cortical thickness values derived from 10 regions throughout the frontal, parietal, and …

Efficacy And Safety Of Pyrimidine Nucleos(T)Ide Therapy In Thymidine Kinase 2 Deficiency, Michio Hirano, Caterina Garone, Richard Haas, Carmen Paradas, Fernando Scaglia, Irene Rebollo Mesa, Carl Chiang, Anny-Odile Colson, Susan Vanmeter, Cristina Domínguez-González

Faculty, Staff and Students Publications

Thymidine kinase 2 deficiency (TK2d) (MIM 609560) is an ultra-rare, autosomal recessive mitochondrial myopathy caused by TK2 variants, leading to mitochondrial DNA depletion and/or multiple deletions. People with thymidine kinase 2 deficiency experience progressive myopathy, bulbar weakness and respiratory insufficiency, often losing the ability to walk, eat and breathe independently. Doxecitine and doxribtimine represents the first approved treatment for patients with thymidine kinase 2 deficiency with age of symptom onset ≤12 years by the US Food and Drug Administration and the European Medicines Agency; previously, disease management was limited to supportive care. We investigated the efficacy and safety of pyrimidine …

Case Report: Molecular Diagnostics And Clinical Courses Of Two Adult Spinal Pilocytic Astrocytoma Long-Term Survivors With Gtf2i::Braf Fusion, Lorenzo Argao, Pinar E Zerk, Hsiang-Chih Lu, Zied Abdullaev, Martha Quezado, Michelle L Cassidy, Bennett Mclver, Anna Choi, Marissa Panzer, Renee Tweneboah-Koduah, Lily Polskin, Marta Penas-Prado, Paul Park, Nathan Clarke, Kenneth Aldape, Jacob Mandel, Byram H Ozer

Faculty, Staff and Students Publications

Introduction: Pilocytic astrocytomas are driven by BRAF and mitogen-activated protein kinase (MAPK) alterations, typically KIAA1549::BRAF fusions. A rare GTF2I::BRAF fusion has been described, but little is known about these cases.

Case report: Here, we report two cases with GTF2I::BRAF fusions. Case 1 is a 36-year-old man initially diagnosed with myxopapillary ependymoma at the conus medullaris with three recurrences over 23 years requiring two surgeries, three rounds of radiation therapy, and one round of lapatinib/temozolomide. A distant disease focus in T3/T4 was sampled and tested with modern diagnostic techniques revealing a pilocytic astrocytoma on histology and methylation profiling. The patient has …

Reframing Trauma-Informed Care For Refugee And (Im)Migrant Health Systems: From Interpersonal Practice To Structurally Embedded Care, Hyojin Im, Sophia Banu, Aisha Koroma, Sarmaya Mustafayeva

Faculty, Staff and Students Publications

No abstract provided.

Prevalence Of Substance Use In Northwest Syria: A Cross-Sectional Study, Isabel Draper, Dania Albaba, Heba Mesbah, Huda Taktak, Nidhal Saadoun, Mohammad Alhusein, Elharit Alissa, Anas Barbour, Zaher Sahloul, Nidal Moukaddam

Faculty, Staff and Students Publications

Objectives: Syria has undergone significant socio-political turmoil since 2011 as internal conflict displaced portions of the population, destroyed infrastructure, and destabilized the economy. In the context of multilevel healthcare system disruptions, there have been increasing reports of substance use. This study seeks to evaluate patterns of substance use in Northwestern Syria.

Methods: Trained staff administered questionnaires to community members in Azaz, Syria. Questions focused on the substance use prevalence, societal and public health impacts, and perspectives on treatment availability.

Results: 480 individuals were surveyed (80·88% male, 19·12 % female; 43·39% were 18-25 yrs, 11·5% reported personal substance use). H-booz (amphetamines), …

Variability In Documentation Of Neurological And Psychiatric Examinations Among Emergency Department Patients With Behavioral Health-Related Presentations: A Retrospective Study, Heba Mesbah, Payton Kim, Jide Oluwadare, Abdulelah Almanie, Inaara Malick, Nidal Moukaddam

Faculty, Staff and Students Publications

Background: Emergency departments (EDs) serve as a critical safety net for individuals experiencing acute behavioral health crises, a population that faces substantial medical morbidity and well-documented disparities in healthcare delivery. Thorough physical and neuropsychiatric assessment is essential in this setting to identify medical conditions that may mimic or exacerbate psychiatric symptoms. Incomplete documentation of these assessments may reflect gaps in care processes and represent a potential marker of inequity.

Objective: To characterize the completeness of documented neurological and psychiatric examinations among adult ED patients presenting with primary behavioral health-related chief complaints and to assess whether documentation patterns suggest persistent gaps …

Metabolites Produced By Agat+ Cells Support Regeneration In The Planarian Schmidtea Mediterranea, Aubrey M Kent, Carlos Guerrero-Hernández, Carolyn Brewster, Sean Mckinney, Jason A Morrison, Mary C Mckinney, Eric J Ross, Frederick G Mann, Blair W Benham-Pyle, Alejandro Sánchez Alvarado

Faculty, Staff and Students Publications

Planarians exhibit extraordinary regenerative abilities driven by pluripotent neoblasts, yet the roles of post-mitotic progenitor and differentiated cells in this process remain incompletely understood. Here, we investigate the function of agat+ cells, epidermal progenitors expressing members of the arginine:glycine amidinotransferase (agat) gene family, in the regeneration of Schmidtea mediterranea. Comprehensive analysis of all five planarian agat paralogs revealed that agat-1, -2, -3, and -4 are co-expressed in subepidermal populations enriched at wound sites, while agat-5 is minimally expressed. RNAi-mediated knockdown of agat-1 and agat-2 resulted in severe defects: agat-1 primarily disrupted tissue homeostasis, …

Personalizing Therapies Over The Course Of Hormone Receptor-Positive/Her2-Negative Metastatic Breast Cancer, Akshara Singareeka Raghavendra, Senthil Damodaran, Carlos H Barcenas, Suzanne A Fuqua, Rachel M Layman, Debu Tripathy

Faculty, Staff and Students Publications

The hormone receptor (HR)‐positive/human epidermal growth factor receptor 2 (HER2)‐negative breast cancer subtype accounts for most early and metastatic breast cancer (MBC) cases. HR‐positive/HER2‐negative MBC is characterized by a relatively prolonged, although variable, disease course and substantial intertumoral and intratumoral heterogeneity. Although endocrine‐based therapies remain the cornerstone of treatment, nearly all patients eventually develop resistance, which is increasingly addressed with biologically targeted agents and newer‐generation cytotoxic drugs. This review summarizes the current understanding of HR‐positive/HER2‐negative MBC biology, highlighting mechanisms of intrinsic and acquired resistance, including driver genomic alterations that, along with clinical factors, help guide therapeutic choices and sequencing. The …

Dual Targeting Of Amrc12 And Malassezia Globosa Disrupts Myc Liquid Condensates-Driven Nuclear Pore Complex Biogenesis In Neuroblastoma, Anpei Hu, Chunhui Yang, Zhijie Wang, Xiaolin Wang, Xinyue Li, Shunchen Zhou, Bosen Zhao, Jiaying Qu, Xiaojing Wang, Liduan Zheng, Qiangsong Tong

Faculty, Staff and Students Publications

Rationale: Neuroblastoma (NB) is a predominant extra-cranial malignancy in childhood, while molecular drivers of its progression and effective treatment strategies have yet to be clarified.

Methods: RNA sequencing was performed to identify transcriptional regulators and corresponding target genes. To explore the biological effects and underlying mechanisms of these regulators, a comprehensive methodology was utilized, encompassing chromatin immunoprecipitation, dual-luciferase reporter assay, qRT-PCR, western blot, alongside gene over-expression and silencing techniques, co-immunoprecipitation, and mass spectrometry. The MTT assay, soft agar colony formation, Matrigel invasion, and nude mouse xenograft models were applied to assess oncogenic properties. Patient survival was analyzed using the log-rank …

Pd-L1-Centric Whole Blood-Based Immune Signature Profiles Of Tuberculosis Patients During Therapy, Johanna Eggeling, Martina Sester, Christoph Lange, Jan Heyckendorf, Barbara Kalsdorf, Anna M Mandalakas, Andrew R Dinardo, David Lewinsohn, Dagmar Schaub, Tina Schmidt, Eva Tolosa, Maja Reimann, Patricia M Sánchez Carballo

Faculty, Staff and Students Publications

This prospective study investigated whole blood-based immune cell biomarkers for pulmonary tuberculosis (TB) immunoprofiling. Blood samples from 34 healthy controls and 51 tuberculosis patients were analyzed at three timepoints: Prior to therapy (T0), after 14 days of therapy (T1), and at the end of treatment (Te). Using multiparameter flow cytometry, 386 immune cell populations were analyzed. Predictive models were developed using two machine learning algorithms. A TB5LF change score, which was based on five cell populations, effectively distinguished tuberculosis patients from controls (AUC = 0.89) and tuberculosis patients before and at the end of treatment (AUC = 0.92). Similarly, the …

‘The Way We Do Our Translation’: A Case Study Of Translation Policy For Spanish Speakers In The Public Parks Of Sonoma County, California, Gabriel González Núñez, Ángel María Casas Grageab, Christina Guerrero Harmon

Writing and Language Studies Faculty Publications

Signs in public spaces can provide essential information. Especially at times of crises, and in places where there are large populations who speak a minoritized language, translation is often employed to create multilingual signage for the benefit of the community. After all, translated signs appear because some authority considers that a certain message is important enough to be visibly communicated to the public, including those who do not speak the State’s preferred language. The decision as to whether to translate or not certain signs may seem arbitrary, but one would hope that it is the result of a guided policy …

Applied Machine Learning In Mineral Prospectivity Mapping In The South Pass-Granite Mountains Of Wyoming, Carl D. York

Graduate Theses/Dissertations

The South Pass-Granite Mountains, comprised of Archean to Tertiary rocks embedded with an Archean greenstone belt in Central Wyoming, have historically been mined for gold, iron, steel, and silver. Rare earth elements have been of increasing interest in the region and thus, several datasets have become available. Knowledge driven and data driven models are used in mineral prospectivity mapping with input data including geological mapping, geochemical data, geophysical (USGS Critical Mineral magnetic and gravity data), radiometric (U, Th, K) data and multispectral remote sensing data. Mineral prospectivity has seen a rapid improvement in recent years using advancements in machine learning …

Drone Dichotomy: Investigating The Application Of Unmanned Aerial Systems For Offensive And Defensive Chemical, Biological, Radiological, And Nuclear-Related Tasks, Evan Jacob Martinovitch

Graduate Theses/Dissertations

This thesis investigates the application of unmanned aerial systems (UAS) for both offensive and defensive chemical, biological, radiological, and nuclear (CBRN) tasks to determine if they serve as a force multiplier on the modern battlefield. As CBRN weapons reemerge as realistic threats alongside the rapid proliferation of UAS, the intersection of these fields presents unique challenges and opportunities. Through a methodology that examines the history of the UAS-CBRN intersection, military doctrine, and the status of UAS technology, this research evaluates the capability of current and emerging UAS against specific CBRN delivery, reconnaissance and surveillance, and decontamination tasks. The analysis conducted …

Nonbinary Gender Performance And Self-Identification In Mary Shelley's Frankenstein, Lillian R. Durr

Graduate Theses/Dissertations

Mary Shelley’s 1818 novel Frankenstein, a text informed by a rich Romantic era philosophical tradition, has produced an expansive contemporary body of transgender studies scholarship. Building on transgender literary studies of Frankenstein, my thesis analyzes the difference between the monster’s internalized self-perceived identity and their externally performed and perceived identity. I interpret the difference between the monster’s internal and external identity as an analogy through which to understand contemporary nonbinary experiences. The “performance” of gender that Judith Butler describes is a limited expression of an internal, inescapable, ontological experience of self-identification. The monster’s own social experience illustrates the …

The Confidence-Man Goes To The Moving Panorama: Herman Melville’S Confidence Narrator And United States Imperialism, Bradley J. Lee

Graduate Theses/Dissertations

This thesis argues that Herman Melville fashioned his novel The Confidence-Man; His Masquerade (1857) after the moving panorama, a popular entertainment technology contemporary with the novel. More specifically, the thesis argues that the novel recalls Banvard’s Mississippi Panorama (1846). Using Jay Leyda’s The Melville Log and John Hanners’ record of Banvard’s performances, I establish beyond reasonable doubt the possibility that Melville saw this painting, or, at the very least, was aware of it, its content, and its social position. Tracing the novel’s engagement with this panorama reveals what seems at first to be its imperialist, Manifest Destinarian undertones. The novel’s …

Small Mammal Communities Within And Land Coverage Around Southwestern Missouri Prairies, Kaitlyn J. Bebensee

Graduate Theses/Dissertations

Land alterations can reduce the amount of suitable habitat necessary for persistence of an associated species. Within such constrained habitats, limited resources may elicit competition, which could cause shifts in abundance and occurrence of species. Missouri prairies have been declining in size, making it imperative to collect reference data on mammal populations within and land use types around remnants. For this study, I trapped small mammals in Southwestern Missouri prairies because they can be indicators of environmental health and can vary in abundance between prairies. I focus on the diet of two dominant small mammals, Peromyscus maniculatus and Microtus ochrogaster …

Northern Luzon In A Taiwan Flashpoint: The Philippines’ Place In U.S. Strategy, Carson Keller

Graduate Theses/Dissertations

While the defense of Taiwan from a potential invasion by the People’s Republic of China (PRC) has long been a topic of debate and scrutiny in U.S. strategic thinking, the role of its southern neighbor, the Philippines, has received far less attention. This thesis argues that northern Luzon would constitute key terrain in a cross-strait conflict and may become an early target of People’s Liberation Army (PLA) operations. Its proximity to Taiwan and position along the Luzon Strait, particularly the Bashi Channel, places it at the center of efforts to control access to the hypothetical battlespace. Drawing on PLA and …

Flow Regime Shifts And Channel Morphological Adjustments In Response To Changing Climate Patterns: Examples From Gasconade River, Missouri, Usa, Katherine E. Brand

Graduate Theses/Dissertations

Recent changes in climate patterns due to anthropogenic inputs (i.e. greenhouse gases/CO₂) have caused alterations to precipitation events leading to altered flow regimes. Changes in the magnitude and frequency of flood events results in physical adjustments to river morphology, including changes in width and depth. As rivers experience more frequent and larger flood events, they accommodate by changing their morphological characteristics. The Gasconade River, a tributary of the Missouri River located in southcentral Missouri, USA, has exhibited recent patterns of acute bank erosion with limited understanding of its causes and effects on the river. This study aims to understand how …

Genomic Signatures Of Decline And Recovery In An Endangered Bat, Myotis Grisescens, Marxe Altman-Orbach

Graduate Theses/Dissertations

Tremendous population declines may result in the loss of genetic diversity, which can, in turn, lead to reduced adaptive potential, overexpression of deleterious phenotypes, and further population declines. In this way, genetic drift from a severe demographic decline may ultimately lead to an extinction vortex. However, populations that avoid the loss of genetic diversity may remain viable, despite demographic crashes. Therefore, understanding genetic diversity is vital for assessing the conservation status of species that have undergone declines, and can even reflect the effectiveness of management actions. I investigated signatures of genetic bottlenecks in the gray bat (Myotis grisescens), …

Inherited Sins: Essays, Claire Ellerman

Graduate Theses/Dissertations

Joan Didion said of her book, The Year of Magical Thinking, that, “the reason I had to write it down, is that no one had ever told me what it was like.” She was trying to make sense of her grief following the death of her husband, and in doing so, wrote a piece of creative nonfiction (CNF) that explores her own life in and around the larger ideas of mourning, connection, and moving forward. This is the ultimate aim of creative nonfiction: writing to make sense of our lives in relation to the world around us. In this …

United States Mainstream Meat Market Entry: An Analysis On Speciality Goat Meat Products, Madison Raye Schmitz

Graduate Theses/Dissertations

Understanding consumers' perspectives and motivations is key when looking into making goat meat more accepted in the mainstream meat market. Previous research has shown there is a demand for goat meat from different populations in the US. Consumers also care more about the quality of the food they purchase. Understanding that goat meat has lower cholesterol and is leaner than other red meat is important to incorporating goat meat in niche consumer markets. Providing consumers with a product that is familiar to them is more acceptable than giving consumers a cut of meat they are unfamiliar with. Standard products like …

Gene Editing And The Accessibility Of Bioterrorism: Rethinking Global Biosecurity In The Post-Covid-19 Era, Nicholas Morales

Graduate Theses/Dissertations

COVID‑19 demonstrated how a single biological event can strain health systems, disrupt supply chains, undermine national security, and erode public trust. This shock occurred as biotechnology became dramatically more accessible: gene editing and synthetic biology tools once limited to specialized laboratories are now widely available through inexpensive equipment, open‑source data, and decentralized expertise.

This expanded access accelerates innovation but also broadens the threat landscape. The ability to reconstruct pathogens using publicly available sequences and mail‑order DNA shows that complex biological synthesis is no longer confined to state programs. These risks are amplified by opaque biotechnology activities in China, Russia, and …

Using 1:1 Behavior-Analytic Instruction To Enhance Outcomes Of A Social-Emotional Learning Curriculum: A Retrospective Single-Case Clinical Evaluation, Cierra Vandermeer

Graduate Theses/Dissertations

Social-Emotional Learning (SEL) is the process through which people acquire and apply skills to manage emotions, form relationships, make responsible decisions, and pursue personal and shared goals, and these competencies shape identity development and daily functioning (Collaborative for Academic, Social, and Emotional Learning [CASEL], 2020). While there are many SEL programs and curricula that exist for school-aged children, there are few curricula that a) have a focus on 1:1 instruction for preschool to primary-aged children, and b) integrate and incorporate Applied Behavior Analysis (ABA) principles. This thesis reviewed a retrospective case study of a six-year-old female-identifying student who participated in …

Eastern Fox Squirrel (Sciurus Niger) Occupancy In A Southern Missouri Woodland, Daniel Garten

Graduate Theses/Dissertations

Species occupancy, which relates the probability of presence of a species at a specific place and time, is an important component of conservation and wildlife management. Principally it is used for estimation of a species’ distribution as well as understanding species interactions and quantifying environmental effects. The purpose of this study was to analyze occupancy of the Eastern Fox Squirrel (Sciurus niger) across multiple seasons (2019–2022) at Bull Shoals Field Station (BSFS), and to identify potential covariates associated with detection and colonization. Data were drawn from camera trap surveys from 26 sites during summer and fall seasons. Multi-season occupancy models …

When Speech Speaks Louder Than Truth: Language Variation And Credibility In The Courtroom, Melanie E. Spinnie

Graduate Theses/Dissertations

This study aims to investigate how linguistic variation affects perceptions of credibility in courtroom settings. It focuses on how jurors, judges, and other individuals in the legal system may exhibit bias (consciously or unconsciously) based on how a defendant or witness speaks-- this could include speech disorders as well as differences in dialect, accent, and speech style. Through review of relevant literature, review of a relevant historical case, conducting a survey, and conducting a semi-structured interview, this study explores whether certain speech patterns or characteristics are disproportionately associated with negative judgments during legal proceedings, such as reduced credibility and trustworthiness. …

Spatial Patterns And Morphometric Evolution Of Sinkholes In Response To Watershed Hydrogeomorphology: Examples From A Karst Landscape In The Missouri Ozarks, Usa, Marcell Tóth

Graduate Theses/Dissertations

Sinkholes are characteristic enclosed depressions with internal drainage connecting the surface and subsurface karst hydrologic system. Their morphological evolution involves gradual subsidence of the ground surface and hazardous collapses. Therefore, understanding sinkhole morphometry and linked spatial distribution is critical for managing geohazards in karst watersheds. Sinkhole occurrence shows spatial variability based on watershed geomorphological attributes, surficial hydrological patterns, hydrogeological and geological settings. The aim of this research is to investigate morphometric properties and distribution of sinkholes in the carbonate karst-dominated lands of Mark Twain National Forest in Missouri, USA. The specific objectives were to (1) identify sinkhole clusters based on …

Experimental Diegetic Thresholds: A Study Of Adapted Carceral Narratives [The] Nickel Boys And Sing Sing, Leslie D. Muench

Graduate Theses/Dissertations

The diegesis is the storyworld of a film, including all the characters, settings, events, and other elements. At certain times, though, that threshold is permeable, particularly when the fictional source material involves lived experiences. Two carceral films model an experimentation with adapted material and the palimpsestuous layering effect that is a result of real-life narratives being transposed into fictional ones. Nickel Boys, directed by RaMell Ross (2024), and Sing Sing, directed by Greg Kwedar (2023), endeavor to humanize a stereotypically ostracized community: Black boys and men who are incarcerated. Through the screenwriting, casting, producing, filming, and sharing of their films …

Confucian Thought As A Strategic Veil: How Western Strategy Should Correctly Compete With China, Owen Miller

Graduate Theses/Dissertations

The rise of the People's Republic of China as a peer competitor to the United States constitutes the defining geopolitical challenge of the twenty-first century, but even so, Western strategic analysis has consistently failed to engage China on its own terms. The recurrent pattern of Western misinterpretation results from projecting Western assumptions onto a state whose institutional and cultural drivers operate under fundamentally different premises, where key elements of Chinese strategic culture and the Chinese Communist Party’s (CCP) instrumentalization of Confucianism as a moral veil are instruments of domestic legitimacy and external strategic narrative. The United States must recognize that …

Europe In The Indo-Pacific - Implications For The United States, Joshua G. Zinicola

Graduate Theses/Dissertations

Within the last five years the Indo-Pacific has become a region of increasing interest to European NATO members. In particular, the United Kingdom, France, and Italy have assigned strategic importance for their national security to the region, signing cooperative agreements with regional allies of the United States and deploying significant forces to the region. These agreements include commitments to jointly develop new technologies and combat systems for employment in both Europe and the Indo-Pacific, such as the Global Combat Air Programme (GCAP), and the Trilateral security partnership between Australia, the United Kingdom, and the United States (AUKUS). They also include …

A Geospatial Assessment Of Groundwater Salinization In A Multi-Aquifer System: Durango, Mexico, Juan Lopez-Sierra

Graduate Theses/Dissertations

Groundwater salinization poses a critical environmental concern for water resource sustainability in arid and semi-arid regions. This study evaluates spatial and temporal patterns of groundwater salinity across the state of Durango, Mexico, using total dissolved solids (TDS), sodium adsorption ratio (SAR), as salinity indicators and nitrate-nitrogen (NO₃–N) as an anthropogenic indicator. Groundwater quality data were obtained from (CONAGUA), a Mexican water agency. To assess salinity variations with respect to time, while minimizing interannual sampling bias, two multi-year sampling periods were selected: 2012-2013, and 2020-2021. Final datasets consisted of 122 wells for 2012–2013 and 131 wells for 2020–2021. The wells were …