Digital Commons Network^™

Voxvista: Enhancing Screen Reading Experience For Online User Comments, Yash Prakash, Akshay Kolgar Nayak, Mohammed Shoaib Alyaan, Sampath Jayarathna, Hae-Na Lee, Vikas Ashok

Computer Science Faculty Publications

Online discussions have become integral to how people exchange ideas, form opinions, and participate in collective deliberation. While sighted users can comfortably engage with online discussions, blind users who are dependent on screen readers are forced to listen to long threads narrated in a single, monotonic voice that lacks prosodic variation, rhythm, or emotion. This robotic auditory experience not only deteriorates the user engagement with the content but also increases cognitive strain, by making it difficult to remain attentive and discern meaning beyond literal words. In an interview study, most blind participants reported that monotonous narration hindered their ability to …

Exploring Marshall–Olkin Models Through Bibliometric And Topic Modeling Approaches Uses Latent Dirichlet Allocation (1981-2025): A Study Based On Scopus Data, Humberto Llinás, Brian Llinás, Carlos López, Daniela Nuñez

Computer Science Faculty Publications

The Marshall–Olkin family of distributions has gained increasing attention in fields such as reliability engineering, survival analysis, financial risk modeling, and actuarial science because of its flexibility in modeling dependence among events and its wide range of extensions. Despite its growing relevance, a systematic understanding of how research on Marshall–Olkin models has evolved over time is still limited. This study addresses this gap by combining bibliometric techniques with topic modeling to analyze the structure and evolution of the scientific literature on Marshall–Olkin models. The analysis includes all 266 peer-reviewed publications on Marshall–Olkin models indexed in Scopus between 1981 and 2025. …

The Deregulation Of Cancer, Daniel G. Aaron

Utah Law Faculty Scholarship

Fifty years ago, the U.S. embarked on a radical new path. Under pressure from the environmental movement, Congress passed an array of statutes aimed at regulating carcinogens out of our world. This regulatory experiment sprawled from air and water to food and consumer products.

Legal scholars have paid scant attention to this wave of cancer regulation despite its size and importance and the public’s apparent interest in avoiding carcinogens. But there is a growing literature finding flaws with individual regimes within the framework, such as the Clean Air Act, the Toxic Substances Control Act, and the Tobacco Control Act. In …

The Crisis In U.S. Cancer Care: Law, Markets, And Privatization, Daniel G. Aaron

Utah Law Faculty Scholarship

Cancer is surging among youth and young adults in the U.S., yet instead of public regulation addressing its root causes, we have outsourced the management of cancer to the private sector.  A suite of laws, embodying faith that corporations will cure cancer, has subsidized the cancer biomedical enterprise and transformed quasi-public institutions into marketized, profit-seeking entities.  These changes, across patent law, healthcare law, innovation law, and Food and Drug Administration (FDA) law, have privatized cancer. 

The market failures I describe in U.S. cancer care raise larger questions about who we entrust with managing critical social problems.  This Article provides theoretical …

Prickle4 Drives Microenvironmental Remodeling And Resistance To Parp Inhibition In Idh-Mutant Glioma, Ju Yang, Hua Yang, Yifan Yuan, Chenyang Zhang, Ziwei Fu, Yanyan Chen, Yinghong Xiong, Shuyu Chen, Kexin Ling, Ying Liu, Jason T Huse, Bo Chen, Timothy A Chan, Zengxin Qi, Zhao Zhang, Xiuping Liu, Yuxiang Wang

Faculty, Staff and Student Publications

Mutations in isocitrate dehydrogenase (IDH) genes sensitize gliomas to PARP inhibition (PARPi) by inducing epigenetic reprogramming of DNA damage repair circuits. However, tumors treated with PARPi eventually relapse despite initial responsiveness. In this study, it is demonstrated that the anti-angiogenic agent lenvatinib synergizes effectively with PARPi, resulting in substantial tumor regression and significantly extended survival. Genomic analysis of tumors reveals that PARPi induces widespread transcriptomic changes that are predominantly pro-inflammatory, thereby promoting tumor angiogenesis. Prickle4, a planar cell polarity protein, is identified as a critical mediator of PARPi-induced neovascularization. Targeting Prickle4 effectively overcomes PARPi resistance in these tumors. Collectively, these …

Grading Melanocytic Dysplasia: Updated Histopathologic Criteria, Christopher R Shea, Victor G Prieto, Catherine M Shachaf, Scott R Florell

Faculty, Staff and Student Publications

Dr. Martin C. Mihm, Jr.'s innovative work on the dysplastic nevus achieved a milestone in his chapter in the World Health Organisation Classification of Skin Tumours (WHO-C). WHO-C presents a dichotomous classification (high-grade versus low-grade dysplastic nevi) and a quantitative metric to assess melanocytic nuclear enlargement. The Duke classification is a related approach that provides mostly quantitative histopathologic criteria for dysplastic nevi and gives due weight to architectural features as well as cytology. This paper proposes and illustrates updated criteria for scoring and grading melanocytic dysplasia, incorporating some of the definitions and categories of WHO-C, while refining the quantitative and …

Clinical And Molecular Characteristics Of Patients With Young-Onset And Average-Onset Pancreatic Adenocarcinoma, Adriana C Gamboa, Kever A Lewis, Laura R Prakash, Zhouxuan Li, Wei Qiao, Dan Zhao, Mark W Hurd, Mahmoud Yousef, Naruhiko Ikoma, Michael P Kim, Jeffrey E Lee, Jessica E Maxwell, Ching-Wei D Tzeng, Matthew H G Katz, Rebecca A Snyder

Faculty, Staff and Student Publications

Purpose: The incidence of young-onset pancreatic cancer (YO-PC) has risen over the past two decades, yet its molecular characteristics and long-term outcomes remain poorly defined.

Methods: We retrospectively evaluated patients with PC treated at a tertiary referral center from 2016 to 2022 who had available molecular data. Patients were classified as YO-PC (≤50 years) or average-onset PC (AO-PC, >50 years). A subset analysis examined outcomes in those who underwent curative-intent pancreatectomy. Primary end points included overall survival (OS) and recurrence-free survival (RFS).

Results: Among 511 patients, 10.9% had YO-PC (n = 56; median age 44 years). Patients with YO-PC more …

Evolving Molecular Subtypes Of Gastric Cancer: From Past Classifications To Present Consensus And Future Directions For Precision Therapy, Ju-Seog Lee

Faculty, Staff and Student Publications

Gastric cancer is a biologically heterogeneous disease. The advent of high-throughput multi-omic technologies has revolutionized our understanding of gastric cancer by deconstructing this heterogeneous entity into distinct and more homogeneous molecular subtypes. Early classifications based on gene expression, methylation, and histology have laid the groundwork for multi-omic frameworks proposed by The Cancer Genome Atlas and Asian Cancer Research Group, which established the foundation of modern molecular taxonomy. Subsequent integrative efforts, particularly the Consensus Genomic Subtypes (Super 6) model, have unified this collected information into clinically relevant subtypes that bridge prognostic stratification with treatment strategies. Established biomarkers such as human epidermal …

Engineering Mutation Clones In Mammalian Cells With Crispr/Cas9, Zijun Huo, Jian Tu, Rachel Shoemaker, Dung-Fang Lee, Ruiying Zhao

Faculty, Staff and Student Publications

CRISPR, Clustered Regularly Interspaced Short Palindromic Repeat, as a powerful genome engineering system, has been widely accepted and employed in gene editing of a vast range of cell types. Compared to zinc finger nucleases (ZFNs) or transcription activator-like effector nucleases (TALENs), CRISPR shows a less complicated process and higher efficiency. With the development of different CRISPR systems, it can be used not only to knock out a gene but also to make precise modifications, activate or repress target genes with epigenetic modifications, and even for genome wide screening. Here we will describe the procedure of generating a stable cell line …

Nsd2 Inhibitors Rewire Chromatin To Treat Lung And Pancreatic Cancers, Jinho Jeong, Simone Hausmann, Hanyang Dong, Kacper Szczepski, Natasha M Flores, Andy Garcia Gonzalez, Liyang Shi, Xiaoyin Lu, Joanna Lempiäinen, Moritz Jakab, Liyong Zeng, Tourkian Chasan, Eric Bareke, Rui Dong, Emma Carlson, Reinnier Padilla, Dylan Husmann, Julia Thompson, Gerry A Shipman, Emily Zahn, Courtney A Barnes, Laiba F Khan, Liz Marie Albertorio-Sáez, Eva Brill, Vishnu Udayakumar Sunita Kumary, Matthew R Marunde, Danielle N Maryanski, Cheryl C Szany, Bryan J Venters, Carolina Lin Windham, Michal Eligiusz Nowakowski, Iwona Czaban, Mariusz Jaremko, Michael-Christopher Keogh, Kang Le, Michael J Soth, Benjamin A Garcia, Łukasz Jaremko, Jacek Majewski, Pawel K Mazur, Or Gozani

Faculty, Staff and Student Publications

NSD2 catalyses the epigenetic modification H3K36me2 (refs. 1,2) and is a candidate convergent downstream effector of oncogenic signalling in diverse malignancies3–5. However, it remains unclear whether the enzymatic activity of NSD2 is therapeutically targetable. Here we characterize a series of clinical-grade small-molecule catalytic NSD2 inhibitors (NSD2i) and show that the pharmacological targeting of NSD2 constitutes an epigenetic dependency with broad therapeutic efficacy in KRAS-driven preclinical cancer models. NSD2i inhibits NSD2 with single-digit nanomolar half-maximal inhibitory concentration potency and high selectivity over related methyltransferases. Structural analyses reveal that the specificity of NSD2i for NSD2 …

Host Modulation Therapy In Periodontitis: From Established Therapies To Emerging Technologies, Aonjittra Phanrungsuwan, Jiaqi Huang, Neeraja Dharmaraj, Alejandra Cobos Perez, Omid Veiseh, Simon Young, Chun-Teh Lee

Faculty, Staff and Student Publications

Periodontitis is a biofilm-induced chronic inflammatory disease, characterized by gingival inflammation and alveolar bone loss. According to a national survey, approximately half of the U.S. adults are affected by periodontal disease. To effectively prevent and treat periodontitis, it is essential to address its underlying causes. The primary etiological factors include polymicrobial synergy and dysbiosis of the oral microbiota, and a dysregulated immune response. The standard therapeutic approach, mechanical removal of biofilm through debridement, sometimes demonstrates limited efficacy, particularly in cases of severe periodontitis, which may require adjunctive or additional therapy. Emerging evidence indicates that periodontal tissue destruction is initiated by …

Blood Flow Regulates Metabolism In Hematopoietic Development, Pamela L Wenzel

Faculty, Staff and Student Publications

Blood flow modifies oxygen availability and biomechanical forces within the vasculature of the embryo as the hematopoietic system develops. The aorta-gonad-mesonephros (AGM) envelops the largest artery in the body and is a critical site for the emergence of hematopoietic stem cells (HSCs). Herein, I discuss the role of hypoxia-inducible factors (HIFs) and force as determinants of metabolism and fate determination. To address the effects of blood flow on hematopoietic development, I employ mouse embryo models and biomimetic culture. Real-time cell metabolic analyses show that oxygen consumption rates (OCR) and extracellular acidification rates (ECAR) are altered by flow in cultures of …

Inclusive Psychology Pedagogy Is Linked To Increased Belonging And Reduced Prejudice Toward Consensually Non-Monogamous Relationships, Rose Bern, Rachel Dinero, Kate Linenbach, Amy Moors

Psychology Faculty Articles and Research

Students enrolled in an elective psychology course entitled Relationship Science, which emphasized inclusive curricula focused on relationship diversity, completed pre- and postcourse assessments of attitudes toward consensually nonmonogamous (CNM) relationships, relationship skills (e.g., constructive communication), and classroom belonging. Given the established literature on lesbian, gay, bisexual, transgender, queer+-inclusive pedagogy, attitudes toward lesbian, gay, bisexual, transgender, queer+ individuals were also measured. Comparisons of pre- and postcourse assessments revealed significant reductions in stigma toward individuals engaged in CNM, alongside increased acceptance of CNM relationships more broadly. Students also reported increases in relationship skills and classroom belonging over the course of the …

Endogenous Processes Underlying Clock-Like Mutational Signatures, Teresa Druck, Rami I Aqeilan, C Marcelo Aldaz, Nicola Zanesi, Kay Huebner

Faculty, Staff and Student Publications

Wellcome Trust scientists have shown that “mutational signatures” in specific nucleotide contexts accumulate in genomes of mammalian tissues, providing clues to underlying causes of specific signatures. Analysis of cancer genomes has identified more than 50 single‐base substitution (SBS) signatures, with SBS1, SBS5, and SBS40 linked to aging and present in normal tissues. SBS1 results from cytosine demethylation, whereas SBS5 and SBS40 arise from unknown endogenous mechanisms. We hypothesized that loss of fragile‐site genes drives these two signatures. FHIT, located at FRA3B, is frequently deleted in cancers, and Fhit‐deficient mouse tissues exhibit a mutation profile resembling human SBS5. Data mining of …

When We Don’T Get Community Right In Restorative Justice Spaces: Cancel Culture And Failure To Transform, Aparna Polavarapu

Scholarly Works

This Article argues that community is a central but deeply misunderstood feature of restorative justice. Restorative justice asks us to understand harm as a break in relationship that creates obligations for the person harmed, the person who caused harm, and the community. Community is theorized to play a key role in working towards reintegration and social change, both goals of restorative justice. Yet in practice, community is often misused or underused in ways that weaken these goals. Practitioners are observing an increase in cancel culture actions by groups that claim affinity with restorative and transformative justice. However, by weaponizing the …

"Tell Me About Your Esol Experience": Exploring Language Journeys Through Shared Stories, Rocio Rivero-Gutierrez

School of Law, Humanities and Social Sciences Theses

This thesis explores the English language learning experiences of ESOL(English for Speakers of Other Languages) participants from southern Spain, examining the interplay between language acquisition, cultural adaptation, andidentity transformation. Grounded in my own ESOL journey — shaped both inSpain and through immersion in an English-speaking context — the studyinvestigates how participants assign meaning to their L2 engagement acrossdiverse social settings, and how English becomes a tool for bothcommunication and personal reinvention. The research adopts a qualitative, narrative-based methodology. The datawere generated through in-depth interviews, small group discussions, andreflective journal entries with nine adult participants, all native Spanishspeakers. Crucially, the data …

Exploring And Increasing Women’S And Girls’ Recreational Ocean Access In A Coastal Community In The Tropical Majority, Florence Barraud

School of Law, Humanities and Social Sciences Theses

Vast gender inequalities restrict women’s and girls’ access to ocean spaces, particularly in the tropical majority. Globally, 68% of women cannot swim, compared to 43% of men. In many coastal communities, women are key stewards of highly biodiverse yet vulnerable marine environments that people rely upon for food security, livelihoods, culture, and coastal protection. Being able to swim is imperative for enabling access to the dominant environment and a core recreational, educational, and economic space. This study aimed to explore and increase women’s and girls’ recreational ocean access in the Maldives, a tropical majority island nation.Utilising a pragmatic feminist approach, …

Safe Family Therapy Activities And The Emotional Well-Being Of Parents Of Autistic Children, Gamze Camci

School of Law, Humanities and Social Sciences Theses

This thesis addresses a critical gap in the existing literature on the emotional well-being of parents of autistic children by applying SAFE family therapy activities grounded in the Narrative Attachment Therapy approach through a three-cycle action research design. Stage 1 involved 3 parents as primary participants, with their children present during selected sessions. Stage 2 included 2 families; the primary focus was on 3 parents across these families. Stage 3 engaged 5 therapists. Data were collected through interviews, diaries, questionnaires and therapy recordings. Data from interviews and journals were analysed thematically, whereas questionnaires were analysed idiographically. The first and second …

Exploring The Reading Motivation And Reading Experiences Of Secondary School Students With Dyslexia In England, Ahmet Kaan Alper

School of Law, Humanities and Social Sciences Theses

This research examines how a small group of secondary school students with dyslexia in England make sense of their reading experiences and motivation to read across school, home and everyday settings. It responds to concerns that literacy policy and practice foreground accuracy, speed and comparison, leaving limited space for reading for pleasure on students’ own terms. Drawing on Michel Foucault’s concepts, the study treats dyslexia and literacy as historically and institutionally produced categories and explores how discourses, norms and accountability regimes shape what counts as legitimate reading and a motivated reader. The research is grounded in a relativist ontology and …

Social And Emotional Experiences Of Higher Education Students With Dyslexia In Türki̇Ye And England: Exploring The Effect Of Context, Levent Yigit

School of Law, Humanities and Social Sciences Theses

This research study examined the social and emotional experiences of university students with dyslexia in Türkiye and England who had received an official diagnosis at some point in their lives. Findings were compared and the differing experiences in two different countries highlighted. Six students in Türkiye and five students in England participated in the study. To produce an in-depth subjective dataset capturing life-stories, a qualitative narrative approach was adopted. Three, and for some participants four, consecutive semi-structured interviews were conducted, with at least a one-week interval between each interview. The study adopted a longitudinal approach as each interview investigated students’ …

Investigation Of A Global Mouse Methylome Atlas Reveals Subtype-Specific Copy Number Alterations In Pediatric Cancer Models., Melanie Schoof, Tuyu Zheng, Martin Sill, Roland Imle, Alessia Cais, Lea Altendorf, Alicia Fürst, Nina Hofmann, Kati Ernst, Dominik Vonficht, Kenneth Chun-Ho Chan, Tim Holland-Letz, Andreas Postlmayr, Ryo Shiraishi, Wanchen Wang, Alaide Morcavallo, Michael Spohn, Carolin Göbel, Judith Niesen, Levke-Sophie Peter, Franck Bourdeaut, Zhi-Yan Han, Yanxin Pei, Najiba Murad, Fredrik J. Swartling, Jessica Taylor, Monika Yadav, Garrett R. Gibson, Richard J. Gilbertson, Matthias Dottermusch, Rajanya Roy, Kornelius Kerl, Rainer Glass, Jiying Cheng, Martin A. Horstmann, Gerrit Wolters-Eisfeld, Haotian Zhao, Dominik Sturm, Viveka Nand Yadav, Louis Chesler, Simon Haas, William A. Weiss, Paul A. Northcott, Lena M. Kutscher, Ana Guerreiro Stucklin, Olivier Ayrault, Julia E. Neumann, Daisuke Kawauchi, David T W Jones, Kristian Pajtler, Ana Banito, Stefan M. Pfister, Ulrich Schüller, Marc Zuckermann

Manuscripts, Articles, Book Chapters and Other Papers

Copy number alterations (CNAs) are hallmarks of cancer, yet investigation of their oncogenic role has been hindered by technical limitations and missing model systems. Here we generated a genome-wide DNA methylation and CNA atlas of 106 genetic mouse models across 31 pediatric tumor types, including 18 new models for pediatric glioma. We demonstrated their epigenetic resemblance to human disease counterparts and identified entity-specific patterns of immune infiltration. We discovered that mouse tumors harbor highly recurrent CNA signatures that occur distinctly based on the tumor subgroup and driving oncogene and showed that these CNAs share syntenic regions with the matching human …

Thwartings, Lee Anne Fennell

Coase-Sandor Institute for Law & Economics Research Paper Series

No abstract provided.

Bibliography On Indigenous Rights In Canada, 1995-2025, Leslie Haddock, Kent Mcneil

All Papers

No abstract provided.

The Intertemporal Law Doctrine’S Application To The Acquisition Of Colonies In The Americas, Kent Mcneil

All Papers

The intertemporal doctrine provides that international disputes have to be resolved in accordance with the international law that existed at the time the events giving rise to the dispute took place, not at the time the matter is adjudicated.1 It is thought to be impermissible to apply current standards to events that occurred in the past when different legal principles and rules were the norm. This doctrine applies as much to acquisition of colonies as to other international issues.2 So in order to determine whether a European nation acquired sovereignty over an overseas territory, it is necessary to determine and …

Nh 4-H Horse Quiz Bowl Packet, Unh Cooperative Extension

UNH Cooperative Extension

No abstract provided.

Ne 4-H Horse Forms And Scoresheets 2026, Hannah Majewski, 4-H

UNH Cooperative Extension

No abstract provided.

Effects Of Density Turbulence On Helicon Wave Propagation In The Core Plasmas, Eun-Hwa Kim, Syun'ichi Shiraiwa, Seung-Hoe Ku, A. Bortolon, Masayuki Ono, Nicola Bertelli, Robert I. Pinsker

Faculty Publications

No abstract provided.

Secondhand Books Industry Between Extinction And Challenges Of The New Millennium: Insights Urban And Architectural Considerations From Al-Azbakeya Book Market., Ahmed M. Selim, Heba M. Gaber, Nehal M. Elmahdy

Mansoura Engineering Journal

At the beginning of the 21st century, the printed and secondhand book industry has faced enormous challenges, particularly after the COVID-19 pandemic, when book consumers sought to engage directly with e-books. The Azbakeya Book Market in Egypt is one of the markets that confronts this challenge, while maintaining its distinctive historical character. This study aims to rehabilitate the secondhand book market in Al-Azbakeya district as a model that simulates the potential urban and sustainable architectural design strategies for reviving this industry. The study framework was comprised into four sections. First, "desk-based research" was conducted to discuss the secondhand book industry …

A Hybrid Geoid Model For The Perlis Region, Malaysia Based On Cadastral Reference Marks And A Geometric Approach, Muhammad Aiman Haiqal Abdul Malek, Muhammad Faiz Pa’Suya, Ramazan Alpay Abbak, Ami Hassan Md Din, Noorfatekah Talib

Mansoura Engineering Journal

This study presents the development of a high-resolution local geoid model for the Perlis region, Malaysia, using a geometric approach that integrates GNSS-levelling benchmarks with Cadastral Reference Mark (CRM) data. A total of 38 GNSS-levelling benchmarks were used as reference points, while 3,725 CRMs were incorporated to significantly enhance spatial coverage for geoid modelling. Orthometric heights at the CRM points were first determined by transferring heights from the reference benchmarks using gravimetric geoid information. Subsequently, geometric geoid heights were computed from the differences between ellipsoidal and orthometric heights. Five interpolation techniques were evaluated to generate the geometric geoid surface, namely …

The Effect Of Second-Order Slip In Hydromagnetic Eyring-Powell Flow: A Bvp4c Study, Ch. Maheswari, B. Naga Lakshmi, G. Dharmaiah, R. Mohana Ramana, B. Reddappa

Mansoura Engineering Journal

The steady-state Eyring–Powell boundary layer fluid flow past a moving surface is examined, considering various parameter implications. These include the wall mass transfer parameter (0.5  C   2.0), the magnetic field parameter (5  Mn 20), the velocity ratio parameter (0.1  λ1  0.7), Eyring-Powell fluid parameters (0.5 K 2 & 0.1 E 0.4), as well as the first-order velocity slip (0.1 γ 1.1) and second-order velocity slip (0.1 δ  0.4). By employing appropriate similarity transformations, the PDEs are reduced to a set of non-linear ODEs, which are subsequently solved using the bvp4c numerical technique and, an implication of key factors on shear …