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Transcriptomic Data And Biomedical Literature Synergize In Finding Pharmacologic Gene Regulators, Cole A Deisseroth, Bess Brazelton, Zahid Shaik, Zhandong Liu, Huda Y Zoghbi Mar 2026

Transcriptomic Data And Biomedical Literature Synergize In Finding Pharmacologic Gene Regulators, Cole A Deisseroth, Bess Brazelton, Zahid Shaik, Zhandong Liu, Huda Y Zoghbi

Faculty, Staff and Students Publications

Most Mendelian disorders caused by a deficiency or excess of one gene product lack targeted therapies. Since these disorders can be modeled with a gene overexpression, knockout, or knockdown, drugs that oppose the transcriptomic effects of such perturbations may be promising therapeutic candidates. RNA-Sequencing (RNA-Seq) studies can fuel this drug-prioritization, but their labels, written in plain language, must be annotated manually. Hence, we introduce Signature-based Networks from Automatically Curated Knockout, Knockdown, and Small-molecule Studies (SNACKKSS), which automatically curates gene-disruption and drug studies from the Gene Expression Omnibus and, in partnership with uniformly computed read count datasets, feeds the labels and …

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Building Belonging, Meera E. Deo Mar 2026

Building Belonging, Meera E. Deo

Denver Law Review

Given the end of affirmative action as we know it, a decline in numeric representation of students of color in higher education seems inevitable—resulting in devastating losses for legal education, the legal profession, and American leadership. Yet those who seek to maintain diverse educational institutions cannot focus their attention solely on cultivating novel admissions strategies. We must couple recruitment with retention. Belonging, a student’s malleable sense of their connection to campus, is a critical tool for improving retention rates as well as academic outcomes and student wellness. Critical Race Theory (CRT) is instructive in this context as a framework that …

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Witness-Washing Facial Recognition Technology, Nathan E. Rouse Mar 2026

Witness-Washing Facial Recognition Technology, Nathan E. Rouse

Denver Law Review

Law enforcement investigations are increasingly driven by hidden algorithmic tools, without disclosure of those tools to the people being prosecuted or the public at large. Facial Recognition Technology, for example, has been used by police to identify suspects in investigations since 2001. Despite the widespread and growing use of Facial Recognition Technology in police investigations, its scientific validity has never been tested in court, and its secret use has prevented it from being challenged on constitutional grounds. This Article coins the term “witness-washing” to describe the mechanism by which this immense evasion has occurred. Witness-washing occurs when law enforcement uses …

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Voting Rights In Kansas After League Of Women Voters V. Schwab, Richard E. Levy Mar 2026

Voting Rights In Kansas After League Of Women Voters V. Schwab, Richard E. Levy

Denver Law Review

Recently, in League of Women Voters of Kansas v. Schwab (League II), the Kansas supreme court addressed the constitutionality of a Kansas statute that purported to combat election fraud. In League II, the court invalidated a provision criminalizing conduct that leads others falsely to believe the actor is an election official, rejected some challenges to a signature verification requirement but remanded for further consideration of others, and upheld a provision limiting the number of ballots that a single person could submit on behalf of others during an election. The decision has important implications not only for voting rights in Kansas …

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Asynchronous Trials: A New Approach To High-Volume Civil Adjudication, Henry Z. Wang Mar 2026

Asynchronous Trials: A New Approach To High-Volume Civil Adjudication, Henry Z. Wang

Denver Law Review

For thousands of years, trials were held in brick-and-mortar courthouses. Then COVID-19 ravaged the world, forcing many businesses and institutions—including courts—to move their operations online. For the first time, many people experienced the benefits of online trials that are held via videoconference software such as Zoom. But Zoom fatigue is real. Now that the pandemic has lessened and courts are no longer urgently adapting to a virtual format, we must more thoughtfully consider what judicial innovations should come next. Outside of the courtroom, this revolution in communication methods has profoundly affected people’s daily lives: we have switched from almost entirely …

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Vol. 102, No. 3: Table Of Contents, Denver Law Review Mar 2026

Vol. 102, No. 3: Table Of Contents, Denver Law Review

Denver Law Review

No abstract provided.

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Using Nuisance Law To Advance Food Safety, Timothy D. Lytton Mar 2026

Using Nuisance Law To Advance Food Safety, Timothy D. Lytton

Denver Law Review

This Essay proposes a novel approach to the most urgent food safety problem currently facing U.S. consumers: fresh produce contaminated with virulent microbial pathogens. Despite extensive regulation, growers have been unable to rid their fields of toxic bacteria, and processors have been unsuccessful in sanitizing tainted produce before it reaches store shelves. As a result, tainted produce sickens millions of consumers every year. An emerging consensus is calling for new efforts to address one source of the problem. Nearby cattle operations produce manure that contains harmful pathogens. When this manure escapes from grazing fields or feed lots—for example, via stormwater …

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Vol. 102, No. 3: Full Issue, Denver Law Review Mar 2026

Vol. 102, No. 3: Full Issue, Denver Law Review

Denver Law Review

No abstract provided.

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Litigating With No Receipts: How The Denial Of Access To Trial Transcripts Denies People The Opportunity To Access Justice, Madisen Zent Mar 2026

Litigating With No Receipts: How The Denial Of Access To Trial Transcripts Denies People The Opportunity To Access Justice, Madisen Zent

University of Cincinnati Law Review

No abstract provided.

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The Mark Of Confusion: Untangling The Circuit Split In Trademark Infringement Jurisprudence, Amilcar Torres Mar 2026

The Mark Of Confusion: Untangling The Circuit Split In Trademark Infringement Jurisprudence, Amilcar Torres

University of Cincinnati Law Review

No abstract provided.

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Broadcasting Bigotry: A Proposal To Revive Group Defamation And Hold Modern Media Accountable For The Disparagement Of Asian Americans, Dominic Roschival Mar 2026

Broadcasting Bigotry: A Proposal To Revive Group Defamation And Hold Modern Media Accountable For The Disparagement Of Asian Americans, Dominic Roschival

University of Cincinnati Law Review

No abstract provided.

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The Disparate Impact Of The California Wildfires On Minority Communities: Exposing Environmental Injustice & Zoning Flaws, Jasmyn Hardin Mar 2026

The Disparate Impact Of The California Wildfires On Minority Communities: Exposing Environmental Injustice & Zoning Flaws, Jasmyn Hardin

University of Cincinnati Law Review

No abstract provided.

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"Tuah Much To Handle": Why The Current Oversight On Cryptocurrency Is Insufficient, Adam Gross Mar 2026

"Tuah Much To Handle": Why The Current Oversight On Cryptocurrency Is Insufficient, Adam Gross

University of Cincinnati Law Review

No abstract provided.

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Virtual Hearings, Tangible Consequences: Rethinking Remote Hearing Rules Adopted Amidst Pandemic Chaos, Elissa Jacob Mar 2026

Virtual Hearings, Tangible Consequences: Rethinking Remote Hearing Rules Adopted Amidst Pandemic Chaos, Elissa Jacob

University of Cincinnati Law Review

No abstract provided.

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To Vacate Or Not To Vacate: Partial Remedies And Mootness In Federal Habeas Of State Convictions, Jeffrey Greenbaum Mar 2026

To Vacate Or Not To Vacate: Partial Remedies And Mootness In Federal Habeas Of State Convictions, Jeffrey Greenbaum

University of Cincinnati Law Review

This Article addresses two related issues in the federal habeas of state convictions. First, it analyzes a circuit split that recently emerged over whether a state’s appeal would be moot after a federal district court grants habeas and a state vacates its own judgment. One view is that the state vacatur would render the appeal moot because the prisoner is no longer in custody. A second view is that the appeal would not necessarily be moot because a partial remedy could be available. Second, this Article identifies some courts conflating the language of a state’s vacatur in habeas and evaluates …

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True Threats And Protected Speech In Counterman V. Colorado, David Crump Mar 2026

True Threats And Protected Speech In Counterman V. Colorado, David Crump

University of Cincinnati Law Review

No abstract provided.

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Civil Rights Microviolations, Alissa Cooley Yonesawa, Michael Kagan Mar 2026

Civil Rights Microviolations, Alissa Cooley Yonesawa, Michael Kagan

University of Cincinnati Law Review

This essay is an attempt to name and define a certain kind of civil rights problem. Namely: Rights violations that are small enough that the rational thing for the victim to do might be to just cope with them, but when allowed to fester and repeat, do significant damage. We call these problems microviolations. To define them, we borrow from the idea of a microaggression, a concept that developed to understand an analogous challenge in workplace and school discrimination. We offer a diagnosis of why microviolations are both problematic and difficult to address, and arguments that they should be a …

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Chartering A New Course: Educational Initiatives Common Among Sc Charter Schools, Julie P. Jones, Paul J. Riccomini Mar 2026

Chartering A New Course: Educational Initiatives Common Among Sc Charter Schools, Julie P. Jones, Paul J. Riccomini

Teacher Education Journal of South Carolina

South Carolina is ranked 24th in the nation for the number of charter schools in the state, with most of these schools opening in the last 10 years. This manuscript analyzes 7 common educational initiatives among SC charter schools: (a) small class size, (b) strong focus on technology, (c) advocating education of the whole child/ arts education, (d) required community service, (e) required parental involvement, (f) uniforms or uniformed dress, and (g) inquiry/project based curriculum. Description and analysis of each component is provided along with specific notes from schools which incorporate it.

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Local Knowledge And Its Implications For Teacher Education In South Carolina, A. Scott Henderson, Cathryn A. Stevens Mar 2026

Local Knowledge And Its Implications For Teacher Education In South Carolina, A. Scott Henderson, Cathryn A. Stevens

Teacher Education Journal of South Carolina

During 2005-2006, the Richard Riley Institute of Government, Politics, and Public Leadership at Furman University conducted focus-group interviews of parents, students, teachers, business leaders, school officials, and district administrators to collect data concerning the state of public education in South Carolina. Analysis of the results suggests that the state’s teacher preparation programs should continue and/or enhance their efforts in the areas of early childhood education, one-on-one tutoring techniques, adult/parent education, reading pedagogies, dropout prevention strategies, and curricular alignment/articulation.

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Constraints To Adopting Locally Based Innovation Systems In Adapting To Climate Change Impacts In Serengeti District, Tanzania, Donald Mwiturubani Mar 2026

Constraints To Adopting Locally Based Innovation Systems In Adapting To Climate Change Impacts In Serengeti District, Tanzania, Donald Mwiturubani

Journal of Humanities and Social Sciences

Smallholder farmers in rural Tanzania depend mainly on rain-fed agriculture, which makes them vulnerable to the impacts of climate change. This paper is based on a study conducted in Burunga and Musati villages in Serengeti District, Tanzania. The study employed a mixed methods approach; combining qualitative and quantitative methods. It involved 154 participants and employed household surveys, key informant interviews, and focus group discussions as data collection methods. The findings suggest that smallholder farmers in the study area are aware of climate change and do, indeed, develop, adopt, and use locally-based innovation systems that avert or minimise its impacts. Smallholder …

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Kafka Proactive Gentuner: Intelligent Self-Optimizing Configuration Tuner With Confidence-Scoring, Kartik Goyal, Diwakar Choudary Mar 2026

Kafka Proactive Gentuner: Intelligent Self-Optimizing Configuration Tuner With Confidence-Scoring, Kartik Goyal, Diwakar Choudary

Defensive Publications Series

[0001] A system and method for managing and optimizing a distributed Apache Kafka production cluster 104. The system 102 collects real-time operational metrics from a plurality of Kafka brokers. The system generates a workload fingerprint and retrieves similar historical fingerprints from a historical case repository. Further, the system identifies top-ranked historical fingerprints using similarity computation. The system generates configuration recommendations if the similarity exceeds a threshold and rejects recommendation generation if the similarity is less than the threshold. Further, the system generates a confidence score for the recommended configuration and compares against a deployment threshold. The system deploys the recommended …

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Doc 2026-08 Proposal To Rename The Department Of Religious Studies To The Department Of Theology And Religious Studies, University Of Dayton. Department Of Religious Studies Mar 2026

Doc 2026-08 Proposal To Rename The Department Of Religious Studies To The Department Of Theology And Religious Studies, University Of Dayton. Department Of Religious Studies

Senate Documents

This proposal outlines the initiative to rename the University of Dayton’s Department of Religious Studies to the Department of Theology and Religious Studies to better reflect the modern academic and public distinction between the two fields. While "religious studies" is now widely understood as a secular, third-person analysis of religion, "theology" refers to the insider study of a faith tradition, which directly aligns with the department's faculty expertise and its explicitly theological MA and PhD programs. Because prospective students and local faith communities increasingly associate the term "religious studies" with purely secular education, the department has faced enrollment losses from …

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A Giving Tree Approach: Balancing Transparency And The Deliberative Process In Judicial Review, Anteo W. Chevere Mar 2026

A Giving Tree Approach: Balancing Transparency And The Deliberative Process In Judicial Review, Anteo W. Chevere

Villanova Environmental Law Journal (1991 - )

No abstract provided.

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The Sortee Guidelines For Data And Code Quality Control In Ecology And Evolutionary Biology, Joel L. Pick, Bethany J. Allen, Benedicte Bachelot, Kevin R. Bairos-Novak, Jack A. Brand, Barbara Class, Tad Dallas, Pietro B. D'Amelio, Erola Fenollosa, Esteban Fernández-Juricic, Dylan G. Gomes, Matthew J. Grainger, Thomas Guillemaud, John Christian, Ruby Krasnow, Malgorzata Lagisz, Sebastian Lequime, Daniel S. Maynard, Shinichi Nakagawa, Rose E. O'Dea, Et. Al. Mar 2026

The Sortee Guidelines For Data And Code Quality Control In Ecology And Evolutionary Biology, Joel L. Pick, Bethany J. Allen, Benedicte Bachelot, Kevin R. Bairos-Novak, Jack A. Brand, Barbara Class, Tad Dallas, Pietro B. D'Amelio, Erola Fenollosa, Esteban Fernández-Juricic, Dylan G. Gomes, Matthew J. Grainger, Thomas Guillemaud, John Christian, Ruby Krasnow, Malgorzata Lagisz, Sebastian Lequime, Daniel S. Maynard, Shinichi Nakagawa, Rose E. O'Dea, Et. Al.

Faculty Publications

Open data and code are crucial to increasing transparency and reproducibility, and in building trust in scientific research. However, despite an increasing number of journals in ecology and evolutionary biology mandating for data and code to be archived alongside published articles, the amount and quality of archived data and code, and subsequent reproducibility of results, has remained worryingly low. As a result, a handful of journals have recruited dedicated data editors, whose role is to help authors increase the overall quality of archived data and code. There is, however, a general lack of consensus around what a data editor should …

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Sentisec: Combining Keyword Heuristics And Sentiment Modeling For Ai-Powered Threat Detection, Ridho Surya Kusuma, Erum Ashraf, Selvakumar Manickam, Shankar Karuppayah Mar 2026

Sentisec: Combining Keyword Heuristics And Sentiment Modeling For Ai-Powered Threat Detection, Ridho Surya Kusuma, Erum Ashraf, Selvakumar Manickam, Shankar Karuppayah

Turkish Journal of Electrical Engineering and Computer Sciences

This work presents SENTISEC, a hybrid LLM-based threat detection framework designed to classify security logs by integrating keyword heuristics, domain-adapted sentiment scoring, and Retrieval-Augmented Generation (RAG). The system achieves an overall accuracy of 93.67%, with 91.46% macro recall, 89.07% macro F1, and 95.15% threat recall, while maintaining a low false-positive rate of 1.68%. Its methodology incorporates strict keyword and IOC matching, a domain-tuned DistilBERT sentiment module, hybrid BM25–MiniLM retrieval enhanced with BGE reranking, adaptive quantile-based threshold calibration, and SHAP-based explainability. Comparative evaluations against keyword-only, sentiment-only, classical machine-learning models, and DistilBERT-only baselines show that SENTISEC consistently improves both true-positive and true-negative …

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The Appropriation Of Indigenous Land In HawaiʻI, Julie Loo Mar 2026

The Appropriation Of Indigenous Land In HawaiʻI, Julie Loo

Walden Dissertations and Doctoral Studies

In the transition from a monarchical to a democratic governance system in Hawaiʻi, Indigenous perspectives have not been fully integrated into land-use decision-making, resulting in mistrust, cultural marginalization, and inequitable policy outcomes. While prior researchers have examined colonization in Hawaiʻi, there is limited understanding of how Hawaiian cultural protocols may impact modern state-level decisions regarding Indigenous land use. The purpose of this qualitative ethnographic case study was to explore perceptions and lived experiences related to the cultural protocol of Kapu Aloha among Kanaka Maoli who participated in the Mauna Kea blockade and government officials involved in permitting Indigenous land for …

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Destabilization Or Clarification: The Potential Impact Of Chiles V. Salazar On Nifla And Other First Amendment Jurisprudence, Zhihan Xu Mar 2026

Destabilization Or Clarification: The Potential Impact Of Chiles V. Salazar On Nifla And Other First Amendment Jurisprudence, Zhihan Xu

Duke Journal of Constitutional Law & Public Policy Sidebar

In 2019, the Colorado General Assembly passed the Minor Conversion Therapy Law (MCTL), a statute which prohibits mental health professionals from engaging in conversion therapy for minors. Three years later, Kaley Chiles, a licensed professional counselor and addiction counselor, filed a pre-enforcement challenge and sought a preliminary injunction, alleging that the MCTL improperly abridges her First Amendment right to free speech. Colorado challenged her claim, arguing that the MCTL merely regulates professional conduct and only incidentally (and permissibly) burdens speech. Chiles v. Salazar will decide whether the MCTL is a speech restriction or professional regulation, and, if it is a …

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Reflections On Judging At The Intersection Of Constitutional Claims And Public Policy, Kimberly J. Mueller Mar 2026

Reflections On Judging At The Intersection Of Constitutional Claims And Public Policy, Kimberly J. Mueller

Duke Journal of Constitutional Law & Public Policy Sidebar

Trial courts play an essential role in our judicial system. At the trial level, lived realities meet legal theories, and generalist judges must resolve constitutional disputes, develop the factual record, and administer justice. However, institutions, especially courts, face increasing pressure. This Keynote Address draws on cases over which I have presided to illustrate how careful process in trial courts helps maintain public trust in our institutions. These experiences reveal three lessons that trial courts teach us. First, the people bringing claims matter; they are real individuals seeking relief by telling authentic stories. Second, pleadings matter because they frame and shape …

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Catherine Lin-Hendel V. Linton Turner Mar 2026

Catherine Lin-Hendel V. Linton Turner

2026 Decisions

USDC for the District of New Jersey

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Unraveling Metabolic Determinants Of Isoniazid Susceptibility In Mycobacterium Tuberculosis, Erin Rilu Wang Mar 2026

Unraveling Metabolic Determinants Of Isoniazid Susceptibility In Mycobacterium Tuberculosis, Erin Rilu Wang

Arts & Sciences Graduate Student Theses and Dissertations

Mycobacterium tuberculosis (Mtb) causes the disease tuberculosis (TB) and is one of the leading causes of death worldwide by an infectious agent. Furthermore, the emergence and evolution of drug resistance has significantly hindered global health efforts to combat this deadly epidemic. Thus, there is a critical need for development of new antibiotics with unique mechanisms of action and design of novel strategies for optimizing the efficacy of existing therapeutic regimens. It is estimated that 10.7% of new infected and 27.2% of previously treated TB cases are resistant to the frontline antibiotic isoniazid (INH), a central component of TB chemotherapeutic regimens. …

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