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Vcp: A Gatekeeper For Intracellular Proteopathic Seeding, Jiang Zhu

Arts & Sciences Graduate Student Theses and Dissertations

Protein inclusions such as β-amyloid, tau, α-synuclein, and TDP-43 are considered the pathologic hallmarks of many neurodegenerative diseases. These proteins are prone to misfold, aggregate, and template new aggregates. Accumulating evidence suggests that those proteins in their high-molecular-weight forms can serve as a "seed", spread through an interconnected brain network, and induce new inclusions. Therefore, it is essential to understand the mechanism of proteopathic seeding. In this dissertation, we performed a whole genomic CRISPR-Cas9 KO screening to identify gene modifiers of αS seeding. Within the screening, we found several hits of endolysosomal function and trafficking, including VCP. VCP is a …

Three Essays On Local Government: Responsiveness, Transparency, And Discriminatory Ordinances, Bryant James Moy

Arts & Sciences Graduate Student Theses and Dissertations

This dissertation explores democratic governance at the local level: responsiveness, transparency, and the emergence of discriminatory policies. First, in Chapter 1, I consider whether citizens in overlapping governing units are represented by their elected officials. In other words, given a patchwork system of overlapping local institutions, can residents direct public policy? To answer this question, I implement a framework that takes into account multiple overlapping governing institutions: cities, counties, school districts, and special districts. In doing so, I create a novel measure of local ideological preferences that varies dynamically. I find that both cross-sectional and dynamic responsiveness exists at the …

Cripping Utopia: Revolutionary Psychocorporealities In Cuba And The Diaspora, Charlotte Emily Merrigan

Arts & Sciences Graduate Student Theses and Dissertations

As a utopian, anti-imperialist project, Cuba’s 1959 Revolution consolidated idealized performances of revolutionary citizenship, in the process regulating ideal forms of embodiment and/or cognition and narrowing the parameters of what good health and productive social reform meant. “Cripping Utopia” therefore challenges the putative able-bodiedness and able-mindedness of the archetypal revolutionary citizen. Throughout the project, I translate and adapt concepts from the historically Anglo-centric field of Critical Disability Studies to the context of the Cuban revolutionary process, from 1959 to the early 2000s. Unlike capitalist or neoliberal societies that make disability into a reason for exclusion or a source of profit, …

The Resilience Of Agro-Pastoral Communities In High Altitude Central Tibet: Zooarchaeological And Stable Isotope Investigations At Bangga, 3000–2200 Bp, Zhengwei Zhang

Arts & Sciences Graduate Student Theses and Dissertations

Our understanding of the development of high-altitude adaptations worldwide has been enriched by recent anthropological research. Study of life on the Tibetan Plateau—dubbed “the Roof of the World”—has highlighted specific challenges of seasonal availability of food and extreme weather systems. Recent archaeological studies have revealed that pastoralism has a long history of resilience on the extreme high altitude Tibetan Plateau. However, specific risks to early flocks on the Tibetan Plateau and ways that herders managed their animals to mitigate these have not been well explored. Dated to 3000–2200 Cal BP, the archaeological settlement of Bangga represents one of the earliest …

Low-Temperature Plasticity Of Rock-Forming Minerals, Michael Keith Sly

Arts & Sciences Graduate Student Theses and Dissertations

The rheology of the Earth’s crust and mantle is in part governed by the physical and mechanical properties of feldspar, quartz, calcite, and olivine. Over the past several decades a significant number of experimental studies have been performed on these minerals. Conventional experiments are generally performed at elevated temperatures because much of the viscoplastic deformation of these minerals is accommodated by high-temperature mechanisms. There is, however, evidence of viscoplastic deformation at lower temperatures (T ≤ 0.3Tm) in the uppermost mantle and throughout the crust. Micromechanical experimental techniques, including nanoindentation and micropillar deformation, can be used to achieve plastic deformation at …

Contribution To Data Science: Time Series, Uncertainty Quantification And Applications, Dhrubajyoti Ghosh

Arts & Sciences Graduate Student Theses and Dissertations

Time series analysis is an essential tool in modern world statistical analysis, with a myriad of real data problems having temporal components that need to be studied to gain a better understanding of the temporal dependence structure in the data. For example, in the stock market, it is of significant importance to identify the ups and downs of the stock prices, for which time series analysis is crucial. Most of the existing literature on time series deals with linear time series, or with Gaussianity assumption. However, there are multiple instances where the time series shows nonlinear trends, or when the …

Application Of Bismuth Oxychloride As A Colorimetric Uv Sensor Material, Kyle James Troche

Nanoscience and Microsystems ETDs

Sunlight contains about 9% UV radiation with roughly one-third of it penetrating the atmosphere and reaching the Earth’s surface. UV radiation from the sun is classified into three different types: UVA (315- 499 nm), UVB (280- 314nm), and UVC (100- 279 nm). Prolonged exposure to artificial UV radiation or direct sunlight can still induce many adverse effects such as sunburn, weakening of the immune system, and skin cancer. A wide variety of photoresistor, photodiode and colorimetric UV sensors are currently being researched to help monitor UV radiation. Our research is focused on developing a colorimetric UV sensor that is inherently …

Constructing Roles And Discourse: Presidential Speech And European Union Accession In The Former Yugoslavia, 2000-2021, John Horner

Dissertations

Yugoslavia’s dissolution in the 1990s resulted in seven distinct nation-states vying for functional institutions, ethno-nationalistic coalescence, and external validation. To this end the European Union (EU) offered a pathway to nation-state building and membership via democratization, economic liberalization, and legal and civil improvements. However, to date only Slovenia (2004) and Croatia (2013) are EU member-states. Montenegro, North Macedonia, and Serbia are candidate countries. Bosnia and Herzegovina and Kosovo are potential candidates. What are the incentives for Western Balkan countries to reform and join the EU? Were motivations driven by rational, economic benefits of membership, or was the impetus identity-oriented to …

Assembly Of The Peripheral Arm Subunits Of Escherichia Coli Complex I And Analysis Of Clinical Mutations, Hind Alkhaldi

Biological Sciences Theses and Dissertations

Respiratory Complex I from E. coli is a proto-type of the mitochondrial enzyme, consisting of a 6-subunit peripheral arm (B-CD-E-F-G-I) and a 7-subunit membrane arm. When subunits E-F-G (N-module), were expressed alone they formed an active complex as determined by co-immunoprecipitation and native gel electrophoresis. When co-expressed with subunits B and CD, only a complex of E-F-G was found. When these five subunits were co-expressed with subunit I and two membrane subunits, A and H, a complex of B-CD-E-F-G-I was membrane-bound, constituting the N- and Q-modules. Assembly of Complex I was also followed by splitting the genes between two plasmids, …

Activation Of P53-Regulated Pro-Survival Signals And Hypoxia-Independent Mitochondrial Targeting Of Tigar By E6 Oncoproteins Of High-Risk Hpvs, Lacin Yapindi

Biological Sciences Theses and Dissertations

The high-risk human papillomaviruses are small, non-enveloped double-stranded DNA viruses that infect the basal epithelial keratinocytes. The majority of HPV infections are self-limiting and asymptomatic; however, in 2-4% of all infected individuals, persistent infections with high-risk HPVs lead to malignancies, including head-and-neck cancers and anogenital carcinomas, particularly cervical cancers. The HPV life cycle is strongly tied to the normal differentiation process of the epithelial tissue. Upon cell entry, the viral genome is maintained as episomal DNA within the nuclei of HPV-infected basal keratinocytes and amplified to a low copy number as the cells divide. As a part of the self-renewing …

2022 Spring Commencement Program For The University Of Arkansas At Little Rock., University Of Arkansas At Little Rock. Records And Registration

Commencement Programs

No abstract provided.

Steps Toward The Total Synthesis Of The Chrysosporazine Family, Katie Kaczynski

Electronic Theses and Dissertations

Cancer is one of the leading causes of death worldwide, with 19.3 million new cancer cases and 10 million deaths in 2020 alone. In the United States, cancer was the second leading cause of death after heart disease. One of the reasons that cancer is so frequently terminal is that cancerous cells frequently develop multidrug resistance (MDR) to frontline chemotherapeutical treatments, resulting in cancers cannot be treated and are inevitably fatal. This makes the discovery of ways to combat MDR so important in the treatment of cancer. The chrysosporazines are a family of recently discovered (2019) natural products that have …

Cultural Beliefs About Healthy And Unhealthy Weight In Children 2 To 11 Years Of Age Among Parents Of Mexican Heritage, Nathalie Confiac

Electronic Theses and Dissertations

Introduction: Despite multisectoral preventive interventions, the obesity prevalence among children of Mexican heritage remains the highest of all ethnic groups in the US. Methodology: Guided by Leininger’s Culture Care Diversity and Universality Theory, this study explored the culture care beliefs and practices of Mexican heritage parents about healthy and unhealthy weight in children 2-11 years of age using the ethnonursing research method. Eight key and 17 general informants were interviewed, and the four phases of ethnonursing data analysis guided analysis. Results: Twenty-six categories were identified which led to seven culture care patterns revealing four themes. Informants shared the …

May 14, 2022, Seattle University School Of Law

Commencement Programs

No abstract provided.

Commencement Convocation Exercises - May 14th 2022, Prairie View A&M University

Commencement and Convocation Exercises

No abstract provided.

Equality Across The Pond: An Analysis Of Marriage Equality Between The United States And The United Kingdom, Angel Santiago

Senior Honors Projects, 2020-current

Throughout history, the United Kingdom (UK) and the United States (US) have faced criticism and backlash for limitations on marriage equality. Within the last two decades, there have been many initiatives put into place to combat the marriage equality dilemma. I will be conducting two case studies on prominent social movements within the US and UK. Within the UK, I will be examining the Stonewall organization and the LGBT Foundation; and within the US, I will be examining the National Lesbian and Gay Journalists Association and National LGBT Chamber of Commerce. This root of the dilemma spurs mainly from human …

Addressing Basic Needs Security At Santa Monica College, Brooke Guelker

Education Policy and Leadership Theses and Dissertations

Basic needs insecurity has gained recognition as a significant barrier to completing a postsecondary credential. Research has shown that students enrolled at community colleges experience basic needs insecurity at rates higher than their four-year counterparts. Given the community college’s expansive mission, it is imperative that these institutions attempt to mitigate basic needs insecurity by identifying innovative solutions tailored to their specific student populations. The original aim of this study was to explore the utility of the planned change framework in understanding how a partnership between a postsecondary institution (Santa Monica College) and a nonprofit organization (Swipe Out Hunger) led to …

Scholarly Interest In Forest Fires In Indonesia: A Bibliographical Review, Eka Wulandari, Djati Mardiatno, Dewi Haryani Susilastuti, Ahmad Maryudi

Forest and Society

Forest fires in Indonesia have attracted much attention among researchers over the past few decades. This paper aims to systematically map the existing corpus of scientific knowledge on forest fires in Indonesia. The systematic maps visualize which areas of significant activity and indicate specific interests and motives. The systematic analysis is also helpful in improving the understanding of current issues, problems, and challenges. From the scientific database of Scopus, we found 209 peer-reviewed journal articles directly related to forest fires in Indonesia published between 1989 and 2021 (July). In general, the number of publications rose after major fire events, notably …

The Pagoda Of The Gods: A Case For Indigenous Karen Sacred Sites As Special Cultural Zones Along Thailand’S Borders, Suwichan Phatthanaphraiwan, Lilly Zeitler, Benjamin Fairfield

Forest and Society

Burgeoning recognition of Indigenous traditional ecological knowledge and livelihood practices have led to ‘Special Cultural Zone’ designations for some traditionally Indigenous lands in Thailand. Simultaneously, the Thai government has designated 10 Special Economic Zones (SEZs) to bolster trade and investments along its borders without acknowledging the pre-existence of Indigenous peoples. SEZs intersect with sites of notable cultural significance, such as Kho Pho Lu (Pagoda of the Gods), a sacred site for Indigenous Karen near Mae Sot in Tak province. Detailed ethnographic and interview findings show the resilience of these sacred sites and embedded ritualistic place-making practices that persist despite a …

The Production Of Safety School Space From Climate Disasters In Doi Mae Salong Forest, Upland Northern Thailand, Maya Dania, Wanwalee Inpin, Reni Juwitasari, Yuki Miyake, Yukiko Takeuchi, Takayoshi Maki

Forest and Society

This research is conducted in Santikhiri, a hilltop village on the highest peak in the Doi Mae Salong forest, where climate change increases the intensity and frequency of natural disasters that immensely affect the local children in the mountainous area in Chiang Rai province, northern Thailand. There is only one secondary-level school in this forest landscape educating around 900 schoolchildren from various minority hill-tribe ethnic groups. This paper examines everyday life experiences recentering the village school's role as the producer of safe space for the forest children from climate disasters. School safety is a global framework for recognizing the importance …

Injustice Against Women In A Social Forestry Program: Case Studies From Two Indonesian Villages, Dadang Anugrah, Andi Vika Faradiba Muin, Irlan Irlan, Muhammad Agung Tomasina, Nurul Azila, Nurhady Sirimorok, Novaty Eny Dungga, Syamsu Alam

Forest and Society

Social forestry programs, aimed to reduce poverty in forest communities while maintaining the forest function, are increasingly incorporating gender issues and responsiveness. By design, social forestry program is supposed to promote justice and equality for forest users, but on the ground discriminatory practices against women are occurring. Drawing case study from two Indonesian villages, this study examined the extent of discrimination against women in the implementation of the state social forestry programs. In-depth interviews, observations, and focused group discussions were conducted to collect the data from the villages to analyze the extent of discriminatory practices by using a social justice …

Agroforestry Rubber Networks And Farmers Groups In Phatthalung Area In Southern Thailand: A Potential For An Innovation Platform?, Eric Penot, Marion Theriez, Isabelle Michel, Uraiwan Tongkaemkaew, Benedicte Chambon

Forest and Society

The study took place in southern Thailand, in Phatthalung province, and is part of “Heveadapt,” a Franco-Thai research project. The aim of this project was to show how smallholder rubber plantations can adapt and remain sustainable in the face of variable climatic conditions and deep changes in socio-economic context. Among the various types of cropping systems, agroforestry practices were identified as promising. Rubber agroforestry systems (AFS) are economically more productive than rubber monocrop plantations and give more flexibility to smallholders, in particular when rubber prices are low, which has been the case since 2013. However, adoption of AFS during the …

Commencement Program: 2022, Governors State University

Commencement Documents and Videos

Sonya Petty and Peter Brassea were the student speakers.

Ramona Hernandez and Brave Fung performed the National Anthem.
Marquis Parks performed "Lift Every Voice and Sing".

Rev. Michael Pfleger was the Honorary Degree recipient.

Hidden Amongst People: Experiences Fo Black White Biracial Individuals With Microaggressions, Horizontal Hostilities, And Identity Denial In Educational Settings, Deborah Luckett

Electronic Theses and Dissertations

This qualitative dissertation explores the dissonance between critical race theory and culturally relevant pedagogical practices in the context of non-binary identity formation and identity denial for Black White Biracial (BWBR) individuals. This positioned subject study examines stories of five adult female members of this population. Utilizing Bell’s Storytelling for Social Justice Model (2020) the study reveals the stock, concealed, resistance and, emerging/transforming stories of participants as they recall experiences with monoracially instigated microaggressions and horizontal hostilities. The model provides analytic themes to examine the dissonance. The following questions will be explored:

Primary Question: What socio/cultural interactions influence BWBR racial identity …

Long-Term Health Outcomes For Adult Women Who Experienced Sexual Assault, Jodie Flynn

Electronic Theses and Dissertations

The purpose of this study is to understand the impact of sexual assault pre- and post-sexual assault on health, health care experience, and health-related quality of life in adult women. Research identifying quality of life as a health outcome post-sexual assault is limited. No long-term studies to evaluate differences in health-related quality of life pre-and post-sexual assault have been conducted. In addition, only a few studies have investigated mental health changes over time. An exploration into self-perceived general health pre-and post-sexual assault and overall current quality of life needs to be conducted to determine improvements in health care services for …

Soymeal Based Bio-Based Adhesive For Wood Application, Prashant Kote

Electronic Theses & Dissertations

Introducing bio-based materials as an alternative to petroleum-based products has been the greatest challenge for the industry which may reduce environmental problems. Currently, most of the wood adhesive is prepared using formaldehyde which is a non-renewable source as well as toxic. In this research, soybean meal was used as a renewable bio-based source for wood adhesive which has a potential to replace formaldehyde-based adhesives. In this study, soymeal was chemically modified, characterized, and evaluated for its adhesion performance, flow behavior, service life, and thermal stability.

In the first, soymeal was modified using acid (HCl), alkali (NaOH), and salt (CaCl_{2 …}

The Catholic Paradox Of Villette, Kevin R. Bie

Senior Honors Projects, 2020-current

Villette, published in 1853, was Charlotte Brontë’s last novel. Brontë explores both narrative and religious complexities through her narrator, Lucy Snowe. Orphaned Lucy Snowe embarks on a new life in a predominantly Catholic country where her Protestant identity is challenged. Catholicism is presented as a temptation for Lucy. Brontë reveals Lucy’s story through her notable fictional autobiography structure, but Lucy Snowe complicates the relationship between narrator and reader. Lucy explicitly capitalizes on the structure of fictional autobiography, critiquing her narration and fostering a personal relationship with the reader.

This thesis analyzes the Catholic paradox in Charlotte Brontë’s Villette by …

From Patrons To Landlords: The Transformation Of Class Relations In Zanzibar Through Wakf Reform, Isabel Spafford

Honors Theses

This study examines the role of wakf reforms in reshaping class relationships in Zanzibar during the British protectorate. Prior to the establishment of the British protectorate in Zanzibar, wakf dedications maintained patron-client relationships between the landowning class and poor clients that were established during the time of slavery but continued after abolition. I argue that wakf dedications were essential to continuing these relationships, and therefore British wakf reforms were necessary to achieve British colonial goals of dissolving patron-client relationships and establishing a capitalist system based on wage labor and ground rent. I analyze the relationship of the British colonial class, …

One-Step Synthesis Of Corn Oil-Based Polyol For Highly Flame-Retardant Rigid Polyurethane Foams, Tenzin Ingsel

Electronic Theses & Dissertations

Rigid polyurethane foams (RPUF), heavily utilized in construction, refrigeration, and the automotive industries, are a significant class of polyurethanes. They can substantially enhance energy efficiency by improving thermal insulation. However, the application of petrochemical sources in polyurethane has raised environmental concerns.

Such concerns call for the development and application of new bio-based polyurethanes to potentially reduce humanity's over-reliance on nonrenewable sources.

In this work, corn oil-based polyol was synthesized via popularized thiol-ene reaction. The obtained polyol was characterized by wet chemistry methods, spectroscopic evaluations, and chromatography. Non-halogenated flame retardants of cost-effective and environmentally friendly nature were incorporated into the polyurethane …

An Interdisciplinary Approach To Understanding Volcanoes And Their Processes, Katherine Cosburn

Physics & Astronomy ETDs

To better understand volcanoes and their processes is important from both a fundamental science perspective and for hazard monitoring purposes. The complexity and limitations we face in pursuing such a science are numerous and this dissertation explores how an interdisciplinary approach combining physics, computer science, and volcanology can address this complexity in a straightforward and meaningful way. This is achieved through various modelling techniques across three studies: (1) a first-order analytic modelling of stratovolcano topographic shape, (2) the use of a Bayesian joint inversion on gravity and novel cosmic-ray muon measurements for imaging flat-lying subsurface density anomalies, and (3) the …