Digital Commons Network^™

Mitophagy-Mediated Regulation Of Ros Homeostasis During Hsc Activation Contributes To Cell Fate, Amber Lynne Smith

Theses and Dissertations (ETD)

The ability of hematopoietic stem cells to self-renew and differentiate is required for the maintenance of all blood lineages under basal physiologic conditions and in response to inflammatory stress. The degradative capacity of the autophagy-lysosomal system is a determinant of hematopoietic stem cell (HSC) activation status with low autophagy predicting activation of HSCs, and autophagy deficiency causing the spontaneous loss of quiescence and HSC exhaustion. Although an increase in mitochondrial activity has been suggested as the cause of HSC depletion in autophagy-defective models, the contribution of mitophagy to HSC function remains to be elucidated. Here, we capitalized on the observation …

Homestead Vegetable And Poultry Production And Related Practices: An Assessment In Nepal, Shiva Bhandari

Theses and Dissertations

Consumption of nutrients-rich foods like diverse vegetables, eggs, and meat throughout a year remains a challenge in low- and middle-income countries due to poor availability, accessibility, and affordability. One important way to overcome the challenge is to promote households’ own production of these foods and encourage individuals to consume. Improving household production of the foods necessitates understanding whether active participation and performance of frontline workers in the communities and performing improved production-related practices can translate into improved production of nutrients-rich foods. This study had two specific aims. The first aim was to examine demographic, socio-economic, and programmatic determinants of active …

Poetic Self-Representation Among Russian And British Female Poets In The Late 18Th And Early 19Th Centuries, Ulyana Brewer

Theses and Dissertations

This study focuses on the development of self-representation by Russian women poets of the end of the eighteenth century and the beginning of the nineteenth century through comparison with the women poets in England of the same period. The comparative analysis of the works composed by Ekaterina Urusova, Aleksandra Murzina, Anna Bunina, Mary Julia Young, Mary Scott, Janet Little, and others provides insight into women poets’ practices of exceeding the boundaries of gender-defined art to inhabit literary discourse traditionally occupied by male poets and expose the artificiality of gender and literary genre relations and engage with a variety of political, …

It’S An Old Song, But We’Re Gonna Sing It Again: The Myth Of Orpheus & Eurydice In Modern And Postmodern Theatrical Performance, Tiffani Brooks Hagan

Theses and Dissertations

Since theatre was established as an art form, productions have adapted myths into performance, creating an array of theatrical texts based on the oral practice of storytelling of ancient civilizations. This concept of adaptation, where playwrights draw from stories of the past in new works, has expanded in recent years to include new scholarship regarding the dramaturgy of theatrical adaptations and what it means to adapt a work, whether originally for theatre or not, into a text meant for theatrical performance. One such myth that has captivated audiences since its first recorded utilization has been the myth of Orpheus and …

How Decision Makers’ Career Histories Impact The Gender Diversity Of The Ceo Successor Candidate Pool, Andre G. Havrylyshyn

Theses and Dissertations

Scholars have explored when/why women are chosen as CEOs, and what factors explain the presence of women in the TMT, but little is known about when/why firms have women executives in their internal CEO successor candidate pool. This omission is consequential, since there are firm performance benefits to having a woman CEO who is an internal hire, and because being a CEO successor candidate helps ensure a woman executive has had skill-building opportunities that will help her thrive when she becomes CEO. To address this, my dissertation explores two research questions. First, when and why do women directors positively impact …

Testing Models Of Context-Dependent Outcome Encoding In Reinforcement Learning, William M. Hayes Iv

Theses and Dissertations

Previous studies of reinforcement learning (RL) have established that choice outcomes are encoded in a context-dependent fashion. Several computational models have been proposed to explain context-dependent encoding, including reference point centering and range adaptation models. The former assumes that outcomes are centered around a running estimate of the average reward in each choice context, while the latter assumes that outcomes are compared to the minimum reward and then scaled by an estimate of the range of outcomes in each choice context. However, there are other computational mechanisms that can explain context dependence in RL. In the present study, a frequency …

Metaphors Of Memory: Complexity And The Fourth Canon, Amber Lee

Theses and Dissertations

This dissertation examines four main sites of memory scholarship (bodily memory, historical and historiographical memory, material memory, and digital memory), arguing that at each site, memory is treated in ways which are inconsistent with most current scholarly understandings of how it operates. Each chapter focuses on one of the major sites of memory scholarship, demonstrating how particular uses of keywords at that site undercut its own attempt to address memory’s complexity. In the process, I lay the groundwork for alternative conceptions of memory in that site that offer new avenues for memory research.

Lost In Translation: The Largely Unknown Life And Contributions Of Johann Joachim Quantz, Kayla Ann Low

Theses and Dissertations

This study aims to determine the flutist and pedagogue Johann Joachim Quantz’s place in the flute’s standard repertoire. I contend there are three main causes for Quantz’s exclusion from the standard repertoire suitable for public performance. 1) Quantz’s legacy has been anachronistically recorded thus affecting our understanding of Quantz and why his music is not in the standard repertoire. Among other factors, Quantz’s autobiography was not published in English until 1951. 2) Quantz’s position as the private teacher of Frederick the Great not only determined, but also stifled his output. 3) Finally, I argue the evolution of the silver flute …

Redistributing Cultural Capital: Graduate Programs In Wind Conducting At Historically Black Universities; Toward An Alternate Future, Jamaal William Nicholas

Theses and Dissertations

The visibility and popularity of marching bands at Historically Black Colleges and Universities (HBCUs) represents a multi-generational tradition of marching and musical excellence. With performances that reach national and international audiences through large viewership, HBCU marching band culture is elevated to artistic prominence with each major league sporting event performance, Presidential inaugural parade, and viral retweet of a performance by a recording artist. After decades of significant contribution to instrumental music education, however, HBCUs have been unilaterally unable to develop graduate programs in wind conducting. Using a qualitative study design, the goal of the current study was to identify challenges …

Discovery And Mechanistic Study Of Novel Pbd-Targeted Inhibitors Of Plk1 For Prostate Cancer Treatment, Danda Pani Chapagai

Theses and Dissertations

Polo-like kinase 1 (PLK1) is a central player in regulating entry into and progression through mitosis. Inhibition of sub-cellular localization and kinase activity of PLK1 through the Polo-box domain (PBD) is emerging as a viable alternative to ATP binding site directed drugs for which the development of resistant mutants and inhibition of closely related members of the PLK family (tumor suppressor roles) are primary concerns. I describe related novel non-peptidic PBD binding inhibitors, termed abbapolins, identified through successful application of the REPLACE strategy and demonstrate their potent antiproliferative activity in prostate tumors and other cell lines. Furthermore, the abbapolins show …

Parent-School Conflict In The Education Of Students With Disabilities: Causation, Prevention, And Resolution, Julie Voyles

Dissertations

Millions of children with disabilities have benefited from the Individuals with Disabilities Education Act (IDEA) (United States Department of Education [USDOE], 2010). However, the law has also been a source of frequent litigation and conflict between schools and parents (Mueller, 2015; Pudelski, 2016). This study was initiated to examine the perceptions of special education directors regarding the effectiveness of alternative dispute resolution practices. Data for this study were acquired using a semi-structured interview guide designed to elicit special education directors’ perspectives on the shared experience of parent-school conflict. Results indicated special education directors utilize three standard practices to prevent or …

A Rare Cause Of Elbow Pain With A Controversial Name, Thomas Munro, Brian Harvey

Posters

History: 13-year-old right hand dominant male presenting with 1-year concerns of bilateral elbow locking, popping, and pain. Right elbow tends to be affected more frequently than left. Patient states that at random, when he is trying to extend at the elbow joint, his elbows will "lock up". He will not be able to extend past this region and has significant pain when this occurs. He has to proceed back into elbow flexion and again try to "push through" into full extension. This will result in a loud pop followed by about 5-10 minutes of pain which slowly resolves. This happens …

Association Of Abnormal Findings On Neonatal Cranial Ultrasound With Neurobehavior At Neonatal Intensive Care Unit Discharge In Infants Born Before 30 Weeks' Gestation., Jennifer Helderman, T Michael O'Shea, Lynne Dansereau, Jennifer Check, Julie A. Hofheimer, Lynne M. Smith, Elisabeth Mcgowan, Charles R. Neal, Brian S. Carter, Steven L. Pastyrnak, Bradford Betz, Joseph Junewick, Heather L. Borders, Sheri A. Dellagrotta, Barry M. Lester

Manuscripts, Articles, Book Chapters and Other Papers

Importance: Cranial ultrasound (CUS) findings are routinely used to identify preterm infants at risk for impaired neurodevelopment, and neurobehavioral examinations provide information about early brain function. The associations of abnormal findings on early and late CUS with neurobehavior at neonatal intensive care unit (NICU) discharge have not been reported.

Objective: To examine the associations between early and late CUS findings and infant neurobehavior at NICU discharge.

Design, Setting, and Participants: This prospective cohort study included infants enrolled in the Neonatal Neurobehavior and Outcomes in Very Preterm Infants Study between April 2014 and June 2016. Infants born before 30 weeks' gestational …

“Whenever We Crossed A Mountain / On This Earth, Yet Another One Appeared”: Circumstantial Poetry In ʿAbd Al-Ghanī Al-Nābulusī’S (D. 1143/1731) Travelogues, Tom J. Abi Samra

Comparative Literature M.A. Essays

This essay identifies an early modern aesthetic that mobilizes the mundane to make a point about the world or the grandiose. Through a close reading of the poetry in the travelogues of the 17th-century Ottoman Damascene scholar ʿAbd al-Ghanī al-Nābulusī (d. 1143/1731), this essay identifies, theorizes, and historicizes early modern Arabic circumstantial verse—what the 19th-century French poet Stéphane Mallarmé calls vers de circonstance. By drawing on Mikhail Bakhtin’s concept of the “chronotope,” this essay shows how the poetry in Nābulusī’s travelogues fits within, and sometimes advances, their linear narrative. If poetry is expected to transcend the chronotope in which …

Unended Middle Passage: The Exhausted Flesh Of A Resistant Enslaved Woman, Yipu Su

Comparative Literature M.A. Essays

The supine position that characterized the existence of the captive Africans on the slave ship, “The Brookes,” haunted the two female autobiographers of the two mid-nineteenth-century slave narratives/autobiographies this essay discusses. Both Sojourner Truth and Harriet Jacobs voluntarily adopted the supine position as their status of living when resisting sexual violence in slavery, which nevertheless exhausted their flesh. This essay draws on Hortense Spillers’ theory of flesh/body antithesis and Saidiya V. Hartman’s theory of gender construction in slavery to discuss the nature of intended exhaustion. This essay examines to what extent was the strategy of intended exhaustion efficient for both …

Federal Sentencing Guidelines: The Continuous Line Between Unwarranted Disparities And Institutional Discretion In Federal Sentencing, Miaya Scott

Research Papers

In 1984, the Federal Sentencing Reform Act was signed into law. This act of reformation set a new standard of mandatory minimum federal sentencing guidelines for anyone who was convicted of an unlawful crime. Under the Federal Sentencing Reform Act, Congress created a new agency, the United States Sentencing Commission. As a bi-partisan, independent agency, the United States Sentencing Commission set the standard of guidelines with the objective to decrease unwarranted disparities within the federal system. Federal Supreme Court cases like United States v Booker overturned federal guidelines moving them mandatory to advisory based on a Sixth Amendment violation. With …

Targeting Calcium-Mediated Inter-Organellar Crosstalk In Cardiac Diseases, Mohit M Hulsurkar, Satadru K Lahiri, Jason Karch, Meng C Wang, Xander H T Wehrens

Faculty, Staff and Students Publications

INTRODUCTION: Abnormal calcium signaling between organelles such as the sarcoplasmic reticulum (SR), mitochondria and lysosomes is a key feature of heart diseases. Calcium serves as a secondary messenger mediating inter-organellar crosstalk, essential for maintaining the cardiomyocyte function.

AREAS COVERED: This article examines the available literature related to calcium channels and transporters involved in inter-organellar calcium signaling. The SR calcium-release channels ryanodine receptor type-2 (RyR2) and inositol 1,4,5-trisphosphate receptor (IP

EXPERT OPINION: Enhanced SR calcium release via RyR2 and reduced SR reuptake via SERCA2a, increased VDAC and MCUC-mediated calcium uptake into mitochondria, and enhanced lysosomal calcium-release via lysosomal TPC and TRPML …

Generation Of Crispr-Cas9-Mediated Genetic Knockout Human Intestinal Tissue-Derived Enteroid Lines By Lentivirus Transduction And Single-Cell Cloning, Shih-Ching Lin, Kei Haga, Xi-Lei Zeng, Mary K Estes

Faculty, Staff and Students Publications

Human intestinal tissue-derived enteroids (HIEs; also called organoids) are a powerful ex vivo model for gastrointestinal research. Genetic modification of these nontransformed cultures allows new insights into gene function and biological processes involved in intestinal diseases as well as gastrointestinal and donor segment-specific function. Here we provide a detailed technical pipeline and protocol for using the CRISPR-Cas9 genome editing system to knock out a gene of interest specifically in HIEs by lentiviral transduction and single-cell cloning. This protocol differs from a previously published alternative using electroporation of human colonoids to deliver piggyback transposons or CRISPR-Cas9 constructs, as this protocol uses …

Perturbed Hematopoiesis In Individuals With Germline Dnmt3a Overgrowth Tatton-Brown-Rahman Syndrome, Ayala Tovy, Carina Rosas, Amos S Gaikwad, Geraldo Medrano, Linda Zhang, Jaime M Reyes, Yung-Hsin Huang, Tastuhiko Arakawa, Kristen Kurtz, Shannon E Conneely, Anna G Guzman, Rogelio Aguilar, Anne Gao, Chun-Wei Chen, Jean J Kim, Melissa T Carter, Amaia Lasa-Aranzasti, Irene Valenzuela, Lionel Van Maldergem, Lorenzo Brunetti, M John Hicks, Andrea N Marcogliese, Margaret A Goodell, Rachel E Rau

Faculty, Staff and Students Publications

Tatton-Brown-Rahman syndrome (TBRS) is an overgrowth disorder caused by germline heterozygous mutations in the DNA methyltransferase DNMT3A. DNMT3A is a critical regulator of hematopoietic stem cell (HSC) differentiation and somatic DNMT3A mutations are frequent in hematologic malignancies and clonal hematopoiesis. Yet, the impact of constitutive DNMT3A mutation on hematopoiesis in TBRS is undefined. In order to establish how constitutive mutation of DNMT3A impacts blood development in TBRS we gathered clinical data and analyzed blood parameters in 18 individuals with TBRS. We also determined the distribution of major peripheral blood cell lineages by flow cytometric analyses. Our analyses revealed non-anemic macrocytosis, …

Crime Doesn't Pay But Neither Can Ex-Offenders: A Comparative Analysis Of Criminal Restitution In The United States And Canada, Justin Gendler

Cardozo International & Comparative Law Review

The note argues that the U.S. criminal restitution system is flawed, prioritizing punishment over rehabilitation, leading to significant hardships for indigent offenders, victims, and society. It proposes reforming the system to focus on disgorgement of ill-gotten gains and consider offenders' financial situations, drawing lessons from Canada's more rehabilitative approach.

Advance To The Nearest Dispensary: How Quebec's Marijuana Monopoly Is A Model For Future Legalized States, Jason Levine

Cardozo International & Comparative Law Review

The note argues that a state-run monopoly model for marijuana sales, inspired by Quebec's approach, could more effectively promote public health and reduce black-market competition compared to the current license authorization model used in U.S. states like Colorado and California. By centralizing control over pricing, distribution, and product regulation, a monopolistic structure could address challenges such as high taxes, slow transition phases, and the dominance of illegal markets. The analysis draws parallels to alcohol sales frameworks and highlights how a government-run system could avoid federal tax burdens under Section 280E of the Internal Revenue Code.

Duty To Rescue In The Digital Age: A Comparative Analysis, Cameron Kellett

Cardozo International & Comparative Law Review

The article advocates for the enactment of state legislation establishing a duty-to-rescue doctrine, arguing that the absence of such a legal duty leads to preventable harm and undermines societal solidarity. It critiques the arbitrary nature of the special relationship exception under current law and proposes Minnesota's duty-to-rescue statute as a model for reform. The analysis emphasizes that requiring bystanders to provide reasonable assistance, without endangering themselves, is both feasible and morally justifiable, as it aligns with human tendencies to help others in distress.

Sex Work Is Real Work: The Implications Of U.S. Strippers Winning The Right To Unionize, An International Comparative Study, Katherine Fustich

Cardozo International & Comparative Law Review

The note examines the landmark NLRB decision in *Nolan Enterprises*, which granted U.S. strippers the right to unionize by classifying them as employees rather than independent contractors. This ruling has significant implications for labor rights in the sex work industry, both domestically and internationally. The analysis compares this development with international perspectives from the UK, Germany, and the Netherlands, highlighting the challenges and opportunities for sex worker unionization and the broader implications for labor movements globally.

Student Perspectives

Cardozo Journal of Equal Rights & Social Justice

No abstract provided.

Leveling The Playing Field In Custody Proceedings In New York City Family Court: Enforcing The Rights Of All Parents To Notice And An Unbiased Opportunity To Enforce Their Fundamental Right To Parent Their Child, Dana Gambardella

Cardozo Journal of Equal Rights & Social Justice

The note argues that the Administration for Children's Services (ACS) in New York City systematically fails to notify non-respondent fathers, particularly Black fathers, of their rights and opportunities to participate in child welfare proceedings. This practice violates their fundamental constitutional right to parent and disproportionately affects low-income Black families, perpetuating racial and economic disparities in the child welfare system. The note advocates for systemic reforms, including increased accountability for ACS and the establishment of a private right of action for aggrieved parents.

How The Farm Bill May Be The Key To Healthier Cities, Fatima Ouedraogo

Cardozo Journal of Equal Rights & Social Justice

The note argues that the Farm Bill, a significant piece of U.S. legislation governing agricultural and food programs, can be a crucial tool in addressing urban health issues by making healthy food more affordable. By expanding subsidies to include specialty crops like fruits and vegetables, the Farm Bill could reduce the cost of these items, thereby encouraging healthier diets and combating rising obesity rates in urban populations.

The Ballad Of The "White" Collar Criminal: An Examination Of The Intersection Of Race And Gender In Federal White-Collar Sentencing And Possible Implications Of The Findings, Taylor Tesher

Cardozo Journal of Equal Rights & Social Justice

The note argues that racial and gender disparities exist in federal white-collar crime sentencing, particularly affecting Black women, who often receive harsher sentences compared to their white counterparts. It highlights cases like Felicity Huffman and Kelley Williams-Bolar to illustrate these disparities and calls for reforms to address the lack of transparency and consistency in sentencing.

Blackouts And Holes: Analyzing Cross-Market Geographic Mergers In The Healthcare Services Market, Hankyul Song

Cardozo Journal of Equal Rights & Social Justice

The note examines the impact of hospital mergers, particularly crossmarket mergers, on healthcare costs and competition. It argues that while such mergers may offer efficiencies, they often lead to increased bargaining power for hospitals, higher prices for healthcare services, and reduced competition. The analysis highlights the challenges antitrust authorities face in assessing the anticompetitive effects of crossmarket mergers, as current legal and economic frameworks do not fully account for these complexities. The note advocates for a more nuanced approach to evaluating mergers and suggests expanding the scope of antitrust analysis to better address these issues.

Predicting Resilient Modulus Of Unbound Granular Base/Subbase Material., Yasser F. Al-Dulaimi, Ahmed M. Awed, Alaa Gabr, Sherif El-Badawy

Mansoura Engineering Journal

This research paper presents the results of modeling the resilient modulus (MR) of unbound granular base/subbase layers by means of the material index properties and stress state. The database employed in this study was collected from literature studies which includes 16 unbound granular materials (nine of them from Virginia, US while the other seven were from different quarries in Egypt). The database includes Liquid limit (LL), plastic limit (PL), plasticity index (PI), weighted PI (WPI), maximum dry density (MDD), optimum moisture content (OMC), passing sieve No. 4 (Pass#4), passing sieve No.200 (Pass#200), and 233 number of MR measurements. Two common …

Bezhigwan Ji-Izhi-Ganawaabandiyang: The Rights Of Nature And Its Jurisdictional Application For Anishinaabe Territories, Kekek Jason Stark

Montana Law Review

No abstract provided.