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Advances In The Management Of Menopausal Symptoms, Fertility Preservation, And Bone Health For Women With Breast Cancer On Endocrine Therapy, Audrey Messelt, Kristin E Rojas May 2023

Advances In The Management Of Menopausal Symptoms, Fertility Preservation, And Bone Health For Women With Breast Cancer On Endocrine Therapy, Audrey Messelt, Kristin E Rojas

Faculty, Staff and Students Publications

In patients with hormone receptor-positive early-stage breast cancer, adjuvant endocrine treatment administered for up to 5-10 years after diagnosis significantly reduces the risk of recurrence and death. However, this benefit comes with the cost of short- and long-term side effects that may negatively affect patients' quality of life (QoL) and treatment adherence. Among them, the prolonged estrogen suppression associated with the use of adjuvant endocrine therapy in both premenopausal and postmenopausal women can induce life-altering menopausal symptoms, including sexual dysfunction. Moreover, a decrease in bone mineral density and an increased risk of fractures should be carefully considered and prevented whenever …

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Assessing The Applicability Of A Three-Minute All-Out Swimming Test In Collegiate Swimmers, Luis Rodriguez-Castellano May 2023

Assessing The Applicability Of A Three-Minute All-Out Swimming Test In Collegiate Swimmers, Luis Rodriguez-Castellano

Electronic Theses and Dissertations

Performance tests are used to gauge swimmer fitness and guide training prescription. While some traditional protocols, such as, best average swimming (Bavg) lack scientific support, the three-minute all-out test (3MT) is validated to measure critical speed (CS) and distance capacity above CS (D’) from a single maximal swimming bout. In collegiate swimming, a 3MT could be convenient and time efficient. Yet, issues arise with calculating 3MT parameters. Moreover, anthropometry, resistance training, and stroke technique may influence swimming performance and physiological thresholds including 3MT parameters. Hence, this dissertation focused on evaluating the 3MT parameter calculation methods using the interval and lap …

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Cardiovascular Disease In Central Appalachia, An Exploratory Study Of Behavioral, Community, And Patient-Centered Care Influences, Kristy Gagnon May 2023

Cardiovascular Disease In Central Appalachia, An Exploratory Study Of Behavioral, Community, And Patient-Centered Care Influences, Kristy Gagnon

Electronic Theses and Dissertations

The Central Appalachian region of the United States disproportionately experiences higher rates of cardiovascular diseases (CVD) and associated risk factors. Primary risk factors for CVD include hypertension, hypercholesterolemia, and tobacco use, all of which have the potential to be mitigated through lifestyle behavior changes. Dietary and physical activity practices are the two main driving forces for the development of hypertension and hypercholesterolemia, while tobacco use is a behavioral choice on its own. Subsequentially, shifting lifestyle choices to emphasize healthier living has the potential to reduce CVDs within the Central Appalachian region. Considering behavioral choices are not made in isolation and …

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Perception Of Social Media As Seen By Educational Leadership Online Graduate Students, Todd Emma May 2023

Perception Of Social Media As Seen By Educational Leadership Online Graduate Students, Todd Emma

Electronic Theses and Dissertations

The purpose of this phenomenological study is to understand student perceptions of social media as they relate to the programs of study for online graduate students participating in an educational leadership department (hereafter referred to as EDLR) in Tennessee. As institutions of higher education are being affected by declining enrollments, increasing tuition, rising numbers of nontraditional students, global events, and continuing budget cuts, understanding student perception of the educational experience is a fundamental element for understanding ways to address the uncertain future of higher education. Through a series of in-depth interviews, data were collected and analyzed to provide a framework …

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“It’S Alive!” The Birth And Afterlife Of The Gothic Genre, Tanner Linkous May 2023

“It’S Alive!” The Birth And Afterlife Of The Gothic Genre, Tanner Linkous

Electronic Theses and Dissertations

This thesis explores the development of the Gothic novel in England throughout the eighteenth and nineteenth centuries. This thesis establishes the Gothic as a literary mode of middle-class terror by analyzing Gothic novels within the historical context of the Industrial and Democratic revolutions. This requires an in-depth understanding of politics throughout both centuries and this thesis engages with several sources such as Maggie Kilgour’s The Rise of the Gothic Novel which adds important context to my claims. Additionally, I use several contemporary sources such as Godwin’s Caleb Williams, the writings of Edmund Burke, and On the Pleasure Derived from Objects …

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T. Hanks For Nostalgia: The Power Of Tom Hanks And Film Branding, Jacob Higgs May 2023

T. Hanks For Nostalgia: The Power Of Tom Hanks And Film Branding, Jacob Higgs

Electronic Theses and Dissertations

In March 2020, Tom Hanks announced he had contracted COVID-19 while shooting the Elvis Presley Biopic in Australia. On Instagram, he encouraged fans to take the disease seriously and be aware of how severe of a disease it was. Character brands and nostalgia have been found to foster trust in products and encourage relationships with those brands. Using the lens of nostalgia and uses and gratification to examine Tom Hanks as a character brand, the researcher analyzed five blockbuster films with Tom Hanks as the lead character. The study used narrative thematic analysis to observe Hanks and the depictions of …

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Spin Trapping Behavior Of Some Selected Melatonin Derivatives For Hydroxyl Radicals: A Computational Study, Aaron Caesar May 2023

Spin Trapping Behavior Of Some Selected Melatonin Derivatives For Hydroxyl Radicals: A Computational Study, Aaron Caesar

Electronic Theses and Dissertations

Melatonin (N-acetyl-5-methoxytryptamin, MLT) is a naturally occurring antioxidant which has shown some potential for use as a spin trap. Spin traps react with short lived hydroxyl radicals (HO·) to produce more stable products called spin adducts which may be characterized by electron paramagnetic resonance spectroscopy. However, the relative stability of hydroxyl spin adducts of melatonin derivatives (MLTD) compared to 2-hydroxymelatonin (HO-MLT) has not been examined computationally. Computational studies have been done on four selected MLTD; methylmelatonin (Me-MLT), chloromelatonin (Cl-MLT), cyanomelatonin (CN-MLT), and nitromelatonin (NO2-MLT). Geometry of the structures were optimized at the HF/6-31G(d), cc-pVXZ, (X=D and T) and …

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Neuronal Or Intestinal Knockdown Of C. Elegans Nadk-1 Decreases Oxygen Consumption And Reactive Oxygen Species, Jake Regan May 2023

Neuronal Or Intestinal Knockdown Of C. Elegans Nadk-1 Decreases Oxygen Consumption And Reactive Oxygen Species, Jake Regan

Electronic Theses and Dissertations

Reactive oxygen species (ROS) such as H2O2 can damage cellular components and are formed as a byproduct of mitochondrial oxidative metabolism. Studies using the nematode C. elegans have found that increasing ROS during development or early adulthood can extend lifespan, while increasing ROS during later adulthood normally decreases lifespan. NADPH provides the reducing power for several cellular antioxidants and is synthesized in a two-step reaction from NAD+ with the first step being catalyzed by NAD kinase (NADK). In this study, the effects of knocking down C. elegans cytoplasmic NADK, nadk-1 globally or in a neuron or intestine-specific manner starting from …

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Comparative Characteristics Of Integrin Αdβ2 Binding To Native Fibrinogen And Fibrinogen Modified By Dha Oxidation During Inflammation, Ajibola Ilesanmi May 2023

Comparative Characteristics Of Integrin Αdβ2 Binding To Native Fibrinogen And Fibrinogen Modified By Dha Oxidation During Inflammation, Ajibola Ilesanmi

Electronic Theses and Dissertations

2-ω-carboxyethylpyrrole (CEP) is a product of docosahexaenoic acid (DHA) oxidation, which forms covalent adducts with different proteins. CEP-modified proteins can interact with macrophage receptor, integrin αDβ2. This study aims to compare αDβ2 binding to its physiological ligand, fibrinogen, and CEP-modified fibrinogen, which is formed during inflammation. We hypothesize that modification of fibrinogen changes its ligand-binding properties to integrin αDβ2 which can affect macrophage migration and retention. Recombinant αD I-domain and αDβ2-transfected HEK293 cells were used for the experiments. Using biolayer interferometry, we found that the affinity of αD I-domain binding to fibrinogen-CEP was higher than fibrinogen and inhibited by the …

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A Cultural Approach To Environmental Ethics: Milton, Nietzsche, And Indian Philosophy, Kenneth Lee Koenemann May 2023

A Cultural Approach To Environmental Ethics: Milton, Nietzsche, And Indian Philosophy, Kenneth Lee Koenemann

Open Access Theses & Dissertations

The aim of this M.A. thesis is to explore the way in which cultural factors have influenced humankind's relationship with the natural world, including plant life, animal life, and the ecology of planet Earth as a whole. While quantitative, scientific analysis provides objective evidence of global climate change that is being propelled by human activity, I argue that the religious and philosophical beliefs of individuals and societies has played, continues to play, and will continue to play an indelible role in the way in which humans consider other humans and the natural world at large. I focus primarily on Western …

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A Method For Measuring The Spectral Emissivity Of Metal Powders At Different Temperatures And Applications In Laser Powder Bed Fusion, Emmanuel Levario May 2023

A Method For Measuring The Spectral Emissivity Of Metal Powders At Different Temperatures And Applications In Laser Powder Bed Fusion, Emmanuel Levario

Open Access Theses & Dissertations

Radiation thermometry monitoring methods used in powder bed fusion additive manufacturing (PBF-AM) are becoming increasingly more popular for quality assurance and repeatability. The dynamic nature of the PBF process and a lack of accuracy of metrics being captured for temperature monitoring lend great difficulty in the successful implementation of in-situ monitoring. There is currently no data on the emissivity, a metric used in non-contact temperature measurements, for metal powders used in AM. This work describes a method for measuring the spectral emissivity for metal powder sizes commonly used in AM using a multi-wavelength (MW), FMPI SpectroPyrometer, calibrated within the spectral …

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Iatrogenic Nerve Injuries During Surgeries Of The Neck: A Systematic Review, Tajuldeen Al-Hasani, Jickssa Gemechu, Varna Taranikanti May 2023

Iatrogenic Nerve Injuries During Surgeries Of The Neck: A Systematic Review, Tajuldeen Al-Hasani, Jickssa Gemechu, Varna Taranikanti

Posters

Iatrogenic nerve injuries in the neck can present with a wide spectrum of symptoms ranging from mild pain, numbness, or weakness, to devastating consequences for patients such as permanent irreversible damage, disability, or even death. Surgical interventions in the neck region, especially those requiring radical dissections in the neck carry a significant risk of iatrogenic injury to several vital nerves passing through the neck such as vagus, phrenic, brachial plexus, cervical plexus, and ansa cervicalis.

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Developing And Applying Computational Methods On Biomolecules, Shengjie Sun May 2023

Developing And Applying Computational Methods On Biomolecules, Shengjie Sun

Open Access Theses & Dissertations

Computational biophysics is an interdisciplinary subject that uses numerical algorithms to study the physical principles underlying biological phenomena and processes. Electrostatic interactions play an important role in computational molecular biophysics and their potential impact on disease mechanisms. At distances larger than several Angstroms, electrostatic interactions dominate all other forces, while the alteration of short-range electrostatic pairwise interactions can also have significant effects. The dual nature of electrostatic interactions, being dominant at long-range and specific at short-range, underscores their profound implications for wild-type structure and function. Any disruption of the complex electrostatic network of interactions may abolish wild-type functionality and could …

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The Drive, Marisol Adame May 2023

The Drive, Marisol Adame

Open Access Theses & Dissertations

The Drive is a hybrid-poetry collection containing lyric poems, as well as fiction and non-fiction prose pieces, that explores the impact of different types of misogyny and violence against women, with a particular focus on the phenomenon of digital violence. This collection presents different voices and stories that examine themes of violence against the female body.

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Rising Responsiveness: The Roles And Influence Of U.S-Mexico Borderland Public University Board Leaders On Student Diversity, Daniel Rodriguez Dominguez May 2023

Rising Responsiveness: The Roles And Influence Of U.S-Mexico Borderland Public University Board Leaders On Student Diversity, Daniel Rodriguez Dominguez

Open Access Theses & Dissertations

The study sought to learn how governing boards of public university systems located along the U.S.-Mexico border exercise their roles and influence over matters of student diversity. Traditionally, governing boards have been dominated by older white males and have concentrated their attention on high-level financial issues. In addition, the boards have enacted policies and rules directed to traditional student populations of young white males who earn their bachelor's degrees in four years. This notion is no longer valid and is being challenged by increasingly enrolling diverse communities. Student body composition on campuses nationwide have changed noticeably since the beginning of …

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Determinant Factors In Abortion Support Preceding Dobbs: Has Scotus Left Popular Opinion Behind?, Caden Hall May 2023

Determinant Factors In Abortion Support Preceding Dobbs: Has Scotus Left Popular Opinion Behind?, Caden Hall

Sociology and Criminology Undergraduate Honors Theses

The present research analyzed the Wave 52 dataset of the Pew Research Center’s American Trends Panel to understand public opinions regarding abortion legality and the overturning of Roe v. Wade before the landmark case of Dobbs v. Jackson Women’s Health Clinic. Previous literature has suggested a dissonance between the decisions of the Supreme Court in constitutional interpretation with respect to reproductive rights and the disposition of most Americans towards the subject. However, due to the recency of the Dobbs decision, the large gap in research is still developing. Regression models were run on key variables in tandem with two dependent …

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The Role Of Multiracial Identity On Chronic Health Conditions In The U. S.: Evidence From The Behavioral Risk Factor Surveillance Survey, Anna Ruth Jinlong Wahls May 2023

The Role Of Multiracial Identity On Chronic Health Conditions In The U. S.: Evidence From The Behavioral Risk Factor Surveillance Survey, Anna Ruth Jinlong Wahls

Graduate Theses and Dissertations

Abstract Racial identity as it informs health disparities has largely been examined using monoracial groups and a binary framework. This study, informed by critical race theory and stress process theory, investigates the relationship between multiracial identity and health. Data from the 2021 Behavioral Risk Factor Surveillance Survey, a national telephone survey that collects health data on adult aged respondents, will be analyzed using a set of regression techniques. Specifically, the number of chronic health conditions reported by those identifying with more than one race will be compared to the number of conditions reported by monoracial individuals.

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El Que No Tranza, No Avanza: Exploring The Lived Experiences Of Mexican American Community College Students On The U.S.-Mexico Border In Becoming Philosophers, Manuela Alejandra Gomez May 2023

El Que No Tranza, No Avanza: Exploring The Lived Experiences Of Mexican American Community College Students On The U.S.-Mexico Border In Becoming Philosophers, Manuela Alejandra Gomez

Open Access Theses & Dissertations

The purpose of this phenomenological study is to explore the lived experiences of seven Mexican American community college philosophy students in their journeys to becoming philosophers in the U.S.-Mexico border, between El Paso, Texas, and Ciudad Juárez, Chihuahua, Mexico. Philosophy is one of the least diverse academic fields in the United States (Jones, 2020) and often excludes women and people of color (Alcoff, 2013; Ferrer, 2012; Galea, 2017; Haslanger, 2013 Hutchinson & Jenkins, 2013; Leuschner, 2015; Saul, 2012; Wilson, 2012). Therefore, I examine what it means to be a philosopher to these seven Mexican American students and their processes of …

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Linking Decomposition Reactions In Arctic Soils To Microbial Enzyme Production, Jane Karen Martinez May 2023

Linking Decomposition Reactions In Arctic Soils To Microbial Enzyme Production, Jane Karen Martinez

Open Access Theses & Dissertations

Microbial processes such as soil enzyme production are a major driver of decomposition and a current topic of interest in arctic soils due to the effects of climate warming. Despite the advances in understanding soil enzymes, there are still knowledge gaps regarding the role of enzymes in decomposition. In this dissertation, I addressed three of those gaps in the following chapters: (Ch.2) to explore the location of enzymes within the soil matrix, (Ch.3) to identify peptides matched to soil enzymes produced by microorganisms for organic matter decomposition, and (Ch.4) understand the longevity of enzymes in the soil after microbial production. …

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Carbon Quantum Dots' Effects On The Structure And Function Of Neurodegenerative And Non-Neurodegenerative Associated Proteins, Shima Masoudi Asil May 2023

Carbon Quantum Dots' Effects On The Structure And Function Of Neurodegenerative And Non-Neurodegenerative Associated Proteins, Shima Masoudi Asil

Open Access Theses & Dissertations

Protein folding is an important physical process in which the sequences of polypeptides fold into a three-dimensional biological active structure. Misfolding is the conversion of a protein molecule into a structure unlike the native form, and therefore misfolded proteins have a strong tendency to aggregate and make fibrils. Amyloid aggregation is constituted by misfolded amyloidogenic proteins. Neurodegenerative diseases, such as Alzheimer’s Disease (AD), stem from the abnormal accumulation of harmful proteins, including Amyloid-ß peptides, tau protein, and the presynaptic protein α-synuclein in the nervous system. Alzheimer's disease is the most common neurodegenerative disorder that causes memory and learning deficits and …

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The Impact Of Rule Of Law And Property Rights On Development And Economic Growth: A Comparative Analysis Of Cameroon And Côte D'Ivoire, Raoul Tayou Tayou May 2023

The Impact Of Rule Of Law And Property Rights On Development And Economic Growth: A Comparative Analysis Of Cameroon And Côte D'Ivoire, Raoul Tayou Tayou

Open Access Theses & Dissertations

The issues of economic growth and development occupy a central place in the studies of underdeveloped or developing countries. Many solutions have been proposed, including foreign aid or institutional reforms. This last aspect is the subject of this research, particularly the rule of law and the property rights.Analyzing what is the impact of these two institutions on economic growth and development is at the center of my dynamic. Over a period from 1960 to 2022, I carry out a comparative study of the growth, and development trajectories of two countries in sub-Saharan Africa, which share the same demographics: Cameroon, and …

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Performance Classification Of Ornstein-Uhlenbeck-Type Models Using Fractal Analysis Of Time Series Data., Peter Kwadwo Asante May 2023

Performance Classification Of Ornstein-Uhlenbeck-Type Models Using Fractal Analysis Of Time Series Data., Peter Kwadwo Asante

Open Access Theses & Dissertations

This dissertation aims to assess the performance of Ornstein-Uhlenbeck-type models by examining the fractal characteristics of time series data from various sources, including finance, volcanic and earthquake events, US COVID-19 reported cases and deaths, and two simulated time series with differing properties. The time series data is categorized as either a Gaussian or a Lévy process (Lévy walk or Lévy flight) by using three scaling methods: Rescaled range analysis, Detrended fluctuation analysis, and Diffusion entropy analysis. The outcomes of this analysis indicate that the financial indices are classified as Lévy walks, while the volcanic, earthquake, and COVID-19 data are classified …

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Reflections On Pre-Kindergarten Pedagogical Practices For Latine Preschoolers: An Autoethnography, Cynthia Chavez May 2023

Reflections On Pre-Kindergarten Pedagogical Practices For Latine Preschoolers: An Autoethnography, Cynthia Chavez

Open Access Theses & Dissertations

This personal reflexive account of my experiences as a Latine Pre-K teacher and Instructional Coach represents the adversities that many early childhood education public school teachers face within marginalized public-school campuses. Using myself as the subject and researcher within the context of area public school districts provided the drive to seek social justice for disadvantaged Latine preschoolers in their quest for an equitable footing in public school offerings. Through the participant's lens, I chronicle my experiences as a prekindergarten public-school teacher and later as a multi-district instructional coach using the qualitative methodology of both emotive and analytical/interpretive viewpoints. This genre …

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Sextually Active Youth: A Nationally Representative Study Of Youth Sexting And Peer Influence In The United States, Tori Sciara May 2023

Sextually Active Youth: A Nationally Representative Study Of Youth Sexting And Peer Influence In The United States, Tori Sciara

Master's Theses and Capstones

Purpose: This study aims to better understand adolescent sexting and peer influence in the United States. Sexting is defined as the sending or receiving of sexually explicit or suggestive photos and videos of oneself (Bianchi et al. 2019; Bragard and Fisher 2021; Döring 2014). This study builds upon current adolescent sexting literature by analyzing the impact of gender identity, sexual orientation, pornography consumption frequency, and peer sexting on youth sexting frequency. Methods: Data for this study came from the Technology Facilitated Abuse Survey from the Crimes Against Children Research Center. Respondents were ages 18-28 (N=1982); the sample was slightly older …

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The Rise Of Wavetable Synthesis In Commercial Music And Its Creative Applications, Garrett Norman Scroggs May 2023

The Rise Of Wavetable Synthesis In Commercial Music And Its Creative Applications, Garrett Norman Scroggs

Electronic Theses and Dissertations

Wavetable synthesis is a powerful tool for music creation that helps composers and producers develop their own unique sounds. Though wavetable synthesis has been utilized in music since the early 1980s, advancements in computer technologies in the 2000s and the subsequent releases of software synthesizers in the late 2000s and early 2010s has led to the increased presence of wavetable synthesis in commercial music. This thesis chronicles a historical overview of the use of wavetable synthesis in commercial music and demonstrates the accessibility and power that wavetable synthesis delivers in music creation. The demonstration portion of this thesis features two …

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Activation Of Opa1 Processing In Differentiated Myoblast Cells, Omar Agustin Carrillo May 2023

Activation Of Opa1 Processing In Differentiated Myoblast Cells, Omar Agustin Carrillo

Theses and Dissertations

Mitochondria are eukaryotic cellular organelles that play a role in energy production, apoptosis, integrated stress response, and aging. Mitochondrial dynamics is the physical fusion (interconnection) and fission (fragmentation) of mitochondria within a cell and tightly regulates mitochondrial functions. Optic atrophy 1 (OPA1) is a dynamin-related GTPase located in the inner mitochondrial membrane, and is responsible for inner mitochondrial membrane fusion. OPA1 exists in five isoforms, the two fusion-active long OPA1 (L-OPA1) and the three fusion-inactive short OPA1 (S-OPA1) isoforms. When the transmembrane potential (∆ψm) is aggravated, the inner membrane metalloprotease OMA1 is activated, causing the complete cleavage of L-OPA1 to …

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Directed Energy Weapons And Why States’ Interpretations Of “Armed Attack” And “Armed Conflict” Should Evolve, Andy Moore May 2023

Directed Energy Weapons And Why States’ Interpretations Of “Armed Attack” And “Armed Conflict” Should Evolve, Andy Moore

Journal of Space Law

No abstract provided.

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The Plight Of Valinor: A Historically Informed Perspective On The Future Development Of Space Law And Potential Exercise Of Self-Determination By Human Settlements On Mars, Marshall Mckellar May 2023

The Plight Of Valinor: A Historically Informed Perspective On The Future Development Of Space Law And Potential Exercise Of Self-Determination By Human Settlements On Mars, Marshall Mckellar

Journal of Space Law

No abstract provided.

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Lost (It All) In Space: The Legality Of Extra-Terrestrial Gambling, Robert M. Jarvis May 2023

Lost (It All) In Space: The Legality Of Extra-Terrestrial Gambling, Robert M. Jarvis

Journal of Space Law

No abstract provided.

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Legal Issues For Lunar Orbiting Satellites And Suggested Solutions, Francesca Giannoni-Crystal May 2023

Legal Issues For Lunar Orbiting Satellites And Suggested Solutions, Francesca Giannoni-Crystal

Journal of Space Law

No abstract provided.

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