Digital Commons Network^™

The Anchor: May 2023, Hope College

The Anchor: 2023

The Anchor began in 1887 and was first issued weekly in 1914. Covering national and campus news alike, Hope College’s student-run newspaper has grown over the years to encompass over two-dozen editors, reporters, and staff. For much of The Anchor's history, the latest issue was distributed across campus each Wednesday throughout the academic school year (with few exceptions). In recent years The Anchor moved to monthly print issues and a more frequently updated website. The Anchor is now published in print twice per academic semester. Occasionally, the volume and/or issue numbering is irregular.

An Inquiry Concerning Japanese Yen Interest Rate Swap Yields, Tanweer Akram, Khawaja Mamun

WCBT Working Papers

This paper econometrically models Japanese yen (JPY)–denominated interest rate swap yields. It examines whether the short-term interest rate exerts an influence on the long-term JPY swap yield after controlling for several key macroeconomic variables, such as core inflation, the growth of industrial production, the percentage change in the equity price index, and the percentage change in the exchange rate. It also tests whether there are structural breaks in the dynamics of Japanese swap yields and related variables. The estimated econometric models show that the short-term interest rate exerts an important influence on the long-term swap yield in some periods but …

A Leadership Laboratory: Exploring The Use Of Case-In-Point Pedagogy To Develop Complex Thinking In Leaders, Erica Corley Jackson

Dissertations

Leadership scholars have identified a growing gap between the complexity of 21^st century organizations and the capabilities of individuals in positions of leadership to adequately address these challenges. This gap has contributed to a so-called complexity crisis—a situation in which the demands placed on those in leadership positions increases “at a rate that significantly outstrips the rate at which” leaders are cognitively developing (Rich-Tolsma & Oliver, 2016, p. 1). One way to respond to this growing need for complex adult thinking is through metacognitive development initiatives. However, finding educational methods to promote metacognitive development has proven to be …

Demigod And Delinquent: Percy Jackson And The American Teenager, Katie Weber

Honors Theses

Rick Riordan’s The Lightning Thief, the first novel in the Percy Jackson and the Olympians series, has achieved tremendous success with adolescent audiences nationwide since its original publication in 2005. Despite the widespread success of the books, the critical conversation about the novel and subsequent series remains fairly sparse. The existing critical literature on the series addresses its mythological aspects and adolescents’ reactions to the novel but does not analyze Percy’s status as an adolescent or what the novel suggests about adolescents as a whole through its portrayal of Percy. This thesis first provides an overview of the history of …

A Lost Reference Point: How Placing Our Identities In The State Has Facilitated Social Polarization Among Americans, Dylan Evans

Honors Theses

We are living in a moment of societal breakdown, as America is increasingly plagued with fractious polarization along political and cultural lines. The potential causes of this are complex and exist within a broad spectrum of possibilities, with the potential solutions being even more contentious. However, it is my contention that identity is the central issue here. As people begin to place their identities in a religious devotion to the liberal state as opposed to a transcendent ideal, once simple, agreed-upon premises become harsh divides, and polarization ensues. To fully evaluate how this has happened, and thus how it may …

Implementing Sociocultural And Output-Oriented Pedagogical Practices In The Second Language Acquisition Classroom, Caston Holbrook

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

This portfolio is a product of the courses, literature, compositions, class observations, and reflections included in the Masters of Second Language Teaching (MSLT) program. It contains three principal components: teaching philosophy statements, class observation analysis, and reflective work on second language acquisition pedagogical and assessment practices. The author’s educational and professional background and experience in conjunction with his intentions and plans for the future are also described.

The reflection section demonstrates effective methodological approaches in a language-learning classroom in support of the relevant sociocultural theory and output hypothesis. It is comprised of pertinent and supportive literature reviews and research, along …

In Search Of Effective Second Language Arabic Vocabulary Teaching Strategies: Theory And Implementation, Asmaa Yazidi Alaoui

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

This portfolio is the outcome of the author’s studies in the Masters of Second Language Teaching (MSLT) program at Utah State University (USU) as well as her experience as a graduate instructor of Arabic at the same university.

This work has two main parts. The first comprises the three major components that present the author’s perspectives as a teacher, such as professional environment, teaching philosophy statement and the teaching observation.

The second part demonstrated the author’s research interest that aligned with her teaching perspective as an Arabic teacher. It was a position paper that called for Arabic vocabulary teaching strategies …

Graduate Classes To High School Classrooms: A Collection Of Lesson Plans Aimed At Teaching History Graduate Content To High Schoolers, Christopher Taylor

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

As a high school teacher I wanted to create a project that would help benefit my high school students. My project consists of ten lesson plans that incorporate course material from my graduate classes and developed activities to teach this material in a high school setting. The lessons emphasize religious studies, indigenous studies, and different elements of historical method and theory. Each lesson plan is connected to specific Utah core content and literacy standards. The project also contains two papers that I wrote while completing my studies in graduate school. These give a glimpse into the type of research I …

Becoming “Living Matter”: Alive Things In Octavia Butler’S Xenogenesis Series, Zackary Gregory

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

This project seeks to explore the ways Octavia Butler’s Xenogenesis trilogy complicates humans' understandings of subjectivity and human exceptionalism by challenging the concept of Otherness. Octavia Butler’s Xenogenesis series focuses on adaptability and acceptance of the nonhuman Other by depicting a forced encounter between humans and an alien species called the Oankali. Characters within the series grapple with a dynamic understanding of themselves, having to renegotiate the concept of the Other as they deal with intelligent nonhuman Beings and animate objects. Further, characters in the series are coerced into accepting the transformation of humanity into something other than human as …

Gli3 Is Required For M2 Macrophage Polarization And M2-Mediated Waldenström Macroglobulinemia Growth And Survival, Ava J. Boutilier

Master's Theses and Capstones

The macrophage polarization paradigm has become at the forefront of cancer research in recent years; however, the effects of this phenomenon have yet to be investigated in Waldenström Macroglobulinemia (WM). WM is an indolent, B-cell lymphoma, characterized by increased IgM production and infiltration of the bone marrow niche by malignant cells. Macrophages may polarize to one of 2 phenotypes: M1, which is inflammatory or M2, which is inhibitory. While macrophage polarization is typically investigated as a singular point in time, it is important to understand that M2-type macrophages can switch to an M1 phenotype, or vice versa, based on environmental …

Towards Automation Of Volunteered And Authoritative Bathymetric Data Comparisons, Patrick Debroisse

Master's Theses and Capstones

Towards Automation of Volunteered and AuthoritativeBathymetric Data Comparisons By LT Patrick J. Debroisse, NOAA University of New Hampshire, May 2023 Hydrographic data, including sonar, positioning, and oceanographic data used for sea floor mapping, are used all over the world for many purposes. Large volumes of high-quality hydrographic data are required to create high-accuracy nautical charts and bathymetric models required by national defense, resource management, shipping, and scientific interest groups, among others. However, across the world, the amount of highquality data available is limited. Volunteered Bathymetric Information (VBI) is a relatively untapped data source that could be used in many ways …

Shallow Geothermal Energy Systems In The Northeastern United States: System Distancing And Policy Considerations, Aeowyn Kendall

Master's Theses and Capstones

Climate change is an existential threat to human society, and mitigating some of the worst impacts will require electrifying the energy sector and reaching net zero emissions by mid-century (Intergovernmental Panel on Climate Change, 2018). Geothermal energy, specifically ground-source heat pumps, can help to meet winter heating demand in the Northeastern United States. This technology, as well as the various mechanisms that would aid its expansion, are still underdeveloped but have vast potential. A central factor to consider in energy transition work is how energy decisions are made by people within the context of both social and physical system constraints …

Crystal Plasticity Finite Element Modeling Of Magnesium Alloys And Experimental Characterization Of A Trip High Entropy Alloy, Jacob Weiss

Master's Theses and Capstones

This work presents two crystal plasticity finite element studies on magnesium alloys and an experimental characterization of a high entropy alloy. The first of two crystal plasticity studies presents a high strain rate deformation characterization via a split Hopkinson bar Taylor impact of a WE43 magnesium alloy. This study showed that crystal plasticity finite element modeling (CPFE) was able to model WE43 texture evolution, twin volume fraction along the length of the cylinder, and anisotropy with four different material orientations at high strain rates when compared to experimental data. The second study investigated the Taylor-type model homogenization response of the …

Emotional Distress Claims, Dignitary Torts, And The Medical-Legal Fiction Of Reasonable Sensitivity, Alessandra Suuberg

Journal of Law and Health

Can individuals with a highly sensitive temperament recover in tort for intentional infliction of emotional distress (IIED)? In 2019, an article in the University of Memphis Law Review raised this question, referring to the "Highly Sensitive Person" (HSP) construct in psychology and asking whether the IIED tort’s 'reasonable person' standard discriminates against highly sensitive plaintiffs. Following up on that discussion, the present article considers how the law of IIED has historically treated plaintiffs with diagnosed psychiatric vulnerabilities that are either known or unknown to the defendant. The article also extends this discussion to the law's treatment of temperaments, such as …

Face Off: Overcoming The Fifth Amendment Conflict Between Cybersecurity And Self-Incrimination, Zachary E. Jacobson

Journal of Law and Health

The Founders included the privilege against self-incrimination in the Constitution to protect individual privacy and ensure a fair judicial process. Courts have failed U.S. citizens by neglecting to protect them from compelled unlocking of biometrically encrypted devices. This inaction has created a loophole that contradicts the framework of the privilege against self-incrimination. To correct this mistake courts should reconsider the trend they have set for the Constitution and the Fifth Amendment and consider adopting a forward-thinking cybersecurity lens to conclude that biometric authentication is testimonial. Courts should consider that biometric encryption is akin to a compelled password entry for the …

You Have The Right To Remain Uneducated: The Role Of Lobbying In Subverting Anti-Racist Curricula, Liam Martin

Washington Semester Program

This research paper seeks to explore the relationship between professional political actors and the subject of racism in primary education curricula, specifically in areas with prominent anti-CRT movements. Synthesizing these ideas together, the fully formed research question guiding the development of this paper reads as follows: how does the lobbying industry impact the development of primary education curricula in the United States on the subjects of race and racism, specifically in reference to anti-CRT activism? The extant literature on topics of racism, the institution of lobbying, and primary education in America, led to the development of the following thesis …

Voter Id Laws And Gendered Impacts On Voter Turnout, Jacqueline D. Franolich

Boise State University Theses and Dissertations

Since well before the U.S. presidential election of 2020, voter identification laws have been a topic of discussion amongst politicians, voters, the news media, and scholars. Many have questioned the focus and true reason for their creation, their implementation, their effects and potential unintended consequences. Specifically, many have argued that voter identification laws pose too great a barrier to potential voters to be worth the benefits gained in election security. Since the election of 2020, those discussions seemed to magnify. For example, in a May 2021 speech, President Biden repeated similar assertions made in the past by scholars and activists …

Authoritarian Tendencies In The American Presidency, Erica Serros

Boise State University Theses and Dissertations

This thesis attempts to determine if authoritarian tendencies are becoming more or less prevalent in the modern American presidency. Presidential and authoritarian scholars agree that authoritarianism is trending in a more insidious manner in the modern world and that most democracies today are being subverted more inconspicuously by elected officials. The most powerful checks on the power of the president are Congress and the judicial branch, two institutions that do exercise their constitutionally granted powers in some cases, but do not always exert their power in solidarity, leading to discrepancies in the constraint of the president. The presence of conflict …

The President's Subjective And Objective Legal Obligations, Shalev Gad Roisman

Fordham Law Review

Congress has granted the President enormous power. This is well known, but how we are to assess the legality of exercises of such power still is not. Put simply, there is no clear framework to understand the legality of presidential exercises of statutory power. Scholars have noticed this and, in response, have largely turned to administrative law for guidance. This turn to administrative law is somewhat intuitive but misguided.

Administrative law is a highly reticulated body of law that has developed over decades to regulate executive branch agencies, not the President. It has focused on legitimizing agency power in the …

Predictive Ecology And Management Of Phyllosphere Microbial Communities Through Cross-Scale Synthesis, David W. Armitage, Morgan E. Carter, Robin A. Choudhury, Mitja Remus-Emsermann, Cindy E. Morris, Johan H. Leveau, Linda L. Kinkel, José Pablo Dundore-Arias

School of Earth, Environmental, & Marine Sciences Faculty Publications

Here we summarize the main takeaways from a symposium and hybrid virtual and in-person participatory discussion focused on the challenges of scale in understanding the ecology and management of phyllosphere microbial communities. We provide an overview of the confounding effects of spatial scale on inference in microbial ecology, the spatial organization of microbial interactions in the phyllosphere, advances and remaining gaps in measuring phyllosphere colonization across scales, and the epidemiology in the phyllosphere. We hope to motivate further discussion and the development and adoption of creative approaches to solving the challenges of scale to enhance fundamental understanding and practical management …

The Effect Of Henna And Bleach Treatments On Cocaine Hair External Contamination, Alexandra Dombroski

Student Theses

Hair external contamination is a challenging phenomenon that may compromise hair testing interpretation. Previous research has found that cosmetic hair treatments can decrease concentrations of drugs that are already present in the hair shaft, however little is known about the impact of these treatments on the hair when the drugs are deposited externally. The aims of the present study were to explore how henna and bleach treatments influence cocaine external contamination. Sixteen authentic hair samples were collected from volunteers with varying hair colors and shapes and were confirmed negative for cocaine and benzoylecgonine by a fully validated LC-MS/MS method. Each …

Investigating The Roles Of Lung Epithelial Stat3 In Therapeutically Inducible Resistance To Acute Bacterial Pneumonia., Vikram V. Kulkarni, Vikram V. Kulkarni

Dissertations and Theses (Open Access)

Investigating the roles of lung epithelial STAT3 in therapeutically inducible resistance to acute bacterial pneumonia.

Vikram Vitthal Kulkarni, M.S.

Advisory Professor: Scott Evans, MD.

The lung epithelium is a dynamic tissue capable of displaying structural and functional plasticity in response to pathogenic challenges. Our lab has demonstrated that it is possible to therapeutically exploit the lung epithelium’s versatility by inducing resistance to lethal pneumonias caused by viruses, bacteria and fungi. An inhaled combination of a TLR2/6 agonist and a TLR9 agonist (Pam2ODN) results in robust protection against otherwise lethal pneumonia caused by Pseudomonas aeruginosa. Pam2ODN-mediated protection requires key signaling …

The Cx3cl1-Cx3cr1 Chemokine Axis Contributes To Tumor Immune Evasion And Its Blockade Enhances Responses To Anti-Pd-1 Immunotherapy, Apoorvi Chaudhri

Dissertations and Theses (Open Access)

CX3CL1 secreted in the tumor microenvironment serves as a chemoattractant playing a critical role in metastasis of CX3CR1 expressing cancer cells. While CX3CR1 can be expressed in both cancer and immune-inhibitory myeloid cells to facilitate their migration, the mechanisms employed by this axis on these cells to mediate immune suppression remain poorly understood. Here, we explore the immune evasion strategies implemented by this axis and find that it initiates a resistance program in cancer cells that results in 1) facilitation of tumor cell migration, 2) secretion of soluble mediators to generate a pro-metastatic niche, 3) secretion of mediators to attract …

Uncovering Molecular Targets To Overcome Immunosuppression In Non-Small Cell Lung Cancer With Acquired Tki Resistance, Sonia A. Patel

Dissertations and Theses (Open Access)

Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related deaths worldwide. Targeted therapeutic agents, such as epidermal-like growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) or monoclonal antibodies targeting vascular endothelial growth factor (VEGF/R), can effectively inhibit upregulated signaling pathways driving tumorigenesis in NSCLC and many other cancers. Unfortunately, however, resistance to such targeted therapies inevitably arise in most patients and can occur through a variety of resistance mechanisms including genomic alterations and upregulation of bypass pathways. Additionally, patients who have acquired resistance to these targeted agents typically have tumors characterized by an immunosuppressive tumor microenvironment and thus …

Kir-Based Inhibitory Cars Overcome Car-Nk Cell Trogocytosis-Mediated Fratricide And Tumor Escape, Ye Nmn Li

Dissertations and Theses (Open Access)

Trogocytosis is an active process that transfers surface material from targeted to effector cells. Using multiple in vivo tumor models and clinical data, we report that chimeric antigen receptor (CAR) activation in natural killer (NK) cells promoted the transfer of the CAR-cognate-antigen from tumor to NK cells, resulting in (1) lower tumor antigen density, thus impairing the ability of CAR-NK cells to engage with their targets, (2) induced self-recognition and continuous CAR-mediated engagement, resulting in fratricide of trogocytic antigen expressing NK cells (NK^TROG+) and NK cell hyporesponsiveness. This phenomenon could be offset by a dual-CAR system incorporating both …

Adipocytes And Innate Immunity In Systemic Sclerosis, Nancy Wareing

Dissertations and Theses (Open Access)

Systemic sclerosis (SSc; scleroderma) is a chronic systemic autoimmune and connective tissue disorder characterized by vasculopathy, autoimmune phenomena, and widespread fibrosis. Skin thickening and tightening is the cardinal feature of SSc and is responsible, in part, for the considerable morbidity of this disease. There are currently no targeted treatments for skin manifestations in SSc, primarily due to our fragmented understanding of its pathophysiologic mechanisms. In PART I, we report a previously unappreciated link between aberrant expression of the developmental gene sine oculis homeobox homolog 1 (SIX1) in skin-associated adipocytes in SSc skin and the early loss of dermal white adipose …

The Diagnostic Odyssey Of Hypermobile Eds Patients: Diagnosis, Clinical Expectations, And Psychosocial Concerns, Madeline Alpar

Dissertations and Theses (Open Access)

Background: Ehlers-Danlos syndrome (EDS) is a highly variable, heritable connective tissue disorder. Hypermobile EDS (hEDS) is the most common subtype of EDS and has no identifiable underlying genetic etiology. Patients with clinical features of hEDS face a long diagnostic odyssey due to lack of genetic testing and wide clinical heterogeneity. Additionally, recent research has shown that genetic institutions limit evaluations for suspected hEDS, adding another barrier to care.

Methods: We developed an online patient survey to explore the diagnostic odyssey of hEDS for those who were diagnosed with or suspicious for hEDS. This survey included sections on demographics, diagnostic information …

Y Chromosome Gene Kdm5d Epigenetically Drives Sex Differences In Colorectal Cancer, Jiexi Li

Dissertations and Theses (Open Access)

Sex exerts a profound impact on cancer incidence, spectrum and outcomes, yet the molecular genetic bases of such sex differences are ill-defined and presumptively ascribed to X-chromosome genes and sex hormones. Such sex differences are particularly prominent in colorectal cancer (CRC) where men experience higher metastases and mortality. A murine CRC model, engineered with an inducible transgene encoding oncogenic mutant KRAS^G12D and conditional null alleles of Apc and Trp53 tumor suppressors (designated iKAP), revealed higher metastases and worse outcomes specifically in males with oncogenic mutant KRAS (KRAS*) CRC. Integrated cross-species molecular and transcriptomic analyses identified Y-chromosome gene histone demethylase …

Bayesian Semi-Mechanistic Dose-Finding Designs For Phase I Oncology Trials, Chao Yang

Dissertations and Theses (Open Access)

Bayesian adaptive designs are getting more popular in research and in practice because they are flexible and efficient in evaluating an experimental drug. In oncology, despite the great advances in novel dose-finding designs, the high failure rates of clinical cancer drug development from phase I to III trials call for further improvements on novel designs, in addition to the need to promote and adopt novel designs in practice. Because anticancer agents often have a narrow therapeutic index, an accurate identification of the maximum tolerated dose (MTD) in a phase I trial is crucial for identifying a tolerable and efficacious dose …

Impact Of Recent Abortion Legislation On Patient Trust In Healthcare Providers, Jasmine Tyson Ms

Dissertations and Theses (Open Access)

Trust is a key aspect of any patient-provider relationship as patients must rely on their healthcare providers (HCPs) to provide appropriate care and guidance, maintain confidentiality, and act in their best interests. Studies suggest that recent changes to abortion legislation have resulted in a loss of the patient-physician relationship, with individuals describing feelings of isolation and fear regarding safety and confidentiality, and many seeking information outside of the medical community. An anonymous survey was distributed among members of abortion support groups and advocacy organizations in the United States to assess how recent changes to abortion legislation may impact patient trust …