Digital Commons Network^™

Legislating For Humanity's Next Step: Cultivating A Legal Framework For The Mining Of Celestial Bodies, Joseph Crombie

Space and Defense

Rapid expansion in the space sector by state and private sector actors highlights the need for a new legal regulatory framework, particularly regarding property rights. The exploitation of space-based resources through the mining of asteroids is currently subject to a cold-war era international agreement that did not include clear consideration about how future off-world commercial exploitation might be regulated or property rights assigned. This article explores two empirical examples, the International Seabed Authority and the International Telecommunication Union, to determine whether they provide useful models of a future international legal framework for off-world property rights.

Modification Of Chitosan Using Glycidyl Methacrylate-Grafted Cellulose (Gmagcell/ Chi) For Methylene Blue Adsorption, Haya Fathana, Rahmi Rahmi, Muhammad Adlim, Surya Lubis

Karbala International Journal of Modern Science

In this study, a glycidyl methacrylate-grafted cellulose/chitosan (GMA-g-Cell/Chi) film was successfully prepared and characterized. GMA-g-Cell was obtained from the grafting process of cellulose derived from sugarcane bagasse using glycidyl methacrylate (GMA). The cellulose grafting process was obtained using 20% GMA for 4 hours at 60oC. The percentage of grafting (PG) and grafting efficiency (GE) values for these parameters were 516 and 60.28%, respectively. Chitosan was modified with GMA-g-Cell and has higher adsorption capacity and tensile strength than chitosan. The adsorption kinetics tend to follow the pseudo-first-order adsorption kinetics model, with Qe and k1 being 7 mg/g and 0.067 g/mg. minute. …

Summer Research Project Grow Depth Of Knowledge, Taylor University

2023 Website News Stories

No abstract provided.

Tak1 And Tbk1 Are Differentially Required By Gmp- And Lmpp-Like Leukemia Stem Cells, Austin P. Runde, Joseph Michael Cannova, Ryan Mack, Kanak Joshi, Mark Sellin, Allan Youmaran, Mattias Lenz, Rohit Thalla, Wei Wei, Peter Breslin S.J., Jiwang Zhang

School of Medicine

Acute myeloid leukemia (AML) encompasses a diverse group of cancers that originate in the blood-forming tissues of the bone marrow. Aside from the M3 subtype (PML-RARA⁺), AML carries a 5-year survival rate of 28% for patients 20+ years of age. AML is the most common cancer of the hematopoietic system and is slightly more common in biological males; the average age at diagnosis is 68 years. Standard frontline treatment for AML is a 2-phase regimen of intensive chemotherapy (CTx) employing daunorubicin and cytarabine. Despite 60-70% of patients achieving complete remission (CR), at least half of CR-achieving patients …

Greenhouse Gift To Help Ud Biology Students 'Get Their Hands Dirty', Cara Zinski-Neace

College of Arts and Sciences Newsroom

Ginny’s Garden and Greenhouse was dedicated in late September in honor of University of Dayton alumnus Virginia “Ginny” Ferron, who passed away in 2016.

2023 October 26 - Academic Council Agenda And Minutes, Academic Council, East Tennessee State University

Academic Council Agenda and Minutes

No abstract provided.

Shift Worker Patient & Family Advisor Council (Pfac), Grace Paniccia, Jonny Russell, Salma Habash, Philip Cheng

2023 Patient Advisor Retreat

The Shift Worker Patient and Family Advisory Council (SHIFT PFAC) is an active patient engagement program aimed at improving the lives of night shift workers through their involvement and influence in our studies. We are proud to work with night shift workers as they are a group often overlooked in healthcare initiatives. We aim to work with the SHIFT PFAC to improve not only the physical health, but also the job satisfaction and overall well-being of night shift workers. The purpose of the SHIFT PFAC meetings is to foster an open dialogue where study participants can share their valuable insights, …

Investigating The Use Of Utility Monitoring As A Means Of Recognizing Activities Of Daily Living To Enable Independent Living Among People Living With Dementia, Ciaran Nugent, Damon Berry, Jonathan Turner, Micheal Wilson, Ann Marron, Julie Doyle, Dympna O'Sullivan

Conference papers

No abstract provided.

Labile Dissolved Nickel (Ni) Concentrations In The North Pacific, Calyn M. Crawford

USF Tampa Graduate Theses and Dissertations

Nickel (Ni) is an important micronutrient for phytoplankton and bacteria that serves as a required co-factor in several metalloenzymes. Despite these known biological uses, total dissolved Ni concentrations remain elevated in global surface waters, in contrast to the surface depletion commonly observed for macronutrients and other nutrient-type trace elements. A prevailing hypothesis for the muted depletion of dissolved Ni concentrations in surface waters is that dissolved Ni in seawater is not in a bioavailable form. The chemical lability of Ni in seawater provides insight into Ni speciation and bioavailability, but few measurements have been made in the open ocean to …

Planning For The Lake Izabal Basin Research Endeavor (Libre) Continental Scientific Drilling Project In Eastern Guatemala, Jonathan Obrist-Farner, Andreas Eckert, Peter M.J. Douglas, Liseth Perez, Alex Correa-Metrio, Bronwen L. Konecky, Thorsten Bauersachs, Susan Zimmerman, Stephanie Scheidt, Mark Brenner, Steffen Kutterolf, Jeremy Maurer, Omar Flores, Caroline M. Burberry

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

As Earth's atmospheric temperatures and human populations increase, more people are becoming vulnerable to natural and human-induced disasters. This is particularly true in Central America, where the growing human population is experiencing climate extremes (droughts and floods), and the region is susceptible to geological hazards, such as earthquakes and volcanic eruptions, and environmental deterioration in many forms (soil erosion, lake eutrophication, heavy metal contamination, etc.). Instrumental and historical data from the region are insufficient to understand and document past hazards, a necessary first step for mitigating future risks. Long, continuous, well-resolved geological records can, however, provide a window into past …

Physical Decline Rates: Men Versus Women, Ray C. Fair

Cowles Foundation Discussion Papers

This paper uses world records by age in running, swimming, and rowing to estimate a biological frontier of decline rates for both men and women. Decline rates are assumed to be linear in percent terms up to a certain age and then quadratic after that, where the transition age is estimated. For both men and women decline rates are smallest for rowing, followed by swimming and then running.

Decline rates for women are roughly the same as those for men for the short swimming events. They are slightly larger for the longer swimming events and for the rowing events. They …

Tripartite Motif Protein 6 Promotes Hepatocellular Carcinoma Progression Via Multiple Pathways, Yifeng Zhang, Lin Yuan, Shanshan Cui, Song Wu

Turkish Journal of Medical Sciences

Background/aim: Hepatocellular carcinoma (HCC) ranks among the most prevalent malignancies worldwide and the third leading cause of cancer-related death. The TRIM (tripartite motif-containing) protein family members had been reported to be involved in carcinogenesis and tumor progression. Here we aimed to explore the expression profile of TRIM6 in HCC and investigate its clinical significance as well as underlying mechanisms. Materials and methods: We retrospectively enrolled 138 HCC patients that underwent surgical resection in our hospital and tested protein expression level of TRIM6 through immunohistochemical staining. The correlation between TRIM6 and patients? characteristics was assessed by Chi-square test. Log-rank test and …

Clinical Characteristics And Predictors For Recurrence In Chronic Nonbacterial Osteomyelitis: A Retrospective Multicenter Analysis, Kadi̇r Ulu, Rana İşgüder, Şeri̇fe Gül Karadağ, Esra Bağlan, Gülşah Kavrul Kayaalp, Gülçi̇n Otar Yener, Kübra Öztürk, Hafi̇ze Emi̇ne Sönmez, Semanur Özdel, Ferhat Demi̇r, Balahan Makay, Şevket Erbi̇l Ünsal, Betül Sözeri̇, Nuray Aktay Ayaz, Mustafa Çakan

Turkish Journal of Medical Sciences

Background/aim: Chronic nonbacterial osteomyelitis (CNO) is a rare disease of unknown etiology and most commonly occurs during childhood or adolescence. The purpose of this study is to collect data on the clinical features, outcomes, and management of the disease and to identify the factors affecting recurrence. Materials and methods: This is a retrospective multicenter cross-sectional study of pediatric patients diagnosed with CNO. A total of 87 patients with a diagnosis of CNO followed for at least 6 months in 8 pediatric rheumatology centers across the country between January 2010 and December 2021 were included in this study. Results: The study …

Hsa-Circ-0006091 Modulates The Proliferation Of Hepatocellular Carcinoma Via The Mir-622/Ccnb1 Axis, Xiaofeng Zhao, Ling He

Turkish Journal of Medical Sciences

Background/aim: Hepatocellular carcinoma (HCC) is a common type of cancer. We hypothesize that circular RNA-0006091 (circ0006091) affects the progression of HCC. The study aims to investigate the effect of circ-0006091 in HCC cells. Materials and methods: The levels of circ-0006091, microRNA-622 (miR-622), and cyclin B1 (CCNB1) were assayed using qRT-PCR and western blotting. The metastasis of the HCC cells was measured with wound healing and transwell assays. The protein expression levels of MMP-2 and MMP-9 were assayed with western blotting. Dual-luciferase reporter and RNA-pulldown assays were used to determine the link between miR-622 and circ-0006091 or CCNB1. Mice-based tests were …

Adjustable Bone Plate: From Bench To Operating Room, Gazi̇ Huri̇, Erdi̇ Özdemi̇r, Ömer Sunkar Bi̇çer, Pinar Huri̇, Sai̇t Polat, Tuğçe Sapmaz, Mahmut Nedi̇m Doral

Turkish Journal of Medical Sciences

Background/aim: We have designed an adjustable bone plate (ABP) which allows bone shortening and lengthening after fixation, which is a property not present in any of the plate systems available today. The aim of the current study was to examine the new ABP?s segmental bone transfer capability for the treatment of a segmental bone defect in an animal model. Materials and methods: Five sheep had ABPs attached to 10 of their tibias and bone defects of 15 mm in size were created. The pinion mechanism was moved with a manual screwdriver at a rate of 1mm/day for 15 days starting …

Recurrent Lower Urinary Tract Infections: More Than An Infection For Older Women, Sencer Gani̇dağli, Ercüment Öztürk, Zeynel Abi̇di̇n Öztürk

Turkish Journal of Medical Sciences

Background/aim: Older adults tend to have more urinary tract infections (UTIs). The frequency of recurrent lower urinary tract infections (rLUTIs) increases with age. rLUTIs are associated with long-term chronic effects on geriatric syndromes in older adults. We aimed to investigate possible risk factors that influence rLUTIs in older adults based on comprehensive geriatric assessment (CGA). Materials and methods: This cross-sectional study included 235 older adults admitted to Gaziantep University?s Geriatric Outpatient Clinic between June 1 and November 30, 2022. All patients underwent CGA. The Geriatric Depression Scale (GDS), the European Quality of Life-Five Dimension (EQ-5D) questionnaire, the Pittsburgh Sleep Quality …

The Importance Of Length And Area Estimate For Forensic Medicine Without Using A Measurement Tool, Ahmet Turla, Hüseyi̇n Kara, Ni̇lay Cankurt Ayar, Berna Aydin, Fulya Zeynep Levent, Oğuzhan Külbaz

Turkish Journal of Medical Sciences

Background/aim: Accurately measuring and recording the length or area of lesions affects the judgement of the forensic report, surgical wound management and, in some countries, the billing of health care services. The aim of this study was to determine whether the length and area of lesions described by physicians by estimation are accurate. Materials and methods: This study was designed as a cross-sectional descriptive study and was conducted with 494 participants consisting of internists and physicians at Ondokuz Mayıs University, Faculty of Medicine. The participants were asked to estimate the lengths or areas of 6 different shapes in the questionnaire …

The Sun Shines On Us, Too: Bobby Smith And Tampa's Early Lgbtq Community, Connor G. Lasseter

USF Tampa Graduate Theses and Dissertations

Bobby Smith (1923-2008) was a Tampa Bay butch lesbian, photographer, and earlyLGBTQ Florida figure, together with his partner of nearly fifty years, Katherine “Kay” Thompson (1923-2009). Coming of age as the Second World War provided women and girls with a certain level of independence, Smith easily found comfort presenting in a masculine, butch fashion outside of certain spheres such as school, and quickly dropped any remaining femininity once he left it. Throughout his life, in the workplace, at social gatherings, and at home, he maintained a masculine presentation for his entire life. As a photographer, Smith documented numerous photographs of …

Computational Investigations Of Polymer Electrolytes In Aqueous Solutions, Hishara Keshani Gallage Dona

LSU Doctoral Dissertations

Polymer electrolyte membranes, an intriguing category of soft materials, are characterized by polymer backbones tethered with negatively or positively charged functional groups, finding applications from biological macromolecules to electrochemical separations in fuel cells. This dissertation focuses on computational investigations of polymer electrolytes in aqueous solutions using polypeptoids and ion exchange membranes. Polypeptoids, highly tailorable peptidomimetic polymers lacking backbone hydrogen bonding or chirality, were used as model systems. Micelles formed from these polypeptoid polymers exhibited electrostatic repulsion, which competes with charge-sodium interactions, adding complexity to predicting micelle shapes. This research refined the design strategy, enhancing micelle shape and structure through precise …

Gardner-Webb Team Serves Children With Critical Illnesses And Their Families, Office Of University Communications

Gardner-Webb NewsCenter Archive

A team of 14 from Gardner-Webb University spent their fall break scooping ice cream, serving food, and giving hugs and high fives at Give Kids the World Village (GKTW) in Orlando, Fla. This 84-acre, non-profit resort serves children with a critical illness and their families. Everything is free—accommodations in fully-furnished villas, transportation, tickets to theme parks, meals, daily entertainment, and much more.

October 26, 2023, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Tigit Contributes To The Regulation Of 4-1bb And Does Not Define Nk Cell Dysfunction In Glioblastoma, Kyle B. Lupo, Sandra Torregrosa-Allen, Bennett D. Elzey, Sagar Utturkar, Nadia A. Lanman, Aaron A. Cohen-Gadol, Veronika Silvova, Mackenzie Mcintosh, Karen E. Pollok, Sandro Matosevic

Purdue University Libraries Open Access Publishing Fund

TIGIT is a receptor on human natural killer (NK) cells. Here, we report that TIGIT does not spontaneously induce inhibition of NK cells in glioblastoma (GBM), but rather acts as a decoy-like receptor, by usurping binding partners and regulating expression of NK activating ligands and receptors. Our data show that in GBM patients, one of the underpinnings of unresponsiveness to TIGIT blockade is that by targeting TIGIT, NK cells do not lose an inhibitory signal, but gains the potential for new interactions with other, shared, TIGIT ligands. Therefore, TIGIT does not define NK cell dysfunction in GBM. Further, in GBM, …

Serotonin Reduction In Post-Acute Sequelae Of Viral Infection, Andrea Wong, Ashwarya Devason, Iboro Umana, Timothy Cox, Lenka Dohnalová, Lev Litichevskiy, Jonathan Perla, Patrick Lundgren, Zienab Etwebi, Luke Izzo, Jihee Kim, Monika Tetlak, Hélène Descamps, Simone Park, Stephen Wisser, Aaron Mcknight, Ryan Pardy, Junwon Kim, Niklas Blank, Shaan Patel, Katharina Thum, Sydney Mason, Jean-Christophe Beltra, Michaël Michieletto, Shin Foong Ngiow, Brittany Miller, Megan Liou, Bhoomi Madhu, Oxana Dmitrieva-Posocco, Alex Huber, Peter Hewins, Christopher Petucci, Candice Chu, Gwen Baraniecki-Zwil, Leila Giron, Amy Baxter, Allison Greenplate, Charlotte Kearns, Kathleen Montone, Leslie Litzky, Michael Feldman, Jorge Henao-Mejia, Boris Striepen, Holly Ramage, Kellie Jurado, Kathryn Wellen, Una O'Doherty, Mohamed Abdel-Mohsen, Alan L Landay, Ali Keshavarzian, Timothy Henrich, Steven Deeks, Michael Peluso, Nuala Meyer, E. John Wherry, Benjamin Abramoff, Sara Cherry, Christoph Thaiss, Maayan Levy

Department of Microbiology and Immunology Faculty Papers

Post-acute sequelae of COVID-19 (PASC, "Long COVID") pose a significant global health challenge. The pathophysiology is unknown, and no effective treatments have been found to date. Several hypotheses have been formulated to explain the etiology of PASC, including viral persistence, chronic inflammation, hypercoagulability, and autonomic dysfunction. Here, we propose a mechanism that links all four hypotheses in a single pathway and provides actionable insights for therapeutic interventions. We find that PASC are associated with serotonin reduction. Viral infection and type I interferon-driven inflammation reduce serotonin through three mechanisms: diminished intestinal absorption of the serotonin precursor tryptophan; platelet hyperactivation and thrombocytopenia, …

Role Of Social Media In Adolescent-Parent Relationships Among At-Risk Youths, Jennifer Davis, Jessica L. Hart

Journal of Social, Behavioral, and Health Sciences

This study aimed to understand the role of adolescents’ and parents’ social media use in relation to adolescents’ reported at-risk behaviors, as well as the effect of social media on the relationships between at-risk youths and their parents. Semi-structured interviews, based on interpretive phenomenological analysis, were conducted with six pairs of individuals, 12 total participants. Each pair consisted of an adolescent between the ages of 13 and 17 and their parent. Data analysis resulted in three themes: Negativity they encountered on social media did not stop adolescents from using social media. Parental monitoring was problematized by parents’ lack of knowledge …

Investigating The Occurrence Of Blizzard Events Over The Contiguous United States Using Observations And Climate Projections, Ahmani Browne, Liang Chen

Department of Earth and Atmospheric Sciences: Faculty Publications

Over previous decades, the United States has been plagued by severe winter storms or blizzards, which caused millions of dollars in damages. However, the historical trend of blizzard events and the possible impacts of future global climate change on blizzard occurrences remain unclear. In this study, we analyzed historical blizzard occurrences using the observed storm event database, which shows that the Northern Plains, such as North Dakota, South Dakota, and Minnesota, had the most blizzard activities over the past 25 years. No significant trend in blizzard occurrence is found in those regions. When considering blizzards as compound events of strong …

Review Of Harmful Algal Bloom Effects On Birds With Implications For Avian Wildlife In The Chesapeake Bay Region, Barnett A. Rattner, Catherine E. Wazniak, Julia S. Lankton, Peter C. Mcgowan, Serguei V. Drovetski, Todd A. Egerton

United States Geological Survey: Staff Publications

The Chesapeake Bay, along the mid-Atlantic coast of North America, is the largest estuary in the United States and provides critical habitat for wildlife. In contrast to point and non-point source release of pesticides, metals, and industrial, personal care and household use chemicals on biota in this watershed, there has only been scant attention to potential exposure and effects of algal toxins on wildlife in the Chesapeake Bay region. As background, we first review the scientific literature on algal toxins and harmful algal bloom (HAB) events in various regions of the world that principally affected birds, and to a lesser …

Dietary Habits, Meal Timing, And Meal Frequency In Kuwaiti Adults: Analysis Of The Kuwait National Nutrition Surveillance Data, Fatema Alkhulaifi, Suad Al-Hooti, Sameer Al-Zenki, Husam Alomirah, Charles Darkoh

Faculty, Staff and Student Publications

Dietary habits, including meal frequency, meal timing, and skipping meals, have been extensively studied due to their association with the development of noncommunicable diseases (NCDs). This study describes dietary habits, meal timing, frequency, skipping meals, and late-night eating in Kuwaiti adults. Kuwait National Nutrition Surveillance System data were utilized to reach the objectives of this study. The findings reveal that approximately 54% of the adults in Kuwait eat after 10 p.m., 29% skip breakfast, and 9.8% skip dinner. Furthermore, adults in Kuwait consume 4.4 meals per day on average. Women skip breakfast more often and have more extended night fasting …

Understanding The Unique Needs, Experiences And Strategies Used By Icu Nurses To Be Resilient During The Covid-19 Pandemic, Teenu Xavier

Dissertations

The COVID-19 pandemic presented numerous challenges for nurses working in intensive care units (ICUs), leading to a significant impact on their mental and psychological well-being. Despite these challenges, resilience is recognized as a protective factor for ICU nurses that can enhance the well-being of healthcare professionals and enable them to cope effectively with stressors and challenges. But there is a gap in the literature about the experiences, unique needs, and resilience strategies used by ICU nurses in the United States (U.S.).

The purpose of this dissertation research was to complete three interrelated projects in order to gain a better understanding …

Impacting T-Cell Fitness In Multiple Myeloma: Potential Roles For Selinexor And Xpo1 Inhibitors, Adam Binder, Christopher Walker, Tomer Mark, Muhamed Baljevic

Department of Medical Oncology Faculty Papers

Competent T-cells with sufficient levels of fitness combat cancer formation and progression. In multiple myeloma (MM), T-cell exhaustion is caused by several factors including tumor burden, constant immune activation due to chronic disease, age, nutritional status, and certain MM treatments such as alkylating agents and proteasome inhibitors. Many currently used therapies, including bispecific T-cell engagers, anti-CD38 antibodies, proteasome inhibitors, and CART-cells, directly or indirectly depend on the anti-cancer activity of T-cells. Reduced T-cell fitness not only diminishes immune defenses, increasing patient susceptibility to opportunistic infections, but can impact effectiveness MM therapy effectiveness, bringing into focus sequencing strategies that could modulate …

Time-Series Analysis Of Coral Reef And Reef-Fish Biodiversity In The Florida Keys National Marine Sanctuary, Cara L. Estes

USF Tampa Graduate Theses and Dissertations

The general decline in coral-reef ecosystem health throughout the Caribbean between the 1970’s and late 1990’s seems to have slowed down or stopped, with only slight decreases in coral reef cover observed in the 2000’s through 2019. The earlier decline can be attributed to many different local and regional stressors that have acted together, and include naturally occurring (hurricanes, diseases) and anthropogenic pressures (increased sedimentation, fishing). These ecosystems provide a range of services to people, including food and protection from storms, with an annual benefit of billions of dollars. This has driven a desire to better understand these ecosystems. The …