Digital Commons Network^™

“We Need To Figure Out Who We Are”: Reframing Manhood In An Online Discussion Forum, Tomas Sanjuan Jr.

USF Tampa Graduate Theses and Dissertations

In this thesis, I explore the potential of online communities in negotiating alternative forms of “doing” masculinity. I focus on the /r/bropill which is hosted on Reddit – home to thousands of active discussion forums called subreddits. I argue that the members of /r/bropill subreddit are attempting to redefine what it means to live your life not only as a man but as a “good man.” Using a purposive sample, I analyzed 24 discussions which totaled 1325 posts (n = 1325). I conducted a qualitative textual analysis of the original posts and comments inspired by grounded theory. My findings reveal …

Mediport Use As An Acceptable Standard For Car T Cell Infusion., Maya Eylon, Snehit Prabhu, Samuel John, Maxwell J M King, Dhruv Bhatt, Kevin J. Curran, Courtney Erickson, Nicole A. Karras, Christine L. Phillips, Prakash Satwani, Michelle Hermiston, Erica Southworth, Susanne H C Baumeister, Julie-An Talano, Margaret L. Macmillan, Jenna Rossoff, Challice L. Bonifant, Douglas Myers, Rayne H. Rouce, Keri Toner, Timothy A. Driscoll, Emmanuel Katsanis, Dana B. Salzberg, Deborah Schiff, Satiro N. De Oliveira, Christian M. Capitini, Holly L. Pacenta, Thomas Pfeiffer, Niketa C. Shah, Van Huynh, Jodi L. Skiles, Ellen Fraint, Kevin O. Mcnerney, Troy C. Quigg, Joerg Krueger, John A. Ligon, Vanessa A. Fabrizio, Christina Baggott, Theodore W. Laetsch, Liora M. Schultz

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Mediport use as a clinical option for the administration of chimeric antigen receptor T cell (CAR T cell) therapy in patients with B-cell malignancies has yet to be standardized. Concern for mediport dislodgement, cell infiltration, and ineffective therapy delivery to systemic circulation has resulted in variable practice with intravenous administration of CAR T cell therapy. With CAR T cell commercialization, it is important to establish practice standards for CAR T cell delivery. We conducted a study to establish usage patterns of mediports in the clinical setting and provide a standard of care recommendation for mediport use as an acceptable …

2023-October-27-Etsu Cuts Ribbon On Newly Renovated Sturgill Family Dental Hygiene Clinic.Pdf, University Marketing And Communication, East Tennessee State University

ETSU News

East Tennessee State University’s College of Clinical and Rehabilitative Health Sciences celebrated the naming and unveiling of the newly renovated Sturgill Family Dental Hygiene Clinic on Thursday, ushering in a new era for the university’s dental hygiene program, which was established more than a half-century ago.

The Sturgill Family Dental Hygiene Clinic is named for Drs. Jeremiah and Riley Sturgill, who own Sturgill Consulting, Sturgill Endodontics and Sturgill Orthodontics.

Jeremiah is a native of Big Stone Gap, Virginia, and owns dental practices in Johnson City and Norton, Virginia. He received degrees in biology and business administration from King …

Equifinality And The Key Role It Plays In Understanding The Future Of Leadership, Sam T. Hunter, Austin C. Doctor, Matthew Allen, Gina Scott Ligon

Reports, Projects, and Research

As organizations continue to increase in diversity across a range of demographic, value-based, and attitudinal variables, there can be a natural tension around differing styles and approaches to leading. We offer that these differences need not necessarily serve as a source of conflict if organizations are able to embrace the principle of equifinality. Equifinality, applied to leadership, represents the notion that there is more than one pathway to leading successfully. By focusing on equifinality as a core principle, stylistic differences can add to the fabric of organizational life rather than being a source of tension in it. We offer an …

Advances In Molecular Pathology, Diagnosis, And Treatment Of Amyotrophic Lateral Sclerosis., Hristelina Ilieva, Mithila Vullaganti, Justin Kwan

Farber Institute for Neuroscience Faculty Papers

Although the past two decades have produced exciting discoveries in the genetics and pathology of amyotrophic lateral sclerosis (ALS), progress in developing an effective therapy remains slow. This review summarizes the critical discoveries and outlines the advances in disease characterization, diagnosis, imaging, and biomarkers, along with the current status of approaches to ALS care and treatment. Additional knowledge of the factors driving disease progression and heterogeneity will hopefully soon transform the care for patients with ALS into an individualized, multi-prong approach able to prevent disease progression sufficiently to allow for a dignified life with limited disability.

Tom Dusbiber, Oral History Interview, 2023, Finn Vincent-Fix, Matt Jones

Oral Histories

Thomas Dusbiber attended the Roosevelt School from Kindergarten in 1954 until he graduated in 1966. In this interview, Tom recounts his time at Roosevelt, talking about the quality of the teachers, the struggles of high school athletics, and where the popular hangout spots were when he was in school. He also explores the legacy of the school, and the reasons why so many former students remember it so fondly.

The Diamond, October 27, 2023, Dordt University

Dordt Diamond

• Front Page: Defender Days Boasts a Full Lineup; The Lasting Legacy of Steve Holtrop; Conflict in the Middle East Evokes a Christian Response
• News: Fire Department Called for Food Mishaps; Students Sign Up for Campus Connect; A Guide to the Third GOP Debate; Hallelujah Party Offers Trick-or-Treat Alternative; The Case of the Campus Cats; Defender Way Construction Finished
• Feature: Shane Kramer - From Military to University; Professor Unny Nzioka: The New Face in the Business Department; Curry Craze Offers Multicultural Experience; A School House on Wheels; What Does it Mean to be a Housekeeper at Dordt?; Senior …

Neuroprotective Agents With Therapeutic Potential For Covid-19, César A Zaa, Clara Espitia, Karen L Reyes-Barrera, Zhiqiang An, Marco A Velasco-Velázquez

Faculty, Staff and Student Publications

COVID-19 patients can exhibit a wide range of clinical manifestations affecting various organs and systems. Neurological symptoms have been reported in COVID-19 patients, both during the acute phase of the illness and in cases of long-term COVID. Moderate symptoms include ageusia, anosmia, altered mental status, and cognitive impairment, and in more severe cases can manifest as ischemic cerebrovascular disease and encephalitis. In this narrative review, we delve into the reported neurological symptoms associated with COVID-19, as well as the underlying mechanisms contributing to them. These mechanisms include direct damage to neurons, inflammation, oxidative stress, and protein misfolding. We further investigate …

A Text Analytics Model For Agricultural Knowledge Discovery And Sustainable Food Production: A Case Study From Oklahoma Panhandle, Ali Bagheri, Saleh Taghvaeian, Dursun Delen

Department of Agricultural and Biological Systems Engineering: Faculty Publications

With recent increases in the use of social media in agricultural communities, many farmers are showing more and more interest in participating in social media and sharing different aspects of their profession with peers and policymakers. However, researchers have not explored this valuable data source well enough to help improve agribusiness decision-making. This study aims to investigate the potential capability and richness of social media for agricultural knowledge discovery, which can help monitor, detect, and predict critical agricultural events and activities and develop more sustainable food production and agricultural economy. This research utilizes text-mining tools and techniques to collect, process, …

To What Extent Do Physiological Tolerances Determine Elevational Range Limits Of Mammals?, Jay F. Storz, Graham R. Scott

School of Biological Sciences: Faculty Publications

A key question in biology concerns the extent to which distributional range limits of species are determined by intrinsic limits of physiological tolerance. Here, we use common-garden data for wild rodents to assess whether species with higher elevational range limits typically have higher thermogenic capacities in comparison to closely related lowland species. Among South American leaf-eared mice (genus Phyllotis), mean thermogenic performance is higher in species with higher elevational range limits, but there is little among-species variation in the magnitude of plasticity in this trait. In the North American rodent genus Peromyscus, highland deer mice (Peromyscus maniculatus …

A Computational Study On The Impact Of Anchoring Groups On The Optical And Electronic Properties Of Triphenylamine-Based Dyes For Dye-Sensitized Solar Cell Applications, Geradius Deogratias, Grace Kinunda

Tanzania Journal of Science

Anchoring groups are crucial for enhancing the performance of dye-sensitized solar cells (DSSCs). For instance, cyanoacrylic acid serves as the primary anchoring group in DSSC due to its crucial elements required for effective electron transport. However, it suffers from degradation. To address this limitation, this study proposes alternative cyano-based anchoring groups for sensitizers. Density functional theory (DFT) and time-dependent DFT were used to investigate the optical and electronic properties of the dyes. The studied dyes (excluding the dye containing OH group) displayed three absorption bands within the visible and NIR regions. Low-energy peaks ranged from 498 to 576 nm, corresponding …

Scientific Landscape On Phthalates Biodegradation Research: A Bibliometric And Scientometric Study, Sai Ngassa, Cyprian Mpinda, Kessy F. Kilulya, Rose Masalu

Tanzania Journal of Science

This study investigated the scientific landscape of research on phthalate esters biodegradation using the Web of Science database up to 2022. The collected data were analysed using bibliometric and scientometric tools. A total of 863 scholarly documents published between 1975 and 2022 in 266 journals were selected for analysis. The analysis revealed a growth rate of 6.9% in the research field, with an average document age of 10.8 years. The trend in phthalate biodegradation research showed a steady increase in citations until 1997, followed by a slight decrease until 2005, but experienced renewed interest in 2006 and significant growth in …

Multi-Tissue Epigenetic Analysis Identifies Distinct Associations Underlying Insulin Resistance And Alzheimer's Disease At Cpt1a Locus, Chloé Sarnowski, Tianxiao Huan, Yiyi Ma, Roby Joehanes, Alexa Beiser, Charles S Decarli, Nancy L Heard-Costa, Daniel Levy, Honghuang Lin, Ching-Ti Liu, Chunyu Liu, James B Meigs, Claudia L Satizabal, Jose C Florez, Marie-France Hivert, Josée Dupuis, Philip L De Jager, David A Bennett, Sudha Seshadri, Alanna C Morrison

Faculty, Staff and Student Publications

BACKGROUND: Insulin resistance (IR) is a major risk factor for Alzheimer's disease (AD) dementia. The mechanisms by which IR predisposes to AD are not well-understood. Epigenetic studies may help identify molecular signatures of IR associated with AD, thus improving our understanding of the biological and regulatory mechanisms linking IR and AD.

METHODS: We conducted an epigenome-wide association study of IR, quantified using the homeostatic model assessment of IR (HOMA-IR) and adjusted for body mass index, in 3,167 participants from the Framingham Heart Study (FHS) without type 2 diabetes at the time of blood draw used for methylation measurement. We identified …

Neuroendocrine Regulation Of Chemokine Receptor-Mediated Leukocyte Migration Via Heteromeric G Protein-Coupled Receptor Complexes, Garrett Enten

USF Tampa Graduate Theses and Dissertations

Neuroendocrine regulation of the innate immune system is a well-documentedphenomenon. The underlying mechanisms, however, are not well understood. Here we show that at least 20 members of the human chemokine receptor (CR) family heteromerize with one or more members of the α1-adrenergic receptor (AR) family and that all CRs, apart from CXCR1, heteromerize with arginine vasopressin receptor 1A (AVPR1A) in recombinant systems. These heteromeric complexes are detectable in human monocytes and the monocytic leukemia cell line THP-1. Though currently technical limitations prevent the direct visualization of endogenously expressed higher-order hetero-oligomeric receptor complexes, we provide evidence through functional analysis and proximity-based …

Cellulose Ester As Membranes For Controlled Release Fertilizer’S, Muhammed Salman Fajis

USF Tampa Graduate Theses and Dissertations

Growing environmental pollution and non-sustainable materials has escalated the need for research in sustainable practices for many areas including crop production and fertilization. The conventional coating for the controlled-release fertilizers (CRFs) is non-biodegradable. Hence, the development of novel biodegradable coatings for fertilizer prills has emerged as an important area of study. In this thesis, conducting synthesis and application of cellulose esters (biomass membrane) as an encapsulation for the controlled release fertilizers. Therefore, the coating would be effective for a controlled release of nutrients to the crops by sustaining nature. Here, synthesized biodegradable cellulose esters by 8 and 16-carbon fatty acids …

Affordances And Limitations Of Molecular Representations In General And Organic Chemistry, Ayesha Farheen

USF Tampa Graduate Theses and Dissertations

Molecular representations that show chemical bonding are ubiquitous in general and organic chemistry. These help in communicating chemistry concepts that are fundamental to understanding how and why molecules interact. The goal of this dissertation work is to offer an evidence-based report on the affordances and limitations of the variety of molecular representations by chemistry topic. The variety of representations investigated are chemical formula, Lewis dot structure, line-angle diagram, ball and stick, space filling, and electrostatic potential maps. Five studies were conducted with general and organic chemistry students and three key findings emerged. First, affordances and limitations of molecular representations are …

Red Mangrove (Rhizophora Mangle) Recruitment And Retention Dynamics On Eastern Oyster (Crassostrea Virginica) Reefs In A Subtropical Estuary, Noreen Selma Mathews

USF Tampa Graduate Theses and Dissertations

Mangroves are invading oyster reefs in areas no longer impacted by winter freezes and completely transforming them into mangrove islands. The mechanisms influencing the transition between these two habitat states remain unclear. Here, I test experimentally whether oyster reef (Crassostrea virginica) structure directly facilitates red mangrove (Rhizophora mangle) propagule capture via differences in propagule retention and successful mangrove establishment. In addition to oyster reef structure, I compared physical reef features of size, elevation, and wind-wave exposure to uncover whether these traits influenced mangrove retention. Recently- abscised red mangrove propagules were inserted onto 21 oyster reefs across 5 sites in Tampa …

Wastewater Treatment Using Encapsulated Chabazite In Polyvinyl Alcohol-Sodium Alginate Hydrogel Biofilm Carriers, Susieanna Nevada Persaud

USF Tampa Graduate Theses and Dissertations

Nitrogen discharge from wastewater is a global issue and with increased urbanization as well as industrialization, it has become even more essential to develop more efficient wastewater treatment systems. The dominant form of nitrogen in wastewater is ammonium. Biological oxidation of ammonium to nitrite and nitrate is the first step in biological nitrogen removal processes. If left untreated, nitrogen can cause toxicity to aquatic life, unsafe changes in water quality, and eutrophication.

Biofilm carriers can help to improve the efficiency of traditional activated sludge wastewater treatment systems by reducing operating costs and reducing hydraulic retention time. Biofilm carriers also promote …

Irf1 Regulates Self-Renewal And Stress Responsiveness To Support Hematopoietic Stem Cell Maintenance, Alexandra J S Rundberg Nilsson, Hongxu Xian, Shabnam Shalapour, Jörg Cammenga, Michael Karin

Faculty, Staff and Student Publications

Hematopoietic stem cells (HSCs) are tightly controlled to maintain a balance between blood cell production and self-renewal. While inflammation-related signaling is a critical regulator of HSC activity, the underlying mechanisms and the precise functions of specific factors under steady-state and stress conditions remain incompletely understood. We investigated the role of interferon regulatory factor 1 (IRF1), a transcription factor that is affected by multiple inflammatory stimuli, in HSC regulation. Our findings demonstrate that the loss of IRF1 from mouse HSCs significantly impairs self-renewal, increases stress-induced proliferation, and confers resistance to apoptosis. In addition, given the frequent abnormal expression of IRF1 in …

Antidiabetic Potential Of Vitex Mombassae Fruits Extract In Streptozotocin-Nicotinamide Induced Diabetic Wistar Rat Model, Mussa B. Mbegeze, Joan J.E. Munissi, Flora Stephano, Ramadhani S.O. Nondo, Stephen S. Nyandoro

Tanzania Journal of Science

Besides changes in life styles and improper dietary patterns, the rapidly increasing burden of diabetes mellitus type 2 is correlated with antidiabetic agents currently in clinical use, which are costly, less effective, and present undesirable side effects. Natural products from plants are promising alternative sources for developing more effective and cost friendly antidiabetic agents. This study therefore investigated the antidiabetic potential of Vitex mombassae fruits extract (VMFE) in streptozotocin-nicotinamide induced diabetic Wistar rat model. Oral acute toxicity test was conducted in male Wistar rat using up and down method by following OECD Guideline 423 (2002). No clinical signs of toxicity …

Activated Carbon Based On Borassus Aethiopum Shells, Hulls, Kernels And Fruits For Removal Of Phenol And 2-Chlorophenol From Water, Ndatiye W. Ndatiye, Lupituko L. Mkayula, Grace A. Kinunda

Tanzania Journal of Science

This study aimed at developing activated carbons from Borassus aethiopum shells (BaS), hulls (BaH), kernels (BaK) and fruits (BaF) for removing phenol (Ph) and 2-chlorophenol (2-CP) from aqueous solution. The preparation of the activated carbons involved carbonization of the starting materials at 500 ºC followed by chemical activation at 600 ºC using 0.5 M H3PO4 acid. The prepared activated carbons were found to be mesoporous having pore sizes and surface areas in the range of 3.2 to 3.5 nm and 644 to 740 m2/g, respectively. Thermogravimetric analysis (TGA) thermograms showed that the prepared activated carbons can be applied in the …

Ecological Correlates For Endemic And Threatened Amphibians In The Uluguru Nature Forest Reserve, Tanzania, Joseph M. Christopher, Wilirk Ngalason, John V. Lyakurwa

Tanzania Journal of Science

Information on habitat characteristics for endemic and threatened amphibians along the altitudinal gradient in the Uluguru Nature Forest Reserve (UNFR) is limited. We assessed habitat characteristics associated with the occurrence of endemic and threatened amphibians in the Uluguru Nature Forest Reserve between April and June 2022. Bucket pitfall traps, time-constrained audio-visual surveys, plots and opportunistic searching were used to study amphibians in 6 sites along elevational gradient from 600 m to 2100 m a.s.l. Eighteen amphibian species were recorded, thirteen of them being endemic to the Eastern Arc Mountains, two near-endemic and three widely distributed. Among the species recorded, seven …

Phytochemical Constituents Of Cissus Oliveri Growing In Pwani Region, Tanzania, Fadhili S. Estomini, Stephen I. Nnungu, Amelia S. Buriyo

Tanzania Journal of Science

Cissus oliveri (Engl.) Gilg ex Engl. is among the plant species of the family Vitaceae widely used in traditional medicine for management of different ailments. This study aimed at assessing the phytochemicals of C. oliveri parts in order to provide scientific validation for its use as a therapeutic agent. Qualitative analysis of water and ethanolic extracts was conducted by using standard methods and the results revealed that all the parts possess alkaloids, flavonoids, phenols and tannins. Similarly, glycosides and saponins were only present in leaf and root. Quantitative analysis performed by gravimetric and spectrophotometric methods showed that all parts contain …

Habitat Use And Diet Composition Of The Common Eland (Tragelaphus Oryx) In Ngorongoro Conservation Area, Tanzania, Gregory A. Mtega, Cuthbert L. Nahonyo, Steven Temu, George Sangu, John Bukombe

Tanzania Journal of Science

Ngorongoro Conservation Area (NCA) is renowned worldwide for its multiple land use where pastoralism and wildlife conservation co-exist. Thus, the NCA must meet a delicate balance of competing needs between livestock and wildlife. Currently the NCA is  conducting resettlement program to facilitate pastoralists who are willing to move and resettle outside of the conservation area in order to reduce the number of people and livestocks in NCA. The common eland (Tragelaphus oryx) are among the large herbivore species found in the NCA that might be affected by possible competition between livestock and wildlife. The information on this species including habitat …

Association Of Residual Feed Intake To Metrics Of Tanganyika Shorthorn Zebu Cattle In Maswa And Misungwi Districts, Tanzania, Godfrey L. Chasama, Fred D. Chibwana, Aloyce S. Hepelwa, Jestina V. Katandukila

Tanzania Journal of Science

Increasing competition for feed resources and greenhouse gases pollution have been compelling beef production systems to operate at higher feed utilization. These challenges imply the need to breed cattle for Residual Feed Intake (RFI) to lower feeding costs and enteric methane production per output. To explore relevant indicator traits of RFI, this study investigated the association of RFI to Tanganyika Shorthorn Zebu (TSZ) cattle metrics from the Misungwi and Maswa Districts of Tanzania, where Tarime and Sukuma ecotypes are common. A correlation study involving the fattening of twenty-eight TSZ bulls was conducted at Tanzania Livestock Research Institute -Mabuki. From the …

Anticancer Potential Of The Leaf Extracts From The Selected Croton Species, Peter V. Fayyu, Joan J.E. Munissi, Stephen S. Nyandoro, Flora Stephano

Tanzania Journal of Science

The reported investigations were aimed at establishing anticancer potential of the leaf extracts from Croton dictyophlebodes (CDE), C. kilwae (CKE) and C. longipedicellatus ssp austrotanzanicus (CLE). In vitro cytotoxicity assays of the extracts were performed against human laryngeal cancer cell line (HEp-2) and human breast cancer cell line (MCF-7), while in vivo toxicological studies were done using Swiss albino mice (Mus musculus) following the Organization for Economic Cooperation and Development guideline number 423 of 2001. Results for in vitro assays revealed that CDE and CLE induced cytotoxicity to MCF-7 and HEp-2 cell lines at EC50 values of 86 and 63 …

Leucine Supplementation Exacerbates Morbidity In Male But Not Female Mice With Colorectal Cancer-Induced Cachexia, Eleanor R. Schrems, Wesley S. Haynie, Richard A. Perry Jr., Francielly Morena, Ana Regina Cabrera, Megan E. Rosa-Caldwell, Nicholas P. Greene, Tyrone A. Washington

Health, Human Performance and Recreation Faculty Publications and Presentations

Cancer cachexia (CC) is a multifactorial wasting syndrome characterized by a significant loss in lean and/or fat mass and represents a leading cause of mortality in cancer patients. Nutraceutical treatments have been proposed as a potential treatment strategy to mitigate cachexia-induced muscle wasting. However, contradictory findings warrant further investigation. The purpose of this study was to determine the effects of leucine supplementation on skeletal muscle in male and female Apc^Min/+ mice (APC). APC mice and their wild-type (WT) littermates were given normal drinking water or 1.5% leucine-supplemented water (n = 4–10/group/sex). We measured the gene expression of regulators of …

Coordination Between Aminoacylation And Editing To Protect Against Proteotoxicity, Hong Zhang, Parker Murphy, Jason Yu, Sukyeong Lee, Francis T F Tsai, Ambro Van Hoof, Jiqiang Ling

Faculty, Staff and Student Publications

Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes that ligate amino acids to tRNAs, and often require editing to ensure accurate protein synthesis. Recessive mutations in aaRSs cause various neurological disorders in humans, yet the underlying mechanism remains poorly understood. Pathogenic aaRS mutations frequently cause protein destabilization and aminoacylation deficiency. In this study, we report that combined aminoacylation and editing defects cause severe proteotoxicity. We show that the ths1-C268A mutation in yeast threonyl-tRNA synthetase (ThrRS) abolishes editing and causes heat sensitivity. Surprisingly, experimental evolution of the mutant results in intragenic mutations that restore heat resistance but not editing. ths1-C268A destabilizes ThrRS and …

The Spiritual Impact Of Disability On Parents And Caregivers, Grant Azbell

Discernment: Theology and the Practice of Ministry

This study was designed to examine the impact of disability on the faith and faith communities of parents and caregivers of persons experiencing disability. This study proceeded by asking nine parents or caregivers of persons experiencing disability a series of seven questions to evaluate the impact of disability on their faith and on their relationship to their faith community. The interviews were conducted on Zoom and the recordings were transcribed and coded to observe discernable patterns and themes amongst the participants. What emerged from the data is important for ministers, church leaders, and anyone wanting to know more about the …

Arms Control And Deterrence In The Age Of Cross-Domain Coercion, Damon Coletta

Space and Defense

For deterrence, now, first seek arms control. The old relationship linking deterrence, defense, and arms control served U.S. policy makers for decades during the Cold War. It was manifest through the Spirit of Geneva (1955) and the Reykjavik Summit (1986). Much later, during the rise of cross-domain coercion and following Russia’s annexation of Crimea, the same idea reemerged in NATO’s Warsaw Communique (2016).