Digital Commons Network^™

Isolation, Purification And Structure Analysis Of Polysaccharide From Lance Asiabell Root, Liu Yanqiu, Wang Yaru, Mao Dirui, Chang Kai

Food and Machinery

Objective: The structure of CLPS1 (polysaccharide fraction 1 of Codonopsis lanceolata) was determined to provide a basis for the study of polysaccharide activity of C. lanceolata and the development of natural plant polysaccharides. Methods: After extraction, separation, and purification, the separation component CLPS1 was determined by gas chromatography, infrared spectroscopy, nuclear magnetic resonance, periodate oxidation, Smith degradation, and methylation analysis to determine the structure of CLPS1. Results: The specific rotation of CLPS1 is +44°, the content of the total polysaccharide is 97.6%, the uronic acid of CLPS1 is 13.18%, and the molecular weight of CLPS1 is 91.7. The monosaccharide …

Ultrasound-Assisted Extraction And Antioxidant Study Of Crude Polysaccharide From Agrocybe Praecox, Han Xiaolei, Lu Huiying, Liang Jueqin, Fan Wei, Liu Tao, Huang Zhiqun, Yang Guoshun, Xiong Zhi

Food and Machinery

Objective: In order to explore the extraction method and antioxidant activity of crude polysaccharide from edible fungus resources of reed. Methods: The characteristic Agrocybe praecox of reed edible fungus of Dongting Lake District was used as raw material, the extraction rate of polysaccharide was used as the index, and the extraction was carried out by ultrasonic-assisted hot water alcohol precipitation method. After taking the liquid-material ratio, ultrasonic extraction time, ultrasonic extraction power, hot water extraction temperature, hot water extraction time as the factors to finish the single factor experiments. Then the experiments was optimized by Box-Behnken center combined experimental design …

Study On Optimizing Technology And Physicochemical Properties Of Coix Bran Dietary Fiber Prepared By Enzymatic Method, Lin Tinglong, Zou Lan, Pan Xiaowei, Liu Yuanjing

Food and Machinery

Objective: The study aimed to optimize the preparation process and investigate the quality of coix bran dietary fiber. Methods: The coix bran was used as raw material; the effects of solid-liquid ratio, the amount of amylase and alcalase on the extraction rate were analyzed by usingorthogonal experiments. The chemical composition and physicochemical properties of the dietary fiber obtained under the optimal preparation conditions was analyzed. Results: The optimal extraction parameters of dietary fiber were as follows: solid-liquid ratio was 1∶10 (g/mL), the amount of amylase and alcalase was 100 U/g, respectively, and the extraction rate was up to 84.39%. The …

Research Progress On Innovative Processing Technologies And Changes In Physicochemical Properties During The Pickling Of Pidan, Cheng Jing, Li Lichan, Wang Shaoyun, Yu Liyang, Yu Jie, Cai Xixi

Food and Machinery

In view of the limitations of the traditional processing technology of Pidan, this review summarizes the innovative processing technologies of Pidan, such as gradient temperature control, ultrasonic assisted, vacuum decompression, pulsating pressure, etc., and describes the changes of water, pH value, protein, free amino acids, texture, mineral elements and micro-morphology during the picking process of Pidan. Moreover, the development directions of Pidan products are prospected.

Functional Characteristics And Comprehensive Utilization Of Lonicerae Flos Resources, Liu Ping, Jia Fan, Hu Xiang, Xu Yao, Yang Yong

Food and Machinery

Lonicerae Flos is a Chinese medicinal material and medical-food homologous resource. It has a variety of pharmacological and health functions such as anti-oxidation, immune regulation, anti-inflammation and antibacterial. Based on the introduction of research process in the history of application, functional components and pharmacological activity of Lonicerae Flos resources, this review summarizes the current situation of comprehensive utilization of Lonicerae Flos and its by-product, and deeply discusses the comprehensive utilization of high-value of these resources from the perspectives of drugs, food, cosmetics, veterinary medicine feed and agricultural inputs. Finally, the comprehensive utilization of the Lonicerae Flos resources and the sustainable …

Research Progress On The Effect Of Whole Grain Components On Flour Product Qualities And Processing Characteristics, Shao Yulan, Sun Chenghang, Hu Bingbing

Food and Machinery

In this review, the effects of starch, protein, oil, polyphenols and other components in whole grains on the processing characteristics of dough and the quality of flour products were introduced, and problems and improvement measures of whole grain flour products were analyzed, in order to provide references for the research of whole grain flour products.

Research Progress On Constituent Structure And Extraction Technique Of The Polysaccharide From Agaricus Blazei, Cui Guomei, Liu Lina, Tian Guangrui, Li Shunfeng, Xu Fangfang, Wang Anjian

Food and Machinery

The composition, structure and functional properties of Agaricus blazei polysaccharide were summarized. The extraction techniques of polysaccharides and the features of different extraction methods were enumerated and compared. The problems in the research of A. blazei was discussed， such as unsystematic basic research, immature technological conditions, imperfect equipment and facilities, and low degree of specificity in seeds. In the end，the research direction of A. blazei polysaccharide was prospected.

Leading Online Professional Development For Instructional Technology Coaches With Effective Design Elements, Janet Cowart

Doctor of Education in Instructional Technology Dissertations

Online professional development became a necessity during the pandemic for educators, including Instructional Technology Coaches, to continue to gain knowledge to improve instruction. In this study, Instructional Technology Coaches participated in an online professional development series of synchronous and asynchronous sessions called Pathways. Two theoretical frameworks were used to support the research: Adult Learning Theory with an emphasis on the Theory of Computer-based Instruction for Adults, and TPACK. The seven characteristics of effective professional development created by Darling-Hammond et al. (2017) provided a foundation on which design elements to include in Pathways. There were 10 design elements that were implemented …

Stream Hydrology And A Pulse Subsidy Shape Patterns Of Fish Foraging, Kevin A. Fitzgerald, J. Ryan Bellmore, Jason Fellman, Matthew L. Cheng, Claire E. Delbecq, Jeffery A. Falke

Faculty, Staff, and Students

1. Pulsed subsidy events create ephemeral fluxes of hyper-abundant resources that can shape annual patterns of consumption and growth for recipient consumers. However, environmental conditions strongly affect local resource availability for much of the year, and can heavily impact consumer foraging and growth patterns prior to pulsed subsidy events. Thus, a consumer's capacity to exploit pulse subsidy resources may be influenced by antecedent environmental conditions, but this has rarely been shown in nature and is unknown in aquatic ecosystems. 2. Here, we sought to understand the importance of hydrologic variation and a salmon pulse subsidy on the foraging and growth …

Mcsa Forum Minutes 10/30/2023, Morris Campus Student Association

Morris Campus Student Association

No abstract provided.

Multichannel Low-Cost Sensor For Iaq Monitoring: Implementation And Guidelines, Isaac Ntiamoah

LSU Master's Theses

Indoor air quality (IAQ) is adversely affected by both indoor and outdoor environments, and rental homes occupied by low-income families suffer the most. Poor indoor air can be detrimental to the health of occupants, especially for susceptible populations like those with respiratory diseases such as asthma. Although IAQ monitoring is necessary, it is a challenging, costly, and time-intensive task. Moreover, the protocol for assessing IAQ in residential settings varies, and additional research is needed to establish a standard operating procedure that incorporates new monitoring technologies, such as low-cost air sensors. However, there is a dearth of comprehensive, evidence-based protocols for …

Invading Nonnative Frogs Use Different Microhabitats And Change Physiology Along An Elevation Gradient, Jack R. Marchetti, Susannah S. French, Emily E. Virgin, Erin L. Lewis, Kwanho C. Ki, Layne O. Sermersheim, George A. Brusch Iv, Karen H. Beard

Wildland Resources Faculty Publications

The coqui frog (Eleutherodactylus coqui) was introduced to the island of Hawai'i in the 1980s, and has spread across much of the island. There is concern they will invade higher elevation areas where negative impacts on native species are expected. It is not known if coqui change behavior and baseline physiology in ways that allow them to invade higher elevations. We investigated where coqui are found across the island and whether that includes recent invasion into higher elevations. We also investigated whether elevation is related to coqui's microhabitat use, including substrate use and height off the forest floor, …

Yeast Crf1p: An Activator In Need Is An Activator Indeed, Sanjay Kumar

LSU Doctoral Dissertations

Ribosome biogenesis is an energetically costly process, and tight regulation is required for stoichiometric balance between components. This requires coordination of RNA polymerases I, II, and III. Lack of nutrients or the presence of stress leads to downregulation of ribosome biogenesis, a process for which mechanistic target of rapamycin complex I (mTORC1) is key. mTORC1 activity is communicated by means of specific transcription factors, and in yeast, which is a primary model system in which transcriptional coordination has been delineated, transcription factors involved in regulation of ribosomal protein genes include Fhl1p and its cofactors, Ifh1p and Crf1p. Ifh1p is an …

Productivity Of Wood Ducks, Black-Bellied Whistling-Ducks, And Hooded Mergansers Using Nest Boxes In Louisiana, Dylan L. Bakner

LSU Doctoral Dissertations

Resident female wood ducks (Aix sponsa) in the southeastern United States are managed through nest box programs, with the goal of enhancing local hunting opportunities. Historically, hooded mergansers (Lophodytes cucullatus) were the only other cavity-nesting waterfowl species in the southeastern United States known to use these nest boxes. However, the recent northward range expansion of black-bellied whistling-ducks (Dendrocygna autumnalis) has extended into the range of wood ducks and mergansers. All three species are brood parasites, potentially using one another as hosts for their parasitic eggs and impacting their reproductive output. My research evaluated the …

Sigma1 Regulates Lipid Droplet-Mediated Redox Homeostasis Required For Prostate Cancer Proliferation, Halley Oyer, Alexandra Steck, Charles Longen, Sanjana Venkat, Konuralp Bayrak, Eleanor Munger, Dan Fu, Paola Castagnino, Christina Sanders, Nathalia Tancler, My Mai, Justin Myers, Matthew Schiewer, Nan Chen, Elahe Mostaghel, Felix Kim

Department of Urology Faculty Papers

UNLABELLED: Lipid droplets (LD) are dynamic organelles that serve as hubs of cellular metabolic processes. Emerging evidence shows that LDs also play a critical role in maintaining redox homeostasis and can mitigate lipid oxidative stress. In multiple cancers, including prostate cancer, LD accumulation is associated with cancer aggressiveness, therapy resistance, and poor clinical outcome. Prostate cancer arises as an androgen receptor (AR)-driven disease. Among its myriad roles, AR mediates the biosynthesis of LDs, induces autophagy, and modulates cellular oxidative stress in a tightly regulated cycle that promotes cell proliferation. The factors regulating the interplay of these metabolic processes downstream of …

Synthesis And Biological Assessment Of Alkyl Pyridine Antimicrobials, Juan Canchola

Theses and Dissertations

In previous work, my research group and I reported on the synthesis of Anaephenes A and B and confirmed their biological activities. We also found that these compounds were active against drug resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA). This finding lead to a series of structure activity relationship studies (SAR) to develop analogs with improved biological activities. Near the start of my graduate studies, my team and I reported an SAR where we generated eighteen analogs. Among the series of analogs, we made were a few that displayed high potency and shared a similar amphipathic structure. One of …

In Vivo Treatment With Insulin-Like Growth Factor 1 Reduces Ccr5 Expression On Vaccine-Induced Activated Cd4+ T-Cells, Massimiliano Bissa, Veronica Galli, Luca Schifanella, Monica Vaccari, Mohammad Arif Rahman, Giacomo Gorini, Nicolò Binello, Sarkis Sarkis, Anna Gutowska, Isabela Silva De Castro, Melvin N. Doster, Ramona Moles, Guido Ferrari, Xiaoying Shen, Georgia D. Tomaras, David C. Montefiori, Kombo F. N’Guessan, Dominic Paquin-Proulx, Pamela A. Kozlowski, David J. Venzon, Hyoyoung Choo-Wosoba, Matthew W. Breed, Joshua Kramer, Genoveffa Franchini

School of Graduate Studies Faculty Publications

At the heart of the DNA/ALVAC/gp120/alum vaccine’s efficacy in the absence of neutralizing antibodies is a delicate balance of pro- and anti-inflammatory immune responses that effectively decreases the risk of SIVmac251 acquisition in macaques. Vaccine efficacy is linked to antibodies recognizing the V2 helical conformation, DC-10 tolerogenic dendritic cells eliciting the clearance of apoptotic cells via efferocytosis, and CCR5 downregulation on vaccine-induced gut homing CD4+ cells. RAS activation is also linked to vaccine efficacy, which prompted the testing of IGF-1, a potent inducer of RAS activation with vaccination. We found that IGF-1 changed the hierarchy of V1/V2 epitope recognition and …

The Echo: October 30, 2023, Taylor University

2023-2024 (Volume 111)

No abstract provided.

Retrospective Review Of Coronavirus Vaccine Impact With Rheumatic Biologics, Alpana Bala Jayadevan

DNP and Student Works

Rheumatic illnesses are chronic diseases that cause the immune system to attack the bodies joints, muscles, bones, and organs (Mayo Clinic Health System, 2022). In many cases, rheumatic illnesses can cause severe disability and end organ damage leading to mortality if left untreated. Many rheumatological patients are on biologic disease modifying anti-rheumatic drugs (bDMARDs) and this has significantly improved the outcome for patients with rheumatic diseases (Humphreys et al., 2016). These medications work by suppressing the immune system to control inflammation and bDMARDs have significantly improved the quality of life of individuals with rheumatological conditions. Unfortunately, patients who are on …

Studying On The Hypoglycemic Activity Of Green Tea Polyphenols From Camellia Ptilophylla Chang Using High-Resolution Mass Spectrometry And Network Pharmacology, Huang Qiuyan, Li Bin, Lin Xiaorong, Lu Sen, Chen Zhongzheng, Zhang Yuanyuan

Food and Machinery

Objective: This study aimed to explore the composition and the functional bioactivity of tea polyphenols from cocoa tea. Methods: Chemical components of crude green tea polyphenol extracts from cocoa tea were analyzed and identified using high resolution mass spectrometry. Additionally, their potential functional effects were predicted by network pharmacological analysis. Results: The in vitro hyperglycemic potential of crude green tea polyphenol from cocoa tea was preliminarily confirmed based on their strong inhibition on α-glucosidase and α-amylase. Six key targets including GAPDH and AKT and multiple pathways such as PI3K-AKT were predicted to be involved in the underying mechanisms behind the …

Tomato Surface Defect Detection Method Based On Image Local Variance Considering Brightness Correction, He Tingting, Yao Jichao, Zhang Zhonglili, Lu Tiangang, Yue Huanfang

Food and Machinery

Objective: In order to solve the problem of inaccurate defect extraction caused by complex and variable color and irregular texture changes of tomato surface defects, the defect segmentation method based on image local variance with brightness correction was proposed. Methods: On the basis of using histogram threshold segmentation method to segment calyx and stem scar and the method of domain pixel weighted sum to replace the original pixel to complete the brightness correction, the gray image of tomato surface was divided into several image blocks, and the color of each block was characterized by image pixel variance, and then the …

Suicidal Ideation And Community Connectedness In Lgbtq+ Adults: Can Emotion Regulation And Mindfulness Skills Help?, Samantha V. Jacobson

Clinical Psychology Dissertations

Suicidal ideation disproportionally affects the LGBTQ+ community. Community connectedness and mindfulness can be protective against suicidal ideation, whereas emotion regulation difficulty is associated with increased suicidal ideation. Community connectedness, emotion regulation difficulty and mindfulness have demonstrated relationships to each other in the LGBTQ+ community and while they are each independently associated with suicidal ideation, their combined impact on suicidal ideation has not yet been examined. The present study examines moderating effects of emotion regulation difficulty and mindfulness on the relationship between community connectedness and suicidal ideation in LGBTQ+ adults. 141 LGBTQ+ adults completed self-report measures of suicidal ideation, community connectedness, …

Changes In Lipid Profiles Of Epileptic Mouse Model, Alicia Johnson, Ryan A. Grove, Deepak Madhavan, Cory Honsinger Thomas Boone, Camila Pereira Braga, Hannah Kyllo, Kaeli Samson, Timothy Simeone, Tomáš Helikar, Corrine K. Hanson, Jiri Adamec

Department of Biochemistry: Faculty Publications

Introduction—Approximately 1% of the world’s population is impacted by epilepsy, a chronic neurological disorder characterized by seizures. One-third of epileptic patients are resistant to AEDs, or have medically refractory epilepsy (MRE). One non-invasive treatment that exists for MRE includes the ketogenic diet, a high-fat, low-carbohydrate diet. Despite the KD’s success in seizure attenuation, it has a few risks and its mechanisms remain poorly understood. The KD has been shown to improve metabolism and mitochondrial function in epileptic phenotypes. Potassium channels have implications in epileptic conditions as they have dual roles as metabolic sensors and control neuronal excitation.

Objectives—The …

Mga-Seq: Robust Identification Of Extrachromosomal Dna And Genetic Variants Using Multiple Genetic Abnormality Sequencing, Da Lin, Yanyan Zou, Xinyu Li, Jinyue Wang, Qin Xiao, Xiaochen Gao, Fei Lin, Ningyuan Zhang, Ming Jiao, Yu Guo, Zhaowei Teng, Shiyi Li, Yongchang Wei, Fuling Zhou, Rong Yin, Siheng Zhang, Lingyu Xing, Weize Xu, Xiaofeng Wu, Bing Yang, Ke Xiao, Chengchao Wu, Yingfeng Tao, Xiaoqing Yang, Jing Zhang, Sheng Hu, Shuang Dong, Xiaoyu Li, Shengwei Ye, Zhidan Hong, Yihang Pan, Yuqin Yang, Haixiang Sun, Gang Cao

Children’s Nutrition Research Center Staff Publications

Genomic abnormalities are strongly associated with cancer and infertility. In this study, we develop a simple and efficient method - multiple genetic abnormality sequencing (MGA-Seq) - to simultaneously detect structural variation, copy number variation, single-nucleotide polymorphism, homogeneously staining regions, and extrachromosomal DNA (ecDNA) from a single tube. MGA-Seq directly sequences proximity-ligated genomic fragments, yielding a dataset with concurrent genome three-dimensional and whole-genome sequencing information, enabling approximate localization of genomic structural variations and facilitating breakpoint identification. Additionally, by utilizing MGA-Seq, we map focal amplification and oncogene coamplification, thus facilitating the exploration of ecDNA's transcriptional regulatory function.

Jak3 Inhibition Regulates Stemness And Thereby Controls Glioblastoma Pathogenesis, William Smedley, Amiya Patra

Peninsula Medical School

Glioblastoma multiforme (GBM) is the most deadly brain tumor, effective treatment options for which still remain elusive. The current treatment procedure of maximal resection followed by chemotherapy has proved to be grossly insufficient to prevent disease progression and death. Despite best efforts, the maximum survival post-diagnosis is a mere 1.5 years. Therefore, there is a huge unmet clinical need to find effective therapeutic procedures to prevent the pathogenesis and relapse of GBM. Small-molecule inhibitors of signaling pathways are an attractive option to prevent various types of tumors. However, no effective small-molecule inhibitors have been successful against GBM in clinical trials. …

Recent Advances In The Synthesis And Antioxidant Activity Of Low Molecular Mass Organoselenium Molecules, João M Anghinoni, Paloma T Birmann, Marcia J Da Rocha, Caroline S Gomes, Michael J Davies, César A Brüning, Lucielli Savegnago, Eder J Lenardão

Faculty, Staff and Student Publications

Selenium is an essential trace element in living organisms, and is present in selenoenzymes with antioxidant activity, like glutathione peroxidase (GPx) and thioredoxin reductase (TrxR). The search for small selenium-containing molecules that mimic selenoenzymes is a strong field of research in organic and medicinal chemistry. In this review, we review the synthesis and bioassays of new and known organoselenium compounds with antioxidant activity, covering the last five years. A detailed description of the synthetic procedures and the performed in vitro and in vivo bioassays is presented, highlighting the most active compounds in each series.

Executive Order On The Safe, Secure, And Trustworthy Development And Use Of Artificial Intelligence, Joseph R. Biden

Copyright, Fair Use, Scholarly Communication, etc.

Section 1. Purpose. Artificial intelligence (AI) holds extraordinary potential for both promise and peril. Responsible AI use has the potential to help solve urgent challenges while making our world more prosperous, productive, innovative, and secure. At the same time, irresponsible use could exacerbate societal harms such as fraud, discrimination, bias, and disinformation; displace and disempower workers; stifle competition; and pose risks to national security. Harnessing AI for good and realizing its myriad benefits requires mitigating its substantial risks. This endeavor demands a society-wide effort that includes government, the private sector, academia, and civil society.

My Administration places the highest urgency …

The Rider (2023-10-30), Natalie Lapsley

The Rider Archives

Vol.9 No.10

Peer Influence As The Dominant Factor In Coffee Drink Consumption Among Non-Health Major University Of Indonesia Students In 2023, Patrisha Ramadhiani, Triyanti Triyanti, Sandra Fikawati

Indonesian Journal of Public Health Nutrition (IJPHN)

Coffee drinks are sugar-sweetened beverages made from coffee powder, sugar, and water through heating. High consumption of coffee drinks is associated with sugar content, which can increase the risk of obesity. The aim of this study was to determine the differences in coffee drink consumption levels based on individual characteristics and environmental factors among non-health undergraduate students at the University of Indonesia in 2023. This quantitative study used a cross-sectional design with a sample of 181 active undergraduate non-health students in 2023. Data were collected in June 2023 through a self-administered questionnaire. The results showed that 52.5% of the respondents …

The Difference Of Ultra-Processed Food Consumption Based On Individual Characteristics And Other Factors Among Non-Health Undergraduate Students In Universitas Indonesia In 2023, Adeline Vashtianada, Asih Setiarini, Ratu Ayu Dewi Sartika

Indonesian Journal of Public Health Nutrition (IJPHN)

Ultra-processed food/UPF is a product that undergoes a series of industrial techniques and processes, also has low nutritional value. Overconsumption of UPF can increase the risk of overweight and obesity. The purpose of this study is to determine the differences in the proportion of UPF consumption based on individual characteristics, environmental factors, and lifestyle factors among non-health undergraduate students in Universitas Indonesia in 2023. A cross sectional study design conducted on 149 samples. The data was collected using a self-administered online questionnaire. The data was analyzed using univariate and bivariate (chi-square) analyses. The results showed that 50.3% of the students …