Digital Commons Network^™

Precipitation And Greenness In Pastoral Lands Of East Turkana, Kenya, Paul Akpejeluh

School of Natural Resources: Dissertations, Theses, and Student Research

Pastoralism has long supported livelihoods and provided essential ecosystem services in landscapes of East Africa. Vegetation productivity is central to the functioning of pastoral systems but may be affected by changes in climate and landuse. Vegetation monitoring is important for understanding the effects of global change in pastoral lands; however, it can be time and resource intensive. Remote sensing provides opportunities for efficient multi-scale monitoring of vegetation and climatic drivers. In this thesis, I explore the utility of satellite and UAV remote sensing for monitoring vegetation and precipitation trends and relationships in the East of Lake Turkana Region of northern …

Connecting The Nebraska Water Quality Index To The Aquatic Microbial Community Of The North Platte River Basin, Nebraska, Paula R. Guastello

School of Natural Resources: Dissertations, Theses, and Student Research

The Nebraska Water Quality Index, under development by the Nebraska Department of Environment and Energy, summarizes in a single value eight environmental parameters that have been monitored in Nebraska for nearly 20 years. Water quality parameters including those used in the Nebraska Water Quality Index have been shown in previous studies to impact bacterial growth. As such, this index has the potential to correlate with the freshwater microbial community. Here, I relate the Nebraska Water Quality Index to microbial community composition and structure using 16S rRNA gene amplicon sequence data collected from the North Platte River Basin, Nebraska. This index …

The Role Of Glacier Erosion In Riverine Particulate Organic Carbon Export, Megan Behnke, Jason B. Fellman, Sonia Nagorski, Robert G. Spencer, Eran Hood

Faculty, Staff, and Students

Biospheric particulate organic carbon (POCbio) burial and rock petrogenic particulate organic carbon (POCpetro) oxidation are opposing long-term controls on the global carbon cycle, sequestering and releasing carbon, respectively. Here, we examine how watershed glacierization impacts the POC source by assessing the concentration and isotopic composition (δ13C and Δ14C) of POC exported from four watersheds with 0%–49% glacier coverage across a melt season in Southeast Alaska. We used two mixing models (age-weight percent and dual carbon isotope) to calculate concentrations of POCbio and POCpetro within the bulk POC pool. The fraction POCpetro contribution was highest in the heavily glacierized watershed (age-weight …

Data File: Oak Seedling (Quercus Macrocarpa) Survivorship And Condition After Two Growing Seasons, Lindsey Dewey, Michaela Woods, Madelaine Gregory, Ryan W. Mcewan

Data Files: Ecosystem Restoration Following Industrial Agriculture

This spreadsheet is the height, basal diameter, stem weight, root weight, total weight, survivorship, and presence of herbivory on Burr Oak seedlings after two growing seasons in the Spring Run experimental restoration site (39° 46 '42.2"N, 84° 20' 52.5"W).

DOI: https://doi.org/10.26890/trp9652

The Federal Circuit’S Experimental Prism, Jeremy W. Bock

Fordham Law Review

Whether the U.S. Court of Appeals for the Federal Circuit is succeeding in its role as the steward of decisional patent law has been the subject of considerable debate and many empirical studies for the past forty years. Based on these studies, some observers have expressed skepticism of the utility of that court’s exclusive, nationwide jurisdiction over patent appeals. But the substantial body of empirical literature on the Federal Circuit has been viewed largely from a single vantage point, one that attributes any negative or undesirable outcomes to the court’s specialization. This Article argues that there is another way to …

Yellowtail Snapper, Abigayle Groth, David Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

Deficient Aeronautical Decision-Making Contributions To Fatal General Aviation Accidents, Douglas D. Boyd, Mark Scharf Phd

Publications

INTRODUCTION: General aviation (GA), mainly comprised of light (≤12,500 lb) aircraft, maintains an inferior safety record compared with air carriers. To improve safety, aeronautical decision-making (ADM) practices have been advocated to GA pilots since 1991. Herein, we determined the extent to which GA pilots disregard such practices. METHODS: Fatal accidents (1991–2019) involving private pilots (PPLs) in single-engine airplanes were identified (N = 1481) from the National Transportation Safety Board AccessR database. Of these, deficient go/no-go and in-flight ADM-related mishaps were scored using the PAVE (pilot, aircraft, environment, external pressure)/IMSAFE (illness, medicine, stress, alcohol, fatigue, eating) and PPP (perceive, process, …

Interactive Effects Of Increased Nestbox Temperature And Vitamin E On Nestling Growth Are Attenuated By Plasticity In Female Incubation Effort, Paige A. Duncan, Ashley M. Tauber, Scott K. Sakaluk, Charles F. Thompson

Faculty Publications – Biological Sciences

In recent years, temperatures have increased globally, and nestlings of many bird species are likely regularly exposed to increased temperatures both pre- and post-natally. Even small increases in nest temperature during incubation affect offspring growth and survival in a variety of species, one cause of which is thought to be increased production of pro-oxidants in embryos and nestlings. Defences marshalled in response to this oxidative stress could, in turn, result in trade-offs that lead to reduced survival or growth. If so, any downstream negative effects on nestlings of increased ambient temperatures during incubation could be counteracted by increasing their antioxidant …

Tracing Evolution Of Gene Transfer Agents Using Comparative Genomics, Roman Kogay

Dartmouth College Ph.D Dissertations

The accumulating evidence suggest that viruses and their components can be domesticated by their hosts, equipping them with convenient molecular toolkits for various functions. One of such domesticated system is Gene Transfer Agents (GTAs) that are produced by some bacteria and archaea. GTAs morphologically resemble small phage-like particles and contain random fragments of their host genome. They are produced only by a small fraction of the microbial population and are released through a lysis of the host cell. Bioinformatic analyses suggest that GTAs are especially abundant in the taxonomic class of Alphaproteobacteria, where they are vertically inherited and evolve …

Design Guidance For Wetland-Road Crossings To Reduce Blanding’S Turtle Mortality Risk, Thomas P. Ballestero, Lauren E. White, Sandra Houghton, David Burdick, Josh Megyesy

Faculty Publications

Road mortality is a leading threat to freshwater turtles, particularly the Blanding’s turtle (Emydoidea blandingii), an endangered species in New Hampshire. Wildlife wetland-crossing structures, such as culverts and/or fences, have proven effective in reducing wildlife road mortality while retaining habitat connectivity. Funding for adequate wetland-crossing creation or restoration is limited, so prioritizing areas of high mortality risk is essential to ensuring that the resources spent are impactful. A research team of professionals from the New Hampshire Department of Environmental Services, New Hampshire Fish and Game, University of New Hampshire, and other organizations formed to create a model capable …

Using Biometrics, Behavioral Observations, And Multiple Molecular Techniques To Assess The Impacts Of Changes In Temperature And Salinity On The Common Bay Mussel (Mytilus Trossulus), Casey Martin

Dissertations and Theses

The intertidal zone is a place of rapid and frequent change that is home to a variety of creatures who are essential to the integrity of the habitat. Mussels are robust sessile bivalves that anchor to the rocks of the intertidal. The prominent species on the Oregon Coast, the Common Bay Mussel (Mytilus trossulus), plays an essential role as a coastal food source, water column filter, and barrier to prevent erosion due to wave action. Mytilus trossulus withstands daily shifts in temperature, salinity, and tide, as well as seasonal changes. Global climate change due to excess carbon emissions …

Antitumor Activity Of Carboxymethyl Pachymaran With Different Molecular Weights Based On Immunomodulatory And Gut Microbiota, Yalin Zhao, Xi Feng, Lijia Zhang, Wen Huang, Ying Liu

Faculty Research, Scholarly, and Creative Activity

Carboxymethyl pachymaran (CMP) was treated via high-temperature and cellulase hydrolysis to obtain HTCMP, HTEC-24, and HTEC-48. The chemical structure and in vivo antitumor activities of the four types of CMPs were investigated. Compared with CMP (787.9 kDa), the molecular weights of HTCMP, HTEC-24, and HTEC-48 were decreased to 429.8, 129.9, and 68.6 kDa, respectively. The viscosities and particle sizes of the CMPs could also decrease with the decline in the molecular weights. All the CMPs showed antitumor abilities, but HTEC-24 exhibited the best activity. In the animal study, when curing the spleen and thymus, CMPs displayed immunomodulatory effects by increasing …

Shedding Light On Cellular Glycolysis Pathway Kinetics: Combining Kinetic, Mechanistic Modelling Approaches With Label Free Microspectroscopic Imaging. (Cytomechspec), Nitin Patil

Articles

Glycolysis pathway kinetics in cells are known to be modulated for several disorders (cancers, neurodegenerative disorders, diabetes, etc.) and are currently been targeted as a biomarker for disease diagnostics and therapy. Although there are several approaches for monitoring the pathway kinetics, ranging from simple kinetic biochemical assays to sophisticated omics techniques, there remains a significant gap in the field, as there is a noticeable compromise between the extent of insights achievable from approaches which are destructive to the sample, and the real-time, kinetic analysis of a system.

Vibrational spectroscopy is a powerful, label-free, non-invasive tool capable of sub-cellular resolution, the …

A Descriptive Study Of Louisiana 4-H 8th Through 12th Graders' Perceptions Of Career And College Readiness, Carrie M. Lane

LSU Master's Theses

As youth leave primary education and enter college or a career path, preparing those youth to ensure success has fallen, in large part, upon formal and non-formal youth educators. Encouraging students to apply and complete college has been a focus of education professionals for many years. Historically, gauging college and career readiness (CCR), academic institutions have relied on academic performance in areas of English Language Arts and Mathematics (Mattern, et. al, 2014). The use of academic focused measures instead of student-based evaluation had its drawbacks. While core education is important, measuring soft skills needed for the workforce and college environment …

Characterizing How Food Advertising And Genetic Obesity Risk Factors Affect Neural Reward Reactivity And Eating In The Absence Of Hunger In Children, Dabin Yeum

Dartmouth College Ph.D Dissertations

The complex and multifactorial etiology of obesity involves the interaction of numerous risk factors. Assessing the gene-environment interaction of pediatric obesity can provide valuable insights for the characterization of key factors contributing to obesity and identification of potential points of intervention. The data used in this thesis comes from a single sample of young children recruited from the communities surrounding Dartmouth College. The primary objective of this thesis is to assess the impacts of complicated gene-environment interaction on pediatric obesity. First, we assessed the dynamic and static advertising of food cues to examine they lead to differential neural reward responsivity. …

University Of Arkansas, Chemistry And Biochemistry Department Graduate Student Publications, 2018- November 2023. 39p., Jeremy Smith, Lutishoor Salisbury

University Libraries Faculty Publications and Presentations

This report provides a compilation of the research publications by the Chemistry and Biochemistry (CHBC) Graduate students for the period: 2018-November 2023. It includes publications by the CHBC graduates and those where a CHBC faculty was the main advisor. It includes a summary of the research. The listing is organized according to type of publications within specific years.

University Of Arkansas, Chemistry And Biochemistry Department Research Publications, 2014- November 2023. 107p., Jeremy Smith, Lutishoor Salisbury

University Libraries Faculty Publications and Presentations

This report provides a compilation of the research publications by the Chemistry and Biochemistry faculty for the period: 2014 - November 2023. The information was gathered from major databases in science and technology including Web of Science, SciFinder, Reaxys, PubMed, IEEE Explore and Engineering Index. At least one author in each of the publications has the CHBC department as its affiliation. It includes a table summarizing the research. The listing is organized according to type of publications within specific years.

Materials Characterization: Can Artificial Intelligence Be Used To Address Reproducibility Challenges?, Miu Lun Lau, Abraham Burleigh, Jeff Terry, Min Long

Computer Science Faculty Publications and Presentations

Material characterization techniques are widely used to characterize the physical and chemical properties of materials at the nanoscale and, thus, play central roles in material scientific discoveries. However, the large and complex datasets generated by these techniques often require significant human effort to interpret and extract meaningful physicochemical insights. Artificial intelligence (AI) techniques such as machine learning (ML) have the potential to improve the efficiency and accuracy of surface analysis by automating data analysis and interpretation. In this perspective paper, we review the current role of AI in surface analysis and discuss its future potential to accelerate discoveries in surface …

Wrack Lines Volume 23, No. 2, Fall-Winter 2023-2024, Syma A. Ebbin, Ralph Lewis, Judy Benson, Diana Payne, Miriah Russo Kelly

Wrack Lines

Learn about the inspiring journey of a mini sailboat, lessons from beaches and school aquariums and the unique geology of the Connecticut shoreline in the Fall-Winter 2023-2024 issue of Wrack Lines magazine. More good reading can be found in articles about how the ocean literacy campaign and ocean identity research are working to expand marine science education.

Titled, “Learning about the Sea: How it Becomes Real, Visible and Connecticut to Human Life,” the issue presents the diverse and exciting realm of marine science education, from international excursions to the geologic stories of our coast; from classrooms and beach field trips …

The Effects Of Ethanol Preservation On High-Molecular Weight Dna, Maia Jackson

Honors Capstones

No abstract provided.

Α-Synuclein Is The Major Platelet Isoform But Is Dispensable For Activation, Secretion, And Thrombosis, Alexis N. Smith, Smita Joshi, Harry Chanzu, Hammodah Rawhi Hammodah Alfar, Kanakanagavalli Shravani Prakhya, Sidney W. Whiteheart

Saha Cardiovascular Research Center Faculty Publications

Platelets play many roles in the vasculature ensuring proper hemostasis and maintaining integrity. These roles are facilitated, in part, by cargo molecules released from platelet granules via Soluble NSF Attachment Protein Receptor (SNARE) mediated membrane fusion, which is controlled by several protein-protein interactions. Chaperones have been characterized for t-SNAREs (i.e. Munc18b for Syntaxin-11), but none have been clearly identified for v-SNAREs. α- Synuclein has been proposed as a v-SNARE chaperone which may affect SNARE-complex assembly, fusion pore opening, and thus secretion. Despite its abundance and that it is the only isoform present, α-synuclein’s role in platelet secretion is uncharacterized. In …

Openasap: An Affordable 3d Printed Atmospheric Solids Analysis Probe (Asap) Mass Spectrometry System For Direct Analysis Of Solid And Liquid Samples, Robert Samples, Rico Mukoyama, Jacob Shaffer, Jill Mikucki, Lesley Ann Giddings

Chemistry: Faculty Publications

Atmospheric Solids Analysis Probe (ASAP) mass spectrometry is a versatile technique allowing direct sampling of solid and liquid samples, but its adoption is limited due to the high cost of commercial ASAP systems. To address this, we present OpenASAP, an open-source ASAP system for mass spectrometers that can be fabricated for $20 or less using 3D-printing. Our design is readily adaptable to instruments from different manufacturers and can be produced with a variety of additive manufacturing techniques on consumer-grade 3D-printers. The probe allows for rapid sampling of solid and liquid samples without sample preparation, making it useful for high throughput …

Dean's Research Newsletter, November 2023, Neil W. Schluger

SOM Dean's Research Newsletter

No abstract provided.

Sar Study Of Niclosamide Derivatives For Neuroprotective Function In Sh-Sy5y Neuroblastoma, Shizue Mito, Benxu Cheng, Benjamin A. Garcia, Xin Yee Ooi, Daniela Gonzalez, Tess C. Ruiz, Francisco X. Elisarraras

School of Medicine Publications

Neurodegenerative disease is a debilitating and incurable condition that affects millions of people around the world. The loss of functions or malfunctions of neural cells are the causes of mortality. A proteosome inhibitor, MG132, is well known to cause neurodegeneration in vitro when model neuronal-derived cell lines are exposed to it. Niclosamide, an anthelmintic drug, which has been used to treat tapeworm infections for more than 50 years, has recently attracted renewed attention in drug repurposing because it has been found to be a good candidate in many drug development screenings. We recently found that all markers of MG132-induced neuronal …

Gelation Of Cytoplasmic Expanded Cag Rna Repeats Suppresses Global Protein Synthesis, Yuyin Pan, J Lu, Xinran Feng, S Lu, Y Yang, G Yang, Shudan Tan, Liang Wang, Pilong Li, Shouqing Luo, B Lu

Peninsula Medical School

RNA molecules with the expanded CAG repeat (eCAGr) may undergo sol–gel phase transitions, but the functional impact of RNA gelation is completely unknown. Here, we demonstrate that the eCAGr RNA may form cytoplasmic gel-like foci that are rapidly degraded by lysosomes. These RNA foci may significantly reduce the global protein synthesis rate, possibly by sequestering the translation elongation factor eEF2. Disrupting the eCAGr RNA gelation restored the global protein synthesis rate, whereas enhanced gelation exacerbated this phenotype. eEF2 puncta were significantly enhanced in brain slices from a knock-in mouse model and from patients with Huntington’s disease, which is a CAG …

Maternal Exposure To Ssris Or Snris And The Risk Of Congenital Abnormalities In Offspring: A Systematic Review And Meta-Analysis, Weiyi Huang, Robin Page, Theresa Morris, Susan Ayres, Alva Ferdinand, Samiran Sinha

Faculty Scholarship

Background

The association of maternal exposure to selective serotonin reuptake inhibitors (SSRIs) or serotonin and norepinephrine reuptake inhibitors (SNRIs) with the risk of system-specific congenital malformations in offspring remains unclear. We conducted a meta-analysis to examine this association and the risk difference between these two types of inhibitors.

Methods

A literature search was performed from January 2000 to May 2023 using PubMed and Web of Science databases. Cohort and case-control studies that assess the association of maternal exposure to SSRIs or SNRIs with the risk of congenital abnormalities were eligible for the study.

Results

Twenty-one cohort studies and seven case-control …

Both Horatio And Polonius: Innate Lymphoid Cells In Tissue Homeostasis And Repair, Intelly S Lee, Steven J Van Dyken

2020-Current year OA Pubs

Innate lymphoid cells (ILCs) have emerged as critical tissue-resident lymphocytes that coordinate responses to environmental stress and injury. Traditionally, their function was thought to mirror adaptive lymphocytes that respond to specific pathogens. However, recent work has uncovered a more central role for ILCs in maintaining homeostasis even in the absence of infection. ILCs are now better conceptualized as an environmental rheostat that helps maintain the local tissue setpoint during environmental challenge by integrating sensory stimuli to direct homeostatic barrier and repair programs. In this article, we trace the developmental origins of ILCs, relate how ILCs sense danger signals, and describe …

Epigenetic Regulation During Cancer Transitions Across 11 Tumour Types, Nadezhda V Terekhanova, Alla Karpova, Wen-Wei Liang, Siqi Chen, Yize Li, Austin N Southard-Smith, Michael D Iglesia, Michael C Wendl, Reyka G Jayasinghe, Jingxian Liu, Yizhe Song, Song Cao, Andrew Houston, Xiuting Liu, Matthew A Wyczalkowski, Rita Jui-Hsien Lu, Wagma Caravan, Andrew Shinkle, Nataly Naser Al Deen, John M Herndon, Jacqueline Mudd, Kazuhito Sato, Omar M Ibrahim, Chia-Kuei Mo, Sara E Chasnoff, Jason M Held, Russell Pachynski, Julie K Schwarz, William E Gillanders, Albert H Kim, Ravi Vij, John F Dipersio, Sidharth V Puram, Milan G Chheda, Katherine C Fuh, David G Denardo, Ryan C Fields, Feng Chen, Li Ding, Et Al.

2020-Current year OA Pubs

Chromatin accessibility is essential in regulating gene expression and cellular identity, and alterations in accessibility have been implicated in driving cancer initiation, progression and metastasis

A Human Mitofusin 2 Mutation Can Cause Mitophagic Cardiomyopathy, Antonietta Franco, Jiajia Li, Daniel P Kelly, Ray E Hershberger, Ali J Marian, Renate M Lewis, Moshi Song, Xiawei Dang, Alina D Schmidt, Mary E Mathyer, John R Edwards, Cristina De Guzman Strong, Gerald W Dorn

2020-Current year OA Pubs

Cardiac muscle has the highest mitochondrial density of any human tissue, but mitochondrial dysfunction is not a recognized cause of isolated cardiomyopathy. Here, we determined that the rare mitofusin (MFN) 2 R400Q mutation is 15-20× over-represented in clinical cardiomyopathy, whereas this specific mutation is not reported as a cause of MFN2 mutant-induced peripheral neuropathy, Charcot-Marie-Tooth disease type 2A (CMT2A). Accordingly, we interrogated the enzymatic, biophysical, and functional characteristics of MFN2 Q400 versus wild-type and CMT2A-causing MFN2 mutants. All MFN2 mutants had impaired mitochondrial fusion, the canonical MFN2 function. Compared to MFN2 T105M that lacked catalytic GTPase activity and exhibited normal …

A Consortium Of Microalgae And Wastewater Activated Sludge To Generate Biohydrogen, Muhammad Asad Javed

Dissertations

Hydrogen is a clean source and carbon-free source of energy that can be generated photobiologically using green microalgae with 122 kJ/g of energy output which is 2.75 times that of hydrocarbon-based fuels. However, challenges, such as presence of molecular oxygen (O₂) within the cells, hinder their practical application. Molecular O₂, emanating from the activity of photosynthesis, acts as a powerful and effective switch that turns off bioH₂ production activity. The objective of this research was to develop an innovative approach to increase the yield and sustain bioH₂ photoproduction. For this purpose, a consortium of …