Digital Commons Network^™

Msis-Kadelka: Algebraic Methods For Inferring Discrete Models Of Biological Networks, Brandilyn Stigler

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Gaff-Msis-Robertson: Assessing Lyme Disease Dynamics With Lymesim 2.0, Holly Gaff

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Msis-Kadelka: Canalization Reduces The Nonlinearity Of Regulation In Biological Networks, Claus Kadelka, David Murrugarra

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Msis-Ledder: Scaffolding Model Analysis With Agent-Based Models, Erin N. Bodine

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Mathematical Model Of Competing Nest Founding Strategies By Queen Harvester Ant Pogonomyremex Californicus, Tamantha Pizarro, Yun Kang

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

2023-24 Women In Science Conference Schedule (Pdf), Lynn University

Women in Science Conference

2023-24 Women in Environmental Science Conference Schedule (PDF)

Parathyroid Hormone Related Peptide Hypercalcemia As A Presentation Of Endometrial Clear Cell Carcinoma, Claudia Georges, Biplov Adhikari, Soumya Koundaveety, Robert Jones, Kalyan Paudel, Christopher Haas

Journal of Community Hospital Internal Medicine Perspectives

Hypercalcemia is a frequent complication of solid tumors and hematologic malignancies yet is only rarely associated with endometrial clear cell carcinoma. Here we report on a 70-year-old female who presented in the context of hip fracture and was incidentally found to have humoral hypercalcemia of malignancy secondary to endometrial clear cell carcinoma. This rare association makes endometrial cancer one of the differential diagnoses to be considered when assessing incidentally found symptomatic or asymptomatic hypercalcemia in the appropriate patient population.

The Unseen Danger Of Methotrexate Toxicity, Khalid Javed, Rashmi Wijeratne, Sumanth Kumar Bandaru

Journal of Community Hospital Internal Medicine Perspectives

Methotrexate is a commonly prescribed immunosuppressant and chemotherapy agent, which is closely monitored by healthcare providers for its adverse effects. As a result, methotrexate toxicity occurs infrequently. We present a case of a 51-year-old woman with a past medical history of rheumatoid arthritis on methotrexate and prednisone. She presented to the emergency room with altered mental status, jaundice, and mucosal ulceration. She was subsequently admitted to the intensive care unit for septic shock in the setting of severe pancytopenia, acute renal failure and acute liver failure. This case demonstrates the importance of recognizing the signs and symptoms of methotrexate toxicity …

Cryoglobulinemia Leading To The Diagnosis Of Low Grade Serous Ovarian Carcinoma, Garo Hagopian, Christopher Grant, Jerry Lou, Cary Johnson, Zahra Pakbaz

Journal of Community Hospital Internal Medicine Perspectives

We present the case of a 64-year-old female who was referred by her oncologist to benign hematology clinic for persistent asymptomatic cryoglobulinemia. Workup led to diagnosis of a rare low grade ovarian serous carcinoma. We briefly review the pathophysiology and clinical significance of cryoglobulinemia and the diagnosis and management of low grade serous ovarian carcinoma.

An Insight Into The Physicochemical, Drug-Likeness, Pharmacokinetics And Toxicity Profile Of Kigelia Africana (Lam) Bioactive Compounds, Sulyman Olalekan Ibrahim, Halimat Yusuf Lukman, Marili Funmilayo Zubair, Oluwagbemiga Tayo Amusan, Fatimah Ronke Abdulkadri, Bashir Lawal, Lateefat Bello Abdulfatah, Olubunmi Atolani

Al-Bahir

Kigelia africana plant is multipurpose plant whose therapeutic potential has been thoroughly investigated. The physicochemical, solubilities, ADMET, pharmacological, and drug-like properties of this plant have not been reported in details. This study makes use of the information that is currently known on the chemical make-up of the plant to forecast its overall toxicity as well as the potential for the phytochemicals it contains to be employed in medication discovery. The study also employed free web servers for the lipophilicity, water solubility, drug-likness, bioavailability score, medicinal chemistry and toxicological profiling of the compounds of K. africana. Artemether, a known antimalaria …

Deep Neural Network Based Tissue Deconvolution Of Circulating Tumor Cell Rna, Fengyao Yan, Limin Jiang, Fei Ye, Jie Ping, Tetiana Y. Bowley, Scott A. Ness, Chung-I Li, Dario Marchetti, Jijun Tang, Yan Guo

Pathology Research and Scholarship

Prior research has shown that the deconvolution of cell-free RNA can uncover the tissue origin. The conventional deconvolution approaches rely on constructing a reference tissue-specific gene panel, which cannot capture the inherent variation present in actual data. To address this, we have developed a novel method that utilizes a neural network framework to leverage the entire training dataset. Our approach involved training a model that incorporated 15 distinct tissue types. Through one semi-independent and two complete independent validations, including deconvolution using a semi in silico dataset, deconvolution with a custom normal tissue mixture RNA-seq data, and deconvolution of longitudinal circulating …

The Basic Dualism In The World, Martin Zwick

Complex Systems Faculty Publications and Presentations

Graham Harman writes that the “basic dualism in the world lies…between things in their intimate reality and things as confronted by other things.” This paper supports Harman’s assertion from a systems theoretic perspective and illustrates it with some examples, including conceptions about truth, ethics, value, and intelligence. But dualism implies irreconcilable difference; what Harman points to is better expressed as a dyad, where the two components not only imply one another but are related, and where this spatial dyad is usefully augmented with a temporal dimension, expressed in a third component or an additional orthogonal dyad.

Targeting Bet Proteins Downregulates Mir-33a To Promote Synergy With Pim Inhibitors In Cmml, Christopher T. Letson

USF Tampa Graduate Theses and Dissertations

Chronic Myelomonocytic Leukemia (CMML) is a rare myeloid malignancy with a dismal prognosis and no therapeutic options which are capable of altering the natural course of the disease. There remains a significant need for novel therapies that are able to meaningfully improve patient outcomes. In this study we explore the effectiveness of Bromodomain and Extra-Terminal domain protein inhibitor (BETi) combinations in CMML. Preclinical studies in myeloid neoplasms have demonstrated efficacy of BETi. However, BETi demonstrate poor single agent activity in clinical trials. Several studies suggest that combinations with other anti-cancer inhibitors may enhance the efficacy of BETi. To nominate BETi …

Coupling Chemical And Genomic Data Of Marine Sediment-Associated Bacteria For Metabolite Profiling, Stephanie P. Suarez

USF Tampa Graduate Theses and Dissertations

Marine sediment-associated bacteria house many new and exciting novel secondary metabolites. These metabolites can be tested for bioactivity against various types of cancer and fungal, bacterial, and viral infections. In this thesis, we investigated the combination of biosynthetic gene cluster information with mass spectra to perform a chemical profiling of sediment- associated bacteria. Furthermore, we utilized a scoring technique to provide an identification and confidence score to each annotated compound. The sediment was collected from east Arthur Harbor, Palmer Station, Antarctica, at depths of 20 ft and 60 ft. After plating on agar, 52 unique bacterial strains were isolated, with …

Immune Responses Induced At One Hour Post Cataract Surgery Wounding Of The Chick Lens, Jodirae Dedreu, Morgan Basta, Janice Walker, Sue Menko

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

While the lens is an avascular tissue with an immune-privileged status, studies have now revealed that there are immune responses specifically linked to the lens. The response to lens injury, such as following cataract surgery, has been shown to involve the activation of the resident immune cell population of the lens and the induction of immunomodulatory factors by the wounded epithelium. However, there has been limited investigation into the immediate response of the lens to wounding, particularly those induced factors that are intrinsic to the lens and its associated resident immune cells. Using an established chick embryo ex vivo cataract …

Mortality Index Analysis Following Traumatic Brain Injury In A Fruit Fly Model, Megan N. Ashworth, Kimberly D. Rowland

Faculty and Staff Publications & Presentations

No abstract provided.

Plasma Metabolomics And Quantitative Interstitial Abnormalities In Ever-Smokers, Bina Choi, Raúl San José Estépar, Suneeta Godbole, Jeffrey L Curtis, Jennifer M Wang, Rubén San José Estépar, Ivan O Rosas, Jared R Mayers, Brian D Hobbs, Craig P Hersh, Samuel Y Ash, Meilan K Han, Russell P Bowler, Kathleen A Stringer, George R Washko, Wassim W Labaki

Faculty, Staff and Students Publications

BACKGROUND: Quantitative interstitial abnormalities (QIA) are an automated computed tomography (CT) finding of early parenchymal lung disease, associated with worse lung function, reduced exercise capacity, increased respiratory symptoms, and death. The metabolomic perturbations associated with QIA are not well known. We sought to identify plasma metabolites associated with QIA in smokers. We also sought to identify shared and differentiating metabolomics features between QIA and emphysema, another smoking-related advanced radiographic abnormality.

METHODS: In 928 former and current smokers in the Genetic Epidemiology of COPD cohort, we measured QIA and emphysema using an automated local density histogram method and generated metabolite profiles …

Myth Or Fact? An Analysis Of Covid-19 Deaths In Red Versus Blue States Of America, Nishat Ara Mozid, Kwabena Sakyi Duku

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

A Mathematical Model Of Acanthocephalan Parasite Infection In Gull-Billed Terns, Charlotte Moser

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Estimating & Modeling The Growth Of Bromeliads, Erin N. Bodine, Helen O. Udeochu, Alana G. Wells

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Comparative Economic And Statistical Study About Fish Catch From Manzalah Before And During Dredging Operations For Developing The Lake’S Fisheries, Fattouh Sh, Abd El-Khalek Z., El-Sayed N., Hagag, Sh, Unis R., El- Sonbaty O.

Blue Economy

The bio, social, and economic sustainability of Lake Manzallah fisheries was affected because of pollution, dehydration, and fishers’ / outlaw encroachments. Fish catch and productivity have decreased sharply. The Egyptian government interfered in 2017 and introduced action plan for restoring the lake’s vitality. NIOF research team took part and conducted a research that aims at estimating the secular trend of total fish catch and of the major marine and brackish waters species: Tilapia, Catfish and Mullet, before and during the plan. The research also aims at assessing optimal catch-effort relation before and during the plan, and the effect of the …

Multicellular And Multiscale Models Of Microbes And Host Systems, Elebeoba May

Annual Symposium on Biomathematics and Ecology Education and Research

No abstract provided.

Peace Cafe, Ana Cynthia Saenz Jaimes

Peace and Conflict Studies Journal Conference

GAMIP Latin America presents Peace Cafe, a participatory and dialogued meeting space, virtual, face-to-face or hybrid, for critical reflection, study, promotion, and practices of Cultures of Peace. We want the exchange and respect of opinions and ideas without polarization.

Peace Cafe is for all GAMIP members and civil society actors, researchers, educational institutions, activists, business people, and governments. We hope to share a good coffee, listen and learning common issues and problems in the region.

This project is organized by GAMIP ALC and is supported for its execution by a registered member, by someone from an organization whose objectives are …

Green Synthesized Silver Nanoparticles-Based Sensing For Monitoring Water Pollution: An Updated Review, Muhamad Allan Serunting, Muhammad Ali Zulfikar, Henry Setiyanto, Dian Ayu Setyorini, Vienna Saraswaty

Karbala International Journal of Modern Science

Water is a basic human need and has been heavily contaminated. Therefore, it becomes a concern to remove the pollutant and monitor its quality. The removal methods include precipitation, filtration, adsorption, and photodegradation. Meanwhile, the monitoring can be done by measuring and analyzing the contaminant using spectrophotometry and chromatography. Nevertheless, those methods usually need a complicated preparation, and are expensive. Thus, a simple method is necessary to overcome these drawbacks by developing a sensor. In recent years, the sensor performance has been enhanced by using nanomaterials, such as silver nanoparticles (AgNPs). AgNPs can be synthesized using plant extracts through a …

Synthesis And Characterization Of Zirconium Oxide Nanoparticles Using Z. Officinale And S. Aromaticum Plant Extracts For Antibacterial Application, M. J. Tuama, M. F. A. Alias

Karbala International Journal of Modern Science

Abstract The dramatic rise in bacterial infections and increased resistance to conventional antibiotics has led to the exploration of biologically derived nanomaterials to counteract bacterial activity. Nanotechnology, which deals with materials at the atomic or molecular level, is a promising way to achieve this goal. Zirconium oxide nanoparticles (ZrO2NPs) have shown strong antibacterial effects due to the increased surface-to-volume ratio at the nanoscale. This study focused on the production of ZrO2NPs in an environmentally friendly manner, which included extracts from Zingiber officinale (ginger), where G-ZrO2NPs were produced, and Syzygium aromaticum (clove), which produced S-ZrO2NPs. Various techniques were used, such as …

Predicting A Rationale Weighted Criterion For Admission To Higher Education Institutions, Hala Abubaker Bagabir, Ahmed M. Bagabir Prof.

International Journal for Research in Education

Undergraduate selection, especially for medical degree programs, is a challenging and controversial matter for both national and international institutions. The importance of this paper lies in trying to identify the process of selecting prospective students for medical studies in Saudi Arabia. The currently applied admission criteria are the weighted average score (WAS) of the three pre-university attainments, the general secondary school (GSS), the general aptitude test (GAT), and the scientific achievement test (SAT). There is a different weightage assigned to WAS throughout the national medical institutions. It raises concern about the scientific rationale behind the differences. The present research correlates …

Comparative Analysis Of Swine Antibody Responses Following Vaccination With Live-Attenuated And Killed African Swine Fever Virus Vaccines, Hung Q. Luong, Huong T. L. Lai, Lam Q. Truong, The N. Nguyen, Hanh D. Vu, Hoa T. Nguyen, Lan T. Nguyen, Trang H. Pham, David Scott Mcvey, Hiep Vu

Nebraska Center for Virology: Faculty Publications

African swine fever virus (ASFV) is circulating in many swine-producing countries, causing significant economic losses. It is observed that pigs experimentally vaccinated with a live-attenuated virus (LAV) but not a killed virus (KV) vaccine develop solid homologous protective immunity. The objective of this study was to comparatively analyze antibody profiles between pigs vaccinated with an LAV vaccine and those vaccinated with a KV vaccine to identify potential markers of vaccineinduced protection. Thirty ASFV seronegative pigs were divided into three groups: Group 1 received a single dose of an experimental LAV, Group 2 received two doses of an experimental KV vaccine, …

Starting The Journey To Excellence With A College Faculty Onboarding Program, Robin Cooper, Judith Slapak-Barski

HCAS Instructional Design and Pedagogy

The journey to engaged, excellent teaching requires support and preparation for those doing the teaching. In this session, we describe a college Faculty Onboarding Program we developed in 2023 to introduce our new Halmos faculty to NSU (Nova Southeastern University) and to Halmos, and to provide them with the resources and information needed to succeed in their new role—driven by the belief that effective onboarding will lead to higher job satisfaction, better job performance, greater organizational commitment, and reduction in stress. Informed by feedback from recently hired faculty, we identified support strategies to help new faculty thrive by proactively removing …

The Student Movement Volume 108 Issue 7: Not Throwing Away Our Shot: Honoring Hamilton's Legacy, Anneliese Tessalee, Nick Bishop, Grace No, Madison Vath, Amelia Stefanescu, Katrina Johnson, Reagan Mccain, Andrew Francis, Melissa Moore, Brendan Oh, Abby Shim, Reagan Westerman, Robert Zhang, Nicole Compton-Gray, Katie Davis, Anna Rybachek, Rodney Bell Ii, Wambui Karanja

The Student Movement v. 108 (2023-2024)

HUMANS

An Arboretum of Beauty, Anneliese Tessalee

Serving with All She's Got: Natalia's Mission Experience in the Dominican Republic, Nick Bishop

WAUS Fall Fundraiser, Grace No

ARTS & ENTERTAINMENT

Art: A Window Into Another Reality, Madison Vath

Filipino Art Through Filipino Eyes: Celebrating A Culture, Amelia Stefanescu

"Free-Falling Into Autumn": A Fall Playlist, Amelia Stefanescu

Upcoming Events in the Art Department, Katrina Johnson

What to do about Inhospitality?: A Review of Mitski's Newest Album, Reagan McCain

NEWS

Andrews Autumn Conference Promotes Peaceful Scientific Discourse, Andrew Francis

Honors Goes to Hamilton, Melissa Moore

Unraveling the Historical Threads: The SDA Church's Journey …

Reduced Grey Matter Volume In Adolescents With Conduct Disorder: A Region‑Of‑Interest Analysis Using Multivariate Generalized Linear Modeling, Ru Zhang, Robert James R. Blair, Karina S. Blair, Matthew Dobbertin, Jaimie Elowsky, Johannah Bashford‑Largo, Ahria J. Dominguez, Melissa Hatch, Sahil Bajaj

Center for Brain, Biology, and Behavior: Faculty Publications

Background

Conduct disorder (CD) involves a group of behavioral and emotional problems that usually begins during childhood or adolescence. Structural brain alterations have been observed in CD, including the amygdala, insula, ventrolateral and medial prefrontal cortex, anterior cingulate cortex, and fusiform gyrus. The current study developed a multivariate generalized linear model (GLM) to differentiate adolescents with CD from typically developing (TD) adolescents in terms of grey matter volume (GMV).

Methods

The whole‐brain structural MRI data were collected from 96 adolescents with CD (mean age = 16.188 ± 1.259 years; mean IQ = 104.292 ± 8.107 ; 63 males) and 90 …