Digital Commons Network^™

Cytomulate: Accurate And Efficient Simulation Of Cytof Data, Yuqiu Yang, Kaiwen Wang, Zeyu Lu, Tao Wang, Xinlei Wang

Faculty, Staff and Student Publications

Recently, many analysis tools have been devised to offer insights into data generated via cytometry by time-of-flight (CyTOF). However, objective evaluations of these methods remain absent as most evaluations are conducted against real data where the ground truth is generally unknown. In this paper, we develop Cytomulate, a reproducible and accurate simulation algorithm of CyTOF data, which could serve as a foundation for future method development and evaluation. We demonstrate that Cytomulate can capture various characteristics of CyTOF data and is superior in learning overall data distributions than single-cell RNA-seq-oriented methods such as scDesign2, Splatter, and generative models like LAMBDA.

Kenyon Collegian - November 16, 2023

The Kenyon Collegian

No abstract provided.

November 16, 2023, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Loss Of Cftr Function In Macrophages Alters The Cell Transcriptional Program And Delays Lung Resolution Of Inflammation, Dianne Wellems, Yawen Hu, Scott Jennings, Guoshun Wang

School of Graduate Studies Faculty Publications

Cystic fibrosis (CF) is an autosomal recessive genetic disorder caused by mutations in the CF Transmembrane-conductance Regulator (CFTR) gene. The most severe pathologies of CF occur in the lung, manifesting as chronic bacterial infection, persistent neutrophilic inflammation, and mucopurulent airway obstruction. Despite increasing knowledge of the CF primary defect and the resulting clinical sequelae, the relationship between the CFTR loss of function and the neutrophilic inflammation remains incompletely understood. Here, we report that loss of CFTR function in macrophages causes extended lung inflammation. After intratracheal inoculation with Pseudomonas aeruginosa, mice with a macrophage-specific Cftr-knockout (Mac-CF) were able to mount an …

Two Phase 3 Trials Of Gantenerumab In Early Alzheimer's Disease, Randall J Bateman, Et Al.

2020-Current year OA Pubs

BACKGROUND: Monoclonal antibodies that target amyloid-beta (Aβ) have the potential to slow cognitive and functional decline in persons with early Alzheimer's disease. Gantenerumab is a subcutaneously administered, fully human, anti-Aβ IgG1 monoclonal antibody with highest affinity for aggregated Aβ that has been tested for the treatment of Alzheimer's disease.

METHODS: We conducted two phase 3 trials (GRADUATE I and II) involving participants 50 to 90 years of age with mild cognitive impairment or mild dementia due to Alzheimer's disease and evidence of amyloid plaques on positron-emission tomography (PET) or cerebrospinal fluid (CSF) testing. Participants were randomly assigned to receive gantenerumab …

Bureaucratic Politics Run Amok: The United States And Satellite Export Controls, Eligar Sadeh

Space and Defense

The case of export controls of United States (U.S.) commercial satellites is characterized by bureaucratic politics leading to policy outcomes that are not rational, i.e., the desired outcome of national security is not met and commerce in the satellite sector is harmed. The constraints to rational policy making are a result of competition, conflict, and protectionism, the “bureaucratic politics,” among the relevant actors including the U.S. President and Congress, Department of State (State), Department of Commerce (Commerce), and Department of Defense (DOD). It is bureaucratic politics that result in policies for licensing the export of commercial satellites that are far …

Kosovo Specialist Court: Sovereignty Infringement And The Risk Of A New Precedent, Valëza Kastrati

Ohio Northern University International Law Journal

The Kosovo Specialist Chambers and Specialist Prosecutor’s Office, otherwise known as the Kosovo Specialist Court (KSC), was established in 2015, thus presenting the most recent mechanism to adjudicate war crimes and crimes against humanity related to the Kosovo War of 1998-1999. Its formation has led to numerous unresolved questions, particularly in regard to the implications between international courts and national (domestic) courts. Holding the epithet of being a hybrid court in theory, while also showing elements of an international court in reality, has brought doubts that such courts can indeed be established by simply revealing another perception of it. The …

University Of Nebraska-Lincoln Agricultural Research Division 121st Annual Report. July 1, 2006 To June 30, 2007., Institute Of Agriculture And Natural Resources

Agricultural Research Division: News and Annual Reports

Our Mission..... 4

Foreword..... 5

Research Highlights..... 6

Faculty Awards and Recognitions....14

Graduate Student Awards and Recognitions...17

Undergraduate Honors Student Research Program...22

Variety and Germplasm Releases....23

Patents.....24

Administration.....25

Administrative Personnel....25

Organizational Chart....26

Administrative Units....27

IANR Research Facilities....28

Faculty.....29

Agricultural/Natural Resources Units....30

Education and Human Sciences Departments...39

Off-Campus Research Centers....40

Interdisciplinary Activities....41

Visiting Scientists/Research Associates....42

Research Projects.....47

Agricultural/Natural Resources Units....47

Education and Human Sciences Departments...52

Off-Campus Research Centers....52

Interdisciplinary Activities....53

Publications.....55

Agricultural/Natural Resources Units....60

Education and Human Sciences Departments...82

Off-Campus Research Centers....85

Research Expenditures....88

Regression-Based Models For Predicting Discharge Coefficient Of Triangular Side Orifice, Mohamed Elshaarawy, A. K. Hamed, Saad Hamed

Journal of Engineering Research

- This study introduced another technique to predict the discharge coefficient (Cd) of the triangular side orifice (TSO). This technique is based on the SPSS software as multiple linear regression (MLR) and multiple nonlinear regression (MNLR) models. These models were established using 570 experimental datasets, 70 and 30% for calibration and testing stages, respectively. These sets considered five non-dimensional parameters, including (orifice crest height, orifice length, orifice height, upstream flow depth, and Froude number of the main channel). Results showed that the MLR and MNLR models in the calibrating stage had higher determination coefficients and lower errors. In addition, the …

Sustainable Waste Management Through The Lens Of Artificial Intelligence: An In-Depth Review, Noha Emad El-Sayad, Shereen Zakaria

Journal of Engineering Research

One of the major issues facing the world, particularly developing countries, is waste management. “Waste” is any material that is not needed or has no intended use. Neglecting this waste endangers the safety of the public and causes harm, as it emits dangerous gases that have negative effects on human health. Egypt has made distinguished efforts to achieve the goals of Egypt Vision 2030 and the Sustainable Development Goals. These efforts, which have been implemented through massive government projects throughout the past few years and are set to be followed by more in the future, still require a lot of …

Path Planning For A 6 Dof Robotic Arm Based On Whale Optimization Algorithm And Genetic Algorithm, Mahmoud A. A. Mousa, Abdelrahman Tarek Elgohr, Hatem Khater

Journal of Engineering Research

The trajectory planning for robotic arms is a significant area of research, given its role in facilitating seamless trajectory execution and enhancing movement efficiency and accuracy. This paper focuses on the development of path planning algorithms for a robotic arm with six degrees of freedom. Specifically, three alternative approaches are explored: polynomial (cubic and quantic), Whale Optimization Algorithm (WOA), and Genetic Algorithm (GA). The comparison of outcomes between different methods revealed that polynomial methods were found to be more straightforward to implement, albeit constrained by the intricacy of the pathway. Upon examining the functioning of the WOA, it has been …

Environmentally Friendly Wastewater Treatment In Egypt: Opportunities And Challenges, Mohamed Gabr

Journal of Engineering Research

The uncontrolled and untreated discharge of significant amounts of wastewater into water bodies, including lakes, rivers, and streams, as a result of population growth, has resulted in a number of environmental and health problems. At the local and municipal levels, many processes are traditionally used for wastewater treatment. It is essential to comprehend all accessible methods and assess their effectiveness because of the growing demand for and development of newer technology. Reusing various agricultural, municipal, and industrial wastes is a workable solution to Egypt's water needs due to the country's limited water supply and gradually rising water demand. The Egyptian …

Parents’ Emotional And Psychological Perspective Of Caring Children With Oncological Disorders: A Descriptive Qualitative Study, Ambreen Navroz Ali Salyani

MSCN 2023

Background: Childhood cancer has a profound effect on the emotional and psychological well-being of parents, yet often their own psychological health is overlooked as the primary focus while treating the child. These parents silently suffer from psychological distress while caring for their children. They use their own coping strategies to overcome the situation. However, limited studies have been carried out in low- and middle-income countries (LMIC) regarding parents’ emotional and psychological perspectives of caring their children with oncological disorder.
Purpose: The objective of this study was to explore the psychological perspectives that parents of children with cancer diagnosis, treatment, social …

The Permanence Of Racism In Tennessee Public Schools, Jarral Yokley

Dissertations

The qualitative case study exposed the permanence of racism beginning in the antebellum public schools of Nashville and continued in the current actions in the Tennessee legislature with the expulsion of two Black male legislators. Critical race theory is used as the main descriptor for the actions of White politicians and legislators in Tennessee who continue the oppressive treatment of Black people in the state of Tennessee.

White members of the Tennessee legislature have attempted to strategically continue white supremacy in their decision to display a depiction of one of the most deplorable, racists in the history of the state …

Conceptual Meaning In Phonology: Multimodal Iconic Expressions In Discourse Focus, David Páez Acevedo

Linguistics ETDs

In everyday communication, speakers go beyond words to synchronize speech sounds and gestures, adding nuanced meanings. For instance, in Colombian Spanish, recounting the distant past involves elongating words, modulating pitch, and using expressive hand movements. This dissertation explores this phenomenon, termed Multimodal Iconic Expressions (MMIEs), using Cognitive Linguistics and Cognitive Grammar. The quantitative study uncovers correlations between verb aspect, nominal quantification, and speech duration, revealing phono-iconic connections. The qualitative study examines construal operations giving rise to MMIEs across semantic domains. MMIEs predominantly appear in discourse Focus, with durative events and mass-like quantities exhibiting pronounced phono-iconic associations. Patterns include stress and …

Evolutionary Conservation And Times Of Action Of Heterochronic Genes, Maria Ivanova

Theses and Dissertations

The heterochronic pathway of C. elegans is the most well-characterized system to date for controlling the sequence and timing of developmental events. However, we still have critical unanswered questions to address. First, little is known about the evolution of the heterochronic pathway, and of developmental timing in general. To determine if the roles of major heterochronic genes are conserved, I made mutants in orthologs of these genes in C. briggsae, using CRISPR/Cas9. My studies revealed a significant drift in the roles of some of the genes, although all of them are still involved in the developmental timing regulation, and several …

One And Done - A Process For Improving Chg Bathing Compliance, Michelle R. Johnson

Nursing Research & Professional Development Conference

The prevention of hospital-acquired infections is a growing topic in healthcare. This has resulted in an increased focus being placed on CHG bathing, as it helps to reduce the patients’ risk for developing infections while hospitalized, as well as the associated costs. At Carolinas Rehabilitation, the expectation is that all patients who have central lines inserted and those who have tested positive for MRSA infections will receive CHG daily CHG baths for a specified period. Chart audits helped to confirm the lack of consistency with getting the CHG baths completed and/or documented by our Nursing and Therapy teammates.

We tried …

Learning Lichen, Laura Temple

The Goose

This creative nonfiction piece follows an environmental educator’s journey of walking with children through the boreal fog forest of Newfoundland and Labrador’s Avalon Peninsula in the weeks after a hurricane. Noticing the bits of lichen that have fallen off trees and are now coating the forest floor and trails, she reflects on learning, climate disruption, how we relate to each other, and what lichen has to teach us.

Fall 2023 Student Showcase For Research And Creative Inquiry Program, Office Of Student Research, Longwood University

Fall Showcase for Research and Creative Inquiry

No abstract provided.

Black Women's Experiences Of Receiving Telemedicine Prenatal Care During Covid-19, Dorothy Hiralien

Walden Dissertations and Doctoral Studies

No abstract provided.

Student Senate Meeting Minutes November 15, 2023, Student Senate-Winona State University

Student Senate Meeting Minutes

This document is the official Winona State University Student Senate Minutes November 15, 2023.

Tandem Travel: Reconsidering Road Narratives And Tactics For Subversive Travel, Nicole Emanuel

The Goose

Roads are frequently conceptualized as shared spaces that symbolize freedom, despite the fact that they are also tightly monitored sites where laws and public policy hold sway. The fundamental tension between movement on the one hand and restrictive regulation on the other makes the road a particularly paradoxical expression of “the commons.” Another contradictory aspect of roads is that they are often understood as atopic—places that are not really places, but merely a means of conquering time and space to connect a point of origin to a destination. What does it mean to live one’s daily life in such a …

Strolling And Scrolling: On Mycologies And Queer Environmental Futures, Sabine Lebel

The Goose

This essay uses queer mycologies to advocate for radical rest in the face of anti-queer organizing and hate. The author explains how a burnout diagnosis forced her out of the office and into the woods with her dog. Learning to walk the dog on a leash precipitated a deep queer kinship with the dog, mushrooms, and slide molds in the Acadian forest.

2023-11-15 Homecoming 2023: Home Is Where The Hawk Is, George Burquest

The Spectator Online

No abstract provided.

2023-11-15 Redhawks Men’S Basketball Earns Riveting Homecoming Win, Bridget Lawrence

The Spectator Online

No abstract provided.

Phenological Activities Of Desert Bees Track Rainfall More Than Temperature And Predict Temporal Abundance Trends Over 16 Years, Jade Elijah Mclaughlin

Biology ETDs

Phenology, the timing of recurrent biological events, is a key mechanism by which species adapt or acclimatize to variable environmental conditions, including those influenced by climate change. Measurable traits, including the onset and end of activity, peak activity, and duration, characterize the phenology of life events, and could be significant predictors of trends in population abundance or stability in a changing climate. Bees provide critical pollination services, and understanding the covariates of bee phenological traits can refine predictions on the vulnerabilities of bees and their services to climate change. We paired 16 years of monthly bee survey data (2002-2019) with …

University Philharmonic Orchestra & Cooke Scholarship String Quartets

Bailey School of Music Concert Programs

Program for the University Philharmonic Orchestra & Cooke Scholarship String Quartets performance on November 15, 2023.

Exploring The Mind Of The Domestic Feline, Felice A. Murden

Electronic Theses and Dissertations Archive

The domestic feline has lived among humans for thousands of years, dispersing across the world as they provided companionship along trade routes. But, as this relationship has persisted, the cognition of these pets is seldom studied compared to other companion animals. Cats have become the second largest population of companion animals following dogs. Much of what is perceived about the cognition of these animals is anecdotal; empirical evidence is needed. These studies examine three aims to enrich the growing literature on feline cognition in the areas of quantity discrimination, episodic memory, and individual recognition. A total of 130 domestic cats, …

Integrating A Virtual Science Outreach Into The Science Classroom Through Participatory Action Research, Shelby Anne Montague

Electronic Theses and Dissertations Archive

Calls for increased involvement in science outreach have come from scientists (Alberts, 2018; Friedman, 2008), from professional organizations (Jayaratne et al., 2003; Lee, 2018; Toolin, 2004) and from funding agencies (Broadening Participation, 2008; Catsambis, 1995) to increase students’ interest in science, technology, engineering, and mathematics (STEM) and STEM careers. One model of science outreach is the scientist in the classroom model, where a STEM professional visits a school classroom either in-person (Peker et al., 2012; Pratt and Yezierski, 2018) or virtually (Barry et al., 2022; McCombs et al., 2007). The St. Jude Virtual Journal Club is a scientist in the …

The Lumberjack, November 15, 2023

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.