Digital Commons Network^™

Unraveling The Impact Of Trap-Neuter-Release (Tnr) Programs On Feral Cat Populations, Emma Koch

Honors Theses

Trap-Neuter-Return (TNR) is a humane and effective method for managing outdoor cat populations. The process involves trapping feral or free-roaming cats, sterilizing them, and then returning them to their original location. While sterilization is crucial in curbing population growth, successful TNR programs require more than just the surgical aspect. Vetting is essential for addressing health concerns and ensuring the overall well-being of the cats. Moreover, colony care, including regular feeding and monitoring, is vital for their survival. Outdoor cats, often considered an invasive species, pose a threat to local wildlife and natural habitats. TNR provides a humane and long-lasting solution …

Solar Radiation Modification Governance In The Context Of Temperature Overshoot, Janos Pasztor

New England Journal of Public Policy

As the climate crisis escalates, governments—and recently even those in the wealthier countries in the Global North—are struggling to manage the impacts we are experiencing around the world in frightening abundance, including record-setting temperatures, fires, floods, and glacial and ice melt. Behind closed doors, policymakers are concerned as they contemplate the increasing likelihood, even under the most ambitious emission reduction pathways, that the world will overshoot the goal agreed upon in the Paris Agreement to limit global average temperature rise to 1.5oC beyond pre-industrial levels.

It is in this “overshoot context” that interest is growing in an emerging, potentially supplementary …

Breaking The Loop: Strategies For Fighting Climate Change On U.S. Farms, Ashley Barry

Honors Capstones

Climate change is an increasingly urgent area of research due to the hardships it causes for lands and communities across the globe. Specifically in regard to the United States (U.S.), climate change has many concerning implications on our agricultural system. Increased weather hazards, decreased crop production, and drought are just a few of the hardships American farmers are facing in their fight to keep their farms alive and feed their communities, despite a rapidly changing climate. This study investigates how farmers can fight and prevent climate change through the use of specific mitigation and adaptation strategies on their farms. Semi- …

Frailty Index In The Colonias Of The Rio Grande Valley: Health Related Quality Of Life And Resilience, Eron G. Manusov, Vincent P. Diego, Sarah Williams-Blangero

School of Medicine Publications

Background: Frailty is characterized by an accumulation of deficits that lead to vulnerability to adverse health outcomes. The Frailty Index (FI) quantifies frailty by measuring deficits that increase susceptibility to stressors. This study focused on a population of Mexican Americans living in vulnerable communities in the Rio Grande Valley of south Texas. We used a Frailty Index developed based on common health-related data--the Patient Health Questionnaire (PHQ-9) and a Health-related Quality of Life survey (Duke Health Profile). Quality of life, resilience, and frailty are interrelated and influenced by chronic illness, mental illness, poverty, cognitive impairment, and community support.

Methods: We …

Covid-19 Vaccination, Acceptance, Safety, And Side-Effects In European Patients With Severe Asthma, Apostolos Bossios, Alison M. Bacon, Katrien Eger

School of Psychology

Background Vaccination is vital for achieving population immunity to severe acute respiratory syndrome coronavirus 2, but vaccination hesitancy presents a threat to achieving widespread immunity. Vaccine acceptance in chronic potentially immunosuppressed patients is largely unclear, especially in patients with asthma. The aim of this study was to investigate the vaccination experience in people with severe asthma. Methods Questionnaires about vaccination beliefs (including the Vaccination Attitudes Examination (VAX) scale, a measure of vaccination hesitancy-related beliefs), vaccination side-effects, asthma control and overall safety perceptions following coronavirus disease 2019 (COVID-19) vaccination were sent to patients with severe asthma in 12 European countries between …

Joint Global Responsibility Fund For Climate, Conservation, And Communities: A Proposed Innovative Tax-Based Funding Mechanism, Tamar Ron

New England Journal of Public Policy

Nature-based solutions address biodiversity loss, climate change, and societal challenges at the local, national, regional, and global levels. The costs of their conservation, however, are mostly local and national in nature. Confronting the rolling dual crisis of biodiversity loss and climate change requires us to recognize nature’s intrinsic value. Moreover, we must find practical ways for their monetary valuation to be channeled as payment for the services of conservation custodians. It is suggested here to translate the value of natural assets and the understanding of the local costs and global benefits of their conservation, into an innovative and ambitious funding …

The Sw-5b Nlr Immune Receptor Induces Early Transcriptional Changes In Response To Thrips And Mechanical Modes Of Inoculation Of Tomato Spotted Wilt Orthotospovirus, Norma A. Ordaz, Ugrappa Nagalakshmi, Leonardo S. Boiteux, Hagop S. Atamian Dr., Diane E. Ullman, Savithramma P. Dinesh-Kumar

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The NLR (nucleotide-binding leucine-rich repeat) class immune receptor Sw-5b confers resistance to Tomato spotted wilt orthotospovirus (TSWV). Although Sw-5b is known to activate immunity upon recognition of the TSWV movement protein NSm, we know very little about the downstream events that lead to resistance. Here, we investigated the Sw-5b–mediated early transcriptomic changes that occur in response to mechanical and thrips-mediated inoculation of TSWV, using near-isogenic tomato lines CNPH-LAM 147 (Sw5b^+/+) and Santa Clara (Sw-5b^−/−). We observed earlier Sw-5b–mediated transcriptional changes in response to thrips-mediated inoculation compared with that in response to mechanical …

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Rcc2 Promotes Prostate Cancer Cell Proliferation And Migration Through Hh/Gli1 Signaling Pathway And Cancer Stem-Like Cells, Shenghan Wang, Zhentao Lei, Wei Liu, Jie Xiong, Yuqiang Shi, Lin Yang, Qiang Gao, Kai Le, Bao Zhang

Faculty, Staff and Student Publications

BACKGROUND: Regulator of chromosome condensation 2 (RCC2) was a telophase disk-binding protein on mitosis, and functions as an oncogene in many human cancers. However, its role on prostate cancer (PCa) was unknown. The goal of this study is to explore the function of RCC 2 on PCa development.

METHODS: The expression of RCC2 and its methylation level, its correlation with lymph node metastasis or disease-free survival (DFS) was analyzed using TCGA database. The effect of RCC2 on PCa cell proliferation, migration and invasion were detected using CCK-8, cell colony formation, Transwell and wood healing assays. RNA-seq and GSEA analysis were …

Quality Of Life Is Lower In Food Allergic Adolescents Compared To Young Children At A Community Educational Symposium, Diem-Tran I Nguyen, Kathleen Pitts, Kristen A Staggers, Carla M Davis

Faculty, Staff and Students Publications

INTRODUCTION: Food allergies (FA) can detrimentally impact physical, emotional, and psychological quality of life (QoL) among pediatric patients. Given the changes from childhood into adolescence, the impact of FA on QoL likely evolves with age. The purpose of this study was to determine whether QoL differed between adolescents and children with FA who participated in a Food Allergy Symposium (FAS).

METHODS: Patients with confirmed FA were recruited at an educational community symposium in September 2018 and September 2019. Patients and/or their parents were invited to complete the Food Allergy Quality of Life Questionnaires (FAQLQ). The Food Allergy Independent Measure (FAIM) …

Amphibian Diversity Across Three Adjacent Ecosystems In Área De Conservación Guanacaste, Costa Rica, Alex W. Edwards, Xavier A. Harrison, M. Alex Smith, Mm Chavarria, Mahmood Sasa, Daniel H. Janzen, Winnie Hallwachs, Gerardo Chaves, R Fernandez, Caroline Palmer, Chloe Wilson, Alexandra North, Robert Puschendorf

School of Biological and Marine Sciences

Amphibians are the most threatened species-rich vertebrate group, with species extinctions and population declines occurring globally, even in protected and seemingly pristine habitats. These ‘enigmatic declines’ are generated by climate change and infectious diseases. However, the consequences of these declines are undocumented as no baseline ecological data exists for most affected areas. Like other neotropical countries, Costa Rica, including Área de Conservación Guanacaste (ACG) in north-western Costa Rica, experienced rapid amphibian population declines and apparent extinctions during the past three decades. To delineate amphibian diversity patterns within ACG, a large-scale comparison of multiple sites and habitats was conducted. Distance and …

Single-Cell Multiomics Of The Human Retina Reveals Hierarchical Transcription Factor Collaboration In Mediating Cell Type-Specific Effects Of Genetic Variants On Gene Regulation, Jun Wang, Xuesen Cheng, Qingnan Liang, Leah A Owen, Jiaxiong Lu, Yiqiao Zheng, Meng Wang, Shiming Chen, Margaret M Deangelis, Yumei Li, Rui Chen

Faculty, Staff and Students Publications

BACKGROUND: Systematic characterization of how genetic variation modulates gene regulation in a cell type-specific context is essential for understanding complex traits. To address this question, we profile gene expression and chromatin accessibility in cells from healthy retinae of 20 human donors through single-cell multiomics and genomic sequencing.

RESULTS: We map eQTL, caQTL, allelic-specific expression, and allelic-specific chromatin accessibility in major retinal cell types. By integrating these results, we identify and characterize regulatory elements and genetic variants effective on gene regulation in individual cell types. The majority of identified sc-eQTLs and sc-caQTLs display cell type-specific effects, while the cis-elements containing genetic …

Single-Cell Multiomics Of The Human Retina Reveals Hierarchical Transcription Factor Collaboration In Mediating Cell Type-Specific Effects Of Genetic Variants On Gene Regulation, Jun Wang, Xuesen Cheng, Qingnan Liang, Leah A Owen, Jiaxiong Lu, Yiqiao Zheng, Meng Wang, Shiming Chen, Margaret M Deangelis, Yumei Li, Rui Chen

2020-Current year OA Pubs

BACKGROUND: Systematic characterization of how genetic variation modulates gene regulation in a cell type-specific context is essential for understanding complex traits. To address this question, we profile gene expression and chromatin accessibility in cells from healthy retinae of 20 human donors through single-cell multiomics and genomic sequencing.

RESULTS: We map eQTL, caQTL, allelic-specific expression, and allelic-specific chromatin accessibility in major retinal cell types. By integrating these results, we identify and characterize regulatory elements and genetic variants effective on gene regulation in individual cell types. The majority of identified sc-eQTLs and sc-caQTLs display cell type-specific effects, while the cis-elements containing genetic …

Regression-Based Models For Predicting Discharge Coefficient Of Triangular Side Orifice, Mohamed Elshaarawy, A. K. Hamed, Saad Hamed

Journal of Engineering Research

- This study introduced another technique to predict the discharge coefficient (Cd) of the triangular side orifice (TSO). This technique is based on the SPSS software as multiple linear regression (MLR) and multiple nonlinear regression (MNLR) models. These models were established using 570 experimental datasets, 70 and 30% for calibration and testing stages, respectively. These sets considered five non-dimensional parameters, including (orifice crest height, orifice length, orifice height, upstream flow depth, and Froude number of the main channel). Results showed that the MLR and MNLR models in the calibrating stage had higher determination coefficients and lower errors. In addition, the …

Sustainable Waste Management Through The Lens Of Artificial Intelligence: An In-Depth Review, Noha Emad El-Sayad, Shereen Zakaria

Journal of Engineering Research

One of the major issues facing the world, particularly developing countries, is waste management. “Waste” is any material that is not needed or has no intended use. Neglecting this waste endangers the safety of the public and causes harm, as it emits dangerous gases that have negative effects on human health. Egypt has made distinguished efforts to achieve the goals of Egypt Vision 2030 and the Sustainable Development Goals. These efforts, which have been implemented through massive government projects throughout the past few years and are set to be followed by more in the future, still require a lot of …

Path Planning For A 6 Dof Robotic Arm Based On Whale Optimization Algorithm And Genetic Algorithm, Mahmoud A. A. Mousa, Abdelrahman Tarek Elgohr, Hatem Khater

Journal of Engineering Research

The trajectory planning for robotic arms is a significant area of research, given its role in facilitating seamless trajectory execution and enhancing movement efficiency and accuracy. This paper focuses on the development of path planning algorithms for a robotic arm with six degrees of freedom. Specifically, three alternative approaches are explored: polynomial (cubic and quantic), Whale Optimization Algorithm (WOA), and Genetic Algorithm (GA). The comparison of outcomes between different methods revealed that polynomial methods were found to be more straightforward to implement, albeit constrained by the intricacy of the pathway. Upon examining the functioning of the WOA, it has been …

Environmentally Friendly Wastewater Treatment In Egypt: Opportunities And Challenges, Mohamed Gabr

Journal of Engineering Research

The uncontrolled and untreated discharge of significant amounts of wastewater into water bodies, including lakes, rivers, and streams, as a result of population growth, has resulted in a number of environmental and health problems. At the local and municipal levels, many processes are traditionally used for wastewater treatment. It is essential to comprehend all accessible methods and assess their effectiveness because of the growing demand for and development of newer technology. Reusing various agricultural, municipal, and industrial wastes is a workable solution to Egypt's water needs due to the country's limited water supply and gradually rising water demand. The Egyptian …

Episode 5: Fair's Fair, Sara Gras

Season 01

One of the most commonly expressed objections to the inclusion of trans athletes is that it is fundamentally unfair, particularly to cis women and girls, to compete against trans women and girls. While this cultural belief may be ubiquitous, the science behind it is far from black and white. Without any substantive, multi-sport studies that include trans youth, much of the "evidence" of unfair advantage is merely inferred from other studies of biological difference. But with so much on the line for an already-marginalized community, we should be wary when anyone tries to justify exclusion solely on loose correlations between …

Pharmacogenomic Precision Medicine: Best Practice Toolkit For Improving Patient Screening For Adult Metastatic Cancer Patients, Rena L. Stewart

Student Scholarly Projects

Precision medicine utilizes pharmacogenomic testing as a therapeutic approach. Genomic testing can assess the impact of an individual's genome on their reaction to specific medications. The main objective is to find variants that may affect an individual's response to a given medication. The implementation of pharmacogenomics in oncology facilitates informed decision-making by clinicians in drug selection and dosage determination.

Notions Of Liberty- Traditional And Modern, Zachary D. Weston

Honors Theses

This essay examines, primarily, how notions of liberty have evolved over time in America. Starting from the point of establishing America’s foundation in Thomistic natural law, the essay then seeks to identify, define, and analyze different segments of American political thought that have sprung off from this staring point. Three segments are identified, Conservatism, Liberalism, and Progressivism, and then defined on how they view the self. The conservatives from God, the liberals from reason, and the progressives from how the individual interacts with society. After this, these different segments of American political thought are contrasted by viewing how they offer …

Lakota Ethnobotany For The First Graders, Mikayla A. Janis, Michael. A. Little Eagle, Madhav P. Nepal

iLEARN Teaching Resources

In this lesson, students explore the Ethnobotany of the Lakota people, learning about the deep connection between the Lakota culture and native plants. Through a Schoolyard Walk or a Nature Walk, they observe and learn the Lakota names of three plants, their uses and importance to the Lakota people. Students engage in discussions and storytelling, understanding how these plants are like friends to the Lakota, serving various purposes such as in ceremonies or as food sources. The hands-on craft activity allows them to express what they learn by coloring plant parts and conceptualizing the life cycle of a plant. Overall, …

A Phenomenological Study Of Barriers And Needs Related To Opioid Prevention, Treatment, And Recovery In Rural Alabama, Joshua C. Eyer, Cho Rong Won, Megan Sawyer, Yan Luo, Kun Wang, Edson Chipalo, Gwen Thomas-Leblanc, Hee Lee

The Qualitative Report

Rural areas with limited access to preventive care, treatment, and recovery services are particularly affected by the opioid crisis. This study identified four rural areas in Alabama that had higher opioid prescription rates than the state and national average. This study explores the views of three groups [healthcare service providers, persons who use/used opioids (PWUO), and community stakeholders] on the barriers to and needs for opioid prevention, treatment, and recovery services using a phenomenological qualitative design. Purposeful and snowball sampling was used to recruit 95 participants across 12 focus groups which were audio-recorded and transcribed verbatim. A seven-member analysis team …

A Desmosomal Cadherin Controls Multipotent Hair Follicle Stem Cell Quiescence And Orchestrates Regeneration Through Adhesion Signaling, William V. J. Hariton, Katja Schulze, Siavash Rahimi, Taravat Shojaeian, Laurence Feldmeyer, Roman Schwob, Andrew M. Overmiller, Beyza S. Sayar, Luca Borradori, Mỹ G. Mahoney, Arnaud Galichet, Eliane J. Müller

Department of Dermatology and Cutaneous Biology Faculty Papers

Stem cells (SCs) are critical to maintain tissue homeostasis. However, it is currently not known whether signaling through cell junctions protects quiescent epithelial SC reservoirs from depletion during disease-inflicted damage. Using the autoimmune model disease pemphigus vulgaris (PV), this study reveals an unprecedented role for a desmosomal cadherin in governing SC quiescence and regeneration through adhesion signaling in the multipotent mouse hair follicle compartment known as the bulge. Autoantibody-mediated, mechanical uncoupling of desmoglein (Dsg) 3 transadhesion activates quiescent bulge SC which lose their multipotency and stemness, become actively cycling, and finally delaminate from their epithelial niche. This then initiates a …

Molecular Species Delimitation Of Marine Trematodes Over Wide Geographical Ranges: Schikhobalotrema Spp. (Digenea: Haplosplanchnidae) In Needlefishes (Belonidae) From The Pacific Ocean And Gulf Of Mexico, Gerardo Pérez-Ponce De León, Brenda Solórzano-García, Daniel C. Huston, Berenit Mendoza-Garfias, Jhonatan Cabañas-Granillo, Scott C. Cutmore, Thomas H. Cribb

Harold W. Manter Laboratory of Parasitology: Library Materials

Geographical distribution plays a major role in our understanding of marine biodiversity. Some marine fish trematodes have been shown to have highly restricted geographical distributions, while some are known to occur over very wide ranges; however, very few of these wide distributions have been demonstrated genetically. Here, we analyse species of the genus Schikhobalotrema (Haplosplanchnidae) parasitizing beloniforms from the tropical west Pacific, the eastern Pacific and the Gulf of Mexico (GoM). We test the boundaries of these trematodes by integrating molecular and morphological data, host association, habitat of the hosts and geographical distribution, following a recently proposed and standardized delineation …

Twelve Wallace Myths, Charles H. Smith

Faculty/Staff Personal Papers

Alfred Russel Wallace’s (1823-1913) bicentennial year is a good time to take stock. In this presentation I discuss twelve Wallace-related issues that I feel have been poorly taken up. These range from the biological to the biographical, including subjects such as social criticism, human evolution, autobiographical memory, natural selection, national affinities, spiritualism, and wokeism.

Towards A Virtual Reality Visualization Of Hand-Object Interactions To Support Remote Physical Therapy, Trudi Di Qi, Louanne Boyd, Scott Fitzpatrick, Meghna Raswan, Franceli L. Cibrian

Engineering Faculty Articles and Research

Improving object manipulation skills through hand-object interaction exercises is crucial for rehabilitation. Despite limited healthcare resources, physical therapists propose remote exercise routines followed up by remote monitoring. However, remote motor skills assessment remains challenging due to the lack of effective motion visualizations. Therefore, exploring innovative ways of visualization is crucial, and virtual reality (VR) has shown the potential to address this limitation. However, it is unclear how VR visualization can represent understandable hand-object interactions. To address this gap, in this paper, we present VRMoVi, a VR visualization system that incorporates multiple levels of 3D visualization layers to depict movements. In …

The Distribution And Characterisation Of Microplastics In Air, Surface Water And Sediment Within A Major River System, Imogen E. Napper, Anju Baroth, Aaron C. Barrett, Sunanda Bhola, Gawsia W. Chowdhury, Bede F.R. Davies, Emily M. Duncan, Sumit Kumar, Sarah E. Nelms, Md Nazmul Hasan Niloy, Bushra Nishat, Taylor Maddalene, Natalie Smith, Richard C. Thompson, Heather Koldewey

School of Biological and Marine Sciences

Rivers are key pathways for the transfer of microplastics (MP) to marine environments. However, there are considerable uncertainties about the amount of microplastics transported by rivers to the ocean; this results in inaccuracies in our understanding of microplastic quantity and transport by freshwater systems. Additionally, it has been suggested that rivers may represent long-term sinks, with microplastics accumulating in sediment due to their high density or other biological, chemical, and physical factors. The atmosphere is also an important pathway by which airborne microplastics may enter aquatic habitats. Here, we compare for first time microplastics type and concentration in these key …

Mechanisms Of Ferroptosis And Targeted Therapeutic Approaches In Lymphoma, Tiantian Yu, Zijun Y Xu-Monette, Li Yu, Yong Li, Ken H Young

Faculty, Staff and Students Publications

Lymphoma is the sixth most common type of cancer worldwide. Under the current treatment standards, patients with lymphoma often fail to respond to treatment or relapse early and require further therapy. Hence, novel therapeutic strategies need to be explored and our understanding of the molecular underpinnings of lymphomas should be expanded. Ferroptosis, a non-apoptotic regulated cell death, is characterized by increased reactive oxygen species and lipid peroxidation due to metabolic dysfunction. Excessive or lack of ferroptosis has been implicated in tumor development. Current preclinical evidences suggest that ferroptosis participates in tumorigenesis, progression, and drug resistance of lymphoma, identifying a potential …

Make A Difference: Choose Artificial Reefs Over Natural Reefs To Compensate For The Environmental Impacts Of Dive Tourism, Louise B. Firth, Mark Farnworth, Keiron P.P. Fraser, Abigail Mcquatters-Gollop

School of Biological and Marine Sciences

In the marine environment, natural reef habitats are amongst the most threatened by human activities. Although reef-based ecotourism can benefit local economies, dive tourism can damage sensitive habitats. One solution to managing conflicts between the economic value of diving and its ecological threats is the deployment of artificial reefs near popular dive sites. We surveyed recreational divers to assess divers' use, preference, and perceptions of diving artificial versus natural sites. We found that more divers prefer to dive in natural than artificial habitats, with associated biodiversity the most popular reason for preferring natural habitats, and appreciating shipwrecks the most popular …

Dual Consciousness: What Psychology And Counseling Theories Can Teach And Learn Regarding Identity And The Role-Playing Game Experience, Elektra Diakolambrianou, Sarah L. Bowman

Journal of Roleplaying Studies and STEAM

Many psychologists, therapists, and educators have emphasized the practice of play, especially with enacted roles, as a site for learning and therapeutic growth. This article weaves together a plethora of theories from psychology, Counseling, and role-playing game studies in an effort to understand the nature of enacted roles, their relationship to identity, and their transformative potential. Challenging the notion that identity is a fixed, stable monolith, the article synthesizes four overall approaches to theorizing the nature of identity drawn from various theories: identity as a social construct, narrative identity, identity as psychodynamic, and identities as parts of a whole. The …