Digital Commons Network^™

Droid: Dose-Ranging Approach To Optimizing Dose In Oncology Drug Development, Beibei Guo, Ying Yuan

Faculty, Staff and Student Publications

In the era of targeted therapy, there has been increasing concern about the development of oncology drugs based on the "more is better" paradigm, developed decades ago for chemotherapy. Recently, the US Food and Drug Administration (FDA) initiated Project Optimus to reform the dose optimization and dose selection paradigm in oncology drug development. To accommodate this paradigm shifting, we propose a dose-ranging approach to optimizing dose (DROID) for oncology trials with targeted drugs. DROID leverages the well-established dose-ranging study framework, which has been routinely used to develop non-oncology drugs for decades, and bridges it with established oncology dose-finding designs to …

Radiation-Induced Innate Neutrophil Response In Tumor Is Mediated By The Cxcls/Cxcr2 Axis, Faya Zhang, Oscar Mulvaney, Erica Salcedo, Subrata Manna, James Z Zhu, Tao Wang, Chul Ahn, Laurentiu M Pop, Raquibul Hannan

Faculty, Staff and Student Publications

The early events that lead to the inflammatory and immune-modulatory effects of radiation therapy (RT) in the tumor microenvironment (TME) after its DNA damage response activating the innate DNA-sensing pathways are largely unknown. Neutrophilic infiltration into the TME in response to RT is an early innate inflammatory response that occurs within 24-48 h. Using two different syngeneic murine tumor models (RM-9 and MC-38), we demonstrated that CXCR2 blockade significantly reduced RT-induced neutrophilic infiltration. CXCR2 blockade showed the same effects on RT-induced tumor inhibition and host survival as direct neutrophil depletion. Neutrophils highly and preferentially expressed CXCR2 compared to other immune …

Electronic Nicotine Delivery Systems Use And Periodontal Health—Findings From The Population Assessment Of Tobacco And Health Study, Amir Mohajeri, Martin S. Lipsky, Rachana Hegde, Jody Chiang, Man Hung

Institute on Aging Publications

Background: Electronic nicotine delivery systems (ENDSs) are rapidly increasing in the U.S., however, information about their long-term risks and benefits remains limited. This study examined the relationship between ENDS use and periodontal health among U.S. adults. (2) Methods: Data came from 33,822 adults who participated in the 2016–2018 wave of the Population Assessment of Tobacco and Health (PATH) study. Inclusion criteria were adults without a history of cigarette smoking or diabetes. Logistic regression analysis was performed to estimate the associations between ENDS use and a history of periodontal disease, with multivariable logistic regression adjusting for factors associated with poor oral …

Effects Of Perforations On Internal Cathodic Protection And Recruitment Of Marine Organisms To Steel Pipes, Alexander John Paluzzi

Theses and Dissertations

Steel monopile support structures for offshore wind turbines require protection from corrosion on their external and internal surfaces. Cathodic protection (CP) works effectively to protect the external surfaces of monopiles, but internally, byproducts from aluminum sacrificial anode CP (SACP) and impressed current CP (ICCP) induce acidification that accelerates steel corrosion. This project investigated the effects of perforations on the performance of aluminum SACP and ICCP when used inside of steel pipes. Additionally, marine growth on the external and internal surfaces of the pipes was assessed to determine if CP byproducts affect marine organism development.

Two sealed and two perforated steel …

Preparing New Ceramic Membranes From Syrian Zeolite Coated With Silver Nanoparticles To Treatment Wells Water, Abdulrazzaq Hammal

Baghdad Science Journal

As a result of the exacerbation of the problem of water pollution, research was directed towards studying the treatment using ceramic membranes, which proved to be highly effective in treating all water sources. The research aims to study the possibility of preparing a new type of ceramic membranes from Syrian zeolite that was not previously used in this field. In this research, ceramic membranes were prepared from Syrian raw zeolite in several stages. Zeolite sample was characterized, grinded, mixed with boric acid, pressed to form desks, treated thermally according to experiment program, finally coated with silver nanoparticles. Specifications of prepared …

Nano Composites Of Pam Reinforced With Al2o3, Balqees M. Al-Dabbag, Hanaa Jawad Kadhim

Baghdad Science Journal

The aim of this investigation is to determine how different weight percentages of alumina nanoparticles, including 0.02, 0.04, and 0.06 percent wt, affect the physical characteristics of Poly Acrylamide (PAAM). Using a hot plate magnetic stirrer, 10 g of poly acrylamide powder was dissolved in 90 g of di-ionized distillate water for 4 hours to produce PAAM with a concentration of 0.11 g/ml. Four sections of the resulting solution, each with a volume of 20 ml, were created. Each solution was added independently with alumina nanoparticles in different ratios 0.0, 0.02, 0.04, and 0.06 to create four nano fluid solutions …

Estimating The Chemical Composition Of Secondary Compounds Of Iraqi Wild Agaricus Bellaniae Characterized Morphologically And Genetically, Ziena M. Abdul-Qader, Rukiabaa A. Chechan, Sudad K.M. Al-Taweel

Baghdad Science Journal

This study, which is considered the first of its kind in the world and the Arab homeland, was carried out in the laboratory of mushroom production belonging to the Medicinal Plant Unit/ College Of Agricultural Engineering Sciences/ University of Baghdad during the period from July 21, 2016, to December 30, 2018, aiming to isolate and purify the mycelium of the wild isolation in addition to the genetic and morphological identification of the mushroom Agaricus bellaniae. The obtained pure isolation was tagged in the American National Center for Biotechnology Information (NCBI) with symbol MF987843.1, thus Iraq would be the second country …

Control Pepper Fusarium Wilting By Biocontrol Agent Trichoderma Harzianum And Chelated Iron Fe-Eddha, Ali Nasser Ali Al-Aamel, Bushra Subair Abdulsada Al-Maliky

Baghdad Science Journal

Sweet pepper (Capsicum annuum L.) is an economically important vegetable crop. Wilt disease caused by Fusarium oxysporum f. sp. capsici is a specific pathogen that affects the pepper. Four isolates of F. oxysporum f. sp. capsici Fo3, Fo6, Fo7 and Fo8 were obtained from diseased pepper plants that were collected from different pepper fields in Baghdad. Fo6 isolate that has high pathogenicity to pepper seeds, Trichoderma harzianum (Th) was tested in vitro against F. oxysporum f. sp. capsici showed a high inhibition rate for the isolate Fo6, the concentration of chelated iron Fe-EDDHA 0.5% reduced the radial growth of Fo6 …

About Semi-Parametric Methodology For Fuzzy Quantile Regression Model Estimation: A Review, Elaf Baha Alwan, Omar Abdulmohsin Ali

Journal of Economics and Administrative Sciences

In this paper, previous studies about Fuzzy regression had been presented. The fuzzy regression is a generalization of the traditional regression model that formulates a fuzzy environment's relationship to independent and dependent variables. All this can be introduced by non-parametric model, as well as a semi-parametric model. Moreover, results obtained from the previous studies and their conclusions were put forward in this context. So, we suggest a novel method of estimation via new weights instead of the old weights and introduce another suggestion based on artificial neural networks.

The Role Of Quality Of Work Life In Reinforcing Core Competencies: A Descriptive And Analytical Research In The Ministry Of Health, Ali Adnan Hasan, Haider Fadhel Kadhem, Alaulddin B. Jawad

Journal of Economics and Administrative Sciences

The research aims to diagnose the shortcomings and weaknesses in applying the dimensions of the quality of work life and the extent of their impact on employees’ attitudes and behaviors, and thus their relationship to enhancing their core competencies. The scientific value of the research stems from highlighting the importance of the dimensions of the quality of professional life in improving the productive efficiency of workers in the public sector and raising the level of organizational performance. Because the quality of working life plays an important role in enhancing the core competencies of employees in the public sector, it can …

Taxonomic And Morphological Studies On The Genus Chrotogonus Serville, 1838 (Pyrgomorphidae: Orthoptera) From Pakistan, With Reference To Their Habitats, Samiullah Soomro, Riffat Sultana

Baghdad Science Journal

Species of genus Chrotogonus (surface grasshoppers) are phytophagous and damaging to various economical important plants in their seedling stages. In order to know the biodiversity of surface grasshoppers, the detailed study has been conducted from four provinces of Pakistan. During this study, biodiversity, taxonomy, diagnosis, morphometric analysis, habitat, global distribution, and remarks of each species have been described. Total of 826 specimens were collected and sorted out into three species and three subspecies: C. (Chrotogonus) homalodemus homalodemus (Blanchard, 1836), C. (Chrotogonus) homalodemus (Blanchard, 1836), C. (Chrotogonus) trachypterus trachypterus (Blanchard, 1836), C. (Chrotogonus) trachypterus robertsi Kirby, 1914, C. (Chrotogonus) trachypterus (Blanchard, …

Corrosion Inhibition Efficiency Investigation Of Yttrium Oxide Nanoparticles Coated On Carbon Steel Alloy, Maha J. Hassin, Taghried A. Salman

Baghdad Science Journal

Metal oxide nanoparticles demonstrate uniqueness in various technical applications due to their suitable physiochemical properties. In particular, yttrium oxide nanoparticle(Y2O3NPs) is familiar for technical applications because of its higher dielectric constant and thermal stability. It is widely used as a host material for a variety of rare-earth dopants, biological imaging, and photodynamic therapies. In this investigation, yttrium oxide nanoparticles (Y2O3NPs) was used as an ecofriendly corrosion inhibitor through the use of scanning electron microscopy (SEM), Fourier transforms infrared spectroscopy (FT-IR), UV-Visible spectroscopy, X-ray diffraction (XRD), and energy dispersive X-ray spectroscopy(EDX), the physico-chemical characterization of Y2O3NPs was examined. The primary characteristic …

Ni2+, Pt4+, Pd2+, And Mn2+ Metal Ions Complexes With Azo Derived From Quinolin-2-Ol And 3-Amino-N-(5-Methylisoxazol-3-Yl) Benzenesulfonamide: Synthesis, Characterization, Thermal Study ,And Antioxidant Activity, Adhraa Ghazi Abdulrazzaq, Abbas Ali Salih Al-Hamdani

Baghdad Science Journal

Diazotization reaction between quinolin-2-ol and (2-chloro-1-(4-(N-(5-methylisoxazol-3-yl)sulfamoyl)phenyl)-2l4-diazyn-1-ium was carried out resulting in ligand-HL, this in turn reacted with the next metal ions (Ni2+, Pt4+, Pd2+, and Mn2+) forming stable complexes with unique geometries such as (tetrahedral for both Ni2+ and Mn2+, octahedral for Pt4+ and square planer for Pd2+ ). The creation of such complexes was detected by employing spectroscopic means involving ultraviolet-visible which proved the obtained geometries, fourier transfer proved the formation of azo group and the coordination with metal ion through it. Pyrolysis (TGA & DSC) studies proved the coordination of water residues with metal ions inside the coordination …

Removing Toxic Dyes From Aqueous Medium By Trichoderma-Graphain Oxide Aerogel, Shaimaa Satae M Ali, Rana Hadi Hameed Al-Shammari, Ayad M.J. Al-Mamoori

Baghdad Science Journal

Toxic dyes are commonly discharged into waste waters and dyes are extensively used in the textile industry so it is necessary to find out efficient and eco-friendly method for treating waste waters resulting from industrial effluences. To achieve this aim the fungus Trichoderma sp. is employed into two lines: first line was self – immobilized fungal pellets in (Czapek – Dox medium) to adsorbs two dyes crystal violet, congo red by concentrations 0.01, 0.02, 0.03, 0.04, 0.05, 0.06 mg/L to both dyes, PH 2, room temperature with shaker in ( hrs.2,hrs.4,hrs.24) , by Uv- Visible spectrum . the removal efficiency …

Disentangling Transformer Language Models As Superposed Topic Models, Jia Peng Lim, Hady Wirawan Lauw

Research Collection School Of Computing and Information Systems

Topic Modelling is an established research area where the quality of a given topic is measured using coherence metrics. Often, we infer topics from Neural Topic Models (NTM) by interpreting their decoder weights, consisting of top-activated words projected from individual neurons. Transformer-based Language Models (TLM) similarly consist of decoder weights. However, due to its hypothesised superposition properties, the final logits originating from the residual path are considered uninterpretable. Therefore, we posit that we can interpret TLM as superposed NTM by proposing a novel weight-based, model-agnostic and corpus-agnostic approach to search and disentangle decoder-only TLM, potentially mapping individual neurons to multiple …

A Reliable And Secure Mobile Cyber-Physical Digital Microfluidic Biochip For Intelligent Healthcare, Yinan Yao, Decheng Qiu, Huangda Liu, Zhongliao Yang, Ximeng Liu, Yang Yang, Chen Dong

Research Collection School Of Computing and Information Systems

Digital microfluidic, as an emerging and potential technology, diversifies the biochemical applications platform, such as protein dilution sewage detection. At present, a vast majority of universal cyberphysical digital microfluidic biochips (DMFBs) transmit data through wires via personal computers and microcontrollers (like Arduino), consequently, susceptible to various security threats and with the popularity of wireless devices, losing competitiveness gradually. On the premise that security be ensured first and foremost, calls for wireless portable, safe, and economical DMFBs are imperative to expand their application fields, engage more users, and cater to the trend of future wireless communication. To this end, a new …

Depwignn: A Depth-Wise Graph Neural Network For Multi-Hop Spatial Reasoning In Text, Shuaiyi Li, Yang Deng, Wai Lam

Research Collection School Of Computing and Information Systems

Spatial reasoning in text plays a crucial role in various real-world applications. Existing approaches for spatial reasoning typically infer spatial relations from pure text, which overlook the gap between natural language and symbolic structures. Graph neural networks (GNNs) have showcased exceptional proficiency in inducing and aggregating symbolic structures. However, classical GNNs face challenges in handling multi-hop spatial reasoning due to the over-smoothing issue, i.e., the performance decreases substantially as the number of graph layers increases. To cope with these challenges, we propose a novel Depth-Wise Graph Neural Network (DepWiGNN). Specifically, we design a novel node memory scheme and aggregate the …

The Effect Of Maternal Obesity On The Regulation Of Gene Expression And Cell Fate During Embryonic Cortical Neurogenesis, Thilina Thejinda Alawathugoda

Dissertations

Neurodevelopmental disorders have their roots in multifaceted origins that manifest during the earliest stages of embryonic growth, often linked to sophisticated gene regulation dynamics. A perturbed metabolic environment, specifically owing to maternal obesity, can lead to dyslipidemia, subsequently threatening the optimal development of the embryonic central nervous system. Growing evidence suggests that such metabolic irregularities during pregnancy can alter neurogenesis pathways, thus predisposing the developing fetus to neurodevelopmental disorders. One of the primary avenues through which these disruptions may occur is through alterations in histone modifications resulting from fluctuations in the expression of histone modifying enzymes or the availability of …

Thermodynamics And Kinetics Analyses Of Clc-Ec1 Dimerization Reaction In Lipid Bilayers, Taeho Lee

Arts & Sciences Graduate Student Theses and Dissertations

The efforts of this thesis are directed towards understanding the thermodynamics and kinetics underlying the dimerization reaction of a chloride/proton antiporter membrane protein, CLC-ec1, in lipid membranes. Due to the inherent challenges of working with membrane proteins, thermodynamic and kinetic information for the protein association reactions in membranes has been historically limited. The research presented in this thesis demonstrates the technological advancements for these measurements in a model membrane protein system, thereby setting an important milestone for the field. Since CLC-ec1 dimerizes via a greasy, membrane embedded binding interface, the physical driving forces involved in this reaction were unknown. It …

A Study Of Policies And Responses To Chronically Absent Students In Illinois High Schools In The Four Southern Most Regions Of The Illinois Associaiton Of School Administrators, Charles Shain Crank

Dissertations

No abstract

Utilizing The Genetic Potentials Of Traditional Rice Varieties And Conserving Rice Biodiversity With System Of Rice Intensification Management, Yheni Dwiningsih

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

The genetic potentials of rice cultivars will need to be expressed to their fullest if global rice production is to be expanded enough by 2050 to meet the increased demand of the expanding population while the availability of land and water per capita dwindles. New and ‘improved’ rice varieties have contributed greatly to increased production over the past 50 years, but the rate of rice yield increase based on genetic changes has declined in recent decades compared with the early years of the Green Revolution. In fact, many rice consumers continue to prefer to consume ‘traditional’ rice varieties (referred to …

Uncertainty In Streamflow Measurements Significantly Impacts Estimates Of Downstream Nitrate Export, Shannon L. Speir, C. Nathan Jones, Arial J. Shogren, Carla L. Atkinson

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Across watershed science, two key variables emerge–streamflow and solute concentration–which serve as the basis for efforts ranging from basic watershed biogeochemistry research to policy decisions surrounding watershed management. However, we rarely account for how error in discharge (Q) impacts estimates of downstream nutrient loading. Here, we examined the impact of uncertainty in streamflow measurements on estimates of downstream nitrate export using publicly available data from the U.S. Geological Survey (USGS). We characterized how uncertainty in stage-discharge relationships impacts annual flux estimates across 70 USGS gages. Our results indicate the interquartile range of relative error in Q was 33% across these …

Alpha Particle-Emitting Radiopharmaceuticals As Cancer Therapy: Biological Basis, Current Status, And Future Outlook For Therapeutics Discovery, Ryan P Coll, Scott J Bright, David K J Martinus, Dimitra K Georgiou, Gabriel O Sawakuchi, H Charles Manning

Faculty, Staff and Student Publications

Critical advances in radionuclide therapy have led to encouraging new options for cancer treatment through the pairing of clinically useful radiation-emitting radionuclides and innovative pharmaceutical discovery. Of the various subatomic particles used in therapeutic radiopharmaceuticals, alpha (α) particles show great promise owing to their relatively large size, delivered energy, finite pathlength, and resulting ionization density. This review discusses the therapeutic benefits of α-emitting radiopharmaceuticals and their pairing with appropriate diagnostics, resulting in innovative "theranostic" platforms. Herein, the current landscape of α particle-emitting radionuclides is described with an emphasis on their use in theranostic development for cancer treatment. Commonly studied radionuclides …

Structural Health Monitoring: The Use Of Acoustic Emission To Optimize The Fdm Additive Manufacturing Process, Ethan Phillips

All Theses

Fused Deposition Modeling (FDM) has gained widespread popularity as an affordable, versatile, and user-friendly additive manufacturing technique. However, ensuring consistent and high-quality prints remains a significant challenge. This study investigated the potential use of Nondestructive Evaluation (NDE) in the form of Acoustic Emission (AE) to optimize the FDM 3D printing process, including filament defects and the selection of print parameters. AE monitoring involves the detection and analysis of acoustic waves generated during the printing post-process, providing valuable insights into the dynamic behavior of a specimen with respect to the selected print parameters and integrity of the system. Specific acoustic patterns …

Estradiol Mediates Colonic Epithelial Protection In Aged Mice After Stroke And Is Associated With Shifts In The Gut Microbiome, Juneyoung Lee, Pedram Peesh, Victoria Quaicoe, Chunfeng Tan, Anik Banerjee, Patrick Mooz, Bhanu P Ganesh, Joseph Petrosino, Robert M Bryan, Louise D Mccullough, Venugopal Reddy Venna

Faculty, Staff and Student Publications

The gut is a major source of bacteria and antigens that contribute to neuroinflammation after brain injury. Colonic epithelial cells (ECs) are responsible for secreting major cellular components of the innate defense system, including antimicrobial proteins (AMP) and mucins. These cells serve as a critical regulator of gut barrier function and maintain host-microbe homeostasis. In this study, we determined post-stroke host defense responses at the colonic epithelial surface in mice. We then tested if the enhancement of these epithelial protective mechanisms is beneficial in young and aged mice after stroke. AMPs were significantly increased in the colonic ECs of young …

Sex Differences In Fatigability And Recovery Following A 5 Km Running Time Trial In Recreationally Active Adults, Maria Solleiro Pons, Sandra K. Hunter, Paul Ansdell

Exercise Science Faculty Research and Publications

Females demonstrate greater fatigue resistance compared to males in tasks ranging from single-limb contractions to whole-body exercise, including running. Many of the studies investigating sex differences in fatigability following running, however, occur after long duration, low-intensity tasks and it is unknown whether there is a sex difference in fatigability following high-intensity running. This study compared fatigability and recovery following a 5 km running time trial in young males and females. Sixteen recreationally active participants (8 males, 8 females, age: 23 ± 4 years) completed a familiarisation and experimental trial. Knee-extensor maximal voluntary contractions (MVCs) were performed before and up to …

Cerebellar Eeg Source Localization Reveals Age-Related Compensatory Activity Moderated By Genetic Risk For Alzheimer’S Disease, Elizabeth Paitel, Kristy A. Nielson

Psychology Faculty Research and Publications

The apolipoprotein-E (APOE) ε4 allele is the greatest genetic risk factor for late-onset Alzheimer's disease (AD), but alone it is not sufficiently predictive. Because neuropathological changes associated with AD begin decades before cognitive symptoms, neuroimaging of healthy, cognitively intact ε4 carriers (ε4+) may enable early characterization of patterns associated with risk for future decline. Research in the cerebral cortex highlights a period of compensatory recruitment in elders and ε4+, which serves to maintain cognitive functioning. Yet, AD-related changes may occur even earlier in the cerebellum. Advances in electroencephalography (EEG) source localization now allow effective modeling of cerebellar activity. Importantly, healthy …

Neuroimaging-Based Classification Of Ptsd Using Data-Driven Computational Approaches: A Multisite Big Data Study From The Enigma-Pgc Ptsd Consortium, Jacklynn M. Fitzgerald

Psychology Faculty Research and Publications

Background

Recent advances in data-driven computational approaches have been helpful in devising tools to objectively diagnose psychiatric disorders. However, current machine learning studies limited to small homogeneous samples, different methodologies, and different imaging collection protocols, limit the ability to directly compare and generalize their results. Here we aimed to classify individuals with PTSD versus controls and assess the generalizability using a large heterogeneous brain datasets from the ENIGMA-PGC PTSD Working group.

Methods

We analyzed brain MRI data from 3,477 structural-MRI; 2,495 resting state-fMRI; and 1,952 diffusion-MRI. First, we identified the brain features that best distinguish individuals with PTSD from controls …

Polluting The Senses: The Impact Of Noise And Light Pollution On Fledgling Movement And Evolution Within The Avian Eye, Margaret C. Mackinlay

Master's Theses

There is more human-generated noise and light today than ever before, a trend tied to ongoing urbanization and with reverberating impacts on a wide range of organisms. While research on these impacts is mounting and particularly plentiful when it comes to birds, there is still much to explore within its effects on avian behavior, fitness, and evolution. In chapter 1, we investigated how fledgling movement is influenced by noise and light pollution. While adult birds have well-documented species-specific responses to these stimuli, fledglings are sorely understudied in this context. We experimentally manipulated light levels and took advantage of an existing …

An Ecological Assessment Of An Endangered Lichen From Central California: Sulcaria Isidiifera, The Splitting Yarn Lichen, Elijah C. Balderas

Master's Theses

Lichens are an underrepresented group of organisms when it comes to both research and conservation efforts. At the same time, lichens face increasing threats from anthropogenic sources including wildfires, climate change and urbanization. With this thesis, I seek to ascertain and publish ecological data on a critically endangered lichen to inform future conservation designations and efforts to preserve and protect the species in perpetuity.

In Chapter 1, I provide an ecological overview of the known range of Sulcaria isidiifera and assess the status of Sulcaria isidiifera via a population count. Sulcaria isidiifera occurs in maritime chaparral habitat in the Los …