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Hand-Use Preferences For Reaching And Object Exploration In Children With Impaired Upper Extremity Functioning: The Role Of Environmental Affordances, Iryna Babik, Michele A. Lobo

Psychological Sciences Faculty Publications and Presentations

Infants and young children with weakened or impaired upper extremity functioning often develop a strong hand-use “preference” for reaching and object manipulation. While “preferring” their stronger hand, they often partially or completely ignore their “non-preferred” hand. Such manual lateralization might impede complex object exploration, which would negatively affect children’s cognitive development. The question is whether environmental affordances would significantly affect children’s manifested hand-use “preferences” by promoting the use of the “non-preferred” hand. The current sample included 17 children (5 males; 13.9 ± 8.7 months at baseline) with arthrogryposis multiplex congenita (arthrogryposis). The reaching and object exploration of the children were …

The Effect Of Pesticide Spray Season And Residential Proximity To Agriculture On Glyphosate Exposure Among Pregnant People In Southern Idaho, 2021, Cynthia L. Curl, Carly Hyland, Meredith Spivak, Lianne Sheppard, Bruce Lanphear, Michael N. Antoniou, Maria Ospina, Antonia M. Calafat

Public and Population Health Faculty Publications and Presentations

Background: Glyphosate is one of the most heavily used pesticides in the world, but little is known about sources of glyphosate exposure in pregnant people living in agricultural regions.

Objective: Our objective was to evaluate glyphosate exposure during pregnancy in relation to residential proximity to agriculture as well as agricultural spray season.

Methods: We quantified glyphosate concentrations in 453 urine samples collected biweekly from a cohort of 40 pregnant people in southern Idaho from February through December 2021. We estimated each participant’s glyphosate exposure as the geometric mean (GM) of glyphosate concentrations measured in all samples (average n = 11 …

Ionically Crosslinked Cellulose Nanocrystals By Metal Nitrates For The Preparation Of Stable Emulsions With Tunable Interface Properties, Joseph Batta-Mpouma, Gurshagan Kandhola, Jin-Woo Kim

Materials Science and Engineering Faculty Publications and Presentations

Biologically extracted cellulose nanocrystals (CNCs) are rod-like and amphiphilic materials with surface-exposed (hydrophilic sites) and hidden (hydrophobic sites) hydroxyl groups. These physicochemical characteristics make CNCs suitable for use as emulsifying agents to stabilize emulsions. Stable oil-in-water emulsions, using sulfated (i.e., – SO₃−) CNCs that were ionically crosslinked with alkaline-earth (i.e., Mg ²⁺) or transition-d-block (i.e., Zn ²⁺) metal cations, were developed without the use of any synthetic surfactants or prior functionalization of pure CNCs with hydrophobic molecules. Various emulsion surface properties such as interfacial tension, surface charge, surface chemistry, as well as rheology were characterized. Ionically …

Exploring Artist Residencies For Academic Libraries, Jenne M. Klotz

Libraries

This white paper describes the results of a research leave that explored artist residencies and considered their potential in academic libraries.

Developing Resilience In The School Setting: A Response To Trauma, Michelle Nutter

All-Inclusive List of Electronic Theses and Dissertations

Lasting effects of childhood trauma manifest themselves in a variety of problem behaviors witnessed in classrooms across the nation. School staff would benefit from background knowledge to understand students who have experienced trauma and interventions to respond appropriately and positively to behaviors. As a school leader, the purpose of this cross-case qualitative design was twofold. First, I hoped to understand the perceptions of school staff members regarding trauma-informed interventions in elementary public schools. Second, this study explored the infrastructure of select schools that enable principals and staff members to view its students through a trauma lens. Literature on successful interventions …

Inference Of Admixture Origins In Indigenous African Cattle., Kwondo Kim, Donghee Kim, Olivier Hanotte, Charles Lee, Heebal Kim, Choongwon Jeong

Faculty Research 2023

Present-day African cattle retain a unique genetic profile composed of a mixture of the Bos taurus and Bos indicus populations introduced into the continent at different time periods. However, details of the admixture history and the exact origins of the source populations remain obscure. Here, we infer the source of admixture in the earliest domestic cattle in Africa, African taurine. We detect a significant contribution (up to ∼20%) from a basal taurine lineage, which might represent the now-extinct African aurochs. In addition, we show that the indicine ancestry of African cattle, although most closely related to so-far sampled North Indian …

Systematic Evaluation Of Aml-Associated Antigens Identifies Anti-U5 Snrnp200 Therapeutic Antibodies For The Treatment Of Acute Myeloid Leukemia., Katherine Knorr, Jahan Rahman, Caroline Erickson, Eric Wang, Mara Monetti, Zhuoning Li, Juliana Ortiz-Pacheco, Andrew Jones, Sydney X Lu, Robert F Stanley, Maria Baez, Nina Fox, Cynthia Castro, Alessandra E Marino, Caroline Jiang, Alex Penson, Simon J Hogg, Xiaoli Mi, Hideaki Nakajima, Hiroyoshi Kunimoto, Koutarou Nishimura, Daichi Inoue, Benjamin Greenbaum, David Knorr, Jeffrey Ravetch, Omar Abdel-Wahab

Faculty Research 2023

Despite recent advances in the treatment of acute myeloid leukemia (AML), there has been limited success in targeting surface antigens in AML, in part due to shared expression across malignant and normal cells. Here, high-density immunophenotyping of AML coupled with proteogenomics identified unique expression of a variety of antigens, including the RNA helicase U5 snRNP200, on the surface of AML cells but not on normal hematopoietic precursors and skewed Fc receptor distribution in the AML immune microenvironment. Cell membrane localization of U5 snRNP200 was linked to surface expression of the Fcγ receptor IIIA (FcγIIIA, also known as CD32A) and correlated …

Candidate Signatures Of Positive Selection For Environmental Adaptation In Indigenous African Cattle: A Review., Sumaya Kambal, Abdulfatai Tijjani, Sabah A E Ibrahim, Mohamed-Khair A Ahmed, Joram M Mwacharo, Olivier Hanotte

Faculty Research 2023

Environmental adaptation traits of indigenous African cattle are increasingly being investigated to respond to the need for sustainable livestock production in the context of unpredictable climatic changes. Several studies have highlighted genomic regions under positive selection probably associated with adaptation to environmental challenges (e.g. heat stress, trypanosomiasis, tick and tick-borne diseases). However, little attention has focused on pinpointing the candidate causative variant(s) controlling the traits. This review compiled information from 22 studies on signatures of positive selection in indigenous African cattle breeds to identify regions under positive selection. We highlight some key candidate genome regions and genes of relevance to …

Discovery Of Ferm Domain Protein-Protein Interaction Inhibitors For Msn And Cd44 As A Potential Therapeutic Approach For Alzheimer's Disease., Yuhong Du, William J Bradshaw, Tina M Leisner, Joel K Annor-Gyamfi, Kun Qian, Frances M Bashore, Arunima Sikdar, Felix O Nwogbo, Andrey A Ivanov, Stephen V Frye, Opher Gileadi, Paul E Brennan, Allan I Levey, The Emory-Sage-Sgc Treat-Ad Center, Alison D Axtman, Kenneth H Pearce, Haian Fu, Vittorio L Katis

Faculty Research 2023

Proteomic studies have identified moesin (MSN), a protein containing a four-point-one, ezrin, radixin, moesin (FERM) domain, and the receptor CD44 as hub proteins found within a coexpression module strongly linked to Alzheimer's disease (AD) traits and microglia. These proteins are more abundant in Alzheimer's patient brains, and their levels are positively correlated with cognitive decline, amyloid plaque deposition, and neurofibrillary tangle burden. The MSN FERM domain interacts with the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP

Autonomy In The Spaces: Teacher Autonomy, Scripted Lessons, And The Changing Role Of Teachers, Madhu Narayanan, A. L. Shields, T. J. Delhagen

Educational Leadership and Policy Faculty Publications and Presentations

The work of teachers has historically been highly controlled, but one area teachers have been granted considerable autonomy is in instruction and planning. Teacher autonomy is a complex concept with important implications for both the quality of instruction and teacher persistence in the field. The rise of charter management organizations (CMOs) and the increasing use of scripted lesson plans (SLPs) have introduced new institutional arrangements with unknown impacts on teachers’ perceptions of autonomy. This mixed method study surveyed 155 teachers across all grade levels from CMOs, independent charter, and district schools, on their perceptions of autonomy related to lesson planning. …

Randomized Phase Ii Trial Of Dendritic Cell/Myeloma Fusion Vaccine With Lenalidomide Maintenance After Upfront Autologous Hematopoietic Cell Transplantation For Multiple Myeloma: Bmt Ctn 1401., David J Chung, Nina Shah, Juan Wu, Brent Logan, Lina Bisharat, Natalie Callander, Giulia Cheloni, Kenneth Anderson, Thinle Chodon, Binod Dhakal, Steve Devine, Poorvi Somaiya Dutt, Yvonne Efebera, Nancy Geller, Haider Ghiasuddin, Peiman Hematti, Leona Holmberg, Alan Howard, Bryon Johnson, Dimitra Karagkouni, Hillard M Lazarus, Ehsan Malek, Philip Mccarthy, David Mckenna, Adam Mendizabal, Ajay Nooka, Nikhil Munshi, Lynn O'Donnell, Aaron P Rapoport, Jane Reese, Jacalyn Rosenblatt, Robert Soiffer, Dina Stroopinsky, Lynne Uhl, Ioannis S Vlachos, Edmund K Waller, James W Young, Marcelo C Pasquini, David Avigan

Oncology Articles

PURPOSE: Vaccination with dendritic cell (DC)/multiple myeloma (MM) fusions has been shown to induce the expansion of circulating multiple myeloma-reactive lymphocytes and consolidation of clinical response following autologous hematopoietic cell transplant (auto-HCT).

PATIENTS AND METHODS: In this randomized phase II trial (NCT02728102), we assessed the effect of DC/MM fusion vaccination, GM-CSF, and lenalidomide maintenance as compared with control arms of GM-CSF and lenalidomide or lenalidomide maintenance alone on clinical response rates and induction of multiple myeloma-specific immunity at 1-year posttransplant.

RESULTS: The study enrolled 203 patients, with 140 randomized posttransplantation. Vaccine production was successful in 63 of 68 patients. At …

The Student Movement Volume 108 Issue 10: Vp Or Not Vp?: That Is The Question, Grace No, Lauren Kim, Nick Bishop, Nate Miller, Amelia Stefanescu, Katie Davis, Lily Burke, Kiheon Chung, Robert Zhang, Andrew Francis, Erin Beers, Reagan Westerman, Bella Hamann, Anna Rybachek, Sumin Lee, Alyssa Caruthers

The Student Movement v. 108 (2023-2024)

HUMANS

Interview with Dr. Ponce-Rodas: Change within the Church, Grace No

Dean Spotlight Interview: Alyssa Palmer, Lauren Kim

Maya Sukumaran's Exploration: Unraveling the Neurobiology of Cricket Behavior, Nick Bishop

ARTS & ENTERTAINMENT

AUSO's Vienna Classics Concert, Nate Miller

Discovering the Fine Arts Program, Amelia Stefanescu

What Do Murder and Law School Have in Common?, Amelia Stefanescu

NEWS

AU Abroad, Katie Davis

Context, Changes, Reactions, What's Coming, VP to the Assistant to the President, Lily Burke

Founding of Andrews University, Kiheon Chung

Israel-Gaza Follow Up, Robert Zhang

Second Annual AU Shark Tank Features Intriguing Proposals, Andrew Francis

IDEAS

Coming Out Ministries …

Neutralizing Antibodies Against Ebv Gp42 Show Potent In Vivo Protection And Define Novel Epitopes, Qian Wu, Ling Zhong, Dongmei Wei, Wanlin Zhang, Junping Hong, Yinfeng Kang, Kaiyun Chen, Yang Huang, Qingbing Zheng, Miao Xu, Mu-Sheng Zeng, Yi-Xin Zeng, Ningshao Xia, Qinjian Zhao, Claude Krummenacher, Yixin Chen, Xiao Zhang

College of Science & Mathematics Departmental Research

Epstein-Barr virus (EBV) is the first reported human oncogenic virus and infects more than 95% of the human population worldwide. EBV latent infection in B lymphocytes is essential for viral persistence. Glycoprotein gp42 is an indispensable member of the triggering complex for EBV entry into B cells. The C-type lectin domain (CTLD) of gp42 plays a key role in receptor binding and is the major target of neutralizing antibodies. Here, we isolated two rabbit antibodies, 1A7 and 6G7, targeting gp42 CTLD with potent neutralizing activity against B cell infection. Antibody 6G7 efficiently protects humanized mice from lethal EBV challenge and …

A Low-Power Analog Cell For Implementing Spiking Neural Networks In 65 Nm Cmos, John S. Venker, Luke Vincent, Jeff Dix

Computer Science and Computer Engineering Faculty Publications and Presentations

A Spiking Neural Network (SNN) is realized within a 65 nm CMOS process to demonstrate the feasibility of its constituent cells. Analog hardware neural networks have shown improved energy efficiency in edge computing for real-time-inference applications, such as speech recognition. The proposed network uses a leaky integrate and fire neuron scheme for computation, interleaved with a Spike Timing Dependent Plasticity (STDP) circuit for implementing synaptic-like weights. The low-power, asynchronous analog neurons and synapses are tailored for the VLSI environment needed to effectively make use of hardware SSN systems. To demonstrate functionality, a feedforward Spiking Neural Network composed of two layers, …

2022/2023 Robert E. Kennedy Library Annual Report, Robert E. Kennedy Library

Library Publications and Administrative Reports

This year’s Annual Report is the first “outside” edition of Inside 35 following the closure of the library’s home, Building 35, in June 2023. Kennedy Library remains an active partner in Cal Poly’s curricular and scholarly endeavors from many locations across campus. Learn about our Librarian-Scholars collaborating with students and colleagues on research projects across several disciplines. Discover the comprehensive collection of the works of Joe D’Ambrosio that was generously donated to Special Collections and Archives in 2019. Read an update on the building transformation project and meet the Design-Build Team of Hensel-Phelps and the Miller Hull Partnership. Kennedy Library …

Composition And Function Of The Galapagos Penguin Gut Microbiome Vary With Age, Location, And A Putative Bacterial Pathogen, Sage D. Rohrer, Gustavo Jiménez-Uzcátegui, Patricia G. Parker, Lon M. Chubiz

Biology Department Faculty Works

Microbial colonization plays a direct role in host health. Understanding the ecology of the resident microbial community for a given host species is thus an important step for detecting population vulnerabilities like disease. However, the idea of integrating microbiome research into conservation is still relatively new, and wild birds have received less attention in this field than mammals or domesticated animals. Here we examine the composition and function of the gut microbiome of the endangered Galapagos penguin (Spheniscus mendiculus) with the goals of characterizing the normal microbial community and resistome, identifying likely pathogens, and testing hypotheses of structuring forces for …

Families With Fathers In Minimum Security Prison: A Family Treatment Approach To Treating Families With Fathers In Prison, Alexandria Davis, Madison Schrack

Student Projects

The population of those in prison is increasing, and many of those who are in prison have families. Much research has been done on the effect prison has on prisoners, but not as much has looked at the children and what the effect is of having a parent, specifically their father, who is absent in prison. It is important to understand the possible behaviors, risks, and challenges that children face. This research essay looks at what it is like for children between the ages of 5 and 10 to have a father in minimum security prison while also examining the …

The Alliance Of Genome Resources: Transforming Comparative Genomics., Carol J Bult, Paul W Sternberg

Faculty Research 2023

Comparing genomic and biological characteristics across multiple species is essential to using model systems to investigate the molecular and cellular mechanisms underlying human biology and disease and to translate mechanistic insights from studies in model organisms for clinical applications. Building a scalable knowledge commons platform that supports cross-species comparison of rich, expertly curated knowledge regarding gene function, phenotype, and disease associations available for model organisms and humans is the primary mission of the Alliance of Genome Resources (the Alliance). The Alliance is a consortium of seven model organism knowledgebases (mouse, rat, yeast, nematode, zebrafish, frog, fruit fly) and the Gene …

The Status And Prospects Of Phytoremediation Of Heavy Metals, Aniruddha Acharya, Enrique Perez, Miller Maddox-Mandolini, Hania De La Fuente

Faculty Publications - Biological Sciences

The release of heavy metals into the agricultural soil and waterbodies has been accelerated due to anthropogenic activities. They are not usually required for biological functions thus, their accumulation in biological system poses serious threat to health and environment globally. Phytoremediation offers a safe, inexpensive, and ecologically sustainable technique to clean habitats contaminated with heavy metals. Though several plants have been identified and used as a potential candidate for such phytoremediation, the technique is still at its formative stage and has been mostly confined to laboratory and greenhouses. However, recently several field studies have shown promising results that can propel …

Unpacking The Unconscious: Mortality Awareness And Its Effects On Consumer Engagement In Charitable Campaigns, Lois Warden

Honors Projects in Marketing

This research aims to investigate the interplay between terror management theory, self-other message framing, and psychological distance in influencing individuals’ perceptions, judgements, and behavioral responses, particularly in context of advertisements featuring animals of varying proximity to humans. The purpose of this research is to understand how mortality sensitivity and the categorizations of ‘self’ and ‘other’ impact individuals’ attitudes and intentions towards advertisements featuring animals. The research methodology employed involves experimental designs with manipulated salience of priming conditions (birth or death) and the presentation of animals (monkey as proxy to self and frog as distal to self) to gauge participants attitudes, …

Winter Commencement, 2023, Marshall University

Marshall University Commencement

Program for the One Hundred Eighty-Eighth Commencement of Marshall University, Saturday, December 9 2023 held at the Mountain Health Arena in Huntington, West Virginia.

Mycorrhizal Feedbacks Influence Global Forest Structure And Diversity, Camille S. Delavaux, Joseph A. Lamanna, Jonathan A. Myers, Richard P. Phillips, Salomón Aguilar, David Allen, Alfonso Alonso, Kristina J. Anderson-Teixeira, Matthew E. Baker, Jennifer L. Baltzer, Pulchérie Bissiengou, Mariana Bonfim, Norman A. Bourg, Warren Y. Brockelman, David F.R.P. Burslem, Li Wan Chang, Yang Chen, Jyh Min Chiang, Chengjin Chu, Keith Clay, Susan Cordell, Mary Cortese, Jan Den Ouden, Christopher Dick, Sisira Ediriweera, Erle C. Ellis, Anna Feistner, Amy L. Freestone, Thomas Giambelluca, Christian P. Giardina, Gregory S. Gilbert, Fangliang He, Jan Holík, Robert W. Howe, Walter Huaraca Huasca, Stephen P. Hubbell, Faith Inman, Patrick A. Jansen, Daniel J. Johnson, Kamil Kral, Sabrina E. Russo, Et Al.

Center for Plant Science Innovation: Faculty Publications

One mechanism proposed to explain high species diversity in tropical systems is strong negative conspecific density dependence (CDD), which reduces recruitment of juveniles in proximity to conspecific adult plants. Although evidence shows that plant-specific soil pathogens can drive negative CDD, trees also form key mutualisms with mycorrhizal fungi, which may counteract these effects. Across 43 large-scale forest plots worldwide, we tested whether ectomycorrhizal tree species exhibit weaker negative CDD than arbuscular mycorrhizal tree species. We further tested for conmycorrhizal density dependence (CMDD) to test for benefit from shared mutualists. We found that the strength of CDD varies systematically with mycorrhizal …

Beyond N-Dopants For Organic Semiconductors: Use Of Bibenzo[D]Imidazoles In Uv-Promoted Dehalogenation Reactions Of Organic Halides, Kan Tang, Megan R. Brown, Chad Risko, Melissa K. Gish, Garry Rumbles, Phuc H. Pham, Oana R. Luca, Stephen Barlow, Seth R. Marder

UK CARES Faculty Publications

2,2’-Bis(4-dimethylaminophenyl)- and 2,2'-dicyclohexyl-1,1',3,3'-tetramethyl-2,2',3,3'-tetrahydro-2,2'-bibenzo[d]imidazole ((N-DMBI)2 and (Cyc-DMBI)2) are quite strong reductants with effective potentials of ca. −2 V vs ferrocenium/ferrocene, yet are relatively stable to air due to the coupling of redox and bond-breaking processes. Here, we examine their use in accomplishing electron transfer-induced bond-cleavage reactions, specifically dehalogenations. The dimers reduce halides that have reduction potentials less cathodic than ca. −2 V vs ferrocenium/ferrocene, especially under UV photoexcitation (using a 365 nm LED). In the case of benzyl halides, the products are bibenzyl derivatives, whereas aryl halides are reduced to the corresponding arenes. The potentials of the halides that can be …

Strategic Approach To The Design Of Polymers From Natural Oils, Zoran Petrović, Jian Hong

National Institute for Materials Advancement

Natural oils are a large group of substances with varied compositions and properties. Thus, their utilization in polymers must be carefully planned. Generally, oils are less pure starting materials for the synthesis of polymers compared to petrochemicals, which may have a negative or positive influence on their applications. Designing oils with a desired structure by genetic modifications for a given application is an exciting future development. This chapter [1] tries to systematically analyze the influence of structural factors on the properties and the technologies used to obtain desired products.

Association Between Microbiome And The Development Of Adverse Posttraumatic Neuropsychiatric Sequelae After Traumatic Stress Exposure, Abigail L. Zeamer, Marie Claire Salive, Xinming An, Francesca L. Beaudoin, Stacey L. House, Jennifer S. Stevens, Donglin Zeng, Thomas C. Neylan, Gari D. Clifford, Sarah D. Linnstaedt, Scott L. Rauch, Alan B. Storrow, Christopher Lewandowski, Paul I. Musey, Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Brittany E. Punches, Robert A. Swor, Lauren A. Hudak, Jose L. Pascual, Mark J. Seamon, Erica Harris, Claire Pearson, David A. Peak, Roland C. Merchant, Robert M. Domeier, Niels K. Rathlev, Brian J. O’Neil, Paulina Sergot, Leon D. Sanchez, Steven E. Bruce

Psychology Faculty Works

Patients exposed to trauma often experience high rates of adverse post-traumatic neuropsychiatric sequelae (APNS). The biological mechanisms promoting APNS are currently unknown, but the microbiota-gut-brain axis offers an avenue to understanding mechanisms as well as possibilities for intervention. Microbiome composition after trauma exposure has been poorly examined regarding neuropsychiatric outcomes. We aimed to determine whether the gut microbiomes of trauma-exposed emergency department patients who develop APNS have dysfunctional gut microbiome profiles and discover potential associated mechanisms. We performed metagenomic analysis on stool samples (n = 51) from a subset of adults enrolled in the Advancing Understanding of RecOvery afteR traumA …

Use Of Serial Smartphone-Based Assessments To Characterize Diverse Neuropsychiatric Symptom Trajectories In A Large Trauma Survivor Cohort, Francesca L. Beaudoin, Xinming An, Archana Basu, Yinyao Ji, Mochuan Liu, Ronald C. Kessler, Robert F. Doughtery, Donglin Zeng, Kenneth A. Bollen, Stacey L. House, Jennifer S. Stevens, Thomas C. Neylan, Gari D. Clifford, Tanja Jovanovic, Sarah D. Linnstaedt, Laura T. Germine, Scott L. Rauch, John P. Haran, Alan B. Storrow, Christopher Lewandowski, Paul I. Musey, Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Brittany E. Punches, Michael C. Kurz, Robert A. Swor, Vishnu P. Murty, Meghan E. Mcgrath, Lauren A. Hudak, Jose L. Pascual, Elizabeth M. Datner

Psychology Faculty Works

The authors sought to characterize adverse posttraumatic neuropsychiatric sequelae (APNS) symptom trajectories across ten symptom domains (pain, depression, sleep, nightmares, avoidance, re-experiencing, anxiety, hyperarousal, somatic, and mental/fatigue symptoms) in a large, diverse, understudied sample of motor vehicle collision (MVC) survivors. More than two thousand MVC survivors were enrolled in the emergency department (ED) and completed a rotating battery of brief smartphone-based surveys over a 2-month period. Measurement models developed from survey item responses were used in latent growth curve/mixture modeling to characterize homogeneous symptom trajectories. Associations between individual trajectories and pre-trauma and peritraumatic characteristics and traditional outcomes were compared, along …

Evaluation Of Current Monitoring Practices For Patients Receiving Infliximab, Yujin Hong Pharmd, Michael Schaedler Pharmd, Bcps, Bcop, Vincent Do Pharmd, Bcps, Bctxp

Posters

• Infliximab is used for a wide range of inflammatory conditions including Crohn’s disease, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, and plaque psoriasis.
• Patients should be closely monitored for development of signs and symptoms of active tuberculosis and latent infection, hepatitis B virus, and human immunodeficiency virus (HIV) during treatment with infliximab following termination of therapy.
• Hematologic abnormalities have also been reported in patients receiving infliximab and caution should be exercised in patients being treated with infliximab who have ongoing or a history of significant hematologic abnormalities.
• Patients with symptoms of signs of liver dysfunction should be evaluated for …

Kejahatan Transnasional Di Indonesia: Studi Kasus Yakuza Sebagai Organisasi Kejahatan Internasional, Adi Saputra Rusli, Yanwar Iswahyudi Mansur, Nisrina Arumdanie, Biky Uthbek Mubarok

Jurnal Kajian Stratejik Ketahanan Nasional

This article presents an analysis of the Yakuza phenomenon, an organized crime organization with deep historical roots in Japan. Through a qualitative approach, this research explores the history and development of the Yakuza, their criminal focus, operational networks, and their impact both national and international levels. The Japanese government's efforts to combat the Yakuza, on a national and global scale, are detailed, including programs for drug prevention, anti-human trafficking, and counter-terrorism. In an international context, the Yakuza is known for its extensive networks, creating new challenges in global security. This research also highlights the importance of global efforts to counter …

Liquid Chromatography Mass Spectrometry Method Development For The Determination Of Β–Defensins In Bovine Milk, Elisha Ogbebor

Masters Theses & Specialist Projects

Bovine mastitis is caused by a wide range of pathogens which results in a substantial economic loss for the dairy cattle livestock industry. β-defensins are a part of the innate immune system and act as the first line of defense against mastitis in bovine. β-defensins (~6- 10kDa) are antimicrobial peptides that contain about 28 to 67 amino acids, the presence of six cysteine residues results in their three disulfide bonds and a β-sheet structure. A few β- defensins have been identified in cows based on the site of occurrence and time of expression in tissue, but not in milk. A …

Towards The Quantification Of Estrone And 17Β-Estradiol Conjugates In Dairy Cattle Urine Sorptive Stir Bar Extraction And Gas Chromatography-Mass Spectometry, S.M. Istiak Ahmed

Masters Theses & Specialist Projects

The global concern regarding the presence of compounds with estrogenic properties in the environment has grown significantly. Endocrine-disrupting compounds (EDCs) are environmental pollutants that disrupt the endocrine systems of both wildlife and humans. Estrogens, with their potent estrogenic effects, are particularly noteworthy among the various substances with endocrine-disrupting properties. They are of concern due to their prevalence in the environment, especially due to dairy waste contamination. These lipophilic compounds can accumulate in livestock fat tissues, potentially entering the human food chain. Sulfated forms of estrone and β- estriol, which exhibit a higher degree of saturation than their non-conjugated counterparts, have …