Digital Commons Network^™

Cobalt Chromium In Biomedical Applications And The Development Of A Pspp Map, Nouralhouda Jamal

BCoE Publications

During the world wars, Cobalt-Chromium (Co-Cr) alloys gained prominence for their use in aircraft engine components, where they exhibited high temperature strength and durability. They are used in a wide range of industries due to their unique set of qualities, particularly strength, corrosion resistance, and biocompatibility. They have emerged as versatile materials with a broad spectrum of applications, from aerospace and automotive components to biomedical implants.

This paper presents a thorough analysis of its composition, processing techniques, microstructure, mechanical properties, and performance characteristics. The primary goal of this project is to develop a PSPP (Process, structure, properties, and performance) map …

Secondary Electrons And Compton X-Ray Generation In Solid And Heated Biological Sample In The Presence Of Radiologic Contrast Media, Vanessa Robinson, Daler Djuraev, Fatima Ahmed

Publications and Research

Our goal is identification of secondary electrons and Compton photons when externally infused radiological contrast from iodine and gadolinium interferes with calcium and iron in tissues. This could help develop next generation of x-ray methods as well as mechanistic understanding of toxic effects of radiology contrast materials on living tissue and agriculture. Changes in tissue minerals over time, aging and heat stress are manipulated in our experiments by infusing imaging contrast agents that consist of large atoms like Gadolinium and Iodine. These have chelation properties to alter electron distribution of proteins and carbohydrates of biological matrix. Our experiments try to …

Pick Your Poison: How Aspartame Causes Anxiety, Abby J. Kersey, Baylee R. Kram, Blessing O. Okosun, Diane C. Darland

Arts & Sciences Undergraduate Showcase

BLUF: Limit your aspartame consumption!

Studies have shown that consecutive aspartame consumption at as little as 7% of the FDA recommended daily intake can cause anxiety symptoms in ~8 days. Not only that, but after 12 weeks of consumption, it was proven that the anxiety symptoms are passed to the offspring two generations later. That means if you have roughly one to two 32 oz Diet Cokes per day, your children and grandchildren will show symptoms of anxiety even if they never consume aspartame themselves. It is important to note that aspartame is in many foods and products labeled as …

Chronic Jet Lag Alters Gut Microbiome And Mycobiome And Promotes The Progression Of Mafld In Hfhfd-Fed Mice, Ruoyi Zheng, Xingwei Xiang, Ying Shi, Anqi Qiu, Xin Luo, Junyan Xie, Ryan D. Russell, Dongmei Zhang

Health & Human Performance Faculty Publications

Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common chronic liver disease worldwide. Circadian disruptors, such as chronic jet lag (CJ), may be new risk factors for MAFLD development. However, the roles of CJ on MAFLD are insufficiently understood, with mechanisms remaining elusive. Studies suggest a link between gut microbiome dysbiosis and MAFLD, but most of the studies are mainly focused on gut bacteria, ignoring other components of gut microbes, such as gut fungi (mycobiome), and few studies have addressed the rhythm of the gut fungi. This study explored the effects of CJ on MAFLD and its related microbiotic …

International Phd Student's Educational Journey Culminates At Uab, Micah Hardge

Browse All News

No abstract provided.

Liquid Biopsy: From Concept To Clinical Application, Catherine Alix-Panabières, Dario Marchetti, Julie E. Lang

Pathology Research and Scholarship

The diagnosis and treatment of cancer presents a physical and mental burden to the patient, often involving diagnostic biopsies and surgeries or chemotherapeutic approaches with severe side-effects. Advances which enable early detection of cancer and close monitoring of the disease course without invasive procedures, and which can underpin a tailored approach to treatment, can therefore make a big difference to the quality of life of patients. Liquid biopsies can be used to access tumor cells and tumor DNA circulating in the blood. Monitoring these species can provide a minimally invasive and repeatable means to detect cancer, or gain information about …

Leucine Lock: An Amplified Rapid Antigen Detection System, Matthew David Goff

Theses and Dissertations

Rapid diagnostic tests for COVID-19, influenza, and blood analytes currently have many drawbacks. They vary greatly in accuracy, are expensive to manufacture, and can be insufficiently sensitive to small antigen loads. Leucine lock is designed to rectify these issues that exist in current rapid diagnostics by creating a rapid antigen test with minimal background activity, tunable sensitivity, and low manufacturing cost. Leucine lock consists of a novel leucine zipper containing an intramolecular hairpin, an ScFv antigen binding domain, and a fluorophore reporter in a FRET combination. By altering the number of hydrophobic and electrostatic mismatches in the intramolecular hairpin, as …

Drop Retention And Departure In Shear Flow On Structured Superhydrophobic Surfaces, Blake Morgan Lyons

Theses and Dissertations

Water is often found adhering to surfaces in droplet form. Droplets can develop as a result of precipitation, condensation, or chemical reactions. Drops are retained or held on a surface due to a retention force exerted on the drop by the surface. This retention force is a function of the surface tension of the liquid, drop geometry, and the contact angle between the drop and the surface. When external or body forces exceed this retention force the drop begins to move. This thesis seeks to understand and quantify the forces present at the point of droplet departure once it begins …

The Effect Of Percussive Massage On The Maintenance Of Skeletal Muscle Health During Limb Unloading, Mohadeseh Ahmadi

Theses and Dissertations

A period of skeletal muscle disuse leads to muscle mass and strength loss and compromised metabolic health. Several studies suggest that passive mechanical stimulation may protect against the detrimental effects of disuse in skeletal muscle. This study assessed the effect of the twice-daily application of percussive massage in mitigating the adverse effects of muscle disuse during ten days of leg unloading. Seventeen participants (7 women and 10 men; 18-35 yrs.) were randomly assigned to either control or massage groups, both undergoing leg unloading. The data revealed that both groups similarly experienced significant reductions in muscle strength (-14%±5.9; p<.0001), quadriceps volume (-4.2%±2.8; p<.0001), myofiber cross-sectional area (-8.2%±1.8; p<.0001), and maximal mitochondrial respiration (-20%±9.1; p<.0001). Fatty acid-supported respiration decreased in the control group (-30.4±18.5%; p= 0.0008) and remained unchanged in the massage group. Hydrogen peroxide (H2O2) flux normalized to oxygen consumption exhibited a significant interaction between group and time, particularly in the absence of ADP, where H2O2 flux increased only in the control group (control: 29.9±26.5%, massage: -13±22.6%; p=0.01). There was no change in the H2O2 flux after the addition of ADP. In conclusion, ten days of limb unloading resulted in diminished muscle size, strength, and mitochondrial respiration. Percussive massage was insufficient to prevent the loss of muscle mass, force production, or carbohydrate-supported respiration. However, it exhibited potential protective effects against the decline in mitochondrial fatty acid-supported respiration.

Faculty Senate Executive Committee Agenda December 11, 2023, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• 3:30 Call to Order
• 3:35 University Business
• 3:50 Faculty Senate Business
• Board of Education Meeting - John Ferguson
• 4:00 Information
• Education Policies Committee
• 4:00 Reports
• 4:25 Old Business
• 4:30 New Business
• Adjourn: 4:30 pm

Structural Features Of Hiv-1 Integrase In The Late Stage Of Viral Replication, Tolga Catmakas

Dissertations

HIV-1 integrase (IN) is an essential enzyme for the viral life cycle as it integrates viral genomic material into the host cell genome. In addition to its’ essential catalytic function, IN has another important non-catalytic role where it binds the viral RNA to facilitate successful particle maturation during the viral life cycle. A significant number of IN mutants, addressed as class II IN mutants, show various defects, affecting different steps of the viral life cycle. Class II IN mutants exhibit aberrant morphology where viral ribonucleoprotein particles are mislocalized outside of the capsid core. This phenomenon can be observed in the …

Educational Policies Committee Agenda December 7, 2023, Utah State University

Educational Policies Committee

• Subcommittee Reports
• Curriculum Subcommittee (Chad Simon)
• Academic Standards Subcommittee (Renee Galliher)
• General Education Subcommittee (Matt Sanders)

Anatomy Of The Ankle And Ankle Injuries In Athletes, Isabelle G. West

Honors Capstones

The purpose of this project was to learn about the anatomy of the ankle joint, explore common ankle injuries in athletes, and research how they are treated overall and in a physical therapy setting. To do so, a dissection of the ankle joint was completed with Mrs. Kara Coffman-Rea in the cadaver lab as well as an exploration of plastinated models. Additionally, a literature review of current research on the ankle was completed. Though many structures of the ankle joint were identified through dissection, the focus of the literature review is on the structures of the lateral ankle and the …

Violence Against Healthcare Workers, Nichole Osgood

Honors Theses

Workplace violence is any act or threat of physical violence, harassment, intimidation, or other threatening disruptive behavior that occurs at work (US Department of Labor, 2023). There are a handful of different types of workplace violence that include but are not limited to physical violence, verbal abuse and threats, sexual harassment, and psychological trauma (US Department of Labor, 2023). Workplace violence, a multifaceted phenomenon, is not a new concern, but its pervasiveness and intensity in healthcare settings have reached alarming proportions in recent years. In a meta-analysis, it was noted that workplace violence against healthcare workers of any kind was …

Covid-19 Breakthrough Infections In Type 1 Diabetes Mellitus: A Cross-Sectional Study By The Covid-19 Vaccination In Autoimmune Diseases (Covad) Group, Suhrud Panchawagh, Naveen Ravichandran, Bhupen Barman, Arvind Nune, Mahnoor Javaid, Abraham Edgar Gracia-Ramos, Jessica Day, Mrudula Joshi, Masataka Kuwana, Sreoshy Saha

Medical College Documents

To investigate the frequency, profile, and severity of COVID-19 breakthrough infections (BI) in patients with type I diabetes mellitus (T1DM) compared to healthy controls (HC) after vaccination. The second COVID-19 Vaccination in Autoimmune Diseases (COVAD-2) survey is a multinational cross-sectional electronic survey which has collected data on patients suffering from various autoimmune diseases including T1DM. We performed a subgroup analysis on this cohort to investigate COVID-19 BI characteristics in patients with T1DM. Logistic regression with propensity score matching analysis was performed. A total of 9595 individuals were included in the analysis, with 100 patients having T1DM. Among the fully vaccinated …

Genomic And Proteomic Analysis Of Five Vi01-Like Phages Reveals Wide Host Range And Multiple Tail Spike Proteins, Evan Harris

Theses and Dissertations

The number of illnesses attributable to antibiotic resistant bacterial infections are on the rise. According to the CDC, by 2050, complications due to antibiotic resistant infections are set to become the most prevalent cause of death worldwide, overtaking both cancer and heart disease in number. We are required to look for supplements to aid antibiotics in the fight against bacteria because it's becoming increasingly clear that antibiotics alone will fail in the face of multidrug-resistant strains. Bacteriophages are natural killers of bacteria and can thus be weaponized to treat multidrug-resistant infections. When a phage is discovered, our databases need to …

Youth Identity And Postsecondary Decision Making In A Rural State: Evidence Of A College For All Master Narrative, Jayson Seaman, Cindy L. Hartman, Andrew D. Coppens, Erin H. Sharp, Sarah Jusseaume, Molly Donovan

Faculty Publications

This study examined the normative messages that inform youth postsecondary decision making in a predominantly rural state in the northeastern U.S., focusing on the institutionalization and circulation of identity master narratives. Using a multilevel, ecological approach to sampling, the study interviewed 33 key informants in positions of influence in educational, workforce, and quality of life domains. Narrative analysis yielded evidence of a predominant master narrative – College for All – that participants described as a prescriptive expectation that youth and families orient their postsecondary planning toward four-year, residential baccalaureate degree programs. Both general and domain-specific aspects of this master narrative …

Jwst: Deuterated Pahs, Pah-Nitriles, And Pah 4 Overtone And Combination Bands I: Program Description And First Look, C. Boersma, L. J. Allamandola, Vincent J. Esposito, A. Maragkoudakis, J. D. Bregman, P. Temi, T. J. Lee, R. C. Fortenberry, E. Peeters

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

A first look is taken at the NIRSpec 1–5 μm observations from James Webb Space Telescope program 1591 that targets seven objects along the low-mass stellar life cycle with polycyclic aromatic hydrocarbon (PAH) emission. Spectra extracted from a 1'.'5 radius circular aperture are explored, showing a wealth of features, including the 3 μm PAH complex, the PAH continuum, and atomic and molecular emission lines from H i, He, H₂, and other species. CO₂- and H₂O-ice absorption and CO emission is also seen. Focusing on the bright-PDR position in M17, the PAH CH stretch falls …

Spawning Asynchrony Of The Endangered Acropora Cervicornis: Are Light Pollution And Abnormally Warm Temperatures The Culprits?, Krista Laforest

All HCAS Student Capstones, Theses, and Dissertations

The persistence of reefs relies on mature corals spawning synchronously to maximize fertilization and produce larvae to replenish local populations. Corals synchronize the release of gametes by responding to temperature, sun, and moon light cycles; however, abnormalities in these patterns can disrupt synchrony. This study is the first to describe regional asynchronous spawning of Acropora cervicornis by quantifying gamete development and spawning times among two reefs, an in situ nursery off Fort Lauderdale, and an in situ nursery in the Florida Keys. While A. cervicornis in the Florida Keys synchronously spawned within the predicted window of 2-5 days after the …

Investigating The Effects Of A Southward Flow In The Southeastern Florida Shelf Using Robotic Instruments, Alfredo Quezada

All HCAS Student Capstones, Theses, and Dissertations

We deployed a Slocum G3 glider fitted with an acoustic Doppler current profiler (ADCP), a Conductivity-Temperature-Depth sensor (CTD), optics sensor channels, and a propeller on the Southeastern Florida shelf. The ADCP and CTD provide continuous measurements of Northern and Eastern current velocity components, salinity, temperature, and density, throughout the water column in a high-current environment. The optics sensor channels are able to provide measurements of chlorophyll concentrations, colored dissolved organic matter (CDOM), and backscatter particle counts. Additionally, for one of the glider deployments, we deployed a Wirewalker wave-powered profiling platform system also fitted with an ADCP and a CTD in …

Stress Management Experiences Of Msw Graduates Transitioning From College To Child Welfare, Danielle Linette Young

Walden Dissertations and Doctoral Studies

No abstract provided.

December 7, 2023, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Common Snook (Centropomus Undecimalis) Neurocranium, Ryan Robison, Lesley Wallace, David Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

Neurocranium length of 16.5 cm Common Snook (Centropomus undecimalis), collected from Dr. Kerstetter's Lab on 10/23 by Ryan Robison and Lesley Wallace.

Yellow Grouper (Epinephelus Awoara), Tyler Jurain, David Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

Continuity Of Care In The Post-Partum Period, Ashley Quezada

MSN Capstone Projects

Maternal mortality rates in the United States have been a growing concern over the past decade, with rates continuing to climb as recent studies have been published. The total maternal mortality rate in the United States in 2018 was 17.4 and has increased to 32.9 as of 2021, while other developed countries continue to decline (Hoyert, 2023). The maternal mortality rate is the number of deaths per 100,000 live births. More than 50% of pregnancy-related deaths in the United States occur after delivery, in the post-partum period (Melillo, 2020). The purpose of this report is to not only bring light …

The Grizzly, December 7, 2023, Marie Sykes, Erin Corcoran, Georgia Gardner, Hannah Conley, Kate Horan, Sean Mcginley, Amelia Kunko, Dominic Minicozzi

Ursinus College Grizzly Newspaper, 1978 to Present

Spring 2023 Recap • Fall 2023 Recap • Farewell From the News Editor • Farewell From the Web Editor • Students Surprise With Spotify Wrapped Lists • 2023 Crossword • Reflections From Ursinus' December Graduates • Ursinus Athletics Fall 2023 Recap: Men's • Ursinus Athletics Fall 2023 Recap: Women's

Biophysical Factors Affecting Habitat Suitability For Crassostrea Virginica, Jason D. Tilley

Dissertations

Oyster reefs provide a variety of important ecosystem services. However, the mortality rate of eastern oyster, Crassostrea virginica, the dominant species that produces oyster reefs in the northern Gulf of Mexico, is increasing at an alarming rate due to a variety of abiotic and biological factors. I examined how biophysical factors, including the less-studied fatty acid profiles of the suspended particulate matter on which oysters feed, influenced morphometric condition of C. virginica.

I sampled suspended particulate matter (SPM) and oysters in-situ in the western Mississippi Sound, which historically supported the majority of oyster production in Mississippi waters. Sampling …

Characterizing Stress Granule Regulation By Pas Kinase, Ataxin-2 And Ptc6 And Investigating The Lifespan Of Covid-19 Virus On Currency, Colleen R. Newey

Theses and Dissertations

The protein Ataxin-2 is a known positive regulator of stress granules in humans, mice and yeast (known as yeast PBP1). Due to the role that stress granules play in diseases including Amyotrophic Lateral Sclerosis (ALS) and cancer, this thesis investigates the role of Ataxin-2 and its protein binding partners in stress granule development and its effects on various metabolic phenotypes of the cell. PAS kinase is a sensory protein kinase, conserved from yeast to man, which regulates respiration and lipid biosynthesis. Our lab discovered that PAS kinase phosphorylates and activates Ataxin-2 in yeast, and that PAS kinase overexpression enhances localization …

Soil Health In American Sports Fields, Miria C. Barnes

Theses and Dissertations

Healthy soils are essential for sustaining the world's ecosystems and maintaining human lifestyles. The adoption of biological, chemical, and physical analyses to assess soil health is a relatively new concept with a paucity of scientific work assessing how these metrics are affected by field management in urban systems Soil samples (n = 110) were collected from a diverse range of sports fields and, for comparative purposes, golf courses, farm fields, non-sport urban, undisturbed forest, and non-vegetated sandy soils. The samples were then analyzed using biological, chemical, and physical metrics to determine if there were significant differences between sport/golf venues and …

Interfacial Properties Of Hybrid Lipid-Polymer Bilayers: Applications In Drug Delivery And Biosensors, Keith L. Willes

Theses and Dissertations

Amphiphilic block copolymers are unique macro-molecules capable of self-assembling into bilayers analogous to naturally occurring lipid membranes. When combined with lipids, these copolymers form hybrid membranes with unique and sometimes unpredictable properties, including increased chemical and mechanical stability. These synthetically enhanced biological structures represent a versatile platform suitable for a wide range of applications, from advanced biosensing devices to drug delivery systems. The realization of these advancements necessitates a deep understanding of material properties, including the ability to predict and control interfacial behaviors. It has been shown that in the case of pure lipid membranes, interfacial behaviors are dominated by …