Digital Commons Network^™

Condition Assessment Of The Northern Climatic Research House At The Usda Forest Service Forest Products Laboratory, Tanaya Johnson

Theses and Dissertations

In 2001 a Northern Climatic Test House (the House) was constructed to demonstrate appropriate and novel building techniques and materials for the upper Midwest region of the USA. The House is a 2,300-square-foot, two-story structure located on the grounds of the USDA Forest Service Forest Products Laboratory (FPL) in Madison, Wisconsin. It is considered a research structure and not part of the FPL’s building inventory. Following construction, the House was heated and cooled but not occupied. Regular (sometimes daily) tours were conducted from it’s opening until about 2008, when tours had diminished to less than one per week. Since eliminating …

Study Of Surface And Groundwater Quality And Quantity At Watershed Scale In Mississippi, Dipesh Nepal

Theses and Dissertations

Hydrology and water quality are affected by land use and climate changes. Mississippi’s diverse agro–ecosystem comprises of a range of land use land cover (LULC) including agriculture, forest, wetlands, urban, and grasslands. The objectives of this study were to investigate the impacts of various factors such as Best Management Practices (BMPs), wetlands, LULC, and climate changes on water quality and quantity. The hydrologic and water quality responses to dynamic LULC input in Soil and Water Assessment Tool (SWAT) were evaluated. Results showed that agricultural and forest expansion were major drivers of hydrologic and water quality changes in Big Sunflower River …

Cement Stabilization Of Poorly Graded Sand, Lana Grayson Brown Sisung

Theses and Dissertations

Stabilization of poorly graded sand in full-scale applications is challenging. This thesis evaluated cement-stabilized sand and had two objectives: (1) evaluation of stabilized material using the PM device to quantify engineering properties for future comparison to alterative materials and to investigate the effectiveness of the device with sand and (2) investigation of the merits of alternative application of cement to sand to benchmark against other topically applied materials. The PM device was successfully used to recommend 10% cement for field studies with one sand, successfully allowed data collection in laboratory and field applications, and its potential in sand seems promising …

Opportunities For Mental Health Interventions In Rural Mississippi Communities During The Covid-19 Pandemic: A Quantitative Analysis, Brice Fortinberry

Theses and Dissertations

COVID-19 presented unique challenges for rural Mississippi communities including impacts on the mental health of rural individuals. This research study aimed to identify opportunities for mental health interventions to provide health promotion professionals with quantitative data on the accessibility and the likelihood of engagement with mental health-fostering behaviors. A secondary objective of this research was to categorize these behaviors within the constructs of the Social Ecological Model. Demographics for rural Mississippi communities were collected and displayed, and using multivariate analyses including Spearman’s correlation and a Mann-Whitney U test the correlation between mental health fostering behaviors and demographic factors was obtained. …

Increased Coding Potential Of Bovine Herpesvirus 1, Victoria Jefferson

Theses and Dissertations

Bovine respiratory disease (BRD) costs the cattle industry millions of dollars in costs in treatment and loss every year in the United States. A significant pathogen often contributes to BRD is Bovine Herpesvirus 1 (BoHV-1), a double stranded DNA virus with the ability to establish latency in the trigeminal ganglia and neurons. Primary infection with BoHV-1 results in immunosuppression that increases the risk of secondary bacterial infection and pneumonia. Because herpesviruses infect their hosts for life and can be reactivated in times of stress, BoHV-1 can present a recurring risk of BRD. The following research aims to expand the knowledge …

Improved Herbicide Selectivity In Tomato By Safening Action Of Benoxacor, 2,4,6-T, Melatonin, And Fenclorim, Tabata Raissa De Oliveira

Theses and Dissertations

Safeners protect crops by enhancing their ability to metabolize various compounds, including herbicides. They primarily work by increasing the crop's tolerance to herbicide damage, activating herbicide-metabolizing proteins, and aiding in their detoxification. This study aimed to investigate the chemical effects of safeners in tomato cultivation and focus on injury reduction and tissue protection. The experiment followed a randomized factorial design (5x4) with four replications repeated twice. We evaluated the effects of herbicides (dicamba, 2,4-D, metribuzin, and sulfentrazone at 1/100) and safeners (benoxacor, fenclorim, melatonin, 2,4,6-T, and an untreated control). Safeners were applied to the seeds before sowing, and herbicides were …

Dynamic Segmental Kinematics Of The Lumbar Spine During Diagnostic Movements, Paul Mcmullin

Theses and Dissertations

While lumbar kinematics can be measured in vivo, most measurements are invasive (such as percutaneous bone pins), provide high doses of radiation (such as biplane fluoroscopy), or are taken with the patient in a static position (such as MRIs). Recent work suggests that lumbar kinematics can be determined by dynamic measurements of epidermal strain in the lower back. This work aims to develop and examine a method of examining lumbar kinematics via optoelectronic motion capture utilizing skin-mounted markers in the lumbar region. Two studies were performed. One study examined lumbar epidermal strain in 28 asymptomatic subjects during diagnostic movements, while …

Acs, George, Sophia Maier Garcia

Bronx Jewish History Project

George Acs was born in Hungary and was brought, as a three year old, to the United States in 1957, after his parents fled the Hungarian Revolution in 1956. His mother’s cousin, who survived Auschwitz with her, had an apartment in the Bronx and they moved in with her upon arriving in the United States. Eventually they would live on 174th Street and Southern Boulevard, which was a Jewish area but in the process of transitioning by the time they moved there in 1957 until they left in 1964 and moved to Lydig Avenue off Pelham Parkway, which was Jewish …

Identification Of Ct-Based Non-Invasive Radiomic Biomarkers For Overall Survival Prediction In Oral Cavity Squamous Cell Carcinoma, Xiao Ling, Gregory S. Alexander, Jason Molitoris, Jinhyuk Choi, Lisa Schumaker, Ranee Mehra, Daria A. Gaykalova, Lei Ren

Department of Radiation Oncology Faculty Papers

This study addresses the limited non-invasive tools for Oral Cavity Squamous Cell Carcinoma (OSCC) survival prediction by identifying Computed Tomography (CT)-based biomarkers to improve prognosis prediction. A retrospective analysis was conducted on data from 149 OSCC patients, including CT radiomics and clinical information. An ensemble approach involving correlation analysis, score screening, and the Sparse-L1 algorithm was used to select functional features, which were then used to build Cox Proportional Hazards models (CPH). Our CPH achieved a 0.70 concordance index in testing. The model identified two CT-based radiomics features, Gradient-Neighboring-Gray-Tone-Difference-Matrix-Strength (GNS) and normalized-Wavelet-LLL-Gray-Level-Dependence-Matrix-Large-Dependence-High-Gray-Level-Emphasis (HLE), as well as stage and alcohol usage, …

A Phenotypically Robust Model Of Spinal And Bulbar Muscular Atrophy In Drosophila, Kristin Richardson, Medha Sengupta, Alyson Sujkowski, Kozeta Libohova, Autumn C. Harris, Robert Wessells, Diane E. Merry, Sokol V. Todi

Department of Biochemistry and Molecular Biology Faculty Papers

Spinal and bulbar muscular atrophy (SBMA) is an X-linked disorder that affects males who inherit the androgen receptor (AR) gene with an abnormal CAG triplet repeat expansion. The resulting protein contains an elongated polyglutamine (polyQ) tract and causes motor neuron degeneration in an androgen-dependent manner. The precise molecular sequelae of SBMA are unclear. To assist with its investigation and the identification of therapeutic options, we report here a new model of SBMA in Drosophila melanogaster. We generated transgenic flies that express the full-length, human AR with a wild-type or pathogenic polyQ repeat. Each transgene is inserted into the same safe …

Novel Sox10 Indel Mutations Drive Schwannomas Through Impaired Transactivation Of Myelination Gene Programs, Erik A Williams, Ajay Ravindranathan, Rohit Gupta, Nicholas O Stevers, Abigail K Suwala, Chibo Hong, Somang Kim, Jimmy Bo Yuan, Jasper Wu, Jairo Barreto, Calixto-Hope G Lucas, Emily Chan, Melike Pekmezci, Philip E Leboit, Thaddeus Mully, Arie Perry, Andrew Bollen, Jessica Van Ziffle, W Patrick Devine, Alyssa T Reddy, Nalin Gupta, Kristen M Basnet, Robert J B Macaulay, Patrick Malafronte, Han Lee, William H Yong, Kevin Jon Williams, Tareq A Juratli, Douglas A Mata, Richard S P Huang, Matthew C Hiemenz, Dean C Pavlick, Garrett M Frampton, Tyler Janovitz, Jeffrey S Ross, Susan M Chang, Mitchel S Berger, Line Jacques, Jun S Song, Joseph F Costello, David A Solomon

Faculty, Staff and Student Publications

BACKGROUND: Schwannomas are common peripheral nerve sheath tumors that can cause severe morbidity given their stereotypic intracranial and paraspinal locations. Similar to many solid tumors, schwannomas and other nerve sheath tumors are primarily thought to arise due to aberrant hyperactivation of the RAS growth factor signaling pathway. Here, we sought to further define the molecular pathogenesis of schwannomas.

METHODS: We performed comprehensive genomic profiling on a cohort of 96 human schwannomas, as well as DNA methylation profiling on a subset. Functional studies including RNA sequencing, chromatin immunoprecipitation-DNA sequencing, electrophoretic mobility shift assay, and luciferase reporter assays were performed in a …

Triassic And Jurassic Possible Planktonic Foraminifera And The Assemblages Recovered From The Ogrodzieniec Glauconitic Marls Formation (Uppermost Callovian And Lowermost Oxfordian, Jurassic) Of The Polish Basin, Malcolm B. Hart, Holger Gebhardt, Eiichi Setoyama, Christopher W. Smart, Jarosław Tyszka

School of Geography, Earth and Environmental Sciences

In the 1960s and 1970s Werner Fuchs of the Austrian Geological Survey (Vienna) described a significant number of new foraminiferal taxa that he considered ancestral to the planktonic foraminifera. All these taxa are well-curated in the collections of the Austrian Geological Survey and have been studied by one of us (Malcolm B. Hart). Some of these taxa, from the Triassic and lowermost Jurassic strata of Austria and northern Italy, are poorly preserved, possibly the result of having an original aragonitic wall structure. None of these taxa possess characters which give the appearance of a planktonic mode of life, although some …

Benzodioxane-Benzamides As Ftsz Inhibitors: Effects Of Linker's Functionalization On Gram-Positive Antimicrobial Activity, Lorenzo Suigo, William Margolin, Eugenia Ulzurrun, Martina Hrast Rambaher, Carlo Zanotto, Victor Sebastián-Pérez, Nuria E Campillo, Valentina Straniero, Ermanno Valoti

Faculty, Staff and Student Publications

FtsZ is an essential bacterial protein abundantly studied as a novel and promising target for antimicrobials. FtsZ is highly conserved among bacteria and mycobacteria, and it is crucial for the correct outcome of the cell division process, as it is responsible for the division of the parent bacterial cell into two daughter cells. In recent years, the benzodioxane-benzamide class has emerged as very promising and capable of targeting both Gram-positive and Gram-negative FtsZs. In this study, we explored the effect of including a substituent on the ethylenic linker between the two main moieties on the antimicrobial activity and pharmacokinetic properties. …

Rad54l2-Mediated Dna Damage Avoidance Pathway Specifically Preserves Genome Integrity In Response To Topoisomerase 2 Poisons, Huimin Zhang, Yun Xiong, Yilun Sun, Jeong-Min Park, Dan Su, Xu Feng, Sarah Keast, Mengfan Tang, Min Huang, Chao Wang, Mrinal Srivastava, Chang Yang, Dandan Zhu, Zhen Chen, Siting Li, Ling Yin, Yves Pommier, Junjie Chen

Faculty, Staff and Student Publications

Type II topoisomerases (TOP2) form transient TOP2 cleavage complexes (TOP2ccs) during their catalytic cycle to relieve topological stress. TOP2ccs are covalently linked TOP2-DNA intermediates that are reversible but can be trapped by TOP2 poisons. Trapped TOP2ccs block transactions on DNA and generate genotoxic stress, which are the mechanisms of action of TOP2 poisons. How cells avoid TOP2cc accumulation remains largely unknown. In this study, we uncovered RAD54 like 2 (RAD54L2) as a key factor that mediates a TOP2-specific DNA damage avoidance pathway. RAD54L2 deficiency conferred unique sensitivity to treatment with TOP2 poisons. RAD54L2 interacted with TOP2A/TOP2B and ZATT/ZNF451 and promoted …

Phenotyping Emt And Met Cellular States In Lung Cancer Patient Liquid Biopsies At A Personalized Level Using Mass Cytometry, Loukia G Karacosta, Danny Pancirer, Jordan S Preiss, Jalen A Benson, Winston Trope, Joseph B Shrager, Arthur Wai Sung, Joel W Neal, Sean C Bendall, Heather Wakelee, Sylvia K Plevritis

Faculty, Staff and Student Publications

Malignant pleural effusions (MPEs) can be utilized as liquid biopsy for phenotyping malignant cells and for precision immunotherapy, yet MPEs are inadequately studied at the single-cell proteomic level. Here we leverage mass cytometry to interrogate immune and epithelial cellular profiles of primary tumors and pleural effusions (PEs) from early and late-stage non-small cell lung cancer (NSCLC) patients, with the goal of assessing epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) states in patient specimens. By using the EMT-MET reference map PHENOSTAMP, we observe a variety of EMT states in cytokeratin positive (CK+) cells, and report for the first time MET-enriched CK+ …

Ewsr1::Atf1 Orchestrates The Clear Cell Sarcoma Transcriptome In Human Tumors And A Mouse Genetic Model, Benjamin B Ozenberger, Li Li, Emily R Wilson, Alexander J Lazar, Jared J Barrott, Kevin B Jones

Faculty, Staff and Student Publications

Clear cell sarcoma (CCS) is a rare, aggressive malignancy that most frequently arises in the soft tissues of the extremities. It is defined and driven by expression of one member of a family of related translocation-generated fusion oncogenes, the most common of which is EWSR1::ATF1. The EWSR1::ATF1 fusion oncoprotein reprograms transcription. However, the binding distribution of EWSR1::ATF1 across the genome and its target genes remain unclear. Here, we interrogated the genomic distribution of V5-tagged EWSR1::ATF1 in tumors it had induced upon expression in mice that also recapitulated the transcriptome of human CCS. ChIP-sequencing of V5-EWSR1::ATF1 identified previously unreported motifs …

A Thematic Analysis Of Religious Identity And Volunteer Motivation Among Emerging Adult Members Of The Church Of Jesus Christ Of Latter-Day Saints, Jennifer R. Smith

Theses and Dissertations

This study sought insight into the religious and cultural identity of emerging adults belonging to the Church of Jesus Christ of latter-day Saints(LDS) and the impact such identity had in relation to volunteering motivation. Participants included 24 emerging adult college students belonging to the Church. Thematic analysis was used to determine influencing factors that led to Church membership and how Church membership shaped self-perception. Participants shared volunteer experiences and motivation to volunteer in relation to Deci and Ryan’s (2000) self-determination theory (SDT) was examined. The motivation of relatedness was identified among 100% of participants as compared to competence (37.5%) and …

Sign-Symmetry And Frustration Index In Signed Graphs, Abdulaziz Alotaibi

Theses and Dissertations

A graph in which every edge is labeled positive or negative is called a signed graph. We determine the number of ways to sign the edges of the McGee graph with exactly two negative edges up to switching isomorphism. We characterize signed graphs that are both sign-symmetric and have a frustration index of 1. We prove some results about which signed graphs on complete multipartite graphs have frustration indices 2 and 3. In the final part, we derive the relationship between the frustration index and the number of parts in a sign-symmetric signed graph on complete multipartite graphs.

The Impact Of Prior Pandemic Planning On Health Outcomes During The Covid-19 Pandemic: A Study Of Local Government Pandemic Planning In The United States, Karissa D. Bergene

Theses and Dissertations

In late 2019, scientists discovered a novel strain of coronavirus originating out of Wuhan, China. By January 2020, the United States (U.S.) saw its first positive case of coronavirus and the public was still unsure how serious of an epidemic this would be. By the time the World Health Organization declared the novel coronavirus disease (COVID-19) epidemic a “global pandemic” on March 11, 2020, world leaders, public health experts, scientists, and public administrators kicked into high gear to start serious pandemic response efforts. The public sector is typically the responsible authority for the preparedness, response, mitigation, and recovery of such …

Stream Water Quality Under Baseflow Conditions In A Livestock Production Area, Maryi Lorena Chavarro Chaux

Theses and Dissertations

This study evaluates the spatial and temporal impacts of implemented Best Management Practices (BMP) on stream water quality under baseflow conditions in a stream segment affected by livestock production. The BMPs includes 10-m fenced riparian zone and crossing paths along the reach segment. Grab water samples and water quality monitoring were collected biweekly from July 2019 to March 2022. Water quality parameters included temperature, dissolved oxygen, electric conductance, total dissolved solids, turbidity, and pH. Water samples were lab analyzed for sediments and nutrients. Results evidenced poor water quality before BMPs implementation, with nutrient concentrations exceeding the nation's and state's criteria. …

Advancing Salamander Conservation Efforts In Zoos And Aquaria Through Assisted Reproductive Technologies (Art), Devin Marie Chen

Theses and Dissertations

Salamanders are one of the most at-risk taxa in the world due to habitat destruction, pollution, climate change, invasive diseases, and more. This has led to a need for conservation breeding programs that are often associated with zoos and aquaria. Salamanders can be difficult to breed in captivity, though, due to their dependence on specific environmental cues and other unknown factors that stimulate sperm and egg production. To overcome these challenges, assisted reproductive technologies (ART) such as exogenous hormone administration, sperm cryopreservation, and in-vitro fertilization have been developed to increase offspring propagation and maintain genetic diversity. If genetically robust populations …

A Conceptual Decentralized Identity Solution For State Government, Martin Duclos

Theses and Dissertations

In recent years, state governments, exemplified by Mississippi, have significantly expanded their online service offerings to reduce costs and improve efficiency. However, this shift has led to challenges in managing digital identities effectively, with multiple fragmented solutions in use. This paper proposes a Self-Sovereign Identity (SSI) framework based on distributed ledger technology. SSI grants individuals control over their digital identities, enhancing privacy and security without relying on a centralized authority. The contributions of this research include increased efficiency, improved privacy and security, enhanced user satisfaction, and reduced costs in state government digital identity management. The paper provides background on digital …

Does Mississippi School Principals’ Age, Race, Gender, Educational Attainment, Work Experience In Education, Or Evaluation Scores Influence Accountability Points?, Braxton Dywayne Stowe

Theses and Dissertations

Traditional research agrees that only effective school principals can fully influence student achievement, and school leaders are pivotal to the success of schools in America. Researchers have linked positive student outcomes to further illustrate the point, including student achievement, to high-quality school leadership. The purpose of this study is to assist state and district education leaders in Mississippi in having a more profound knowledge of which principal demographics and characteristics are more directly correlated with the improvement of accountability scores or student achievement. The results of the correlational and regression analysis to determine the relationship between principal variables and the …

The Influence Of At-Planting Insecticide Treatments On Tobacco Thrips, (Thysanoptera:Thripidae), And Reniform Nematode, (Tylenchida:Hoplolaimidae), In Conventional And Thryvon Cotton Systems, Walker Brett Farmer

Theses and Dissertations

One of the objectives of this research was to evaluate the need for an additional imidacloprid seed treatment on ThryvOn^® (Bayer Crop Science^®, St. Louis, MO) cotton to effectively manage tobacco thrips, Frankliniella fusca (Hinds). While evaluating thrips densities and damage ratings, ThryvOn cotton continued to display reduced damage and thrips populations than non-ThryvOn. Thrips populations and damage ratings were consistently reduced when incorporating a higher rate of imidacloprid, but they were not reduced enough to justify the higher rates of imidacloprid. Another objective of this research was to evaluate the impact of aldicarb (AgLogic Chemical^{® …}

Current And Future Perceived Needs And Concerns For Older Adults Aging In Place In Mississippi: Intergenerational Perspectives, Muhammad Riaz

Theses and Dissertations

The study's purpose was to identify the perceived needs and concerns of three generations in a family with an older adult aging in place in Mississippi. This mixed-methods study used snowball sampling in addition to recruitment by community leaders such as Extension agents to collect data through semi-structured interviews and structured questionnaires that asked about current and future problems among aging adults in rural communities in Mississippi. Three generations of Mississippians participated in the study, including older adults (G1; n = 22), adult children (G2; n = 23), and young adult grandchildren (G3; n = 19). Quantitative data were analyzed …

Biochar And Gypsum Effects On Soil Properties And Water Quality In Cotton And Soybean Production Systems In The Mississippi Delta, Amrinder Jakhar

Theses and Dissertations

Intensive tillage practices in the Mississippi Delta degrade soil health, impacting downstream water quality. To address this, two experiments were conducted from 2019 to 2021 and 2020 to 2022 to evaluate the impact of sugarcane biochar and flue gas desulfurization (FGD) gypsum on nutrient leaching losses and soil properties in cotton and soybean cropping systems. Study I applied four biochar rates (0, 10, 20, and 40 Mg ha^-1) to cotton and found improvements in soil properties and subsurface quality, with reduced nutrient leaching losses, except for sulfate and sodium ions. Study II evaluated biochar (10 and 25 Mg …

Taking Care Of What Matters: How Student Involvement And Characteristics Relate To Senior Student Sense Of Belonging, Kayla Pineda

Theses and Dissertations

Student sense of belonging has been a topic of discussion for decades; however, senior student sense of belonging has not been looked at as closely as other groups of students. As seniors transition out of college, institutions must consider that these students become the alumni who contribute through alumni donations and share their experiences with future generations of students.

Looking at data from a single very high research college campus in a rural state, the study explored variables that relate to senior student sense of belonging. Using Ahn and Davis’s (2020a) 4 domains of student sense of belonging, variables were …

Designing An Artificial Immune Inspired Intrusion Detection System, William Hosier Anderson

Theses and Dissertations

The domain of Intrusion Detection Systems (IDS) has witnessed growing interest in recent years due to the escalating threats posed by cyberattacks. As Internet of Things (IoT) becomes increasingly integrated into our every day lives, we widen our attack surface and expose more of our personal lives to risk. In the same way the Human Immune System (HIS) safeguards our physical self, a similar solution is needed to safeguard our digital self. This thesis presents the Artificial Immune inspired Intrusion Detection System (AIS-IDS), an IDS modeled after the HIS. This thesis proposes an architecture for AIS-IDS, instantiates an AIS-IDS model …

Evaluating Selected Properties Of Underutilized Hardwood Species For Fabrication Of Cross-Laminated Timber Industrial Mats, Mercy Itunu Ogunruku

Theses and Dissertations

Softwood is more in demand than hardwood because it is used primarily in the US's largest wood-consuming industry, construction, resulting in increased importation of softwood annually to meet this demand. Hardwood, used for non-structural purposes like furniture and interior designs, is more abundant in US forests. However, some hardwood species are underutilized and undervalued. Cross-laminated timber (CLT) has increased the demand for softwood.

A study evaluated the mechanical and physical properties of three underutilized hardwood species (321 yellow poplar, 393 sweetgum, and 262 red oak specimens) for CLT industrial mat manufacturing. The results showed that red oak had a higher …

Exploring The Impact Of Extracurricular Activities On Adolescent Development: A Study Of Students Attending Schools In Poverty And Non-Poverty Areas, Clifton B. Thames

Theses and Dissertations

Previous literature has indicated a relationship between poverty, participation in extracurricular activities, and developmental outcomes. The current study aimed to investigate and develop a deeper understanding of extracurricular activities (ECAs) and their impacts on adolescent development using two self-report tools, the YES 2.0 and the Delinquent Attitude Scale (DAS). The researcher surveyed 174 high school seniors from students attending schools in poverty areas and students attending schools not located in poverty areas in Mississippi, examining disparities in ECA opportunities, barriers to participation, and the positive and negative impacts of ECAs on development. Additional data were collected from school administrators, allowing …