Digital Commons Network^™

Predictive Looking And Predictive Looking Errors In Everyday Activities, Sophie Su

Arts & Sciences Graduate Student Theses and Dissertations

People spontaneously segment continuous streams of experiences into distinct episodes. Prediction errors are theorized to drive segmentation. However, existing studies exploring the relationship between prediction error and event segmentation lack a continuous measure of prediction error during naturalistic perception and often fail to distinguish between prediction error and prediction uncertainty. Do moment-by-moment fluctuation of prediction errors, not prediction uncertainty during naturalistic event perception correlate positively with segmentation probabilities? To tackle this question, we harnessed the predictive nature of eye movements and introduced a predictive looking model. In this model, individuals’ prior gaze patterns act as predictors for critical features in …

Diet And Nutrition In Inflammatory Bowel Disease: A Review Of The Literature, Scott Manski, Nicholas Noverati, Tatiana Policarpo, Emily Rubin, Raina Shivashankar

Division of Gastroenterology and Hepatology Faculty Papers

Diet is thought to contribute to the development of inflammatory bowel disease (IBD) and may act as a mediator of inflammation in patients with IBD. Patients commonly associate their diet with symptoms and inquire about dietary modifications to manage their IBD. Without clinical guidelines and well-established nutritional data, healthcare providers managing patients with IBD may find it difficult to provide recommendations. Strong evidence for enteral nutrition, particularly in the pediatric population, has been established in Crohn's disease (CD) as a therapeutic option. Enteral nutrition may also serve as an adjunct to an exclusion diet. Recent studies such as the randomized …

Clean Energy & Sustainable Environment By Carbon Dioxide Mitigation Strategies, Md Fahim Shahriar

Mechanical Engineering Theses

Dissolution trapping is one of the most dominant mechanisms for secure storage of CO₂ injected in porous subsurface formations saturated with brine. This study uses a 2D visual Hele-Shaw cell to investigate and visualize the impact of CO₂ injection locations, reservoir dipping angle, permeability heterogeneity, and brine with different initial ionic concentrations on the density-driven convection during CO₂ dissolution (Chapter 2). Also, the role of complex heterogeneity, i.e., irregular permeability distribution in CO₂ dissolution, is investigated using a novel experimental approach to create medium permeability heterogeneity in Hele-Shaw cells (Chapter 3). We observed that the presence …

The Dna Glycosylase Neil2 Is Protective During Sars-Cov-2 Infection, Nisha Tapryal, Anirban Chakraborty, Kaushik Saha, Azharul Islam, Lang Pan, Koa Hosoki, Ibrahim M Sayed, Jason M Duran, Joshua Alcantara, Vanessa Castillo, Courtney Tindle, Altaf H Sarker, Maki Wakamiya, Victor J Cardenas, Gulshan Sharma, Laura E Crotty Alexander, Sanjiv Sur, Debashis Sahoo, Gourisankar Ghosh, Soumita Das, Pradipta Ghosh, Istvan Boldogh, Tapas K Hazra

Faculty, Staff and Students Publications

SARS-CoV-2 infection-induced aggravation of host innate immune response not only causes tissue damage and multiorgan failure in COVID-19 patients but also induces host genome damage and activates DNA damage response pathways. To test whether the compromised DNA repair capacity of individuals modulates the severity of COVID-19 infection, we analyze DNA repair gene expression in publicly available patient datasets and observe a lower level of the DNA glycosylase NEIL2 in the lungs of severely infected COVID-19 patients. This observation of lower NEIL2 levels is further validated in infected patients, hamsters and ACE2 receptor-expressing human A549 (A549-ACE2) cells. Furthermore, delivery of recombinant …

Laboratory Investigations Into Alternative Baits For The Channeled Whelk (Busycotypus Canaliculatus) Fishery, Mary Kate Munley, Elizabeth A. Fairchild, Steven H. Jury, Winsor H. Watson, Shelley A. Edmundson

Faculty Publications

Channeled whelks (Busycotypus canaliculatus) are fished along the eastern US coast using traps typically baited with pieces of female horseshoe crabs (HSC Limulus polyphemus). However, the use of HSC as bait, particularly females, is controversial because they are already heavily fished because their blood contains a substance that the biomedical industry uses to manufacture a test for pathogenic bacteria. Therefore, the goals of this study were to: 1) develop a cost-effective alternative bait that does not rely on HSCs and 2) determine whether whelk are more attracted to female HSC pieces than male HSC pieces. Seventeen different baits were tested …

Sirtuin 6 Activation Rescues The Age-Related Decline In Dna Damage Repair In Primary Human Chondrocytes, Michaela E. Copp, Jacqueline Shine, Hannon L. Brown, Kirti R. Nimmala, Oliver B. Hansen, Susan Chubinskaya, John A. Collins, Richard F. Loeser, Brian O. Diekman

Department of Orthopaedic Surgery Faculty Papers

While advanced age is widely recognized as the greatest risk factor for osteoarthritis (OA), the biological mechanisms behind this connection remain unclear. Previous work has demonstrated that chondrocytes from older cadaveric donors have elevated levels of DNA damage as compared to chondrocytes from younger donors. The purpose of this study was to determine whether a decline in DNA repair efficiency is one explanation for the accumulation of DNA damage with age, and to quantify the improvement in repair with activation of Sirtuin 6 (SIRT6). After acute damage with irradiation, DNA repair was shown to be more efficient in chondrocytes from …

A Drosophila Heart Optical Coherence Microscopy Dataset For Automatic Video Segmentation, Matthew Fishman, Abigail Matt, Fei Wang, Elena Gracheva, Jiantao Zhu, Xiangping Ouyang, Andrey Komarov, Yuxuan Wang, Hongwu Liang, Chao Zhou

2020-Current year OA Pubs

The heart of the fruit fly, Drosophila melanogaster, is a particularly suitable model for cardiac studies. Optical coherence microscopy (OCM) captures in vivo cross-sectional videos of the beating Drosophila heart for cardiac function quantification. To analyze those large-size multi-frame OCM recordings, human labelling has been employed, leading to low efficiency and poor reproducibility. Here, we introduce a robust and accurate automated Drosophila heart segmentation algorithm, called FlyNet 2.0+, which utilizes a long short-term memory (LSTM) convolutional neural network to leverage time series information in the videos, ensuring consistent, high-quality segmentation. We present a dataset of 213 Drosophila heart videos, equivalent …

Biophysical Study Of The Von Willebrand Factor Via Optical Tweezers—Investigating The Collagen Binding Force Profile To Distinguish Types Of Von Willebrand Disease, Leigh Hardin

Honors Theses

von Willebrand disease (vWD) is a genetic disorder due to quantitative or qualitative abnormalities of the von Willebrand factor (vWF). There are three main types of vWD in addition to acquired von Willebrand syndrome. Type 1 is due to a deficiency of vWF, while Type 3 is due to a complete absence of vWF. Type 2 is due to malformed factors and broken into four subtypes: 2A, 2B, 2M, and 2N. Each subtype corresponds to different abnormalities of the protein that affect its binding to other proteins such as collagen, Factor VIII, platelets, etc. Therefore, determining a patient’s type and …

Supreme Court Overreach Through Broad Discretionary Consideration Of Ameliorative Measures In International Child Abduction, Lauren Mayell

Global Business Law Review

This Note provides a critical analysis of the United States Supreme Court's recent decision in Golan v. Saada--a case setting precedent in the area of international child abduction by biological parents. It argues that the Supreme Court oversteps the presiding law in the field through the use of discretionary ameliorative measures. These ameliorative measures do not show evidence of protecting children from grave risk, directly usurp underlying custody proceedings, and hinder expeditious procedures, all of which are required by law in international child abduction cases. Additionally, this Note compares the European Union's approach to ameliorate analysis. Lastly this Note …

The Medical Action Ontology: A Tool For Annotating And Analyzing Treatments And Clinical Management Of Human Disease., Leigh Carmody, Michael Gargano, Sabrina Toro, Nicole A Vasilevsky, Margaret P Adam, Hannah Blau, Lauren E Chan, David Gomez-Andres, Rita Horvath, Megan L Kraus, Markus S Ladewig, David Lewis-Smith, Hanns Lochmüller, Nicolas A Matentzoglu, Monica C Munoz-Torres, Catharina Schuetz, Berthold Seitz, Morgan N Similuk, Teresa N Sparks, Timmy Strauss, Emilia M Swietlik, Rachel Thompson, Xingmin Aaron Zhang, Christopher J Mungall, Melissa A Haendel, Peter N Robinson

Faculty Research 2023

BACKGROUND: Navigating the clinical literature to determine the optimal clinical management for rare diseases presents significant challenges. We introduce the Medical Action Ontology (MAxO), an ontology specifically designed to organize medical procedures, therapies, and interventions.

METHODS: MAxO incorporates logical structures that link MAxO terms to numerous other ontologies within the OBO Foundry. Term development involves a blend of manual and semi-automated processes. Additionally, we have generated annotations detailing diagnostic modalities for specific phenotypic abnormalities defined by the Human Phenotype Ontology (HPO). We introduce a web application, POET, that facilitates MAxO annotations for specific medical actions for diseases using the Mondo …

The Student Movement Volume 108 Issue 11: A Merry Christmas: From The Sm Staff To You, Grace No, Reagan Westerman, Lauren Kim, Nate Miller, Aiko J. Ayala Rios, Corinna Bevier, Lexie Dunham, Madison Vath, Andrew Francis, Katie Davis, Jonathan Clough, Melissa Moore, Bella Hamann, Abby Shim, Robert Zhang, Rodney Bell Ii, Wambui Karanja, Anna Rybachek, Desmond Hartwell Murray, Shandelle Henson, Amelia Stefanescu

The Student Movement v. 108 (2023-2024)

HUMANS

Meet the Professors: New Humans Series, Grace No

Psychology Research, Interviewed by Grace No

What's The Deal With Santa Claus?, Reagan Westerman

Student Worker Interview: Sam Namkung, Interviewed by Lauren Kim

ARTS & ENTERTAINMENT

A Flat World for Our Round One, Nate Miller

Art & Music in Andrews' History - Introduction, Aiko J. Ayala Rios

Why Do I Fell Bad for President Snow?: The Ballad of Songbirds and Snakes Review, Corinna Bevier

Have Yourself a Merry Little Hallmark Christmas, Lexie Dunham

It's Beginning to Sound a Lot Like Christmas: A Christmas Playlist, Madison Vath

NEWS

Questions Answered, Questions Avoided: …

Exploring Lgbt Experiences With Family Planning And Reproductive Health, Isabella Lafratta

Honors Program Theses and Projects

The purpose of this research is to investigate Lesbian, Gay, Bisexual, Transgender (LGBT) healthcare experiences, specifically in relation to family planning and fertility counseling. Sixteen qualitative, individual interviews were completed with participants recruited from LGBT communities on campus, as well as personal contacts and the snowball effect. Data was analyzed using thematic analysis (Braun & Clarke, 2021), and major themes and subthemes were identified. The first overall theme was Uneasiness and Fear which captures the subtheme: Dysphoria Inducement. The second overarching theme, Lack of Focus on Individualized Needs, had the subthemes of Reproductive Care and Transgender Reproductive Care. This describes …

2023-12-08, Board Of Regents, Murray State University

Board of Regents Meeting Minutes

No abstract provided.

2023 Fall Commencement Program: Winona State University, Winona State University

WSU Commencement Programs

This is the Winona State University Spring 2023 commencement program. Commencement was on Friday, December 8, 2023.

Sex And Race Differences In Obesity-Related Genetic Susceptibility And Risk Of Cardiometabolic Disease In Older Us Adults, Hairui Yu, Nicole Armstrong, Greg Pavela

APC Fund

Importance The fat mass and obesity–associated gene (FTO) is associated with obesity phenotypes, but the association is inconsistent across populations. Within-population differences may explain some of the variability observed.

Objective To investigate sex differences in the association between FTO single-nucleotide variants (SNVs) and obesity traits among self-identified non-Hispanic Black and non-Hispanic White US adults, to examine whether the SNVs were associated with cardiometabolic diseases, and to evaluate whether obesity mediated the association between FTO SNVs and cardiometabolic diseases.

Design, Setting, and Participants This cross-sectional study used data from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) …

Cultural Determinants Of Help Seeking - Experiences Of African American Mothers And Professional Mental Health Care, Latoya Ashley

Walden Dissertations and Doctoral Studies

No abstract provided.

Faculty Feed December 8, 2023, College Of Arts & Sciences

News, Magazines and Reports

Student and faculty accomplishments.

Role Of Prmt5 In Ulk1-Mediated Autophagy And Breast Cancer Therapy, Charles Brobbey

MUSC Theses and Dissertations

PRMT5 (Protein arginine methyltransferase 5) is the predominant type II PRMT that monomethylates and symmetrically dimethylates arginine residues of histone and none- histone proteins to regulate diverse cellular processes. PRMT5 overexpression has been implicated in tumorigenesis and other diseases and has gained trac1on as a poten1al an1tumor target with some of its inhibitors being tested in clinical trials. Despite the well- established an1tumor effect of PRMT5 inhibitors, how the efficacy of these inhibitors is regulated is unexplored. We show in this study that autophagy blockage enhances cellular sensi1vity to PRMT5 inhibitor in triple nega1ve breast cancer cells. Both gene1c deple1on …

Green Wood Composites With Natural Preservatives, Thomas Frank Norman

Theses and Dissertations

The purpose of this study is to test the mechanical, dimensional stability, and weathering durability of OSB (oriented strand board) panels that have been treated with varying natural wood preservatives that were chosen from an array of natural antimicrobial compounds. Wood is increasing in popularity for new construction projects but has been limited by its vulnerability to biological degradation. The addition of natural antimicrobial compounds will increase the use life of wood-based strand board allowing its use to expand with the growing construction demand but has little data on how natural antimicrobial compounds impact different properties of the OSB. The …

Catfish Neurocranium 3-D Scan, Pamela Gonzalez, Jarod Johnson, David Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

December 8, 2023 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

An Assessment Of Sentencing Disparities By Race In The State Of Arkansas, Viola Schaeffer

Theses and Dissertations

Past research has found that there are often disparities in sentencing outcomes due to extralegal factors such as race, gender, age, socioeconomic status, education level, and geographic location. The most prominent and widely studied of these factors, however, is race. Specifically, studies have shown that minority offenders (e.g., African Americans) were more likely to receive a lengthier sentence than their White peers. The purpose of this thesis is thus to examine if there is racial bias in sentences levied to violent offenders in Arkansas. This is be done by analyzing sentencing data from the Arkansas Office of the Courts between …

Microbial Ecology Of Alpine Snows: Novel Approaches To Assess Spatial And Temporal Dynamics, Avery Ezra Tucker

Electronic Theses and Dissertations Archive

Snow algae blooms and associated microbial communities play large roles in snow ecosystem processes. Patterns and mechanisms underpinning snow algae bloom spatial distribution and associated microbial community assembly dynamics are poorly understood. To bridge these gaps in knowledge, this dissertation focused on two broad areas: (1) mapping associations of microbial communities and environmental measures between/within snow algae blooms across diverse substrate categories and identifying significant associations between them; (2) metagenome sequencing, offering the first partial genome of Sanguina nivaloides, along with identification of putative functional pathways. Although snow algae are an enigmatic domain in microbial community research, due to the …

Exosome Shedding Is Concordant With Objective Treatment Response Rate And Stratifies Time To Progression In Treatment Naïve, Non-Resectable Hepatocellular Carcinoma, Kelley G. Núñez, Dorota Wyczechowska, Mina Hibino, Tyler Sandow, Juan Gimenez, Ali R. Koksal, Yucel Aydin, Srikanta Dash, Ari J. Cohen, Paul T. Thevenot

School of Medicine Faculty Publications

Translational strategies to characterize and monitor extracellular vesicles such as exosome (EX) shedding and the clinical impact of this data within hepatocellular carcinoma (HCC) remains unclear. In this study, EX shedding was assessed in early-stage HCC and evaluated as a stratification factor for time to progression (TTP) following first-cycle liver-directed therapy (LDT). Plasma EXs were isolated from HCC patients undergoing LDT using ultracentrifugation. Purified EXs were stained using markers CD9 and CD63 and quantified using an ImageStreamX flow cytometer. Circulating EXs expressing CD9 were isolated at 10-fold higher levels compared to CD63. The intensity of CD9+ EX shedding following LDT …

Addressing Water Hyacinth (Pontederia Crassipes) Impacts On Aquatic Biota In Lake Okeechobee, Joseph Salerno

All HCAS Student Capstones, Theses, and Dissertations

The incursion of water hyacinth, Pontederia crassipes in Lake Okeechobee has resulted in management systems to be implemented to reduce the coverage of the invasive macrophyte. Its residence in the Lake Okeechobee ecosystem and the effects it has on organisms in the lake, whether it be positive or harmful is unknown. This study attempted to assess the potential effects that water hyacinth has on aquatic biota in Lake Okeechobee. Biotic data were collected on open water, water hyacinth covered, and native vegetation covered habitats via hook-and-line fishing, electrofishing, baited minnow traps, and the sampling of plant roots over a thirteen-month …

Computational Fluid Dynamics Modeling Of Internal Wave Interactions On Conch Reef, Florida Keys, Megan Miller

All HCAS Student Capstones, Theses, and Dissertations

Internal waves breaking on continental shelves play a significant role in mixing and nutrient delivery to coral reef ecosystems. As internal solitary waves, or solitons, propagate shoreward onto continental slopes, they can become unstable and break into turbulent bores that bring cool, nutrient-rich sub-thermocline water shoreward onto coral reefs. The propagation of turbulent bores generated by internal waves interacting with a complex surface creates high-frequency variabilities in the thermal and nutrient environment of Conch Reef in the Florida Keys, which has been studied previously. Here, I have created a three-dimensional model using ANSYS Fluent Computational Fluid Dynamics (CFD) software to …

Restoration Of Stony Coral Tissue Loss Disease Susceptible Species In The Arrecife De Puerto Morelos National Park, Mexico Using Colony Microfragmentation, Marina Garmendia

All HCAS Student Capstones, Theses, and Dissertations

The Arrecife de Puerto Morelos National Park (APMNP) has been a marine protected area in Mexico’s Mesoamerican Reef since 1998 and includes ~90 km² of coral reef. Significant declines in stony coral cover have been recorded within the APMNP, primarily due to increasing ocean temperatures and disease events which precipitated the need for active restoration activities. This study addressed if current APMNP conditions, in relation to Stony Coral Tissue Loss Disease (SCTLD), are appropriate for the restoration of stony corals through outplanting SCTLD-susceptible species microfragments. In September 2022, three species (Montastraea cavernosa, Orbicella annularis, and O. faveolata) …

Visual Imagery Subcategories And Their Neural Associations, Miguel Ibarguren

Undergraduate Scholarship and Creative Works

This literature review compiles research findings related to the brain areas associated with various visual imagery subcategories and explores their contributions to them. Through a search procedure, four research projects were used to identify ten distinct brain areas that demonstrated greater involvement in visual imagery. The visual imagery subcategories discussed in these research projects, and investigated in this review, include scene construction, episodic memory, imagery vividness, and visuospatial imagery. Scene construction was found to utilize the parahippocampal gyrus, hippocampus, retrosplenial cortex, and posterior parietal cortex. Episodic memory involves the same areas as scene construction, but also includes the precuneus and …

Oliver Agee Catfish Neurocranium, Charlotte R. Oliver, Kristina Agee, David Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

Neurocranium from 10.7 cm total length, [Catfish], collected by [Kerstetter].

Occupational And Environmental Factors Influencing Morale Of United States Federal Wildland Firefighters, Rachel M. Granberg, Ting Shen, Seth W. Pearson, Robin M. Verble

Psychological Science Faculty Research & Creative Works

Background. Wildland firefighters have physically and psychologically demanding jobs that can result in social, economic and health-related stress. Previous studies have examined the physiological and physical effects of a career in wildland fire, but fewer studies have addressed psychological effects, and to date, none have directly analyzed the hiring and work experiences of wildland firefighters. Aims. We surveyed work experiences, health and well-being, and morale of wildland firefighters, explored factors that can improve recruitment and retention, and summarized broad patterns. Methods. We conducted a voluntary anonymous survey of 708 federal wildland firefighters via an online platform over 2 months in …