Digital Commons Network^™

Harnessing Tree Soft Set And Soft Computing Techniques' Capabilities In Bioinformatics: Analysis, Improvements, And Applications, Mona Gharib, Fatima Rajab, Mona Mohamed

Neutrosophic Sets and Systems

No abstract provided.

Characterization Of 3d Printed Lattice Structures Used In The Design Of Modified Compression Release Stabilized Transhumeral Prosthetic Sockets, Jade Myers

Theses

Abstract A prosthetic socket is the critical interface between a person and their prosthetic device. Pressure, shear, and friction experienced by the residual limb from wearing a socket can damage soft tissue. While Compression Release Stabilized (CRS) style sockets are beneficial for enhancing prosthesis stability, range of motion, and control, the abrupt differences in compression throughout the socket present risks for tissue damage to the residual limb. A socket design that enables clinicians to control a progressive decrease in firmness in the transition areas between compression and release could mitigate such undesirable effects. Density-graded lattice structures designed and produced with …

Targeted Therapeutic Strategies For Melanoma, Shiwei Zhang, Ruxin Xie, Ai Zhong, Junjie Chen

Faculty, Staff and Student Publications

Melanoma accounts for a small proportion of skin cancers diagnosed each year, but it has a high degree of malignancy and rapid progression, resulting in a short survival period for patients. The incidence of melanoma continues to rise, and now melanoma accounts for 1.7% of cancer diagnoses worldwide and is the fifth most common cancer in the United States. With the development of high-throughput sequencing technologies, the understanding of the pathophysiology of melanoma had also been improved. The most common activating mutations in melanoma cells are BRAF , NRAS , and KIT mutations, which disrupt cell signaling pathways related to …

An Overview Of Neutrosophic Theory In Medicine And Healthcare, Ahmed K. Essa, Ramiz Sabbagh, A. A. Salama, Huda E. Khalid, Abdul-Aziz A. Aziz, Ahmed A. Mohammed

Neutrosophic Sets and Systems

No abstract provided.

The Role Of Young Architects As Entrepreneurship Generational Units In Shaping The Future Of Architecture, Attaa H. Al Obaidi, Anwar. S. Al-Qaraghuli

Al-Esraa University College Journal for Engineering Sciences

Youth are the pillar of nations and the secret of their renaissance, thebuilders of their civilization and the line of defense, the main participants inbasic planning processes, and the agents of change to build a world that iscompatible with the aspirations of future generations. This applies to the field ofarchitecture in terms of the importance of young architects in shaping it underthe challenges it faces, which impose interaction in a manner commensuratewith the emerging requirements and needs. This research is based on theconsideration that young architects are an integrated phenomenon thatcontributes to shaping architectural production according to the data of …

Nanoparticles Used In Treatment And Diagnosis Of Leishmaniasis In Iraq: A Review, Harith S. Al-Warid, Layla M. Hasan

Al-Esraa University College Journal for Medical Sciences

The aim of this paper is to identify Nano-particles that have been used in diagnosis and treatment of leishmaniasis in Iraq. All experiments conducted in this field were based on the following nanoparticles: gold nanoparticles, silver nanoparticles, zinc nanoparticles, and sodium chloride nanoparticles. Most of these experiments were reviewed in terms of differences in the concentrations of nanoparticles and the method that was used in the experiments whether it was in vivo or in vitro. These particles used in most experiments succeeded in inhibiting the growth of Leishmania parasites.

Cariesthe Effect Of Sweet Taste Perception On Dental Caries Experience In Relation To Age And Gender In Primary School Children, Mohammed H. Abdulaziz, Suha T. Abd

Al-Esraa University College Journal for Medical Sciences

This study aims to investigate the impact of sweet taste perception (sweet taste threshold and preference) on dental caries experience in relation to age and gender among a sample of schoolchildren. The research follows a cross-sectional observational design and includes 181 schoolchildren of both genders aged between 6 and 12 years from the Al-Risafa district of Baghdad city. The participants were divided into two age groups (6-8 and 9-12). Dental caries were assessed using the decayed, missing, and filled indices for primary and permanent teeth (dmfs, dmft, DMFS, and DMFT). Additionally, the sweet taste threshold and sweet taste preference were …

Determination The Effect Of Glucose On Btp, Lfabp Levels In The Patients With Diabetic Nephropathy, Zahraa Khalid Mahmood, Suhayr Aesa Al-Qaysi, Alaa Jafear Mahrath

Al-Esraa University College Journal for Medical Sciences

Everywhere in the globe, kidney illness is becoming more common, and there is no medication that can stop the progression of chronic kidney disease to end-stage renal disease, which is extremely expensive. Diabetes, kidney stones, accidents, and bleeding are the main contributors to kidney disease. The study was designed as a case control study. The study was involved (80) participants, only (36) were involved in this study and divided into two groups patients with nephropathy (23) and diabetic nephropathy (13) with age (20-65years) and BMI (19 -29 kg/m2). All these patients were diagnosed by nephrologist conducted in nephrology Clinic at …

Genetic Polymorphisms Of Aqp1 Rs10244884 Associated With Iron Deficiency Anemia In Baghdad City, Sawsan Hashim Hoshe, Moead E. Al Gazally, Hussein Naji Al-Shammari

Al-Esraa University College Journal for Medical Sciences

Most people throughout the world suffer from iron deficiency anemia (IDA). The morbidity rate is relatively high for such a complicated illness. Importantly, it has been identified that the aquaporin-1 polymorphism rs10244884 plays a critical role in iron homeostasis in the human body. The rs10244884 (T > C) polymorphism is significantly associated with iron levels and a variety of blood factors, leading to iron deficiency anemia (IDA). Venous blood samples were collected from (100) people in this analytical (case and control) investigation, including (50) patients with iron deficiency anemia and (50) healthy volunteers as a control group. The following parameters were …

Risk Detection Of Gestational Diabetes In Early Pregnancy Depend On Artificial Neural Network, Sanaa Hammad Dhahi

Al-Esraa University College Journal for Engineering Sciences

Early prediction of gestational diabetes mellitus (GDM) risk is particularly important because it may enable more effective interventions and reduce cumulative maternal and fetal injury. The aim of this study is to develop machine learning (ML) models for early prediction of GDM using widely available variables, facilitating early intervention, and enabling the application of prediction models in settings where more complex tests are not accessible. In this paper, an artificial neural network (ANN) was used to detect the risk of gestational diabetes. A global dataset was used to collect clinical and experimental data from pregnant women and people with diabetes …

Analysis Of Drug Diffusion In Human Connective Tissue In Neutrosophic Environment, Supriya Mukherjee, Ashish Acharya, Animesh Mahata, Subrata Paul, Said Broumi, Banamali Roy

Neutrosophic Sets and Systems

No abstract provided.

Multi-Attribute Group Decision-Making Based On Aggregation Operator And Score Function Of Bipolar Neutrosophic Hypersoft Environment, Faisal Al-Sharqi, Ashraf Al-Quran, Zahari Md. Rodzi

Neutrosophic Sets and Systems

No abstract provided.

Waste To Energy Treatment For India Using Critic-Waspas Method Under Interval-Valued Pythagorean Neutrosophic Fuzzy Set, R.Narmada Devi, S. Sowmiya, R. Sundareswaran, Said Broumi

Neutrosophic Sets and Systems

No abstract provided.

The Concise Guide To Pharmacology 2023/24: Catalytic Receptors, Stephen P.H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Annie Beuve, Peter Brouckaert, Clare Bryant, John C. Burnett, Richard W. Farndale, Andreas Friebe, John Garthwaite, Adrian J. Hobbs, Gavin E. Jarvis, Doris Koesling, Michaela Kuhn, David Macewan, Tom P. Monie, Lincoln R. Potter, Michael Russwurm, Harald H.H.W. Schmidt, Johannes-Peter Stasch, Scott A. Waldman

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and nearly 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org/), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It …

Effects Of Episodic Food Insecurity On Psychological And Physiological Responses In African American Women With Obesity (Responses): Protocol For A Longitudinal Observational Cohort Study, Candice A. Myers, Robbie A. Beyl, Daniel S. Hsia, Melissa N. Harris, Isabella J. Reed, Danielle D. Eliser, Lauren Bagneris, John W. Apolzan

School of Public Health Faculty Publications

Background; Food insecurity is a risk factor for multiple chronic diseases, including obesity. Importantly, both food insecurity and obesity are more prevalent in African American women than in other groups. Furthermore, food insecurity is considered a cyclic phenomenon, with episodes of food adequacy (ie, enough food to eat) and food shortage (ie, not enough food to eat). More research is needed to better understand why food insecurity is linked to obesity, including acknowledging the episodic nature of food insecurity as a stressor and identifying underlying mechanisms. Objective; The objective of this study is to investigate the episodic nature of food …

The Potential For Development Of Clinically Relevant Microbial Resistance To Rifaximin-Α: A Narrative Review, Herbert L Dupont

Faculty, Staff and Student Publications

Rifaximin-α is a gut-targeted antibiotic indicated for numerous gastrointestinal and liver diseases. Its multifaceted mechanism of action goes beyond direct antimicrobial effects, including alterations in bacterial virulence, cytoprotective effects on host epithelial cells, improvement of impaired intestinal permeability, and reduction of proinflammatory cytokine expression via activation of the pregnane X receptor. Rifaximin-α is virtually non-absorbed, with low systemic drug levels contributing to its excellent safety profile. While there are high concentrations of drug in the colon, low water solubility leads to low colonic drug bioavailability, protecting the gut microbiome. Rifaximin-α appears to be more active in the bile-rich small bowel. …

Innovation And Practice On Biodiversity Conservation In Sanjiangyuan National Park, Xinquan Zhao, Shixiao Xu, Liang Zhao, Tongzuo Zhang, Linyong Hu, Qi Li, Tongqing Guo

Bulletin of Chinese Academy of Sciences (Chinese Version)

Sanjiangyuan National Park, is one of the first batch of national parks in China, and serves as the largest national park in China. As an important ecological security barrier and a alpine biological germplasm resource base, it has significant conservation value in China and even in the world. Lots of protocols have been taken aiming at ecological tacking protection issues including loss of biodiversity and wildlife habitats, degradation of alpine grassland and overgrazing in Sanjiangyuan National Park. It promotes the implementation of major ecological restoration projects, and has formed the Sanjiangyuan National Park Biodiversity Conservation and Ecological Protection Program with …

Atmospheric 14Co2 Observation: A Novel Method To Evaluate Carbon Emissions, Zhenchuan Niu, Peng Wang, Shugang Wu, Weijian Zhou

Bulletin of Chinese Academy of Sciences (Chinese Version)

As an important carbon emitter, China faces the stress of carbon peaking and carbon neutrality goals and international carbon reduction duty. The accurate data of carbon emissions are important to evaluate the carbon peaking and carbon neutrality goals and fulfill the international duty of carbon reduction. The Intergovernmental Panel on Climate Change (IPCC) report recommends the combination of top-down atmospheric CO₂ observation with atmospheric inversion to verify the bottom-up inventory of carbon emissions, and the atmospheric ¹⁴CO₂ observation can make the verification more accurate. Radiocarbon (14C) is the most precise tracer of fossil fuel CO₂ and …

Ten Problems And Solutions For Restoration Of Karst Ecosystem In Southwest China, Xiaoyong Bai, Sirui Zhang, Chen Ran, Luhua Wu, Chaochao Du, Lei Dai, Xingyi Yang, Zilin Li, Yingying Xue, Mingkang Long, Minghui Li, Shu Yang, Qing Luo, Xiaoyun Zhang, Xiaoqian Shen, Fei Chen, Qin Li, Yuanhong Deng, Zeyin Hu, Chaojun Li

Bulletin of Chinese Academy of Sciences (Chinese Version)

The karst areas in southwest China are one of the key but difficult areas targeted in the “Beautiful China” construction initiative, which focuses on soil erosion, proportion of farmland, water pollution, karst drought, ecological restoration, carbon sink, ecological effects of urbanization, rocky desertification management indicators, and biodiversity and sustainability assessment. The study synthesizes the knowledge accumulated during ecological restoration practice in karst areas into 10 problems and solutions that are strong, universal and empirically supported. These problems and solutions help to explain the challenges of achieving sustainability in karst ecology restoration and thus point to solutions. They constitute a core …

Control Of Invasive Plant Spartina Alterniflora: Concept, Technology And Practice, Baohua Xie, Guangxuan Han

Bulletin of Chinese Academy of Sciences (Chinese Version)

Alien Species Spartina alterniflora occupy the living space of native animals and plants, and lead to the reduction of biodiversity in the intertidal zone and wetland ecological service functions. Therefore, it is urgent to curb the rapid expansion of S. alterniflora in China’s coastal areas. This paper introduced the invasion situation and main ecological hazards of S. alterniflora in China, as well as put forward the concept of S. alterniflora control of “hazard assessment – zoning control – monitoring and early warning”. We summarized the control technologies of S. alterniflora at home and abroad and the current situation of S. …

Conception On Asian Elephant Ecological Corridor Planning With Implications For Conservation, Xueyou Li, Qiupeng Yu, Zhechang Hu, Xuelong Jiang

Bulletin of Chinese Academy of Sciences (Chinese Version)

In order to practice the concept of coordinated development of “Lucid Waters and Lush Mountains are Invaluable Assets” and “mountains, rivers, forests, farmlands, lakes, grasslands and deserts are part of the community of life”, this study takes “pursuing green development and promoting harmony between humanity and nature” proposed in the report of the 20th National Congress of the Communist Party of China as the theoretical guidance. With the goal of enhancing ecosystem integrity and connectivity, enhancing population communication, enhancing population viability, and providing a model for the construction of ecological corridors for flagship species, based on the current distribution and …

Research On Geographical Landscape Design Of Ecological Civilization Construction In China, Wenzhong Zhang, Jianhui Yu

Bulletin of Chinese Academy of Sciences (Chinese Version)

As the fundamental goal of ecological civilization construction in the new era of China, the building of a Beautiful China is an important measure to promote the study of Chinese man-land relationships to a higher level and a new stage of development. This study takes the construction of ecological civilization of Beautiful China as the orientation, and carries on the frame design to the geographical landscape. The geographical landscape takes the elements of geoscience as the research object and makes a series of reasonable outlook about man-land system according to the interaction mechanism of human-land relationship and the influence of …

Impacts, Contributing Factors And Countermeasures Of Extreme Droughts In Poyang Lake, Qi Zhang, Chenyang Xue, Jun Xia

Bulletin of Chinese Academy of Sciences (Chinese Version)

In the past 20 years, the hydrological regime of Poyang Lake changed significantly. The lake water level has been continuously decreasing, resulting in severe droughts. In particular, an extreme drought occurred in 2022, when the lake area shrank to less than 300 km2. The 2022 extreme drought in Poyang Lake had great impacts on economy, society and ecological environment, which aroused great attentions and wide concerns. Based on long-term data series of meteorological and hydrological data and the existing research outcomes and with the aid of hydrological modeling, this study analyzed the impacts and contributing factors of the 2022 drought …

Stereotactic Mr-Guided On-Table Adaptive Radiation Therapy (Smart) For Borderline Resectable And Locally Advanced Pancreatic Cancer: A Multi-Center, Open-Label Phase 2 Study, Michael Chuong, Percy Lee, Daniel Low, Joshua Kim, Kathryn Mittauer, Michael Bassetti, Carri Glide-Hurst, Ann Raldow, Yingli Yang, Lorraine Portelance, Kyle Padgett, Bassem Zaki, Rongxiao Zhang, Hyun Kim, Lauren Henke, Alex Price, Joseph Mancias, Christopher Williams, John Ng, Ryan Pennell, M Raphael Pfeffer, Daphne Levin, Adam Mueller, Karen Mooney, Patrick Kelly, Amish Shah, Luca Boldrini, Lorenzo Placidi, Martin Fuss, Parag Jitendra Parikh

Department of Radiation Oncology Faculty Papers

BACKGROUND AND PURPOSE: Radiation dose escalation may improve local control (LC) and overall survival (OS) in select pancreatic ductal adenocarcinoma (PDAC) patients. We prospectively evaluated the safety and efficacy of ablative stereotactic magnetic resonance (MR)-guided adaptive radiation therapy (SMART) for borderline resectable (BRPC) and locally advanced pancreas cancer (LAPC). The primary endpoint of acute grade ≥ 3 gastrointestinal (GI) toxicity definitely related to SMART was previously published with median follow-up (FU) 8.8 months from SMART. We now present more mature outcomes including OS and late toxicity.

MATERIALS AND METHODS: This prospective, multi-center, single-arm open-label phase 2 trial (NCT03621644) enrolled 136 …

Research Priorities For Children’S Cancer: A James Lind Alliance Priority Setting Partnership In The Uk, Susie Aldiss, Rachel Hollis, Bob Phillips, Ashley Ball-Gamble, Alex Brownsdon, Julia Chisholm, Scott Crowther, Rachel Dommett, Jonathan Gower, Nigel J Hall, Helen Hartley, Jenni Hatton, Louise Henry, Loveday Langton, Kirsty Maddock, Sonia Malik, Keeley Mcevoy, Jessica Elizabeth Morgan, Helen Morris, Simon Parke, Sue Picton, Rosa Reed-Berendt, Dan Saunders, Andy Stewart, Wendy Tarplee-Morris, Amy Walsh, Anna Watkins, David Weller, Faith Gibson

Faculty, Staff and Student Publications

OBJECTIVES: To engage children who have experienced cancer, childhood cancer survivors, their families and professionals to systematically identify and prioritise research questions about childhood cancer to inform the future research agenda.

DESIGN: James Lind Alliance Priority Setting Partnership.

SETTING: UK health service and community.

METHODS: A steering group oversaw the initiative. Potential research questions were collected in an online survey, then checked to ensure they were unanswered. Shortlisting via a second online survey identified the highest priority questions. A parallel process with children was undertaken. A final consensus workshop was held to determine the Top 10 priorities.

PARTICIPANTS: Children and …

Bacterial Outer Membrane Vesicles Provide An Alternative Pathway For Trafficking Of Escherichia Coli O157 Type Iii Secreted Effectors To Epithelial Cells, Natalie Sirisaengtaksin, Eloise J O'Donoghue, Sara Jabbari, Andrew J Roe, Anne Marie Krachler

Faculty, Staff and Student Publications

Outer membrane vesicles (OMVs) are proteoliposomes shed by Gram-negative bacteria. Their secretion is enhanced by the transition into the intra-host milieu, and OMVs play critical roles during pathogenesis. Enterohemorrhagic Escherichia coli O157 (EHEC) can cause diarrheal disease in humans, and soluble toxins including Shiga-like toxins that contribute to disease severity and clinical complications like hemolytic uremic syndrome have been shown to be OMV associated. In addition to Shiga-like toxins, EHEC produces a type III secretion system (T3SS), and T3SS effectors are associated with colonization and disease severity in vivo. Here, we show that type III secreted substrates including translocators …

Colonization Of Larval Zebrafish (Danio Rerio) With Adherent-Invasive Escherichia Coli Prevents Recovery Of The Intestinal Mucosa From Drug-Induced Enterocolitis, Erika Flores, Soumita Dutta, Rachel Bosserman, Ambro Van Hoof, Anne-Marie Krachler

Faculty, Staff and Student Publications

Although inflammatory bowel diseases are on the rise, what factors influence IBD risk and severity, and the underlying mechanisms remain to be fully understood. Although host genetics, microbiome, and environmental factors have all been shown to correlate with the development of IBD, cause and effect are difficult to disentangle in this context. For example, AIEC is a known pathobiont found in IBD patients, but it remains unclear if gut inflammation during IBD facilitates colonization with AIEC, or if AIEC colonization makes the host more susceptible to pro-inflammatory stimuli. It is critical to understand the mechanisms that contribute to AIEC infections …

Exploring The Relationships Between Psychological Variables And Loot Box Engagement, Part 1: Pre-Registered Hypotheses, James Close, Stuart Gordon Spicer, Laura Louise Nicklin, Maria Uther, Ben Whalley, Chris Fullwood, Jonathan Parke, J Lloyd, H Lloyd

Peninsula Medical School

Loot boxes are purchasable randomized rewards in video games that share structural and psychological similarities with gambling. Systematic review evidence has established reproducible associations between loot box purchasing and both problem gambling and problem video gaming, perhaps driven by a range of overlapping psychological processes (e.g. impulsivity, gambling-related cognitions, etc.) It has also been argued that loot box engagement may have negative influences on player financial and psychological wellbeing. We conducted a pre-registered survey of 1495 loot box purchasing gamers (LB cohort) and 1223 gamers who purchase other, non-randomized game content (nLB cohort). Our survey confirms 15 of our 23 …

Storage Protein Activator Controls Grain Protein Accumulation In Bread Wheat In A Nitrogen Dependent Manner, Anne Plessis, Catherine Ravel, Thierry Risacher, Nathalie Duchateau, Mireille Dardevet, Marielle Merlino, François Torney, Pierre Martre

School of Biological and Marine Sciences

The expression of cereal grain storage protein (GSP) genes is controlled by a complex network of transcription factors (TFs). Storage protein activator (SPA) is a major TF acting in this network but its specific function in wheat (Triticum aestivum L.) remains to be determined. Here we generated an RNAi line in which expression of the three SPA homoeologs was reduced. In this line and its null segregant we analyzed GSP accumulation and expression of GSP and regulatory TF genes under two regimes of nitrogen availability. We show that down regulation of SPA decreases grain protein concentration at maturity under low …

Rapidiron Trial Follow-Up Study - The Rapidiron-Kids Study: Protocol Of A Prospective Observational Follow-Up Study, Richard Derman, Roopa Bellad, Mrutyunjaya Bellad, Jesse Bradford-Rogers, Michael Georgieff, Zubair Aghai, Simal Thind, Michael Auerbach, Rupsa Boelig, Benjamin Leiby, Vanessa Short, S. Yogeshkumar, Umesh Charantimath, Manjunath Somannavar, Ashalata Mallapur, Ramesh Pol, Umesh Ramadurg, Radha Sangavi, Basavaraj Peerapur, Nasima Banu, Praveen Patil, Amaresh Patil, Subarna Roy, Phaniraj Vastrad, Dennis Wallace, Hemang Shah, Shivaprasad Goudar

Global Health Articles

BACKGROUND: Anemia is a worldwide problem with iron deficiency being the most common cause. When anemia occurs in pregnancy, it increases the risk of adverse maternal, fetal, and postnatal outcomes. It induces preterm births and low birth weight (LBW) deliveries, long-term neurodevelopmental sequelae, and an increased risk of earlier onset of postnatal iron deficiency. Anemia rates are among the highest in South Asia, and India's National Family Health Survey (NFHS-5) for 2019-2021 indicated that over half of pregnant women, and more than 65% of children, in the country are classified as anemic (Sciences IIfP, National Family Health Survey-5, 2019-21, India …