Digital Commons Network^™

Sharing Pathogen Sequence Data For Global Scientific Research Under The Nagoya Protocol To The Convention On Biological Diversity, Jerome H. Reichman, Carolina Dos S. Ribeiro, George B. Haringhuizen, Paul F. Uhlir

Faculty Scholarship

The Nagoya Protocol to the Convention on Biological Diversity (CBD) has threatened to impede access to genetic resources and related data for cross-border scientific research. In principle, every use of genetic resources would require a set of contracts under the CBD, in a “bilateral” regime. The related transaction costs could overwhelm many transnational research undertakings, affecting even public health responses to outbreaks and epidemics. However, the Nagoya Protocol also offers a unique opportunity to resolve this dilemma, despite struggles to define the meaning and coverage of “digital sequence information.” The coverage of genetic sequence data under the CBD remains controversial …

Problems In Chemical Graph Theory Related To The Merrifield-Simmons And Hosoya Topological Indices, William B. O'Reilly

College of Graduate Studies: Theses & Dissertations

In some sense, chemical graph theory applies graph theory to various physical sciences. This interdisciplinary field has significant applications to structure property relationships, as well as mathematical modeling. In particular, we focus on two important indices widely used in chemical graph theory, the Merrifield-Simmons index and Hosoya index. The Merrifield-Simmons index and the Hosoya index are two well-known topological indices used in mathematical chemistry for characterizing specific properties of chemical compounds. Substantial research has been done on the two indices in terms of enumerative problems and extremal questions. In this thesis, we survey known extremal results and consider the generalized …

The Application Of Protease In Aquaculture: Prospects For Enhancing The Aquafeed Industry, Shiyou Chen, Sahya Maulu, Jie Wang, Xiaoze Xie, Xiaofang Liang, Hao Wang, Junjun Wang, Min Xue

School of Biological and Marine Sciences

Low-fishmeal and protein-saving diets are two prominent nutritional strategies utilized to address challenges related to the scarcity and sustainability of protein sources in aquaculture. However, these diets have been associated with adverse effects on the growth performance, feed utilization, and disease resistance of aquatic animals. To mitigate these challenges, exogenous protease has been applied to enhance the quality of diets with lower protein contents or fishmeal alternatives, thereby improving the bioavailability of nutritional ingredients. Additionally, protease preparations were also used to enzymatically hydrolyze fishmeal alternatives, thus enhancing their nutritional utilization. The present review aims to consolidate recent research progress on …

Sediment Sorting Within A Relatively Wave-Exposed And Sandy Subtidal Seagrass (Zostera Marina) Meadow, Gerd Masselink, Tom Brown, Tim Scott, Liane Brodie

School of Biological and Marine Sciences

Seagrasses impact on sedimentary intertidal and subtidal ecosystems by affecting local hydrodynamics, geomorphology and sediment properties. Their influence on hydrodynamics is to reduce flow velocities in their canopies, and this leads to increased net sedimentation rates and reduction of the grain size. Most investigations of the seagrass-hydrodynamics-sediment feedback system has been carried out over silt and fine-sand beds under tide-dominated conditions, mostly in the intertidal zone. Here, we use sedimentological data from a relatively wave-exposed and subtidal seagrass (Zostera marina) meadow in the Isles of Scilly with a fine-to-medium sand bed and show that the sand within the seagrass meadow …

Taking Sides? Aspect Has Limited Influence On Soil Environment Or Litter Decomposition In Pan-European Study Of Roadside Verges, A. Amstutz, L. B. Firth, J. I. Spicer, P. De Frenne, L. Gómez-Aparicio, B. J. Graae, S. Kuś, S. Lindmo, A. Orczewska, F. Rodríguez-Sánchez, P. Vangansbeke, T. Vanneste, M. E. Hanley

School of Biological and Marine Sciences

In addition to well-known effects on species ecophysiology, phenology, and distributions, climate change is widely predicted to impact essential ecosystem services such as decomposition and nutrient cycling. While temperature and soil moisture are thought to influence litter decomposition, elucidating consistent soil process responses to observed or predicted shifts in climate have proven difficult to evidence. Here we investigated how aspect (i.e., north-south orientation), a natural model for variation in soil temperature, influenced soil physico-chemical conditions and decomposition of two standardised litter types (Green tea and Rooibos teabags) in Pole-facing (PF) and Equator-facing (EF) roadside verges spanning a 3000 km and …

The North–South Divide? Macroalgal Functional Trait Diversity And Redundancy Varies With Intertidal Aspect, Axelle Amstutz, Louise B. Firth, Andy Foggo, John I. Spicer, Mick E. Hanley

School of Biological and Marine Sciences

Background and Aims Marine macroalgae (‘seaweeds’) are critical to coastal ecosystem structure and function, but also vulnerable to the many environmental changes associated with anthropogenic climate change (ACC). The local habitat conditions underpinning observed and predicted ACC-driven changes in intertidal macroalgal communities are complex and probably site-specific and operate in addition to more commonly reported regional factors such as sea surface temperatures. Methods We examined how the composition and functional trait expression of macroalgal communities in SW England varied with aspect (i.e. north–south orientation) at four sites with opposing Equator- (EF) and Pole-facing (PF) surfaces. Previous work at these sites …

Episodic Memory Assessment: Effects Of Sex And Age On Performance And Response Time During A Continuous Recognition Task, James O. Clifford, Sulekha Anand, Franck Tarpin-Bernard, Michael F. Bergeron, Curtis B. Ashford, Peter J. Bayley, John Wesson Ashford

Faculty Research, Scholarly, and Creative Activity

Introduction: Continuous recognition tasks (CRTs) assess episodic memory (EM), the central functional disturbance in Alzheimer’s disease and several related disorders. The online MemTrax computerized CRT provides a platform for screening and assessment that is engaging and can be repeated frequently. MemTrax presents complex visual stimuli, which require complex involvement of the lateral and medial temporal lobes and can be completed in less than 2 min. Results include number of correct recognitions (HITs), recognition failures (MISSes = 1-HITs), correct rejections (CRs), false alarms (FAs = 1-CRs), total correct (TC = HITs + CRs), and response times (RTs) for each HIT and …

Bibliography Of Scholarship From 2024, University Of San Diego

Annual Bibliography of USD Scholarship

No abstract provided.

Translation Of: Trembley À Réaumur, Abraham Trembley, Morgan Mclaughlin

Biology: Student Scholarship & Creative Works

While examining a jar filled with aquatic plants and animals, Abraham Trembley, a young tutor working for Count William Bentinck in the Netherlands, noticed tiny, green, tube-shaped organisms attached to aquatic plants. Uncertain whether they were plants or animals, he devised a brilliant series of experiments to understand their biology. He observed them contract when disturbed and take steps towards a light, gathering in front of a chevron-shaped opening in a piece of cardboard. Nearly convinced they were animals, he cut one in half expecting to see it die. Instead, it regenerated two perfectly formed bodies from the severed halves. …

Coleoptera Of Brazil: What We Knew Then And What We Know Now. Insights From The Catálogo Taxonômico Da Fauna Do Brasil, Edilson Caron, Marcela L. Monné, Geoffrey Morse, Et Al.

Biology: Faculty Scholarship

In 2000, Cleide Costa published a paper presenting the state of knowledge of the Neotropical Coleopte ra, with a focus on the Brazilian fauna. Twenty-four years later, thanks to the development of the Coleoptera section of the Taxonomic Catalog of the Brazilian Fauna (CTFB - Catálogo Taxonômico da Fauna do Brasil) through the collaboration of 100 coleopterists from all over the globe, we can build on Costa’s work and present an updated overview of the state of knowledge of the beetles from Brazil. There are currently 35,699 species in 4,958 genera and 116 families known to occur in the country, …

An Overview Of The Brazilian Chrysomelidae (Insecta: Coleoptera): The Most Species-Rich Beetle Family In Brazil, Adelita M. Linzmeier, Luciano De A. Moura, Cibele S. Ribeiro-Costa, Daiara Manfio, Federico Agrain, Maria L. Chamorro, Geoffrey Morse, Renato Regalin, Lukáš Sekerka

Biology: Faculty Scholarship

The leaf beetles (Chrysomelidae) are one of the most species-rich family of herbivorous beetles with about 45,000 species worldwide. Based on the contributions of chrysomelidologists to the Taxonomic Catalog of the Brazilian Fauna - CTFB, the family comprises 6,079 species in 562 genera of which 951 species are endemic to Brazil, standing out as the most diverse, representing 4.8% of the Brazilian fauna and 17.1% of the beetle species. Chrysomelidae has twelve subfamilies with nine reported to Brazil: Galerucinae, the richest with 1,916 species in 202 genera, followed by Cassidinae, Eumolpinae, Cryptocephalinae, Chrysomelinae, Bruchinae, Criocerinae, Lamprosomatinae and Sagrinae - this …

Amplifying Pcr Productivity And Environmental Sustainability Through Shortened Cycling Protocols, Matthew Pedlar, Matthew J. Emery, Philip J. Warburton

School of Biological and Marine Sciences

Since its inception in the 1980s, advancements in PCR technology using improved thermal cyclers, engineered DNA polymerases and commercial master mixes, have led to increased PCR productivity. Despite these advancements, PCR cycling protocols have largely remained unchanged over the same period. This study aimed to systemically evaluate the effect of reduced PCR cycling parameters on amplicon production. The 1466bp fragment from the 16S rRNA gene present in low-, medium- and high-CG bacteria was amplified using three commercially available PCR master mixes. The shortest cycling parameters required to successfully amplify the 16S fragment from all bacteria and master mixes comprised 30-cycles …

Shifting The Focus From Species To Individuals In Invasion Biology: Individual Differences In Jumping Behaviour, Aaron Jessop, Miguel Barbosa, Michael Morrissey

School of Biological and Marine Sciences

Dispersal is critical to population persistence, colonization and connectivity which are all critical components of invasive success. While individual propensity to disperse varies within populations, the underlying mechanisms promoting individual dispersal remain unclear. Collectively, dispersal is influenced by the environment and individual phenotype. Here we investigated individual dispersal propensity in the Trinidadian guppy, Poecilia reticulata, and related individual variation in dispersal behaviour to phenotype and social/environmental conditions. Namely, we addressed the effect of sex ratio (social/environmental factor) on the tendency for individuals to disperse across physical barriers via jumping behaviour. Jumping is vital for the dispersal of many aquatic species …

Emigration Of Post-Spawned Twaite Shad Alosa Fallax, An Anadromous And Iteroparous Fish, In A Highly Fragmented River, Mark I.A. Yeldham, J. Robert Britton, Charles Crundwell, Peter Davies, Jamie R. Dodd, Andrew D. Nunn, Randolph Velterop, Jonathan D. Bolland

School of Biological and Marine Sciences

Anthropogenic barriers are widely known to negatively impact the spawning migrations of anadromous fishes, by delaying or preventing passage upstream. Although the impacts of barriers on emigrating post-spawned adults are less well studied, they could potentially impact the fitness and subsequent return rates of iteroparous species. In this study, passive acoustic telemetry was used to track the emigrations of 53 twaite shad Alosa fallax in the River Severn basin in their first spawning migration a year after being tagged, giving insights into their emigration movements and the impacts of anthropogenic weirs on these movements. A. fallax began their emigrations after …

Inconsistent Bioreceptivity Of Three Mortar Mixes In Subtidal Sites, Jessica R. Bone, Alice E. Hall, Rick Stafford, Roger J.H. Herbert

School of Biological and Marine Sciences

Concrete is extensively used in coastal engineering and development which, in addition to its high carbon footprint, threatens intertidal habitats and ecosystems. Eco-engineering addresses this by designing habitat features into coastal infrastructure. The chemical bioreceptivity of cement has been shown to vary, but ordinary Portland cement is generally considered to be the least bioreceptive. In this study, we compare two low carbon mortars (a natural, single source cement (VP), and an ordinary Portland cement/ ground granulated blast furnace slag blend (GGBS)) with an ordinary Portland cement-based control mix (OPC). The three mortars were made into smooth blocks which were secured …

Transgressive Gene Expression And Expression Plasticity Under Thermal Stress In A Stable Hybrid Zone, Lindsey C. Schwartz, Vanessa L. González, Ellen E. Strong, Manuela Truebano, Thomas J. Hilbish

School of Biological and Marine Sciences

Interspecific hybridization can lead to myriad outcomes, including transgressive phenotypes in which the hybrids are more fit than either parent species. Such hybrids may display important traits in the context of climate change, able to respond to novel environmental conditions not previously experienced by the parent populations. While this has been evaluated in an agricultural context, the role of transgressive hybrids under changing conditions in the wild remains largely unexplored; this is especially true regarding transgressive gene expression. Using the blue mussel species complex (genus Mytilus) as a model system, we investigated the effects of hybridization on temperature induced gene …

Integration Of Attractive And Defensive Phytochemicals Is Unlikely To Constrain Chemical Diversification In A Perennial Herb, Hanna Eriksdotter Thosteman, Katherine Eisen, Hampus Petrén, Sotiria Boutsi, Loretta Pace, John M. Halley, Consuelo M. De Moraes, Mark C. Mescher, James Buckley, Magne Friberg

School of Biological and Marine Sciences

Diversification of plant chemical phenotypes is typically associated with spatially and temporally variable plant–insect interactions. Floral scent is often assumed to be the target of pollinator-mediated selection, whereas foliar compounds are considered targets of antagonist-mediated selection. However, floral and vegetative phytochemicals can be biosynthetically linked and may thus evolve as integrated phenotypes. Utilizing a common garden of 28 populations of the perennial herb Arabis alpina (Brassicaceae), we investigated integration within and among floral scent compounds and foliar defense compounds (both volatile compounds and tissue-bound glucosinolates). Within floral scent volatiles, foliar volatile compounds, and glucosinolates, phytochemicals were often positively correlated, and …

Do I Sound Anxious? Emotional Arousal Is Linked To Changes In Vocalisations In Domestic Chicks (Gallus Gallus Dom.), Sarah A. Collins, Katherine Herborn, Kenneth J. Sufka, Lucy Asher, Ben Brilot

School of Biological and Marine Sciences

A major goal in animal welfare science is the development of methods that quantify or ‘read-out’ current affective states in freely behaving animals. In mammalian models, changes in acoustic parameters within vocalisations have been linked to differences in emotional arousal, although there are very few studies showing changes in vocalisations that act as indicators of valence (positive or negative affect). Currently, there are very few studies on vocal indicators of emotion in birds. To determine the link between acoustic parameters within vocalisations and emotion in domestic chicks (Gallus gallus dom.), we used a well-validated paradigm that purports to elicit two …

From Riverbank To The Sea: An Initial Assessment Of Plastic Pollution Along The Ciliwung River, Indonesia, Muhammad Reza Cordova, Max R. Kelly, Muhammad Hafizt, Singgih Prasetyo Adi Wibowo, Yaya Ihya Ulumuddin, Triyoni Purbonegoro, Deny Yogaswara, Muhammad Taufik Kaisupy, Riyana Subandi, Sofia Yuniar Sani, Richard C. Thompson, Susan Jobling

School of Biological and Marine Sciences

This study presents the first comprehensive analysis of anthropogenic debris on the riverbanks of the Ciliwung River, covering upstream to downstream areas. The mean of debris found in each measurement was 32.79 ± 15.38 items/m² with a weight of 106.00 ± 50.23 g/m². Plastic debris accounted for over 50 % of all litter items identified and represents 55 % by weight, signifying a significantly high prevalence compared to global studies examining litter along riverbanks. The majority of the plastics found originated from Single-use applications and were predominantly made from Styrofoam. This investigation demonstrated the importance of actions …

Victim Of Changes? Marine Macroalgae In A Changing World, Mick E. Hanley, Louise B. Firth, Andy Foggo

School of Biological and Marine Sciences

Background Marine macroalgae (‘seaweeds’) are a diverse and globally distributed group of photosynthetic organisms that together generate considerable primary productivity, provide an array of different habitats for other organisms, and contribute many important ecosystem functions and services. As a result of continued anthropogenic stress on marine systems, many macroalgal species and habitats face an uncertain future, risking their vital contribution to global productivity and ecosystem service provision. Scope After briefly considering the remarkable taxonomy and ecological distribution of marine macroalgae, we review how the threats posed by a combination of anthropogenically induced stressors affect seaweed species and communities. From there …

Invasive Macroalgae In Native Seagrass Beds: Vectors Of Spread And Impacts, Louise Firth, Andy Foggo, Thomas Watts, Antony Knights, Stacey Deamicis

School of Biological and Marine Sciences

Background and AimsWorldwide, invasive species are spreading through marine systems at an unprecedented rate with both positive and negative consequences for ecosystems and the biological functioning of organisms. Human activities from shipping to habitat damage and modification are known vectors of spread, although biological interactions including epibiosis are increasingly recognized as potentially important to introduction into susceptible habitats.MethodsWe assessed a novel mechanism of spread – limpets as transporters of an invasive alga, Sargassum muticum, into beds of the seagrass Zostera marina – and the physiological impact of its invasion. The association of S. muticum with three limpet species and other …

Differences In Prediagnostic Serum Metabolomic And Lipidomic Profiles Between Cirrhosis Patients With And Without Incident Hepatocellular Carcinoma, Hannah Powell, Cristian Coarfa, Elisa Ruiz-Echartea, Sandra L Grimm, Omar Najjar, Bing Yu, Luis Olivares, Michael E Scheurer, Christie Ballantyne, Abeer Alsarraj, Emad Mohamed Salem, Aaron P Thrift, Hashem B El Serag, Salma Kaochar

Faculty, Staff and Students Publications

BACKGROUND: Early detection of hepatocellular carcinoma (HCC) is crucial for improving patient outcomes, but we lack robust clinical biomarkers. This study aimed to identify a metabolite and/or lipid panel for early HCC detection.

METHODS: We developed a high-resolution liquid chromatography mass spectrometry (LC-MS)-based profiling platform and evaluated differences in the global metabolome and lipidome between 28 pre-diagnostic serum samples from patients with cirrhosis who subsequently developed HCC (cases) and 30 samples from patients with cirrhosis and no HCC (controls). We linked differentially expressed metabolites and lipids to their associated genes, proteins, and transcriptomic signatures in publicly available datasets. We used …

Trends In Cardiovascular Disease-Related Mortality In Texas, Muhammad Shariq Usman, Adeena Jamil, Zainali Chunawala, Mahboob Alam, Vijay Nambi, Layla A Abushamat, Arunima Misra, Salim S Virani, Christie M Ballantyne, George E Taffet, Khurram Nasir, Sachin Goel, Sadeer Al-Kindi, Javed Butler, Abdul Mannan Khan Minhas

Faculty, Staff and Students Publications

BACKGROUND: Cardiovascular disease (CVD) is associated with high mortality in the United States, but the burden of CVD mortality is unevenly distributed between demographic and geographic subgroups, with poor characterization of state-specific trends. In this study, the disparities in CVD-related mortality trends in Texas and the United States from 1999 to 2019 were assessed.

METHODS: Trends in CVD-related mortality were evaluated through analysis of the Multiple Causes of Death Files from the National Center for Health Statistics. Crude and age-adjusted mortality rates (AAMRs) per 100,000 population with associated annual percentage changes were determined. Joinpoint regression was used to assess trends …

Clinical Utility Of Plasma Microbial Cell-Free Dna Sequencing In Determining Microbiologic Etiology Of Infectious Syndromes In Solid Organ Transplant Recipients, Jesal R Shah, Muhammad Rizwan Sohail, Todd Lasco, John A Goss, Mayar Al Mohajer, Sarwat Khalil

Faculty, Staff and Students Publications

BACKGROUND: Metagenomic next-generation sequencing (mNGS) is increasingly being used for microbial detection in various infectious syndromes. However, data regarding the use of mNGS in solid organ transplant recipients (SOTR) are lacking.

OBJECTIVES: To describe and analyze real-world clinical impact of mNGS using plasma microbial cell-free DNA (mcfDNA) in SOTR.Design: Retrospectively reviewed all adult SOTR who underwent mNGS testing using plasma mcfDNA at Baylor St Luke's Medical Center from March 2017 to February 2023.

METHODS: Clinical impact (positive, neutral, and negative) was assessed using standardized objective criteria. Three Infectious Diseases physicians independently performed clinical adjudication to determine the correlation of mcfDNA …

Clinical Utility Of Metagenomic Next-Generation Sequencing In Fever Of Undetermined Origin, Marilyne Daher, Roumen Iordanov, Mayar Al Mohajer, M Rizwan Sohail, Kristen Andrews Staggers, Ahmed Mufeed Hamdi

Faculty, Staff and Students Publications

BACKGROUND: Metagenomic next-generation sequencing (mNGS) is a novel diagnostic tool increasingly used in the field of infectious diseases. Little guidance is available regarding its appropriate use in different patient populations and clinical syndromes. We aimed to review the clinical utility of mNGS in patients with a specific clinical syndrome and identify factors that may increase its utility.

METHODS: We retrospectively reviewed charts of 72 non-immunocompromised adults hospitalized with the clinical syndrome of 'fever of undetermined origin' and underwent mNGS testing. Standardized criteria from a previously published study were used to determine the clinical impact of mNGS testing. We applied logistic …

Detection Of Invasive Bartonella Infections With Next-Generation Sequencing Of Microbial Cell-Free Dna, Fernando H Centeno, Ahmed M Hamdi, Todd M Lasco, Mayar Al Mohajer

Faculty, Staff and Students Publications

We report 9 patients with invasive Bartonella infections, including 5 with endocarditis, who were diagnosed with microbial cell-free DNA next-generation sequencing and Bartonella serology studies. Diagnosis with plasma mcfDNA NGS enabled a faster clinical and laboratory diagnosis in 8 patients. Prompt diagnosis impacted antibiotic management in all 9 patients.

Creating A Plasma Coordination Center To Support Covid-19 Outpatient Trials Across A National Network Of Hospital Blood Banks, Anusha Yarava, Christi Marshall, David E Reichert, Aaron Ye, Preeti Khanal, Sanford H Robbins, Bruce S Sachais, David Oh, Ryan A Metcalf, Kathleen Conry-Cantilena, Karen King, Meredith Reyes, Jill Adamski, Marisa B Marques, Minh-Ha Tran, Elizabeth S Allen, Daniel Pach, Neil Blumberg, Rhonda Hobbs, Tammon Nash, Aarthi G Shenoy, Giselle S Mosnaim, Yuriko Fukuta, Bela Patel, Sonya L Heath, Adam C Levine, Barry R Meisenberg, Shweta Anjan, Moises A Huaman, Janis E Blair, Judith S Currier, James H Paxton, William Rausch, Kevin Oei, Matthew Abinante, Donald N Forthal, Martin S Zand, Seble G Kassaye, Edward R Cachay, Kelly A Gebo, Shmuel Shoham, Arturo Casadevall, Nichol A Mcbee, Daniel Amirault, Ying Wang, Erica Hopkins, David M Shade, Oliver Layendecker, Sabra L Klein, Han-Sol Park, John S Lee, Patrizio Caturegli, Jay S Raval, Daniel Cruser, Alyssa F Ziman, Jonathan Gerber, Thomas J Gniadek, Evan M Bloch, Aaron A R Tobian, Daniel F Hanley, David J Sullivan, Karen Lane

Faculty, Staff and Students Publications

INTRODUCTION: In response to the COVID-19 pandemic, we rapidly implemented a plasma coordination center, within two months, to support transfusion for two outpatient randomized controlled trials. The center design was based on an investigational drug services model and a Food and Drug Administration-compliant database to manage blood product inventory and trial safety.

METHODS: A core investigational team adapted a cloud-based platform to randomize patient assignments and track inventory distribution of control plasma and high-titer COVID-19 convalescent plasma of different blood groups from 29 donor collection centers directly to blood banks serving 26 transfusion sites.

RESULTS: We performed 1,351 transfusions in …

A Transcriptomic Biomarker Predicting Linezolid-Associated Neuropathy During Treatment Of Drug-Resistant Tuberculosis, Nika Zielinski, Dragos Baiceanu, Antonela Dragomir, Jan Heyckendorf, Elmira Ibraim, Niklas Köhler, Christoph Leschczyk, Cristina Popa, Andrea Rachow, Jens Sachsenweger, Patricia Sanchez Carballo, Dagmar Schaub, Hajo Zeeb, Begna Tulu, Andrew R Dinardo, Christoph Lange, Maja Reimann

Faculty, Staff and Students Publications

BACKGROUND: Neuropathic adverse events occur frequently in linezolid-containing regimens, some of which remain irreversible after drug discontinuation.

OBJECTIVE: We aimed to identify and validate a host RNA-based biomarker that can predict linezolid-associated neuropathy before multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) treatment initiation and to identify genes and pathways that are associated with linezolid-associated neuropathy.

METHODS: Adult patients initiating MDR/RR-TB treatment including linezolid were prospectively enrolled in 3 independent cohorts in Germany. Clinical data and whole blood RNA for transcriptomic analysis were collected. The primary outcome was linezolid-associated optic and/or peripheral neuropathy. A random forest algorithm was used for biomarker identification. The biomarker was …

Modelling The Spatial Risk Pattern Of Dementia In Denmark Using Residential Location Data: A Registry-Based National Cohort, Prince M. Amegbor, Clive E. Sabel, Laust H. Mortensen, Amar J. Mehta

School of Geography, Earth and Environmental Sciences

Dementia is a major global public health concern that is increasingly leading to morbidity and mortality among older adults. While studies have focused on the risk factors and care provision, there is currently limited knowledge about the spatial risk pattern of the disease. In this study, we employ Bayesian spatial modelling with a stochastic partial differential equation (SPDE) approach to model the spatial risk using complete residential history data from the Danish population and health registers. The study cohort consisted of 1.6 million people aged 65 years and above from 2005 to 2018. The results of the spatial risk map …

Insights From Early Career Researcher Representatives At The Sustainability Research & Innovation Congress 2022 Asia Spotlight Event, Cho Kwong Charlie Lam

School of Geography, Earth and Environmental Sciences

The Sustainability Research & Innovation Congress 2022 Asia Spotlight Event (SRI-ASE 2022) was held virtually from June 21-24, 2022 and co-organized by Future Earth Global Secretariat Hubs in Asia based in Japan, Taipei, China, and South Asia, during the main sessions of the SRI 2022. SRI-ASE 2022 included over 70 speakers and more than 300 participants from within and outside the Asia region. The aim of the event was to provide space to reflect on inspiring research and discussions related to the themes: New Horizons, Different Ways of Knowing, Nexus Issues, and Cross-cutting Science and Innovation in Asia. This report …