Digital Commons Network^™

Role Of Interferon Induced Transmembrane Protein 3 (Ifitm3) And Neural Precursor Cell Expressed Developmentally Down Regulated Protein 4 (Nedd4) In Seneca Virus A (Sva) Replication, Shamiq Aftab

Electronic Theses and Dissertations

In this study, we studied the role of IFITM3 in SVA replication in vitro by silencing the endogenous IFITM3 in NCI-H1299 cells. An average of 1.94-fold increase in SVA VP2 expression and an average of 4.4-fold increase in supernatant virus titer was observed after 24h SVA isolate SD15-26 infection. We have indeed observed an increase in viral mRNA copies by an average of 5-fold in IFITM3 silenced NCI-H1299 cells at 8 hpi indicating that IFITM3 restricts SVA replication post virus attachment and entry. A positive correlation between interferon-alpha induced IFITM3 upregulation and reduced SVA replication was observed. To further confirm …

Refining The Inverse Lipschitz Constant For Injective Relu Networks, Cole Rausch

Electronic Theses and Dissertations

In this thesis, we study the Inverse Lipschitz Constant (ILC) of injective ReLU layers. We study the tightness of the ILC lower bound established in Puthawala et al. Our approach has three components. First, we find that the conditions for injectivity on lines yield a weaker condition than the general condition given in Puthawala et al. Second, we perform numerical experiments to judge the tightness of the existing ILC lower bound and find that bound is overly conservative. Third, we identify the source of the potential slack in the proof of the existing ILC bound, and perform further numerical experiments …

Examination Of The Differences And Similarities In The Classification Of Multiple Homicide Perpetrators, Lucy M. Papp

Theses and Dissertations

The applied dissertation compares the lifestyle and behavioral characteristics of mass, serial, and spree murderers. Historically, studies have focused on serial murder according to the perpetrator's typology or indicators at the crime scene. The current topics of research lack a comparison of these classifications. While the classification and described typologies are essential for academic and investigative purposes, understanding the impactful lifestyle factors of these perpetrators may also serve as an essential factor in predictive analysis, victimology, and the motive behind their heinous crimes.

The researcher collected data on the classifications for each type of multiple homicide perpetrator: mass, serial, and …

Strategies Teachers Use To Encourage Student Reading Motivation And Engagement In The High School Setting: A Generic Qualitative Study, Shelia Tate

Theses and Dissertations

This applied dissertation was designed to provide an understanding of the practices and strategies used by Title 1 high school teachers to promote student reading motivation and engagement. Engaging students in the curriculum and motivating them to read is essential to a successful classroom experience. As districts move to a more prescribed curriculum with provided scope and sequence, teachers look for ways to engage their students and provide relevant resources to meet their students' needs creatively.

The researcher interviewed teachers to explore their beliefs, strategies, and practices for fostering student reading motivation and classroom engagement in high school. The guiding …

Female Offenders: Exploring Risk Factors For Adulthood Violence, Lauren N. Fowler

Theses and Dissertations

The number of females under correctional supervision has been increasing in the last four decades. For adult women, these offenses are generally drug offenses; however, there have also been increases in the number of women committing violent crimes. Unfortunately, violent females are an understudied population, which limits the data available to inform programs and policies that could address the problem. This study explored potential factors related to violent behavior among adult females by analyzing public-use data from the Bureau of Justice Statistics’ Survey of Prison Inmates, 2016. More specifically, violent and nonviolent state and federal female inmates were assessed regarding …

Exploring The Role Of The Teacher In Motivating Students To Learn Mathematics At Alternative High Schools, Anne-Marie Johanne Mohammed

Theses and Dissertations

The purpose of this applied dissertation was to provide an in-depth understanding of the teacher’s role in motivating students to learn mathematics at alternative high schools because motivation impacts academic achievement in mathematics. Students in South Florida must pass an end-of-course exam in algebra as a requirement to receive a high school diploma. Therefore, it is essential that students are motivated to learn the mathematics concepts that are necessary to pass the end-of-course exam. This research study was guided by the following research questions:

1. How and in what ways do mathematics teachers adjust and integrate instructional strategies to support …

Just Look At The Map: Bounding Environmental Review Of Housing Development In California, Eric Biber, Christopher S. Elmendorf, Nicholas Marantz, Moira O’Neill

Faculty Scholarship

California faces a dire housing crisis. California’s land-use regulatory system remains a key driver of this crisis. State law grants local governments broad power to craft their own regulations on how to review and approve housing development. Though state law may limit a locality’s ability to outright deny some types of housing development, local governments can and do use creative ways to stall approvals or functionally deny housing by making it infeasible to develop. One such strategy is to demand more intensive environmental review of new housing projects under the California Environmental Quality Act (CEQA) than what state law requires. …

Ai & Antitrust: The Algorithm Made Me Do It, Robin Feldman, Caroline Yuen

Faculty Scholarship

As the dawn of artificial intelligence (“AI”) rises rapidly, competition authorities should contemplate the potential for hazy days ahead. Undoubtedly, AI’s already ubiquitous presence offers exciting possibilities, from enhancing efficiency, to leveling the playing field for non-native speakers,to enabling scientific discovery.Despite these breathtaking advancements, however, recent data from the Pew Research Center reveal that only 15% of adults surveyed were “more excited than concerned about the increasing use of AI in daily life,” with 46% expressing “an equal mix of concern and excitement.”

Policymakers also manifest concerns about AI, exemplified by the extent to which government actors are racing to …

Hierarchies Of Discrimination In Baby Making? A Response To Professor Carroll, Radhika Rao

Faculty Scholarship

No abstract provided.

Paucity Of Intellectual Property Rights Information In The Us Biologics System A Decade After Passage Of The Biosimilars Act, Robin Feldman

Faculty Scholarship

No abstract provided.

The Intrusive State: Restrictions On Gender-Affirming Healthcare For Minors, Exceptions To The Doctrine Of Parental Consent, And Reliance On Science And Medical Expertise, Lois A. Weithorn

Faculty Scholarship

The provision of gender-affirming medical care to transgender or gender diverse (“TGD”) youth is currently the subject of substantial controversy despite an overwhelming consensus in the healthcare community as to the safety and potential benefits of recommended treatments. Much of the debate is fueled by misinformation and inaccurate characterization of research and practice. Against this backdrop, twenty-three states enacted restrictions or complete prohibitions on access to gender-affirming medical care for adolescents between 2021 and the time of this writing in early 2024. The policies typically place healthcare practitioners who provide such services at risk of license revocation. Some statutes create …

Regulatory Landscapes: Transcriptome And Microrna Regulated Senescence And Dormancy In Grapevines And Gene Regulatory Networks In Nitrogen-Fixing Soybean Nodules, Ramandeep Kaur

Electronic Theses and Dissertations

Grapevine and soybean are two economically important crops, each with unique yet equally crucial physiological processes that profoundly influence their growth and productivity. Grapevine (Vitis sp.), a temperate fruit crop, employs dormancy to withstand winter challenges and can grow in various regions worldwide. Understanding the molecular mechanisms involved in dormancy in Vitis species, is crucial for improving grapevine selection for resilience in northern temperate regions. Dormancy induction is modulated by decreasing photoperiods in some Vitis species, enhancing their ability to prepare for winter stress conditions. Understanding the molecular underpinnings of response to photoperiod will provide potential markers for selecting genotypes …

Underlying Substrate Effect On Electrochemical Activity For Hydrogen Evolution Reaction With Low-Platinum-Loaded Catalysts, Baleeswaraiah Muchharla, Peter V. Sushko, Kishor K. Sadasivuni, Wei Cao, Akash Tomar, Hani Elsayed-Ali, Adetayo Adedeji, Abdennaceur Karoui, Joshua M. Spurgeon, Bijandra Kumar

Electrical & Computer Engineering Faculty Publications

Platinum is known as the best catalyst for the hydrogen evolution reaction (HER) but the scarcity and high cost of Pt limit its widespread applicability. Herein, the role of the underlying substrate on the HER activity of dispersed Pt atoms is uncovered. A direct current magnetron sputtering technique is utilized to deposit transition metal (TM) thin films of W, Ti, and Ta as underlying substrates for extremely low loading of Pt (

Recent Progress In Microrna Detection Using Integrated Electric Fields And Optical Detection Methods, Logeeshan Velmanickam, Dharmakeerthi Nawarathna

Electrical & Computer Engineering Faculty Publications

Low-cost, highly-sensitivity, and minimally invasive tests for the detection and monitoring of life-threatening diseases and disorders can reduce the worldwide disease burden. Despite a number of interdisciplinary research efforts, there are still challenges remaining to be addressed, so clinically significant amounts of relevant biomarkers in body fluids can be detected with low assay cost, high sensitivity, and speed at point-of-care settings. Although the conventional proteomic technologies have shown promise, their ability to detect all levels of disease progression from early to advanced stages is limited to a limited number of diseases. One potential avenue for early diagnosis is microRNA (miRNA). …

Different Visions From Biosview: A Brief Report, Lucas N. Potter, Xavier-Lewis Palmer

Electrical & Computer Engineering Faculty Publications

In this collaborative research endeavor at the intersection of biological safety and cybersecurity for BiosView labs, the authors highlight their engagement with a diverse student cohort. The chapter delves into the motivation behind collaborations extending beyond traditional academic research environments, emphasizing inclusivity. The meticulous examination of student demographics, including gender, self-reported ethnicity, and national origin, is detailed in the methodology. A student-centric approach is central to the exploration, focusing on aligning teaching and management styles with unique student needs. The chapter elaborates on effective teaching methodologies and management practices tailored for BiosView labs. A dedicated section emphasizes the purpose of …

Wavelet-Based Harmonization Of Local And Global Model Shifts In Federated Learning For Histopathological Images, W. Farzana, A. Temtam, K. M. Iftekharuddin

Electrical & Computer Engineering Faculty Publications

Federated Learning (FL) is a promising machine learning approach for development of data-driven global model using collaborative local models across multiple local institutions. However, the heterogeneity of medical imaging data is one of the challenges within FL. This heterogeneity is caused by the variation in imaging scanner protocols across institutions, which may result in weight shift among local models leading to deterioration in predictive accuracy of global model. The prevailing approaches involve applying different FL averaging techniques to enhance the performance of the global model, ignoring the distinct imaging features of the local domain. In this work, we address both …

Paper-Based Dna Biosensor For Rapid And Selective Detection Of Mir-21, Alexander Hunt, Sri Ramulu Torati, Gymama Slaughter

Electrical & Computer Engineering Faculty Publications

Cancer is the second leading cause of death globally, with 9.7 million fatalities in 2022. While routine screenings are vital for early detection, healthcare disparities persist, highlighting the need for equitable solutions. Recent advancements in cancer biomarker identification, particularly microRNAs (miRs), have improved early detection. MiR-21 is notably overexpressed in various cancers and can be a valuable diagnostic tool. Traditional detection methods, though accurate, are costly and complex, limiting their use in resource-limited settings. Paper-based electrochemical biosensors offer a promising alternative, providing cost-effective, sensitive, and rapid diagnostics suitable for point-of-care use. This study introduces an innovative electrochemical paper-based biosensor that …

A Review Of Emerging Sensor Technologies For Tank Inspection: A Focus On Lidar And Hyperspectral Imaging And Their Automation And Deployment, Sergio Pallas Enguita, Chung-Hao Chen, Samuel Kovacic

Electrical & Computer Engineering Faculty Publications

This paper reviews various sensor technologies for tank inspection, focusing on Light Detection and Ranging (LiDAR) and Hyperspectral Imaging (HSI) as advanced solutions for corrosion detection. These technologies are evaluated alongside traditional methods such as ultrasonic, electromagnetic, and thermographic inspections. This review highlights their potential to enhance inspection accuracy, reduce the limitations of manual inspection, and support integrated data analysis for comprehensive asset management. Additionally, this paper proposes a pathway for automating these techniques to streamline inspection processes and improve implementation in practical applications.

Methylene Blue-Mediated Photodynamic Therapy In Combination With Doxorubicin: A Novel Approach In The Treatment Of Ht-29 Colon Cancer Cells, Nima Rastegar-Pouyani, Jaber Zafari, Alireza Nasirpour, Hossein Vazini, Nabbaa Najjar, Seyedeh Zohreh Azarshin, Fatemeh Javani Jouni

Electrical & Computer Engineering Faculty Publications

Introduction: With an alarmingly growing number of patients diagnosed with colorectal cancer, adopting innovative anti-cancer approaches has recently garnered great attention. One interesting concept is the co-administration of cytotoxic agents and safer modalities such as photodynamic therapy (PDT), which can subsequently improve therapeutic efficacy and potentially reduce the risks of severe adverse effects and drug resistance. In the course of PDT, a locally injected photosensitizer (PS) is irradiated with a light source, which subsequently generates reactive oxygen species (ROS) and induces programmed cell death in tumor cells.

Methods: In this study, to evaluate the potential anti-cancer effects of chemotherapy combined …

An Overview Of The Relationships Between The Food Industry And Nanotechnology, Mehdi Koushki, Nasrin Amiri-Dashatan, Hossein Pourghadamyari, Hadi Khodabandehloo, Fatemeh Bagheri, Masoumeh Farahani, Lobat Tayebi

Electrical & Computer Engineering Faculty Publications

Background and Objective: Due to the growth of the global population, food demands are increasing. Hence, the need to develop more efficient methods for producing better quality, safer, and more sustainable food seems essential. In the past decades, the use of nanoscale materials has increased greatly due to the unique chemical, physical, and biological characteristics of nanomaterials compared to bulk materials. This research presents nanotechnology role in improving sensorial properties (taste, appearance, and texture) and safety aspects as well as processing and packaging of foods. The use of nano-omics-based technologies and artificial intelligence-nanotechnology-based technologies in the food industry is also …

Assessing De Novo Parasite Genomes Assembled Using Only Oxford Nanopore Technologies Minion Data, Kaylee Herzog, Rachel Wu, John M. Hawdon, Peter Nejsum, Joseph R. Fauver

Journal Articles: Epidemiology

In this study, we assessed the quality of de novo genome assemblies for three species of parasitic nematodes (Brugia malayi, Trichuris trichiura, and Ancylostoma caninum) generated using only Oxford Nanopore Technologies MinION data. Assemblies were compared to current reference genomes and against additional assemblies that were supplemented with short-read Illumina data through polishing or hybrid assembly approaches. For each species, assemblies generated using only MinION data had similar or superior measures of contiguity, completeness, and gene content. In terms of gene composition, depending on the species, between 88.9 and 97.6% of complete coding sequences predicted in MinION data only assemblies …

Neurocognitive Outcome In Children With Sickle Cell Disease After Myeloimmunoablative Conditioning And Haploidentical Hematopoietic Stem Cell Transplantation: A Non-Randomized Clinical Trial, Suzanne Braniecki, Shalini Shenoy, Robert C Mckinstry, Et Al.

2020-Current year OA Pubs

BACKGROUND: Due to the risk of cerebral vascular injury, children and adolescents with high-risk sickle cell disease (SCD) experience neurocognitive decline over time. Haploidentical stem cell transplantation (HISCT) from human leukocyte antigen-matched sibling donors may slow or stop progression of neurocognitive changes.

OBJECTIVES: The study is to determine if HISCT can ameliorate SCD-associated neurocognitive changes and prevent neurocognitive progression, determine which specific areas of neurocognitive functioning are particularly vulnerable to SCD, and determine if there are age-related differences in neurocognitive functioning over time.

METHODS: We performed neurocognitive and neuroimaging in SCD recipients following HISCT. Children and adolescents with high-risk SCD …

Claiming Our Place In The Center: Counterstories Of Women Of Color Open Educational Resources (Oer) Librarians, Regina Gong

Copley Library: Faculty Scholarship

Research has recognized the importance of libraries and librarians in supporting, managing, and sustaining open educational resources (OER) programs in postsecondary institutions. Open education initiatives generally align with social justice aspirations and should be open and inclusive to everyone. Yet, in practice, this has not always been the case. While librarians are considered critical partners in the leadership and management of OER programs and are often heralded as heroes and champions of these initiatives, research has failed to interrogate and discuss the experiences of Women of Color (WOC) doing OER work. In particular, the challenges and often invisible labor that …

Inactive Metallopeptidase Homologs: The Secret Lives Of Pseudopeptidases, Peter Lyons

Faculty Publications

Inactive enzyme homologs, or pseudoenzymes, are proteins, found within most enzyme families, that are incapable of performing catalysis. Rather than catalysis, they are involved in protein-protein interactions, sometimes regulating the activity of their active enzyme cousins, or scaffolding protein complexes. Pseudoenzymes found within metallopeptidase families likewise perform these functions. Pseudoenzymes within the M14 carboxypeptidase family interact with collagens within the extracellular space, while pseudopeptidase members of the M12 "a disintegrin and metalloprotease" (ADAM) family either discard their pseudopeptidase domains as unnecessary for their roles in sperm maturation or utilize surface loops to enable assembly of key complexes at neuronal synapses. …

What's In A Name? Standardization Of Vernacular Names For Trichechus Manatus, A. A. Mignucci-Giannoni, Daniel Gonzalez-Socoloske, Anmari Alvarez-Alemán, Jamie Aquino, D. Caicedo-Herrera, Delma Nataly Castelblanco-Martínez, Diane Claridge, M. Fabiola Corona-Figueroa, Adolphe O. Debrot, Benoit De Thoisy, Carlos Espinoza-Marin, J. Galves, Eddy Garcia-Alfonso, Hector M. Guzman, Jalaludin Ahmad Khan, Jeremy J. Kiszka, Fabia De Oliveira Luna, Miriam Marmontel, Leon David Olivera-Gomez, Christine O'Sullivan, James A. Powell, Enrique Pugibet-Bobea, Indranee Roopsind, Carlos J. Silva

Faculty Publications

Trichechus manatus is one of 3 recognized extant species of manatees of the mammalian Order Sirenia. Currently, it is known by various vernacular names, none of which are descriptive of its biology and known distribution. This lack of standardization has led to confusion and miscommunication, hindering conservation efforts for this species. We propose standardizing the vernacular names used to refer to the species and its 2 subspecies based on appropriate geographical characterization in English, Spanish, French, Dutch, and Portuguese, respectively: “American Manatee”, “Manatí de las Américas”, “Lamantin d’Amérique”, “Amerikaanse Lamantijn”, and “Peixe-boi das Américas” for T. manatus; “Florida Manatee”, “Manatí …

Scat Dna As A Non-Invasive Method For Estimating The Abundance Of The Vulnerable Mala (Lagorchestes Hirsutus), Shannon Treloar, Cheryl Lohr, Anna J. Hopkins, Kym Ottewell, Shelley Mcarthur, Robert A. Davis

Research outputs 2022 to 2026

Context: Population-monitoring programs often use direct (e.g. live capture or spotlighting) or indirect (e.g. scats sightings) observations to estimate population abundance. Such methods, however, are often inadequate for rare, elusive, or cryptic species due to the difficulty in achieving sufficient encounters or detection rates. The mala (Lagorchestes hirsutus), a small native Australian macropod, listed as Vulnerable by the IUCN, is difficult to capture, susceptible to capture myopathy, and not easily sighted in their dense habitat; consequently, the population size cannot always be estimated. The use of molecular markers to identify individual genotypes from non-invasively collected samples is increasingly being used …

Undergraduate Course Catalog Of The University Of San Diego 2024-2025, University Of San Diego

Undergraduate Course Catalogs (1973- )

614 pages. Includes information about academics, expenses, campus and the college, the 2024-2025 academic calendar, and school policies.

From Pollution To Resource: Advancing Swine Waste Treatment In The Usa, Viney P. Aneja, Ryke Longest, Matias B. Vanotti, Ariel A. Szogi, Gudigopuram B. Reddy

Faculty Scholarship

Concentrated animal feeding operations (CAFOs) have led to environmental challenges, specifically waste management. Swine CAFOs generate large amounts of waste, requiring proper treatment to avoid air and water pollution. Conventional waste management technologies, such as lagoon and spray field systems, do not prevent air and water pollution impacts. Research for the past few decades led to recommendations for waste treatment technologies superior to lagoons and spray fields. Private environmental sustainability initiatives focused on reducing greenhouse gas emissions in the food supply chain have implemented biogas digester projects for capturing methane in covered swine lagoons to reduce greenhouse gas emissions. However, …

A Codified Liability Regime To Stimulate Greater Investment In Subpatentable Innovation, Jerome H. Reichman, Ana Santos Rutschman

Faculty Scholarship

The global intellectual property system rests on a distinction between exclusive property rights and free competition. Exclusive rights vary in strength and intensity, but the opposite of protection is almost always free competition. Distinctions of intensity are drawn in terms of the length of protection given to different subject matters plus variable lists of exceptions and limitations to exclusive rights. But the bottom line is that, when protection is not available under the existing system, free competition prevails, and vice-versa (i.e., where there is exclusivity, free competition is deferred for a specified period of time).

This Article departs from a …

U.S. Public Perceptions Of The Sensitivity Of Brain Data, Shenyang Huang, Umika Paul, Shikhar Gupta, Karan Desai, Melinda Guo, Jennifer Jung, Beatrice Capestany, William D. Krenzer, Dylan Stonecipher, Nita A. Farahany

Faculty Scholarship

As we approach an era of potentially widespread consumer neurotechnology, scholars and organizations worldwide have started to raise concerns about the data privacy issues these devices will present. Notably absent in these discussions is empirical evidence about how the public perceives that same information. This article presents the results of a nationwide survey on public perceptions of brain data, to inform discussions of law and policy regarding brain data governance. The survey reveals that the public may perceive certain brain data as less sensitive than other ‘private’ information, like social security numbers, but more sensitive than some ‘public’ information, like …