Digital Commons Network^™

Development Of Novel Hydrogel Materials For Viscoelastically Accurate Brain Phantoms, Lila G. Schandler

Theses and Dissertations

Current methods such as concussion tests and Magnetic Resonance Imaging (MRI) scans only reveal structural damage post-injury. Creating an anatomically accurate model of the brain that mimics brain structure and viscoelastic properties will further allow medical professionals to analyze concussion events and create curated and personalized plans of recovery for a patient’s unique brain injury.

Values have been established for the necessary viscoelastic properties (time constants and elasticity) to mimic the native human brain tissue such as grey matter and white matter. The mechanical properties of the hydrogel are tunable by varying the concentration of Phytagel (PHY), a protein binding …

2024 Weed Science Research Report – Gold Section, Ndsu Weed Science, Dept. Of Plant Sciences

Plant Sciences Weed Science Reports

The Weed Science team at North Dakota State University conduct field research in the State of North Dakota. This specific document reports on field research conducted in 2024. It includes work on sugarbeet crops and the management of several weeds in North Dakota.

Hydrologic Pathways Of A Northern Hardwood Catchment In The Great Lakes Basin Using End Member Mixing Analysis, Cory C. Burkwald

Dissertations, Master's Theses and Master's Reports

This study investigated the seasonality of hydrologic pathways, the role of wetlands in streamflow generation, and how hydrologic pathways affect the export of nutrients by streamflow in the Sturgeon River using endmember mixing analysis. The results indicated that streamflow consists of three main components: shallow subsurface water from wetland soils, shallow groundwater, and surface runoff from precipitation. Snowmelt plays a dominating role in regulating stream water chemistry (~80% volume at peak) during the snowmelt season and likely also after that. Wetland soils store snowmelt, together with rainwater though the fraction is unknown, and then gradually release through summer in the …

Exploring The Molecular Pathways Of Cell Death Induced By Pde3 Modulators, Aqsa Ahsan

Dissertations, Master's Theses and Master's Reports

Metabolic dysregulation, a critical hallmark of cancer, predisposes potential vulnerabilities for the development of targeted therapy. LKB1, a pivotal metabolic regulator and tumor suppressor, is often lost in many cancers. Our laboratory has unveiled that LKB1 suppresses phosphodiesterases (PDEs), and PDE3 modulators can selectively eradicate LKB1-deficient tumor cells. Through metabolic gene sgRNA library screening, Sarcolipin, an inhibitor of Sarcoendoplasmic Reticulum Calcium ATPase (SERCA), emerged as essential for cell death in this context. However, the precise molecular mechanisms by which PDE3 modulators exert their effects remain elusive. This study aims to uncover these mechanisms via RNA-Seq profiling and differential gene analysis, …

Restoration Is Repairing Relationships: Bridging Indigenous And Western Sciences To Assess The Socio-Ecological Restoration Of Wild Rice (Zizania Palustris) On Keweenaw Bay Indian Community Homelands, Cassandra M. Reed-Vandam

Dissertations, Master's Theses and Master's Reports

Manoomin (wild rice, Zizania palustris) is an ecologically and culturally significant plant relative for the Keweenaw Bay Indian Community (KBIC). Historically, manoomin was present across much of the Great Lakes, however, their presence has declined since the early 1900s and, by 1990, virtually disappeared within KBIC homelands. Employing ethnography, surveys, focus groups, and conversations with Ojibwa knowledge holders, this research defined successful manoomin restoration for KBIC and developed socio-ecological attributes and indicators to assess restoration presented in the Medicine Wheel Framework for Manoomin Restoration. Surface water, sediment, and pore water samples at six different manoomin sites were analyzed to …

Gis-Based Landscape Prioritization To Guide Invasive Species Survey, Erin R. Mauk

Dissertations, Master's Theses and Master's Reports

Utilizing prioritization models gives invasive species managers the capability to systematically target surveying and management toward priority areas, therefore maximizing limited financial resources by increasing the value that management can have on the landscape. In this report, Geographic Information System (GIS) techniques were utilized to produce an invasion risk model and a quality land model. Combining these two models produced a landscape-level prioritization model, which denoted the land quality and associated invasion risk across the study area. High-quality land was commonly distributed within Isle Royale National Park, along Lake Superior’s coastline, and within coastal wetlands and riparian habitats. Areas of …

Anaerobic Reductive Bioleaching Of Manganese Ores, Neha Sharma

Dissertations, Master's Theses and Master's Reports

Manganese extraction by biological methods is a green and economical way to produce manganese from low as well as high grade manganese ores. This is especially important for US ores, which are primarily either small in extent, low-grade with a high iron content, or both. They are therefore not suitable for conventional mining, which is very capital-intensive and requires a large up-front investment and are therefore imported at high costs. The goal is therefore to develop a process that can be applied at small scales, with minimal startup costs, and low equipment and labor requirements. It is also critical to …

Novel Analytical Approaches For The Study Of Energy And Nutrient Flow In Streams, Michelle Catherine Kelly

Dissertations, Master's Theses and Master's Reports

This dissertation applied novel modeling, experimental and statistical approaches to overcome the challenges of measuring and analyzing energy and nutrient cycling in streams through 3 studies: (1) determining the predictors of respiration and denitrification in streams across the United States, (2) simultaneous estimation of denitrification and nitrogen (N) fixation rates, and (3) the impact of C lability metrics on the interpretation of C degradation in DOM incubation experiments. In the first study, I used predictive modeling approaches to show that respiration and denitrification were positively correlated across the landscape but were predicted by factors at different spatial scales. Denitrification rates …

Colombia´S National Mountain Peatland Map: Peatland Distribution, Condition And Carbon Stocks, Patrick Nicolas Skillings-Neira

Dissertations, Master's Theses and Master's Reports

In this research, I explore the distribution, condition, and carbon stocks of peatlands in the Colombian Andes. High mountain peatlands in Colombia, usually found within the páramos, face significant ecological challenges. Although Law 1930 (2018) mandates sustainable páramo management, it does not prohibit peatland disturbance. Undisturbed peatlands act as long-term carbon sinks, but their degradation can convert them into greenhouse gas sources. The lack of comprehensive national peatland mapping hampers effective environmental management and policy formulation. I aim to create a national-scale peatland map, assess peatland distribution, quantify degraded pasture peatlands, and report preliminary soil carbon stocks. Additionally, I compared …

Initial Solution Improvements To A Tethered Robotic Path Planner Using Random Geometric Graph Configurations And Biased Sampling, Austen J. Goddu

Dissertations, Master's Theses and Master's Reports

With NASA's ongoing efforts to establish a presence on the lunar surface to eventually move on to exploring mars, the development of intelligent robotic systems is more important than ever. The ability of robotics to explore hazardous and extreme terrain, coupled with long communication times from earth places an ever increasing need on more robust and efficient autonomy. Tethered robotics offer unique advantages to explore scientific targets both on the lunar and martian surfaces, capable of using their tether as a physical or metaphorical lifeline to allow the exploration of slopes, extreme dark regions, or areas in which wireless communication …

Concepts And Measures Of Human Intelligence And Anthropology: A Systematic Review Of Academic Literature From 1930s To 2010s, Leilani Maldonado

Honors Undergraduate Theses

This thesis explores the evolution of intelligence research and its contextualization within historical biases. Using a meta-analysis approach, the study examines word frequencies in academic literature spanning from the 1930s to the 2010s to identify shifting trends in intelligence discourse. Eleven search terms related to intelligence were analyzed to interpret changes in academic focus over time. The findings reveal significant shifts influenced by historical events, societal movements, and advancements in technology and methodology. From the prominence of IQ measures during World War II to the rise of cognitive science in the 1960s and the emergence of emotional intelligence in the …

Florida’S Most Recent Anti-Transgender Political Policies And Their Effects On Transgender Adults, Jaron A. Sanchez

Honors Undergraduate Theses

During May of 2023, Florida Governor Ron DeSantis signed multiple bills into law, which included House Bill 1521, Senate Bill 1580, and Senate Bill 254. Critics have regarded these bills to directly discriminate against transgender individuals and negatively impact their quality of life. The main research question this project seeks to answer is what impact these bills have, if any, on transgender individuals who live in the state of Florida. This includes experiences that negatively impact quality of life outcomes and mental health disparities. An online survey of a small sample of the population that self identifies as transgender, that …

Are You Looking At Me? The Relationship Between Social Media And Personality Disorders, Madison G. Goran

Honors Undergraduate Theses

This thesis investigates the relationship between social media and Cluster B Personality Disorders: Borderline Personality Disorder, Narcissistic Personality Disorder, Antisocial Personality Disorder, and Histrionic Personality Disorder. This research builds upon previous findings by examining specific negative social media motivations and behaviors, such as excessive use and negative motivations, in relation to Cluster B Personality Disorders. Participants completed the McLean Screening Instrument for Borderline Personality Disorder (MSI-BPD; Zanarini et al., 2005), The Short Dark Triad (Jones &Paulhus, 2014), Antisocial Process Screening Device (Frick & Hare, 2002), Self-Test Histrionic Personality Disorder (Olivardia, 2022), and Motivations for Social Media Use Scale (MSMU; Rodgers …

Effectiveness Of Doxycycline As Post-Exposure Prophylaxis (Doxy-Pep) For Bacterial Sexually Transmitted Infections (Stis) Among Men Who Have Sex With Men (Msm) In Central Florida, Micah P. Greer

Honors Undergraduate Theses

Bacterial sexually transmitted infections (STIs), notably syphilis, gonorrhea, and chlamydia, have been increasing among men who have sex with men (MSM) in the United States. The rise has been attributed to various factors, including increased condomless sexual acts due to the high uptake of pre-exposure prophylaxis (PrEP) for HIV prevention. To address this concerning trend, post-exposure prophylaxis with doxycycline (Doxy-PEP) has emerged as a potential biomedical intervention. This study aimed to assess the effectiveness of Doxy-PEP in preventing bacterial STIs among MSM in Central Florida, a region with rising STI rates. A de-identified dataset from Pineapple Health Clinic in Orlando, …

Antagomir Treatment For Deep-Space Simulated Changes In The Liver Of Mice, Natalie P. Hayslip

Honors Undergraduate Theses

With the start of NASA’s Artemis program, astronauts will soon leave the protection of Earth’s magnetosphere. Previous studies have established a theme of liver dysregulation associated with the harmful radiation and microgravity experienced in deep space. MicroRNAs (miRNAs) are key regulators of many of the pathologies observed during and after spaceflight, including hepatic fibrosis, making them strong potential biomarkers and therapeutic targets. Therefore, in the present study we investigated the effects of simulated microgravity, galactic cosmic radiation (GCR), and solar particle events (SPE) on miRNAs and mRNAs involved in the TGF-β signaling pathway, a key regulator of fibrosis, senescence, and …

The Effects Of Resistance Training On Older Adults: Increasing Healthspan And Lowering Disability Rates, Michael M. Samuel

Honors Undergraduate Theses

This study analyzed the research on older adults and resistance training exercise and assessed effects on health span and lowering disability rates. A targeted search of the literature was employed using the following key words: sarcopenia, resistance training, hypertrophy, quality of life, disability, activities of daily living, strength training, falls, and functional strength. These were used to find articles that were relevant to the research. Articles were excluded if they focused on young athletes as they did not meet my research age group. Articles that focused on nutrition were also excluded as they pulled the focus away from the impact …

Determining The Differences Of Racial Microaggressions Faced By Multiracial Versus Monoracial Minority Patients Within Healthcare Settings, Elizabeth S. Ommi

Honors Undergraduate Theses

This study examines the disadvantages that multiracial patients face when seeking healthcare in the United States in comparison to the disadvantages encountered by monoracial minority patients. Specifically, this study mainly focuses on the impacts of racial microaggressions within such medical settings. This was explored using a critical discourse analysis, analyzing discourse presented from past research published from 2014 to 2023. Discourse was collected based on its relevancy to the given topic and was analyzed to identify general disadvantages presented for each subpopulation. It was found that multiracial patients face different disadvantages when receiving medical care in comparison to monoracial minority …

Fertility Preservation: A Critical Review Of Information Available To Testicular Cancer Patients, Markram Groenewald

Honors Undergraduate Theses

Fertility preservation remains a crucial component of Testicular Cancer patients’ health-related quality of life. Significant inconsistency is present in the availability and accessibility of information related to fertility preservation for patients with Testicular Cancer. The purpose of this critical review was to determine the quantity and quality of fertility preservation provided through the websites of top cancer care centers. A total of 15 centers were chosen based on the top cancer centers from US News and World Report and expanded upon using Definitive Healthcare’s top 10 centers treating Testicular Cancer by volume. Webpages were collected and graded for accessibility of …

Monitoring Faunal Responses To Biodegradable Oyster Reef Restoration Materials With Camera Traps, Tara L. Blanchard

Honors Undergraduate Theses

Restoration of the oyster reefs has become increasingly crucial due to great population declines around the globe. Intertidal oyster reefs provide essential foraging and loafing grounds to many faunal species, including several threatened/endangered wading bird species. Biodegradable oyster reef restoration materials have been introduced to avoid potential plastic pollution from traditional materials. Studies have shown success regarding oyster recruitment rates to these materials. However, their impacts on fauna using restored oyster reefs are unknown. This project aims to evaluate oyster reef restoration using biodegradable materials to increase faunal diversity, abundance, and foraging behaviors. Camera traps were deployed to observe fauna …

Examining The Effects Of Artemisia Annua On Neuro2a Cells, Wesley Lim

Honors Undergraduate Theses

Artemisia annua L. is a well-known medicinal herb used in Traditional Chinese Medicine for many centuries and contains artemisinin, which exhibits antimalarial properties [1] and is a potential treatment for SARS-CoV-2 [2]. However, the neurological effect of A. annua and its compounds are poorly understood. We hypothesize that A. annua extracts and artemisinin will provide protection against oxidative stress in mouse neuronal Neuro2A cells. Superoxide dismutase 1 (SOD1) is an anti-oxidant enzyme that protects against oxidative damage [3]. Growth Arrest and DNA Damage-inducible 45 alpha (Gadd45a) is involved in DNA repair and is a common biomarker for DNA damage[4]. SOD1 …

Curanderismo And Healing: Insights From Hispanic Young Adults, Allisa Castro

Honors Undergraduate Theses

Curanderismo is a holistic form of traditional medicine primarily used by Latin American populations and Hispanic communities in the United States. This type of care focuses on several aspects of health including physical, emotional and spiritual (supernatural). Hispanics are the largest ethnic minority population in the United States and yet healthcare access to this population remains limited by various barriers including lack of insurance, legal status, language, poverty, and other structural factors. Within this context, exploring the perceptions and role of traditional medicine, like curanderismo, as a form of healthcare becomes crucial in understanding and addressing the unique healthcare needs …

Examining Wrack In Mosquito Lagoon To Analyze Biodiversity And Seagrass Viability, Nicole Jerrell

Honors Undergraduate Theses

Seagrass restoration of Halodule wrightii, has become crucial as seagrass coverage in the Indian River Lagoon (IRL) declined by 58% between 2011 and 2019. To understand the abundance of seagrass fragments available for natural recruitment and restoration, we tracked the abundance of viable fragments found in the wrack in Mosquito Lagoon. Wrack is plant material, including seagrass fragments, mangrove propagules, and detritus. Seagrass fragments were considered viable if the fragment had an apical meristem present. Replicate samples were collected from 5 locations every two weeks, starting in September 2022 and ending in September 2023, and the samples were processed …

Tracking The Reaction Networks Of Criegee Intermediates Formed In The Ozone-Assisted Oxidation Reactions Of C5 Acyclic And Endocyclic Alkenes, Arden M. Floyd

Honors Undergraduate Theses

Uni- and bi-molecular reactions involving Criegee intermediates (CIs), characteristic to alkene-ozone reactions, play an important role in synthetic organic, atmospheric, and combustion chemistry. However, difficulty in detecting key intermediates has prevented a thorough understanding of the details of the ozonolysis mechanism. To gain new insights into how alkene structure affects the CI network, the ozone assisted oxidation reactions of trans-2-pentene and cyclopentene are investigated between 320 K and 760 K in an atmospheric pressure jet stirred reactor (JSR). Molecular-beam mass spectrometry in conjunction with single photon tunable synchrotron VUV radiation is used to identify elusive intermediates by means of …

Exploring The Link Between Neurocognitive Function And Long Covid: A Comprehensive Review, Dinamaris Aguilar

Honors Undergraduate Theses

The intent of this thesis is to provide an in-depth overview of the neurological manifestations associated with long COVID. The review aimed to assess the cognitive functioning symptoms associated with SARS-CoV-2 post-infection (PASC), investigate the potential mechanisms by which SARS-CoV-2 affects the nervous system, contributing to cognitive fatigue, brain fog, and cognitive dysfunction, and explore the parallels between SARS-CoV-2 and Alzheimer’s Disease. Neuroinflammation emerges as a shared element among these mechanisms, significantly impacting cognitive function. The parallels between COVID-19 and Alzheimer's Disease offer insights into how Alzheimer's affects cognition, aiding in understanding COVID-19's impact. The review underscores a notable gender …

The Effects Of Nanobubbles For Gene Delivery For Osteoporosis Treatment, Abel Córdova Flores

Honors Undergraduate Theses

In recent years, the field of nanomedicine has provided promising alternatives to traditional ways of gene and drug delivery, such as nanobubbles instead of viral vectors. Manufacturing these nanomaterials is cost-effective and tends to be safer than previous forms of treatment for clinical use. In the realm of osteoporosis, a disease based around a higher rate of bone resorption to bone formation, leads to weak and brittle bones, leaving sufferers at risk for fractures, which are sudden and unexpected. These fractures are estimated to cost USD 22 Billion annually in the US alone. Reports show a significant effect on the …

Adaptation Of A Commercially Available Galvanic Skin Response Sensor To Measure Respiration Across The Chest For Heart Rate Variability Monitoring, Breno C. Dobal

Honors Undergraduate Theses

Heart rate variability (HRV) is a naturally occurring cardiovascular phenomenon referring to the changing timing between consecutive heartbeats. The connection between HRV and overall cardiovascular health and autonomic nervous system function has been well established through prior research and well documented in existing literature. The existing studies, however, included shorter HRV subject recording session, using traditional HRV monitoring methods that do not typically combine electrocardiogram (ECG), seismocardiogram (SCG) and galvanic skin response (GSR) respiration monitoring. The inclusion of longer HRV subject recording may allow for further insight on the possible effects of given observable biological phenomenon on HRV.

The current …

Masculinity And Political Discourse: A Critical Analysis Of European Leaders, Taylor R. Haycock

Honors Undergraduate Theses

This project examines how European leaders of autocratic and democratic nations engage with masculinity discourses in their public speeches. Do authoritarian leaders use masculinity in a different way than democratic leaders? I answer this question by completing a critical discourse analysis of speeches from Vladimir Putin, Recep Tayyip Erdoğan, Boris Johnson, and Emmanuel Macron, the leaders of Russia, Turkey, the United Kingdom, and France, respectively. The speeches were publicized from July 2019 to September 2022, when all four leaders were simultaneously in office. I found that a similar rhetorical strategy focusing on dominance and strength was used across regime types …

An Investigation Of Students' Modes Of Thinking Concerning Linearity In Linear Algebra, Noa Levy

Honors Undergraduate Theses

The intent of this thesis is to investigate student approaches to linearity within a linear algebra context, focusing on definitional, computational, and theoretical skills. Linear algebra’s abstract nature constitutes a major challenge for a significant sector of STEM students, with the course often serving as undergraduates’ first encounter with mathematical proofs and extrapolations. The current student struggle is reflected through the prominent gap in knowledge derived from a lack of a concrete understanding of rudimentary concepts (like linearity), pivotal to student success. As such, this investigation aimed to bridge this gap by considering students’ modes of thinking regarding the elementary …

Healthcare Disparities Among Hypermobile Spectrum Disorder And Hypermobile Ehlers-Danlos Syndrome Patients, Brooke A. Martinez

Honors Undergraduate Theses

Hypermobile Ehlers-Danlos Syndrome (hEDS) is the most common subtype of rare connective tissue disorder called Ehlers-Danlos Syndrome (EDS). Hypermobile Spectrum Disorder (HSD) is a connective tissue disorder that presents itself similarly to hEDS. Both disorders primarily affect individuals assigned to females at birth (AFAB), and symptoms range from joint instability, musculoskeletal pain, dizziness, fatigue, depression, and anxiety. Due to many factors like lack of education or attitudes among medical professionals (MPs), receiving a diagnosis of either of these conditions can be a challenging and grueling journey for patients. An online survey was conducted and distributed over social media platforms to …

Reliable Detection Of Wnt7a Protein In Transfected Human Embryonic Kidney 293 Cells, Henry Okonkwo

Honors Undergraduate Theses

Fetal Alcohol Spectrum Disorders (FASDs) refer to a set of development abnormalities affecting a fetus that can result from prenatal alcohol exposure (PAE). Studies performed by the National Institute of Health estimate that the pervasiveness of FASDs may number as high as 1 to 5 per 100 school children. Congenital heart defects (CHDs) are a subset of these abnormalities and have been observed to occur in 38% of children with FASDs. While there is an association between PAE and CHDs, the exact molecular mechanism as to how it occurs remains unclear. A 2022 RNA sequencing study points to the Wnt7a …