Digital Commons Network^™

Notes On Patagium Morphology In The Gliding Flat-Tailed House Gecko (Hemidactylus Platyurus), Amber M. Petty, Tony Gamble, Aaron H. Griffing

Biological Sciences Faculty Research and Publications

Several species of geckos have independently evolved patagia, membranous features that facilitate gliding. Detailed morphological investigations of gecko patagia have largely been limited to gliding members of the genus Gekko (formerly in the genus Ptychozoon). Herein we describe the morphology of gliding patagia of the Flat-tailed House Gecko (Hemidactylus platyurus), a species with an independent evolutionary origin of gliding patagia from Gekko and an important species for researching gliding biomechanics. We compared morphology of H. platyurus with a closely related non-gliding species, the Common House Gecko (Hemidactylus frenatus). Using external examination and histological techniques, we …

Ai Is A Viable Alternative To High Throughput Screening: A 318-Target Study, Martin St. Maurice

Biological Sciences Faculty Research and Publications

High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, …

Bacillus Subtilis-Derived Peptides Disrupt Quorum Sensing And Biofilm Assembly In Multidrug-Resistant Staphylococcus Aureus, Kyle R. Leistikow, Daniel S. May, Won Se Suh, Gabriel Vargas Asensio, Adam J. Schaenzer, Cameron R. Currie, Krassimira R. Hristova

Biological Sciences Faculty Research and Publications

Multidrug-resistant Staphylococcus aureus is one of the most clinically important pathogens in the world, with infections leading to high rates of morbidity and mortality in both humans and animals. The ability of S. aureus to form biofilms protects cells from antibiotics and promotes the transfer of antibiotic resistance genes; therefore, new strategies aimed at inhibiting biofilm growth are urgently needed. Probiotic species, including Bacillus subtilis, are gaining interest as potential therapies against S. aureus for their ability to reduce S. aureus colonization and virulence. Here, we search for strains and microbially derived compounds with strong antibiofilm activity against multidrug-resistant S. …

Not Just Bony Fish: All Nonmammalian And Nonavian Animals Are Neglected In Both Welfare And General Research, Jennifer A. Mather Ph.D.

Animal Sentience

The lack of research on fish welfare highlighted by Oldfield & Bonano (2024) is only part of a more general problem: a relative neglect of animals other than mammals and birds. The causes are our lack of knowledge, our negative view of what we consider to be “lower” animals and our underestimation of their intelligence and sensitivity. Our estimation will increase as our knowledge increases. As a broader view spreads to the public through the media, it should gradually increase the demand to expand both research and welfare, especially beyond mammals and birds.

Acting In Self-Defense: The Creation Of An Online Systematic Review Tutorial To Assist Librarian Consultations, Sally Smith, Karen Burton, Shelby Carroll

Publications

Clemson University Libraries provides expert research services and has experienced a growing number of requests for guidance regarding evidence synthesis projects. In response, a team of three early-career science librarians sought to create a comprehensive online tutorial on the systematic review process. The tutorial outsources introductory education and features learning objects and assessments for each step. The tutorial streamlines consultations, freeing librarians to focus on project specifics. Accompanying participation guidelines clarify roles and responsibilities, timely completion of reviews, and authorship expectations. This asynchronous tutorial supports an equitable service model, benefiting researchers across all fields.

Basic Principles Of Chronic Wound Care Management, Mahi-Ruhi Ladhani Jain

Capstone Showcase

This CME article aims to address the basics of chronic wound management, especially related to chronic venous insufficiency, peripheral arterial disease, and diabetes. Many providers do not know how to treat or manage chronic wounds and may use outdated methods to treat the wounds. There are many wound care supplies and resources available for providers when it comes to wound care management. However, the information is spread out across different resources. This article aims to create a resource that allows one to have a basic understanding of wounds and the different ways to manage them. In the article, I will …

Reintegration Of Street-Connected Children In Kenya: Evaluation Of Agape Children's Ministry's Family Strengthening Programme, Johanna K. P. Greeson, John Gyourko, Sarah Wasch, Christopher Page

Department of Social Work - Faculty Scholarship

In Kenya, the number of street-involved children continues to grow each decade, with most recent estimates as high as 250,000 to 300,000. Despite efforts by local government, nongovernmental organizations, and community-based organizations to address this problem, most children who receive services end up returning to the streets. Since 2021, Agape Children's Ministry has provided time-limited, crisis-oriented services to families recently reintegrated through its Family Strengthening Programme (FSP). We conducted an exploratory programme evaluation of Agape's FSP to ascertain whether it is achieving the intended outcomes. Thirty families (n = 30 children; n = 38 caregivers) were enrolled in the …

Research On The Lived Experiences Of Adolescents And Adults With Foster Care History: A Scoping Review, John Gyourko, Johanna K. P. Greeson, Nick Vasquez, Linda-Jeanne M. Mack, Ahmir Kenyatta, Richard P. Barth, Antonio Garcia

Department of Social Work - Faculty Scholarship

Objective: Many child welfare scholars, practitioners, and funders are calling for greater inclusion of “lived experience” data and stakeholder voices in foster care research. Yet to date there have been no comprehensive summaries of studies that analyze data collected directly from older youth and adults with lived experience in out-of-home care. To address this knowledge gap, this scoping review maps the extent, nature, and sample characteristics of studies that analyzed data provided by persons age 14 and older with lived foster care experience. Method: We conducted a systematic search of 11 scholarly databases to locate studies (published from1999–2021) …

Predictors Of Identity Crime Victimization Of Adolescent Youth In Foster Care, John Gyourko, Greg Ridgeway

Department of Social Work - Faculty Scholarship

Identity crimes pose serious risks and challenges for youth in foster care. As young people move through various out-of-home placements and schools, their personal data are often widely disseminated, difficult to secure, and thus vulnerable to theft and misuse. When they transition from foster care to adulthood, identity crime victims with compromised credit histories may be denied loans, employment, and/or housing during the already-precarious period of emerging adulthood. Even though federal law requires state child welfare agencies to conduct annual credit checks for adolescent youth in foster care, little is known about the factors contributing to risk of identity crime …

Development Of A Diaryl Oxazole-Based Cleavable Linker For Peptides, Evan Wolff

Honors Theses

The development of new cleavable linkers increases the diversity of compatible conditions for peptide discovery platforms. Potential applications for these linkers include high-throughput pharmaceutical candidate screening when utilized in Peptide Encoded Libraries (PELs). This thesis describes the development of a bifunctional diaryl oxazole-based cleavable linker that may be incorporated into compounds through Solid-Phase Peptide Synthesis (SPPS). This oxazole-based linker may be rapidly cleaved by cerium ammonium nitrate in aqueous conditions and is compatible with most natural amino acids and a variety of unnatural amino acids. This linker represents the first single-electron oxidant labile linker described to our knowledge and it …

Opioid Policy Solutions: Administrative Law, Legislation, And Constitutional Reform, Trevin Stevens

Honors Theses

I have written three separate policy briefs addressing issues in the pharmaceutical industry that allowed for the opioid epidemic to reach the magnitude that it has in the last three decades. I examined public policy regarding labeling, drug diversion, and misuse, as well as marketing. By studying existing policies, I was able to provide insight into possible reforms, while accounting for potential obstacles to systematic reform, such as constitutional concerns regarding free speech.

Native Nations' Autonomy In The Modern Era, Brynna Collins

Public Interest Law Reporter

No abstract provided.

The Epa's Failure To Revise The Clean Water Act And Its Impact On Communities, Will Matushek

Public Interest Law Reporter

No abstract provided.

Effectiveness Of Cleanup And Dredging Operations On Some Heavy Metal Residues In Fish Flesh From Manzala Lake, Egypt, Heba Rahmo, Samir Abd-Elghany, Amira Ibrahim Zakaria

Mansoura Veterinary Medical Journal

OBJECTIVES: The current study aimed to evaluate the effectiveness of cleanup and dredging operations in Manzala Lake on the levels of mercury, arsenic, lead, and cadmium in fish muscles and compare them with the concentrations previously recorded in the same lake before treatment. METHODS: A total of 180 fish samples, including 60 each of Nile tilapia (Oreochromis niloticus), flathead grey mullet (Mugil cephalus), and African catfish (Clarias gariepinus), were analyzed using atomic absorption spectrophotometry. RESULTS: The mean concentrations (mg/kg) of Hg, As, Pb, and Cd in tilapia were 0.01 ± 0.03, 3.16 ± 0.35, 1.01 ± 0.16, and 0.12 ± …

The Targeted Application Of Colour Doppler Ultrasonography In Dairy Cows Management, Mohammed A Elmetwally, Heinrich Bollwein, Amira M Mostagir, Alaa Samy, Fatma Adlan, Sara Shalapy, Amal Helmy, Yasser Y. Lenis, Mariam M Rabie, Mohamed Gohar, Walid Tawfik, Heba A Sharawy

Mansoura Veterinary Medical Journal

The management of reproduction in dairy herds has profited tremendously from technical improvements, greater usage of ovulation synchronization procedures, and fixed-time automated monitoring devices. The purpose of this review article is to highlight the importance of noninvasive color Doppler ultrasound imaging based on the target reproductive management of dairy cows. Noninvasive measurement of uterine and vaginal blood flow in dairy cows is variable during the estrous cycle, pregnancy, and puerperium. Transrectal uterine and vaginal arterial blood flow changes can be utilized to determine changes in female genital functions during the estrous cycle, pregnancy, and puerperium, according to the findings of …

Protective Effect Of Cichorium Intybus ( Dandelion) Against Thiamethoxam Induced Hepatotoxicity In Chicken, Aml M. Mohammed, Magdy S. Amer, Aza E. Hassan, Ahmed Ateya, Eman S. El-Ashry

Mansoura Veterinary Medical Journal

Background : Thiamethoxam (TMX) is a dangerous neonicotinoid pesticide that induces liver damage in chickens. In this study, the toxicity of TMX in chicken was examined along with the capacity of dandelion extract to alleviate TMX toxicity. Methods: A total of 48 one-day-old, clinically healthy, non-vaccinated chicks. Chicks were divided into four groups (12 chicks per group): control (saline), TMX, TMX + Dandelion (DAN), and DAN + TMX. The treatment groups were orally administered TMX at 500 mg/kg BW and dandelion extract at 400 mg/kg BW, and the experiment was extended over 60 days. Blood samples were collected at 60th …

Washington University Magazine, April 2024

Washington University Magazine

No abstract provided.

Limiting Tourism To Sustainable Levels: Options For HawaiʻI, Barry D. Solomon

Natural Resources Journal

Many popular tourist destinations across the world are experiencing overtourism, which can cause a variety of negative environmental and socio-cultural impacts. As a result, an increasing number of governments are searching for solutions to overtourism. In the United States, Hawaiʻi needs such solutions. Until recently, many legal scholars and other observers believed that restricting tourism may be unconstitutional. However, a careful examination of the United States Supreme Court’s decisions on the Dormant Commerce Clause and the interstate right to travel show that certain restrictions on tourism may be constitutionally permissible. Indeed, recent federal court rulings support state action designed to …

Childhood Feeding And Eating Evaluation And Home Programming, Alexis Paige Lehmann

Occupational Therapy Capstones

Background: Up to 20% of typically developing and about 80% of atypically developing infants and children suffer from feeding difficulties (Chatoor & Macaoay, 2008; Nichols et al., 2018). These feeding difficulties may lead to delays in growth and development, refusal to eat, behavioral issues, and medical complications (Chatoor & Macaoay, 2008). Occupational therapists address these feeding difficulties through the therapeutic process, which includes initial evaluation, intervention, re-evaluation, and discharge planning (American Occupational Therapy Association [AOTA], 2020). When completing a feeding evaluation, practitioners often rely on skilled observation and their clinical judgment to determine what is developmentally appropriate. Practitioners also may …

Why I Will Not Stop Teaching Law Students To Think Critically About Race: The Attack On Teaching About The Role Of Race In Law, Leroy Pernell

Journal Publications

As someone who has been involved in legal education teaching for over 40 years and as someone who was drawn to legal education as an alternative to a career more directly devoted to litigation concerning racial justice, so that others might be encouraged to explore critically both what race has meant to our legal system and how we might collectively counter its negative influence, the “Stop W.O.K.E act” presents a real and present danger. Thus, in August of 2022 I agreed to be the lead named plaintiff in Pernell, et. al. v. Florida Board of Governors of the State University …

Disorganization Of Actin Within The Shafts Of Stereocilia Is A Key Difference Between Temporary And Permanent Noise-Induced Hearing Loss (Nihl), Shadan Hadi

Theses and Dissertations--Physiology

During sound stimulation, mechanosensory stereocilia of the auditory hair cell pivot around their bases, where their actin cores become denser and form rootlets protruding into the cuticular plate. It is believed that actin-based cuticular plate provides a stable mechanical support for stereocilia, while rootles are responsible for their pivotal flexibility and life-long resilience to mechanical stimuli. Not surprisingly, damage to the stereocilia bundles is known as a hallmark of permanent noise-induced hearing loss (NIHL). Yet, despite decades of NIHL studies, it is still unknown which ultrastructural changes in the stereocilia bundles are evoked directly by mechanical overstimulation.

Here, we explored …