Digital Commons Network^™

Underlying Substrate Effect On Electrochemical Activity For Hydrogen Evolution Reaction With Low-Platinum-Loaded Catalysts, Baleeswaraiah Muchharla, Peter V. Sushko, Kishor K. Sadasivuni, Wei Cao, Akash Tomar, Hani Elsayed-Ali, Adetayo Adedeji, Abdennaceur Karoui, Joshua M. Spurgeon, Bijandra Kumar

Electrical & Computer Engineering Faculty Publications

Platinum is known as the best catalyst for the hydrogen evolution reaction (HER) but the scarcity and high cost of Pt limit its widespread applicability. Herein, the role of the underlying substrate on the HER activity of dispersed Pt atoms is uncovered. A direct current magnetron sputtering technique is utilized to deposit transition metal (TM) thin films of W, Ti, and Ta as underlying substrates for extremely low loading of Pt (

Recent Progress In Microrna Detection Using Integrated Electric Fields And Optical Detection Methods, Logeeshan Velmanickam, Dharmakeerthi Nawarathna

Electrical & Computer Engineering Faculty Publications

Low-cost, highly-sensitivity, and minimally invasive tests for the detection and monitoring of life-threatening diseases and disorders can reduce the worldwide disease burden. Despite a number of interdisciplinary research efforts, there are still challenges remaining to be addressed, so clinically significant amounts of relevant biomarkers in body fluids can be detected with low assay cost, high sensitivity, and speed at point-of-care settings. Although the conventional proteomic technologies have shown promise, their ability to detect all levels of disease progression from early to advanced stages is limited to a limited number of diseases. One potential avenue for early diagnosis is microRNA (miRNA). …

Different Visions From Biosview: A Brief Report, Lucas N. Potter, Xavier-Lewis Palmer

Electrical & Computer Engineering Faculty Publications

In this collaborative research endeavor at the intersection of biological safety and cybersecurity for BiosView labs, the authors highlight their engagement with a diverse student cohort. The chapter delves into the motivation behind collaborations extending beyond traditional academic research environments, emphasizing inclusivity. The meticulous examination of student demographics, including gender, self-reported ethnicity, and national origin, is detailed in the methodology. A student-centric approach is central to the exploration, focusing on aligning teaching and management styles with unique student needs. The chapter elaborates on effective teaching methodologies and management practices tailored for BiosView labs. A dedicated section emphasizes the purpose of …

Paper-Based Dna Biosensor For Rapid And Selective Detection Of Mir-21, Alexander Hunt, Sri Ramulu Torati, Gymama Slaughter

Electrical & Computer Engineering Faculty Publications

Cancer is the second leading cause of death globally, with 9.7 million fatalities in 2022. While routine screenings are vital for early detection, healthcare disparities persist, highlighting the need for equitable solutions. Recent advancements in cancer biomarker identification, particularly microRNAs (miRs), have improved early detection. MiR-21 is notably overexpressed in various cancers and can be a valuable diagnostic tool. Traditional detection methods, though accurate, are costly and complex, limiting their use in resource-limited settings. Paper-based electrochemical biosensors offer a promising alternative, providing cost-effective, sensitive, and rapid diagnostics suitable for point-of-care use. This study introduces an innovative electrochemical paper-based biosensor that …

Investigation Of The Effect Of Preparation Parameters On The Structural And Mechanical Properties Of Gelatin/Elastin/Sodium Hyaluronate Scaffolds Fabricated By The Combined Foaming And Freeze-Drying Techniques, Mansour Qamash, S. Misagh Imani, Meisam Omidi, Ciara Glancy, Lobat Tayebi

Electrical & Computer Engineering Faculty Publications

This paper aimed to evaluate the effects of different preparation parameters, including agitation speed, agitation time, and chilling temperature, on the structural and mechanical properties of a novel gelatin/elastin/sodium hyaluronate tissue engineering scaffold, recently developed by our research group. Fabricated using a combination of foaming and freeze-drying techniques, the scaffolds were assessed to understand how these parameters influence their morphology, internal microstructure, porosity, mechanical properties, and degradation behavior. The fabrication process used in this study involved preparing a homogeneous aqueous solution containing 8% gelatin, 2% elastin, and 0.5% sodium hyaluronate (w/v), which was then subjected to mechanical agitation at speeds …

A Review Of Emerging Sensor Technologies For Tank Inspection: A Focus On Lidar And Hyperspectral Imaging And Their Automation And Deployment, Sergio Pallas Enguita, Chung-Hao Chen, Samuel Kovacic

Electrical & Computer Engineering Faculty Publications

This paper reviews various sensor technologies for tank inspection, focusing on Light Detection and Ranging (LiDAR) and Hyperspectral Imaging (HSI) as advanced solutions for corrosion detection. These technologies are evaluated alongside traditional methods such as ultrasonic, electromagnetic, and thermographic inspections. This review highlights their potential to enhance inspection accuracy, reduce the limitations of manual inspection, and support integrated data analysis for comprehensive asset management. Additionally, this paper proposes a pathway for automating these techniques to streamline inspection processes and improve implementation in practical applications.

Methylene Blue-Mediated Photodynamic Therapy In Combination With Doxorubicin: A Novel Approach In The Treatment Of Ht-29 Colon Cancer Cells, Nima Rastegar-Pouyani, Jaber Zafari, Alireza Nasirpour, Hossein Vazini, Nabbaa Najjar, Seyedeh Zohreh Azarshin, Fatemeh Javani Jouni

Electrical & Computer Engineering Faculty Publications

Introduction: With an alarmingly growing number of patients diagnosed with colorectal cancer, adopting innovative anti-cancer approaches has recently garnered great attention. One interesting concept is the co-administration of cytotoxic agents and safer modalities such as photodynamic therapy (PDT), which can subsequently improve therapeutic efficacy and potentially reduce the risks of severe adverse effects and drug resistance. In the course of PDT, a locally injected photosensitizer (PS) is irradiated with a light source, which subsequently generates reactive oxygen species (ROS) and induces programmed cell death in tumor cells.

Methods: In this study, to evaluate the potential anti-cancer effects of chemotherapy combined …

An Overview Of The Relationships Between The Food Industry And Nanotechnology, Mehdi Koushki, Nasrin Amiri-Dashatan, Hossein Pourghadamyari, Hadi Khodabandehloo, Fatemeh Bagheri, Masoumeh Farahani, Lobat Tayebi

Electrical & Computer Engineering Faculty Publications

Background and Objective: Due to the growth of the global population, food demands are increasing. Hence, the need to develop more efficient methods for producing better quality, safer, and more sustainable food seems essential. In the past decades, the use of nanoscale materials has increased greatly due to the unique chemical, physical, and biological characteristics of nanomaterials compared to bulk materials. This research presents nanotechnology role in improving sensorial properties (taste, appearance, and texture) and safety aspects as well as processing and packaging of foods. The use of nano-omics-based technologies and artificial intelligence-nanotechnology-based technologies in the food industry is also …

Unexpected Ring Opening Reactions, Solid-State Structures, And A Chemiluminescent Reaction, L Hiscock

Theses and Dissertations (Comprehensive)

Functional π-materials involve the use of an aromatic π-system to carry out a function such as electron transport (organic electronics), absorbing and emitting photons (dyes, fluorescent materials), self-assembly (discotic liquid crystals), or sensors for various analytes. Our lab has recently published the syntheses of heteroaromatic derivatives of tetrafluoroterephthalonitrile (TFTP, 2.24) synthesised via nucleophilic aromatic substitution chemistry. The prepared derivatives have displayed fluorescent (e.g. 2.2)1 and liquid crystalline (1.0)2 properties, as well as displaying close π-π interactions in the solid state (2.8).3 As the materials we are synthesising all belong to the class of aromatic compounds, an introduction to aromaticity and …

Coordination Chemistry Using Strategic Design Of Ligands For Switchable Properties, Delara Joekar

Theses and Dissertations (Comprehensive)

Coordination-driven self-assemblies are multifunctional molecular systems that provide an efficient method for miniaturization towards functional devices with diverse applications. Herein, the synthesis of novel pyrazole-based ligands suitable for construction of coordination assemblies is reported. These were designed using a strategy that incorporates the presence of both cationic and anionic coordination sites, and a third site for further functionalization. This design strategy has been used because there is still a knowledge gap for controlling the directionality of weak molecular forces in the presence of stronger competing forces. The structural characterization of these ligands, their Hirshfeld surface analysis, and select coordination complexes …

Pcv15, A Pneumococcal Conjugate Vaccine, For The Prevention Of Invasive Pneumococcal Disease In Infants And Children., Timothy J. Chapman, Liset Olarte, Ghassan Dbaibo, Avril Melissa Houston, Gretchen Tamms, Robert Lupinacci, Kristen Feemster, Ulrike K. Buchwald, Natalie Banniettis

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION:

Streptococcus pneumoniae is a causative agent of pneumonia and acute otitis media (AOM), as well as invasive diseases such as meningitis and bacteremia. PCV15 (V114) is a new 15-valent pneumococcal conjugate vaccine (PCV) approved for use in individuals ≥6 weeks of age for the prevention of pneumonia, AOM, and invasive pneumococcal disease.

AREAS COVERED: This review summarizes the V114 Phase 3 development program leading to approval in infants and children, including pivotal studies, interchangeability and catch-up vaccination studies, and studies in at-risk populations. An integrated safety summary is presented in addition to immunogenicity and concomitant use of V114 with …

Statistical Analysis Of Single-Cell Protein Data., Brooke L. Fridley, Simon Vandekar, Inna Chervoneva, Julia Wrobel, Siyuan Ma

Manuscripts, Articles, Book Chapters and Other Papers

Immune modulation is considered a hallmark of cancer initiation and progression, with immune cell density being consistently associated with clinical outcomes of individuals with cancer. Multiplex immunofluorescence (mIF) microscopy combined with automated image analysis is a novel and increasingly used technique that allows for the assessment and visualization of the tumor microenvironment (TME). Recently, application of this new technology to tissue microarrays (TMAs) or whole tissue sections from large cancer studies has been used to characterize different cell populations in the TME with enhanced reproducibility and accuracy. Generally, mIF data has been used to examine the presence and abundance of …

Comparing Ionoregulation And Modes Of Nitrogen Excretion Across The Life Cycle Of Parasitic And Non-Parasitic Lamprey Species, Shannon Davidson

Theses and Dissertations (Comprehensive)

Abstract

Ionoregulation and nitrogenous waste (N-waste) metabolism in fishes has been extensively documented in teleosts and elasmobranchs, but less so in lampreys (Petromizontiformes). All lamprey species undergo metamorphosis which drastically changes their physiology and modes of feeding. However, differences in ionoregulatory mechanisms due to anadromous versus non anadromous life history strategies emerge following metamorphosis in different lamprey species. Furthermore, some species, such as anadromous juvenile sea lamprey (Petromyzon marinus), are parasitic and migrate to seawater (SW) to ingest blood protein from host fishes, while juveniles of freshwater (FW), non-parasitic species, such as the American brook lamprey …

Understanding The Significance Of Object Recognition In Cowbirds: Exploring The Interplay Of Cognition, Social Behaviour And Reproductive Success, Eric Rushton

Theses and Dissertations (Comprehensive)

Every day, animals use cognitive processes to make decisions in their environment such as those regarding food sources, threats and mates. One such important process provides the ability to recognize objects and individuals in order to guide future actions. Since object recognition and individual recognition are related processes, they may be linked to social cognition and to fitness; links not commonly explored in the literature. In this thesis I seek to examine (1) how brown-headed cowbirds (Molothrus ater) attend to and react to novel objects in their environment and (2) how this ability to recognize objects is related …

Fishes In Murky Waters: Effects Of Total Suspended Solids On Fish Gills And Performance, Xena Montoya

Theses and Dissertations (Comprehensive)

Total suspended solids (TSS) naturally occur in aquatic habitats, but climate change and other anthropogenic disturbances can lead to increased levels. Exposure to high levels of TSS has the potential to damage fish gills through abrasion, leading to impairment of gill function and fish physiology. However, little work has been done exploring the linkages between TSS-induced gill damage and animal performance. Therefore, we tested the hypothesis that TSS damages gill structure, causing gill dysfunction and reducing swimming performance. We exposed salmonids (rainbow trout, brook trout and cutthroat trout) and non-salmonids (fathead minnow and longnose dace) to different TSS concentrations (0-1000 …

Characterizing The Targeting Pathway Of Chloroplast Outer Membrane Protein Oep18 In Arabidopsis Thaliana And Other Targeting Signals Utilized By Outer Envelope Membrane Proteins, Ceaira Hiemstra

Theses and Dissertations (Comprehensive)

Approximately 95% of chloroplast proteins are encoded by nuclear DNA and are post-translationally targeted to the chloroplast. Over half of the 138 known or predicted chloroplast outer membrane (OM) proteins are predicted to utilize four non-canonical targeting pathways. The first two pathways are characterized by containing a single α-helical transmembrane domain (TMD) within the first or last 50 amino acids (AAs), the third pathway is utilized by β-barrels, and the last requires an N-terminal cleavable transit peptide (TP). Recently, a fifth novel pathway called Toc159-like (TOC159L) has been characterized by the presence of a C-terminal reverse TP in Toc159. Subsequent …

Examining Seasonality Of Zooplankton Communities And Water Quality In Yellowknife Area Lakes, Northwest Territories, Nicole Andreola

Theses and Dissertations (Comprehensive)

Frame Lake, located in Yellowknife, Northwest Territories, is one of the city's main attractions. Unfortunately, urbanization and eutrophication have led to a decline in water quality in the lake. Eutrophication has caused a buildup of organic matter in sediments on the bottom of the lake, which can cause a high oxygen demand when processed by aerobic bacteria. Dissolved oxygen levels are high during the summer, but ice shields the lake from gas exchange with the atmosphere, leading to winter anoxia. This oxygen depletion makes it impossible for sensitive aquatic life, such as fish, to survive in the lake over the …

Incorporating Effects-Based Approaches Into Environmental Impact Assessment To Improve Post-Development Monitoring, Carolyn J M Brown

Theses and Dissertations (Comprehensive)

Over the last 50 years, improvements in design of industrial facilities have significantly reduced environmental impacts. But impacts still occur and monitoring programs are the main mechanism to inform when modification/implementation of mitigation is needed. Informed decisions require adequate baseline (pre-development) data to predict impacts based on the development’s design and to understand when the post-development environment has changed. An adaptive monitoring plan provides an effective way to evaluate monitoring results and allow for proactive responses to environmental change before impacts become difficult or challenging to reverse. Unfortunately, baseline data gathered during an environmental impact assessment (EIA) is often inadequate …

Assessing Road Dust Impacts On Macroinvertebrates Community Structure In Canadian Arctic Lakes, Hong Yi Gao

Theses and Dissertations (Comprehensive)

In the Canadian Arctic, unpaved gravel roads are essential for regional accessibility but are also potential sources of road dust runoff. My study investigated the impacts of road dust from the Dempster and Inuvik-Tuktoyaktuk Highways on adjacent freshwater ecosystems, focusing on water quality parameters and macroinvertebrate communities. Using a stratified random sampling design, 18 lakes were studied across two regions (boreal forest and tundra) and three distance categories from the road (0-300 m, 300-600 m, and > 600 m). Contrary to my initial hypotheses, findings revealed no significant differences in water quality or invertebrate communities relative to distance from the road. …

Elucidating Mechanisms Of Enhanced Dsrna-Nanophytoglycogen Innate Immune Responses In Healthy Human Cells, Nicholas Jadaa

Theses and Dissertations (Comprehensive)

Immunostimulatory nucleic acids, such as long double-stranded RNA (ds)RNA, can stimulate innate immune responses in a non-sequence specific manner. These molecules are recognized by pattern-recognition receptors in the cytoplasm, endosome, and on the cell surface. Activation leads to the production of mediators of innate immune pathways, including type I interferon and proinflammatory cytokines. Although these receptors are present in all cells, their role in non-immune cells is often overlooked due to their lower level of responsiveness. Nanocarriers can enhance these nucleic acid-mediated responses, allowing for exploration of innate immune pathways in non-immune cells. Nanoparticles as carriers of nucleic acids can …

Exposing White Supremacist Ideologies: How Awareness Influences Beliefs In Western Bc's White Working Class, Jessa Paddison

Theses and Dissertations (Comprehensive)

Theodore Allen posits that the white working class plays a pivotal role in anti-racist and anti-capitalist movements. The capitalist system, he argues, sustains itself by fostering an identification with whiteness among the white working class, which impedes alliances across racial lines and perpetuates ignorance regarding capitalism's limitations. This qualitative study seeks to explore the potential for disrupting white supremacist ideologies among white working-class individuals through heightened awareness of whiteness. Grounded in Critical Race Theory (CRT) and Critical whiteness Studies (CwS), the research aims to expose these ideologies by fostering critical reflection and anti-racist behaviours. The study employs a comparative approach …

Upcycling Imperfect Broccoli And Carrots Into Healthy Snacks Using An Innovative 3d Food Printing Approach, Safoura Ahmadzadeh, Taylor Clary, Alex Rosales, Ali Ubeyitogullari

Food Science Faculty Publications and Presentations

Vegetables are healthy foods with nutritional benefits; however, nearly one-third of the world's vegetables are lost each year, and some of the losses happen due to the imperfect shape of the vegetables. In this study, imperfect vegetables (i.e., broccoli and carrots) were upcycled into freeze-dried powders to improve their shelf-life before they were formed into food inks for 3D printing. The rheology of the food inks, color analysis of the uncooked and cooked designs, and texture analysis of the cooked designs were determined. The inks with 50% and 75% vegetables provided the best printability and shape fidelity. 3D printing at …

Synthesis And Biophysical Analysis Of Modified Cell-Penetrating Peptides, Joel Mitchell

Theses and Dissertations (Comprehensive)

Cell-penetrating peptides (CPPs) are a family of peptides that have the ability to penetrate biological membranes. They were discovered in the late 1980s and have been the topic of many studies. Much of the interest in CPPs has been due to their ability to translocate biological membranes, and the possibility that they could offer a novel drug delivery method by conjugation to biologically active molecules. Linear CPPs can be modified to form cyclic structures. This change in structure has been observed to enhance the stability and penetrative ability of the CPPs which have been studied. The current thesis focuses on …

Returning To Physical Activity Following Injury: Exploring Psychological Readiness In Middle-Aged Adults, Hunter Martin

Theses and Dissertations (Comprehensive)

Previous researchers have focused on a variety of psychological aspects of injury rehabilitation in the context of returning to competitive sport (Ardern et al., 2016; Donald, 2019; Podlog et al., 2022; Webster et al., 2018). Return to sport decisions have been largely based on physical assessment and functional ability tests with little focus on psychological elements of recovery (Podlog et al., 2015). The existing literature on psychological readiness (PR) to return to sport has grown in recent years, primarily exploring the experiences of young adult athletes aged 18-30 (Podlog et al., 2022). There has been no previous research exploring the …

Genome-Based Pathogenicity Potential Of Salmonella Isolated From Diverse Sources, Jared Mr Crocco

Theses and Dissertations (Comprehensive)

Bacterial human pathogens are among the leading causes of death around the world, especially in low income and developing countries. One important element in a bacterium’s ability to cause disease are genes that directly contribute to pathogenicity called virulence factors. A second significant aspect are antimicrobial resistance genes which allow microorganisms to persist in the presence of antimicrobial agents. In this project I aimed to determine if Salmonella isolated from different sources differed in pathogenicity profiles based on the complement of genes identified through genomic analysis. Accordingly, Salmonella genomes were organized into 8 groups: animal, clinical, human, environmental, food, water …

Tailoring Biometric Innovation To Privacy Law In The Retail Industry, Bailey White

SMU Science and Technology Law Review

Biometric data technology is trending in retail. Retailers utilize biometric data to improve their bottom line through virtual try-on technology (VTOT), contactless payment methods, fingerprint scanners, and more—albeit at potentially steep prices. Many types of biometric technology used in retail fall under strict U.S. state privacy laws, exposing businesses to serious legal and financial consequences. This Comment provides an analysis of the current state of biometric data privacy law in the U.S., focusing on Illinois’ Biometric Information Privacy Act (BIPA), California’s Consumer Privacy Act (CCPA), Privacy Rights Act (CPRA), and more. This Comment also identifies proposed legislation, relevant case law, …

Predictors Of Canadians’ Psychological Well-Being In Retirement: A Mixed Methods Approach, Jessica Miller

Theses and Dissertations (Comprehensive)

In prior decades, retirement research focused on the negative effects of the life transition—such as negative psychological well-being caused by factors such as difficulties adjusting to retirement, feelings of a role loss, or the financial effects of retirement. However, there is considerable agreement across recent research studies that post-retirement years are marked by positive psychological well-being due to a variety of factors. For example, retirees often spend more time in roles (such as volunteer positions) that provide life satisfaction. The present study uses both quantitative and qualitative methods to examine factors related to well-being in retirement among individuals living in …

Effect Of Rare Earth Element Mixtures On Daphnia Magna, Celine Do

Theses and Dissertations (Comprehensive)

Rare earth elements (REEs) are increasingly being used in modern technologies and as such, there is an increasing concern for the potential environmental risk associated with anthropogenic contamination. In addition to there being very little data available for individual REEs, there is also a lack of knowledge concerning mixtures. The objective of my study was to investigate the chronic effects of lanthanum (La) and yttrium (Y) as well as the acute effects of neodymium (Nd), praseodymium (Pr) and Y as a single metal and as a mixture to Daphnia magna. Standard 21-d chronic tests and 48-h single metal acute …

Structural And Functional Analysis Of The Putatively Virulent Gene Products Tde1414, Tde1511, And Tde2714 From The Oral Pathogen Treponema Denticola, Brock W. Corbett

Theses and Dissertations (Comprehensive)

Periodontitis is a destructive polymicrobial disease of the teeth and gums characterized by dental plaque biofilms on the tooth surface, severe inflammation of surrounding gum tissues, and the resorption of alveolar bone. Discussed as one of the most prevalent conditions plaguing humankind, increased clinical parameters of periodontitis is associated with the increased presence of three bacteria known as the “red complex”: Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola. Various transcriptomic and proteomic studies of T. denticola when incorporated into mature biofilms have illuminated key gene targets the bacterium may use as virulence factors to aid in pathogenesis. …

Multiscale Modelling Of Brain Networks And The Analysis Of Dynamic Processes In Neurodegenerative Disorders, Hina Shaheen

Theses and Dissertations (Comprehensive)

The complex nature of the human brain, with its intricate organic structure and multiscale spatio-temporal characteristics ranging from synapses to the entire brain, presents a major obstacle in brain modelling. Capturing this complexity poses a significant challenge for researchers. The complex interplay of coupled multiphysics and biochemical activities within this intricate system shapes the brain's capacity, functioning within a structure-function relationship that necessitates a specific mathematical framework. Advanced mathematical modelling approaches that incorporate the coupling of brain networks and the analysis of dynamic processes are essential for advancing therapeutic strategies aimed at treating neurodegenerative diseases (NDDs), which afflict millions of …