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Articles 61 - 90 of 817973
Full-Text Articles in Entire DC Network
Genetic Drivers Of Progression In Alzheimer’S Disease Are Distinct From Disease Risk, Celeste E. Cohen, Shane Fernandez, Umran Yaman, Ahmad R. Ehyaei, Eleftheria Kodosaki, Aydan Askarova, Tenielle Porter, Eleanor O’Brien, Paul Maruff, Alexi Nott, John A. Hardy, Simon M. Laws, Dervis A. Salih, Maryam Shoai
Genetic Drivers Of Progression In Alzheimer’S Disease Are Distinct From Disease Risk, Celeste E. Cohen, Shane Fernandez, Umran Yaman, Ahmad R. Ehyaei, Eleftheria Kodosaki, Aydan Askarova, Tenielle Porter, Eleanor O’Brien, Paul Maruff, Alexi Nott, John A. Hardy, Simon M. Laws, Dervis A. Salih, Maryam Shoai
Research outputs 2022 to 2026
Background: Recent trials in Alzheimer’s disease (AD) demonstrate encouraging outcomes. These trials target risk mechanisms identified through genetic analysis whilst directly aiming to reduce progression rates. Evidence from other neurodegenerative diseases suggests the genetics of progression is distinct from risk of disease. To expand these initial successes and improve clinical outcomes further we need to understand genetics of progression of disease. These can be deduced through rigorous analysis of meticulously phenotyped longitudinal cohorts. In this study we first looked at known genetic drivers of risk, namely polygenic risk scores for AD and APOE‑ε4, to assess their role in progression. This …
Kinesiology Department Chairs’ Perceptions Of Their Training And Preparation, Kason O’Neil
Kinesiology Department Chairs’ Perceptions Of Their Training And Preparation, Kason O’Neil
Electronic Theses and Dissertations
Department chairs are responsible for leading academic departments in higher education. These individuals regularly make important decisions regarding such things as managing faculty and academic programming, overseeing budgets, and supporting student needs. Despite these responsibilities, many people become department chairs without receiving formal leadership training. This study explored how kinesiology department chairs across the United States viewed their preparation for the role and the importance of leadership training. A total of 111 department chairs completed an online survey about their background, previous training, and the importance of training for different administrative responsibilities. The results showed that most chairs had little …
Methods For Tagging Whale Sharks: Insights Into Performance And Best Practices With A Focus On Clamp Attachments, Freya C. Womersley, Sofia Green, Alberto Garcia-Baciero, Ronan Conlon, Amy L. Jeffries, Matt J. Waller, Sara S. Ratão, Nuno Queiroz, Pedro Afonso, Gonzalo Araujo, Adam Barnett, Christine Barry, Michael L. Berumen, Farukhkha Bloch, Ginevra Boldrocchi, Camrin D. Braun, Ryan Caillouet, Constance Chapman, Jesse E.M. Cochran
Methods For Tagging Whale Sharks: Insights Into Performance And Best Practices With A Focus On Clamp Attachments, Freya C. Womersley, Sofia Green, Alberto Garcia-Baciero, Ronan Conlon, Amy L. Jeffries, Matt J. Waller, Sara S. Ratão, Nuno Queiroz, Pedro Afonso, Gonzalo Araujo, Adam Barnett, Christine Barry, Michael L. Berumen, Farukhkha Bloch, Ginevra Boldrocchi, Camrin D. Braun, Ryan Caillouet, Constance Chapman, Jesse E.M. Cochran
Faculty Publications
Background: Biologging and telemetry have transformed our understanding of marine megafauna movement ecology. Yet, methodological constraints continue to limit data quality and deployment duration. Devices recording whale shark (Rhincodon typus) behaviours and movements have been used for decades, but they remain challenging to deploy and vary in success. Recently, spring-loaded clamp-based systems have emerged as one of the most widely used approaches to attach electronic tags to the fins of this globally endangered species. Currently, however, no consensus guidelines exist as to how to optimise this approach, potentially leading to continued underperforming deployments limiting analysis potential. Here, we synthesise experiences …
Evaluating The Impact Of Research Equipment Availability On Scientific Rigor, Reproducibility, And Innovation Across Stem Disciplines, Lyndi G. Hraban
Evaluating The Impact Of Research Equipment Availability On Scientific Rigor, Reproducibility, And Innovation Across Stem Disciplines, Lyndi G. Hraban
Honors Program: Senior Projects (Public)
Research infrastructure plays a central role in shaping the quality and innovative capacity of scientific research. This study evaluates how the availability of research equipment influences scientific rigor, reproducibility, and innovation across STEM disciplines. Drawing on literature from science-to-science research, policy studies, and discipline-specific analyses, this project synthesizes existing scholarship to explore the relationship between access to infrastructure and key research outcomes. Findings across the literature indicate that access to advanced and well-maintained equipment can strengthen scientific rigor by enabling more precise measurements, improved experimental control, and the implementation of standardized research protocols. Shared and centralized facilities are also associated …
Reduced Mediators Released By Cyanobacteria During Exoelectrogenesis Detected Using Differential Pulse Voltammetry, Laura T. Wey, Monica Brachi, Yagut Allahverdiyeva, Shelley D. Minteer
Reduced Mediators Released By Cyanobacteria During Exoelectrogenesis Detected Using Differential Pulse Voltammetry, Laura T. Wey, Monica Brachi, Yagut Allahverdiyeva, Shelley D. Minteer
Chemistry Faculty Research & Creative Works
Cyanobacteria generate electrical current through exoelectrogenesis (extracellular electron transfer) downstream of photosynthesis, yet the identity of the endogenous redox mediator(s) responsible remains unresolved. Here, we apply differential pulse voltammetry (DPV) to detect and characterise redox-active species released by Synechocystis sp. PCC 6803 under illumination. To enable sensitive detection, we developed an electrolyte intermediate between BG11 (Blue-Green-11) growth medium and MOPS (3-(N-morpholino)propanesulfonic acid) buffer that minimises background electrochemical interference while maintaining short-term cellular functionality. DPV revealed multiple light-enhanced oxidation peaks (0.1–0.65 V vs. saturated calomel electrode (SCE)) that were not resolvable using cyclic voltammetry, providing evidence that cyanobacteria release reduced compounds …
A Global High-Resolution Comprehensive Heat Indices Dataset From 1950 To 2024, Abdul Malik, Sateesh Masabathini, Mohsin Ahmed Shaikh, Qinqin Kong, Muhammad Usman, Dasari Hari Prasad, Ibrahim Hoteit
A Global High-Resolution Comprehensive Heat Indices Dataset From 1950 To 2024, Abdul Malik, Sateesh Masabathini, Mohsin Ahmed Shaikh, Qinqin Kong, Muhammad Usman, Dasari Hari Prasad, Ibrahim Hoteit
All Works
Heatwaves are becoming more intense and frequent as global temperatures rise, affecting vulnerable populations, particularly in low-income communities. Addressing the impacts of heatwaves requires high-resolution data to assess their influence on labour productivity, public health, and climate risk. We introduce the Comprehensive Heat Indices (CHI) dataset, a high-resolution (0.1° × 0.1°) hourly dataset from 1950 to 2024, derived from the ERA5 and ERA5-Land reanalyses. The CHI dataset encompasses thirteen heat stress indices, including wet-bulb temperature, universal thermal climate index, mean radiant temperature, wind chill, and lethal heat stress index (Ls). Thresholds for Ls are empirically linked to mortality, enabling the …
Comparative Performance Of Physiological Vital-Sign Forecasting Under Random And Patient-Wise Splitting Using Deep Learning, Lavanya Vasavi Chittem Reddy
Comparative Performance Of Physiological Vital-Sign Forecasting Under Random And Patient-Wise Splitting Using Deep Learning, Lavanya Vasavi Chittem Reddy
Theses and Dissertations
Physiological vital-sign forecasting estimates future measurements based on recent temporal patterns and can support analysis of continuously recorded monitoring data. This study comparatively evaluated deep feedforward, recurrent, bidirectional recurrent, long short-term memory, and bidirectional long short-term memory architectures for one-step-ahead forecasting of peripheral oxygen saturation, heart rate, and pulse rate. Each model received consecutive observations of peripheral oxygen saturation, heart rate, pulse rate, respiratory rate, and age, while separate single-output models predicted the next value of the selected target.
Random and patient-wise data splitting were compared using identical input definitions, preprocessing procedures, model architectures, and training hyperparameters. The strongest architecture …
Utilizing The Invasive Fruitwood Pyrus Calleryana As Substrate For Mushroom Cultivation, An Experimental Study In Practical Sustainability, Matthew D. Helton
Utilizing The Invasive Fruitwood Pyrus Calleryana As Substrate For Mushroom Cultivation, An Experimental Study In Practical Sustainability, Matthew D. Helton
Masters Theses and Doctoral Dissertations
This study evaluated the feasibility of using woodchips from the invasive Pyrus calleryana (Callery pear) as substrate for mushroom cultivation. Pleurotus ostreatus, Hericium erinaceus, and Ganoderma lucidum were grown on a pear wood substrate and on a conventional oak substrate to compare, yield, sensory attributes, and metabolite production. P. ostreatus showed no significant differences in yield or biological efficiency (p > 0.05), only sweetness (p = 0.022) differed significantly. H. erinaceus yield and efficiency were similar (p > 0.05), with greater second-flush yields in oak controls (p = 0.034) but no sensory differences (p > 0.05). G. lucidum performance was comparable across treatments …
Weathering The Divide: Social Determinants, Neighborhood Context, And Systemic Lupus Erythematosus Among African American Women, Vanessa Cl Morman
Weathering The Divide: Social Determinants, Neighborhood Context, And Systemic Lupus Erythematosus Among African American Women, Vanessa Cl Morman
Electronic Theses and Dissertations
Background: Systemic lupus erythematosus (SLE) disproportionately affects African American women and contributes to racial health disparities in the United States. Although genetic susceptibility influences disease risk, growing evidence suggests that social determinants of health (SDOH), including neighborhood conditions, structural racism, and socioeconomic disadvantage, contribute to disease development and progression. Epigenetic mechanisms may provide a biological pathway linking adverse social conditions to chronic disease disparities. This dissertation examined the influence of SDOH on SLE disparities through evidence synthesis and empirical investigation to inform public health practice and policy.
Methods: This integrated learning experience consisted of three complementary manuscripts. Aim 1 was …
Leveraging Mammal Mycophagy To Determine Environmental Drivers Of Truffle Diversity, Brittany Hartsock
Leveraging Mammal Mycophagy To Determine Environmental Drivers Of Truffle Diversity, Brittany Hartsock
Electronic Theses and Dissertations
Many mycorrhizal fungi are hypogeous (truffle-forming), producing underground fruiting bodies. Studying truffles is inherently challenging due to their hidden nature. However, mycophagous mammals provide a unique opportunity to study hypogeous fungi because they rely on truffles as a food source. Although several truffle species have recently been described in the southern Appalachian region, their fruiting patterns remain poorly understood. To address this, we quantified truffle richness and spore loads from 670 Peromyscus scat samples collected across 42 sites spanning an environmental gradient during 2024 in the Blue Ridge Mountains of East Tennessee. We found that truffle richness and spore abundance …
Exploring Competitive Dynamics Between Pseudomonas Baetica And Salmonella In A Polymicrobial System, Braxton E.M. Stout
Exploring Competitive Dynamics Between Pseudomonas Baetica And Salmonella In A Polymicrobial System, Braxton E.M. Stout
Electronic Theses and Dissertations
The global rise in antimicrobial resistance has catalyzed a greater focus on polymicrobial research aimed at characterizing microbial interactions and uncovering new therapeutic strategies. Though it has long been of interest, environmental soil-derived bacteria remain largely under-represented in research and thus uncharacterized in this field. This project aimed to identify soil microbes that display inhibitory mechanisms to potential nosocomial pathogens. Soil sample S1S3-2 displayed inhibitory phenotypes toward numerous bacteria and was identified as Pseudomonas baetica. In both planktonic and biofilm growth, P. baetica was able to inhibit Salmonella arizonae through a contact-dependent and temperature-dependent manner. Screening of a transposon insertion …
Phytochemical And In-Vitro Cytotoxic Analyses Of Flavonoid Species Isolated From Chromolaena Leivensis, Luke A. Bryant
Phytochemical And In-Vitro Cytotoxic Analyses Of Flavonoid Species Isolated From Chromolaena Leivensis, Luke A. Bryant
Electronic Theses and Dissertations
As a leading cause of death worldwide, cancer and its treatments remain a primary source of interest among researchers. Modern studies are looking into bioselective cytotoxicity to create new chemotherapies that do not have the same harsh side effects as those we use today. Natural product research has a promising future for the development of such treatments. Specifically, polar flavonoids may be the key to a bioselective treatment. Such flavonoid species are native to plants, often within flower petals or within the body. A natural antioxidant, they are designed not to harm healthy cells. This study focuses on the plant …
"Please Put The Phone Down!": Self-Determination Theory Applied To Parental Social Media Mediation, Benjamin A. Dolowich
"Please Put The Phone Down!": Self-Determination Theory Applied To Parental Social Media Mediation, Benjamin A. Dolowich
Dissertations
The majority of adolescents and young adults use social media (Chaddock, 2024; Coyne et al., 2013). Parents are faced with the challenge of considering the role social media may play in their children’s lives (Valkenburg et al., 2013). Using self-determination theory as a framework (Deci & Ryan, 2000), we investigated psychological needs as one mechanism connecting parental social media mediation strategies with well-being and emotional distress in a sample of young adults. Participants were 244 undergraduate students who completed online questionnaires. The results highlighted that controlling styles of parental social media mediation have an association with emotional distress. Psychological needs …
A Critical Review Of Pharmaceutical Pollutants In Soil And Air: Ecotoxicological Impacts On Animal, Plant And Microbial Communities - Health Hazards And Waste Management, Md Faisal Amin, Md. Saydur Rahman
A Critical Review Of Pharmaceutical Pollutants In Soil And Air: Ecotoxicological Impacts On Animal, Plant And Microbial Communities - Health Hazards And Waste Management, Md Faisal Amin, Md. Saydur Rahman
School of Integrative Biological & Chemical Sciences Faculty Publications
Pharmaceutical contamination in soil and air has become a critical environmental concern due to its widespread sources, complex behavior, and long-lasting ecological impacts. This review comprehensively explores the presence, fate, and effects of pharmaceutical compounds in soil, highlighting their entry routes, environmental persistence, and biological consequences. Pharmaceuticals infiltrate terrestrial and aquatic environments through various pathways, including agricultural application, pharmaceutical manufacturing waste, sewage sludge, hospital and household discharges, irrigation with contaminated water, and atmospheric deposition. A wide range of drug classes, such as antibiotics, analgesics, non-steroidal anti-inflammatory drugs, antidepressants, anticancer drugs, and hormones, have been identified in both soil and air …
Wildfire And Fuel Treatments In Utah: A Practical Guide And Outcomes From An Oak-Maple Ecosystem, Annie E. Prescott
Wildfire And Fuel Treatments In Utah: A Practical Guide And Outcomes From An Oak-Maple Ecosystem, Annie E. Prescott
All Graduate Theses and Dissertations, Fall 2023 to Present
Wildfire is a natural part of Utah’s landscapes, but as wildfires become more extreme and communities continue to expand into wildland areas, it is increasingly important to understand how wildfires behave and how their negative effects can be mitigated. One way to reduce wildfire risks and protect life, property, and ecosystem services is through fuel treatments — actions that reduce the amount and arrangement of flammable vegetation through mechanical removal, wildland fire, or other methods.
Information on wildfire behavior and fuel treatments is abundant but often scattered, ecosystem-specific and difficult to access. In addition, most research in the Western U.S. …
The Willing And The Compelled: How Power And Place Shape Human-Bison Coexistence In Poland And The United States, Patrick Orville Kelly
The Willing And The Compelled: How Power And Place Shape Human-Bison Coexistence In Poland And The United States, Patrick Orville Kelly
All Graduate Theses and Dissertations, Fall 2023 to Present
Wildlife recovery programs depend not just on animals, but on how people feel about living with them. The degree to which people accept the disruptions wildlife brings to their lives, known as social tolerance, can determine whether a recovery program succeeds or fails, yet it remains understudied and underapplied in management plans. This dissertation studies how people in Poland and the western United States feel about living with the two living species of bison, the largest land animals in Europe and North America. In Poland, we surveyed 242 residents living at different distances from European bison habitat. Surprisingly, the most …
Balancing Root-Zone Oxygenation And Rhizosphere Stability: The Impact Of Aeration And Hypoxia On Hydroponic Plant Growth, Christian D. Baker
Balancing Root-Zone Oxygenation And Rhizosphere Stability: The Impact Of Aeration And Hypoxia On Hydroponic Plant Growth, Christian D. Baker
All Graduate Theses and Dissertations, Fall 2023 to Present
As the global population and food demand continue to increase, growers must look to innovative and sustainable methods for plant cultivation. Hydroponics is a popular method of sustainable plant cultivation where plant roots are suspended over a liquid nutrient solution. Hydroponics uses less water compared to traditional agriculture because there is no evaporation or solution runoff. It also maximizes land use, requires fewer pesticides and herbicides, and enables year-round cultivation in controlled environments. However, indoor hydroponic systems rely on artificial lighting, which has higher energy costs than traditional farming methods. Optimizing growing conditions is therefore critical to ensure long-term economic …
A Global Image-Based Data Repository Of Killer Whale Interactions With Elasmobranchs, Emma Luck, Isabella L. Reeves, Maeva Terrapon, Rebecca Wellard, Stephanie K. Venables, Alison V. Towner, Alison A. Kock, Charlotte Hussain, Molly Altschwager, Rosie Ballard, Evans Baudin, Nancy Black, Evan Brodsky, Jade Cantrall, Julio Cardoso, Matt I.D. Carter, Oliver Clarke, Santiago Diaz-Pazmino, David Donnelly, Georgina Cabayol Ferraz, Arlaine Francisco, Laura González García, Mark Jackman, Aimee Jan, Eric Martin, Dane Mcdermott, James Moskito, Blair Ranford, Jesús Erick Higuera Rivas, Jasmin O’Brien, Anton Oleynik, Hernán Orellana-Vásquez, Daniela Alarcón Ruales, Gemma Sharp, Jade Sharp, Alisa Schulman-Janiger, Colleen M. Talty, Paul Tixier, John A. Totterdell, Steve Truluck, Jennah Tucker, Tara Weberg, M. Fernanda Urrutia-Osorio, Machi Yoshida, Jochen R. Zaeschmar, Lauren Meyer
A Global Image-Based Data Repository Of Killer Whale Interactions With Elasmobranchs, Emma Luck, Isabella L. Reeves, Maeva Terrapon, Rebecca Wellard, Stephanie K. Venables, Alison V. Towner, Alison A. Kock, Charlotte Hussain, Molly Altschwager, Rosie Ballard, Evans Baudin, Nancy Black, Evan Brodsky, Jade Cantrall, Julio Cardoso, Matt I.D. Carter, Oliver Clarke, Santiago Diaz-Pazmino, David Donnelly, Georgina Cabayol Ferraz, Arlaine Francisco, Laura González García, Mark Jackman, Aimee Jan, Eric Martin, Dane Mcdermott, James Moskito, Blair Ranford, Jesús Erick Higuera Rivas, Jasmin O’Brien, Anton Oleynik, Hernán Orellana-Vásquez, Daniela Alarcón Ruales, Gemma Sharp, Jade Sharp, Alisa Schulman-Janiger, Colleen M. Talty, Paul Tixier, John A. Totterdell, Steve Truluck, Jennah Tucker, Tara Weberg, M. Fernanda Urrutia-Osorio, Machi Yoshida, Jochen R. Zaeschmar, Lauren Meyer
Research outputs 2022 to 2026
Killer whales (Orcinus orca) are cosmopolitan apex predators that interact with numerous species, including sharks, skates, and rays (subclass Elasmobranchii). Interactions between killer whales and elasmobranchs have garnered attention from the scientific community, but the dynamics of these events are poorly understood, as interactions are often challenging to observe. In this study, we collated imagery of interactions between killer whales and elasmobranchs to create the first image-based repository of interspecific interactions between marine predators. A total of 320 photos and videos from 82 unique interactions were collected from 12 countries. A minimum of 18 elasmobranch species across 16 genera were …
Radio Frequency Tagging–Enabled Patient Monitoring: Integrating Mobility Tracking With Early Warning Systems For Enhanced Safety, Ahed Abugabah, Prashant Kumar Shukla, Piyush Kumar Shukla, Abhishek Dwivedi
Radio Frequency Tagging–Enabled Patient Monitoring: Integrating Mobility Tracking With Early Warning Systems For Enhanced Safety, Ahed Abugabah, Prashant Kumar Shukla, Piyush Kumar Shukla, Abhishek Dwivedi
All Works
Ensuring patient safety in healthcare environments requires continuous monitoring systems capable of identifying early warning signs of clinical risk. Traditional surveillance methods often fail to capture meaningful patterns in patient movement, limiting their ability to prevent incidents such as falls, prolonged immobility, or unnoticed health deterioration. Radio Frequency Tagging technology has been increasingly adopted for real-time patient tracking; however, existing systems are generally limited to location detection and lack predictive insights into patient behaviour. To overcome these limitations, this study presents a Radio Frequency Tagging-based patient monitoring framework that integrates mobility tracking with an early warning mechanism to enable proactive …
Mtorc2-Nav1.2 Signaling Drives Early Hyperexcitability In Alzheimer’S Disease Mouse Model, Nolan M Dvorak, Jeffrey L Noebels
Mtorc2-Nav1.2 Signaling Drives Early Hyperexcitability In Alzheimer’S Disease Mouse Model, Nolan M Dvorak, Jeffrey L Noebels
Faculty, Staff and Students Publications
Hyperexcitability is a biomarker of early-stage Alzheimer’s Disease (AD) and hastens cognitive decline later in its course. Mechanistic target of rapamycin (mTOR) signaling contributes to the slope of this trajectory, as evidenced by early increased brain expression and the rescue of hyperexcitability by genetic deletion of mTOR complex 2 (mTORC2); however, a molecular mechanism directly linking mTOR signaling to membrane hyperexcitability in early-stage AD remains elusive. Here, we show that hyperactive mTOR signaling stimulates the voltage-gated Na+ channel 1.2 (Nav1.2), a previously identified downstream phosphorylation target of mTORC2 and a key regulator of membrane electrogenesis. Augmented Nav1.2 channel function induced …
Long-Term Analysis Of Pm2.5 Elemental Composition And Source Contributions In Coastal Urban Environments Of Corpus Christi And Houston In Texas, Sai Deepak Pinakana, Jeremy A. Sarnat, Amit U. Raysoni
Long-Term Analysis Of Pm2.5 Elemental Composition And Source Contributions In Coastal Urban Environments Of Corpus Christi And Houston In Texas, Sai Deepak Pinakana, Jeremy A. Sarnat, Amit U. Raysoni
School of Earth, Environmental, & Marine Sciences Faculty Publications
Long-term assessments of fine particulate matter play a key role in identifying persistent and emerging emission contributors. Coastal urban areas are highly susceptible to transboundary dust and wildfire events in addition to local pollution sources. Multi-decadal assessments in these regions using chemical speciation data could offer insights into major pollutant sources and their trends. This study utilizes nearly two decades of PM2.5 elemental composition data at two major coastal cities in Texas: Houston and Corpus Christi. Fourteen trace elements were analyzed to characterize the seasonal variability and long-term source evolution using a combination of Spearman’s correlation analysis, principal component analysis, …
Evaluating The Transformation Of Land Cover, Land Surface Temperature, And Urban Heat Island In Sylhet Division Through Geospatial Analysis, Md Fazle Rabbi Joy, Md Abdur Rahim, Md Mahfuzar Rahman, Sumiaya Amin Preota
Evaluating The Transformation Of Land Cover, Land Surface Temperature, And Urban Heat Island In Sylhet Division Through Geospatial Analysis, Md Fazle Rabbi Joy, Md Abdur Rahim, Md Mahfuzar Rahman, Sumiaya Amin Preota
School of Earth, Environmental, & Marine Sciences Faculty Publications
Rapid and unplanned urbanization has significantly transformed land use/land cover (LULC), contributing to increased land surface temperature (LST) and the emergence of urban heat islands (UHIs), especially in ecologically fragile regions. This study focuses on the Sylhet Division of Bangladesh, assessing LULC changes, LST dynamics, and UHI expansion from 1994 to 2024 using Landsat satellite imagery, normalized difference vegetation index (NDVI), normalized difference water index (NDWI) indices, and field-based LST validation. Unsupervised classification reveals a 191.75% increase in settlement areas and a 25.65% loss in forest cover. Correspondingly, the highest LST zones (> 30 °C) were absent in 1994 but …
In-Hospital Mortality Patterns And Readmissions In Patients With Chronic Obstructive Pulmonary Disease: An Analysis Of The Role Of Pulmonary Hypertension, Saad Afzal Khan, Trishna Parikh, Adishwar Rao, Akriti Agrawal, Aarohi Parikh, Farah Kazzaz, Sarah Shin, Harry Karmouty-Quintana, Maulin Patel, Kha Dinh, Bela Patel, Bindu Akkanti
In-Hospital Mortality Patterns And Readmissions In Patients With Chronic Obstructive Pulmonary Disease: An Analysis Of The Role Of Pulmonary Hypertension, Saad Afzal Khan, Trishna Parikh, Adishwar Rao, Akriti Agrawal, Aarohi Parikh, Farah Kazzaz, Sarah Shin, Harry Karmouty-Quintana, Maulin Patel, Kha Dinh, Bela Patel, Bindu Akkanti
Faculty, Staff and Student Publications
Chronic obstructive pulmonary disease (COPD) may be complicated by pulmonary hypertension (PH). We aimed to understand the impact of PH on in-hospital mortality and quantify the 30-day readmission rate among patients with COPD. For this cross-sectional study, we used the Nationwide Readmissions Database from 2017-2020 to identify adults ≥18 years with COPD. Patients were stratified according to PH diagnosis. Baseline characteristics between groups were compared using the Pearson chi-square test and two-sample t-test. Predictors of in-hospital mortality were determined using multivariate logistic regression analysis adjusted for demographics and confounders. The 30-day readmission rate and prevalence of PH subgroups by baseline …
Methylated Cfdna May Distinguish Between High- And Intermediate-Risk Uveal Melanoma: A Pilot Study, Mike Wu, Daniël P. De Bruyn, Ruben G. Boers, Aaron B. Beasley, Daan M. Hazelaar, Stavros Makrodimitris, Joachim B. Boers, Jolanda Vaarwater, Ronald O.B. De Keizer, Robert M. Verdijk, Nicole C. Naus, Dion Paridaens, Saskia M. Wilting, Elin S. Gray, Wilfred F.J. Van Ijcken, Joost Gribnau, Annelies De Klein, Erwin Brosens, Emine Kiliç
Methylated Cfdna May Distinguish Between High- And Intermediate-Risk Uveal Melanoma: A Pilot Study, Mike Wu, Daniël P. De Bruyn, Ruben G. Boers, Aaron B. Beasley, Daan M. Hazelaar, Stavros Makrodimitris, Joachim B. Boers, Jolanda Vaarwater, Ronald O.B. De Keizer, Robert M. Verdijk, Nicole C. Naus, Dion Paridaens, Saskia M. Wilting, Elin S. Gray, Wilfred F.J. Van Ijcken, Joost Gribnau, Annelies De Klein, Erwin Brosens, Emine Kiliç
Research outputs 2022 to 2026
Background: Uveal melanoma (UM) is a highly aggressive malignancy with a metastatic risk that depends on the molecular subclass. This subclass can be determined through molecular characterization of tumor-derived tissue. With eye-sparing treatments, tumor tissue is rarely available for molecular testing. We hypothesized that minimal invasive biomarkers such as methylated cell-free DNA (cfDNA) or circulating tumor DNA (ctDNA) can be used for prognosis and monitoring of patients. Methods: Plasma cfDNA was isolated from healthy blood donors (HBDs, N = 19) and UM patients (N = 22). Plasma was collected at baseline (localized disease, N = 13) and during follow-up (metastatic …
Climate Change Impacts On Fish-Related Ecosystem Services: Synthesis, Network Analysis, And Strategic Pathways For Coordinated Adaptation, Ebenezer Afrifa-Yamoah, Awuah-Mensah, Stephen Bradshaw, Ute Mueller
Climate Change Impacts On Fish-Related Ecosystem Services: Synthesis, Network Analysis, And Strategic Pathways For Coordinated Adaptation, Ebenezer Afrifa-Yamoah, Awuah-Mensah, Stephen Bradshaw, Ute Mueller
Research outputs 2022 to 2026
Climate change is rapidly disrupting fish-related ecosystem services that underpin global food security, economic livelihoods, and cultural identity across both marine and freshwater systems. While impacts are increasingly recognised, disciplinary fragmentation has hindered integrated understanding of how climate-driven changes in fish populations affect ecosystem service delivery. This review makes two integrated contributions: a hierarchical synthesis tracing causal pathways from physical climate drivers through biological and ecological responses to socioeconomic outcomes, and a qualitative network analysis that maps the interconnections, implementation readiness, and strategic sequencing of seven major adaptation strategies. Ocean warming, acidification, deoxygenation, and their increasingly frequent co-occurrence as compound …
Design Of Automatic Security System Based Internet Of Things At The Museum, Rahmat Ageng Yuwana, Nuryake Fajaryati, Ferry Jie
Design Of Automatic Security System Based Internet Of Things At The Museum, Rahmat Ageng Yuwana, Nuryake Fajaryati, Ferry Jie
Elinvo (Electronics, Informatics, and Vocational Education)
This research aims to determine the procedures for developing an Internet of Things (IoT)-based Automatic Security System as a security device for museum objects and to test its feasibility based on user feedback in museums. The Design Thinking model used consists of five stages: Empathize (understanding the user’s perspective), Define (gathering information on the encountered problems), Ideate (generating innovative ideas), Prototype (creating a prototype of the obtained ideas, ensuring the functionality of each device feature, and validating the product through expert judgment for feedback and product revision), and Testing (evaluating the system’s feasibility using Usability standards based on ISO/IEC 9241-11, …
Caribou Migration And Non-Local Hunting In Northwest Alaska: A Gis Analysis Of Hunting Activity And Its Relationship With Caribou Migration Corridors, Brittney L. Jiménezszabo
Caribou Migration And Non-Local Hunting In Northwest Alaska: A Gis Analysis Of Hunting Activity And Its Relationship With Caribou Migration Corridors, Brittney L. Jiménezszabo
Geography and the Environment: Graduate Student Capstones
Indigenous Alaskans rely on subsistence hunting for food, with Barren-ground caribou making up approximately 27% of their diet. It is believed by subsistence hunters that non-local hunting is forcing a change in caribou migration behavior. This study examined non-local harvesting records from 2013 – 2025 in the northwest and interior Game Management Units (GMU) and Alaksa’s Western Arctic Caribou Herd (WACH) migration range data to answer the question, is there a spatial relationship between non-local harvests and WACH migration behavior. Mixed methods included spatial autocorrelation and local statistics. Findings led to the rejection of the null hypothesis which will help …
Lithium Titanate-Functionalized Mixed Matrix Polymer Membrane For High-Performance Osmotic Energy Conversion, Rockson Kwesi Tonnah, Yasaman Boroumand, Milad Razbin, Mostafa Vahdani, Amir Razmjou, Mohsen Asadnia
Lithium Titanate-Functionalized Mixed Matrix Polymer Membrane For High-Performance Osmotic Energy Conversion, Rockson Kwesi Tonnah, Yasaman Boroumand, Milad Razbin, Mostafa Vahdani, Amir Razmjou, Mohsen Asadnia
Research outputs 2022 to 2026
Reverse electrodialysis (RED) offers a promising route to harvest osmotic energy from salinity gradients, yet practical implementation is hindered by the lack of scalable, high-performance ion-selective membranes that combine efficient ion transport with mechanical robustness and environmental sustainability. Here, we report a mixed matrix membrane composed of polyethersulfone (PES), polyvinylpyrrolidone (PVP), and lithium titanium oxide (Li₂TiO₃, LTO) that addresses these challenges through biomimetic ion transport channels. The strategic integration of LTO nanoparticles introduces ion-exchange sites and oxygen-rich PES ether linkages to create preferential cation transport pathways that mimic biological ion channels. This mixed matrix design delivers over three-fold cation conduction, …
Development Of A Culture System For Eosinophils Derived From Human Cord Blood Stem Cells, Christian Lachance
Development Of A Culture System For Eosinophils Derived From Human Cord Blood Stem Cells, Christian Lachance
Summer Research Program Abstracts
No abstract provided.
Acceleration Of Coagulation Kinetics For Clot Burst Pressure Assessment, Hanuk Kwon
Acceleration Of Coagulation Kinetics For Clot Burst Pressure Assessment, Hanuk Kwon
Summer Research Program Abstracts
No abstract provided.