Digital Commons Network^™

The Benefits Of Medical Tetrahydrocannabinol On Glaucoma, Hunter Kane

Theses, Dissertations and Capstones

Introduction: This paper explores the potential therapeutic benefits of medical Tetrahydrocannabinol (THC) on glaucoma management, particularly in terms of intraocular pressure (IOP) reduction, ocular blood flow, and symptom management. Glaucoma, characterized by increased IOP and progressive optic nerve damage, is a leading cause of irreversible blindness. Current treatments focus on IOP control but may have inadequate efficacy or intolerable side effects, necessitating alternative approaches such as medical THC.

Methods: The study hypothesis posited that medical THC could significantly reduce IOP, enhance ocular blood flow, and improve symptom management in glaucoma patients. To test this hypothesis, a literature review supplemented by …

Renewing Products Liability With Semen, Anita Bernstein

Faculty Scholarship

No abstract provided.

Effect Of Monoclonal Antibodies Ma-33h1f7 And Ma-8h9d4 On Pai-1 In Cells Activated With Tgfβ, Srikar Modukuri

Biotechnology Theses

This study investigates the impact of monoclonal antibody treatment on plasminogen activator inhibitor-1 (PAI-1) expression and secretion in transforming growth factor beta (TGFβ) activated pleural human mesothelial cells. In this study, we examined total PAI-1 levels in conditioned media from human pleural mesothelial cells under various conditions using immunoblot and enzyme-linked immunosorbent assay techniques (ELISA). Specifically, we targeted PAI-1 with monoclonal antibodies (mAbs) MA-33H1F7 and MA-8H9D4, which bind to unique epitopes on PAI-1. A reduction in PAI-1 levels was observed between control and antibody-treated cells by immunoblot analysis of cell conditioned media. ELISA results also revealed a reduction in total …

Federated Graph Anomaly Detection Via Contrastive Self-Supervised Learning, Xiangjie Kong, Wenyi Zhang, Hui Wang, Mingliang Hou, Xin Chen, Xiaoran Yan, Sajal K. Das

Computer Science Faculty Research & Creative Works

Attribute graph anomaly detection aims to identify nodes that significantly deviate from the majority of normal nodes and has received increasing attention due to the ubiquity and complexity of graph-structured data in various real-world scenarios. However, current mainstream anomaly detection methods are primarily designed for centralized settings, which may pose privacy leakage risks in certain sensitive situations. Although federated graph learning offers a promising solution by enabling collaborative model training in distributed systems while preserving data privacy, a practical challenge arises as each client typically possesses a limited amount of graph data. Consequently, naively applying federated graph learning directly to …

Adipose Injectable Filler With Use Of Meshed Dermal Matrix And Porcine Urinary Bladder Matrix For The Management Of A Complex Achilles Wound, Francois M. Lokenye Dpm

Posters

This case highlights a novel approach utilizing a combination of adipose-derived injectable filler, acellular dermal matrix, and porcine urinary bladder matrix to enhance tissue regeneration, provide structural support, and promote wound healing.

Summer Fall 2024, Nova Southeastern University

KPCOM SGA Rounds

No abstract provided.

Lifelines Winter 2024, Southern Adventist University

Lifelines - Biology Department Newsletter

The Spring 2023 issue of Lifelines contains articles on an alumni spotlight, department events, biology and allied health graduates, and Ann Foster.

The Ersatz Of The Plain-Meaning Rule Of Statutory Construction In Sackett V. Epa (Ii), Dana Neacsu

Duquesne Law Review

This essay uses the United States Supreme Court second decision in Sackett v. EPA,¹ or Sackett (II), to stress the obvious: judges are tasked with decoding the nation's laws for everyone's understanding. Or, in the words of John Marshall: "It is emphatically the province and duty of the judicial department to say what the law is."² Later that century, Justice Oliver Wendell Holmes, Jr. further clarified that judicial duty: "Thereupon we ask, not what this man meant, but what those words would mean in the mouth of a normal speaker of English, using them in circumstances …

Hypothyroid: New Insights On An Old Disease, Sara Ward

Graduate Research Projects

No abstract provided.

Cycle Synced Fitness: The Impact Of Menstrual Cycle Phases On Women's Exercise Performance And Health, Sabrina Galindo

Graduate Research Projects

No abstract provided.

Does Intimate Partner Violence Affect A Child's Developing Brain, Betsy Calloway

Graduate Research Projects

No abstract provided.

2024 Campaign Questionnaire, The Ub Bronfein Family Law Clinic, Margaret E. Johnson, Marcy L. Karin

Menstrual Policies and the Bar

No abstract provided.

Digital Clock Drawing As An Alzheimer's Disease Susceptibility Biomarker: Associations With Genetic Risk Score And Apoe In Older Adults, L I Thompson, M Cummings, S Emrani, David J. Libon, A Ang, C Karjadi, R Au, C Liu

Rowan-Virtua School of Osteopathic Medicine Departmental Research

BACKGROUND: Alzheimer's disease (AD) is the leading cause of dementia in older adults, but most people are not diagnosed until significant neuronal loss has likely occurred along with a decline in cognition. Non-invasive and cost-effective digital biomarkers for AD have the potential to improve early detection.

OBJECTIVE: We examined the validity of DCTclockTM (a digitized clock drawing task) as an AD susceptibility biomarker.

DESIGN: We used two primary independent variables, Apolipoprotein E (APOE) ε4 allele carrier status and polygenic risk score (PRS). We examined APOE and PRS associations with DCTclockTM composite scores as dependent measures.

SETTING: We used existing data …

About The Cover

Undergraduate Review

No abstract provided.

The Consequences Of Colonization: A Meaningful Convergence Of Identity, Reality, And Nature In Wide Sargasso Sea, Alyssa Aguiar

Undergraduate Review

Jean Rhys’ Wide Sargasso Sea provides insight into the consequences of colonization through a fractured narrative that details the life of Antoinette Conway, a multicultural white Creole woman. Antoinette is the protagonist of the tale, but rifts in her account become increasingly severe as Antoinette’s sense of self begins to dissolve. As an adolescent, she remains an outcast in the social hierarchy of Jamaica, subsequently growing up surrounded by the effects of colonialism, but belonging to no specific group. This displacement becomes deeply ingrained in Antoinette, worsening as she grows older and loses those closest to her. When Antoinette marries, …

Letter From The Editors, Carly A. Jensen, Emily B. Suter

The Gettysburg Historical Journal

We are proud to present the twenty-third edition of The Gettysburg Historical Journal. The journal embodies the History Department’s dedication to diverse learning and excellence in academics. Each year, the journal publishes the top student work in a range of topics across the spectrum of academic disciplines with different methodological approaches to the study of history. This year, The Gettysburg Historical Journal received a plethora of submissions from both Gettysburg College students and other students around the country. The works accepted this semester focus on the diverse experiences of Americans throughout history, spanning from the American Civil War to the …

Front Matter

The Gettysburg Historical Journal

Front Matter of the Gettysburg Historical Journal 2024

What Explains American Perceptions Of Russia And China?, Shane Stryker

Mahurin Honors College Capstone Experience/Thesis Projects

This undergraduate senior thesis project aims to investigate the question of how Americans perceive the challenges posed by Russia and China comparatively, and which factors have the greatest influence on these perceptions. This is important for many reasons, such as a greater understanding of American public opinion on foreign affairs that may help frame approaches to U.S. foreign policy. Additionally, finding where the American public agrees and disagrees on competitors and challengers provides us with insight that can be used to explain perceptions.

First, there will be a literature review concerning the importance of understanding public opinion, explanations and theories …

I Am Gay And Catholic: An Analysis Of Identity Integration In Lgbtq+ Members Converting To Catholicism, Maria Julian

Mahurin Honors College Capstone Experience/Thesis Projects

This article examines the negotiation of sexual and religious identities among Catholic members of the LGBTQ+ community. I explore context-specific identity negotiation to determine how and why, in a time of “cultural warfare” within the Catholic Church surrounding the acceptance of LGBTQ+ participants, LGBTQ+ members choose to convert to Catholicism. Through semi-structured interviews conducted with members of the LGBTQ+ community, I identify and discuss several themes based on the identity integration process of these individuals: (1) Experiencing “The Call” (the initial interest in Catholicism), (2) Encountering the Religious “Other” (association with a welcoming and enduring Catholic LGBTQ+ Community), (3) Immersion …

Patterns Of Genetic Structure In Spiders Beetles, Naiya Sims

Mahurin Honors College Capstone Experience/Thesis Projects

Spider beetles are a poorly known group of North American beetles in the family Ptinidae. Protection of biodiversity requires knowledge of species- and population-level distinctiveness, so data regarding genetic structure of spider beetles can shed light on conservation priorities. Spider beetles in the genus, Coleotestudus, are distributed broadly in the southwestern US. Given their small size and lack of flight, it is presumed that the dispersal capability of Coleotestudus is limited, leading to strong population structure on a small spatial scale. We used a three-enzyme restriction-site-associated DNA sequencing (3RAD) strategy to identify single nucleotide polymorphisms (SNPs) throughout the genome …

Analysis Of Protein-Protein Interactions Between Legionella Pneumophilia Effectors, Briana Harness

Mahurin Honors College Capstone Experience/Thesis Projects

Legionella pneumophila an intracellular, opportunistic pathogen that is the causative agent of Legionnaires’ disease and Pontiac fever. A key component of Legionella’s pathogenicity is a series of effector proteins, which aid in the establishment of the Legionella-containing vacuole (LCV). The abundant library of effector proteins L. pneumophila has within its arsenal gives L. pneumophila the ability to infect several different hosts. The pathogenesis of L. pneumophila within various hosts depends on its ability to modulate the activity of its effector proteins through protein-protein interactions within effectors and eukaryotic host cell proteins. By understanding how L. pneumophila regulates its effectors, a …

Inquiry: The Unversity Of Arkansas Undergraduate Research Journal - Volume 23 Issue 1 - Spring 2024, Inquiry Editors

Inquiry: The University of Arkansas Undergraduate Research Journal

No abstract provided.

Editor's Note, Thallapuranam Krishnaswamy Suresh Kumar

Inquiry: The University of Arkansas Undergraduate Research Journal

No abstract provided.

Inquiry: The Unversity Of Arkansas Undergraduate Research Journal - Volume 23 Issue 2 - Fall 2024, Inquiry Editors

Inquiry: The University of Arkansas Undergraduate Research Journal

No abstract provided.

Deciphering The Double-Edged Action Of Sting Pathway In Cancer, Neelabh Datta

Inquiry: The University of Arkansas Undergraduate Research Journal

Cancer cells have unstable chromosomes and damaged DNA, which can activate the cellular alarm system cGAS-STING. This mechanism detects DNA in the incorrect location (the cytosol) and produces type I interferons, which can recruit immune cells to combat cancer. However, certain tumours can bypass or use this mechanism for their own benefit. This short article examines how cGAS-STING influences the different cells of the tumour microenvironment (TME), and how it can have both anti-tumour and pro-tumour effects. It also demonstrates how additional STING signals can cause inflammation and contribute to cancer growth. To employ cGAS-STING against cancer, it is critical …

Office Of Nationally Competitive Awards, Inquiry Editors

Inquiry: The University of Arkansas Undergraduate Research Journal

No abstract provided.

Digital Genome And Self-Regulating Distributed Software Applications With Associative Memory And Event-Driven History, Rao Mikkilineni, W. Patrick Kelly, Gideon Crawley

Barowsky School of Business | Faculty Scholarship

Biological systems have a unique ability inherited through their genome. It allows them to build, operate, and manage a society of cells with complex organizational structures, where autonomous components execute specific tasks and collaborate in groups to fulfill systemic goals with shared knowledge. The system receives information from various senses, makes sense of what is being observed, and acts using its experience while the observations are still in progress. We use the General Theory of Information (GTI) to implement a digital genome, specifying the operational processes that design, deploy, operate, and manage a cloud-agnostic distributed application that is independent of …

Machine Intelligence With Associative Memory And Event-Driven Transaction History, Rao Mikkilineni, W. Patrick Kelly

Barowsky School of Business | Faculty Scholarship

Digital machine intelligence has evolved from its inception in the form of computation of numbers to AI, which is centered around performing cognitive tasks that humans can perform, such as predictive reasoning or complex calculations. The state of the art includes tasks that are easily described by a list of formal, mathematical rules or a sequence of event-driven actions such as modeling, simulation, business workflows, interaction with devices, etc., and also tasks that are easy to do “intuitively”, but are hard to describe formally or as a sequence of event-driven actions such as recognizing spoken words or faces. While these …

The Nondual Realization Of Advaita Vedanta Does Not Support A Psychological Theory Of Consciousness, Glenn Hartelius

International Journal of Transpersonal Studies

Advaita Vedanta is seen as something of an authoritative source for nondual philosophies and theories of consciousness that postulate a pure featureless awareness at the base of mental experience. These approaches deviate from both the lineage-based teachings of Advaita Vedanta and the necessary standards of science, constructing compromises that fall short of traditional fidelity and psychological rigor. Dialogues between psychology and Advaita Vedanta need to delineate clearly between a sensate phenomenology of experience and spiritual interpretations that may be implicit within experiential descriptions.

Smokable "Vine Of The Dead": Two Case Studies Of Experiencers Of Both Changa And Near-Death Experiences, Pascal Michael, David Luke, Oliver Robinson

International Journal of Transpersonal Studies

Introduction: Virtually no studies have looked at psychopharmacological combinations as models of the near-death experience (NDE), which is inadequate given the evidently complex neurochemistry occurring near- or at death. An example of such a combination is "changa," a smoked mixture of the psychedelic N,N-DMT and monoamine oxidase inhibitor (MAOI)-containing plants, and as such has been referred to as "smokable ayahuasca" (vine of the dead). Only very few studies, yet not systematically, have included experiencers of both NDEs and psychoactive substances. Methods: Two case studies are presented of individuals who have experienced both a near-death experience and a changa experience, making …