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Executive Committee - Agenda 3/5/2024, Academic Senate

Academic Senate Agendas

No abstract provided.

Experience Of Parents Caring For A Chid With An Acquired Disability, Brad Phillips

Dissertations

Parents caring for a child with an acquired disability often report a negative impact on physical, psychological, emotional, and spiritual health associated with caregiver burden related to their child's complex health needs. This is further complicated by additional challenges related to the loss of a previously healthy child. Traditional patterns of loss follow linear, time-bound stages that have been observed to be unrelated to the experiences of these specific parents and their families. Therefore, the concept transforming loss has been developed to better understand how these parents navigate loss and find meaning in spite of their suffering.

The purpose of …

Potential Protein Signatures For Recurrence Prediction Of Ischemic Stroke, Chengyi Zhang, Yang Liu, Huimin Zhu, Xinying Huang, Cang Guo, Si Cheng, Meng Yuan, Yong Jiang, Xia Meng, S Claiborne Johnston, Yongjun Wang, Wei-Na Jin, Fu-Dong Shi

Faculty, Staff and Student Publications

Background: Acute ischemic stroke is a major cause of mortality and disability worldwide, with approximately 7.4% to 7.7% recurrence within the first 3 months. This study aimed to identify potential biomarkers for predicting stroke recurrence.

Methods and results: We conducted a nested case-control study using a hospital-based cohort from the Third China National Stroke Registry selecting 214 age- and sex-matched patients with ischemic stroke with hypertension and no history of diabetes or heart disease. Using data-independent acquisition for discovery and multiple reaction monitoring for quantitative validation, we identified 26 differentially expressed proteins in large-artery atherosclerosis (Causative Classification of Ischemic Stroke …

Unraveling The Intraday Variations In The Tear Fluid Proteome, Garrett Jones, Jeremy Altman, Saleh Ahmed, Tae Jin Lee, Wenbo Zhi, Shruti Sharma, Ashok Sharma

Faculty, Staff and Student Publications

PURPOSE: Tear fluid is a complex and dynamic biological fluid that plays essential roles in maintaining ocular homeostasis and protecting against the external environment. Owing to the small sample volume, studying the tear proteome is challenging. However, advances in high-resolution mass spectrometry have expanded tear proteome profiling, revealing >500 unique proteins. Tears are emerging as a noninvasive source of biomarkers for both ocular and systemic diseases; nevertheless, intraday variability of proteins in tear fluid remains questionable. This study investigates intraday variations in the tear fluid proteome to identify stable proteins that could act as candidate biomarkers.

METHODS: Tear samples from …

Sex Differences In Revascularization, Treatment Goals, And Outcomes Of Patients With Chronic Coronary Disease: Insights From The Ischemia Trial, Harmony R Reynolds, Derek D Cyr, C Noel Bairey Merz, Leslee J Shaw, Bernard R Chaitman, William E Boden, Karen P Alexander, Yves D Rosenberg, Sripal Bangalore, Gregg W Stone, Claes Held, John Spertus, Kaatje Goetschalckx, Olga Bockeria, Jonathan D Newman, Jeffrey S Berger, Ahmed Elghamaz, Renato D Lopes, James K Min, Daniel S Berman, Michael H Picard, Raymond Y Kwong, Robert A Harrington, Boban Thomas, Sean M O'Brien, David J Maron, Judith S Hochman, Ischemia Research Group

Faculty, Staff and Student Publications

BACKGROUND: Women with chronic coronary disease are generally older than men and have more comorbidities but less atherosclerosis. We explored sex differences in revascularization, guideline-directed medical therapy, and outcomes among patients with chronic coronary disease with ischemia on stress testing, with and without invasive management.

METHODS AND RESULTS: The ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) trial randomized patients with moderate or severe ischemia to invasive management with angiography, revascularization, and guideline-directed medical therapy, or initial conservative management with guideline-directed medical therapy alone. We evaluated the primary outcome (cardiovascular death, myocardial infarction, or hospitalization for …

Performance Classification For Lasso Weights With Penalized Logistic Regression For High-Dimensional Data, Afiaa Raheem Khudhair, Saja Mohammad Hussein

Journal of Economics and Administrative Sciences

In high-dimensional data, classification performance is a crucial consideration. One method of interest is the penalized binary logistic regression. However, the Least Absolute Shrinkage and Selection Operator) The Lasso method may face problems when the appropriate penalty for each coefficient is not determined. For this reason, different weights are used in weighted Lasso estimates to address this issue and improve classification performance. To overcome this limitation, we employ various Weighted Lasso Estimates, each with unique weight assignments, and compare their performance with our fifth proposed weight configuration. This application of Lasso weighting schemes aims to uncover the most effective approach …

Eef1a2 Promotes Pten-Gsk3Β-Scf Complex-Dependent Degradation Of Aurora Kinase A And Is Inactivated In Breast Cancer, Warapen Treekitkarnmongkol, Luisa M Solis, Deivendran Sankaran, Mihai Gagea, Pankaj K Singh, Ragini Mistry, Tristian Nguyen, Kazuharu Kai, Jiajun Liu, Kaori Sasai, Yoshimi Jitsumori, Jianwen Liu, Norio Nagao, Fabio Stossi, Michael A Mancini, Ignacio I Wistuba, Alastair M Thompson, Jonathan M Lee, Juan Cadiñanos, Kwong-Kwok Wong, Catherine M Abbott, Aysegul A Sahin, Suyu Liu, Hiroshi Katayama, Subrata Sen

Faculty, Staff and Student Publications

The translation elongation factor eEF1A promotes protein synthesis. Its methylation by METTL13 increases its activity, supporting tumor growth. However, in some cancers, a high abundance of eEF1A isoforms is associated with a good prognosis. Here, we found that eEF1A2 exhibited oncogenic or tumor-suppressor functions depending on its interaction with METTL13 or the phosphatase PTEN, respectively. METTL13 and PTEN competed for interaction with eEF1A2 in the same structural domain. PTEN-bound eEF1A2 promoted the ubiquitination and degradation of the mitosis-promoting Aurora kinase A in the S and G2 phases of the cell cycle. eEF1A2 bridged the interactions between the SKP1-CUL1-FBXW7 (SCF) ubiquitin …

High Clinical Exome Sequencing Diagnostic Rates And Novel Phenotypic Expansions For Nonisolated Microphthalmia, Anophthalmia, And Coloboma, Bhavana Kunisetty, Bailey A Martin-Giacalone, Xiaonan Zhao, Pamela N Luna, Brian P Brooks, Robert B Hufnagel, Chad A Shaw, Jill A Rosenfeld, A J Agopian, Philip J Lupo, Daryl A Scott

Faculty, Staff and Student Publications

PURPOSE: A molecular diagnosis is only made in a subset of individuals with nonisolated microphthalmia, anophthalmia, and coloboma (MAC). This may be due to underutilization of clinical (whole) exome sequencing (cES) and an incomplete understanding of the genes that cause MAC. The purpose of this study is to determine the efficacy of cES in cases of nonisolated MAC and to identify new MAC phenotypic expansions.

METHODS: We determined the efficacy of cES in 189 individuals with nonisolated MAC. We then used cES data, a validated machine learning algorithm, and previously published expression data, case reports, and animal models to determine …

Hippo Cooperates With P53 To Maintain Foregut Homeostasis And Suppress The Malignant Transformation Of Foregut Basal Progenitor Cells, Yu Jiang, Haidi Huang, Jiangying Liu, Dan Luo, Rongzi Mu, Jianghong Yuan, Jihong Lin, Qiyue Chen, Wufan Tao, Ling Yang, Man Zhang, Pingping Zhang, Fengqin Fang, Jianming Xu, Qingqiu Gong, Zhiping Xie, Yongchun Zhang

Faculty, Staff and Students Publications

Basal progenitor cells serve as a stem cell pool to maintain the homeostasis of the epithelium of the foregut, including the esophagus and the forestomach. Aberrant genetic regulation in these cells can lead to carcinogenesis, such as squamous cell carcinoma (SCC). However, the underlying molecular mechanisms regulating the function of basal progenitor cells remain largely unknown. Here, we use mouse models to reveal that Hippo signaling is required for maintaining the homeostasis of the foregut epithelium and cooperates with p53 to repress the initiation of foregut SCC. Deletion of

Proteomic Associations Of Adverse Outcomes In Human Heart Failure, Marie-Joe Dib, Ahmed Diab, Ali Javaheri, Douglas L Mann, Et Al.

2020-Current year OA Pubs

BACKGROUND: Identifying novel molecular drivers of disease progression in heart failure (HF) is a high-priority goal that may provide new therapeutic targets to improve patient outcomes. The authors investigated the relationship between plasma proteins and adverse outcomes in HF and their putative causal role using Mendelian randomization.

METHODS AND RESULTS: The authors measured 4776 plasma proteins among 1964 participants with HF with a reduced left ventricular ejection fraction enrolled in PHFS (Penn Heart Failure Study). Assessed were the observational relationship between plasma proteins and (1) all-cause death or (2) death or HF-related hospital admission (DHFA). The authors replicated nominally significant …

Dual Membrane-Spanning Anti-Sigma Factors Regulate Vesiculation In Bacteroides Thetaiotaomicron, Evan J Pardue, Mariana G Sartorio, Biswanath Jana, Nichollas E Scott, Wandy L Beatty, Juan C Ortiz-Marquez, Tim Van Opijnen, Fong-Fu Hsu, Robert F Potter, Mario F Feldman

2020-Current year OA Pubs

Bacteroidota are abundant members of the human gut microbiota that shape the enteric landscape by modulating host immunity and degrading dietary- and host-derived glycans. These processes are mediated in part by

Program Review Report 3-5-24, Angela Brock

Program Review Committee

No abstract provided.

Kidney Function Trajectories And Right Heart Failure Following Lvad Implantation, Carl P Walther, Andrew B Civitello, Harveen K Lamba, Nandan K Mondal, Sankar D Navaneethan

Faculty, Staff and Students Publications

BACKGROUND: Preoperative kidney dysfunction is a risk factor for right heart failure (RHF) after implantation of a left ventricular assist device (LVAD). However, characteristic kidney function trajectories before and after post-LVAD RHF are uncertain, so we investigated this.

METHODS AND RESULTS: We identified individuals who received primary continuous-flow LVAD implantation from July 1, 2014 to December 31, 2017 in the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) data set. Incident RHF was ascertained using the INTERMACS definition at 1 and 3 months and classified as transient or persistent. Kidney function trajectories before and after RHF onset, and relationships of …

Ucc Minutes 3-5-24, Angela Brock

UCC Agendas/Minutes

No abstract provided.

Insisting On Success As Resistance: Building An Ecosystem Of Black Joy, Laughter And Affirmation, Whitney Hanley, Breanya Hogue

Black Educology Mixtape "Journal"

School climate is a complex system involving norms, goals, values, relationships, practices and organizational structures. It includes the composition of the school and school practices. School composition encompasses the social and economic characteristics of a school, whereas school practice includes administrative leadership and the utilization of resources (Anyon et al., 2016; Opdenakker & Van Damme, 2006; Rumberger & Palardy, 2005; Thapa et al., 2013). If students do not feel their needs are being met by their school environment their emotional, psychological and academic needs are at risk (Cohen et al., 2009; Connell & Welborn, 1991; Libbey, 2004). Black students in …

Quebec's Weird Frontier: Monts Groulx, An Entire Earth, Will Kemeza

Appalachia

No abstract provided.

News And Notes

Appalachia

No abstract provided.

Detecting The Diatom Hab Genus Pseudo-Nitzschia In The Public Shellfish Harvesting Area Of Huntington Beach State Park Using A Nanopore Sequencing Approach, Megan Cevasco, Aramis Lawson, Zachary Padgett, Elena Renshaw

Journal of South Carolina Water Resources

Harmful algal blooms (HABs) cause detrimental economic, ecological, and human health impacts. A major group of HAB taxa of particular interest in coastal shellfish harvesting grounds consists of domoic-acid producing species within the cosmopolitan marine diatom genus Pseudo-nitzschia. Domoic acid (DA) is a neurotoxic amino acid that bioaccumulates in the tissue of filter-feeding shellfish and is responsible for amnesiac shellfish poisoning (ASP) in humans and other marine life. To minimize human health risks and economically damaging shellfish harvesting closures, there is a need to develop proactive monitoring efforts that focus on determining the environmental conditions likely to support Pseudo-nitzschia HABs. …

Spatial And Temporal Variability In Water Quality And Phytoplankton Community Composition In Charleston Harbor, Abigail Stephens, Nicole Schanke, Emmaline Sheahan, Giacomo Ditullio

Journal of South Carolina Water Resources

The Charleston Harbor estuary is a dynamic ecosystem draining three rivers that surround the rapidly urbanizing greater Charleston area. Projected climate change impacts include elevated sea surface temperature and local changes in water quality that will likely alter biogeochemical cycling as well as phytoplankton abundance and community composition. Partnering with the local non-profit organization Charleston Waterkeeper, surface water samples were collected from late April through October 2021 at 20 sites in the Charleston Harbor estuary system. Water quality parameters measured included sea surface temperature (SST), salinity, pH, dissolved inorganic carbon, chromophoric dissolved organic matter (CDOM), phytoplankton pigments and nitrate and …

Use Of An Autonomous Surface Vehicle To Collect High Spatial Resolution Water Quality Data At Lake Wateree, Sc, Archana Venkatachari, Annie Bourbonnais, Ibrahim Salman, Ioannis Rekleitis, Alberto Quattrini Li, Kathryn L. Cottingham, Holly A. Ewing, Denise Bruesewitz, Emily Arsenault, Quin Shingai

Journal of South Carolina Water Resources

Freshwater resources including lakes and reservoirs are increasingly threatened by harmful cyanobacterial blooms (HCBs). The scarcity of high spatial and temporal resolution data presents challenges for monitoring, predicting, and managing these blooms. Autonomous surface vehicles (ASVs) equipped with water quality sensors represent a powerful tool to obtain high-resolution spatial data at Lake Wateree (LW), South Carolina (SC). LW is a hydroelectric reservoir commonly covered with extensive blooms of the benthic cyanobacteria Microseira (Lyngbya) wollei and Phormium sp., with the thickest mats in shallow coves.

The main objective of this study was to determine the best speed and duration of loiter …

Impacts Of Harmful Algal Blooms (Habs) On Agriculture: A Short Communication, Debabrata Sahoo, Ibrahim Busari, Heather Nix, Sarah A. White

Journal of South Carolina Water Resources

agriculture, which requires clean water, healthy soil, and adequate nutrients, is crucial to meet the growing demand for food and fiber. Over application of nutrients to meet demand has degraded surface water quality, leading to accelerated eutrophication. Cultural eutrophication is a process by which aquatic ecosystems such as ponds, lakes, and estuaries become so enriched with nutrients—primarily nitrogen and phosphorus—as to become unusable for safe consumption and ecological purposes. Eutrophication has intensified due to climate change. Increased temperatures, intense storms, and drought can drive the formation of eutrophic and hypereutrophic conditions. Hypereutrophication results in the rapid proliferation of algae and …

Utilizing Watershed-Based Planning As A Tool To Protect Source Water: A Case Study From The Lower Caw Caw Swamp, Kathryn Ellis, Eric Odom, Gregory Carbone

Journal of South Carolina Water Resources

A watershed-based plan (WBP) is an example of a management tool that addresses nonpoint sources of pollution that affect surface water quality. We apply a simple spreadsheet tool to the Lower Caw Caw Swamp watershed in Orangeburg, South Carolina, to quantify the impact of modest management practices on water quality, and to examine how climate and land-use change could affect water quality in future decades. Three separate climate and land use scenarios are used to measure annual pollutant loads in the basin. Our analysis shows that E. coli loads in current conditions are largely attributed to anthropogenic sources of bacteria …

South Carolina Beach Water Quality: Stakeholder Workshop Identifies Challenges, Needs, And Recommendations, Angelos K. Hannides, Nicole Elko

Journal of South Carolina Water Resources

Coastal water quality is often identified by diverse stakeholders as a major management challenge but can be difficult to define. South Carolina Beach Advocates (SCBA), a nonprofit organization formed in 2015 to educate the public, governmental authorities, and elected officials as to the environmental, economic, and societal impact of South Carolina's beaches and inlets, recognized this challenge and organized a virtual workshop in June 2022 to explore our beachfront communities' water quality management challenges, and discuss various perspectives on beach water quality. Thirty-eight participants from government agencies, local government, industry, academia, and civic society discussed this important topic and identified …

Alteration Of The Interferon Alpha Signaling Pathway Significantly Affects Alzheimer's Disease Pathology In App/Ps1 Mouse Model., Ranjit Kumar Das, Nirakar Sahoo, Chun Xu, Hansapani Rodrigo, Michael Paul Murphy, Upal Roy, Deepa Roy

Research Symposium

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive impairment, memory loss, and disturbances in behavior. The exact cause of the disease is unknown but there is evidence of molecular pathways alteration within the brain. Many molecular mechanisms have been studied for the progression of AD. Nonetheless, the contribution of the signal transducer and activator of transcription 1 (STAT1) and interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) genes have not been well established in AD pathology. This study aimed to investigate the contribution of STAT1 and IFIT3 in the BALB/C and APP/PS1 mouse models. We analyzed the STAT1 …

Symposium: Gender, Health, And The Constitution: Reforming Clinical Trial Pregnancy Exclusions, Jennifer D. Oliva

ConLawNOW

This essay argues the exclusion of pregnant people from drug and biologic clinical trials is paternalistic, unjust, and counterproductive because the failure to include pregnant people in experimental trials can enhance risks to maternal and fetal health. Bioethicists, legal scholars, and other researchers have pleaded for reform in this context for decades. This article describes pregnancy medical drug use and the genesis and evolution of federal regulations and policies that operate to exclude pregnant people from clinical trials. It argues that the implementation of legal reforms that ensure the inclusion of pregnant people in clinical trials is imperative given Covid, …

A Potential Role Of Urinary P75ecd As A Biomarker For Amyotrophic Lateral Sclerosis In An American Cohort, Swati Dhasmana, Anupam Dhasmana, Sheema Khan, Acharan S. Narula, Murali Yallapu, Subhash Chauhan

Research Symposium

Background: Neurological disorders present a unique complexity compared to other diseases, involving multiple risk factors, causes, treatments, and outcomes. These disorders often exhibit various molecular and morphological changes indicative of disruptions in cellular plasticity and resilience. The pathogenesis of many neurological disorders remains unclear, necessitating ongoing investigations. Amyotrophic lateral sclerosis (ALS) exemplifies an idiopathic and fatal neurodegenerative disease marked by the degeneration of upper and lower motor neurons. The average life expectancy post-diagnosis is a mere 36 months, primarily attributed to respiratory muscle denervation.The persistent challenges in ALS clinical trials and the absence of effective therapeutic options have intensified interest …

Role Of Gut Microbiome In Rheumatoid Arthritis, Varsha Gupta, Jaya Prakash

Research Symposium

Background: Every individual is born with some dosha that determines its ‘Prakriti’. In the Ayurvedic text, ‘Aamvata’ is a joint disorder causing polyarticular pain and swelling like that in RA, which is texted to be the result of imbalances of gut doshas. It says that accumulation of Ama or undigested food is the cause, as they release endotoxins/ other proteins. The father of modern medicine, Hippocrates, says that the “gut is the site of all the diseases”. Traditional medicine also emphasises a balanced fibrous diet, nutrition, digestion, good sleep, yoga, and meditation, which holistically affect the body, mind and soul. …

Introduction Of Vegetative And Reproductive Characters Into Trifolium Repens By Interspecific Hybridisation, A H. Marshall, T P.T Michaelson-Yeates, M Meredith, D H. Hides

IGC Proceedings (1977-2023)

Interspecific hybridization between white clover (Trifolium repens L.) and ball clover (T.nigrescens) and Caucasian clover (T.ambiguum) is a means of improving the reproductive growth and persistency of T.repens. F1 hybrids between T.repens and T.nigrescens were produced without ovule culture and confirmed as true hybrids by chromosome counts, isoenzyme analysis and leaf markers. Their growth habit was generally intermediate between the two parents. After backcrossing to T.repens the BC1 and BC2 hybrids had more of the characteristics associated with T.repens though they retained some of the greater reproductive growth of …

Colchicine-Doubling Of Germinating Seedlings Of Interspecific Wildrye Hybrids, T A. Jones, D C. Nielson, H Jaussi

IGC Proceedings (1977-2023)

Colchicine has usually been applied to sterile clones of interspecific grass hybrids to restore fertility. However, when hybrids are partially fertile, colchicine can be applied to germinating seedlings. Four populations of Basin wildrye (Leymus cinereus) X beardless wildrye (L. triticoides) were treated with a 0.2% colchicine solution to double chromosome number from 4x=28 to 8x=56. Doubling percentage was 28, 33, 42, and 44% of all root-tips examined for the four populations. When plants without doubled sectors were discarded, doubling percentage increased to 56, 68, 78, and 78%. Plants with doubled sectors have been placed in crossing blocks …

Ada News - 03/04/2024, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.