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Articles 79381 - 79410 of 818740
Full-Text Articles in Entire DC Network
Self-Esteem Among Adults With Adhd Symptoms, Dana Richelieu
Self-Esteem Among Adults With Adhd Symptoms, Dana Richelieu
Walden Dissertations and Doctoral Studies
This study assessed if attention deficit hyperactivity disorder (ADHD) treatment, ADHD symptoms, social support, gender, coping, and educational attainment predicted self-esteem among adults. It differed from previous research on this topic because it included participants with ADHD symptoms compared to those with formal ADHD diagnoses. Grounded in Leary and Baumeister’s sociometer theory, the study involved using a nonexperimental correlational survey research design to assess this issue. A sample of 272 adult participants living in the United States were recruited. A multiple regression analysis revealed ADHD symptoms, social support, and coping were statistically significant predictors of self-esteem, while ADHD treatment, gender, …
Wmu Board Of Trustees Formal Session ,March 14, 2024, Wmu Board Of Trustees
Wmu Board Of Trustees Formal Session ,March 14, 2024, Wmu Board Of Trustees
WMU Board of Trustees Meetings
Acceptance of the Agenda
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Updates by the Western Student Association President
Capital Intern Program Presentation: Cultivating a Leader: WMU Student's Journey in the
Capital Intern Program
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In-Person, Hybrid, Or Remote: Exploring The Effectiveness Of Teacher Practices On Student Performance During The Covid-19 Pandemic, Ashley M. Segalla
In-Person, Hybrid, Or Remote: Exploring The Effectiveness Of Teacher Practices On Student Performance During The Covid-19 Pandemic, Ashley M. Segalla
LSU Doctoral Dissertations
Schools and universities had to make unexpected changes beginning in Spring 2020 because of the COVID-19 pandemic. In Spring 2021, one university in the southern region of the United States implemented hybrid teaching formats in College Algebra courses, where students attended half of the classes in-person, and the remaining half of classes were attended synchronously and remotely. The purpose of this mixed methods study was to determine if students’ attendance methods (virtual or in-person) impacted their academic performance in the course. Additionally, the study sought to determine how students and the instructor felt student performance was impacted by hybrid attendance. …
The Current - Volume 34 Issue 10, Nova Southeastern University
The Current - Volume 34 Issue 10, Nova Southeastern University
Student Newspapers
No abstract provided.
Rehabilitation Counselor Interventions On Parental-Disability Acceptance, James Samuel Rothrock
Rehabilitation Counselor Interventions On Parental-Disability Acceptance, James Samuel Rothrock
Walden Dissertations and Doctoral Studies
Rehabilitation counselors work with families to assist in transitioning adolescents with intellectual disabilities (ID) from school to adult services. Currently, there is no evidence base for rehabilitation counselors to conceptualize and promote disability acceptance in parents. The purpose of this research was to identify interventions used by rehabilitation counselors with parents at various levels of disability acceptance. The research questions focused on what experiences rehabilitation counselors have had coordinating services with parents of adolescents with ID experiencing various degrees of acceptance and how do they understand and intervene with parental acceptance? The theoretical foundations girding the formation and interpretation of …
The History Of -Eer In English: Suffix Competition Or Symbiosis?, Zachary Dukic, Chris C. Palmer
The History Of -Eer In English: Suffix Competition Or Symbiosis?, Zachary Dukic, Chris C. Palmer
Faculty Articles
Ecological models of competition have provided great explanatory power regarding synonymy in derivational morphology. Competition models of this type have certainly shown their utility, as they have demonstrated, among other things, the relevance of frequency measures, productivity, compositionality and analyzability when comparing the development of morphological constructions. There has been less consideration of alternative models that could be used to describe the historical co-development of suffixes that produce words with sometimes similar forms or meanings but are not inevitably or solely in competition. The symbiotic model proposed in this article may help answer larger questions in linguistics, such as how …
Effect Of Neutralizing Monoclonal Antibody Treatment On Early Trajectories Of Virologic And Immunologic Biomarkers In Patients Hospitalized With Covid-19, Tomas O Jensen, Greg A Grandits, Mamta K Jain, Thomas A Murray, Birgit Grund, Kathryn Shaw-Saliba, Michael A Matthay, Mahsa Abassi, Magdalena Ardelt, Jason V Baker, Peter Chen, Robin L Dewar, Anna L Goodman, Timothy J Hatlen, Helene C Highbarger, Mark Holodniy, Perrine Lallemand, Sylvain Laverdure, Bradley G Leshnower, David Looney, Charalampos D Moschopoulos, Henry Mugerwa, Daniel D Murray, Eleftherios Mylonakis, Stephanie Nagy-Agren, M Tauseef Rehman, Adam Rupert, Randy A Stevens, Stuart Turville, Amy Weintrob, Katherine Wick, Jens Lundgren, Emily R Ko, Activ-3/Tico Study Group
Effect Of Neutralizing Monoclonal Antibody Treatment On Early Trajectories Of Virologic And Immunologic Biomarkers In Patients Hospitalized With Covid-19, Tomas O Jensen, Greg A Grandits, Mamta K Jain, Thomas A Murray, Birgit Grund, Kathryn Shaw-Saliba, Michael A Matthay, Mahsa Abassi, Magdalena Ardelt, Jason V Baker, Peter Chen, Robin L Dewar, Anna L Goodman, Timothy J Hatlen, Helene C Highbarger, Mark Holodniy, Perrine Lallemand, Sylvain Laverdure, Bradley G Leshnower, David Looney, Charalampos D Moschopoulos, Henry Mugerwa, Daniel D Murray, Eleftherios Mylonakis, Stephanie Nagy-Agren, M Tauseef Rehman, Adam Rupert, Randy A Stevens, Stuart Turville, Amy Weintrob, Katherine Wick, Jens Lundgren, Emily R Ko, Activ-3/Tico Study Group
Faculty, Staff and Student Publications
BACKGROUND: Neutralizing monoclonal antibodies (nmAbs) failed to show clear benefit for hospitalized patients with coronavirus disease 2019 (COVID-19). Dynamics of virologic and immunologic biomarkers remain poorly understood.
METHODS: Participants enrolled in the Therapeutics for Inpatients with COVID-19 trials were randomized to nmAb versus placebo. Longitudinal differences between treatment and placebo groups in levels of plasma nucleocapsid antigen (N-Ag), anti-nucleocapsid antibody, C-reactive protein, interleukin-6, and D-dimer at enrollment, day 1, 3, and 5 were estimated using linear mixed models. A 7-point pulmonary ordinal scale assessed at day 5 was compared using proportional odds models.
RESULTS: Analysis included 2149 participants enrolled between …
Visual Thinking Strategies (Vts) In The Clinic: How The Humanities Affect The Way We Make Visual Diagnoses Within Medicine, Mitchell Smith
Visual Thinking Strategies (Vts) In The Clinic: How The Humanities Affect The Way We Make Visual Diagnoses Within Medicine, Mitchell Smith
Undergraduate Honors Theses
Visual Thinking Strategies (VTS), a system of humanistic critical analysis that was developed in the 1990’s by Abigail Housen and Philip Yenawine, affords viewers of art the opportunity to have an increased level of interaction with artwork through the use of questions posed by an instructor. For viewers, such a process of critical analysis affords greater visual literacy. The same is arguably true of medical personnel who have trained to use said process in the making of medical observations and diagnoses. The purpose of this study is to understand if VTS has direct application within the realm of medicine, and …
Is A Dyadic Stressor Experienced As Equally Distressing By Both Partners? The Case Of Perceived Fertility Problems, Julia Mcquillan, Arthur L. Greil, Anna Rybińska, Stacy Tiemeyer, Karina M. Shreffler, Colleen Warner Colaner
Is A Dyadic Stressor Experienced As Equally Distressing By Both Partners? The Case Of Perceived Fertility Problems, Julia Mcquillan, Arthur L. Greil, Anna Rybińska, Stacy Tiemeyer, Karina M. Shreffler, Colleen Warner Colaner
Department of Sociology: Faculty Publications
Using data from a population survey, this article explores whether perceptions of having a fertility problem among 926 U.S. couples in heterosexual relationships (women aged 25–45 and male partners) are associated with distress. Most couples did not perceive a fertility problem (58%). In almost a third (30%) of the couples, only women perceived a fertility problem; in 4%, only the men; and in nearly a fifth (19%), both perceived a problem. Adjusted for characteristics associated with fertility problems and depressive symptoms, those who perceived a problem exhibited significantly more depressive symptoms than those who did not. Fertility problems are sometimes …
New Hard Tick (Acari: Ixodidae) Reports And Detection Of Rickettsia In Ticks From Sierra Nevada De Santa Marta, Colombia, Ángel Oviedo, Miguel M. Rodríguez, Fernando S. Flores, Lyda R. Castro
New Hard Tick (Acari: Ixodidae) Reports And Detection Of Rickettsia In Ticks From Sierra Nevada De Santa Marta, Colombia, Ángel Oviedo, Miguel M. Rodríguez, Fernando S. Flores, Lyda R. Castro
Harold W. Manter Laboratory of Parasitology: Library Materials
The Sierra Nevada de Santa Marta (SNSM), located in northern Colombia, is considered a geographical island with high levels of biodiversity and endemism. However, little is known about tick species and their associated microorganisms at the SNSM. In this study we sampled host-seeking ticks in areas of the town of Minca within the SNSM. We collected 47 ticks identified as Amblyomma pacae, Amblyomma longirostre, Amblyomma ovale, Amblyomma mixtum, Haemaphysalis juxtakochi, Ixodes sp. cf. Ixodes affinis and Ixodes sp. Of these ticks, we tested for Rickettsia spp. by amplifying the gltA, SCA1, and 16S rRNA genes via PCR. Rickettsia amblyommatis …
Cannabis Use Is Associated With Higher Rates Of Pseudarthrosis Following Tlif: A Multi-Institutional Matched-Cohort Study, Xu Tao, Abhijith V. Matur, Syed Khalid, Geet Shukla, Phillip Vorster, Kelly Childress, Rebecca Garner, Justin Gibson, Daryn Cass, Juan C. Mejia Munne, Kyle Mcgrath, Natalie Ivey, Julia Garcia-Vargas, Andrew Wu, Seth Street, Jay P. Mehta, Louisa Onyewadume, Henry Ofori Duah, Benjamin Motley, Joseph S. Cheng, Owoicho Adogwa
Cannabis Use Is Associated With Higher Rates Of Pseudarthrosis Following Tlif: A Multi-Institutional Matched-Cohort Study, Xu Tao, Abhijith V. Matur, Syed Khalid, Geet Shukla, Phillip Vorster, Kelly Childress, Rebecca Garner, Justin Gibson, Daryn Cass, Juan C. Mejia Munne, Kyle Mcgrath, Natalie Ivey, Julia Garcia-Vargas, Andrew Wu, Seth Street, Jay P. Mehta, Louisa Onyewadume, Henry Ofori Duah, Benjamin Motley, Joseph S. Cheng, Owoicho Adogwa
College of Nursing Faculty Research and Publications
Study Design. This was a retrospective cohort study. Objective. To compare the rates of pseudarthrosis in patients undergoing 1 to 3 level transforaminal lumbar interbody fusion (TLIF) procedures between cannabis users and noncannabis users. Summary of Background Data. Recreational use of cannabis is common, though it remains poorly studied and legally ambiguous in the United States. Patients with back pain may turn to adjunctive use of cannabis to manage their pain. However, the implications of cannabis use on the achievement of bony fusion are not well-characterized. Methods. Patients who underwent 1 to 3 level TLIF for degenerative disc disease or …
Consensus-Based Virtual Leader Tracking Algorithm For Flight Formation Control Of Swarm Uavs, Berat Yıldız, Akif Durdu, Ahmet Kayabaşi
Consensus-Based Virtual Leader Tracking Algorithm For Flight Formation Control Of Swarm Uavs, Berat Yıldız, Akif Durdu, Ahmet Kayabaşi
Turkish Journal of Electrical Engineering and Computer Sciences
Technological developments in industrial areas also impact unmanned aerial vehicles (UAVs). Recent improvements in both software and hardware have significantly increased the use of many UAVs in social and military fields. In particular, the widespread use of these vehicles in social areas such as entertainment, shipping, transportation, and delivery and military areas such as surveillance, tracking, and offensive measures has accelerated the research on swarm systems. This study examined the previous investigations on swarm UAVs and aimed to create a more efficient algorithm. The effectiveness of the proposed algorithm was compared with other leader-based applications. A swarm consisting of 5 …
Atomic Comagnetometer Gyroscopes For Inertial Navigation Systems: A Review, Murat Salim Karabinaoglu, Bekir Çakir, Mustafa Engin Başoğlu
Atomic Comagnetometer Gyroscopes For Inertial Navigation Systems: A Review, Murat Salim Karabinaoglu, Bekir Çakir, Mustafa Engin Başoğlu
Turkish Journal of Electrical Engineering and Computer Sciences
In recent years, developments in quantum sensing, laser, and atomic sensor technologies have also enabled advancement in the field of quantum navigation. Atomic-based gyroscopes have emerged as one of the most critical atomic sensors in this respect. In this review, a brief technology statement of spin exchange relaxation free (SERF) and nuclear magnetic resonance (NMR) type atomic comagnetometer gyroscope (CG) is presented. Related studies in the literature have been gathered, and the fundamental compositions of CGs with technical basics are presented. A comparison of SERF and NMR CGs is provided. A basic simulation of SERF CG was carried out because …
Gene Editing-Based Targeted Integration For Correction Of Wiskott-Aldrich Syndrome, Melissa Pille, John M Avila, So Hyun Park, Cuong Q Le, Haipeng Xue, Filomeen Haerynck, Lavanya Saxena, Ciaran Lee, Elizabeth J Shpall, Gang Bao, Bart Vandekerckhove, Brian R Davis
Gene Editing-Based Targeted Integration For Correction Of Wiskott-Aldrich Syndrome, Melissa Pille, John M Avila, So Hyun Park, Cuong Q Le, Haipeng Xue, Filomeen Haerynck, Lavanya Saxena, Ciaran Lee, Elizabeth J Shpall, Gang Bao, Bart Vandekerckhove, Brian R Davis
The Brown Foundation: Institute of Molecular Medicine
Wiskott-Aldrich syndrome (WAS) is a severe X-linked primary immunodeficiency resulting from a diversity of mutations distributed across all 12 exons of the WAS gene. WAS encodes a hematopoietic-specific and developmentally regulated cytoplasmic protein (WASp). The objective of this study was to develop a gene correction strategy potentially applicable to most WAS patients by employing nuclease-mediated, site-specific integration of a corrective WAS gene sequence into the endogenous WAS chromosomal locus. In this study, we demonstrate the ability to target the integration of WAS2-12-containing constructs into intron 1 of the endogenous WAS gene of primary CD34+ hematopoietic stem and progenitor …
Cancer Patients’ Spiritual Well-Being, Religious Coping, And Comfort In Communicating With Physicians, Cheryl Boettger
Cancer Patients’ Spiritual Well-Being, Religious Coping, And Comfort In Communicating With Physicians, Cheryl Boettger
Walden Dissertations and Doctoral Studies
Terminal cancer patients with unmet spiritual needs are more likely to suffer from depression, anxiety, and an overall decrease in the quality of their physical, mental, and spiritual health. Even though the incidence of cancer continues to increase, with better treatment, patients are surviving longer. There is a known connection between spiritual, and physical well-being, but research has indicated that this connection is sometimes overlooked in certain populations. In this phenomenological qualitative study, the participants’ lived experiences communicating with their physician about spirituality while in treatment for cancer were examined. The biopsychosocial-spiritual model was used to explore the lived experiences …
The Theoretical Epigenetic Relationship Between Complex-Ptsd And Adhd In Holocaust Survivors’ Descendants, Y. Sahara Brodsky
The Theoretical Epigenetic Relationship Between Complex-Ptsd And Adhd In Holocaust Survivors’ Descendants, Y. Sahara Brodsky
USF Tampa Graduate Theses and Dissertations
When comparing ADHD and Complex-PTSD, these two disorders share many overlapping features in both areas of the brain that are affected and the behavioral aspects due to deficits in certain brain regions, such as the prefrontal cortex. It is due to this similarity that I predict that c-PTSD is the precursor to the development of ADHD in later generations. Through epigenetic changes that are consistent with c-PTSD diagnosis, these changes to the brain are then passed down the generational line. When this is combined with trauma transference and generational trauma, it creates a situation where both the behaviors inform how …
Analyzing The Relationship Between Preeclamptic Severity And Placental Methylation, Mackenzie C. Maggio
Analyzing The Relationship Between Preeclamptic Severity And Placental Methylation, Mackenzie C. Maggio
USF Tampa Graduate Theses and Dissertations
Preeclampsia (PE) is a life-threatening hypertensive disorder in pregnancy (HDP) characterized by high blood pressure and proteinuria after 20 weeks of gestation. PE poses significant risks to both maternal and child health. An incomplete etiopathogenesis, diverse disease heterogeneity, and limited intervention and detection strategies further exacerbate and perpetuate PE as a major public health concern. By assessing symptom severity of placental tissues from PE pregnancies and analyzing the DNA methylation differences, this thesis aimed to identify epigenetic variations contributing to disease heterogeneity. Using the publicly available dataset GSE 98224, differentially methylated region (DMR) analysis on placental samples (n=48) revealed increasing …
Under Pressure: The Soft Robotic Clap-And-Fling Of Cuvierina Atlantica, Daniel Mead
Under Pressure: The Soft Robotic Clap-And-Fling Of Cuvierina Atlantica, Daniel Mead
USF Tampa Graduate Theses and Dissertations
Evolution over billions of years has led to unique animals of all types. The tiny sea butterfly is one that remains mostly anonymous because of its size and low place on the food chain, but it is a swimming creature that when examined closely reveals a surprise. Shockingly, it has a swimming motion nearly identical to small insects flying at intermediate Reynolds numbers, referred to as the clap-and-fling. The centimeter long pteropod flapping briskly at 5Hz escapes attention with its size and speed. Modeling the clap-and-fling motion of the sea butterfly at a larger scale allows the benefits and uniqueness …
Nutrient Removal Of Biochar Amended Modified Bioretention Systems Treating Nursery Runoff, Nicholas Richardson
Nutrient Removal Of Biochar Amended Modified Bioretention Systems Treating Nursery Runoff, Nicholas Richardson
USF Tampa Graduate Theses and Dissertations
Excess inputs of nutrients, such as nitrogen and phosphorus, to surface water bodies can lead to the presence of harmful algal blooms (HABs). HABs can damage their surrounding environments and the economies dependent on them. Nutrient pollution can be properly controlled and monitored at point-sources, such as wastewater treatment plants, but is more difficult to control for non-point sources, such as fertilizer runoff. One form of fertilizer runoff that remains overlooked is runoff from plant nurseries. Controlled release fertilizers (CRFs) embedded in plant containers at nurseries can leach excess nutrients into the runoff. For nurseries in Florida, best management practices …
A Novel Spatiotemporal Graph Convolutional Network Framework For Functional Connectivity Biomarkers Identification Of Alzheimer’S Disease, Ying Zhang, Le Xue, Shuoyan Zhang, Jiacheng Yang, Qi Zhang, Min Wang, Luyao Wang, Mingkai Zhang, Jiehui Jiang, Yunxia Li
A Novel Spatiotemporal Graph Convolutional Network Framework For Functional Connectivity Biomarkers Identification Of Alzheimer’S Disease, Ying Zhang, Le Xue, Shuoyan Zhang, Jiacheng Yang, Qi Zhang, Min Wang, Luyao Wang, Mingkai Zhang, Jiehui Jiang, Yunxia Li
Faculty, Staff and Student Publications
BACKGROUND: Functional connectivity (FC) biomarkers play a crucial role in the early diagnosis and mechanistic study of Alzheimer's disease (AD). However, the identification of effective FC biomarkers remains challenging. In this study, we introduce a novel approach, the spatiotemporal graph convolutional network (ST-GCN) combined with the gradient-based class activation mapping (Grad-CAM) model (STGC-GCAM), to effectively identify FC biomarkers for AD.
METHODS: This multi-center cross-racial retrospective study involved 2,272 participants, including 1,105 cognitively normal (CN) subjects, 790 mild cognitive impairment (MCI) individuals, and 377 AD patients. All participants underwent functional magnetic resonance imaging (fMRI) and T1-weighted MRI scans. In this study, …
Effect Of Neutralizing Monoclonal Antibody Treatment On Early Trajectories Of Virologic And Immunologic Biomarkers In Patients Hospitalized With Covid-19, Tomas O Jensen, Greg A Grandits, Mamta K Jain, Thomas A Murray, Birgit Grund, Kathryn Shaw-Saliba, Michael A Matthay, Mahsa Abassi, Magdalena Ardelt, Jason V Baker, Peter Chen, Robin L Dewar, Anna L Goodman, Timothy J Hatlen, Helene C Highbarger, Mark Holodniy, Perrine Lallemand, Sylvain Laverdure, Bradley G Leshnower, David Looney, Charalampos D Moschopoulos, Henry Mugerwa, Daniel D Murray, Eleftherios Mylonakis, Stephanie Nagy-Agren, M Tauseef Rehman, Adam Rupert, Randy A Stevens, Stuart Turville, Amy Weintrob, Katherine Wick, Jens Lundgren, Emily R Ko
Effect Of Neutralizing Monoclonal Antibody Treatment On Early Trajectories Of Virologic And Immunologic Biomarkers In Patients Hospitalized With Covid-19, Tomas O Jensen, Greg A Grandits, Mamta K Jain, Thomas A Murray, Birgit Grund, Kathryn Shaw-Saliba, Michael A Matthay, Mahsa Abassi, Magdalena Ardelt, Jason V Baker, Peter Chen, Robin L Dewar, Anna L Goodman, Timothy J Hatlen, Helene C Highbarger, Mark Holodniy, Perrine Lallemand, Sylvain Laverdure, Bradley G Leshnower, David Looney, Charalampos D Moschopoulos, Henry Mugerwa, Daniel D Murray, Eleftherios Mylonakis, Stephanie Nagy-Agren, M Tauseef Rehman, Adam Rupert, Randy A Stevens, Stuart Turville, Amy Weintrob, Katherine Wick, Jens Lundgren, Emily R Ko
Faculty, Staff and Student Publications
BACKGROUND: Neutralizing monoclonal antibodies (nmAbs) failed to show clear benefit for hospitalized patients with coronavirus disease 2019 (COVID-19). Dynamics of virologic and immunologic biomarkers remain poorly understood.
METHODS: Participants enrolled in the Therapeutics for Inpatients with COVID-19 trials were randomized to nmAb versus placebo. Longitudinal differences between treatment and placebo groups in levels of plasma nucleocapsid antigen (N-Ag), anti-nucleocapsid antibody, C-reactive protein, interleukin-6, and D-dimer at enrollment, day 1, 3, and 5 were estimated using linear mixed models. A 7-point pulmonary ordinal scale assessed at day 5 was compared using proportional odds models.
RESULTS: Analysis included 2149 participants enrolled between …
Btn1a1 Is A Novel Immune Checkpoint Mutually Exclusive To Pd-L1, Young-Seung Kim, Seung-Hoon Lee, Andrew H Park, Chunai Wu, Bong-Ki Hong, Hyunjin Jung, Steven H Lin, Stephen S Yoo
Btn1a1 Is A Novel Immune Checkpoint Mutually Exclusive To Pd-L1, Young-Seung Kim, Seung-Hoon Lee, Andrew H Park, Chunai Wu, Bong-Ki Hong, Hyunjin Jung, Steven H Lin, Stephen S Yoo
Faculty, Staff and Student Publications
BACKGROUND: While Programmed cell death protein 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) blockade is a potent antitumor treatment strategy, it is effective in only limited subsets of patients with cancer, emphasizing the need for the identification of additional immune checkpoints. Butyrophilin 1A1 (BTN1A1) has been reported to exhibit potential immunoregulatory activity, but its ability to function as an immune checkpoint remains to be systematically assessed, and the mechanisms underlying such activity have yet to be characterized.
METHODS: BTN1A1 expression was evaluated in primary tumor tissue samples, and its ability to suppress T-cell activation and T cell-dependent tumor clearance was examined. …
Lifestyle Medicine For The Prevention And Treatment Of Pancreatitis And Pancreatic Cancer, Sruthi Kapliyil Subramanian, Bhaumik Brahmbhatt, Jennifer M Bailey-Lundberg, Nirav C Thosani, Pritesh Mutha
Lifestyle Medicine For The Prevention And Treatment Of Pancreatitis And Pancreatic Cancer, Sruthi Kapliyil Subramanian, Bhaumik Brahmbhatt, Jennifer M Bailey-Lundberg, Nirav C Thosani, Pritesh Mutha
Faculty, Staff and Student Publications
The incidence of pancreatitis and pancreatic cancer is on the upswing in the USA. These conditions often lead to higher healthcare costs due to the complex nature of diagnosis and the need for specialized medical interventions, surgical procedures, and prolonged medical management. The economic ramification encompasses direct healthcare expenses and indirect costs related to productivity losses, disability, and potential long-term care requirements. Increasing evidence underscores the importance of a healthy lifestyle in preventing and managing these conditions. Lifestyle medicine employs evidence-based interventions to promote health through six key pillars: embracing a whole-food, plant-predominant dietary pattern; regular physical activity; ensuring restorative …
Label-Aware Distance Mitigates Temporal And Spatial Variability For Clustering And Visualization Of Single-Cell Gene Expression Data, Shaoheng Liang, Jinzhuang Dou, Ramiz Iqbal, Ken Chen
Label-Aware Distance Mitigates Temporal And Spatial Variability For Clustering And Visualization Of Single-Cell Gene Expression Data, Shaoheng Liang, Jinzhuang Dou, Ramiz Iqbal, Ken Chen
Faculty, Staff and Student Publications
Clustering and visualization are essential parts of single-cell gene expression data analysis. The Euclidean distance used in most distance-based methods is not optimal. The batch effect, i.e., the variability among samples gathered from different times, tissues, and patients, introduces large between-group distance and obscures the true identities of cells. To solve this problem, we introduce Label-Aware Distance (LAD), a metric using temporal/spatial locality of the batch effect to control for such factors. We validate LAD on simulated data as well as apply it to a mouse retina development dataset and a lung dataset. We also found the utility of our …
Outpatient Covid-19 Convalescent Plasma Recipient Antibody Thresholds Correlated To Reduced Hospitalizations Within A Randomized Trial, Han-Sol Park, Anna Yin, Caelan Barranta, John S Lee, Christopher A Caputo, Jaiprasath Sachithanandham, Maggie Li, Steve Yoon, Ioannis Sitaras, Anne Jedlicka, Yolanda Eby, Malathi Ram, Reinaldo E Fernandez, Owen R Baker, Aarthi G Shenoy, Giselle S Mosnaim, Yuriko Fukuta, Bela Patel, Sonya L Heath, Adam C Levine, Barry R Meisenberg, Emily S Spivak, Shweta Anjan, Moises A Huaman, Janis E Blair, Judith S Currier, James H Paxton, Jonathan M Gerber, Joann R Petrini, Patrick B Broderick, William Rausch, Marie Elena Cordisco, Jean Hammel, Benjamin Greenblatt, Valerie C Cluzet, Daniel Cruser, Kevin Oei, Matthew Abinante, Laura L Hammitt, Catherine G Sutcliffe, Donald N Forthal, Martin S Zand, Edward R Cachay, Jay S Raval, Seble G Kassaye, Christi E Marshall, Anusha Yarava, Karen Lane, Nichol A Mcbee, Amy L Gawad, Nicky Karlen, Atika Singh, Daniel E Ford, Douglas A Jabs, Lawrence J Appel, David M Shade, Bryan Lau, Stephan Ehrhardt, Sheriza N Baksh, Janna R Shapiro, Jiangda Ou, Yu Bin Na, Maria D Knoll, Elysse Ornelas-Gatdula, Netzahualcoyotl Arroyo-Curras, Thomas J Gniadek, Patrizio Caturegli, Jinke Wu, Nelson Ndahiro, Michael J Betenbaugh, Alyssa Ziman, Daniel F Hanley, Arturo Casadevall, Shmuel Shoham, Evan M Bloch, Kelly A Gebo, Aaron Ar Tobian, Oliver Laeyendecker, Andrew Pekosz, Sabra L Klein, David J Sullivan
Outpatient Covid-19 Convalescent Plasma Recipient Antibody Thresholds Correlated To Reduced Hospitalizations Within A Randomized Trial, Han-Sol Park, Anna Yin, Caelan Barranta, John S Lee, Christopher A Caputo, Jaiprasath Sachithanandham, Maggie Li, Steve Yoon, Ioannis Sitaras, Anne Jedlicka, Yolanda Eby, Malathi Ram, Reinaldo E Fernandez, Owen R Baker, Aarthi G Shenoy, Giselle S Mosnaim, Yuriko Fukuta, Bela Patel, Sonya L Heath, Adam C Levine, Barry R Meisenberg, Emily S Spivak, Shweta Anjan, Moises A Huaman, Janis E Blair, Judith S Currier, James H Paxton, Jonathan M Gerber, Joann R Petrini, Patrick B Broderick, William Rausch, Marie Elena Cordisco, Jean Hammel, Benjamin Greenblatt, Valerie C Cluzet, Daniel Cruser, Kevin Oei, Matthew Abinante, Laura L Hammitt, Catherine G Sutcliffe, Donald N Forthal, Martin S Zand, Edward R Cachay, Jay S Raval, Seble G Kassaye, Christi E Marshall, Anusha Yarava, Karen Lane, Nichol A Mcbee, Amy L Gawad, Nicky Karlen, Atika Singh, Daniel E Ford, Douglas A Jabs, Lawrence J Appel, David M Shade, Bryan Lau, Stephan Ehrhardt, Sheriza N Baksh, Janna R Shapiro, Jiangda Ou, Yu Bin Na, Maria D Knoll, Elysse Ornelas-Gatdula, Netzahualcoyotl Arroyo-Curras, Thomas J Gniadek, Patrizio Caturegli, Jinke Wu, Nelson Ndahiro, Michael J Betenbaugh, Alyssa Ziman, Daniel F Hanley, Arturo Casadevall, Shmuel Shoham, Evan M Bloch, Kelly A Gebo, Aaron Ar Tobian, Oliver Laeyendecker, Andrew Pekosz, Sabra L Klein, David J Sullivan
Faculty, Staff and Students Publications
BACKGROUND
COVID-19 convalescent plasma (CCP) virus-specific antibody levels that translate into recipient posttransfusion antibody levels sufficient to prevent disease progression are not defined.
METHODS
This secondary analysis correlated donor and recipient antibody levels to hospitalization risk among unvaccinated, seronegative CCP recipients within the outpatient, double-blind, randomized clinical trial that compared CCP to control plasma. The majority of COVID-19 CCP arm hospitalizations (15/17, 88%) occurred in this unvaccinated, seronegative subgroup. A functional cutoff to delineate recipient high versus low posttransfusion antibody levels was established by 2 methods: (i) analyzing virus neutralization–equivalent anti–Spike receptor-binding domain immunoglobulin G (anti-S-RBD IgG) responses in donors …
The Relationship Between Adverse Childhood Experiences And Juvenile Offender Typology, Aliza Beth Lipman
The Relationship Between Adverse Childhood Experiences And Juvenile Offender Typology, Aliza Beth Lipman
Dissertations and Theses
Approximately 1 in 5 girls and in 20 boys in the United States are victims of child sexual assault every year. Child sexual assault can lead to multiple negative short term and long-term impacts affecting general health, mental health, interpersonal relationships, socio-economic status, criminal behavior and more. Prevention research focuses on a thorough understanding of the perpetrators of assault and the context surrounding offenses in order to reduce and prevent assault. Within this research, juvenile offenders are perceived as a single homogenous group whereas adult offenders are consistently specified based on offender and offense characteristics. The exploration of the relationship …
Utility Of Peripheral Protein Biomarkers For The Prediction Of Incident Interstitial Features: A Multicentre Retrospective Cohort Study, Samuel Ash, Tracy J Doyle, Bina Choi, Ruben San Jose Estepar, Victor Castro, Nicholas Enzer, Ravi Kalhan, Gabrielle Liu, Russell Bowler, David O Wilson, Raul San Jose Estepar, Ivan O Rosas, George R Washko
Utility Of Peripheral Protein Biomarkers For The Prediction Of Incident Interstitial Features: A Multicentre Retrospective Cohort Study, Samuel Ash, Tracy J Doyle, Bina Choi, Ruben San Jose Estepar, Victor Castro, Nicholas Enzer, Ravi Kalhan, Gabrielle Liu, Russell Bowler, David O Wilson, Raul San Jose Estepar, Ivan O Rosas, George R Washko
Faculty, Staff and Students Publications
INTRODUCTION/RATIONALE: Protein biomarkers may help enable the prediction of incident interstitial features on chest CT.
METHODS: We identified which protein biomarkers in a cohort of smokers (COPDGene) differed between those with and without objectively measured interstitial features at baseline using a univariate screen (t-test false discovery rate, FDR p
RESULTS: In COPDGene, 1305 biomarkers were available and 20 differed between those with and without interstitial features at baseline. Of these, 11 were associated with feature progression over a mean of 5.5 years of follow-up, and of these 4 were available in PLuSS, (angiopoietin-2, matrix metalloproteinase 7, macrophage inflammatory protein 1 …
Advanced Hyperthermia Treatment: Optimizing Microwave Energy Focus For Breast Cancer Therapy, Burak Acar, Tuba Yilmaz Abdolsaheb, Ali Yapar
Advanced Hyperthermia Treatment: Optimizing Microwave Energy Focus For Breast Cancer Therapy, Burak Acar, Tuba Yilmaz Abdolsaheb, Ali Yapar
Turkish Journal of Electrical Engineering and Computer Sciences
This paper presents a fast antenna phase optimization scheme to enable microwave power focusing for breast cancer hyperthermia. The power focusing is achieved through the maximization of the deposited electric field on the target malignant tumor tissue. To do so, a malignant breast tumor, the surrounding breast medium, and the skin of the breast are modeled as a cylindrical structure composed of eccentric cylinders, and electric field distribution is computed analytically in terms of cylindrical harmonics. This approach minimized the computational cost and simplified the breast medium model. To ensure applicability across various breast types, the dielectric properties (DPs) of …
Deep Learning Approaches For Cancer Prognosis Prediction Using Histopathological, Omics, And Clinical Data, Shuai Jiang
Deep Learning Approaches For Cancer Prognosis Prediction Using Histopathological, Omics, And Clinical Data, Shuai Jiang
Dartmouth College Ph.D Dissertations
Accurate prediction of patient outcomes is crucial for shared clinical decision-making, treatment planning, and patients' psychological adjustment. Histopathological features of cancer, including tumor size, lymph node involvement, and metastasis, are commonly incorporated into survival prediction models, underscoring the prognostic value of whole slide images (WSIs). Concurrently, studies have highlighted the significance of omics data, such as transcriptomics, in providing valuable insights into cancer prognosis.
The emerging deep learning methods have brought new opportunities in biomedical informatics. Despite a growing body of studies on the application of deep learning methods for predicting prognosis using WSIs, the results are varied, primarily due …
Assessing Immediate Emotions In The Theory Of Planned Behavior Can Substantially Contribute To Increases In Pro-Environmental Behavior, Vanessa C. Ho, Anne H. Berman, Jackie Andrade, David J. Kavanagh, Stéphane La Branche, Jon May, Conner S. Philson, Daniel T. Blumstein
Assessing Immediate Emotions In The Theory Of Planned Behavior Can Substantially Contribute To Increases In Pro-Environmental Behavior, Vanessa C. Ho, Anne H. Berman, Jackie Andrade, David J. Kavanagh, Stéphane La Branche, Jon May, Conner S. Philson, Daniel T. Blumstein
School of Psychology
The Theory of Planned Behavior (TPB) is a highly influential and powerful behavior change model that offers promising guidance on promoting urgently needed, pro-environmental action. Recent pro-environmental research has successfully augmented TPB using anticipated emotions—the emotions an individual consciously predicts they will experience in relation to possible outcomes of their decision. However, immediate emotions—the emotions an individual actually experiences during decision-making—have received far less attention. Given that immediate emotions are relevant to pro-environmental decision-making and can address the theoretical and empirical limitations of TPB, we contend that pro-environmental studies should explicitly examine immediate emotions within the TPB framework. This article …